A rare earth Schiff base complex:lanthanum tris(N-phenylethyl-3,5-di-t-butylsalicylaldiminato)s [La(OPEBS)_3] was successfully applied as single component initiator for the ring-opening polymerization of 1,4-dioxan-2-...A rare earth Schiff base complex:lanthanum tris(N-phenylethyl-3,5-di-t-butylsalicylaldiminato)s [La(OPEBS)_3] was successfully applied as single component initiator for the ring-opening polymerization of 1,4-dioxan-2-one (PDO) in bulk.The influence of reaction conditions,such as polymerization temperature,the molar ratio of the monomer to initiator (M/I) on the monomer conversion and molecular weight of the polymer has been investigated.Poly(1,4-dioxan-2-one) with a viscosity-average molecular weight (My...展开更多
By means of both a theory for pressure-induced shifts(PS) energy spectra and a theory for shifts of energy spectra due to electron-phonon interaction(EPIP.the pure electronic PS and the PS due to EPI of R1 line,R2 lin...By means of both a theory for pressure-induced shifts(PS) energy spectra and a theory for shifts of energy spectra due to electron-phonon interaction(EPIP.the pure electronic PS and the PS due to EPI of R1 line,R2 line,and U band of GSGG:Cr^3+ at 300 K have been calculated,respectively.The calcualted results are in good agreement with all the experimental data.Their physical origins have also been explained.It is found that the mixingdegree of t2^2(^3T1)e^4T2) and |t2^3 3E>base-wavefunctions in the wavefunctions of R1 level of GSGG:Cr^3+ at 300K is remarkable under normal pressure,and the mixing-degree rapidly decreases with increasing pressure.The change of the mixing-degree with pressure plays a key role not only for the pure electronic'PS of R1 line and R2 line but also the PS of R1 line and R2 line due to EPI.The pressure-dependent behaviors of the pure electronic 'PS of R1 line(or R2 line) and the PS of R1 line(or R2 line) due to EPI are quite different.It is the combined effect of them that gives rise to the total PS of R1 line(or R2 line).In the range of about 15 kar-45kbar,the mergence and /or order-reversal between t2^2(3T1)e^4T2 levels and t2^32T1 levels take place,which cause the fluctuation of the rate of PS for t2^2(3T1)e^4T2(or t2^32T1) with pressure,At 300K,both the temperature-dependent contribution to R1 line(Or R2 line or U band) from EPI and the temperature-independent one are important.展开更多
采用AM1和Ab Initio DFT方法,对3-(吡啶-2)-4-(喹啉-4)-吡唑(PQP) 进行了量子化学计算,给出了分子的几何构型、前沿分子轨道组成与能级、前沿轨道电子密度、原子的净电荷、键级等参数.结果表明PQP分子的稳定构型呈蝴蝶状,分子中的所有N...采用AM1和Ab Initio DFT方法,对3-(吡啶-2)-4-(喹啉-4)-吡唑(PQP) 进行了量子化学计算,给出了分子的几何构型、前沿分子轨道组成与能级、前沿轨道电子密度、原子的净电荷、键级等参数.结果表明PQP分子的稳定构型呈蝴蝶状,分子中的所有N原子和C18、C21等原子很可能是它与TβR-I作用时的活性位点.展开更多
E2A is involved in promoting forkhead box P3(FOXP3) and retinoid-related orphan receptor gamma t(RORγt) gene transcription, which are pivotal transcription factors of T regulatory cells and Th17 cells, respectively. ...E2A is involved in promoting forkhead box P3(FOXP3) and retinoid-related orphan receptor gamma t(RORγt) gene transcription, which are pivotal transcription factors of T regulatory cells and Th17 cells, respectively. Little is known about the involvement of E2 A in pregnancy process. This study aimed to investigate the expression of E2 A, cytotoxic T-lymphocyte-associated protein 4(CTLA-4), and Foxp3 in luteal phase endometrium of women suffering recurrent miscarriage(RM)(n=21) and control group(n=11) by immunohistochemistry, with the Vectra? automated quantitative pathology imaging system for analysis. The percentage of E2 A+ cells and CTLA-4+ cells was significantly higher in the endometrium of women with RM than in the controls. There was positive correlation between E2 A and CTLA-4(r=0.523, P=0.002), E2 A and FOXP3(r=0.380, P=0.032), and FOXP3 and CTLA-4(r=0.625, P=0.000) in the mid-secretory phase of endometrium for all subjects. It was concluded that the abnormal expression of endometrial E2 A existed in mid-secretory endometrium of women with RM, and there was a positive correlation between E2 A and FOXP3, and E2 A and CTLA-4, suggesting the possible regulation role of E2 A involved in regulating endometrium receptivity.展开更多
As one of the 2D transition metal sulfides,1T phase MoS_(2) nanosheets(NSs)have been studied because of their distinguished conductivity and suitable electronic structure.Nevertheless,the active sites are limited to a...As one of the 2D transition metal sulfides,1T phase MoS_(2) nanosheets(NSs)have been studied because of their distinguished conductivity and suitable electronic structure.Nevertheless,the active sites are limited to a small number of edge sites only,while the basal plane is catalytically inert.Herein,we report that boron(B)doped 1T phase MoS_(2) NSs can replace precious metals as a co-catalyst to assist in photocatalytic H_(2) production of 2D layered g-C_(3)N_(4) nanosheets(g-C_(3)N_(4) NSs).The H_(2) evolution rate of prepared B-MoS_(2)@g-C_(3)N_(4) composites with 15 wt%B-MoS_(2)(B-MoS_(2)@g-C_(3)N_(4)–15,1612.75μmol h^(−1) g^(−1))is 52.33 times of pure g-C_(3)N_(4) NSs(30.82μmol h^(−1) g^(−1)).Furthermore,the apparent quantum efficiency(AQE)of B-MoS_(2)@g-C_(3)N_(4)–15 composites under the light atλ=370 nm is calculated and reaches 5.54%.The excellent photocatalytic performance of B-MoS_(2)@g-C_(3)N_(4)–15 composites is attributed to the B ions doping inducing the distortion of 1T phase MoS_(2) crystal,which can activate more base planes to offer more active sites for H_(2) evolution reaction(HER).This work of B-MoS_(2)@g-C_(3)N_(4) composites offers experience in the progress of effective and low-price photocatalysts for HER.展开更多
Objective:To explore the effect of the protease inhibitor from Agaricus bisporus(J.E.Lange)Imbach(AbPI)on glucose uptake and oxidative stress in 3 T3-L1 adipocytes.Methods:Adipocytes were differentiated and stained wi...Objective:To explore the effect of the protease inhibitor from Agaricus bisporus(J.E.Lange)Imbach(AbPI)on glucose uptake and oxidative stress in 3 T3-L1 adipocytes.Methods:Adipocytes were differentiated and stained with OilRed-O staining to confirm adipogenesis.The toxic/protective effect of AbPI on the adipocytes was determined by MTT assay,intracellular reactive oxygen species generation through flow cytometry,and morphologically through confocal microscopy using propidium iodide,4,6-diamino-2-phenylindol dihydrochloride,and 2’,7’-dichlorofluorescein diacetate dyes.The uptake of fluorescent glucose analog,2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-d-glucose by adipocytes was also studied through confocal microscopy.Results:MTT assay showed that the cell survival rate was(28.00±3.00)%,(92.33±2.60)%,and(71.34±2.10)%in the presence of 2 mM H2O2,AbPI alone,and AbPI and H2O2 both,respectively,in comparison to the control.Oil-Red-O staining indicated that Ab PI enhanced adipogenesis.AbPI stimulated the glucose uptake by adipocytes similar to the drug rosiglitazone,and showed insulinsensitizing effect in the presence of insulin,but failed to stimulate the uptake in the absence of insulin.Intracellular reactive oxygen species generation was reduced in differentiating adipocytes upon Ab PI treatment.Confocal microscopy showed that the damaged cell population rose to 3.50%,117.84%,and 261.50%in the presence of Ab PI alone,AbPI with H2O2,and H2O2 alone,respectively.Conclusions:The protease inhibitor enhances glucose uptake by adipocytes and exhibits a cytoprotective effect on them.展开更多
基金supported by the National Natural Science Foundation of China (Key program,Nos.G20434020 and G20774078).
文摘A rare earth Schiff base complex:lanthanum tris(N-phenylethyl-3,5-di-t-butylsalicylaldiminato)s [La(OPEBS)_3] was successfully applied as single component initiator for the ring-opening polymerization of 1,4-dioxan-2-one (PDO) in bulk.The influence of reaction conditions,such as polymerization temperature,the molar ratio of the monomer to initiator (M/I) on the monomer conversion and molecular weight of the polymer has been investigated.Poly(1,4-dioxan-2-one) with a viscosity-average molecular weight (My...
文摘By means of both a theory for pressure-induced shifts(PS) energy spectra and a theory for shifts of energy spectra due to electron-phonon interaction(EPIP.the pure electronic PS and the PS due to EPI of R1 line,R2 line,and U band of GSGG:Cr^3+ at 300 K have been calculated,respectively.The calcualted results are in good agreement with all the experimental data.Their physical origins have also been explained.It is found that the mixingdegree of t2^2(^3T1)e^4T2) and |t2^3 3E>base-wavefunctions in the wavefunctions of R1 level of GSGG:Cr^3+ at 300K is remarkable under normal pressure,and the mixing-degree rapidly decreases with increasing pressure.The change of the mixing-degree with pressure plays a key role not only for the pure electronic'PS of R1 line and R2 line but also the PS of R1 line and R2 line due to EPI.The pressure-dependent behaviors of the pure electronic 'PS of R1 line(or R2 line) and the PS of R1 line(or R2 line) due to EPI are quite different.It is the combined effect of them that gives rise to the total PS of R1 line(or R2 line).In the range of about 15 kar-45kbar,the mergence and /or order-reversal between t2^2(3T1)e^4T2 levels and t2^32T1 levels take place,which cause the fluctuation of the rate of PS for t2^2(3T1)e^4T2(or t2^32T1) with pressure,At 300K,both the temperature-dependent contribution to R1 line(Or R2 line or U band) from EPI and the temperature-independent one are important.
文摘采用AM1和Ab Initio DFT方法,对3-(吡啶-2)-4-(喹啉-4)-吡唑(PQP) 进行了量子化学计算,给出了分子的几何构型、前沿分子轨道组成与能级、前沿轨道电子密度、原子的净电荷、键级等参数.结果表明PQP分子的稳定构型呈蝴蝶状,分子中的所有N原子和C18、C21等原子很可能是它与TβR-I作用时的活性位点.
基金supported by the grants from National Natural Science Foundation of China(No.81401276,No.81771618 and No.81771662)the Fund Project of Health and Family Planning Commission of Hubei Province(No.WJ2015MA006 and No.WJ2015Q017)
文摘E2A is involved in promoting forkhead box P3(FOXP3) and retinoid-related orphan receptor gamma t(RORγt) gene transcription, which are pivotal transcription factors of T regulatory cells and Th17 cells, respectively. Little is known about the involvement of E2 A in pregnancy process. This study aimed to investigate the expression of E2 A, cytotoxic T-lymphocyte-associated protein 4(CTLA-4), and Foxp3 in luteal phase endometrium of women suffering recurrent miscarriage(RM)(n=21) and control group(n=11) by immunohistochemistry, with the Vectra? automated quantitative pathology imaging system for analysis. The percentage of E2 A+ cells and CTLA-4+ cells was significantly higher in the endometrium of women with RM than in the controls. There was positive correlation between E2 A and CTLA-4(r=0.523, P=0.002), E2 A and FOXP3(r=0.380, P=0.032), and FOXP3 and CTLA-4(r=0.625, P=0.000) in the mid-secretory phase of endometrium for all subjects. It was concluded that the abnormal expression of endometrial E2 A existed in mid-secretory endometrium of women with RM, and there was a positive correlation between E2 A and FOXP3, and E2 A and CTLA-4, suggesting the possible regulation role of E2 A involved in regulating endometrium receptivity.
基金fundings from the National Natural Science Foundation of China(No.51872173)Taishan Scholars Program of Shandong Province(No.tsqn201812068)+1 种基金Natural Science Foundation of Shandong Province(No.ZR2022JQ21)Higher School Youth Innovation Team of Shandong Province(No.2019KJA013).
文摘As one of the 2D transition metal sulfides,1T phase MoS_(2) nanosheets(NSs)have been studied because of their distinguished conductivity and suitable electronic structure.Nevertheless,the active sites are limited to a small number of edge sites only,while the basal plane is catalytically inert.Herein,we report that boron(B)doped 1T phase MoS_(2) NSs can replace precious metals as a co-catalyst to assist in photocatalytic H_(2) production of 2D layered g-C_(3)N_(4) nanosheets(g-C_(3)N_(4) NSs).The H_(2) evolution rate of prepared B-MoS_(2)@g-C_(3)N_(4) composites with 15 wt%B-MoS_(2)(B-MoS_(2)@g-C_(3)N_(4)–15,1612.75μmol h^(−1) g^(−1))is 52.33 times of pure g-C_(3)N_(4) NSs(30.82μmol h^(−1) g^(−1)).Furthermore,the apparent quantum efficiency(AQE)of B-MoS_(2)@g-C_(3)N_(4)–15 composites under the light atλ=370 nm is calculated and reaches 5.54%.The excellent photocatalytic performance of B-MoS_(2)@g-C_(3)N_(4)–15 composites is attributed to the B ions doping inducing the distortion of 1T phase MoS_(2) crystal,which can activate more base planes to offer more active sites for H_(2) evolution reaction(HER).This work of B-MoS_(2)@g-C_(3)N_(4) composites offers experience in the progress of effective and low-price photocatalysts for HER.
文摘Objective:To explore the effect of the protease inhibitor from Agaricus bisporus(J.E.Lange)Imbach(AbPI)on glucose uptake and oxidative stress in 3 T3-L1 adipocytes.Methods:Adipocytes were differentiated and stained with OilRed-O staining to confirm adipogenesis.The toxic/protective effect of AbPI on the adipocytes was determined by MTT assay,intracellular reactive oxygen species generation through flow cytometry,and morphologically through confocal microscopy using propidium iodide,4,6-diamino-2-phenylindol dihydrochloride,and 2’,7’-dichlorofluorescein diacetate dyes.The uptake of fluorescent glucose analog,2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-d-glucose by adipocytes was also studied through confocal microscopy.Results:MTT assay showed that the cell survival rate was(28.00±3.00)%,(92.33±2.60)%,and(71.34±2.10)%in the presence of 2 mM H2O2,AbPI alone,and AbPI and H2O2 both,respectively,in comparison to the control.Oil-Red-O staining indicated that Ab PI enhanced adipogenesis.AbPI stimulated the glucose uptake by adipocytes similar to the drug rosiglitazone,and showed insulinsensitizing effect in the presence of insulin,but failed to stimulate the uptake in the absence of insulin.Intracellular reactive oxygen species generation was reduced in differentiating adipocytes upon Ab PI treatment.Confocal microscopy showed that the damaged cell population rose to 3.50%,117.84%,and 261.50%in the presence of Ab PI alone,AbPI with H2O2,and H2O2 alone,respectively.Conclusions:The protease inhibitor enhances glucose uptake by adipocytes and exhibits a cytoprotective effect on them.
