Objective:To explore the molecular biological mechanism of Shugan Jianpi Decoction in treating depression-related breast cancer based on network pharmacology.Methods:The active compounds of Shugan Jianpi Decoction wer...Objective:To explore the molecular biological mechanism of Shugan Jianpi Decoction in treating depression-related breast cancer based on network pharmacology.Methods:The active compounds of Shugan Jianpi Decoction were explored to obtain their drug targets,and the venny network,"TCM-component-target"network,PPI network,"pathway-gene"network,GO and KEGG enrichment results were constructed using relevant softwares.Results:A total of 121 active ingredients,250 genes,2357 GO functions and 184 KEGG pathways were obtained.Conclusion:The active ingredients of Shugan Jianpi Decoction are quercetinll、kaempferol、luteolin、naringenin.The key targets are MAPK1,MAPK3,RELA,and AKT1.GO functions include cellular response to hormone stimulus、cellular response to lipid、cellular response to oxidative stress and so on.KEGG mainly involves PI3K-Akt,microRNAs,and FoxO signaling pathways.This study preliminarily explores the molecular biological mechanism of Shugan Jianpi Decoction in the treatment of depression-related breast cancer,and speculates that it mainly acts by arresting the cell cycle,inhibiting cancer cell proliferation,mediating cancer cell apoptosis,and preventing its recurrence and metastasis,which provides new evidence and new direction for subsequent clinical application and experimental research.展开更多
Reservoirs have been served as the major source of drinking water for dozens of years.The water quality safety of large andmedium reservoirs increasingly becomes the focus of public concern.Field test has proved that ...Reservoirs have been served as the major source of drinking water for dozens of years.The water quality safety of large andmedium reservoirs increasingly becomes the focus of public concern.Field test has proved that water-lifting and aeration system(WLAS)is a piece of effective equipment for in situ control and improvement of water quality.However,its intrinsic bioremediation mechanism,especially for nitrogen removal,still lacks in-depth investigation.Hence,the dynamic changes inwater quality parameters,carbon source metabolism,species compositions and co-occurrence patterns ofmicrobial communitieswere systematically studied in Jinpen Reservoir within a wholeWLAS running cycle.TheWLAS operation could efficiently reduce organic carbon(19.77%),nitrogen(21.55%)and phosphorus(65.60%),respectively.Biolog analysis revealed that the microbialmetabolic capacitieswere enhanced viaWLAS operation,especially in bottomwater.High-throughput sequencing demonstrated that WLAS operation altered the diversity and distributions of microbial communities in the source water.The most dominant genus accountable for aerobic denitrification was identified as Dechloromonas.Furthermore,network analysis revealed that microorganisms interacted more closely through WLAS operation.Oxidation-reduction potential(ORP)and total nitrogen(TN)were regarded as the two main physicochemical parameters influencing microbial community structures,as confirmed by redundancy analysis(RDA)and Mantel test.Overall,the results will provide a scientific basis and an effective way for strengthening the in-situ bioremediation of micro-polluted source water.展开更多
This article is a comprehensive study based on research on the connection between diabetes mellitus(DM)and prostate cancer(PCa).It investigates the potential role of DM as an independent risk factor for PCa,delving in...This article is a comprehensive study based on research on the connection between diabetes mellitus(DM)and prostate cancer(PCa).It investigates the potential role of DM as an independent risk factor for PCa,delving into the biological links,including insulin resistance and hormonal changes.The paper critically analyzes previous studies that have shown varying results and introduces mendelian randomization as a method for establishing causality.It emphasizes the importance of early DM screening and lifestyle modifications in preventing PCa,and proposes future research directions for further understanding the DM-PCa relationship.展开更多
BACKGROUND Musical hallucinations(MH)involve the false perception of music in the absence of external stimuli which links with different etiologies.The pathomechanisms of MH encompass various conditions.The etiologica...BACKGROUND Musical hallucinations(MH)involve the false perception of music in the absence of external stimuli which links with different etiologies.The pathomechanisms of MH encompass various conditions.The etiological classification of MH is of particular importance and offers valuable insights to understand MH,and further to develop the effective treatment of MH.Over the recent decades,more MH cases have been reported,revealing newly identified medical and psychiatric causes of MH.Functional imaging studies reveal that MH activates a wide array of brain regions.An up-to-date analysis on MH,especially on MH comorbid psychiatric conditions is warranted.AIM To propose a new classification of MH;to study the age and gender differences of MH in mental disorders;and neuropathology of MH.METHODS Literatures searches were conducted using keywords such as“music hallucination,”“music hallucination and mental illness,”“music hallucination and gender difference,”and“music hallucination and psychiatric disease”in the databases of PubMed,Google Scholar,and Web of Science.MH cases were collected and categorized based on their etiologies.The t-test and ANOVA were employed(P<0.05)to compare the age differences of MH different etiological groups.Function neuroimaging studies of neural networks regulating MH and their possible molecular mechanisms were discussed.RESULTS Among the 357 yielded publications,294 MH cases were collected.The average age of MH cases was 67.9 years,with a predominance of females(66.8%females vs 33.2%males).MH was classified into eight groups based on their etiological mechanisms.Statistical analysis of MH cases indicates varying associations with psychiatric diagnoses.CONCLUSION We carried out a more comprehensive review of MH studies.For the first time according to our knowledge,we demonstrated the psychiatric conditions linked and/or associated with MH from statistical,biological and molecular point of view.展开更多
Cancer-related fatigue(CRF)is associated with cancer-related anemia(CRA).As the common comorbidities of cancer,both of them can seriously affect the quality of patient life.Yishen Qutong Granules(益肾祛痛颗粒,YSQTG)ha...Cancer-related fatigue(CRF)is associated with cancer-related anemia(CRA).As the common comorbidities of cancer,both of them can seriously affect the quality of patient life.Yishen Qutong Granules(益肾祛痛颗粒,YSQTG)have achieved good curative effects in the treatment of CRA.However,the mechanism of whether it can alleviate CRF needs further confirmation.We used network pharmacology and molecular docking to investigate the molecular mechanism and the effective compounds of the prescription.Through the analysis and research in this paper,we obtained 76 effective compounds and 76 drug-disease intersection targets to construct a network,indicating that quercetin,luteolin,baicalein,β-sitosterol and stigmasterol were possibly the most important compounds in YSQTG.The key targets of YSQTG for CRF were mainly enriched in IL-17 and TNF pathways.816 GO entries and 113 pathways were obtained by GO and KEGG enrichment,respectively,which proved that YSQTG might have a comprehensive therapeutic effect on CRF mainly through regulating IL-17,TNF,MAPK,NF-κB and chemokines,as well as cholinergic synapse and 5-HT synapse pathways.The results of molecular docking showed thatβ-sitosterol and stigmasterol could form PI-Alkyl or Alkyl hydrophobic interactions with CXCL8 and ESR1 at residues LEU25,ARG26,PHE65,ALA69 and LEU346,ALA350,LEU391,PHE404,LEU525,VAL533,respectively.In conclusion,the therapeutic effect of YSQTG on CRF is based on the comprehensive pharmacological effect of multicomponent,multitarget,and multichannel pathways.This study provides a theoretical basis for further experimental research.展开更多
Accumulating operational experience in both aerobic and anaerobic mechanical biological waste treatment （MBT） makes it increasingly obvious that controlled water management would substantially reduce the cost of MBT...Accumulating operational experience in both aerobic and anaerobic mechanical biological waste treatment （MBT） makes it increasingly obvious that controlled water management would substantially reduce the cost of MBT and also enhance resource recovery of the organic and inorganic fraction. The MBT plant at Gescher, Germany, is used as an example in order to determine the quantity and composition of process water and leachates from intensive and subsequent rotting, pressing water from anaerobic digestion and scrubber water from acid exhaust air treatment, and hence prepare an MBT water balance. The potential of, requirements for and limits to internal process water reuse as well as the possibilities of resource recovery from scrubber water are also examined. Finally, an assimilated process water management concept with the purpose of an extensive reduction of wastewater quantity and freshwater demand is presented.展开更多
Based on the biological immune concept, immune response mechanism and expert system, a dynamic and intelligent scheduling model toward the disturbance of the production such as machine fault,task insert and cancel etc...Based on the biological immune concept, immune response mechanism and expert system, a dynamic and intelligent scheduling model toward the disturbance of the production such as machine fault,task insert and cancel etc. Is proposed. The antibody generation method based on the sequence constraints and the coding rule of antibody for the machining procedure is also presented. Using the heuristic antibody generation method based on the physiology immune mechanism, the validity of the scheduling optimization is improved, and based on the immune and expert system under the event-driven constraints, not only Job-shop scheduling problem with multi-objective can be solved, but also the disturbance of the production be handled rapidly. A case of the job-shop scheduling is studied and dynamic optimal solutions with multi-objective function for agile manufacturing are obtained in this paper. And the event-driven dynamic rescheduling result is compared with right-shift rescheduling and total rescheduling.展开更多
Based on the inspiration from Hetu and Luoshu,a principle diagram of pathogenicity of pathogenic factors was established.Accordingly,the inner correlations between pathogenic factor type and biological factors,and bet...Based on the inspiration from Hetu and Luoshu,a principle diagram of pathogenicity of pathogenic factors was established.Accordingly,the inner correlations between pathogenic factor type and biological factors,and between pathogenic factors and host were analyzed.Mechanism of pathogenesis was discussed with five representative cases.The result indicated that effect of biological factors on host could be proved only with the performance of internalization conditions of biological factor and host.The reciprocal transformation between biological factors and pathogenic factors was decided by interaction and state of co-existed factors and host.The results suggested that it is a better and attractive choice to regulate and optimize the host’s state in practice than direct elimination of pathogens with antibiotics.展开更多
Magnesium(Mg)-based materials are a new generation of alloys with the exclusive ability to be biodegradable within the human/animal body.In addition to biodegradability,their inherent biocompatibility and similar-to-b...Magnesium(Mg)-based materials are a new generation of alloys with the exclusive ability to be biodegradable within the human/animal body.In addition to biodegradability,their inherent biocompatibility and similar-to-bone density make Mg-based alloys good candidates for fabricating surgical bioimplants for use in orthopedic and traumatology treatments.To this end,nowadays additive manufacturing(AM)along with three-dimensional(3D)printing represents a promising manufacturing technique as it allows for the integration of bioimplant design and manufacturing processes specific to given applications.Meanwhile,this technique also faces many new challenges associated with the properties of Mg-based alloys,including high chemical reactivity,potential for combustion,and low vaporization temperature.In this review article,various AM processes to fabricate biomedical implants from Mg-based alloys,along with their metallic microstructure,mechanical properties,biodegradability,biocompatibility,and antibacterial properties,as well as various post-AM treatments were critically reviewed.Also,the challenges and issues involved in AM processes from the perspectives of bioimplant design,properties,and applications were identified;the possibilities and potential scope of the Mg-based scaffolds/implants are discussed and highlighted.展开更多
Along with the role transformation of biomaterials from bioinert substitute to regenerative inducer, the biological effect and mechanism of material-organism interaction become more important. Since most of animal tes...Along with the role transformation of biomaterials from bioinert substitute to regenerative inducer, the biological effect and mechanism of material-organism interaction become more important. Since most of animal tests and cellular experiments stay on the phenomenon description instead of mechanism interpretation, the development of proteomics technologies provides a golden opportunity to uncover the molecular interaction mechanism between biomaterial-organism on whole scale. This review summarizes current application of proteomics in biological effect and mechanism study of biomaterials, and discusses the development and challenges for future studies.展开更多
Gallbladder polypoid lesions(GPLs)refer to any elevated lesion of the mucosal surface of the gallbladder wall,and the prevalence is estimated to be between 0.9%and 12.1%.GPLs include benign polyps and malignant polyps...Gallbladder polypoid lesions(GPLs)refer to any elevated lesion of the mucosal surface of the gallbladder wall,and the prevalence is estimated to be between 0.9%and 12.1%.GPLs include benign polyps and malignant polyps.Benign polyps are further classified as non-neoplastic polyps and neoplastic polyps.Cholesterol polyps are the most common benign polyps and adenocarcinoma is the main type of malignant polyp.Hepatitis B virus infection,liver function abnormalities,dyslipidemia,and obesity are the main risk factors for GPLs.Studies of biological mechanisms have focused on malignant gallbladder polyps,the development of which is regulated by hormone levels in vivo,gut microbiota,inflammation,oxidative stress,Salmonella typhimurium,and related molecules.Diagnostic modalities include chemical examination and imaging examination,with imaging examination currently being the mainstay.Treatment of patients with GPLs is based on the presence or absence of symptoms,age,size of the polyps,tendency of the polyp to increase,and risk factors for symptomatic malignancy to determine whether surgery should be performed.展开更多
Acute kidney injury(AKI)is a common and serious health issue with a growing incidence and mortality rate.Tripterygium wilfordii(TW)is a traditional Chinese medicine that has been reported to cause kidney damage.Howeve...Acute kidney injury(AKI)is a common and serious health issue with a growing incidence and mortality rate.Tripterygium wilfordii(TW)is a traditional Chinese medicine that has been reported to cause kidney damage.However,the associated mechanism of TW-induced AKI remains unclear.Therefore,we aimed to uncover the associated mechanisms of AKI induced by TW using network pharmacology and bioinformatics.The candidate compounds of TW and the potential targets were screened using TCMSP and CTD database,and the AKI-related targets were identified from the Dis Ge NET database.The disease targets were intersected with the drug targets,and the Wayne diagram was drawn by Venny 2.1.0 software.We developed proteinprotein interactions(PPI)network and the“disease-compound-target-pathway”network through the Cytoscape software.By using the DAVID database,GO and KEGG enrichment analysis was carried out to reveal the potential signaling pathways of the compound-TW-induced AKI.Meanwhile,the Auto dock vina 1.1.2 was used for molecular docking to verify the active compound and key targets’binding ability.Critical compounds and key targets of TW-induced AKI were identified,including triptolide,kaempferol,β-sitosterol,nobiletin,stigmasterol,TNF,and so on.The GO analysis showed that potential genes’biological function was mainly involved in apoptosis,oxidative stress,and inflammation.Moreover,eight signaling pathways were found,including the HIF-1 signaling pathway,VEGF signaling pathway,apoptosis,and so on.The molecular docking results proved that the core compound’s affinity with the corresponding protein of the gene targets was good.This study preliminarily predicted the core toxic compounds,targets,and related pathways of TW-induced AKI,providing a theoretical basis for the follow-up clinical rational drug use and related research work of TW.展开更多
3D printing has made remarkable progress in soft tissue reconstruction enabling the custom design of complex material implants with patient specific geometry.The aim of this study was to inkjet print mechanically rein...3D printing has made remarkable progress in soft tissue reconstruction enabling the custom design of complex material implants with patient specific geometry.The aim of this study was to inkjet print mechanically reinforced biocompatible hydrogels.Here,we developed a double crosslinked ink by optimizing the rheological properties of solutions of sodium alginate(NaAlg),NaAlg/transglutaminase(TG),CaCl_(2)and gelatin/CaCl_(2).The results showed that a two-component ink system comprising NaAlg(4%w/v)/TG(0.8%w/v)and gelatin(4%w/v)/CaCl_(2)(3%w/v)gave optimum printability.The mechanical and biological properties of printed alginate/gelatin hydrogels prepared from inks with different gelatin contents,and incorporated fibroblasts,were characterized by Scanning Electron Microscope(SEM),mechanical testing and laser confocal microscopy.The compressive moduli of alginate/gelatin hydrogels could be adjusted from 19.2 kPa±1.2 kPa to 65.9 kPa±3.3 kPa by increasing the content of gelatin.After incubation for 7 d,fibroblasts had permeated all printed hydrogels and the rate of proliferation increased with increasing gelatin content.The highest cell proliferation rate(497%)was obtained in a hydrogel containing 4.5%(w/v)gelatin.This study offers a new strategy for the fabrication of 3D structures used to mimic the function of native tissues.展开更多
Mechanical biological treatment(MBT)technology has attracted increasing attention because it can reduce the volume of waste produced.To deal with the current trend of increasing waste,MBT practices are being adopted t...Mechanical biological treatment(MBT)technology has attracted increasing attention because it can reduce the volume of waste produced.To deal with the current trend of increasing waste,MBT practices are being adopted to address waste generated in developing urban societies.In this study,a total of 20 specimens of consolidated undrained triaxial tests were conducted on waste obtained from the Hangzhou Tianziling landfill,China,to evaluate the effect of loading rate on the shear strength parameters of MBT waste.The MBT waste samples exhibited an evident strain-hardening behavior,and no peak was observed even when the axial strain exceeded 25%.Further,the shear strength increased with an increase in the loading rate;the effect of loading rate on shear strength under a low confining pressure was greater than that under a high confining pressure.Furthermore,the shear strength parameters of MBT waste were related to the loading rate.The relationship between the cohesion,internal friction angle,and logarithm of the loading rate could be fitted to a linear relationship,which was established in this study.Finally,the ranges of shear strength parameters cohesion c and effective cohesion c′were determined as 1.0–8.2 kPa and 2.1–14.9 kPa,respectively;the ranges of the internal friction angleφand effective internal friction angleφ’were determined as 16.2°–29°and 19.8°–43.9°,respectively.These results could be used as a valuable reference for conducting stability analyses of MBT landfills.展开更多
Top-geoherbs used in China are always featured with high qualities,and they grow in specified areas with specific environment.Recently,researches on top-geoherbs have attracted increasing attention in China and other ...Top-geoherbs used in China are always featured with high qualities,and they grow in specified areas with specific environment.Recently,researches on top-geoherbs have attracted increasing attention in China and other countries.In order to have a thorough knowledge of top-geoherbs,this article reviews the concept,historical evolution,common trait and quality characteristics of top-geoherbs,and explains the forming mechanism including genetic mechanism and environmental mechanism.In addition,it introduces the influence of human factors on the quality of top-geoherbs.Finally,it proposes some problems that should be paid attention to in the researches on top-geoherbs.展开更多
Aiming at intercepting large maneuvering targets precisely,the guidance law of advanced self-seeking missiles requires not only inertial line-of-sight(LOS)angular rate but also target maneuvering acceleration.Moreover...Aiming at intercepting large maneuvering targets precisely,the guidance law of advanced self-seeking missiles requires not only inertial line-of-sight(LOS)angular rate but also target maneuvering acceleration.Moreover,the semi-strapdown stabilization platform has lost the ability to measure the inertial LOS angular rate directly,which needs to be extracted by numerical calculation.The differential operation commonly used in traditional methods can magnify the measurement error of the sensor,resulting in insufficient calculation accuracy of the line-of-sight angular rate.By analyzing the mathematical relationship between the missile-target relative motion and the angle tracking system,a multi-process-fusion integrated filter model of relative motion and angle tracking is presented.To overcome the defect that the infrared seeker cannot directly measure the missile-target distance,following the snake-hot-eye visual mechanism,a visual bionic imaging guidance method of estimating the missile-target relative distance from the infrared images is proposed to improve the observability of the filter model.Finally,target-tracking simulations verify that the estimation accuracy of target acceleration is improved by four times.展开更多
The process of liver fibrosis changes the rheological properties of liver tissue.This study characterizes and compares liver fibrosis stages from F0 to F4 in rats in terms of shear viscoelastic moduli.Here two viscoel...The process of liver fibrosis changes the rheological properties of liver tissue.This study characterizes and compares liver fibrosis stages from F0 to F4 in rats in terms of shear viscoelastic moduli.Here two viscoelastic models,the Zener model and Voigt model,were applied to experimental data of rheometer tests and then values of elasticity and viscosity were estimated for each fibrosis stage.The results demonstrate that moderate fibrosis（≤F2） has a good correlation with liver viscoelasticity.The mean Zener elasticity E1 increases from（0.452±0.094） kPa（F0） to（1.311±0.717） kPa（F2）,while the mean Voigt elasticity E increases from（0.618±0.089） kPa（F0） to（1.701±0.844） kPa（F2）.The mean Zener viscosity increases from（3.499±0.186） Pa·s（F0） to（4.947±1.811） Pa·s（F2） and the mean Voigt viscosity increases from（3.379±0.316） Pa·s（F0） to（4.625±1.296） Pa·s（F2）.Compared with viscosity,the elasticity shows smaller variations at stages F1 and F2 no matter what viscoelastic model is used.Therefore,the estimated elasticity is more effective than viscosity for differentiating the fibrosis stages from F0 to F2.展开更多
基金National Science Fund Subsidized Project(No.81774289)。
文摘Objective:To explore the molecular biological mechanism of Shugan Jianpi Decoction in treating depression-related breast cancer based on network pharmacology.Methods:The active compounds of Shugan Jianpi Decoction were explored to obtain their drug targets,and the venny network,"TCM-component-target"network,PPI network,"pathway-gene"network,GO and KEGG enrichment results were constructed using relevant softwares.Results:A total of 121 active ingredients,250 genes,2357 GO functions and 184 KEGG pathways were obtained.Conclusion:The active ingredients of Shugan Jianpi Decoction are quercetinll、kaempferol、luteolin、naringenin.The key targets are MAPK1,MAPK3,RELA,and AKT1.GO functions include cellular response to hormone stimulus、cellular response to lipid、cellular response to oxidative stress and so on.KEGG mainly involves PI3K-Akt,microRNAs,and FoxO signaling pathways.This study preliminarily explores the molecular biological mechanism of Shugan Jianpi Decoction in the treatment of depression-related breast cancer,and speculates that it mainly acts by arresting the cell cycle,inhibiting cancer cell proliferation,mediating cancer cell apoptosis,and preventing its recurrence and metastasis,which provides new evidence and new direction for subsequent clinical application and experimental research.
基金This work was supported by the National Key Research and Development Program of China(No.2019YFD1100101)the National Natural Science Foundation of China(No.51979217)+2 种基金the Shaanxi Provincial Key Research and Development Program(No.2019ZDLSF06-03)the Youth Innovation Team of Shaanxi Universities in 2020(PI:Dr.Haihan Zhang)the Youth Innovation Team of Shaanxi Universities in 2021(No.21JP061).
文摘Reservoirs have been served as the major source of drinking water for dozens of years.The water quality safety of large andmedium reservoirs increasingly becomes the focus of public concern.Field test has proved that water-lifting and aeration system(WLAS)is a piece of effective equipment for in situ control and improvement of water quality.However,its intrinsic bioremediation mechanism,especially for nitrogen removal,still lacks in-depth investigation.Hence,the dynamic changes inwater quality parameters,carbon source metabolism,species compositions and co-occurrence patterns ofmicrobial communitieswere systematically studied in Jinpen Reservoir within a wholeWLAS running cycle.TheWLAS operation could efficiently reduce organic carbon(19.77%),nitrogen(21.55%)and phosphorus(65.60%),respectively.Biolog analysis revealed that the microbialmetabolic capacitieswere enhanced viaWLAS operation,especially in bottomwater.High-throughput sequencing demonstrated that WLAS operation altered the diversity and distributions of microbial communities in the source water.The most dominant genus accountable for aerobic denitrification was identified as Dechloromonas.Furthermore,network analysis revealed that microorganisms interacted more closely through WLAS operation.Oxidation-reduction potential(ORP)and total nitrogen(TN)were regarded as the two main physicochemical parameters influencing microbial community structures,as confirmed by redundancy analysis(RDA)and Mantel test.Overall,the results will provide a scientific basis and an effective way for strengthening the in-situ bioremediation of micro-polluted source water.
文摘This article is a comprehensive study based on research on the connection between diabetes mellitus(DM)and prostate cancer(PCa).It investigates the potential role of DM as an independent risk factor for PCa,delving into the biological links,including insulin resistance and hormonal changes.The paper critically analyzes previous studies that have shown varying results and introduces mendelian randomization as a method for establishing causality.It emphasizes the importance of early DM screening and lifestyle modifications in preventing PCa,and proposes future research directions for further understanding the DM-PCa relationship.
文摘BACKGROUND Musical hallucinations(MH)involve the false perception of music in the absence of external stimuli which links with different etiologies.The pathomechanisms of MH encompass various conditions.The etiological classification of MH is of particular importance and offers valuable insights to understand MH,and further to develop the effective treatment of MH.Over the recent decades,more MH cases have been reported,revealing newly identified medical and psychiatric causes of MH.Functional imaging studies reveal that MH activates a wide array of brain regions.An up-to-date analysis on MH,especially on MH comorbid psychiatric conditions is warranted.AIM To propose a new classification of MH;to study the age and gender differences of MH in mental disorders;and neuropathology of MH.METHODS Literatures searches were conducted using keywords such as“music hallucination,”“music hallucination and mental illness,”“music hallucination and gender difference,”and“music hallucination and psychiatric disease”in the databases of PubMed,Google Scholar,and Web of Science.MH cases were collected and categorized based on their etiologies.The t-test and ANOVA were employed(P<0.05)to compare the age differences of MH different etiological groups.Function neuroimaging studies of neural networks regulating MH and their possible molecular mechanisms were discussed.RESULTS Among the 357 yielded publications,294 MH cases were collected.The average age of MH cases was 67.9 years,with a predominance of females(66.8%females vs 33.2%males).MH was classified into eight groups based on their etiological mechanisms.Statistical analysis of MH cases indicates varying associations with psychiatric diagnoses.CONCLUSION We carried out a more comprehensive review of MH studies.For the first time according to our knowledge,we demonstrated the psychiatric conditions linked and/or associated with MH from statistical,biological and molecular point of view.
基金the Capital Health Development Scientific Research Project(2020-2-4026)Clinical and Translational Medicine Research Fund Projects of Cancer Hospital of Chinese Academy of Medical Science(2019XK320072)
文摘Cancer-related fatigue(CRF)is associated with cancer-related anemia(CRA).As the common comorbidities of cancer,both of them can seriously affect the quality of patient life.Yishen Qutong Granules(益肾祛痛颗粒,YSQTG)have achieved good curative effects in the treatment of CRA.However,the mechanism of whether it can alleviate CRF needs further confirmation.We used network pharmacology and molecular docking to investigate the molecular mechanism and the effective compounds of the prescription.Through the analysis and research in this paper,we obtained 76 effective compounds and 76 drug-disease intersection targets to construct a network,indicating that quercetin,luteolin,baicalein,β-sitosterol and stigmasterol were possibly the most important compounds in YSQTG.The key targets of YSQTG for CRF were mainly enriched in IL-17 and TNF pathways.816 GO entries and 113 pathways were obtained by GO and KEGG enrichment,respectively,which proved that YSQTG might have a comprehensive therapeutic effect on CRF mainly through regulating IL-17,TNF,MAPK,NF-κB and chemokines,as well as cholinergic synapse and 5-HT synapse pathways.The results of molecular docking showed thatβ-sitosterol and stigmasterol could form PI-Alkyl or Alkyl hydrophobic interactions with CXCL8 and ESR1 at residues LEU25,ARG26,PHE65,ALA69 and LEU346,ALA350,LEU391,PHE404,LEU525,VAL533,respectively.In conclusion,the therapeutic effect of YSQTG on CRF is based on the comprehensive pharmacological effect of multicomponent,multitarget,and multichannel pathways.This study provides a theoretical basis for further experimental research.
文摘Accumulating operational experience in both aerobic and anaerobic mechanical biological waste treatment （MBT） makes it increasingly obvious that controlled water management would substantially reduce the cost of MBT and also enhance resource recovery of the organic and inorganic fraction. The MBT plant at Gescher, Germany, is used as an example in order to determine the quantity and composition of process water and leachates from intensive and subsequent rotting, pressing water from anaerobic digestion and scrubber water from acid exhaust air treatment, and hence prepare an MBT water balance. The potential of, requirements for and limits to internal process water reuse as well as the possibilities of resource recovery from scrubber water are also examined. Finally, an assimilated process water management concept with the purpose of an extensive reduction of wastewater quantity and freshwater demand is presented.
基金This work was supported by National Science Foundation of Shanghai(02ZF14003)
文摘Based on the biological immune concept, immune response mechanism and expert system, a dynamic and intelligent scheduling model toward the disturbance of the production such as machine fault,task insert and cancel etc. Is proposed. The antibody generation method based on the sequence constraints and the coding rule of antibody for the machining procedure is also presented. Using the heuristic antibody generation method based on the physiology immune mechanism, the validity of the scheduling optimization is improved, and based on the immune and expert system under the event-driven constraints, not only Job-shop scheduling problem with multi-objective can be solved, but also the disturbance of the production be handled rapidly. A case of the job-shop scheduling is studied and dynamic optimal solutions with multi-objective function for agile manufacturing are obtained in this paper. And the event-driven dynamic rescheduling result is compared with right-shift rescheduling and total rescheduling.
基金Supported by National Natural Science Foundation of China(30560107)
文摘Based on the inspiration from Hetu and Luoshu,a principle diagram of pathogenicity of pathogenic factors was established.Accordingly,the inner correlations between pathogenic factor type and biological factors,and between pathogenic factors and host were analyzed.Mechanism of pathogenesis was discussed with five representative cases.The result indicated that effect of biological factors on host could be proved only with the performance of internalization conditions of biological factor and host.The reciprocal transformation between biological factors and pathogenic factors was decided by interaction and state of co-existed factors and host.The results suggested that it is a better and attractive choice to regulate and optimize the host’s state in practice than direct elimination of pathogens with antibiotics.
文摘Magnesium(Mg)-based materials are a new generation of alloys with the exclusive ability to be biodegradable within the human/animal body.In addition to biodegradability,their inherent biocompatibility and similar-to-bone density make Mg-based alloys good candidates for fabricating surgical bioimplants for use in orthopedic and traumatology treatments.To this end,nowadays additive manufacturing(AM)along with three-dimensional(3D)printing represents a promising manufacturing technique as it allows for the integration of bioimplant design and manufacturing processes specific to given applications.Meanwhile,this technique also faces many new challenges associated with the properties of Mg-based alloys,including high chemical reactivity,potential for combustion,and low vaporization temperature.In this review article,various AM processes to fabricate biomedical implants from Mg-based alloys,along with their metallic microstructure,mechanical properties,biodegradability,biocompatibility,and antibacterial properties,as well as various post-AM treatments were critically reviewed.Also,the challenges and issues involved in AM processes from the perspectives of bioimplant design,properties,and applications were identified;the possibilities and potential scope of the Mg-based scaffolds/implants are discussed and highlighted.
基金support of Natural Science Foundation of Guangdong Province, China (Nos. 2016A030310245 and 2016A030310244)China Postdoctoral Science Foundation (No. 2016M591017)Key Projects in the National Science &Technology Pillar program during the thirteenth Five-year Plan Period (No. 2016YFC1102800)
文摘Along with the role transformation of biomaterials from bioinert substitute to regenerative inducer, the biological effect and mechanism of material-organism interaction become more important. Since most of animal tests and cellular experiments stay on the phenomenon description instead of mechanism interpretation, the development of proteomics technologies provides a golden opportunity to uncover the molecular interaction mechanism between biomaterial-organism on whole scale. This review summarizes current application of proteomics in biological effect and mechanism study of biomaterials, and discusses the development and challenges for future studies.
基金funded by Jiangsu Province-Establishment of an endoscopic diagnosis and treatment system for submucosal tumors of the digestive tract and optimization of key technologies(No.BE2019667).
文摘Gallbladder polypoid lesions(GPLs)refer to any elevated lesion of the mucosal surface of the gallbladder wall,and the prevalence is estimated to be between 0.9%and 12.1%.GPLs include benign polyps and malignant polyps.Benign polyps are further classified as non-neoplastic polyps and neoplastic polyps.Cholesterol polyps are the most common benign polyps and adenocarcinoma is the main type of malignant polyp.Hepatitis B virus infection,liver function abnormalities,dyslipidemia,and obesity are the main risk factors for GPLs.Studies of biological mechanisms have focused on malignant gallbladder polyps,the development of which is regulated by hormone levels in vivo,gut microbiota,inflammation,oxidative stress,Salmonella typhimurium,and related molecules.Diagnostic modalities include chemical examination and imaging examination,with imaging examination currently being the mainstay.Treatment of patients with GPLs is based on the presence or absence of symptoms,age,size of the polyps,tendency of the polyp to increase,and risk factors for symptomatic malignancy to determine whether surgery should be performed.
基金The Science Foundation of Health and Family Planning Commission of Jiangxi Province(Grant No.20181140)the Science and Technology Research Project of Jiangxi Provincial Department of Education(Grant No.GJJ201819,180919)。
文摘Acute kidney injury(AKI)is a common and serious health issue with a growing incidence and mortality rate.Tripterygium wilfordii(TW)is a traditional Chinese medicine that has been reported to cause kidney damage.However,the associated mechanism of TW-induced AKI remains unclear.Therefore,we aimed to uncover the associated mechanisms of AKI induced by TW using network pharmacology and bioinformatics.The candidate compounds of TW and the potential targets were screened using TCMSP and CTD database,and the AKI-related targets were identified from the Dis Ge NET database.The disease targets were intersected with the drug targets,and the Wayne diagram was drawn by Venny 2.1.0 software.We developed proteinprotein interactions(PPI)network and the“disease-compound-target-pathway”network through the Cytoscape software.By using the DAVID database,GO and KEGG enrichment analysis was carried out to reveal the potential signaling pathways of the compound-TW-induced AKI.Meanwhile,the Auto dock vina 1.1.2 was used for molecular docking to verify the active compound and key targets’binding ability.Critical compounds and key targets of TW-induced AKI were identified,including triptolide,kaempferol,β-sitosterol,nobiletin,stigmasterol,TNF,and so on.The GO analysis showed that potential genes’biological function was mainly involved in apoptosis,oxidative stress,and inflammation.Moreover,eight signaling pathways were found,including the HIF-1 signaling pathway,VEGF signaling pathway,apoptosis,and so on.The molecular docking results proved that the core compound’s affinity with the corresponding protein of the gene targets was good.This study preliminarily predicted the core toxic compounds,targets,and related pathways of TW-induced AKI,providing a theoretical basis for the follow-up clinical rational drug use and related research work of TW.
基金This work was supported by the Development Projects of Key Research(No.2018YFE0207900)People’s Liberation Army(No.BWS17J036,18-163-13-ZT-003-011-01)the National Natural Science Foundation of China(Nos.51835010 and 51375371).
文摘3D printing has made remarkable progress in soft tissue reconstruction enabling the custom design of complex material implants with patient specific geometry.The aim of this study was to inkjet print mechanically reinforced biocompatible hydrogels.Here,we developed a double crosslinked ink by optimizing the rheological properties of solutions of sodium alginate(NaAlg),NaAlg/transglutaminase(TG),CaCl_(2)and gelatin/CaCl_(2).The results showed that a two-component ink system comprising NaAlg(4%w/v)/TG(0.8%w/v)and gelatin(4%w/v)/CaCl_(2)(3%w/v)gave optimum printability.The mechanical and biological properties of printed alginate/gelatin hydrogels prepared from inks with different gelatin contents,and incorporated fibroblasts,were characterized by Scanning Electron Microscope(SEM),mechanical testing and laser confocal microscopy.The compressive moduli of alginate/gelatin hydrogels could be adjusted from 19.2 kPa±1.2 kPa to 65.9 kPa±3.3 kPa by increasing the content of gelatin.After incubation for 7 d,fibroblasts had permeated all printed hydrogels and the rate of proliferation increased with increasing gelatin content.The highest cell proliferation rate(497%)was obtained in a hydrogel containing 4.5%(w/v)gelatin.This study offers a new strategy for the fabrication of 3D structures used to mimic the function of native tissues.
基金funded by the National Natural Science Foundation of China(Nos.51978625 and 51678532)the Zhejiang Provincial Natural Science Foundation of China(No.LZ21E080003)。
文摘Mechanical biological treatment(MBT)technology has attracted increasing attention because it can reduce the volume of waste produced.To deal with the current trend of increasing waste,MBT practices are being adopted to address waste generated in developing urban societies.In this study,a total of 20 specimens of consolidated undrained triaxial tests were conducted on waste obtained from the Hangzhou Tianziling landfill,China,to evaluate the effect of loading rate on the shear strength parameters of MBT waste.The MBT waste samples exhibited an evident strain-hardening behavior,and no peak was observed even when the axial strain exceeded 25%.Further,the shear strength increased with an increase in the loading rate;the effect of loading rate on shear strength under a low confining pressure was greater than that under a high confining pressure.Furthermore,the shear strength parameters of MBT waste were related to the loading rate.The relationship between the cohesion,internal friction angle,and logarithm of the loading rate could be fitted to a linear relationship,which was established in this study.Finally,the ranges of shear strength parameters cohesion c and effective cohesion c′were determined as 1.0–8.2 kPa and 2.1–14.9 kPa,respectively;the ranges of the internal friction angleφand effective internal friction angleφ’were determined as 16.2°–29°and 19.8°–43.9°,respectively.These results could be used as a valuable reference for conducting stability analyses of MBT landfills.
文摘Top-geoherbs used in China are always featured with high qualities,and they grow in specified areas with specific environment.Recently,researches on top-geoherbs have attracted increasing attention in China and other countries.In order to have a thorough knowledge of top-geoherbs,this article reviews the concept,historical evolution,common trait and quality characteristics of top-geoherbs,and explains the forming mechanism including genetic mechanism and environmental mechanism.In addition,it introduces the influence of human factors on the quality of top-geoherbs.Finally,it proposes some problems that should be paid attention to in the researches on top-geoherbs.
基金sponsored by the National Natural Science Foundation of China under Grant No.51979275the Joint Open Research Fund Program of State Key Laboratory of Hydroscience and Engineering and Tsinghua—Ningxia Yinchuan Joint Institute of Internet of Waters on Digital Water Governance under Grant No.sklhse-2022-Iow08+2 种基金the Open Fund of Key Laboratory of Urban Land Resources Monitoring and Simulation,Ministry of Natural Resources under Grant No.KF-2021-06-115the National Key R&D Program of China under Grant No.2018YFD0700603the 2115 Talent Development Program of China Agricultural University.
文摘Aiming at intercepting large maneuvering targets precisely,the guidance law of advanced self-seeking missiles requires not only inertial line-of-sight(LOS)angular rate but also target maneuvering acceleration.Moreover,the semi-strapdown stabilization platform has lost the ability to measure the inertial LOS angular rate directly,which needs to be extracted by numerical calculation.The differential operation commonly used in traditional methods can magnify the measurement error of the sensor,resulting in insufficient calculation accuracy of the line-of-sight angular rate.By analyzing the mathematical relationship between the missile-target relative motion and the angle tracking system,a multi-process-fusion integrated filter model of relative motion and angle tracking is presented.To overcome the defect that the infrared seeker cannot directly measure the missile-target distance,following the snake-hot-eye visual mechanism,a visual bionic imaging guidance method of estimating the missile-target relative distance from the infrared images is proposed to improve the observability of the filter model.Finally,target-tracking simulations verify that the estimation accuracy of target acceleration is improved by four times.
基金supported by the National Natural Science Foundation of China(Nos.61031003,81271651,and 61101025)the Shenzhen Basic Research Project(No.JC201005280501A),China
文摘The process of liver fibrosis changes the rheological properties of liver tissue.This study characterizes and compares liver fibrosis stages from F0 to F4 in rats in terms of shear viscoelastic moduli.Here two viscoelastic models,the Zener model and Voigt model,were applied to experimental data of rheometer tests and then values of elasticity and viscosity were estimated for each fibrosis stage.The results demonstrate that moderate fibrosis（≤F2） has a good correlation with liver viscoelasticity.The mean Zener elasticity E1 increases from（0.452±0.094） kPa（F0） to（1.311±0.717） kPa（F2）,while the mean Voigt elasticity E increases from（0.618±0.089） kPa（F0） to（1.701±0.844） kPa（F2）.The mean Zener viscosity increases from（3.499±0.186） Pa·s（F0） to（4.947±1.811） Pa·s（F2） and the mean Voigt viscosity increases from（3.379±0.316） Pa·s（F0） to（4.625±1.296） Pa·s（F2）.Compared with viscosity,the elasticity shows smaller variations at stages F1 and F2 no matter what viscoelastic model is used.Therefore,the estimated elasticity is more effective than viscosity for differentiating the fibrosis stages from F0 to F2.
