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Multi-Objective Optimization of Multi-Product Parallel Disassembly Line Balancing Problem Considering Multi-Skilled Workers Using a Discrete Chemical Reaction Optimization Algorithm
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作者 Xiwang Guo Liangbo Zhou +4 位作者 Zhiwei Zhang Liang Qi Jiacun Wang Shujin Qin Jinrui Cao 《Computers, Materials & Continua》 SCIE EI 2024年第9期4475-4496,共22页
This work investigates a multi-product parallel disassembly line balancing problem considering multi-skilled workers.A mathematical model for the parallel disassembly line is established to achieve maximized disassemb... This work investigates a multi-product parallel disassembly line balancing problem considering multi-skilled workers.A mathematical model for the parallel disassembly line is established to achieve maximized disassembly profit and minimized workstation cycle time.Based on a product’s AND/OR graph,matrices for task-skill,worker-skill,precedence relationships,and disassembly correlations are developed.A multi-objective discrete chemical reaction optimization algorithm is designed.To enhance solution diversity,improvements are made to four reactions:decomposition,synthesis,intermolecular ineffective collision,and wall invalid collision reaction,completing the evolution of molecular individuals.The established model and improved algorithm are applied to ball pen,flashlight,washing machine,and radio combinations,respectively.Introducing a Collaborative Resource Allocation(CRA)strategy based on a Decomposition-Based Multi-Objective Evolutionary Algorithm,the experimental results are compared with four classical algorithms:MOEA/D,MOEAD-CRA,Non-dominated Sorting Genetic Algorithm Ⅱ(NSGA-Ⅱ),and Non-dominated Sorting Genetic Algorithm Ⅲ(NSGA-Ⅲ).This validates the feasibility and superiority of the proposed algorithm in parallel disassembly production lines. 展开更多
关键词 Parallel disassembly line balancing problem MULTI-PRODUCT multiskilled workers discrete chemical reaction optimization algorithm
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Experimental Study on the Reduction Effect of Pit Texture on Disassembly Damage for Interference Fit
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作者 Dan Zhou Yi Xu +2 位作者 Xin Gao Haihong Huang Songjiang Lv 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2023年第2期249-260,共12页
After remanufacturing disassembly,several kinds of friction damages can be found on the mating surface of interference fit.These damages should be repaired and the cost is closely related to the severity of damages.In... After remanufacturing disassembly,several kinds of friction damages can be found on the mating surface of interference fit.These damages should be repaired and the cost is closely related to the severity of damages.Inspired by the excellent performance of surface texture in wear reduction,5 shapes of pit array textures are added to the specimens’surface to study their reduction effect of disassembly damage for interference fit.The results of disassembly experiments show that the order of influence of texture parameters on disassembly damage is as follows:equivalent circle diameter of single texture,texture shape and texture surface density.The influence of equivalent circle diameter of single texture and texture shape are obviously more significant than that of texture surface density.The circular texture with a surface density of 30%and a diameter of 100μm shows an excellent disassembly damage reduction effect because of its perfect ability of abrasive particle collection.And the probability of disassembly damage formation and evolution is also relatively small on this kind of textured surface.Besides,the load-carrying capacity of interference fit with the excellent texture is confirmed by load-carrying capacity experiments.The results show that the load-carrying capacity of the excellent texture surface is increased about 40%compared with that of without texture.This research provides a potential approach to reduce disassembly damage for interference fit. 展开更多
关键词 REMANUFACTURING Interference fit disassembly damage Surface texture Load-carrying capacity
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Using genetic/simulated annealing algorithm to solve disassembly sequence planning 被引量:5
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作者 Wu Hao Zuo Hongfu 《Journal of Systems Engineering and Electronics》 SCIE EI CSCD 2009年第4期906-912,共7页
Disassembly sequence planning (DSP) plays a significant role in maintenance planning of the aircraft. It is used during the design stage for the analysis of maintainability of the aircraft. To solve product disassem... Disassembly sequence planning (DSP) plays a significant role in maintenance planning of the aircraft. It is used during the design stage for the analysis of maintainability of the aircraft. To solve product disassembly sequence planning problems efficiently, a product disassembly hybrid graph model, which describes the connection, non-connection and precedence relationships between the product parts, is established based on the characteristic of disassembly. Farther, the optimization model is provided to optimize disassembly sequence. And the solution methodology based on the genetic/simulated annealing algorithm with binaxy-tree algorithm is given. Finally, an example is analyzed in detail, and the result shows that the model is correct and efficient. 展开更多
关键词 disassembly sequence planning disassembly hybrid graph connection matrix precedence matrix binary-tree algorithms simulated annealing algorithm genetic algorithm.
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Automated Disassembly Sequence Prediction for Industry 4.0 Using Enhanced Genetic Algorithm
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作者 Anil Kumar Gulivindala M.V.A.Raju Bahubalendruni +3 位作者 R.Chandrasekar Ejaz Ahmed Mustufa Haider Abidi Abdulrahman Al-Ahmari 《Computers, Materials & Continua》 SCIE EI 2021年第11期2531-2548,共18页
The evolution of Industry 4.0 made it essential to adopt the Internet of Things(IoT)and Cloud Computing(CC)technologies to perform activities in the new age of manufacturing.These technologies enable collecting,storin... The evolution of Industry 4.0 made it essential to adopt the Internet of Things(IoT)and Cloud Computing(CC)technologies to perform activities in the new age of manufacturing.These technologies enable collecting,storing,and retrieving essential information from the manufacturing stage.Data collected at sites are shared with others where execution automatedly occurs.The obtained information must be validated at manufacturing to avoid undesirable data losses during the de-manufacturing process.However,information sharing from the assembly level at the manufacturing stage to disassembly at the product end-of-life state is a major concern.The current research validates the information optimally to offer a minimum set of activities to complete the disassembly process.An optimal disassembly sequence plan(DSP)can possess valid information to organize the necessary actions in manufacturing.However,finding an optimal DSP is complex because of its combinatorial nature.The genetic algorithm(GA)is a widely preferred artificial intelligence(AI)algorithm to obtain a near-optimal solution for the DSP problem.The converging nature at local optima is a limitation in the traditional GA.This study improvised the GA workability by integrating with the proposed priori crossover operator.An optimality function is defined to reduce disassembly effort by considering directional changes as parameters.The enhanced GA method is tested on a real-time product to evaluate the performance.The obtained results reveal that diversity control depends on the operators employed in the disassembly attributes.The proposed method’s solution can be stored in the cloud and shared through IoT devices for effective resource allocation and disassembly for maximum recovery of the product.The effectiveness of the proposed enhanced GA method is determined by making a comparative assessment with traditional GA and other AI methods at different population sizes. 展开更多
关键词 AUTOMATION internet of things disassembly sequence planning priori cross over operator enhanced GA disassembly predicates
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Disassemblability Modeling Technology of Configurable Product Based on Disassembly Constraint Relation Weighted Design Structure Matrix(DSM) 被引量:3
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作者 QIU Lemiao LIU Xiaojian +1 位作者 ZHANG Shuyou SUN Liangfeng 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2014年第3期511-519,共9页
The current research of configurable product disassemblability focuses on disassemblability evaluation and disassembly sequence planning. Little work has been done on quantitative analysis of configurable product disa... The current research of configurable product disassemblability focuses on disassemblability evaluation and disassembly sequence planning. Little work has been done on quantitative analysis of configurable product disassemblability. The disassemblability modeling technology for configurable product based on disassembly constraint relation weighted design structure matrix (DSM) is proposed. Major factors affecting the disassemblability of configurable product are analyzed, and the disassembling degrees between components in configurable product are obtained by calculating disassembly entropies such as joint type, joint quantity, disassembly path, disassembly accessibility and material compatibility. The disassembly constraint relation weighted DSM of configurable product is constructed and configuration modules are formed by matrix decomposition and tearing operations. The disassembly constraint relation in configuration modules is strong coupling, and the disassembly constraint relation between modules is weak coupling, and the disassemblability configuration model is constructed based on configuration module. Finally, taking a hydraulic forging press as an example, the decomposed weak coupling components are used as configuration modules alone, components with a strong coupling are aggregated into configuration modules, and the disassembly sequence of components inside configuration modules is optimized by tearing operation. A disassemblability configuration model of the hydraulic forging press is constructed. By researching the disassemblability modeling technology of product configuration design based on disassembly constraint relation weighted DSM, the disassembly property in maintenance, recycling and reuse of configurable product are optimized. 展开更多
关键词 disassemblability modeling disassembly entropy disassembling degree weighted DSM product configuration model
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Disassembly Sequence Planning:A Survey 被引量:2
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作者 Xiwang Guo MengChu Zhou +2 位作者 Abdullah Abusorrah Fahad Alsokhiry Khaled Sedraoui 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2021年第7期1308-1324,共17页
It is well-recognized that obsolete or discarded products can cause serious environmental pollution if they are poorly be handled.They contain reusable resource that can be recycled and used to generate desired econom... It is well-recognized that obsolete or discarded products can cause serious environmental pollution if they are poorly be handled.They contain reusable resource that can be recycled and used to generate desired economic benefits.Therefore,performing their efficient disassembly is highly important in green manufacturing and sustainable economic development.Their typical examples are electronic appliances and electromechanical/mechanical products.This paper presents a survey on the state of the art of disassembly sequence planning.It can help new researchers or decision makers to search for the right solution for optimal disassembly planning.It reviews the disassembly theory and methods that are applied for the processing,repair,and maintenance of obsolete/discarded products.This paper discusses the recent progress of disassembly sequencing planning in four major aspects:product disassembly modeling methods,mathematical programming methods,artificial intelligence methods,and uncertainty handling.This survey should stimulate readers to be engaged in the research,development and applications of disassembly and remanufacturing methodologies in the Industry 4.0 era. 展开更多
关键词 Artificial intelligence(AI) disassembly sequence planning(DSP) intelligent optimization modeling methods multiobjective optimization single-objective optimization uncertainty.
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Neighborhood Modularization‑based Artificial Bee Colony Algorithm for Disassembly Planning with Operation Attributes 被引量:1
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作者 Hongfei Guo Linsheng Zhang +3 位作者 Yaping Ren Leilei Meng Zhongwei Zhou Jianqing Li 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2022年第6期165-177,共13页
The recycling and remanufacturing of end-of-life products are significant for environmental protection and resource conservation.Disassembly is an essential process of remanufacturing end-of-life products.Effective di... The recycling and remanufacturing of end-of-life products are significant for environmental protection and resource conservation.Disassembly is an essential process of remanufacturing end-of-life products.Effective disassembly plans help improve disassembly efficiency and reduce disassembly costs.This paper studies a disassembly planning problem with operation attributes,in which an integrated decision of the disassembly sequence,disassembly directions,and disassembly tools are made.Besides,a mathematical model is formulated with the objective of minimizing the penalty cost caused by the changing of operation attributes.Then,a neighborhood modularization-based artificial bee colony algorithm is developed,which contains a modular optimized design.Finally,two case studies with different scales and complexities are used to verify the performance of the proposed approach,and experimental results show that the proposed algorithm outperforms the two existing methods within an acceptable computational time. 展开更多
关键词 End-of-life products disassembly planning Artificial bee colony Neighborhood modularization
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STUDY ON HUMAN-COMPUTER SYSTEM FOR STABLE VIRTUAL DISASSEMBLY 被引量:1
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作者 GuanQiang ZhangShensheng +2 位作者 LiuJihong CaoPengbing ZhongYifang 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2003年第3期277-280,291,共5页
The cooperative work between human being and computer based on virtual reality (VR) is investigated to plan the disassembly sequences more efficiently. A three-layer model of human-computer cooperative virtual disasse... The cooperative work between human being and computer based on virtual reality (VR) is investigated to plan the disassembly sequences more efficiently. A three-layer model of human-computer cooperative virtual disassembly is built, and the corresponding human-computer system for stable virtual disassembly is developed. In this system, an immersive and interactive virtual disassembly environment has been created to provide planners with a more visual working scene. For cooperative disassembly, an intelligent module of stability analysis of disassembly operations is embedded into the human-computer system to assist planners to implement disassembly tasks better. The supporting matrix for stability analysis of disassembly operations is defined and the method of stability analysis is detailed. Based on the approach, the stability of any disassembly operation can be analyzed to instruct the manual virtual disassembly. At last, a disassembly case in the virtual environment is given to prove the validity of above ideas. 展开更多
关键词 Virtual disassembly Human-computer system Virtual reality Stability analysis
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Assembly and disassembly of mammalian chromosome pellicle
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作者 NIZUMEI JELITTLE 《Cell Research》 SCIE CAS CSCD 1992年第2期195-201,共7页
By means of indirect double immunofluorescent staining, the coordination of PI antigen and perichromonucleolin (PCN), the constituent of nuclear periphery and nucleolus respectively, in the assembly and disassembly of... By means of indirect double immunofluorescent staining, the coordination of PI antigen and perichromonucleolin (PCN), the constituent of nuclear periphery and nucleolus respectively, in the assembly and disassembly of chromosome pellicle during mitosis was studied. It was found that in 3T3 cells, during mitosis PI antigen began to coat the condensing chromosome .surface earlier.than PCN did. However, both of them completed their coating on chromosome at approximately the same stage of mitosis, prometaphase metaphase. The dissociation of PI antigen from chromosome pellicle to participate the formation of nuclear periphery took, place also ahead of that of PCN. At early telophase PI antigen had been extensively involved in the formation of nuclear periphery, while PCN remained in association with the surface of decondensing chromosomes. At late telophase, when PI antigen was localized in an fairly well formed nuclear periphery, PCN was in a stage of forming prenucleolar bodies. 展开更多
关键词 chromosome pellicle ASSEMBLY disassembly PI antigen perichrmnonucleolin (PCN) indirect double imnuinofluorescenl staining mitosis.
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End-of-life vehicle recycling based on disassembly
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作者 王翔 秦晔 +1 位作者 陈铭 王成焘 《Journal of Central South University》 SCIE EI CAS 2005年第S2期153-156,共4页
The end-of-life vehicle recycling was studied based on the disassembly. The end-of-life recycling and the disassembly were reviewed and discussed. A disassembly experiment of an end-of-life engine was carried out, whi... The end-of-life vehicle recycling was studied based on the disassembly. The end-of-life recycling and the disassembly were reviewed and discussed. A disassembly experiment of an end-of-life engine was carried out, which strictly recorded the process of dismantling. Based on the results, a model of the end-of-life recycling was presented. In this model, the end-of-life parts were classified by three ways which included to recycle directly, to recycle after remanufacturing and to discard. By using this model, the dismantling efficiency and the recycling rate can be improved. Also, it obtains a good result after used in a dismantling factory. 展开更多
关键词 END-OF-LIFE VEHICLE RECYCLING disassembly
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Crystal Structure of Sar1[H79G]-GDP Which Provides Insight into the Coat-controlled GTP Hydrolysis in the Disassembly of COP Ⅱ
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作者 RAO Yi-Jian YUAN Cai BIAN Chuan-Bing HOU Xiao-Min LI Yong-Dong ZHAO Geng-Xiang YE Xiao-Ming HUANG Zi-Xiang HUANG Ming-Dong 《Chinese Journal of Structural Chemistry》 SCIE CAS CSCD 北大核心 2006年第7期854-860,共7页
Sarl is a small GTPase involved in COPⅡ vesicle transport. Previous studies showed that H79G mutation of Sarl can lock Sarl in its GTP-bound active conformation, stabilize coat assembly, and prevent the disassembly o... Sarl is a small GTPase involved in COPⅡ vesicle transport. Previous studies showed that H79G mutation of Sarl can lock Sarl in its GTP-bound active conformation, stabilize coat assembly, and prevent the disassembly of COP Ⅱ vesicle coats by reducing Sec23/24 GAP- stimulated hydrolysis. We show here that the replacement of His79 by glycine induces a large conformation change in switch Ⅱ and results in the lost of hydrogen bond between His79 and its associated nucleophilic water molecule that was hypothesized to reduce the GAP-stimulated hydrolysis during the COP Ⅱ assembly and disassembly. These results confirm that the switch Ⅱ conformation is important for COP Ⅱ disassembly through coat-controlled GTP hydrolysis. 展开更多
关键词 Sarl switch COP disassembly crystal structure
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p38 MAP kinase is necessary for melanoma-mediated regulation of VE-cadherin disassembly
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作者 Payal Khanna Avery August 《医用生物力学》 EI CAS CSCD 2010年第S1期16-17,共2页
Introduction Vascular endothelial (VE)-cadherin is localized to the endothelial borders and the adherens junctions,which are regulated by changes in mitogen activated protein kinases (MAPK),GTPases,and intracellular c... Introduction Vascular endothelial (VE)-cadherin is localized to the endothelial borders and the adherens junctions,which are regulated by changes in mitogen activated protein kinases (MAPK),GTPases,and intracellular calcium. We previously 展开更多
关键词 VE p38 MAP kinase is necessary for melanoma-mediated regulation of VE-cadherin disassembly
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Analysis of Mobile Phone Reliability Based on Active Disassembly Using Smart Materials
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作者 Zhifeng Liu Liuxian Zhao +2 位作者 Jun Zhong Xinyu Li Huanbo Cheng 《Journal of Surface Engineered Materials and Advanced Technology》 2011年第2期80-87,共8页
When using shape memory materials into active disassembly of actual electronic products, because the elastic modulus of shape memory materials is affected by the temperature is relatively large, therefore, the main di... When using shape memory materials into active disassembly of actual electronic products, because the elastic modulus of shape memory materials is affected by the temperature is relatively large, therefore, the main difference of environmental reliability between active disassembly products and common products is the impact of collision and vibration under different temperature. Establishing three-dimensional analysis model, comparing the impact of collision and vibration of mobile phone shells which are made up of PVC materials after casting & radiation and PC/ABS materials under different temperature. Analyzing the reliability of mobile phone under different temperature and optimizing its structure according to data of testing. 展开更多
关键词 Active disassembly Mobile PHONE ENVIRONMENTAL RELIABILITY ANALYSIS of COLLISION ANALYSIS of Vibration
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Disassembly Evaluation in Design of a System Using a Multi-Parameters Index
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作者 Aslain Brisco Ngnassi Djami Wolfgang Nzié Serge Doka Yamigno 《Modern Mechanical Engineering》 2020年第1期1-16,共16页
In order to help designers, consider disassembly in their design activities, a method for evaluation of product disassembly is proposed. Criteria characterizing the disassembility of a product are identified. Each cri... In order to help designers, consider disassembly in their design activities, a method for evaluation of product disassembly is proposed. Criteria characterizing the disassembility of a product are identified. Each criterion is assigned a coefficient, thus proposing an index of easy fixations (Iff) as a design indicator to evaluate the level of disassembly of a solution generated by the designer. This index is calculated as a weighted average of the indicators for evaluating the disassembility of the product. The proposed method uses information such as the list of subsets or parts, the component tree, the part geometry, the functional links between components and parts, the properties of the components. It has been tested on one product: the soy roaster. 展开更多
关键词 DESIGN disassembly CRITERIA EVALUATION INDICATORS
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Research on Anti-collision Algorithm of Short Distance Data communication based on Binary-Tree Disassembly
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作者 Zhongyue Hu 《International Journal of Technology Management》 2014年第8期30-32,共3页
This paper puts forward adaptive anti collision algorithm based on two fork tree decomposition. New search algorithm built on the basis of binary-tree algorithm, using the uniqueness of the label EPC, to estimate the ... This paper puts forward adaptive anti collision algorithm based on two fork tree decomposition. New search algorithm built on the basis of binary-tree algorithm, using the uniqueness of the label EPC, to estimate the distribution of label by slot allocation, the huge and complicated two fork tree is decomposed into several simple binary-tree by search the collision slots for binary-tree, so, it can simplifies the search process. The algorithm fully considers4 important performance parameters of the reader paging times, transmission delay, energy consumption and throughput label, the simulation results show that, the improved anti-collision algorithm is obviously improved performance than other two fork tree algorithm, it is more suitable for RFID anti-collision protocols. 展开更多
关键词 RFID ANTI-COLLISION Binary-tree disassembly
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Disassembly sequence planning using component-joint graph and ant colony optimization
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作者 Zheng Menglei Tian Ling Liu Beibei 《Computer Aided Drafting,Design and Manufacturing》 2016年第1期54-57,共4页
Disassembly sequence planning is an important step of mechanical maintenance. This article presents an integrated study about the generation and optimizing algorithm of the disassembly sequence. Mechanical products ar... Disassembly sequence planning is an important step of mechanical maintenance. This article presents an integrated study about the generation and optimizing algorithm of the disassembly sequence. Mechanical products are divided into two categories of components and connectors. The article uses component-joint graph to represent assembly constraints, including the incidence constraints are represented by incidence matrix and the interference constraints are represented by interference constraints. The inspiring factor and pheromone matrix are calculated according to assembly constraints. Then the ant generates its own disassembly sequences one by one and updates the inspiring factor and pheromone matrix. After all iterations, the best disassembly sequence planning of components and connectors are given. Finally, an application instance of the disassembly sequence of the jack is presented to illustrate the validity of this method. 展开更多
关键词 disassembly sequence planning component-joint graph ant colony algorithms
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A Q-Learning Based Hybrid Meta-Heuristic for Integrated Scheduling of Disassembly and Reprocessing Processes Considering Product Structures and Stochasticity 被引量:1
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作者 Fuquan Wang Yaping Fu +2 位作者 Kaizhou Gao Yaoxin Wu Song Gao 《Complex System Modeling and Simulation》 EI 2024年第2期184-209,共26页
Remanufacturing is regarded as a sustainable manufacturing paradigm of energy conservation and environment protection.To improve the efficiency of the remanufacturing process,this work investigates an integrated sched... Remanufacturing is regarded as a sustainable manufacturing paradigm of energy conservation and environment protection.To improve the efficiency of the remanufacturing process,this work investigates an integrated scheduling problem for disassembly and reprocessing in a remanufacturing process,where product structures and uncertainty are taken into account.First,a stochastic programming model is developed to minimize the maximum completion time(makespan).Second,a Q-learning based hybrid meta-heuristic(Q-HMH)is specially devised.In each iteration,a Q-learning method is employed to adaptively choose a premium algorithm from four candidate ones,including genetic algorithm(GA),artificial bee colony(ABC),shuffled frog-leaping algorithm(SFLA),and simulated annealing(SA)methods.At last,simulation experiments are carried out by using sixteen instances with different scales,and three state-of-the-art algorithms in literature and an exact solver CPLEX are chosen for comparisons.By analyzing the results with the average relative percentage deviation(RPD)metric,we find that Q-HMH outperforms its rivals by 9.79%-26.76%.The results and comparisons verify the excellent competitiveness of Q-HMH for solving the concerned problems. 展开更多
关键词 remanufacturing scheduling disassembly REPROCESSING META-HEURISTIC Q-LEARNING
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Enzymatic self-assembly/disassembly turns “ON”/“OFF” the mimetic hydrolytic activity of histidine nanofibers
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作者 Xianbao Sun Manli Wang +6 位作者 Xiaoyang Liu Wenjun Zhan Guangqiong Xu Qiaochu Jiang Hai-Dong Xu Fuqiang Wang Gaolin Liang 《Science China Chemistry》 SCIE EI CAS CSCD 2024年第2期517-522,共6页
Mimetic enzymes are devised as alternates or supplements of natural enzymes in broad fields but regulating their activities in a switchable manner remains challenging.Herein,we proposed an enzymatic self-assembly/disa... Mimetic enzymes are devised as alternates or supplements of natural enzymes in broad fields but regulating their activities in a switchable manner remains challenging.Herein,we proposed an enzymatic self-assembly/disassembly strategy to address this issue.A peptide molecule Nap FFEYIH(YH) was rationally designed which,after self-assembling into nanofibers,lined up the histidine moieties to form active hydrolysis centers for mimicking hydrolase activity.Enzymatic dephosphorylation of Nap FFEYp IH(Yp H) by alkaline phosphatase to yield YH also turned “ON” the hydrolase activity.In turn,phosphorylation of YH by phosphokinase epidermal growth factor receptor to yield Yp H disassembled the nanofibers and thus turned the activity “OFF”.As such,the “ON”/“OFF” of the mimetic hydrolase activities could be regulated under physiological conditions through ALP/EGFR-mediated self-assembly/disassembly of histidine nanofibers.This work provides a feasible strategy for the on-demand fabrication of artificial enzymes with controllable and superior activities. 展开更多
关键词 disassembly hydrolytic activity mimetic enzyme phosphorylation SELF-ASSEMBLY
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Pathologically relevant aldoses and environmental aldehydes cause cilium disassembly via formyl group-mediated mechanisms
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作者 Te Li Min Liu +11 位作者 Fan Yu Song Yang Weiwen Bu Kai Liu Jia Yang Hua Ni Mulin Yang Hanxiao Yin Renjie Hong Dengwen Li Huijie Zhao Jun Zhou 《Journal of Molecular Cell Biology》 SCIE CAS CSCD 2024年第1期15-28,共14页
Carbohydrate metabolism disorders(CMDs),such as diabetes,galactosemia,and mannosidosis,cause ciliopathy-like multiorgan defects.However,the mechanistic link of cilia to CMD complications is still poorly understood.Her... Carbohydrate metabolism disorders(CMDs),such as diabetes,galactosemia,and mannosidosis,cause ciliopathy-like multiorgan defects.However,the mechanistic link of cilia to CMD complications is still poorly understood.Herein,we describe significant cilium disassembly upon treatment of cells with pathologically relevant aldoses rather than the corresponding sugar alcohols.Moreover,environmental aldehydes are able to trigger cilium disassembly by the steric hindrance effect of their formyl groups.Mechanistic studies reveal that aldehydes stimulate extracellular calcium influx across the plasma membrane,which subsequently activates the calmodulin-Aurora A-histone deacetylase 6 pathway to deacetylate axonemal microtubules and triggers cilium disassembly.In vivo experiments further show that Hdac6 knockout mice are resistant to aldehyde-induced disassembly of tracheal cilia and sperm flagella.These findings reveal a previously unrecognized role for formyl group-mediated cilium disassembly in the complications of CMDs. 展开更多
关键词 carbohydrate metabolism disorder ALDOSE ALDEHYDE cilium disassembly formyl group calcium influx HDAC6
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Recent Advances in Activatable Probes for Molecular Imaging by Stimuli-Controlled Disassembly 被引量:1
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作者 Weijing Huang Yanling Yang Deju Ye 《Chinese Journal of Chemistry》 SCIE CAS CSCD 2023年第18期2382-2399,共18页
Comprehensive Summary,Stimuli-controlled disassembly process has shown promise to direct delivery of probes and/or spatial-temporally control imaging signals for molecular imaging in vivo.Via the disassembly process,w... Comprehensive Summary,Stimuli-controlled disassembly process has shown promise to direct delivery of probes and/or spatial-temporally control imaging signals for molecular imaging in vivo.Via the disassembly process,well defined nanoprobes with a stimulus-responsive moiety can be controllably converted into small-molecular imaging agents in response to a stimulus,leading to a switch in imaging signals.Moreover,the on-site released small-molecule probes could enhance penetration into the deep tissue for improved imaging of deep-seated molecular targets.Therefore,such a stimuli-controllable disassembly approach has been widely utilized to build activatable molecular imaging probes for the noninvasive detection of various molecular targets in living subjects.In this review article,we first briefly introduce the general principle of stimuli-controlled disassembly.We then summarize the activatable probes based on different internal or external stimulus that has been utilized to control disassembly process.Activatable probes by using multiple stimuli to control cascaded in situ self-assembly and disassembly processes are also discussed.Finally,we close with a conclusion of current challenges and perspective in this field. 展开更多
关键词 Stimuli-controlled disassembly Activatable probes Small-molecular imaging agents SELF-ASSEMBLY Molecular imaging
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