期刊文献+
共找到3,929篇文章
< 1 2 197 >
每页显示 20 50 100
The role of AFAP1-AS1 in mitotic catastrophe and metastasis of triple-negative breast cancer cells by activating the PLK1 signaling pathway
1
作者 SHUIZHONG CEN XIAOJIE PENG +9 位作者 JIANWEN DENG HAIYUN JIN ZHINAN DENG XIAOHUA LIN DI ZHU MING JIN YANWEN ZHU PUSHENG ZHANG YUNFENG LUO HONGYAN HUANG 《Oncology Research》 SCIE 2023年第3期375-388,共14页
Triple-negative breast cancer(TNBC)is characterized by fast growth,high metastasis,high invasion,and a lack of therapeutic targets.Mitosis and metastasis of TNBC cells are two important biological behaviors in TNBC ma... Triple-negative breast cancer(TNBC)is characterized by fast growth,high metastasis,high invasion,and a lack of therapeutic targets.Mitosis and metastasis of TNBC cells are two important biological behaviors in TNBC malignant progression.It is well known that the long noncoding RNA AFAP1-AS1 plays a crucial role in various tumors,but whether AFAP1-AS1 is involved in the mitosis of TNBC cells remains unknown.In this study,we investigated the functional mechanism of AFAP1-AS1 in targeting Polo-like Kinase 1(PLK1)activation and participating in mitosis of TNBC cells.We detected the expression of AFAP1-AS1 in the TNBC patient cohort and primary cells by in situ hybridization(ISH),northern blot,fluorescent in situ hybridization(FISH)and cell nucleus/cytoplasm RNA fraction isolation.High AFAP1-AS1 expression was negatively correlated with overall survival(OS),disease-free survival(DFS),metastasis-free survival(MFS)and recurrence-free survival(RFS)in TNBC patients.We explored the function of AFAP1-AS1 by transwell,apoptosis,immunofluorescence(IF)and patient-derived xenograft(PDX)models in vitro and in vivo.We found that AFAP1-AS1 promoted TNBC primary cell survival by inhibiting mitotic catastrophe and increased TNBC primary cell growth,migration and invasion.Mechanistically,AFAP1-AS1 activated phosphorylation of the mitosis-associated kinase PLK1 protein.Elevated levels of AFAP1-AS1 in TNBC primary cells increased PLK1 pathway downstream gene expression,such as CDC25C,CDK1,BUB1 and TTK.More importantly,AFAP1-AS1 increased lung metastases in a mouse metastasis model.Taken together,AFAP1-AS1 functions as an oncogene that activates the PLK1 signaling pathway.AFAP1-AS1 could be used as a potential prognostic marker and therapeutic target for TNBC. 展开更多
关键词 TNBC AFAP1-AS1 Mitotic catastrophe METASTASIS PLK1
下载PDF
Mitotic Catastrophe的研究进展 被引量:2
2
作者 张博 周平坤 《细胞生物学杂志》 CSCD 2007年第6期849-852,共4页
细胞死亡是多细胞生物生命过程中重要的生理或病理现象,可分为坏死和程序性细胞死亡,而后者根据死亡细胞的形态学和发生机制的不同又可分为凋亡、自吞噬和mitotic catastrophe,其中mitotic catastrophe是近年来才被揭示报道,是指细胞在... 细胞死亡是多细胞生物生命过程中重要的生理或病理现象,可分为坏死和程序性细胞死亡,而后者根据死亡细胞的形态学和发生机制的不同又可分为凋亡、自吞噬和mitotic catastrophe,其中mitotic catastrophe是近年来才被揭示报道,是指细胞在有丝分裂过程中死亡的现象,是一种发生在细胞有丝分裂期由于异常的细胞分裂而导致的细胞死亡,它常常伴随着细胞有丝分裂检查点的异常和基因或纺锤体结构的损伤而发生。现对mitotic catastrophe及相关的调控机制进行综述。 展开更多
关键词 MITOTIC catastrophe DNA损伤 细胞周期检查点 纺锤体
下载PDF
Establishment and Application of Assessment Indicator System of Agricultural Catastrophe Vulnerability
3
作者 LUO Hua-wei WANG Yi 《Asian Agricultural Research》 2012年第4期3-8,共6页
To give play to the role of agricultural catastrophe risk fund in spreading agricultural catastrophe risk,we select natural conditions,economic conditions,social conditions,as the external vulnerability assessment ind... To give play to the role of agricultural catastrophe risk fund in spreading agricultural catastrophe risk,we select natural conditions,economic conditions,social conditions,as the external vulnerability assessment indicators;select commodity rate of agricultural products,substitutability of agricultural products,the extent of agricultural products being related to the national economy and the people's livelihood,as the internal vulnerability assessment indicators.We assign weight to indicators using Analytic Hierarchy Process,and establish assessment indicator system of agricultural catastrophe vulnerability,to analyze the compensation for losses of different agricultural products arising from agricultural catastrophe in different regions.And we take the case of rice in Sichuan Province,to demonstrate the role this indicator system. 展开更多
关键词 Agricultural catastrophe risk fund Assessment indicator system of agricultural catastrophe vulnerability Analytic Hierarchy Process
下载PDF
The Study of Chamber Rockburst by the CUSP Model of Catastrophe Theory 被引量:4
4
作者 潘一山 章梦涛 李国臻 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 1994年第10期943-951,共9页
THESTUDYOFCHAMBERROCKBURSTBYTHECUSPMODELOFCATASTROPHETHEORYPanYi-shan(潘一山),ZhangMeng-tao(章梦涛),LiGuo-zheng(李国... THESTUDYOFCHAMBERROCKBURSTBYTHECUSPMODELOFCATASTROPHETHEORYPanYi-shan(潘一山),ZhangMeng-tao(章梦涛),LiGuo-zheng(李国臻)(FuxinMininqIns... 展开更多
关键词 rockburst. CUSP model of catastrophe theory. critical depth ofplastic SOFTENING area. displacement jump. energy LIBERATION
下载PDF
DESCRIPTION AND PREDICTION OF CATASTROPHE OF VIBRATION STATE FOR FAULTY ROTORS 被引量:5
5
作者 Chen Anhua Zhong Jue 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 1996年第1期130-134,共5页
A sudden increase of vibration amplitude with no foreboding often results in an abrupt breakdown of a mechanical system.The catastrophe of vibration state of a faulty rotor is a typical nonlinear phenomenon,and very d... A sudden increase of vibration amplitude with no foreboding often results in an abrupt breakdown of a mechanical system.The catastrophe of vibration state of a faulty rotor is a typical nonlinear phenomenon,and very difficult to be described and predicted with linear vibration theory.On the basis of nonlinear vibration and catastrophe theory,fhe eatastrophe of the vibration amplitude of the faulty rotor is described;a way to predict its emergence is developed. 展开更多
关键词 mechanical fault diagnosis and prediction cusp catastrophe model nonlinear vibration rotor
下载PDF
A CATASTROPHE ANALYSIS ON THE STABILITY OF THE CRACK GROWTH IN THREE-POINT BENDING SPECIMENS 被引量:2
6
作者 Wei Demin Fan Xuejun, Taiyuan Unversity of Technology, Taiyuan 030024 《Acta Mechanica Solida Sinica》 SCIE EI 1996年第2期179-183,共5页
This paper presents an attempt at the application of catastrophe theory to the stabilityanalysis of J-controlled crack growth in three-point bending specimens. By introducing the solutions ofJ-integral in the complete... This paper presents an attempt at the application of catastrophe theory to the stabilityanalysis of J-controlled crack growth in three-point bending specimens. By introducing the solutions ofJ-integral in the completely yielding state for the ideal plastic material, the critical condition of losingstability for the crack propagation in the specimen is obtained, based on the cusp catastrophe theory.The process of the crack growth from geometrical sense is described. 展开更多
关键词 crack growth stability CUSP catastrophe J-INTEGRAL three-point BENDING SPECIMEN
下载PDF
GEOGRAPHIC ENVIRONMENT CHANGE AND FLOOD CATASTROPHE IN HUAIHE RIVER BASIN DURING LAST 2000 YEARS 被引量:1
7
作者 杨达源 王云飞 《Chinese Geographical Science》 SCIE CSCD 1996年第2期112-119,共8页
GEOGRAPHIC ENVIRONMENT CHANGE AND FLOOD CATASTROPHE IN HUAIHE RIVER BASIN DURING LAST 2000 YEARSYangDayuan(杨... GEOGRAPHIC ENVIRONMENT CHANGE AND FLOOD CATASTROPHE IN HUAIHE RIVER BASIN DURING LAST 2000 YEARSYangDayuan(杨达源)(DepartmentofG... 展开更多
关键词 Hongze Lake headward accumulation MIDDLE reaches of the Huaihe RIVER FLOOD catastrophe
下载PDF
CUSP CATASTROPHE MODEL OF INSTABILITY OF PILLAR IN ASYMMETRIC MINING 被引量:20
8
作者 李江腾 曹平 《应用数学和力学》 EI CSCD 北大核心 2005年第8期1003-1008,共6页
关键词 矿柱 稳定性 势能 尖点突变 非对称开采
下载PDF
A MODEL OF BUTTERFLY CATASTROPHE FOR ANODE EFFECT IN ALUMINA ELECTROLYSIS
9
作者 PAN Yue Qingdao University of Metallurgy and Mining 《Acta Metallurgica Sinica(English Letters)》 SCIE EI CAS CSCD 1991年第8期82-87,共6页
A model of butterfly catastrophe is confirmed based on the matching and fitting the previousexperimental data from alumina electrolysis when anode effect occurs.The complicatedbehaviour of the cryolite-alumina melt sy... A model of butterfly catastrophe is confirmed based on the matching and fitting the previousexperimental data from alumina electrolysis when anode effect occurs.The complicatedbehaviour of the cryolite-alumina melt system with varying parameters could be generallydescribed by this model.Therefore,the anode effect and its occurrence may be thoroughlyunderstood. 展开更多
关键词 ALUMINA ELECTROLYSIS ANODE effect BUTTERFLY catastrophe model
下载PDF
CATASTROPHE FRACTURE OF THIN-WALL PRESSURE TUBES
10
作者 WEI De-min(魏德敏) +1 位作者 YANG Gui-tong(杨桂通) 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 2002年第2期146-149,共4页
Catastrophe theory was used to investigate the fracture behavior of thin_wall cylindrical tubes subjected to internal explosive pressure. Based on the energy theory and catastrophe theory, a cusp catastrophe model for... Catastrophe theory was used to investigate the fracture behavior of thin_wall cylindrical tubes subjected to internal explosive pressure. Based on the energy theory and catastrophe theory, a cusp catastrophe model for the fracture was established, and a critical condition associated with the model is given. 展开更多
关键词 pressure tube BRITTLE FRACTURE CUSP catastrophe BIFURCATION set
下载PDF
PANSYSTEMS LOGIC CONSERVATION OF BIFURCATION,CATASTROPHE,CHAOS AND STABILITY
11
作者 吴陈 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 1993年第4期367-370,共4页
It is in references[4,5]that the combination of the relative researches of pansystems methodology and the researches of bifurcation,catastrophe,chaos and stability in nonlinear mechanics was put forward and the concep... It is in references[4,5]that the combination of the relative researches of pansystems methodology and the researches of bifurcation,catastrophe,chaos and stability in nonlinear mechanics was put forward and the concepts were redefined from the point of view of pansystems methodology.The present paper studies the logic conservation law of these nonlinear mechanics phenomena under the framework of pansystems methodology. 展开更多
关键词 pansystems methodology BIFURCATION catastrophe CHAOS and STABILITY nonlinear mechanics pansystems LOGIC CONSERVATION law
下载PDF
Research on Instability Mechanism and Type of Ore Pillar Based on the Fold Catastrophe Theory
12
作者 Zhengzheng Cao Feng Du +3 位作者 Zhenhua Li Qinting Wang Ping Xu Haixiao Lin 《Computer Modeling in Engineering & Sciences》 SCIE EI 2017年第3期275-293,共19页
The stability of ore pillar in mine is essential for the safe and efficient mining.Based on the energy evolvement rule in ore pillar and roadway roof system,the roadway roof and ore pillar are treated as energy releas... The stability of ore pillar in mine is essential for the safe and efficient mining.Based on the energy evolvement rule in ore pillar and roadway roof system,the roadway roof and ore pillar are treated as energy release body and energy dissipation body,respectively.Therefore,the double-block mechanical model is established with energy dissipation body and energy release body,and the energy mechanism of ore pillar instability is obtained,based on the fold catastrophe mathematical theory.The research result indicates that the dynamic instability of ore pillar is a physical instability problem caused by the strain softening property of ore mass,and the instability type of ore pillar is determined by the stiffness parameter of double-block mechanical system.When the systematical stiffness parameter is greater than or equal to 1,the equilibrium position of double-block mechanical system passes through shaft K-1 or the origin,from branch 1 of unstable equilibrium state to branch 2 of stable equilibrium state by smooth transition,and the ore pillar shows quasi-static fracture.When the systematical stiffness parameter is less than 1,the equilibrium position of double-block system mutates from branch 1 of unstable equilibrium state to branch 2 of stable equilibrium state by jumping transition,and the ore pillar shows dynamic instability.The research result could provide theoretical guidance for the prevention measures of ore pillar instability. 展开更多
关键词 ORE PILLAR instability mechanism double-block mechanical model systematical stiffness FOLD catastrophe THEORY
下载PDF
Transition State and Catastrophe Set
13
作者 Fang Jianyun Tang Auchin (Institute of Theoretical Chemistry, Jilin University, Changchun) 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 1991年第1期65-66,共2页
The study on transition states is one of the most important pathways to understand the essence of chemical reactions. With the development of femtoseeond pulse technique, Zewail et al. have carried out a number of exp... The study on transition states is one of the most important pathways to understand the essence of chemical reactions. With the development of femtoseeond pulse technique, Zewail et al. have carried out a number of experimental studies on the transition states, while the theoretical chemists has a great interest in the topic. In the 展开更多
关键词 TRANSITION STATE catastrophe SET STATE VARIABLE
下载PDF
Analysis of main shock of thrust fault earthquake by catastrophe theory
14
作者 潘岳 赵志刚 《Applied Mathematics and Mechanics(English Edition)》 SCIE EI 2012年第7期845-864,共20页
The relationship between work and energy increment of a thrust fault system with quasi-static deformation can be decomposed into two parts: volume strain energy and deviation stress energy. The relationship between wo... The relationship between work and energy increment of a thrust fault system with quasi-static deformation can be decomposed into two parts: volume strain energy and deviation stress energy. The relationship between work and energy increment of the deviation stress of a simplified thrust fault system is analyzed based on the catastrophe theory. The research indicates that the characteristics displayed by the fold catastrophe model can appropriately describe the condition of earthquake generation, the evolvement process of main shock of thrust fault earthquake, and some important aftershock properties. The bigger the surrounding press of surrounding rock is, the bigger the maximum principal stress is, the smaller the incidences of the potential thrust fault surface are, and the smaller the ratio between the tangential stiffness of surrounding rock and the slope is, which is at the inflexion point on the softened zone of the fault shearing strength curve. Thus, when earthquake occurrs, the larger the elastic energy releasing amount of surrounding rock is, the bigger the earthquake magnitude is, the larger the half distance of fault dislocation is, and the larger the displacement amplitude of end face of surrounding rock is. Fracturing and expanding the fault rock body and releasing the volume strain energy of surrounding rock during the earthquake can enhance the foregoing effects together. 展开更多
关键词 thrust fault EARTHQUAKE fold catastrophe model elastic energy releasing amount distance of fault dislocation
下载PDF
Are chaos and catastrophe theories relevant to environmental sciences?
15
作者 John Kaihong KAM 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 1992年第1期39-42,共4页
Data acquired in the area of Environmental Sciences are by their very nature often discontinuous and abrupt. As such, the mathematical theories of catastrophe and chaos may be of use in analyzing such scientific data ... Data acquired in the area of Environmental Sciences are by their very nature often discontinuous and abrupt. As such, the mathematical theories of catastrophe and chaos may be of use in analyzing such scientific data and in formulating mathematical models. 展开更多
关键词 CHAOS catastrophe environment.
下载PDF
Simulation of maize drought degree in Xi'an City based on cusp catastrophe model
16
作者 Hai-tao Chen Ji He +1 位作者 Wen-chuan Wang Xiao-nan Chen 《Water Science and Engineering》 EI CAS CSCD 2021年第1期28-35,共8页
Drought generally has significant impacts on crops.It is essential to quantitatively evaluate the relationship between crop production and drought degree to provide technical support for drought disaster prevention.In... Drought generally has significant impacts on crops.It is essential to quantitatively evaluate the relationship between crop production and drought degree to provide technical support for drought disaster prevention.In this study,a drought degree index that can reflect the changes in precipitation,evapotranspiration,and soil moisture was developed on the basis of crop yield reduction rate.Four drought scenarios were set up to simulate the effects of meteorological drought on drought degree of crops at different growth stages.A cusp catastrophe model was constructed to analyze the mutation characteristics of the drought degree of maize at different growth stages under different meteorological drought conditions.Xi'an City in China was selected as the study area,and summer maize was selected as the research crop.Precipitation and crop yield data from 1951 to 2010 were used as the fundamental data to investigate drought degree mutation of summer maize.The results show that,under the meteorological drought conditions at the emergence-jointing stage,drought degree may change abruptly,and soil moisture content at the sowingemergence,jointing-tasseling,and tasseling-mature stages should be kept higher than 39%. 展开更多
关键词 Cusp catastrophe Drought degree Crop growth period Soil moisture content MAIZE
下载PDF
Research on the Risk Associated with Rural Drinking Water Safety Based on Catastrophe Theory
17
作者 Chao Wang Fu-Quan Ni +1 位作者 Yu Deng Lin-Lin Jiang 《Journal of Water Resource and Protection》 2011年第6期356-362,共7页
In this study, based on the analysis of the catastrophic risk of rural drinking water, with the representative villages in Ya’an as study objects and setting the four evaluation standards: water quality, water quanti... In this study, based on the analysis of the catastrophic risk of rural drinking water, with the representative villages in Ya’an as study objects and setting the four evaluation standards: water quality, water quantity, the Guarantee Probability for water Supply and the Convenience Level of the Access to Water Supply as the ba- sic framework, a Rural Drinking Water Safety Assessment was developed (RDWSA). Research showed that Catastrophe Theory was applicable in the RDWSA. Adding RDWSA based on Catastrophe Theory to the supportive system for decision-making in Ecological Hydrographic Management Decision Support System of Ya’an helped obtain the rank and results of RDWSE by the automatic calculation of programs, which could assist the risk assessment and risk management associated with rural drinking water in Ya’an. 展开更多
关键词 catastrophe THEORY RISK RURAL DRINKING WATER Safety Ya’an
下载PDF
Comprehensive Disaster Risk Prevention of "the Belt and Road Initiative":Important Significance,Catastrophe Risk,International Cooperation and Strategic Countermeasure
18
作者 Feng KONG 《Asian Agricultural Research》 2019年第9期46-50,共5页
"The Belt and Road Initiative"is major decision proposed by the CPC Central Committee with comrade Xi Jinping as the core co-ordinating the domestic and international overall situations,and concerns peaceful... "The Belt and Road Initiative"is major decision proposed by the CPC Central Committee with comrade Xi Jinping as the core co-ordinating the domestic and international overall situations,and concerns peaceful rise of China and extension of the strategic opportunity period of modernization construction.It needs multi-faceted safeguards to successfully impel"the Belt and Road Initiative",in which disaster risk identification and its effective prevention and control are indispensable links.By integrating geogeographic and atmospheric environmental factors,countries along"the Belt and Road Initiative"belong to frequent occurrence region of major natural disasters.It restricts not only the economic and social development of relevant countries but also implementation effect of"the Belt and Road Initiative"construction,and is also related to the success or failure of Chinese enterprises going out to a certain extent.It should enhance disaster prevention and mitigation and ensure safety of major infrastructure construction related to interconnection of"the Belt and Road Initiative"by disaster identification and prevention,which is the key of successfully impelling strategy implementation and major need for guaranteeing the people s livelihood of the countries along the line.The work of disaster prevention and mitigation in the countries along the line is generally weak,and it is urgent to raise the level of disaster prevention as a whole by promoting the disaster prevention and mitigation cooperation in the"the Belt and Road Initiative"area;improve the coverage and level of disaster risk insurance;enhance construction in monitoring and early warning capability of natural disaster;strengthen structural adjustment of economy,industry and land use responding to climate change risks;establish a comprehensive disaster reduction forum of"the Belt and Road Initiative",and contain relevant content in"the Belt and Road Initiative"series of high-end forum topics. 展开更多
关键词 The BELT and ROAD INITIATIVE COMPREHENSIVE disaster PREVENTION and mitigation catastrophe risk Climate change National security and sustainable development
下载PDF
Agricultural Mechanism of Spreading Catastrophe Risk in China and Legislation Conception
19
作者 LI Xu-dong,SUN Yao-wei Law Department of Southwest University,Chongqing 400716,China 《Asian Agricultural Research》 2011年第4期18-23,29,共7页
This paper introduces agricultural catastrophe and its characteristics,and conducts comparative analysis on existing mechanism of spreading agricultural catastrophe risk,indicating that the mechanism of administrative... This paper introduces agricultural catastrophe and its characteristics,and conducts comparative analysis on existing mechanism of spreading agricultural catastrophe risk,indicating that the mechanism of administrative remedy has the greatest efficiency and highest cost;the mechanism of social assistance has the lowest cost,but its efficiency is lowest and there are unstable factors;market mechanism,namely the insurance of agricultural catastrophe,is the rational choice of agricultural department in mechanism of risk spreading.This paper analyzes the status quo of China's insurance of agricultural catastrophe,indicating that the main body of management in China's insurance of agricultural catastrophe is missing.In addition,the market demand is critically scanty,and insurance of agricultural catastrophe lacks external development environment.The gap of China's insurance law of agricultural catastrophe has become the greatest obstacle to the development of insurance of agricultural catastrophe.From legislative purpose,basic principle,nature,main body of legal relations,management range,policy support,supervision and management and so on,the legislation conception of China's insurance of agricultural catastrophe is put forward. 展开更多
关键词 AGRICULTURAL catastrophe SPREADING mechanism Agric
下载PDF
Fisher’(1967)Ambiguity Revised:A Catastrophe Theory’ Approach(I)
20
作者 David Catela Liliana Gens Cristiana Mercê 《Psychology Research》 2018年第11期572-575,共4页
Half of a century has passed on Fisher’ambiguity pictures(1967).To celebrate this occasion,we have analysed his data,using the polynomial function for a cusp catastrophe,and we have discussed the results under dynami... Half of a century has passed on Fisher’ambiguity pictures(1967).To celebrate this occasion,we have analysed his data,using the polynomial function for a cusp catastrophe,and we have discussed the results under dynamical systems theory’propositions. 展开更多
关键词 catastrophe potential LANDSCAPE VISUAL PERCEPTION
下载PDF
上一页 1 2 197 下一页 到第
使用帮助 返回顶部