Objective： Stage N2-3 nasopharyngeal carcinoma（NPC） shows a high risk of distant metastasis, which will finally cause death. This study aimed to evaluate the impact of neoadjuvant chemotherapy（NACT） of various cy...Objective： Stage N2-3 nasopharyngeal carcinoma（NPC） shows a high risk of distant metastasis, which will finally cause death. This study aimed to evaluate the impact of neoadjuvant chemotherapy（NACT） of various cycles before radical radiotherapy on distant metastasis and survival of patients with stage N2-3 diseases.Methods： In this study, a total of 1,164 consecutive patients with non-metastatic N2-3 NPC were recruited and prospectively observed. Then 231 patients who received NACT of 4 cycles（NACT=4 group） were matched 1：2：1 to 462 patients treated with NACT of 2 cycles（NACT=2 group） and 231 patients treated without NACT（NACT=0 group）, according to age, histological subtype, N stage and NACT regimen. Five candidate variables（sex, T stage, concurrent chemotherapy, intensity-modulated radiation therapy and cycle number of NACT） were analyzed for their association with patients＇ survival.Results： After matching, the overall survival（OS）, disease-free survival（DFS）, local-recurrence-free survival（RFS） and distant-metastasis-free survival（MFS） of the NACT=4 group（89.2%, 81.0%, 83.3% and 84.8%,respectively） were better than those of the NACT=2 group（83.3%, 72.5%, 81.2% and 77.9%, respectively） and the NACT=0 group（74.0%, 63.2%, 74.0% and 68.8%, respectively）. In multivariate analysis, the cycle number of NACT maintained statistical significance on the OS, DFS, RFS and MFS（all P〈0.05）.Conclusions： For N2-3 NPC, cycle number of NACT appeared to be an independent factor associated with an improvement of survival.展开更多
It is proved that the quadratic system with a weak focus and a strong focus has at most one limit cycle around the strong focus, and as the weak focus is a 2nd order(or 3rd order) weak focus the quadratic system ha...It is proved that the quadratic system with a weak focus and a strong focus has at most one limit cycle around the strong focus, and as the weak focus is a 2nd order(or 3rd order) weak focus the quadratic system has at most two(one) limit cycles which have (1,1) distribution ((0,1) distribution).展开更多
Using the method of life cycle assessment (LCA), the paper studies systematically on municipal solid waste incineration and ecological engineering treatment in Guanghan City. The results showed that the environmental...Using the method of life cycle assessment (LCA), the paper studies systematically on municipal solid waste incineration and ecological engineering treatment in Guanghan City. The results showed that the environmental impact potentials of incineration and ecological engineering treatment is 4\^89×10 -2 and 1\^23×10 -2 respectively ; the net energy consumption is -3\^44×10 2 MJ/ton and -2\^90×10 1 MJ/ton, respectively; the net treatment cost is 84.76 RMB Yuan/ton and 32\^52 RMB Yuan/ton, respectively. Comparing with sole incineration, ecological engineering integrates the advantages of incineration and composing, which not only can reduce the amount of waste for incineration and decrease the second environmental pollution, but also can produce high quality compound fertilizer by adding certain amount of chemical fertilizer into compost. It is proved that ecological engineering treatment is an environmental sustainable and economic afforadably method.展开更多
Let G = （V, E） be a simple graph. A function f ： E → {＋1,-1} is called a signed cycle domination function （SCDF） of G if ∑e∈E（C） f（e） ≥ 1 for every induced cycle C of G. The signed cycle domination numbe...Let G = （V, E） be a simple graph. A function f ： E → {＋1,-1} is called a signed cycle domination function （SCDF） of G if ∑e∈E（C） f（e） ≥ 1 for every induced cycle C of G. The signed cycle domination number of G is defined as γ′sc（G） = min{∑e∈E f（e）｜ f is an SCDF of G}. This paper will characterize all maxima] planar graphs G with order n ≥ 6 and γ′sc（G） =n.展开更多
In China, a nationwide research program on fatigue behaviour of tubular joints made of China-made platform steel was carried out from 1983 to 1990, which was set by the Tubular Joint Research Committee for Offshore St...In China, a nationwide research program on fatigue behaviour of tubular joints made of China-made platform steel was carried out from 1983 to 1990, which was set by the Tubular Joint Research Committee for Offshore Structures (TJCOS) of China. This paper gives an outline of the basic properties of the China-made platform steel and fatigue test of tubular joints, including test specimens, test particulars and test results. A p-S-N curve based on the test results was established which reveals that the fatigue strength of tubular joints is fairly good. The thickness effect and effect of corrosion on fatigue strength in sea water are briefly discussed.展开更多
This paper proposes a technique that uses the number of oscillation cycles(NOC)of a VCO-based comparator to set multiple adaptive bypass windows in a 12-bit successive approximation register(SAR)analog-to-digital conv...This paper proposes a technique that uses the number of oscillation cycles(NOC)of a VCO-based comparator to set multiple adaptive bypass windows in a 12-bit successive approximation register(SAR)analog-to-digital converter(ADC).The analysis of the number of bit cycles,power and static performance shows that three adaptive bypass windows reduce power consumption,and decrease DNL and have similar INL,compared with the SAR ADC without bypass windows.In addition,a 1-bit split-and-recombination redundancy technique and a general bypass logic digital error correction method are proposed to address the settling issues and optimize the size of the bypass window.This design is implemented in 40 nm CMOS technology.The conversion frequency of the ADC reaches up to 30 MS/s.The ADC achieves an SFDR of 85.35 dB and 11.12-bit ENOB with Nyquist input,consuming 380μW,down from 427μW without multiple adaptive bypass windows,at a 1.1 V supply,resulting in a figure of merit(FoM)of 5.69 fJ/conversion-step.展开更多
A type of new loop algebra GM is constructed by making use of the concept of cycled numbers. As its application, an isospectral problem is designed and a new multi-component integrable hierarchy with multi-potential f...A type of new loop algebra GM is constructed by making use of the concept of cycled numbers. As its application, an isospectral problem is designed and a new multi-component integrable hierarchy with multi-potential functions is worked out, which can be reduced to the famous KN hierarchy.展开更多
The objective of this research is to study the effect of grinding powdered superplasticizer, Portland cement, sand, and silica fume on the properties of fresh and hardened concrete. Lose Angeles Machine was used to gr...The objective of this research is to study the effect of grinding powdered superplasticizer, Portland cement, sand, and silica fume on the properties of fresh and hardened concrete. Lose Angeles Machine was used to grind these constituents. The program was arranged to determine the effect of cycles＇ number, superplasticizer type and dosage, silica fume dosage and condition, and gravel to sand ratio on properties of concrete. Naphthalene sulphonated formaldehyde （NSF） superplasticizers in the forms of liquid and powdered were used. Silica fume may be grinded with the other constituents （grinded）, or added to concrete mixer （normal）. The water/cement （w/c） ratio varied from 0.35 to 0.55 to achieve a constant slump （50-90 mm）. Slumps, bulk density and mechanical properties of concrete were measured. Scanning electron microscope （SEM） was also used to show the differences between traditional and superplasticized concrete. The results showed that grinding the mixture enhances fresh and hardened concrete properties. It is also observed that grinding the mixture for 500 cycles is more effective than other numbers of grinding. In addition, superplasticized concrete exhibits compressive strength higher than traditional one at varied ages. Moreover, using powdered superplasticizer has a remarkable effect on enhancing concrete properties rather than using it in a liquid form. A dosage of 1% by weight of cement gave the highest results of compressive strength. Silica fume has an essential role in improving concrete strength and durability since it acts as very efficient void filler and as a super pozzolana. SEM observations illustrate that grinding the mixture enhances transition zone （TZ） properties and makes it denser. On the other hand, grinded mixture can be packaged in bags and transported for use in crowded cities, and so, enhances quality control, since the only requirement to obtain superplasticized concrete is to add water and gravel. This technique has many benefits such as; saving cement, labor and noise, high quality control, and enhancing concrete permeability and durability. There are many fields of application of superplasticized concrete such as; in locations which are not easily accessible by ordinary concreting techniques, in repairing and strengthen, thin coating, and for small projects when ready mix supply is not feasible.展开更多
The cycle coatrol function is defined and used to estimate tbe number of limit cycles for someplanar autonomous systems. Some sufficient conditions for the existence of no or at most one limitcycles are given.
The present study attempts to investigate the effect of moisture conditioning on the in- direct tensile strength （ITS） of cold recycled mixture with bitumen emulsion. Firstly, samples were prepared using a Superpave...The present study attempts to investigate the effect of moisture conditioning on the in- direct tensile strength （ITS） of cold recycled mixture with bitumen emulsion. Firstly, samples were prepared using a Superpave gyratory compactor. They were hence condi- tioned using moisture induced sensitivity tester （MIST） device. Factorial design was carried out considering four factors each at two different levels. These factors were specimen thickness, air voids content, pressure and number of cycles. In the MIST device, samples are cyclically subjected to water pressure through the sample pores. The MIST conditioned samples were tested for indirect tensile strength. The analysis of two-level full-factorial designed experiments revealed that all four factors have a negative effect on tensile strength of cold recycled mixture with bitumen emulsion. Specimen thickness was the most significant factor affecting the tensile strength followed by air voids content. In two- factor interaction, specimen thickness-number of cycles, air voids content-pressure, and pressure-number of cycles were significant. The most significant three-factor interaction was specimen thickness-pressure-number of cycles. The results from the study suggest that in measuring tensile strength, the appropriate specimen thickness and air voids content should be selected to quantify the representative tensile strength for in-situ conditions.展开更多
A reliability assessment method of fatigue life based on the long-term monitoring data is developed for welded details in steel box girder,and the application research is presented with examples of welded rib-to-deck ...A reliability assessment method of fatigue life based on the long-term monitoring data is developed for welded details in steel box girder,and the application research is presented with examples of welded rib-to-deck details in Runyang Bridges. Firstly the fatigue damage limit-state function is established based on S-N curves and Miner's rule,and the probability distribution characteristics of the coefficients in the function are discussed in detail. The uncertainties in fatigue loading effects are mainly studied based on long-term monitoring data. In the traditional studies,only the uncertainty of equivalent stress range is considered in fatigue reliability assessment. However,stress cycle number is also treated as a random variable in this paper because we know traffic flow every day differs in a thousand ways. Then the optimization method is employed to calculate the fatigue reliability. After studying the changing law of the reliability indices with time and the effect of the randomness of stress cycle number on reliability,the effect of the traffic growth on the reliability is studied. This study shows that the uncertainty in the fatigue life of the welded details can be well studied based on structural health monitoring,so it is necessary to carry out long-term strain monitoring of the welded details for accurate fatigue reliability assessment during the whole service period.展开更多
High-pressure homogenization （HPH） technology was applied as a pretreatment to disintegrate sewage sludge. The effects of homogenization pressure, homogenization cycle number, and total solid content on sludge disin...High-pressure homogenization （HPH） technology was applied as a pretreatment to disintegrate sewage sludge. The effects of homogenization pressure, homogenization cycle number, and total solid content on sludge disintegration were investigated. The sludge disintegration degree （DDCOD）, protein concentration, and polysaccharide concentration increased with the increase of homogenization pressure and homogenization cycle number, and decreased with the increase of sludge total solid （TS） content. The maximum DDCOD of 43.94% was achieved at 80 MPa with four homogenization cycles for a 9.58 g/L TS sludge sample. A HPH sludge disintegration model of DDCOD= kNaPb was established by multivariable linear regression to quantify the effects of homogenization parameters. The homogenization cycle exponent a and homogenization pressure exponent b were 0.4763 and 0.7324 respectively, showing that the effect of homogenization pressure （P） was more significant than that of homogenization cycle number （N）. The value of the rate constant k decreased with the increase of sludge total solid content. The specific energy consumption increased with the increment of sludge disintegration efficiency. Lower specific energy consumption was required for higher total solid content sludge.展开更多
As a new energy storage element,supercapacitors have characteristics such as high power density,fast charge and discharge rates,green environmental protection,and long cycle life.Temperature is an important parameter ...As a new energy storage element,supercapacitors have characteristics such as high power density,fast charge and discharge rates,green environmental protection,and long cycle life.Temperature is an important parameter of supercapacitors which significantly influences the stability of the supercapacitors.In this study,the finite element method is used to realize a coupling between a one-dimensional electrochemical model and a three-dimensional thermal model.Then,based on this model,the concept of limited cycle numbers is defined,and different unit quantities,unit size,and the effect of temperature under different temperature environments such as low temperature,room temperature,and high temperature on stacked-type supercapacitors is studied.Finally,stacked-type supercapacitors are compared with rolled-type supercapacitors considering the same cell size,density,and volume approximations.The simulation results show that the higher the number of packaging units,the lower is the limit cycle number.This phenomenon is more pronounced under high current than under low current conditions.Increasing the package size of the porous electrode or separator decreases the limiting cycles.Under the same unit volume scenario,improving the separator size proportion can accurately control the temperature rise at small current values.Under the same material,volume,and density approximations,the temperature rises slowly for stacked-type supercapacitors as compared to rolled-type supercapacitors.This phenomenon is more pronounced with an increase in current.展开更多
Objective： To investigate the mechanism of moxibustion in regulating cellular apoptosis in rat＇s precancerous lesion of primary hepatocellular carcinoma （HCC）. Methods： Seventy-four rats were randomly allocated t...Objective： To investigate the mechanism of moxibustion in regulating cellular apoptosis in rat＇s precancerous lesion of primary hepatocellular carcinoma （HCC）. Methods： Seventy-four rats were randomly allocated to normal group, model group and moxibustion group, and the diethylic nitrosamine （DEN） was used to establish HCC model. Moxibustion with moxa cone which is as big as a grain of wheat was performed on acupoint Zusanli （ST 36）, 3 cones for each acupoint and 0.5 mg for each cone, the treatment was given once a day, totally 16 weeks. Then the changes in the body weight, liver weight and thymus weight, a morphological change in the liver tissue and changes in γ-GT and GST were observed; Immunohistochemical staining method was adopted to observe the tendency of changes in relevant apoptosis genes such as C-myc, N-ras and mutant type P53, and the influence of moxibustion on cell cycle modulation genes such as cyclinD1, CDK4 and pl6. Results： Moxibustion could reduce the activities of γ-GT and GST in the blood, obviously decrease the protein expression of relevant apoptosis genes such as C-myc, N-ras and mutant type P53 and markedly inhibit the over-expression of relevant cell cycle modulation genes such as cyclinD1 and CDK4 and the mutation of cell cycle modulation gene pl 6. Conclusion： Moxibustion might play a certain role in relieving HCC precancerous lesion and its action mechanism might be related to the regulation on partial apoptosis genes.展开更多
基金supported by the Science and Technology Planning Project of Guangdong Province, China (Grant No. 2017A020215157)
文摘Objective： Stage N2-3 nasopharyngeal carcinoma（NPC） shows a high risk of distant metastasis, which will finally cause death. This study aimed to evaluate the impact of neoadjuvant chemotherapy（NACT） of various cycles before radical radiotherapy on distant metastasis and survival of patients with stage N2-3 diseases.Methods： In this study, a total of 1,164 consecutive patients with non-metastatic N2-3 NPC were recruited and prospectively observed. Then 231 patients who received NACT of 4 cycles（NACT=4 group） were matched 1：2：1 to 462 patients treated with NACT of 2 cycles（NACT=2 group） and 231 patients treated without NACT（NACT=0 group）, according to age, histological subtype, N stage and NACT regimen. Five candidate variables（sex, T stage, concurrent chemotherapy, intensity-modulated radiation therapy and cycle number of NACT） were analyzed for their association with patients＇ survival.Results： After matching, the overall survival（OS）, disease-free survival（DFS）, local-recurrence-free survival（RFS） and distant-metastasis-free survival（MFS） of the NACT=4 group（89.2%, 81.0%, 83.3% and 84.8%,respectively） were better than those of the NACT=2 group（83.3%, 72.5%, 81.2% and 77.9%, respectively） and the NACT=0 group（74.0%, 63.2%, 74.0% and 68.8%, respectively）. In multivariate analysis, the cycle number of NACT maintained statistical significance on the OS, DFS, RFS and MFS（all P〈0.05）.Conclusions： For N2-3 NPC, cycle number of NACT appeared to be an independent factor associated with an improvement of survival.
文摘It is proved that the quadratic system with a weak focus and a strong focus has at most one limit cycle around the strong focus, and as the weak focus is a 2nd order(or 3rd order) weak focus the quadratic system has at most two(one) limit cycles which have (1,1) distribution ((0,1) distribution).
文摘Using the method of life cycle assessment (LCA), the paper studies systematically on municipal solid waste incineration and ecological engineering treatment in Guanghan City. The results showed that the environmental impact potentials of incineration and ecological engineering treatment is 4\^89×10 -2 and 1\^23×10 -2 respectively ; the net energy consumption is -3\^44×10 2 MJ/ton and -2\^90×10 1 MJ/ton, respectively; the net treatment cost is 84.76 RMB Yuan/ton and 32\^52 RMB Yuan/ton, respectively. Comparing with sole incineration, ecological engineering integrates the advantages of incineration and composing, which not only can reduce the amount of waste for incineration and decrease the second environmental pollution, but also can produce high quality compound fertilizer by adding certain amount of chemical fertilizer into compost. It is proved that ecological engineering treatment is an environmental sustainable and economic afforadably method.
基金Supported by Doctoral Scientific Research Fund of Harbin Normal University(Grant No.KGB201008)
文摘Let G = （V, E） be a simple graph. A function f ： E → {＋1,-1} is called a signed cycle domination function （SCDF） of G if ∑e∈E（C） f（e） ≥ 1 for every induced cycle C of G. The signed cycle domination number of G is defined as γ′sc（G） = min{∑e∈E f（e）｜ f is an SCDF of G}. This paper will characterize all maxima] planar graphs G with order n ≥ 6 and γ′sc（G） =n.
文摘In China, a nationwide research program on fatigue behaviour of tubular joints made of China-made platform steel was carried out from 1983 to 1990, which was set by the Tubular Joint Research Committee for Offshore Structures (TJCOS) of China. This paper gives an outline of the basic properties of the China-made platform steel and fatigue test of tubular joints, including test specimens, test particulars and test results. A p-S-N curve based on the test results was established which reveals that the fatigue strength of tubular joints is fairly good. The thickness effect and effect of corrosion on fatigue strength in sea water are briefly discussed.
基金supported by the National Natural Science Foundation of China under Grant 61534002 and Grant 61761136015.
文摘This paper proposes a technique that uses the number of oscillation cycles(NOC)of a VCO-based comparator to set multiple adaptive bypass windows in a 12-bit successive approximation register(SAR)analog-to-digital converter(ADC).The analysis of the number of bit cycles,power and static performance shows that three adaptive bypass windows reduce power consumption,and decrease DNL and have similar INL,compared with the SAR ADC without bypass windows.In addition,a 1-bit split-and-recombination redundancy technique and a general bypass logic digital error correction method are proposed to address the settling issues and optimize the size of the bypass window.This design is implemented in 40 nm CMOS technology.The conversion frequency of the ADC reaches up to 30 MS/s.The ADC achieves an SFDR of 85.35 dB and 11.12-bit ENOB with Nyquist input,consuming 380μW,down from 427μW without multiple adaptive bypass windows,at a 1.1 V supply,resulting in a figure of merit(FoM)of 5.69 fJ/conversion-step.
基金The project supported by National Natural Science Foundation of China under.Grant No. 10371070
文摘A type of new loop algebra GM is constructed by making use of the concept of cycled numbers. As its application, an isospectral problem is designed and a new multi-component integrable hierarchy with multi-potential functions is worked out, which can be reduced to the famous KN hierarchy.
文摘The objective of this research is to study the effect of grinding powdered superplasticizer, Portland cement, sand, and silica fume on the properties of fresh and hardened concrete. Lose Angeles Machine was used to grind these constituents. The program was arranged to determine the effect of cycles＇ number, superplasticizer type and dosage, silica fume dosage and condition, and gravel to sand ratio on properties of concrete. Naphthalene sulphonated formaldehyde （NSF） superplasticizers in the forms of liquid and powdered were used. Silica fume may be grinded with the other constituents （grinded）, or added to concrete mixer （normal）. The water/cement （w/c） ratio varied from 0.35 to 0.55 to achieve a constant slump （50-90 mm）. Slumps, bulk density and mechanical properties of concrete were measured. Scanning electron microscope （SEM） was also used to show the differences between traditional and superplasticized concrete. The results showed that grinding the mixture enhances fresh and hardened concrete properties. It is also observed that grinding the mixture for 500 cycles is more effective than other numbers of grinding. In addition, superplasticized concrete exhibits compressive strength higher than traditional one at varied ages. Moreover, using powdered superplasticizer has a remarkable effect on enhancing concrete properties rather than using it in a liquid form. A dosage of 1% by weight of cement gave the highest results of compressive strength. Silica fume has an essential role in improving concrete strength and durability since it acts as very efficient void filler and as a super pozzolana. SEM observations illustrate that grinding the mixture enhances transition zone （TZ） properties and makes it denser. On the other hand, grinded mixture can be packaged in bags and transported for use in crowded cities, and so, enhances quality control, since the only requirement to obtain superplasticized concrete is to add water and gravel. This technique has many benefits such as; saving cement, labor and noise, high quality control, and enhancing concrete permeability and durability. There are many fields of application of superplasticized concrete such as; in locations which are not easily accessible by ordinary concreting techniques, in repairing and strengthen, thin coating, and for small projects when ready mix supply is not feasible.
文摘The cycle coatrol function is defined and used to estimate tbe number of limit cycles for someplanar autonomous systems. Some sufficient conditions for the existence of no or at most one limitcycles are given.
基金supported by the National Natural Science Foundation of China(grant No.51308477)
文摘The present study attempts to investigate the effect of moisture conditioning on the in- direct tensile strength （ITS） of cold recycled mixture with bitumen emulsion. Firstly, samples were prepared using a Superpave gyratory compactor. They were hence condi- tioned using moisture induced sensitivity tester （MIST） device. Factorial design was carried out considering four factors each at two different levels. These factors were specimen thickness, air voids content, pressure and number of cycles. In the MIST device, samples are cyclically subjected to water pressure through the sample pores. The MIST conditioned samples were tested for indirect tensile strength. The analysis of two-level full-factorial designed experiments revealed that all four factors have a negative effect on tensile strength of cold recycled mixture with bitumen emulsion. Specimen thickness was the most significant factor affecting the tensile strength followed by air voids content. In two- factor interaction, specimen thickness-number of cycles, air voids content-pressure, and pressure-number of cycles were significant. The most significant three-factor interaction was specimen thickness-pressure-number of cycles. The results from the study suggest that in measuring tensile strength, the appropriate specimen thickness and air voids content should be selected to quantify the representative tensile strength for in-situ conditions.
基金supported by the National Natural Science Foundation of China (Grant Nos.50725828,50808041)Scientific Research Foundation of Graduate School of Southeast University (Grant No. YBJJ0923)Teaching and Research Foundation for Excellent Young Teacher of Southeast University
文摘A reliability assessment method of fatigue life based on the long-term monitoring data is developed for welded details in steel box girder,and the application research is presented with examples of welded rib-to-deck details in Runyang Bridges. Firstly the fatigue damage limit-state function is established based on S-N curves and Miner's rule,and the probability distribution characteristics of the coefficients in the function are discussed in detail. The uncertainties in fatigue loading effects are mainly studied based on long-term monitoring data. In the traditional studies,only the uncertainty of equivalent stress range is considered in fatigue reliability assessment. However,stress cycle number is also treated as a random variable in this paper because we know traffic flow every day differs in a thousand ways. Then the optimization method is employed to calculate the fatigue reliability. After studying the changing law of the reliability indices with time and the effect of the randomness of stress cycle number on reliability,the effect of the traffic growth on the reliability is studied. This study shows that the uncertainty in the fatigue life of the welded details can be well studied based on structural health monitoring,so it is necessary to carry out long-term strain monitoring of the welded details for accurate fatigue reliability assessment during the whole service period.
基金supported by the China-Israel Joint Research Program, MOST of Chinathe National Natural Science Foundation of China (No. 51178047)the Foundation of Key Laboratory for Solid Waste Management and Environment Safety,Ministry of Education of China (No. SWMES 2010-2)
文摘High-pressure homogenization （HPH） technology was applied as a pretreatment to disintegrate sewage sludge. The effects of homogenization pressure, homogenization cycle number, and total solid content on sludge disintegration were investigated. The sludge disintegration degree （DDCOD）, protein concentration, and polysaccharide concentration increased with the increase of homogenization pressure and homogenization cycle number, and decreased with the increase of sludge total solid （TS） content. The maximum DDCOD of 43.94% was achieved at 80 MPa with four homogenization cycles for a 9.58 g/L TS sludge sample. A HPH sludge disintegration model of DDCOD= kNaPb was established by multivariable linear regression to quantify the effects of homogenization parameters. The homogenization cycle exponent a and homogenization pressure exponent b were 0.4763 and 0.7324 respectively, showing that the effect of homogenization pressure （P） was more significant than that of homogenization cycle number （N）. The value of the rate constant k decreased with the increase of sludge total solid content. The specific energy consumption increased with the increment of sludge disintegration efficiency. Lower specific energy consumption was required for higher total solid content sludge.
文摘As a new energy storage element,supercapacitors have characteristics such as high power density,fast charge and discharge rates,green environmental protection,and long cycle life.Temperature is an important parameter of supercapacitors which significantly influences the stability of the supercapacitors.In this study,the finite element method is used to realize a coupling between a one-dimensional electrochemical model and a three-dimensional thermal model.Then,based on this model,the concept of limited cycle numbers is defined,and different unit quantities,unit size,and the effect of temperature under different temperature environments such as low temperature,room temperature,and high temperature on stacked-type supercapacitors is studied.Finally,stacked-type supercapacitors are compared with rolled-type supercapacitors considering the same cell size,density,and volume approximations.The simulation results show that the higher the number of packaging units,the lower is the limit cycle number.This phenomenon is more pronounced under high current than under low current conditions.Increasing the package size of the porous electrode or separator decreases the limiting cycles.Under the same unit volume scenario,improving the separator size proportion can accurately control the temperature rise at small current values.Under the same material,volume,and density approximations,the temperature rises slowly for stacked-type supercapacitors as compared to rolled-type supercapacitors.This phenomenon is more pronounced with an increase in current.
文摘Objective： To investigate the mechanism of moxibustion in regulating cellular apoptosis in rat＇s precancerous lesion of primary hepatocellular carcinoma （HCC）. Methods： Seventy-four rats were randomly allocated to normal group, model group and moxibustion group, and the diethylic nitrosamine （DEN） was used to establish HCC model. Moxibustion with moxa cone which is as big as a grain of wheat was performed on acupoint Zusanli （ST 36）, 3 cones for each acupoint and 0.5 mg for each cone, the treatment was given once a day, totally 16 weeks. Then the changes in the body weight, liver weight and thymus weight, a morphological change in the liver tissue and changes in γ-GT and GST were observed; Immunohistochemical staining method was adopted to observe the tendency of changes in relevant apoptosis genes such as C-myc, N-ras and mutant type P53, and the influence of moxibustion on cell cycle modulation genes such as cyclinD1, CDK4 and pl6. Results： Moxibustion could reduce the activities of γ-GT and GST in the blood, obviously decrease the protein expression of relevant apoptosis genes such as C-myc, N-ras and mutant type P53 and markedly inhibit the over-expression of relevant cell cycle modulation genes such as cyclinD1 and CDK4 and the mutation of cell cycle modulation gene pl 6. Conclusion： Moxibustion might play a certain role in relieving HCC precancerous lesion and its action mechanism might be related to the regulation on partial apoptosis genes.
