This paper considers the compound Poisson risk model perturbed by Brownian motion with variable premium and dependence between claims amounts and inter-claim times via Spearman copula. It is assumed that the insurance...This paper considers the compound Poisson risk model perturbed by Brownian motion with variable premium and dependence between claims amounts and inter-claim times via Spearman copula. It is assumed that the insurance company’s portfolio is governed by two classes of policyholders. On the one hand, the first class where the amount of claims is high, and on the other hand, the second class where the amount of claims is low, this difference in claim amounts has significant implications for the insurance company’s pricing and risk management strategies. When policyholders are in the first class, they pay an insurance premium of a constant amount c<sub>1</sub> and when they are in the second class, the premium paid is a constant amount c<sub>2</sub> such that c<sub>1 </sub>> c<sub>2</sub>. The nature of claims (low or high) is measured via random thresholds . The study in this work will focus on the determination of the integro-differential equations satisfied by Gerber-Shiu functions and their Laplace transforms in the risk model perturbed by Brownian motion with variable premium and dependence between claims amounts and inter-claim times via Spearman copula. .展开更多
Abstract By improving the extended homogeneous balance method, a general method is suggested to derive a new auto-Bgcklund transformation （BT） for （3-k l）-Dimensional Jimbo-Miwa （JM） equation. The auto-BT obtain...Abstract By improving the extended homogeneous balance method, a general method is suggested to derive a new auto-Bgcklund transformation （BT） for （3-k l）-Dimensional Jimbo-Miwa （JM） equation. The auto-BT obtained by using our method only involves one quadratic homogeneity equation written as a bilinear equation. Based on the auto-BT, two-soliton solution of the （3＋1）-Dimensional JM equation is obtained.展开更多
In this paper, the Auto-B?cklund transformation connected with the homogeneous balance method (HB) and the extended tanh-function method are used to construct new exact solutions for the time-dependent coefficients Ca...In this paper, the Auto-B?cklund transformation connected with the homogeneous balance method (HB) and the extended tanh-function method are used to construct new exact solutions for the time-dependent coefficients Calogero-Degasperis (VCCD) equation. New soliton and periodic solutions of many types are obtained. Furthermore, the soliton propagation is discussed under the effect of the variable coefficients.展开更多
In this paper, a weighted fractional Fourier transform(WFRFT) based cooperative overlay system, aiming to guarantee physical layer(PHY) security, is proposed. The paper elaborates how WFRFT and physical layer properti...In this paper, a weighted fractional Fourier transform(WFRFT) based cooperative overlay system, aiming to guarantee physical layer(PHY) security, is proposed. The paper elaborates how WFRFT and physical layer properties of the wireless medium are collaborated to guarantee the secrecy of wireless transmissions. In the proposed system, WFRFT is first preform on the secret data, such that the transmitted signal is distorted and can only be neutralized by inverse-WFRFT with the same parameter. And then two streams of the transformed sequences that bearing different messages are cooperatively and simultaneously transmitted to two legitimate receivers via a beamforming-liked method, respectively. In general, both the rapid spatial decorrelation property and the inherent security features of WFRFT are leveraged, such that only the eavesdropper's is degraded, and hence, the wireless communication secrecy is reliably guaranteed. Numerical simulations are conducted to evaluate the performance of the proposed system in terms of the average bit error rate and the secrecy capacity.展开更多
Ritonavir sulfate is a protease inhibitor widely used in the treatment of acquired immunodeficiency syndrome. In order to elucidate the inherent stability and sensitivity characteristics of ritonavir sulfate, it was i...Ritonavir sulfate is a protease inhibitor widely used in the treatment of acquired immunodeficiency syndrome. In order to elucidate the inherent stability and sensitivity characteristics of ritonavir sulfate, it was investigated under forced thermal and hydration stress conditions as recommended by the Inter- national Conference on Harmonization guidelines. In addition, competency of vibrational （infrared and Raman） spectroscopy was assessed to identify structural changes of the drug symbolizing its stress degradation. High performance liquid chromatography was used as a confirmatory technique for both thermal and hydration stress study, while thermogravimetric analysis]differential thermal analysis and atomic force microscopy substantiated the implementation of vibrational spectroscopy in this frame- work. The results exhibited high thermal stability of the drug as significant variations were observed in the diffuse reflectance infrared Fourier transform spectra only after the drug exposure to thermal radiations at 100 ℃. Hydration behavior of ritonavir sulfate was evaluated using Raman spectroscopy and the value of critical relative humidity was found to be 〉 67%. An important aspect of this study was to utilize vibrational spectroscopic technique to address stability issues of pharmacological molecules, not only for their processing in pharmaceutical industry, but also for predicting their shelf lives and suitable storage conditions.展开更多
Using the truncated Painleve expansion, symbolic computation, and direct integration technique, we study analytic solutions of （2＋1）-dimensional Boussinesq equation. An auto-Backlund transformation and a number of ...Using the truncated Painleve expansion, symbolic computation, and direct integration technique, we study analytic solutions of （2＋1）-dimensional Boussinesq equation. An auto-Backlund transformation and a number of exact solutions of this equation have been found. The set of solutions include solitary wave solutions, solitoff solutions, and periodic solutions in terms of elliptic Jacobi functions and Weierstrass ＆ function. Some of them are novel.展开更多
This paper considers a cold standby repairable system consisting of twosupplemental equipments and a single repoirman. In the system, the failure distribu-tions and repair distributions of the two-supplemental equipme...This paper considers a cold standby repairable system consisting of twosupplemental equipments and a single repoirman. In the system, the failure distribu-tions and repair distributions of the two-supplemental equipments are assumed to beexponential distributions, but one supplemental equipment after repair will be “asgood as new” and the other one not. Under these assumptions, seme reliability in-dices are derived by using the geometric process and the method of supplementaryvariable.展开更多
In this paper, an in situ metallographic video system was used to study the morphology in Cu-Zn-Al shape memory alloy (SMA) during thermal cycling phase tmnsforma-tion. There are seven different types of martensite mo...In this paper, an in situ metallographic video system was used to study the morphology in Cu-Zn-Al shape memory alloy (SMA) during thermal cycling phase tmnsforma-tion. There are seven different types of martensite morphology in Cu-Zn-Al SMA,i.e. plate, spean bamboo, noose, round-spot, line and dot-like martensites. During transformation and inverse-transformation, the thermoelastic martensites were rising and falling, growing and shrinking, splitting and merping. The growth patterns of thermoelastic martensite were divided into three types: fast growing, very slow ex-pansion and uniform automatic growth. Automatic growth appeared when ageing at a temperature below Ms. The result, for the first time, coofirmed Olson and Cohen,s suggestion that thermoelastic martensite may be automatically grown when ageing be-low Ms. With increasing numbers of thermal cycling, both the memory recovery ratio (% )and memory recoverp degradation (%) degraded logarithmically. The degrada-tion was steep in the initial stage and then became more and more gradual in the middle and the final stages caused by the stabilisation of martensite. In the initial stage, vacancies assumed the controlling role, while dislocations took the major role in other stages. The martensite transformation caused the intedeces to become bent and blurmd, but with increasing cycling numbers, the movements of interface had the same degradation effects as the memory recovery ratio curves. Under these conditions, we also found the martensites on one side of the intedece became reorientated and par-allel to the intedece. It was therefore concluded that the movement degradation of the interface and the appearance of bamboo like martensite induced the degradation of two way shape memory effect (TWMP).展开更多
In this paper, under the Painleve-integrable condition, the auto-Biicklund transformations in different forms for a variable-coefficient Korteweg-de Vries model with physical interests are obtained through various met...In this paper, under the Painleve-integrable condition, the auto-Biicklund transformations in different forms for a variable-coefficient Korteweg-de Vries model with physical interests are obtained through various methods including the Hirota method, truncated Painleve expansion method, extendedvariable-coefficient balancing-act method, and Lax pair. Additionally, the compatibility for the truncated Painleve expansion method and extended variable-coetfficient balancing-act method is testified.展开更多
This paper presents the information set which originates from a fuzzy set on applying the Hanman-Anirban entropy function to represent the uncertainty. Each element of the information set is called the information val...This paper presents the information set which originates from a fuzzy set on applying the Hanman-Anirban entropy function to represent the uncertainty. Each element of the information set is called the information value which is a product of the information source value and its membership function value. The Hanman filter that modifies the information set is derived by using a filtering function. Adaptive Hanman-Anirban entropy is formulated and its properties are given. It paves the way for higher form of information sets called Hanman transforms that evaluate the information source based on the information obtained on it. Based on the information set six features, Effective Gaussian Information source value (EGI), Total Effective Gaussian Information (TEGI), Energy Feature (EF), Sigmoid Feature (SF), Hanman transform (HT) and Hanman Filter (HF) features are derived. The performance of the new features is evaluated on CASIA-IRIS-V3-Lamp database using both Inner Product Classifier (IPC) and Support Vector Machine (SVM). To tackle the problem of partially occluded eyes, majority voting method is applied on the iris strips and this enables better performance than that obtained when only a single iris strip is used.展开更多
OBJECTIVE： Paraquat （PQ） poisoning-induced pul- monary fibrosis causes asphyxiation and death. The therapeutic potential of intravenous Xuebijing ther- apy in PQ poisoning patients and its underlying im- munomodula...OBJECTIVE： Paraquat （PQ） poisoning-induced pul- monary fibrosis causes asphyxiation and death. The therapeutic potential of intravenous Xuebijing ther- apy in PQ poisoning patients and its underlying im- munomodulatory effects on transforming growth factor （TGF）-131 and procollagen type III peptide （PIIIP） were investigated. METHODS： Thirty-six acute PQ poisoning patients were randomly assigned to conventional therapy （Group A） and intravenous Xuebijing administra- tion plus conventional therapy （Group 13）. Twenty volunteers served as controls （Group C）. Blood sam- ples were collected upon admission （day O） and at post-treatment days 5, 10, and 14. TGF-β1 and PIIIP concentrations were determined by ELISA and ana- lyzed for intra- and inter-group differences over time. One-month follow-up was conducted for de- termining the mortality rate. RESULTS： TGF-β1 and PIIIP levels were significantly higher in PQ poisoning patients and increased over time （Groups A and B vs C, P〈0.01）. However, the TGF-β1 and PIIIP levels were consistently significant- ly lower in Group B compared with those of Group A （P〈0.01）. The 1-month mortality rate was also lower in Group B compared with that of Group A （P〈0.05）. PQ poisoning patients showed remark- ably high levels of TGF-β1 and PIIIP, which increased as PQ-induced pulmonary fibrosis progressed. CONCLUSION： Treatment with intravenous Xuebi- jing plus conventional therapy significantly low- ered TGF-β1 and PIIIP levels, which indicates thera- peutic efficacy in the treatment of PQ poisoning pa- tients.展开更多
Model-driven architecture （MDA） has become a main stream technology for software-intensive system design. The main engineering principle behind it is that the inherent complexity of software development can only be ...Model-driven architecture （MDA） has become a main stream technology for software-intensive system design. The main engineering principle behind it is that the inherent complexity of software development can only be mastered by building, analyzing and manipulating system models. MDA also deals with system complexity by provid- ing component-based design techniques, allowing indepen- dent component design, implementation and deployment, and then system integration and reconfiguration based on com- ponent interfaces. The model of a system in any stage is an integration of models of different viewpoints. Therefore, for a model-driven method to be applied effectively, it must pro- vide a body of techniques and an integrated suite of tools for model construction, validation, and transformation. This requires a number of modeling notations for the specifica- tion of different concerns and viewpoints of the system. These notations should have formally defined syntaxes and a unified theory of semantics. The underlying theory of the method is needed to underpin the development of tools and correct use of tools in software development, as well as to formally ver- ify and reason about properties of systems in mission-critical applications. The modeling notations, techniques, and tools must be designed so that they can be used seamlessly in sup- porting development activities and documentation of artifactsin software design processes. This article presents such a method, called the rCOS, focusing on the models of a system at different stages in a software development process, their se- mantic integration, and how they are constructed, analyzed, transformed, validated, and verified.展开更多
OBJECTIVE: To investigate the effect of Banxia Xiexin decoction(BXD) on Helicobacter pylori(Hp)-related peptic ulcers(PUs) and the possible mecha-nism underlying BXD actions via the transforming growth factor-β/small...OBJECTIVE: To investigate the effect of Banxia Xiexin decoction(BXD) on Helicobacter pylori(Hp)-related peptic ulcers(PUs) and the possible mecha-nism underlying BXD actions via the transforming growth factor-β/small mothers against decapentaplegic(TGF-β/Smad) signaling pathway.METHODS: PU patients with cold-heat complex syndrome were randomly assigned to groups that received Chinese or Western medicines with 20 patients in each group. Serum was collected after 7 d of treatment. The healthy group included 20 individuals. Gastric mucosal epithelial cell line GES-1 was cultured in vitro and randomly divided into the following seven groups: control, model, healthy,Western Medicine, prior treatment, low dosage,and high dosage. After 72 h of treatment with the corresponding serum, the m RNA and protein expression levels of TGF-β1, Smad3, and Smad7 were measured by reverse transcription quantitative polymerase chain reaction and western blotting, respectively.RESULTS: The m RNA expression levels of TGF-β1 and Smad3 in GES-1 cells were increased after Hp introduction, and these increased levels were reduced by the BXD-containing serum. The protein levels of p-Smad3, but not TGF-β1 or Smad3, were significantly increased in Hp-treated GES-1 cells,and treatment with the BXD-containing serum markedly decreased the protein levels. Smad7 expression was significantly enhanced following treatment with the BXD-containing serum at transcriptional and protein levels in a dose-dependent manner.CONCLUSION: BXD regulates the TGF-β/Smad signaling pathway by inhibiting the expression of TGF-β1 and Smad3, and increasing the expression of Smad7.展开更多
By virtue of the new technique of performing integration over Dirac＇s ket-bra operators, we ex- plore quantum optical version of classical optical transformations such as optical Fresnel transform, Hankel transform, ...By virtue of the new technique of performing integration over Dirac＇s ket-bra operators, we ex- plore quantum optical version of classical optical transformations such as optical Fresnel transform, Hankel transform, fractional Fourier transform, Wigner transform, wavelet transform and Fresnel- Hadmard combinatorial transform etc. In this way one may gain benefit for developing classical optics theory from the research in quantum optics, or vice-versa. We cannot only find some new quantum mechanical unitary operators which correspond to the known optical transformations, de- riving a new theorem for calculating quantum tomogram of density operators, but also can reveal some new classical optical transformations. For examples, we find the generalized Fresnel opera- tor （GFO） to correspond to the generalized Fresnel transform （GFT） in classical optics. We derive GFO＇s normal product form and its canonical coherent state representation and find that GFO is the loyal representation of symplectic group multiplication rule. We show that GFT is just the transformation matrix element of GFO in the coordinate representation such that two successive GFTs is still a GFT. The ABCD rule of the Gaussian beam propagation is directly demonstrated in the context of quantum optics. Especially, the introduction of quantum mechanical entangled state representations opens up a new area in finding new classical optical transformations. The complex wavelet transform and the condition of mother wavelet are studied in the context of quantum op- tics too. Throughout our discussions, the coherent state, the entangled state representation of the two-mode squeezing operators and the technique of integration within an ordered product （IWOP） of operators are fully used. All these have confirmed Dirac＇s assertion： ＂...for a quantum dynamic system that has a classical analogue, unitary transformation in the quantum theory is the analogue of contact transformation in the classical theory＂.展开更多
The aim of this study was to explore the expression of integrin-β1 in different stages of hepaticfibrosis and intervention of resveratrol as well as the way by which integrin-β1 promoted hepaticfibrosis.Hepaticfibrosis...The aim of this study was to explore the expression of integrin-β1 in different stages of hepaticfibrosis and intervention of resveratrol as well as the way by which integrin-β1 promoted hepaticfibrosis.Hepaticfibrosis models of male Sprague Dawley(SD)rats were created and intragastric administration of resveratrol was given in low(40 mg/kg),middle(120 mg/kg)and high(200 mg/kg)dose groups.The expression of integrin-β1,transforming growth factor-β(TGF-β)and tissue inhibitor of metalloproteinase-1(TIMP-1)in different stages of hepaticfibrosis was detected by using RT-PCR.The expression of hexadecenoic acid(HA)and precollagen III(pc III)was assayed by radioimmunoassay.The expression of integrin-β1,TGF-βand TIMP-1 was determined in each group.Liver function and pathological sections of each group in different stages of hepaticfibrosis was tested to judge the therapeutic efficacy of resveratrol at different doses.The expression of integrin-β1 in normal control group was low and steady and was not increased with the development of hepaticfibrosis,but it was increased in other groups.The expression levels of integrin-β1 in the model control group(0.878±0.03,P<0.01)and low dose group(0.855±0.04,P<0.01)were higher than other groups,but there was no difference between model control group and low dose group(P>0.05).The expression levels of integrin-β1 and TGF-βin middle dose group and high dose group were higher than other groups(P<0.01).The expression levels of integrin-β1 and TGF-βin model control group and low dose group were lower than the normal control group(P<0.01).The expression levels of TIMP-1 in the model control and low dose groups were higher than the other groups(P<0.01).The expression levels of TIMP-1 in the middle dose group and the high dose group were lower than the normal control group(P<0.01).The expression of integrin-β1 existed in all stages of hepaticfibrosis of SD rats,and it was increased with the development of hepaticfibrosis.The expression of TGF-βand TIMP-1 was consistent with that of integrin-β1 in different stages of hepaticfibrosis.Resveratrol could improve the degree of hepaticfibrosis of SD rats and decrease the expression of integrin-β1 markedly at a dose of 120 mg/kg.展开更多
The direction dependence of surface wave speed and the influence of electrically and magnetically short/open circuit are investigated in this paper. First, the elastic, piezoelectric and piezomagnetic coefficients in ...The direction dependence of surface wave speed and the influence of electrically and magnetically short/open circuit are investigated in this paper. First, the elastic, piezoelectric and piezomagnetic coefficients in the considered ordinate system are obtained by Bonde transformation from those in the crystal axis ordinate system. Then, the secular equation of surface wave is derived from the free traction condition on the surface of half space with consideration of short/open circuit case. Some numerical examples are given. The direction dependence of surface wave speed and the influences of short/open circuit are shown graphically and discussed based on the numerical results.展开更多
The aim of this paper is to investigate the clin-ical features and transformation of elderly male patients with normal blood glucose levels at fasting and 2 hours after glucose intake but with hyperglycemia(>11.1 m...The aim of this paper is to investigate the clin-ical features and transformation of elderly male patients with normal blood glucose levels at fasting and 2 hours after glucose intake but with hyperglycemia(>11.1 mmol/L)1 hour after oral glucose tolerance test(OGTT-1h HG).Seven years of follow-up visits were per-formed on 189 elderly male outpatients with OGTT-1h HG and data was recorded on their body mass index(BMI),blood pressure,serum cholesterol and triglyceride test results and on their glucose tolerance changes every 1–2 years after taking OGTT;their possible causes were analysed.Follow-up visits revealed that 19 patients with OGTT-1h HG were diagnosed with diabetes(10.1%),78 patients with impaired glucose tolerance(IGT,41.3%),2 patients transformed to normal glucose tolerance(NGT,1.1%)and the remaining 90 patients(47.6%)remained unchanged.Synchronized comparison with IGT patients showed that the ratio of OGTT-1h HG patients turning to diabetes was lower than that of IGT patients(21.1%,x2513.05,P,0.01),and the ratio of OGTT-1h HG patients transforming to NGT was slightly higher(0.4%,x252.46,P.0.05).The prevalence of complications of hypertension,coronary heart disease,cerebral vascular diseases and dyslipidemia in patients with OGTT-1h HG were higher than those with NGT(P,0.05)and were similar to that of IGT patients.As a special phenotype of OGTT and as part of an abnormal glucose tolerance con-formation,patients with OGTT-1h HG warrant special attention,since about half of them were found to have developed diabetes or IGT,and their risk of suffering from vascular diseases were also increased.展开更多
Tu and Deng proposed a class of bent functions which are of optimal algebraic immunity under the assumption of a combinatorial conjecture.In this paper,the authors compute the dual of the Tu-Deng functions and then sh...Tu and Deng proposed a class of bent functions which are of optimal algebraic immunity under the assumption of a combinatorial conjecture.In this paper,the authors compute the dual of the Tu-Deng functions and then show that they are still of optimal algebraic immunity under the assumption of the same conjecture.For another class of Boolean functions constructed by Tang,et al.which are of optimal algebraic immunity with similar forms to Tu-Deng functions,the authors show that they are not bent functions by using some basic properties of binary complete Kloosterman sums.展开更多
Neural progenitor cells(NPC)are those that are the source of neural cells for cell transplantation and gene therapy.The shortage in quantity and the limited life spans of primary cultured cells limit its widespread us...Neural progenitor cells(NPC)are those that are the source of neural cells for cell transplantation and gene therapy.The shortage in quantity and the limited life spans of primary cultured cells limit its widespread use in basic research.Immortalized NPC,which also possess the capacity of self-renewal and can proliferate infinitely,can produce a large number of NPCs with stable phenotype and genotype.Here we report that an immortalized neural progenitor cell strain,which we named as INPC,was suc-cessfully established by gene-transfer of simian virus 40 large T antigen gene mediated by liposomes.The INPC retained the biological characteristics of its original cells and provided a safe and reliable cell platform for the treat-ment of central nervous system diseases and transgenic cell transplantation.INPC could express low levels of MHC antigens which was down-regulated after differentiation.This indicates that INPC possesses poor immunogenicity.The immortalized cells may show good long-term survival and do not elicit an acute immunological response follow-ing transplantation.展开更多
The parallel computation capabilities of modern graphics processing units （GPUs） have attracted increasing attention from researchers and engineers who have been conducting high computational throughput studies. How...The parallel computation capabilities of modern graphics processing units （GPUs） have attracted increasing attention from researchers and engineers who have been conducting high computational throughput studies. However, current single GPU based engineering solutions are often struggling to fulfill their real-time requirements. Thus, the multi-GPU-based approach has become a popular and cost-effective choice for tackling the demands. In those cases, the computational load balancing over multiple GPU ＂nodes＂ is often the key and bottleneck that affect the quality and performance of the real=time system. The existing load balancing approaches are mainly based on the assumption that all GPU nodes in the same computer framework are of equal computational performance, which is often not the case due to cluster design and other legacy issues. This paper presents a novel dynamic load balancing （DLB） model for rapid data division and allocation on heterogeneous GPU nodes based on an innovative fuzzy neural network （FNN）. In this research, a 5-state parameter feedback mechanism defining the overall cluster and node performance is proposed. The corresponding FNN-based DLB model will be capable of monitoring and predicting individual node performance under different workload scenarios. A real=time adaptive scheduler has been devised to reorganize the data inputs to each node when necessary to maintain their runtime computational performance. The devised model has been implemented on two dimensional （2D） discrete wavelet transform （DWT） applications for evaluation. Experiment results show that this DLB model enables a high computational throughput while ensuring real=time and precision requirements from complex computational tasks.展开更多
文摘This paper considers the compound Poisson risk model perturbed by Brownian motion with variable premium and dependence between claims amounts and inter-claim times via Spearman copula. It is assumed that the insurance company’s portfolio is governed by two classes of policyholders. On the one hand, the first class where the amount of claims is high, and on the other hand, the second class where the amount of claims is low, this difference in claim amounts has significant implications for the insurance company’s pricing and risk management strategies. When policyholders are in the first class, they pay an insurance premium of a constant amount c<sub>1</sub> and when they are in the second class, the premium paid is a constant amount c<sub>2</sub> such that c<sub>1 </sub>> c<sub>2</sub>. The nature of claims (low or high) is measured via random thresholds . The study in this work will focus on the determination of the integro-differential equations satisfied by Gerber-Shiu functions and their Laplace transforms in the risk model perturbed by Brownian motion with variable premium and dependence between claims amounts and inter-claim times via Spearman copula. .
基金Supported by National Natural Science Foundation of China under Grant No.11071209 the Natural Science Foundation of the Higer Education Institutions of Jiangsu Province under Grant No.10KJB110011
文摘Abstract By improving the extended homogeneous balance method, a general method is suggested to derive a new auto-Bgcklund transformation （BT） for （3-k l）-Dimensional Jimbo-Miwa （JM） equation. The auto-BT obtained by using our method only involves one quadratic homogeneity equation written as a bilinear equation. Based on the auto-BT, two-soliton solution of the （3＋1）-Dimensional JM equation is obtained.
文摘In this paper, the Auto-B?cklund transformation connected with the homogeneous balance method (HB) and the extended tanh-function method are used to construct new exact solutions for the time-dependent coefficients Calogero-Degasperis (VCCD) equation. New soliton and periodic solutions of many types are obtained. Furthermore, the soliton propagation is discussed under the effect of the variable coefficients.
基金supported by the National Basic Research Program of China under Grant 2013CB329003the National Natural Science Founda-tion General Program of China under Grant 61171110
文摘In this paper, a weighted fractional Fourier transform(WFRFT) based cooperative overlay system, aiming to guarantee physical layer(PHY) security, is proposed. The paper elaborates how WFRFT and physical layer properties of the wireless medium are collaborated to guarantee the secrecy of wireless transmissions. In the proposed system, WFRFT is first preform on the secret data, such that the transmitted signal is distorted and can only be neutralized by inverse-WFRFT with the same parameter. And then two streams of the transformed sequences that bearing different messages are cooperatively and simultaneously transmitted to two legitimate receivers via a beamforming-liked method, respectively. In general, both the rapid spatial decorrelation property and the inherent security features of WFRFT are leveraged, such that only the eavesdropper's is degraded, and hence, the wireless communication secrecy is reliably guaranteed. Numerical simulations are conducted to evaluate the performance of the proposed system in terms of the average bit error rate and the secrecy capacity.
文摘Ritonavir sulfate is a protease inhibitor widely used in the treatment of acquired immunodeficiency syndrome. In order to elucidate the inherent stability and sensitivity characteristics of ritonavir sulfate, it was investigated under forced thermal and hydration stress conditions as recommended by the Inter- national Conference on Harmonization guidelines. In addition, competency of vibrational （infrared and Raman） spectroscopy was assessed to identify structural changes of the drug symbolizing its stress degradation. High performance liquid chromatography was used as a confirmatory technique for both thermal and hydration stress study, while thermogravimetric analysis]differential thermal analysis and atomic force microscopy substantiated the implementation of vibrational spectroscopy in this frame- work. The results exhibited high thermal stability of the drug as significant variations were observed in the diffuse reflectance infrared Fourier transform spectra only after the drug exposure to thermal radiations at 100 ℃. Hydration behavior of ritonavir sulfate was evaluated using Raman spectroscopy and the value of critical relative humidity was found to be 〉 67%. An important aspect of this study was to utilize vibrational spectroscopic technique to address stability issues of pharmacological molecules, not only for their processing in pharmaceutical industry, but also for predicting their shelf lives and suitable storage conditions.
基金National Natural Science Foundation of China under Grant No.10761005the Natural Science Foundation of Inner Mongolia under Grant No.200607010104
文摘Using the truncated Painleve expansion, symbolic computation, and direct integration technique, we study analytic solutions of （2＋1）-dimensional Boussinesq equation. An auto-Backlund transformation and a number of exact solutions of this equation have been found. The set of solutions include solitary wave solutions, solitoff solutions, and periodic solutions in terms of elliptic Jacobi functions and Weierstrass ＆ function. Some of them are novel.
文摘This paper considers a cold standby repairable system consisting of twosupplemental equipments and a single repoirman. In the system, the failure distribu-tions and repair distributions of the two-supplemental equipments are assumed to beexponential distributions, but one supplemental equipment after repair will be “asgood as new” and the other one not. Under these assumptions, seme reliability in-dices are derived by using the geometric process and the method of supplementaryvariable.
文摘In this paper, an in situ metallographic video system was used to study the morphology in Cu-Zn-Al shape memory alloy (SMA) during thermal cycling phase tmnsforma-tion. There are seven different types of martensite morphology in Cu-Zn-Al SMA,i.e. plate, spean bamboo, noose, round-spot, line and dot-like martensites. During transformation and inverse-transformation, the thermoelastic martensites were rising and falling, growing and shrinking, splitting and merping. The growth patterns of thermoelastic martensite were divided into three types: fast growing, very slow ex-pansion and uniform automatic growth. Automatic growth appeared when ageing at a temperature below Ms. The result, for the first time, coofirmed Olson and Cohen,s suggestion that thermoelastic martensite may be automatically grown when ageing be-low Ms. With increasing numbers of thermal cycling, both the memory recovery ratio (% )and memory recoverp degradation (%) degraded logarithmically. The degrada-tion was steep in the initial stage and then became more and more gradual in the middle and the final stages caused by the stabilisation of martensite. In the initial stage, vacancies assumed the controlling role, while dislocations took the major role in other stages. The martensite transformation caused the intedeces to become bent and blurmd, but with increasing cycling numbers, the movements of interface had the same degradation effects as the memory recovery ratio curves. Under these conditions, we also found the martensites on one side of the intedece became reorientated and par-allel to the intedece. It was therefore concluded that the movement degradation of the interface and the appearance of bamboo like martensite induced the degradation of two way shape memory effect (TWMP).
基金supported by the Key Project of the Ministry of Education under Grant No.106033Specialized Research Fund for the Doctoral Program of Higher Education under Grant No.20060006024+2 种基金Ministry of Education,National Natural Science Foundation of China under Grant Nos.60372095 and 60772023Open Fund of the State Key Laboratory of Software Development Environment under Grant No.SKLSDE-07-001Beijing University of Aeronautics and Astronautics,and National Basic Research Program of China (973 Program) under Grant No.2005CB321901
文摘In this paper, under the Painleve-integrable condition, the auto-Biicklund transformations in different forms for a variable-coefficient Korteweg-de Vries model with physical interests are obtained through various methods including the Hirota method, truncated Painleve expansion method, extendedvariable-coefficient balancing-act method, and Lax pair. Additionally, the compatibility for the truncated Painleve expansion method and extended variable-coetfficient balancing-act method is testified.
文摘This paper presents the information set which originates from a fuzzy set on applying the Hanman-Anirban entropy function to represent the uncertainty. Each element of the information set is called the information value which is a product of the information source value and its membership function value. The Hanman filter that modifies the information set is derived by using a filtering function. Adaptive Hanman-Anirban entropy is formulated and its properties are given. It paves the way for higher form of information sets called Hanman transforms that evaluate the information source based on the information obtained on it. Based on the information set six features, Effective Gaussian Information source value (EGI), Total Effective Gaussian Information (TEGI), Energy Feature (EF), Sigmoid Feature (SF), Hanman transform (HT) and Hanman Filter (HF) features are derived. The performance of the new features is evaluated on CASIA-IRIS-V3-Lamp database using both Inner Product Classifier (IPC) and Support Vector Machine (SVM). To tackle the problem of partially occluded eyes, majority voting method is applied on the iris strips and this enables better performance than that obtained when only a single iris strip is used.
文摘OBJECTIVE： Paraquat （PQ） poisoning-induced pul- monary fibrosis causes asphyxiation and death. The therapeutic potential of intravenous Xuebijing ther- apy in PQ poisoning patients and its underlying im- munomodulatory effects on transforming growth factor （TGF）-131 and procollagen type III peptide （PIIIP） were investigated. METHODS： Thirty-six acute PQ poisoning patients were randomly assigned to conventional therapy （Group A） and intravenous Xuebijing administra- tion plus conventional therapy （Group 13）. Twenty volunteers served as controls （Group C）. Blood sam- ples were collected upon admission （day O） and at post-treatment days 5, 10, and 14. TGF-β1 and PIIIP concentrations were determined by ELISA and ana- lyzed for intra- and inter-group differences over time. One-month follow-up was conducted for de- termining the mortality rate. RESULTS： TGF-β1 and PIIIP levels were significantly higher in PQ poisoning patients and increased over time （Groups A and B vs C, P〈0.01）. However, the TGF-β1 and PIIIP levels were consistently significant- ly lower in Group B compared with those of Group A （P〈0.01）. The 1-month mortality rate was also lower in Group B compared with that of Group A （P〈0.05）. PQ poisoning patients showed remark- ably high levels of TGF-β1 and PIIIP, which increased as PQ-induced pulmonary fibrosis progressed. CONCLUSION： Treatment with intravenous Xuebi- jing plus conventional therapy significantly low- ered TGF-β1 and PIIIP levels, which indicates thera- peutic efficacy in the treatment of PQ poisoning pa- tients.
文摘Model-driven architecture （MDA） has become a main stream technology for software-intensive system design. The main engineering principle behind it is that the inherent complexity of software development can only be mastered by building, analyzing and manipulating system models. MDA also deals with system complexity by provid- ing component-based design techniques, allowing indepen- dent component design, implementation and deployment, and then system integration and reconfiguration based on com- ponent interfaces. The model of a system in any stage is an integration of models of different viewpoints. Therefore, for a model-driven method to be applied effectively, it must pro- vide a body of techniques and an integrated suite of tools for model construction, validation, and transformation. This requires a number of modeling notations for the specifica- tion of different concerns and viewpoints of the system. These notations should have formally defined syntaxes and a unified theory of semantics. The underlying theory of the method is needed to underpin the development of tools and correct use of tools in software development, as well as to formally ver- ify and reason about properties of systems in mission-critical applications. The modeling notations, techniques, and tools must be designed so that they can be used seamlessly in sup- porting development activities and documentation of artifactsin software design processes. This article presents such a method, called the rCOS, focusing on the models of a system at different stages in a software development process, their se- mantic integration, and how they are constructed, analyzed, transformed, validated, and verified.
基金Supported by the National Natural Science Foundation of China(Intervention of Serum with Banxia Xiexin Decoction in Human Gastric Epithelial Cells Co-cultured with Helicobacter pylori in vitro Based on the TGF-β/Smad Signaling Pathway and Epigenetics,No.81403331Research on the Mechanism of Compound Prescription of Chinese Traditional Medicine Regulating the Endocannabinoid System in Non-alcoholic Steatohepatitis,No.81503529+2 种基金Mechanism of Chlorogenic Acid and Geniposide in NASH by Regulating Kupffer Cell Polarization Based on the Gut-liver Axis,No.81673660)the Natural Science Foundation of Fujian Province(Intervention of Serum with Soothing Liver and Invigorating Spleen Recipe in Hep G2.2.15 Cells via the JAK2-STAT3Signaling Pathway,No.2014J01363)the Pilot Project of Science and Technology of Fujian Province(Study of Compound Prescription of Chinese Traditional Medicine for Fibrosis Based on the Endocannabinoid System,No.2016D012)
文摘OBJECTIVE: To investigate the effect of Banxia Xiexin decoction(BXD) on Helicobacter pylori(Hp)-related peptic ulcers(PUs) and the possible mecha-nism underlying BXD actions via the transforming growth factor-β/small mothers against decapentaplegic(TGF-β/Smad) signaling pathway.METHODS: PU patients with cold-heat complex syndrome were randomly assigned to groups that received Chinese or Western medicines with 20 patients in each group. Serum was collected after 7 d of treatment. The healthy group included 20 individuals. Gastric mucosal epithelial cell line GES-1 was cultured in vitro and randomly divided into the following seven groups: control, model, healthy,Western Medicine, prior treatment, low dosage,and high dosage. After 72 h of treatment with the corresponding serum, the m RNA and protein expression levels of TGF-β1, Smad3, and Smad7 were measured by reverse transcription quantitative polymerase chain reaction and western blotting, respectively.RESULTS: The m RNA expression levels of TGF-β1 and Smad3 in GES-1 cells were increased after Hp introduction, and these increased levels were reduced by the BXD-containing serum. The protein levels of p-Smad3, but not TGF-β1 or Smad3, were significantly increased in Hp-treated GES-1 cells,and treatment with the BXD-containing serum markedly decreased the protein levels. Smad7 expression was significantly enhanced following treatment with the BXD-containing serum at transcriptional and protein levels in a dose-dependent manner.CONCLUSION: BXD regulates the TGF-β/Smad signaling pathway by inhibiting the expression of TGF-β1 and Smad3, and increasing the expression of Smad7.
文摘By virtue of the new technique of performing integration over Dirac＇s ket-bra operators, we ex- plore quantum optical version of classical optical transformations such as optical Fresnel transform, Hankel transform, fractional Fourier transform, Wigner transform, wavelet transform and Fresnel- Hadmard combinatorial transform etc. In this way one may gain benefit for developing classical optics theory from the research in quantum optics, or vice-versa. We cannot only find some new quantum mechanical unitary operators which correspond to the known optical transformations, de- riving a new theorem for calculating quantum tomogram of density operators, but also can reveal some new classical optical transformations. For examples, we find the generalized Fresnel opera- tor （GFO） to correspond to the generalized Fresnel transform （GFT） in classical optics. We derive GFO＇s normal product form and its canonical coherent state representation and find that GFO is the loyal representation of symplectic group multiplication rule. We show that GFT is just the transformation matrix element of GFO in the coordinate representation such that two successive GFTs is still a GFT. The ABCD rule of the Gaussian beam propagation is directly demonstrated in the context of quantum optics. Especially, the introduction of quantum mechanical entangled state representations opens up a new area in finding new classical optical transformations. The complex wavelet transform and the condition of mother wavelet are studied in the context of quantum op- tics too. Throughout our discussions, the coherent state, the entangled state representation of the two-mode squeezing operators and the technique of integration within an ordered product （IWOP） of operators are fully used. All these have confirmed Dirac＇s assertion： ＂...for a quantum dynamic system that has a classical analogue, unitary transformation in the quantum theory is the analogue of contact transformation in the classical theory＂.
基金supported by the Natural Science Foundation of Shanghai(No.06ZR14090).
文摘The aim of this study was to explore the expression of integrin-β1 in different stages of hepaticfibrosis and intervention of resveratrol as well as the way by which integrin-β1 promoted hepaticfibrosis.Hepaticfibrosis models of male Sprague Dawley(SD)rats were created and intragastric administration of resveratrol was given in low(40 mg/kg),middle(120 mg/kg)and high(200 mg/kg)dose groups.The expression of integrin-β1,transforming growth factor-β(TGF-β)and tissue inhibitor of metalloproteinase-1(TIMP-1)in different stages of hepaticfibrosis was detected by using RT-PCR.The expression of hexadecenoic acid(HA)and precollagen III(pc III)was assayed by radioimmunoassay.The expression of integrin-β1,TGF-βand TIMP-1 was determined in each group.Liver function and pathological sections of each group in different stages of hepaticfibrosis was tested to judge the therapeutic efficacy of resveratrol at different doses.The expression of integrin-β1 in normal control group was low and steady and was not increased with the development of hepaticfibrosis,but it was increased in other groups.The expression levels of integrin-β1 in the model control group(0.878±0.03,P<0.01)and low dose group(0.855±0.04,P<0.01)were higher than other groups,but there was no difference between model control group and low dose group(P>0.05).The expression levels of integrin-β1 and TGF-βin middle dose group and high dose group were higher than other groups(P<0.01).The expression levels of integrin-β1 and TGF-βin model control group and low dose group were lower than the normal control group(P<0.01).The expression levels of TIMP-1 in the model control and low dose groups were higher than the other groups(P<0.01).The expression levels of TIMP-1 in the middle dose group and the high dose group were lower than the normal control group(P<0.01).The expression of integrin-β1 existed in all stages of hepaticfibrosis of SD rats,and it was increased with the development of hepaticfibrosis.The expression of TGF-βand TIMP-1 was consistent with that of integrin-β1 in different stages of hepaticfibrosis.Resveratrol could improve the degree of hepaticfibrosis of SD rats and decrease the expression of integrin-β1 markedly at a dose of 120 mg/kg.
基金Project supported by the National Natural Science Foundation of China(No.10972029)the Science and Technology Program of Educational Commission of Heilongjiang Province of China(No.12541869)the Program of Young Teachers Scientific Research in Qiqihar University(No.2014K-Z03)
文摘The direction dependence of surface wave speed and the influence of electrically and magnetically short/open circuit are investigated in this paper. First, the elastic, piezoelectric and piezomagnetic coefficients in the considered ordinate system are obtained by Bonde transformation from those in the crystal axis ordinate system. Then, the secular equation of surface wave is derived from the free traction condition on the surface of half space with consideration of short/open circuit case. Some numerical examples are given. The direction dependence of surface wave speed and the influences of short/open circuit are shown graphically and discussed based on the numerical results.
文摘The aim of this paper is to investigate the clin-ical features and transformation of elderly male patients with normal blood glucose levels at fasting and 2 hours after glucose intake but with hyperglycemia(>11.1 mmol/L)1 hour after oral glucose tolerance test(OGTT-1h HG).Seven years of follow-up visits were per-formed on 189 elderly male outpatients with OGTT-1h HG and data was recorded on their body mass index(BMI),blood pressure,serum cholesterol and triglyceride test results and on their glucose tolerance changes every 1–2 years after taking OGTT;their possible causes were analysed.Follow-up visits revealed that 19 patients with OGTT-1h HG were diagnosed with diabetes(10.1%),78 patients with impaired glucose tolerance(IGT,41.3%),2 patients transformed to normal glucose tolerance(NGT,1.1%)and the remaining 90 patients(47.6%)remained unchanged.Synchronized comparison with IGT patients showed that the ratio of OGTT-1h HG patients turning to diabetes was lower than that of IGT patients(21.1%,x2513.05,P,0.01),and the ratio of OGTT-1h HG patients transforming to NGT was slightly higher(0.4%,x252.46,P.0.05).The prevalence of complications of hypertension,coronary heart disease,cerebral vascular diseases and dyslipidemia in patients with OGTT-1h HG were higher than those with NGT(P,0.05)and were similar to that of IGT patients.As a special phenotype of OGTT and as part of an abnormal glucose tolerance con-formation,patients with OGTT-1h HG warrant special attention,since about half of them were found to have developed diabetes or IGT,and their risk of suffering from vascular diseases were also increased.
基金supported by National Basic Research Program of China under Grant No.2011CB302400
文摘Tu and Deng proposed a class of bent functions which are of optimal algebraic immunity under the assumption of a combinatorial conjecture.In this paper,the authors compute the dual of the Tu-Deng functions and then show that they are still of optimal algebraic immunity under the assumption of the same conjecture.For another class of Boolean functions constructed by Tang,et al.which are of optimal algebraic immunity with similar forms to Tu-Deng functions,the authors show that they are not bent functions by using some basic properties of binary complete Kloosterman sums.
基金The study was supported by the National Natural Science Foundation of China(Grant No.30170905).
文摘Neural progenitor cells(NPC)are those that are the source of neural cells for cell transplantation and gene therapy.The shortage in quantity and the limited life spans of primary cultured cells limit its widespread use in basic research.Immortalized NPC,which also possess the capacity of self-renewal and can proliferate infinitely,can produce a large number of NPCs with stable phenotype and genotype.Here we report that an immortalized neural progenitor cell strain,which we named as INPC,was suc-cessfully established by gene-transfer of simian virus 40 large T antigen gene mediated by liposomes.The INPC retained the biological characteristics of its original cells and provided a safe and reliable cell platform for the treat-ment of central nervous system diseases and transgenic cell transplantation.INPC could express low levels of MHC antigens which was down-regulated after differentiation.This indicates that INPC possesses poor immunogenicity.The immortalized cells may show good long-term survival and do not elicit an acute immunological response follow-ing transplantation.
基金supported by National Natural Science Foundation of China(No.61203172)the SSTP of Sichuan(Nos.2018YYJC0994 and 2017JY0011)Shenzhen STPP(No.GJHZ20160301164521358)
文摘The parallel computation capabilities of modern graphics processing units （GPUs） have attracted increasing attention from researchers and engineers who have been conducting high computational throughput studies. However, current single GPU based engineering solutions are often struggling to fulfill their real-time requirements. Thus, the multi-GPU-based approach has become a popular and cost-effective choice for tackling the demands. In those cases, the computational load balancing over multiple GPU ＂nodes＂ is often the key and bottleneck that affect the quality and performance of the real=time system. The existing load balancing approaches are mainly based on the assumption that all GPU nodes in the same computer framework are of equal computational performance, which is often not the case due to cluster design and other legacy issues. This paper presents a novel dynamic load balancing （DLB） model for rapid data division and allocation on heterogeneous GPU nodes based on an innovative fuzzy neural network （FNN）. In this research, a 5-state parameter feedback mechanism defining the overall cluster and node performance is proposed. The corresponding FNN-based DLB model will be capable of monitoring and predicting individual node performance under different workload scenarios. A real=time adaptive scheduler has been devised to reorganize the data inputs to each node when necessary to maintain their runtime computational performance. The devised model has been implemented on two dimensional （2D） discrete wavelet transform （DWT） applications for evaluation. Experiment results show that this DLB model enables a high computational throughput while ensuring real=time and precision requirements from complex computational tasks.
