Objective: to investigate the effect of minimally invasive technique in the clinical treatment of orthopedic trauma. Methods: the study subjects were selected from 80 orthopedic trauma patients admitted to our hospita...Objective: to investigate the effect of minimally invasive technique in the clinical treatment of orthopedic trauma. Methods: the study subjects were selected from 80 orthopedic trauma patients admitted to our hospital from December 2016 to December 2019, and were divided into control group and research group according to the order of admission. Clinical indexes and complications of the two groups were compared. Results: incision length, operative time, intraoperative blood loss, dressing change times and incision healing time in study group were all lower than those in control group (P < 0.05). The incidence of complications in study group was significantly lower than that in control group (P < 0.05). Conclusion: the application of minimally invasive technique in traumatic orthopedic clinical treatment, which can effectively shorten the patient surgery incision length, shorten the operation time and incision healing time, reduce intraoperative blood loss and the number of its form, can reduce the probability of to cause patients with complications, promote the recovery of the patient's body, improve the rate of good patient care.展开更多
Objective: this article mainly analyzes and studies the factors leading to hemorrhagic shock in obstetrics and gynecology and the clinical treatment measures. Methods: 120 patients with hemorrhagic shock were selected...Objective: this article mainly analyzes and studies the factors leading to hemorrhagic shock in obstetrics and gynecology and the clinical treatment measures. Methods: 120 patients with hemorrhagic shock were selected from the department of obstetrics and gynecology of the hospital. The patients were divided according to the symptoms of blood loss, and then the shock factors of the patients were judged according to the blood loss of different symptoms. Results: through the hospital rescue treatment, 114 out of 120 patients with hemorrhagic shock were successfully rescued. Among the 6 patients who failed rescue, 1 patient was partial hysterectomy, 3 patients were total hysterectomy, and 2 patients were ineffective in surgical rescue. On the whole, there are four factors leading to hemorrhagic shock, the first is uterine factor, the second is placenta factor, the third is reproductive tract factor, and the fourth is dysfunction factor. Conclusion: through the analysis and research in this paper, we can correctly understand the factors of patients with hemorrhagic shock in obstetrics and gynecology, and then take corresponding treatment measures according to these factors, so as to ensure the quality of patients shock rescue and the safety of patients.展开更多
Objective:This study aims to explore the value of comprehensive intervention in the clinical treatment of patients with type 2 diabetes mellitus complicated with hypertension.Methods:90 patients with type 2 diabetes a...Objective:This study aims to explore the value of comprehensive intervention in the clinical treatment of patients with type 2 diabetes mellitus complicated with hypertension.Methods:90 patients with type 2 diabetes and hypertension were selected and divided into a control group and an intervention group according to the random number table method,with 45 cases in each group.The control group received conventional treatment,and the intervention group received comprehensive intervention on the basis of the control group,including a diet plan,an exercise program,scientific treatment,regular monitoring,and psychological counseling.The blood sugar,blood pressure,and other indicators of the two groups were compared.Results:After 5 months of intervention,the fasting blood glucose,postprandial 2 h blood glucose,glycosylated blood glucose protein,diastolic blood pressure,systolic blood pressure,mean arterial pressure,and other indicators of the intervention group were significantly lower than the control group(P<0.05),and the rate of decrease was significantly greater than that of the control group(P<0.05).Conclusion:Comprehensive intervention for patients with type 2 diabetes mellitus and hypertension helps in controlling blood sugar and lowering blood pressure,with clinical significance.展开更多
Objective: to analyze the methods and curative effects of clinical treatment in emergency medicine for elderly patients with severe heart failure. Methods: a total of 48 elderly patients with severe heart failure who ...Objective: to analyze the methods and curative effects of clinical treatment in emergency medicine for elderly patients with severe heart failure. Methods: a total of 48 elderly patients with severe heart failure who were treated in our hospital within one year (February 2021 to February 2022) were randomly divided into control group and observation group. The control group was treated with conventional treatment measures, while the observation group was treated with comprehensive treatment measures of emergency medicine. The curative effects of the two groups were compared. Results: the total effective rate in the observation group was significantly higher than that in the control group. Conclusion: clinical treatment of emergency medicine can effectively improve the symptoms of elderly patients with severe heart failure, which is worth popularizing.展开更多
In recent years, with the deterioration of the global ecological environment and the change of people's lifestyle, allergic rhinitis (AR) has gradually become a common and frequently-occurring disease in otolaryng...In recent years, with the deterioration of the global ecological environment and the change of people's lifestyle, allergic rhinitis (AR) has gradually become a common and frequently-occurring disease in otolaryngology, and the risk of inducing asthma increases with the duration of rhinitis. According to some data, the incidence rate of AR is as high as 10%~25% in the world. The main clinical manifestations are nasal congestion, nasal itching, runny nose, sneezing and other nasal membrane inflammatory reactions, which affect the olfactory function, reduce the sleep quality and bring great inconvenience to people's daily life and work. It cannot be eradicated, so clinical treatment is usually focused on relieving acute symptoms, stabilizing the development of the disease and preventing relapse. In this paper, the common clinical treatments of AR are classified and analyzed.展开更多
Objective: in order to further strengthen the discussion and research on the practical nursing effect of minimally invasive techniques on orthopedic patients during the clinical treatment of traumatic orthopedics. Met...Objective: in order to further strengthen the discussion and research on the practical nursing effect of minimally invasive techniques on orthopedic patients during the clinical treatment of traumatic orthopedics. Methods: from February 2022 to July 2022 in our hospital, 118 orthopedic patients who received a series of treatment and nursing work were investigated and observed comprehensively. Fifty-nine cases of orthopedic treatment with conventional medical means were taken as the reference group, and 59 cases of orthopedic treatment with minimally invasive techniques were taken as the research group. By comprehensively recording and comparing the clinical symptoms (frequency of dressing change, recovery time of wound site, hospitalization time, length of wound site, total operation time, actual blood loss during operation), clinical actual curative effect, adverse performance related data (infection of wound site, poor recovery, reddish swelling) of 118 patients undergoing orthopedic treatment. Results: the clinical symptoms and bad performance data of 59 patients in the research group treated by minimally invasive technique were lower than those of 59 patients in the reference group treated by conventional therapy, while the clinical actual curative effect was much higher than that of 59 patients in the reference group treated by conventional therapy. Conclusion: minimally invasive technique can effectively reduce the clinical symptoms and data related to adverse performance, and greatly improve the clinical curative effect of patients, which is worthy of large-scale clinical application.展开更多
Objective: to investigate the clinical effect of relapsed refractory acute myeloid leukemia. Methods: 160 patients with relapsed refractory acute myeloid leukemia in our hospital from January 2019 to January 2021 were...Objective: to investigate the clinical effect of relapsed refractory acute myeloid leukemia. Methods: 160 patients with relapsed refractory acute myeloid leukemia in our hospital from January 2019 to January 2021 were randomly divided into the observation group and the control group. 80 patients in the control group were treated with CAG treatment scheme, and 80 patients in the observation group were treated with decitabine on the basis of CAG treatment scheme. The final treatment effect of the two groups of patients was compared. Results: the therapeutic effect of the observation group was better than that of the control group. In contrast, the effective rate of 82.50% in the observation group was higher than that of 67.50% in the other group;There was no difference in the incidence of adverse reactions between the two groups. Conclusion: CAG combined with decitabine is effective in the treatment of relapsed refractory acute myeloid leukemia. The quality of life of the patients can be effectively improved. Compared with the previous patients, they have a higher degree of life comfort. The disease control effect of the patients is better, and the adverse reactions are also within the controllable range.展开更多
Objective: to think about the clinical treatment plan of diabetes patients with hypertension, and to sort out its treatment principle and application mechanism. Methods: a retrospective study was conducted to sort out...Objective: to think about the clinical treatment plan of diabetes patients with hypertension, and to sort out its treatment principle and application mechanism. Methods: a retrospective study was conducted to sort out 30 patients with diabetes mellitus and hypertension who were admitted to our hospital from January 2021 to January 2022. Health guidance was given to the patients, then the daily salt intake of the patients was strictly controlled, and the biochemical, cardiac color Doppler ultrasound, electrocardiogram, chest X-ray, fundus, blood routine, urine routine and other indicators of the patients were strengthened, and then the related examination results were comprehensively sorted out. Among them, diabetic patients also need to take appropriate oral hypoglycemic drugs in combination with the change of blood sugar, among which 13 patients choose to be treated by injecting insulin drugs. If the blood pressure of the patient is not less than 140/90mmHg, the patient should be instructed to use antihypertensive drugs according to the specific condition of the patient. Results: for all patients, after receiving the clinical treatment, most of the clinical treatment effects are very obvious, only 3 patients have varying degrees of hypoglycemia and other changes during the medication period, 2 patients' early renal diseases have been significantly improved and alleviated through standardized treatment, and 1 patient has received timely and standardized treatment after cerebral hemorrhage. Conclusion: according to the specific conditions of patients, it is necessary to study the disease characteristics and principles of patients and urge patients to receive standardized treatment as soon as possible in order to obtain ideal therapeutic effect.展开更多
Extensive efforts have been put into reducing the heavy burden of esophageal squamous cell carcinoma(ESCC)in China.However,the joint impact of prevention and treatment on the long-term overall survival(OS)of ESCC pati...Extensive efforts have been put into reducing the heavy burden of esophageal squamous cell carcinoma(ESCC)in China.However,the joint impact of prevention and treatment on the long-term overall survival(OS)of ESCC patients remains largely unknown.We consecutively recruited 13,255 ESCC patients from two Chinese centers:the Northern center,located in a high-risk area with abundant screening programs;and the Southern center,situated in a non-high-risk area with improved clinical practices.Inter-center comparison,longitudinal intra-center comparison,and a simulation analysis were conducted to investi-gate the influence of tumor downstaging and high-quality clinical treatment on OS.During a follow-up period of 12.52 years,the Northern center exhibited higher median survival than the Southern center(6.22 vs.3.15 years;H_(Radjusted)=0.73,95%CI:0.69-0.77).Mediation analysis demonstrated that its OS advantage was largely(77.7%)attributed to earlier TNM stage(stage 0-II:51.3%vs.24.6%).In temporal analyses,patient survival in the Southern center gradually improved(median survival during 2015-2018 vs.2009-2014:3.58 vs.2.93 years;H_(Radjusted)=0.86,95%CI:0.79-0.94),coinciding with the progress of treatment-related indices(completeness of TNM staging in discharge diagnosis[from 53.7%to 99.6%],adoption of minimally invasive esophagectomy[from 0.0%to 51.1%]and right thoracic esophagectomy[from 12.4%to 86.4%],etc.).Simulation analysis further demonstrated that integrating both downstaging and high-quality treatment would lead to the best survival.Tumor downstaging and high-quality clinical treatment have a joint impact on ESCC patient survival.Establishing a comprehensive strategy that inte-grates cancer prevention with optimal clinical treatment is crucial for alleviating the ESCC burden.展开更多
Objective: To explore the clinical effectiveness and safety of trastuzumab combined with chemotherapy in breast cancer patients. Methods: Eighty patients with postoperative local recurrence of breast cancer were divid...Objective: To explore the clinical effectiveness and safety of trastuzumab combined with chemotherapy in breast cancer patients. Methods: Eighty patients with postoperative local recurrence of breast cancer were divided into a control group (chemotherapy only) and an observation group (chemotherapy plus trastuzumab-targeted therapy). The clinical efficacy, adverse reactions, and complications were compared between groups. Results: The overall effective rate of clinical treatment in the observation group was higher than that in the control group (P < 0.05). The incidence of adverse reactions showed no difference between the groups (P > 0.05), while the complication rate was significantly lower in the observation group (P < 0.05). Conclusion: Trastuzumab-targeted therapy combined with chemotherapy can significantly improve clinical treatment outcomes for breast cancer patients, reduce the risk of complications, and maintain good safety, making it suitable for clinical promotion.展开更多
Disorders in energy homeostasis can lead to various metabolic diseases,particularly obesity.The obesity epidemic has led to an increased incidence of obesityrelated nephropathy(ORN),a distinct entity characterized by ...Disorders in energy homeostasis can lead to various metabolic diseases,particularly obesity.The obesity epidemic has led to an increased incidence of obesityrelated nephropathy(ORN),a distinct entity characterized by proteinuria,glomerulomegaly,progressive glomerulosclerosis,and renal function decline.Obesity and its associated renal damage are common in clinical practice,and their incidence is increasing and attracting great attention.There is a great need to identify safe and effective therapeutic modalities,and therapeutics using chemical compounds and natural products are receiving increasing attention.However,the summary is lacking about the specific effects and mechanisms of action of compounds in the treatment of ORN.In this review,we summarize the important clinical features and compound treatment strategies for obesity and obesityinduced kidney injury.We also summarize the pathologic and clinical features of ORN as well as its pathogenesis and potential therapeutics targeting renal inflammation,oxidative stress,insulin resistance,fibrosis,kidney lipid accumulation,and dysregulated autophagy.In addition,detailed information on natural and synthetic compounds used for the treatment of obesity-related kidney disease is summarized.The synthesis of detailed information aims to contribute to a deeper understanding of the clinical treatment modalities for obesity-related kidney diseases,fostering the anticipation of novel insights in this domain.展开更多
Objective: to explore the effect of shenghua Decoction combined with misoprostol in the application of delayed abortion, and explore its application value. Methods: a total of 68 parturients admitted to the Department...Objective: to explore the effect of shenghua Decoction combined with misoprostol in the application of delayed abortion, and explore its application value. Methods: a total of 68 parturients admitted to the Department of Obstetrics and Gynecology of Nanjing Hospital of Integrated Traditional Chinese and Western Medicine from April 2019 to April 2020 were selected as clinical observation objects. A randomized controlled trial was conducted in this study, and 68 parturients were randomly arranged and divided into control group and experimental group, with 34 patients in each group. In the control group patients receiving treatment in choosing misoprostol treatment, treatment group patients were based on the application of biochemical treatment, tang in the treatment of after, to record the curative effect of two groups of patients, and records of patients with pregnancy sac discharge time and bleeding time, record in the process of treatment in patients with blood loss, to record the final result. Results: after treatment, the total effective rate of experimental group was 91.18%, which was higher than 79.41% of control group (P < 0.05). The results of this study showed that compared with the control group, the average amount of maternal bleeding in the experimental group was less than that in the control group, and the time of vaginal bleeding and pregnancy sac excretion was significantly shorter in the patients, and the data were statistically significant (P < 0.05). Conclusion: the incidence of missed abortion in clinical is higher, and in the treatment of patients, select biochemical treatment tonga taste combined misoprostol is helpful to improve the effect of the treatment of patients with, and shorten the time of vaginal bleeding patients and reduce the bleeding, has good clinical value, worthy of further promotion.展开更多
In order to do a good job in the treatment of rheumatoid arthritis, the article mainly analyzes the clinical therapeutic effect of Tibetan medicine bath Kaca. The article mainly investigates 152 patients in our hospit...In order to do a good job in the treatment of rheumatoid arthritis, the article mainly analyzes the clinical therapeutic effect of Tibetan medicine bath Kaca. The article mainly investigates 152 patients in our hospital, applies Tibetan medicine bath card to wipe external therapy, prepares corresponding Tibetan medicine for patients in advance, and combines various methods of fusion therapy such as physical therapy. After a period of investigation, the number of patients with marked effect, effective and ineffective treatment was 72, 64 and 16 respectively, and the overall effective rate was 89.47%. It can be seen from this that the Tibetan medicine bath Kaca method has a good therapeutic effect for patients with rheumatoid arthritis, and is worthy of all-round promotion and application by industry personnel for a long period of time now and even in the future.展开更多
Objective: To study the treatment of B-Thalas-semia (ThE) with Chinese herbal medicine for Bushen Yisui (BSYS), its theoretical base and molecular mechanism. Methods: Seventy-eight patients with ThE were treated with ...Objective: To study the treatment of B-Thalas-semia (ThE) with Chinese herbal medicine for Bushen Yisui (BSYS), its theoretical base and molecular mechanism. Methods: Seventy-eight patients with ThE were treated with BSYS recipe (consisted of 11 Chinese herbal drugs as Dogwood fruit, Fleeceflower root, prepared Rehmannia root and turtle shell, etc.) orally taken, 3 times per day, 10 g/time, 3 months as one therapeutic course. Hemoglobin (Hb), red blood cell (RBC), reticulocyte (Ret) and hemoglobin F (HbF) were checked every month. At the same time, PAGE, PVR, PCR-SSCP, RT-PCR, DNA series analysis, mRNA gene expression analysis techniques were used to conduct the systematic gene analysis in patients to study the molecular mechanism of TCM treatment from aspects of gene mutation, gene expression and control-regulation. Results: All the blood criteria in patients after BSYS treatment were improved significantly with clinical symptoms展开更多
The clinical value of transvaginal ultrasound in clinical surgical treatment of cesarean scar pregnancy（CSP） was evaluated. The clinical data of 104 patients with CSP admitted at Tongji Hospital from 2013 to 2016 we...The clinical value of transvaginal ultrasound in clinical surgical treatment of cesarean scar pregnancy（CSP） was evaluated. The clinical data of 104 patients with CSP admitted at Tongji Hospital from 2013 to 2016 were collected and analyzed retrospectively, including the patients＇ age, gestational age, the size of gestational sac or uneven mass, the uterine scar thickness, β human chorionic gonadotropin（h CG） levels and so on. Of these 104 cases, 30 cases were subjected to laparotomy, 29 cases to laparoscopy, 27 cases to hysteroscopy, 16 cases to ultrasound-guided uterine curettage, and 2 cases to conservative treatment. The transvaginal ultrasound showed that uterine scar thickness and gestational sac or uneven mass size had significant difference（P〈0.05） among different surgical methods by comparatively analyzing the patients＇ data. It was suggested that transvaginal ultrasound may provide the valuable reference for choosing clinical surgical procedures for CSP.展开更多
From January 2001 to January 2002, 50 patients of candidal vaginitis were treated by Kushen powder (KSP,苦参散) combined with Canesten as the treatment group, and controlled by a control group including another 50 pat...From January 2001 to January 2002, 50 patients of candidal vaginitis were treated by Kushen powder (KSP,苦参散) combined with Canesten as the treatment group, and controlled by a control group including another 50 patients treated with Canesten alone. The therapeutic results were satisfactory and reported as follows.展开更多
Objective: To explore the therapeutic mechanism of Tiaoxin Recipe and Bushen Recipe (BSR, ) in treating Alzheimer’s d isease (AD). Methods: Sixty patients with AD were divided into 3 groups according to their MMSE an...Objective: To explore the therapeutic mechanism of Tiaoxin Recipe and Bushen Recipe (BSR, ) in treating Alzheimer’s d isease (AD). Methods: Sixty patients with AD were divided into 3 groups according to their MMSE and ADL scores before treatment, using randomized block design. They were treated separately with TXR, BSR and Donepezil (Dp) for 12 weeks. The changes of MMSE score, ADL score, neuro-psychology amount table score, including FOM, RVR, DS and BD, as well as the overall operational evaluation before and after treatment were analyzed. Results: The recognition and daily life capacity of patients in the 3 groups were improved after treatment. MMSE score in the TXR group increased from 16.10±1.94 scores before treatment to 17 90±2 59 scores after treatment, in the BSR group, from 16 15±2 16 to 17 50±2 59, and in the Dp group, from 17 35±1 90 to 19 60±3 39, all showed significant difference (all P<0 01). Change of ADL score showed that in the TXR group, it lowere d from 43 10±3 86 to 41 50±4 40, in the BSR group from 43 30±4 53 to 41 60±4 12 and in the Dp group, from 42 95±3 58 to 40 60±5 23, which also showed significan t difference (P<0 05 or P<0 01). Moreover, increase of FOM, RVR and DS score was shown in the TXR and the Dp group, and increase of RVR and BD score was shown in the BSR group, with significant difference in compar ison of corresponding score before and after treatment, inter-groups comparison showed significant difference of FOM score between the BSR and the Dp group ( P<0 01). Overall operational evaluation (total effective rate) in the TXR group was 70%, in the BSR group 65% and in Dp group 75%, with no significant difference among them. Conclusion: TXR and BSR are effective TCM drugs in treating AD展开更多
Objective:To investigate the relationship between clinical manifestations,blood testing,chest CT,treatment and fever of 457mild cases of COVID-19.Methods:A tatal of 457cases of mild COVID-19 diagnosed in Wuhan Jiangha...Objective:To investigate the relationship between clinical manifestations,blood testing,chest CT,treatment and fever of 457mild cases of COVID-19.Methods:A tatal of 457cases of mild COVID-19 diagnosed in Wuhan Jianghan module Hospital from February 6,2020 to February 26,2020 were gathered,and the cases with/without fever were retrospectively analyzed in epidemiology,clinical manifestation,blood routing,hypersensitive C-reactive protein(hs-CRP),pathogens serological testing,chest CT and drugs treatment.Results:For 312 fever cases,the average age was(47.6±10.9)years old,male was 128 cases(41%),the mean peak fever was 38(36.8,38.6)℃,fever lasting was 2(0,3)days,131cases(28.7%)had Huanan seafood market exposure history,90 cases(28.8%)had closely contact with COVID-19 patients,20cases(6.4%)had hypertension history,10 cases(3.2%)had diabetes,5cases(1.6%)had coronary heart disease.Main symptoms of fever group including dry cough of 260cases(83.3%),of 104cases(33.3%),blood sputum of 9cases(2.9%),chest tightness 20cases(19.6%),shortness of breath of 87cases(27.9%),weak of 105cases(33.7%),diarrhea of 43cases(13.8%),sleep disorders of 61cases(19.6%),among fever cases with sputum and shortness of breath more rather without fever,and two groups were statistically significantly difference(P<0.05).In fever group,WBC(109/L)[4.34(3.69,5.26)than 5.11(4.22,6.22),P<0.001],NEUT(109/L)[2.67(2.1,3.49)than 2.88(2.37,3.9),P<0.05],LYM(109/L)[0.9(0.8,1.1)than 1.36(1.03,1.85),P<0.001),PLT(109/L)/(106,188)134-189(132,224),P<0.001)were lower than normal group,while WBC<4.0×109/L[108(34.6%)than 24(16.6%),P<0.001)],LYM<1.0×109/L[189(60.6%)than 31(21.4%),P<0.001)],PLT<100×109/L[45(14.4%)than in 2(1.4%),P<0.001)and hs-CRP(mg/L)[14(6.83,32)than 3.4(0.96,10.75),P<0.001)were higher than normal group,and pathogens serological examination of 36cases shown influenzaⅠ/Ⅱvirus IgM antibody positive in 3cases(8.3%),respiratory syncytial virus IgM antibody positive in 2 cases(5.6%),mycoplasma pneumoniae IgM antibody positive(11.1%),4 cases of adenovirus IgM antibody positive(11.1%),but 4 pathogens of fever group and normal group were no statistical difference(P>0.05).According to early onset of chest CT examination,there were no change of 11cases(2.4%),unilateral lung lesions of 93cases(20.4%),bilateral lung lesions of 353 cases(77.2%),ground glass shadow of 228 cases(73.1%),high density shadow patch of 65 cases(20.8%),consolidation shadow of 6 cases(1.9%),while fever group compared with normal group,there were no statistically significant difference(P>0.05).Logistic regression analysis showed that LYM(OR=0.24,95%CI=0.139~0.415,P<0.001),LYM<1.0 x 109/L(OR=5.12,95%CI=3.07~8.65,P<0.001),PLT<100×109/L(OR=6.1,95%CI=1.36~27.33,P<0.05),and the hs-CRP(OR=1.03,95%CI=1.02~1.05,P<0.001)were fever independent impact factors in mild COVID-19.Aiming at COVID-19 treatment,Chinese medicine usage had 416cases(91%),antiviral drugs had 328cases(71.8%),and antibiotics had 172cases(37.6%),furthermore,fever group using antiviral and antibiotic drugs was higher than normal group(P<0.05),and compared to low fever group,high fever group used more antibiotic drugs(P<0.05).Conclusions:Mild COVID-19 patients with early onset had epidemiological characteristics,and fever,dry cough,expectoration and shortness of breath were main symptoms,and chest CT often involved bilateral lung lesions,ground glass shadow and patch density shadow.The fever patients in WBC,LYM,PLT,hs-CRP index changed significantly and could affect on anti-infective therapy selection.展开更多
文摘Objective: to investigate the effect of minimally invasive technique in the clinical treatment of orthopedic trauma. Methods: the study subjects were selected from 80 orthopedic trauma patients admitted to our hospital from December 2016 to December 2019, and were divided into control group and research group according to the order of admission. Clinical indexes and complications of the two groups were compared. Results: incision length, operative time, intraoperative blood loss, dressing change times and incision healing time in study group were all lower than those in control group (P < 0.05). The incidence of complications in study group was significantly lower than that in control group (P < 0.05). Conclusion: the application of minimally invasive technique in traumatic orthopedic clinical treatment, which can effectively shorten the patient surgery incision length, shorten the operation time and incision healing time, reduce intraoperative blood loss and the number of its form, can reduce the probability of to cause patients with complications, promote the recovery of the patient's body, improve the rate of good patient care.
文摘Objective: this article mainly analyzes and studies the factors leading to hemorrhagic shock in obstetrics and gynecology and the clinical treatment measures. Methods: 120 patients with hemorrhagic shock were selected from the department of obstetrics and gynecology of the hospital. The patients were divided according to the symptoms of blood loss, and then the shock factors of the patients were judged according to the blood loss of different symptoms. Results: through the hospital rescue treatment, 114 out of 120 patients with hemorrhagic shock were successfully rescued. Among the 6 patients who failed rescue, 1 patient was partial hysterectomy, 3 patients were total hysterectomy, and 2 patients were ineffective in surgical rescue. On the whole, there are four factors leading to hemorrhagic shock, the first is uterine factor, the second is placenta factor, the third is reproductive tract factor, and the fourth is dysfunction factor. Conclusion: through the analysis and research in this paper, we can correctly understand the factors of patients with hemorrhagic shock in obstetrics and gynecology, and then take corresponding treatment measures according to these factors, so as to ensure the quality of patients shock rescue and the safety of patients.
文摘Objective:This study aims to explore the value of comprehensive intervention in the clinical treatment of patients with type 2 diabetes mellitus complicated with hypertension.Methods:90 patients with type 2 diabetes and hypertension were selected and divided into a control group and an intervention group according to the random number table method,with 45 cases in each group.The control group received conventional treatment,and the intervention group received comprehensive intervention on the basis of the control group,including a diet plan,an exercise program,scientific treatment,regular monitoring,and psychological counseling.The blood sugar,blood pressure,and other indicators of the two groups were compared.Results:After 5 months of intervention,the fasting blood glucose,postprandial 2 h blood glucose,glycosylated blood glucose protein,diastolic blood pressure,systolic blood pressure,mean arterial pressure,and other indicators of the intervention group were significantly lower than the control group(P<0.05),and the rate of decrease was significantly greater than that of the control group(P<0.05).Conclusion:Comprehensive intervention for patients with type 2 diabetes mellitus and hypertension helps in controlling blood sugar and lowering blood pressure,with clinical significance.
文摘Objective: to analyze the methods and curative effects of clinical treatment in emergency medicine for elderly patients with severe heart failure. Methods: a total of 48 elderly patients with severe heart failure who were treated in our hospital within one year (February 2021 to February 2022) were randomly divided into control group and observation group. The control group was treated with conventional treatment measures, while the observation group was treated with comprehensive treatment measures of emergency medicine. The curative effects of the two groups were compared. Results: the total effective rate in the observation group was significantly higher than that in the control group. Conclusion: clinical treatment of emergency medicine can effectively improve the symptoms of elderly patients with severe heart failure, which is worth popularizing.
文摘In recent years, with the deterioration of the global ecological environment and the change of people's lifestyle, allergic rhinitis (AR) has gradually become a common and frequently-occurring disease in otolaryngology, and the risk of inducing asthma increases with the duration of rhinitis. According to some data, the incidence rate of AR is as high as 10%~25% in the world. The main clinical manifestations are nasal congestion, nasal itching, runny nose, sneezing and other nasal membrane inflammatory reactions, which affect the olfactory function, reduce the sleep quality and bring great inconvenience to people's daily life and work. It cannot be eradicated, so clinical treatment is usually focused on relieving acute symptoms, stabilizing the development of the disease and preventing relapse. In this paper, the common clinical treatments of AR are classified and analyzed.
文摘Objective: in order to further strengthen the discussion and research on the practical nursing effect of minimally invasive techniques on orthopedic patients during the clinical treatment of traumatic orthopedics. Methods: from February 2022 to July 2022 in our hospital, 118 orthopedic patients who received a series of treatment and nursing work were investigated and observed comprehensively. Fifty-nine cases of orthopedic treatment with conventional medical means were taken as the reference group, and 59 cases of orthopedic treatment with minimally invasive techniques were taken as the research group. By comprehensively recording and comparing the clinical symptoms (frequency of dressing change, recovery time of wound site, hospitalization time, length of wound site, total operation time, actual blood loss during operation), clinical actual curative effect, adverse performance related data (infection of wound site, poor recovery, reddish swelling) of 118 patients undergoing orthopedic treatment. Results: the clinical symptoms and bad performance data of 59 patients in the research group treated by minimally invasive technique were lower than those of 59 patients in the reference group treated by conventional therapy, while the clinical actual curative effect was much higher than that of 59 patients in the reference group treated by conventional therapy. Conclusion: minimally invasive technique can effectively reduce the clinical symptoms and data related to adverse performance, and greatly improve the clinical curative effect of patients, which is worthy of large-scale clinical application.
文摘Objective: to investigate the clinical effect of relapsed refractory acute myeloid leukemia. Methods: 160 patients with relapsed refractory acute myeloid leukemia in our hospital from January 2019 to January 2021 were randomly divided into the observation group and the control group. 80 patients in the control group were treated with CAG treatment scheme, and 80 patients in the observation group were treated with decitabine on the basis of CAG treatment scheme. The final treatment effect of the two groups of patients was compared. Results: the therapeutic effect of the observation group was better than that of the control group. In contrast, the effective rate of 82.50% in the observation group was higher than that of 67.50% in the other group;There was no difference in the incidence of adverse reactions between the two groups. Conclusion: CAG combined with decitabine is effective in the treatment of relapsed refractory acute myeloid leukemia. The quality of life of the patients can be effectively improved. Compared with the previous patients, they have a higher degree of life comfort. The disease control effect of the patients is better, and the adverse reactions are also within the controllable range.
文摘Objective: to think about the clinical treatment plan of diabetes patients with hypertension, and to sort out its treatment principle and application mechanism. Methods: a retrospective study was conducted to sort out 30 patients with diabetes mellitus and hypertension who were admitted to our hospital from January 2021 to January 2022. Health guidance was given to the patients, then the daily salt intake of the patients was strictly controlled, and the biochemical, cardiac color Doppler ultrasound, electrocardiogram, chest X-ray, fundus, blood routine, urine routine and other indicators of the patients were strengthened, and then the related examination results were comprehensively sorted out. Among them, diabetic patients also need to take appropriate oral hypoglycemic drugs in combination with the change of blood sugar, among which 13 patients choose to be treated by injecting insulin drugs. If the blood pressure of the patient is not less than 140/90mmHg, the patient should be instructed to use antihypertensive drugs according to the specific condition of the patient. Results: for all patients, after receiving the clinical treatment, most of the clinical treatment effects are very obvious, only 3 patients have varying degrees of hypoglycemia and other changes during the medication period, 2 patients' early renal diseases have been significantly improved and alleviated through standardized treatment, and 1 patient has received timely and standardized treatment after cerebral hemorrhage. Conclusion: according to the specific conditions of patients, it is necessary to study the disease characteristics and principles of patients and urge patients to receive standardized treatment as soon as possible in order to obtain ideal therapeutic effect.
基金supported by the National Key R&D Program of China(2021YFC2500405)the Natural Science Foundation of Beijing Municipality(7182033).
文摘Extensive efforts have been put into reducing the heavy burden of esophageal squamous cell carcinoma(ESCC)in China.However,the joint impact of prevention and treatment on the long-term overall survival(OS)of ESCC patients remains largely unknown.We consecutively recruited 13,255 ESCC patients from two Chinese centers:the Northern center,located in a high-risk area with abundant screening programs;and the Southern center,situated in a non-high-risk area with improved clinical practices.Inter-center comparison,longitudinal intra-center comparison,and a simulation analysis were conducted to investi-gate the influence of tumor downstaging and high-quality clinical treatment on OS.During a follow-up period of 12.52 years,the Northern center exhibited higher median survival than the Southern center(6.22 vs.3.15 years;H_(Radjusted)=0.73,95%CI:0.69-0.77).Mediation analysis demonstrated that its OS advantage was largely(77.7%)attributed to earlier TNM stage(stage 0-II:51.3%vs.24.6%).In temporal analyses,patient survival in the Southern center gradually improved(median survival during 2015-2018 vs.2009-2014:3.58 vs.2.93 years;H_(Radjusted)=0.86,95%CI:0.79-0.94),coinciding with the progress of treatment-related indices(completeness of TNM staging in discharge diagnosis[from 53.7%to 99.6%],adoption of minimally invasive esophagectomy[from 0.0%to 51.1%]and right thoracic esophagectomy[from 12.4%to 86.4%],etc.).Simulation analysis further demonstrated that integrating both downstaging and high-quality treatment would lead to the best survival.Tumor downstaging and high-quality clinical treatment have a joint impact on ESCC patient survival.Establishing a comprehensive strategy that inte-grates cancer prevention with optimal clinical treatment is crucial for alleviating the ESCC burden.
基金Yunnan Provincial Department of Education Scientific Research Fund Project“Research on the Construction of Antibody-Drug Conjugate MMAF-Trastuzumab and Its Biological Function in Inhibiting Breast Cancer”(Project No.2024J0227)。
文摘Objective: To explore the clinical effectiveness and safety of trastuzumab combined with chemotherapy in breast cancer patients. Methods: Eighty patients with postoperative local recurrence of breast cancer were divided into a control group (chemotherapy only) and an observation group (chemotherapy plus trastuzumab-targeted therapy). The clinical efficacy, adverse reactions, and complications were compared between groups. Results: The overall effective rate of clinical treatment in the observation group was higher than that in the control group (P < 0.05). The incidence of adverse reactions showed no difference between the groups (P > 0.05), while the complication rate was significantly lower in the observation group (P < 0.05). Conclusion: Trastuzumab-targeted therapy combined with chemotherapy can significantly improve clinical treatment outcomes for breast cancer patients, reduce the risk of complications, and maintain good safety, making it suitable for clinical promotion.
基金Supported by the National Natural Science Foundation of China,No.82100866(to Mao TH).
文摘Disorders in energy homeostasis can lead to various metabolic diseases,particularly obesity.The obesity epidemic has led to an increased incidence of obesityrelated nephropathy(ORN),a distinct entity characterized by proteinuria,glomerulomegaly,progressive glomerulosclerosis,and renal function decline.Obesity and its associated renal damage are common in clinical practice,and their incidence is increasing and attracting great attention.There is a great need to identify safe and effective therapeutic modalities,and therapeutics using chemical compounds and natural products are receiving increasing attention.However,the summary is lacking about the specific effects and mechanisms of action of compounds in the treatment of ORN.In this review,we summarize the important clinical features and compound treatment strategies for obesity and obesityinduced kidney injury.We also summarize the pathologic and clinical features of ORN as well as its pathogenesis and potential therapeutics targeting renal inflammation,oxidative stress,insulin resistance,fibrosis,kidney lipid accumulation,and dysregulated autophagy.In addition,detailed information on natural and synthetic compounds used for the treatment of obesity-related kidney disease is summarized.The synthesis of detailed information aims to contribute to a deeper understanding of the clinical treatment modalities for obesity-related kidney diseases,fostering the anticipation of novel insights in this domain.
文摘Objective: to explore the effect of shenghua Decoction combined with misoprostol in the application of delayed abortion, and explore its application value. Methods: a total of 68 parturients admitted to the Department of Obstetrics and Gynecology of Nanjing Hospital of Integrated Traditional Chinese and Western Medicine from April 2019 to April 2020 were selected as clinical observation objects. A randomized controlled trial was conducted in this study, and 68 parturients were randomly arranged and divided into control group and experimental group, with 34 patients in each group. In the control group patients receiving treatment in choosing misoprostol treatment, treatment group patients were based on the application of biochemical treatment, tang in the treatment of after, to record the curative effect of two groups of patients, and records of patients with pregnancy sac discharge time and bleeding time, record in the process of treatment in patients with blood loss, to record the final result. Results: after treatment, the total effective rate of experimental group was 91.18%, which was higher than 79.41% of control group (P < 0.05). The results of this study showed that compared with the control group, the average amount of maternal bleeding in the experimental group was less than that in the control group, and the time of vaginal bleeding and pregnancy sac excretion was significantly shorter in the patients, and the data were statistically significant (P < 0.05). Conclusion: the incidence of missed abortion in clinical is higher, and in the treatment of patients, select biochemical treatment tonga taste combined misoprostol is helpful to improve the effect of the treatment of patients with, and shorten the time of vaginal bleeding patients and reduce the bleeding, has good clinical value, worthy of further promotion.
文摘In order to do a good job in the treatment of rheumatoid arthritis, the article mainly analyzes the clinical therapeutic effect of Tibetan medicine bath Kaca. The article mainly investigates 152 patients in our hospital, applies Tibetan medicine bath card to wipe external therapy, prepares corresponding Tibetan medicine for patients in advance, and combines various methods of fusion therapy such as physical therapy. After a period of investigation, the number of patients with marked effect, effective and ineffective treatment was 72, 64 and 16 respectively, and the overall effective rate was 89.47%. It can be seen from this that the Tibetan medicine bath Kaca method has a good therapeutic effect for patients with rheumatoid arthritis, and is worthy of all-round promotion and application by industry personnel for a long period of time now and even in the future.
基金Supported by the key project of the 8th Five Year Plan of Scientific Committee of Guizhou Province(1993 No.2037)the key project of the"9th Five Year Plan”of Scientific Committee of Guizhou Province.(1996 No.1028)
文摘Objective: To study the treatment of B-Thalas-semia (ThE) with Chinese herbal medicine for Bushen Yisui (BSYS), its theoretical base and molecular mechanism. Methods: Seventy-eight patients with ThE were treated with BSYS recipe (consisted of 11 Chinese herbal drugs as Dogwood fruit, Fleeceflower root, prepared Rehmannia root and turtle shell, etc.) orally taken, 3 times per day, 10 g/time, 3 months as one therapeutic course. Hemoglobin (Hb), red blood cell (RBC), reticulocyte (Ret) and hemoglobin F (HbF) were checked every month. At the same time, PAGE, PVR, PCR-SSCP, RT-PCR, DNA series analysis, mRNA gene expression analysis techniques were used to conduct the systematic gene analysis in patients to study the molecular mechanism of TCM treatment from aspects of gene mutation, gene expression and control-regulation. Results: All the blood criteria in patients after BSYS treatment were improved significantly with clinical symptoms
基金supported by Central University Independent Innovation Fund of China(No.2015ZHYX009)
文摘The clinical value of transvaginal ultrasound in clinical surgical treatment of cesarean scar pregnancy（CSP） was evaluated. The clinical data of 104 patients with CSP admitted at Tongji Hospital from 2013 to 2016 were collected and analyzed retrospectively, including the patients＇ age, gestational age, the size of gestational sac or uneven mass, the uterine scar thickness, β human chorionic gonadotropin（h CG） levels and so on. Of these 104 cases, 30 cases were subjected to laparotomy, 29 cases to laparoscopy, 27 cases to hysteroscopy, 16 cases to ultrasound-guided uterine curettage, and 2 cases to conservative treatment. The transvaginal ultrasound showed that uterine scar thickness and gestational sac or uneven mass size had significant difference（P〈0.05） among different surgical methods by comparatively analyzing the patients＇ data. It was suggested that transvaginal ultrasound may provide the valuable reference for choosing clinical surgical procedures for CSP.
文摘From January 2001 to January 2002, 50 patients of candidal vaginitis were treated by Kushen powder (KSP,苦参散) combined with Canesten as the treatment group, and controlled by a control group including another 50 patients treated with Canesten alone. The therapeutic results were satisfactory and reported as follows.
文摘Objective: To explore the therapeutic mechanism of Tiaoxin Recipe and Bushen Recipe (BSR, ) in treating Alzheimer’s d isease (AD). Methods: Sixty patients with AD were divided into 3 groups according to their MMSE and ADL scores before treatment, using randomized block design. They were treated separately with TXR, BSR and Donepezil (Dp) for 12 weeks. The changes of MMSE score, ADL score, neuro-psychology amount table score, including FOM, RVR, DS and BD, as well as the overall operational evaluation before and after treatment were analyzed. Results: The recognition and daily life capacity of patients in the 3 groups were improved after treatment. MMSE score in the TXR group increased from 16.10±1.94 scores before treatment to 17 90±2 59 scores after treatment, in the BSR group, from 16 15±2 16 to 17 50±2 59, and in the Dp group, from 17 35±1 90 to 19 60±3 39, all showed significant difference (all P<0 01). Change of ADL score showed that in the TXR group, it lowere d from 43 10±3 86 to 41 50±4 40, in the BSR group from 43 30±4 53 to 41 60±4 12 and in the Dp group, from 42 95±3 58 to 40 60±5 23, which also showed significan t difference (P<0 05 or P<0 01). Moreover, increase of FOM, RVR and DS score was shown in the TXR and the Dp group, and increase of RVR and BD score was shown in the BSR group, with significant difference in compar ison of corresponding score before and after treatment, inter-groups comparison showed significant difference of FOM score between the BSR and the Dp group ( P<0 01). Overall operational evaluation (total effective rate) in the TXR group was 70%, in the BSR group 65% and in Dp group 75%, with no significant difference among them. Conclusion: TXR and BSR are effective TCM drugs in treating AD
文摘Objective:To investigate the relationship between clinical manifestations,blood testing,chest CT,treatment and fever of 457mild cases of COVID-19.Methods:A tatal of 457cases of mild COVID-19 diagnosed in Wuhan Jianghan module Hospital from February 6,2020 to February 26,2020 were gathered,and the cases with/without fever were retrospectively analyzed in epidemiology,clinical manifestation,blood routing,hypersensitive C-reactive protein(hs-CRP),pathogens serological testing,chest CT and drugs treatment.Results:For 312 fever cases,the average age was(47.6±10.9)years old,male was 128 cases(41%),the mean peak fever was 38(36.8,38.6)℃,fever lasting was 2(0,3)days,131cases(28.7%)had Huanan seafood market exposure history,90 cases(28.8%)had closely contact with COVID-19 patients,20cases(6.4%)had hypertension history,10 cases(3.2%)had diabetes,5cases(1.6%)had coronary heart disease.Main symptoms of fever group including dry cough of 260cases(83.3%),of 104cases(33.3%),blood sputum of 9cases(2.9%),chest tightness 20cases(19.6%),shortness of breath of 87cases(27.9%),weak of 105cases(33.7%),diarrhea of 43cases(13.8%),sleep disorders of 61cases(19.6%),among fever cases with sputum and shortness of breath more rather without fever,and two groups were statistically significantly difference(P<0.05).In fever group,WBC(109/L)[4.34(3.69,5.26)than 5.11(4.22,6.22),P<0.001],NEUT(109/L)[2.67(2.1,3.49)than 2.88(2.37,3.9),P<0.05],LYM(109/L)[0.9(0.8,1.1)than 1.36(1.03,1.85),P<0.001),PLT(109/L)/(106,188)134-189(132,224),P<0.001)were lower than normal group,while WBC<4.0×109/L[108(34.6%)than 24(16.6%),P<0.001)],LYM<1.0×109/L[189(60.6%)than 31(21.4%),P<0.001)],PLT<100×109/L[45(14.4%)than in 2(1.4%),P<0.001)and hs-CRP(mg/L)[14(6.83,32)than 3.4(0.96,10.75),P<0.001)were higher than normal group,and pathogens serological examination of 36cases shown influenzaⅠ/Ⅱvirus IgM antibody positive in 3cases(8.3%),respiratory syncytial virus IgM antibody positive in 2 cases(5.6%),mycoplasma pneumoniae IgM antibody positive(11.1%),4 cases of adenovirus IgM antibody positive(11.1%),but 4 pathogens of fever group and normal group were no statistical difference(P>0.05).According to early onset of chest CT examination,there were no change of 11cases(2.4%),unilateral lung lesions of 93cases(20.4%),bilateral lung lesions of 353 cases(77.2%),ground glass shadow of 228 cases(73.1%),high density shadow patch of 65 cases(20.8%),consolidation shadow of 6 cases(1.9%),while fever group compared with normal group,there were no statistically significant difference(P>0.05).Logistic regression analysis showed that LYM(OR=0.24,95%CI=0.139~0.415,P<0.001),LYM<1.0 x 109/L(OR=5.12,95%CI=3.07~8.65,P<0.001),PLT<100×109/L(OR=6.1,95%CI=1.36~27.33,P<0.05),and the hs-CRP(OR=1.03,95%CI=1.02~1.05,P<0.001)were fever independent impact factors in mild COVID-19.Aiming at COVID-19 treatment,Chinese medicine usage had 416cases(91%),antiviral drugs had 328cases(71.8%),and antibiotics had 172cases(37.6%),furthermore,fever group using antiviral and antibiotic drugs was higher than normal group(P<0.05),and compared to low fever group,high fever group used more antibiotic drugs(P<0.05).Conclusions:Mild COVID-19 patients with early onset had epidemiological characteristics,and fever,dry cough,expectoration and shortness of breath were main symptoms,and chest CT often involved bilateral lung lesions,ground glass shadow and patch density shadow.The fever patients in WBC,LYM,PLT,hs-CRP index changed significantly and could affect on anti-infective therapy selection.
