Administrative regions are an important environment for the operation of China's market economy.The relevant economic subjects cannot predict the policy of adjustment of administrative divisions and carry out cons...Administrative regions are an important environment for the operation of China's market economy.The relevant economic subjects cannot predict the policy of adjustment of administrative divisions and carry out conscious migration behavior,adjustment of administrative divisions can be regarded as a quasi-natural experiment.The three cities of Hefei,Wuhu,and Ma'anshan,which are directly related to the adjustment of the administrative division of Chaohu,are taken as the treatment group,and the seven adjacent cities of Lu'an,Huainan,Chuzhou,Bengbu,Anqing,Chizhou,and Tongling are taken as the control group.Differences-in-Differences method and relevant control variables affecting the upgrading of industrial structure are used to test.The test results show that"Partitions of Chaohu"has a significant industrial structure upgrading effect by promoting the optimization of spatial layout,the cross-regional flow of production factors and the effective management of Chaohu Lake Basin.At the same time,the increase of total retail sales of consumer goods,urban fixed assets investment,public utility expenses in science,education,culture and health,and population plays a significant positive role in promoting the upgrading of industrial structure,while foreign direct investment plays a certain inhibition role in the upgrading of industrial structure.In order to meet the ever-developing space demands and enhance the impact on surrounding areas,the Hefei metropolitan area should be driven by technological innovation,strengthen the integration of industrial chains,improve the business environment and transportation network,and continuously promote the upgrading of industrial structure and the formation and development of new productive forces.展开更多
In this work, we present a general theoretical study leading to analytical expression of the seasonal temperature at the near surface that is expected to evaluate any area seasonal temperature of the world using the l...In this work, we present a general theoretical study leading to analytical expression of the seasonal temperature at the near surface that is expected to evaluate any area seasonal temperature of the world using the least square method to fit the hourly data to the theoretical curve of the temperature. It is shown that the temperature is globally the result of two contributions: the contribution of the revolution movement of the terrestrial globe on its elliptical orbit around the sun, the contribution of the spin-orbit coupling for the rotation movement of the terrestrial globe around its polar axis and its revolution movement. The orbital behavior of the temperature is used to find the seasonal divisions of the climate for the local area considered. The whole expression of the temperature is very useful for the meteorological needs. The contribution of the human activities and natural instabilities are the results of discrepancies which increase errors (standard deviations).展开更多
The seasonality and day-to-day variation of near-surface temperature patterns can greatly control nearly all physical and biological processes though temperature predictions at such scales remain challenging. This pap...The seasonality and day-to-day variation of near-surface temperature patterns can greatly control nearly all physical and biological processes though temperature predictions at such scales remain challenging. This paper implements a simple analytical approach in order to generate daily average temperatures which implicitly accounts for surface heating and drivers through a comprehensive representation of station-based temperature records on a universal standard calendar propagated by the earth’s dynamics features. The modeled and observed pattern of daily temperatures exhibits a close agreement with the level of strength agreement exceeding 0.56. The extreme high and low values of the observed temperature patterns are equally well captured although model underestimates the probability of temperatures around the two modal peaks (~25.6℃ and 27.5℃). Additionally, a theoretical thermal-based division led to the identification of six seasons, including two hot and cold periods along with two pairs of mixed hot-cold. The theoretical division proposed here appears to be a good approximation for the understanding of rainfall seasonality in this area.展开更多
The tango of life begins with the very first cell division.New research reveals that to dance their way through development,dividing cells must pass along not just DNA but molecular“memories”that guide their destini...The tango of life begins with the very first cell division.New research reveals that to dance their way through development,dividing cells must pass along not just DNA but molecular“memories”that guide their destinies.When this handoff gets fumbled,the dance falls apart.展开更多
The Belle Corporation is a Chinese domestic shoe maker and seller. It also belongs to an industry that has come to be representative of the ubiquitous "Made in China" label. One of the main reasons the compa...The Belle Corporation is a Chinese domestic shoe maker and seller. It also belongs to an industry that has come to be representative of the ubiquitous "Made in China" label. One of the main reasons the company is favored by global investors is due to its unique business pattern-a pattern that sets manufacturing as its base and is active in exploring industrial chain downstream links and establishing its own individual retail channels. Ever since its first inception in the stock market, Belle has set out to acquire several upstream manufacturing companies, indicating its desire for increasing channel terminals. Using a vertically integrated competition strategy, Belle stands out amongst its rivals as being particularly successful in the non-mainstream manufacturing sector. Consequently, its business practices can be used as a model for other domestic manufacturing companies in their efforts to meet the challenges posed by globalization.展开更多
We say a divisien (S = SA or SB, g) is equal if it divides set S into two subsets SA and SB satisfying f (SA) = f (SB), where f is som attribute function on these sets and SA or SB need not be empty. In the present pa...We say a divisien (S = SA or SB, g) is equal if it divides set S into two subsets SA and SB satisfying f (SA) = f (SB), where f is som attribute function on these sets and SA or SB need not be empty. In the present paper, we have obtained some equal divisions on set of ordered tree with n modes: two equal divisions on tree set; two equal divisions on node set; two divisions on leaf set, one is equal, another one is ''asymptotically'' equal. We conclude that, ordered tree set is on its good behavior in equal dividing.展开更多
Guo Moruo (Kuo Mojo, 1892-1978), specialist in Chinese history, philologist, writer and social activist. His original name was Kuo Kaizhen and his self-styled name was Shangwu. On November 16 1892, he was born in the ...Guo Moruo (Kuo Mojo, 1892-1978), specialist in Chinese history, philologist, writer and social activist. His original name was Kuo Kaizhen and his self-styled name was Shangwu. On November 16 1892, he was born in the town of Shawan in Leshan County, Sichuan Province.From the autumn.of 1907 to the summer of 1913, he was a pupil at the Jiadingfu Middle School and the展开更多
In line with the overall Objectives set out in the"Outline Scheme for the Academic Divisions of theChinese Academy of Sciences (CAS) during theNinth Five-year Plan (1996-2000)," CAS has donea good job of the...In line with the overall Objectives set out in the"Outline Scheme for the Academic Divisions of theChinese Academy of Sciences (CAS) during theNinth Five-year Plan (1996-2000)," CAS has donea good job of the supplementary election of CASmembers and the development of the virtues ofscience and fine style of research. In addihon, con-sultation and appraisal, academic exchanges, andthe popularization of science have progressivelybeen focuses of the academic divisions, and manyaccomplishments have been achieved in these areas.展开更多
The Academic Divisions of the Chinese Academy of Sciences (CAS) are vitally important and integral parts of the academy and were founded in June 1, 1955, six years after the establishment of the CAS. This was an impor...The Academic Divisions of the Chinese Academy of Sciences (CAS) are vitally important and integral parts of the academy and were founded in June 1, 1955, six years after the establishment of the CAS. This was an important event for both the CAS and the Chinese S&T community. The institution, which is composed of the most excellent Chinese scientists, has played an active role in strengthening the academic leadership of China’s S&T undertakings. Over the 40-odd years of ups and downs, the development of Academic Divisions could be characterized by four phases: laying the foundation展开更多
The Resolution on Several Major Issues for Strengthening Socialist Civic Ethics adopted by the Sixth Plenary Session of the Party’s 14th Congress states that "socialist ethics is a major feature of socialist soc...The Resolution on Several Major Issues for Strengthening Socialist Civic Ethics adopted by the Sixth Plenary Session of the Party’s 14th Congress states that "socialist ethics is a major feature of socialist society, a great goal and an important guarantee for the modernization drive.The promotion of socialist morality bears closely on the accomplishment of the grand trans-century plan and the prosperity and development of the socialist cause". To do a good job in enhancing socialist ethics is of great practical importance and profound historical significance to the great cause of building up socialism with its own Chinese characters in the country, to the implementation of the two fundamental changes, and to the enforcement of the development strategy of revitalizing China by science and education and this country’s sustainable develop-展开更多
In January 1984, the Academic Divisions of the CAS,which was established in 1955, held its fifth General Assembly after experiencing 30 years of trials and hardships, marking the beginning of a new period of flourishi...In January 1984, the Academic Divisions of the CAS,which was established in 1955, held its fifth General Assembly after experiencing 30 years of trials and hardships, marking the beginning of a new period of flourishing development.Ten years passed between the fifth assembly and the seventh one,which was held in June 1994.It was in this decade that the Academic Divisions gradually assumed the practice of the international science community according to the domestic situation and international convention by making clear the nature and functions of the Academic Divisions and of their Members, renaming Division Mem-展开更多
On the eve of the 11th General Assembly of the Chinese Academy of Sciences (CAS), the CAS Presidium briefed the press on the important advances achieved by the Academic Divisions (ADs) over the past two years.
The Academic Divisions of the Chinese Academy of Sciences (CAS), the highest advisory body of the State in science and technology, made encouraging progress over the year 2001.
Seismo-tectonic areas of historical strong earthquakes with MS(7 along Xianshuihe-Xiaojiang fault zone are divided, and their individual fault-pattern and tectonic geomorphology are analyzed. Those strong-earthquake a...Seismo-tectonic areas of historical strong earthquakes with MS(7 along Xianshuihe-Xiaojiang fault zone are divided, and their individual fault-pattern and tectonic geomorphology are analyzed. Those strong-earthquake areas are located in some special parts of the fault zone, where the major branch-faults of the fault zone form left stepping, parallel, and fork-like patterns. In the strong-earthquake areas structurally complicated basins are developed, such as pull-apart basins in fork-like area, in double stepping area, and in stepping and fork-like areas.展开更多
Administrative division is an important means of political power reorganization and management,resource integration and optimal allocation,which profoundly shapes the spatial layout of urban development in China.To cl...Administrative division is an important means of political power reorganization and management,resource integration and optimal allocation,which profoundly shapes the spatial layout of urban development in China.To clarify and compare differences between counties,county-level cities and municipal districts is the primary premise for the study of administrative division and urban development.This paper analyzes the institutional differences between counties and county-level cities,as well as counties,county-level cities and municipal districts,from the aspects of organizational structure,urban construction planning,land management,finance,taxation and public services.The research shows that the establishment of counties,county-level cities and municipal districts adapt to different levels and stages of economic and social development,and the conversion from county to county-level city and the conversion from county(or county-level city)to municipal district are both important transformation ways to change their administrative systems,which has different management system and operation pattern.At the same time,the transformation of county-level administrative region is also a“double-edged sword”,we should think about the administrative system as a whole to decide whether it should be adjusted,and effectively respond to the actual needs of local economic and social development.展开更多
Today’s forensic science introduces a new research area for digital image analysis formultimedia security.So,Image authentication issues have been raised due to the wide use of image manipulation software to obtain a...Today’s forensic science introduces a new research area for digital image analysis formultimedia security.So,Image authentication issues have been raised due to the wide use of image manipulation software to obtain an illegitimate benefit or createmisleading publicity by using tempered images.Exiting forgery detectionmethods can classify only one of the most widely used Copy-Move and splicing forgeries.However,an image can contain one or more types of forgeries.This study has proposed a hybridmethod for classifying Copy-Move and splicing images using texture information of images in the spatial domain.Firstly,images are divided into equal blocks to get scale-invariant features.Weber law has been used for getting texture features,and finally,XGBOOST is used to classify both Copy-Move and splicing forgery.The proposed method classified three types of forgeries,i.e.,splicing,Copy-Move,and healthy.Benchmarked(CASIA 2.0,MICCF200)and RCMFD datasets are used for training and testing.On average,the proposed method achieved 97.3% accuracy on benchmarked datasets and 98.3% on RCMFD datasets by applying 10-fold cross-validation,which is far better than existing methods.展开更多
Weakly-coupled mode division multiplexing(MDM)technique is considered a promising candidate to enhance the capacity of an optical transmission system,in which mode multiplexers/demultiplexers(MMUX/MDEMUX)with low inse...Weakly-coupled mode division multiplexing(MDM)technique is considered a promising candidate to enhance the capacity of an optical transmission system,in which mode multiplexers/demultiplexers(MMUX/MDEMUX)with low insertion loss and modal crosstalk are the key components.In this paper,a low-modal-crosstalk 4-mode MMUX/MDEMUX for the weakly-coupled triple-ring-core few-mode fiber(TRC-FMF)is designed and fabricated with side-polishing processing.The measurement results show that a pair of MMUX/MDEMUX and 25 km weakly-coupled TRC-FMF MDM link achieve low modal crosstalk of lower than−17.5 dB and insertion loss of lower than 11.56 dB for all the four modes.Based on the TRC-FMF and all-fiber MMUX/MDEMUX,an experiment for 25 km real-time 4-mode 3-λwavelength division multiplexing(WDM)-MDM transmission is conducted using commercial 400G optical transport network(OTN)transceivers.The experimental results prove weakly-coupled MDM techniques facilitate a smooth upgrade of the optical transmission system.展开更多
Background:Considering the increase in the proportion of lung adenocarcinoma(LUAD)cases among all lung cancers and its considerable contribution to cancer-related deaths worldwide,we sought to identify novel oncogenes...Background:Considering the increase in the proportion of lung adenocarcinoma(LUAD)cases among all lung cancers and its considerable contribution to cancer-related deaths worldwide,we sought to identify novel oncogenes to provide potential targets and facilitate a better understanding of the malignant progression of LUAD.Methods:The results from the screening of transcriptome and survival analyses according to the integrated Gene Expression Omnibus(GEO)datasets and The Cancer Genome Atlas(TCGA)data were combined,and a promising risk biomarker called meiotic nuclear divisions 1(MND1)was selectively acquired.Cell viability assays and subcutaneous xenograftmodelswere used to validate the oncogenic role ofMND1 in LUADcell proliferation and tumor growth.Aseries of assays,including mass spectrometry,co-immunoprecipitation(Co-IP),and chromatin immunoprecipitation(ChIP),were performed to explore the underlying mechanism.Results:MND1 up-regulation was identified to be an independent risk factor for overall survival in LUAD patients evaluated by both tissue microarray staining and third party data analysis.In vivo and in vitro assays showed that MND1 promoted LUAD cell proliferation by regulating cell cycle.The results of the Co-IP,ChIP and dual-luciferase reporter assays validated that MND1 competitively bound to tumor suppressor Kruppel-like factor 6(KLF6),and thereby protecting E2F transcription factor 1(E2F1)from KLF6-induced transcriptional repression.Luciferase reporter and ChIP assays found that E2F1 activated MND1 transcription by binding to its promoter in a feedback manner.Conclusions:MND1,KLF6,and E2F1 form a positive feedback loop to regulate cell cycle and confer DDP resistance in LUAD.MND1 is crucial for malignant progression and may be a potential therapeutic target in LUAD patients.展开更多
文摘Administrative regions are an important environment for the operation of China's market economy.The relevant economic subjects cannot predict the policy of adjustment of administrative divisions and carry out conscious migration behavior,adjustment of administrative divisions can be regarded as a quasi-natural experiment.The three cities of Hefei,Wuhu,and Ma'anshan,which are directly related to the adjustment of the administrative division of Chaohu,are taken as the treatment group,and the seven adjacent cities of Lu'an,Huainan,Chuzhou,Bengbu,Anqing,Chizhou,and Tongling are taken as the control group.Differences-in-Differences method and relevant control variables affecting the upgrading of industrial structure are used to test.The test results show that"Partitions of Chaohu"has a significant industrial structure upgrading effect by promoting the optimization of spatial layout,the cross-regional flow of production factors and the effective management of Chaohu Lake Basin.At the same time,the increase of total retail sales of consumer goods,urban fixed assets investment,public utility expenses in science,education,culture and health,and population plays a significant positive role in promoting the upgrading of industrial structure,while foreign direct investment plays a certain inhibition role in the upgrading of industrial structure.In order to meet the ever-developing space demands and enhance the impact on surrounding areas,the Hefei metropolitan area should be driven by technological innovation,strengthen the integration of industrial chains,improve the business environment and transportation network,and continuously promote the upgrading of industrial structure and the formation and development of new productive forces.
文摘In this work, we present a general theoretical study leading to analytical expression of the seasonal temperature at the near surface that is expected to evaluate any area seasonal temperature of the world using the least square method to fit the hourly data to the theoretical curve of the temperature. It is shown that the temperature is globally the result of two contributions: the contribution of the revolution movement of the terrestrial globe on its elliptical orbit around the sun, the contribution of the spin-orbit coupling for the rotation movement of the terrestrial globe around its polar axis and its revolution movement. The orbital behavior of the temperature is used to find the seasonal divisions of the climate for the local area considered. The whole expression of the temperature is very useful for the meteorological needs. The contribution of the human activities and natural instabilities are the results of discrepancies which increase errors (standard deviations).
文摘The seasonality and day-to-day variation of near-surface temperature patterns can greatly control nearly all physical and biological processes though temperature predictions at such scales remain challenging. This paper implements a simple analytical approach in order to generate daily average temperatures which implicitly accounts for surface heating and drivers through a comprehensive representation of station-based temperature records on a universal standard calendar propagated by the earth’s dynamics features. The modeled and observed pattern of daily temperatures exhibits a close agreement with the level of strength agreement exceeding 0.56. The extreme high and low values of the observed temperature patterns are equally well captured although model underestimates the probability of temperatures around the two modal peaks (~25.6℃ and 27.5℃). Additionally, a theoretical thermal-based division led to the identification of six seasons, including two hot and cold periods along with two pairs of mixed hot-cold. The theoretical division proposed here appears to be a good approximation for the understanding of rainfall seasonality in this area.
文摘The tango of life begins with the very first cell division.New research reveals that to dance their way through development,dividing cells must pass along not just DNA but molecular“memories”that guide their destinies.When this handoff gets fumbled,the dance falls apart.
文摘The Belle Corporation is a Chinese domestic shoe maker and seller. It also belongs to an industry that has come to be representative of the ubiquitous "Made in China" label. One of the main reasons the company is favored by global investors is due to its unique business pattern-a pattern that sets manufacturing as its base and is active in exploring industrial chain downstream links and establishing its own individual retail channels. Ever since its first inception in the stock market, Belle has set out to acquire several upstream manufacturing companies, indicating its desire for increasing channel terminals. Using a vertically integrated competition strategy, Belle stands out amongst its rivals as being particularly successful in the non-mainstream manufacturing sector. Consequently, its business practices can be used as a model for other domestic manufacturing companies in their efforts to meet the challenges posed by globalization.
基金Supported by China National Natural Science Foundation.
文摘We say a divisien (S = SA or SB, g) is equal if it divides set S into two subsets SA and SB satisfying f (SA) = f (SB), where f is som attribute function on these sets and SA or SB need not be empty. In the present paper, we have obtained some equal divisions on set of ordered tree with n modes: two equal divisions on tree set; two equal divisions on node set; two divisions on leaf set, one is equal, another one is ''asymptotically'' equal. We conclude that, ordered tree set is on its good behavior in equal dividing.
文摘Guo Moruo (Kuo Mojo, 1892-1978), specialist in Chinese history, philologist, writer and social activist. His original name was Kuo Kaizhen and his self-styled name was Shangwu. On November 16 1892, he was born in the town of Shawan in Leshan County, Sichuan Province.From the autumn.of 1907 to the summer of 1913, he was a pupil at the Jiadingfu Middle School and the
文摘In line with the overall Objectives set out in the"Outline Scheme for the Academic Divisions of theChinese Academy of Sciences (CAS) during theNinth Five-year Plan (1996-2000)," CAS has donea good job of the supplementary election of CASmembers and the development of the virtues ofscience and fine style of research. In addihon, con-sultation and appraisal, academic exchanges, andthe popularization of science have progressivelybeen focuses of the academic divisions, and manyaccomplishments have been achieved in these areas.
文摘The Academic Divisions of the Chinese Academy of Sciences (CAS) are vitally important and integral parts of the academy and were founded in June 1, 1955, six years after the establishment of the CAS. This was an important event for both the CAS and the Chinese S&T community. The institution, which is composed of the most excellent Chinese scientists, has played an active role in strengthening the academic leadership of China’s S&T undertakings. Over the 40-odd years of ups and downs, the development of Academic Divisions could be characterized by four phases: laying the foundation
文摘The Resolution on Several Major Issues for Strengthening Socialist Civic Ethics adopted by the Sixth Plenary Session of the Party’s 14th Congress states that "socialist ethics is a major feature of socialist society, a great goal and an important guarantee for the modernization drive.The promotion of socialist morality bears closely on the accomplishment of the grand trans-century plan and the prosperity and development of the socialist cause". To do a good job in enhancing socialist ethics is of great practical importance and profound historical significance to the great cause of building up socialism with its own Chinese characters in the country, to the implementation of the two fundamental changes, and to the enforcement of the development strategy of revitalizing China by science and education and this country’s sustainable develop-
文摘In January 1984, the Academic Divisions of the CAS,which was established in 1955, held its fifth General Assembly after experiencing 30 years of trials and hardships, marking the beginning of a new period of flourishing development.Ten years passed between the fifth assembly and the seventh one,which was held in June 1994.It was in this decade that the Academic Divisions gradually assumed the practice of the international science community according to the domestic situation and international convention by making clear the nature and functions of the Academic Divisions and of their Members, renaming Division Mem-
文摘On the eve of the 11th General Assembly of the Chinese Academy of Sciences (CAS), the CAS Presidium briefed the press on the important advances achieved by the Academic Divisions (ADs) over the past two years.
文摘The Academic Divisions of the Chinese Academy of Sciences (CAS), the highest advisory body of the State in science and technology, made encouraging progress over the year 2001.
基金Chinese Joint Seismological Science Foundation (9507424). Contribution No. 2001A003, Institute of Crustal Dynamics, China Seis
文摘Seismo-tectonic areas of historical strong earthquakes with MS(7 along Xianshuihe-Xiaojiang fault zone are divided, and their individual fault-pattern and tectonic geomorphology are analyzed. Those strong-earthquake areas are located in some special parts of the fault zone, where the major branch-faults of the fault zone form left stepping, parallel, and fork-like patterns. In the strong-earthquake areas structurally complicated basins are developed, such as pull-apart basins in fork-like area, in double stepping area, and in stepping and fork-like areas.
基金This research was funded by National Natural Science Foundation of China,grant number 41871151.
文摘Administrative division is an important means of political power reorganization and management,resource integration and optimal allocation,which profoundly shapes the spatial layout of urban development in China.To clarify and compare differences between counties,county-level cities and municipal districts is the primary premise for the study of administrative division and urban development.This paper analyzes the institutional differences between counties and county-level cities,as well as counties,county-level cities and municipal districts,from the aspects of organizational structure,urban construction planning,land management,finance,taxation and public services.The research shows that the establishment of counties,county-level cities and municipal districts adapt to different levels and stages of economic and social development,and the conversion from county to county-level city and the conversion from county(or county-level city)to municipal district are both important transformation ways to change their administrative systems,which has different management system and operation pattern.At the same time,the transformation of county-level administrative region is also a“double-edged sword”,we should think about the administrative system as a whole to decide whether it should be adjusted,and effectively respond to the actual needs of local economic and social development.
基金funded by Princess Nourah bint Abdulrahman University Researchers Supporting Project number(PNURSP2024R236),Princess Nourah bint Abdulrahman University,Riyadh,Saudi Arabia.
文摘Today’s forensic science introduces a new research area for digital image analysis formultimedia security.So,Image authentication issues have been raised due to the wide use of image manipulation software to obtain an illegitimate benefit or createmisleading publicity by using tempered images.Exiting forgery detectionmethods can classify only one of the most widely used Copy-Move and splicing forgeries.However,an image can contain one or more types of forgeries.This study has proposed a hybridmethod for classifying Copy-Move and splicing images using texture information of images in the spatial domain.Firstly,images are divided into equal blocks to get scale-invariant features.Weber law has been used for getting texture features,and finally,XGBOOST is used to classify both Copy-Move and splicing forgery.The proposed method classified three types of forgeries,i.e.,splicing,Copy-Move,and healthy.Benchmarked(CASIA 2.0,MICCF200)and RCMFD datasets are used for training and testing.On average,the proposed method achieved 97.3% accuracy on benchmarked datasets and 98.3% on RCMFD datasets by applying 10-fold cross-validation,which is far better than existing methods.
基金supported in part by the ZTE Industry-University-Institute Cooperation Funds.
文摘Weakly-coupled mode division multiplexing(MDM)technique is considered a promising candidate to enhance the capacity of an optical transmission system,in which mode multiplexers/demultiplexers(MMUX/MDEMUX)with low insertion loss and modal crosstalk are the key components.In this paper,a low-modal-crosstalk 4-mode MMUX/MDEMUX for the weakly-coupled triple-ring-core few-mode fiber(TRC-FMF)is designed and fabricated with side-polishing processing.The measurement results show that a pair of MMUX/MDEMUX and 25 km weakly-coupled TRC-FMF MDM link achieve low modal crosstalk of lower than−17.5 dB and insertion loss of lower than 11.56 dB for all the four modes.Based on the TRC-FMF and all-fiber MMUX/MDEMUX,an experiment for 25 km real-time 4-mode 3-λwavelength division multiplexing(WDM)-MDM transmission is conducted using commercial 400G optical transport network(OTN)transceivers.The experimental results prove weakly-coupled MDM techniques facilitate a smooth upgrade of the optical transmission system.
基金Project of Jiangsu Provincial Medical Talent,Grant/Award Number:ZDRCA2016033China Postdoctoral Science Foundation,Grant/Award Number:2018M640465+2 种基金National Natural Science Foundation of China,Grant/Award Numbers:81672295,81702265,81802277,81872378Research Program of Jiangsu Health Department,Grant/Award Number:LGY2016025Social Development Project of Jiangsu Province,Grant/Award Number:BE2019758。
文摘Background:Considering the increase in the proportion of lung adenocarcinoma(LUAD)cases among all lung cancers and its considerable contribution to cancer-related deaths worldwide,we sought to identify novel oncogenes to provide potential targets and facilitate a better understanding of the malignant progression of LUAD.Methods:The results from the screening of transcriptome and survival analyses according to the integrated Gene Expression Omnibus(GEO)datasets and The Cancer Genome Atlas(TCGA)data were combined,and a promising risk biomarker called meiotic nuclear divisions 1(MND1)was selectively acquired.Cell viability assays and subcutaneous xenograftmodelswere used to validate the oncogenic role ofMND1 in LUADcell proliferation and tumor growth.Aseries of assays,including mass spectrometry,co-immunoprecipitation(Co-IP),and chromatin immunoprecipitation(ChIP),were performed to explore the underlying mechanism.Results:MND1 up-regulation was identified to be an independent risk factor for overall survival in LUAD patients evaluated by both tissue microarray staining and third party data analysis.In vivo and in vitro assays showed that MND1 promoted LUAD cell proliferation by regulating cell cycle.The results of the Co-IP,ChIP and dual-luciferase reporter assays validated that MND1 competitively bound to tumor suppressor Kruppel-like factor 6(KLF6),and thereby protecting E2F transcription factor 1(E2F1)from KLF6-induced transcriptional repression.Luciferase reporter and ChIP assays found that E2F1 activated MND1 transcription by binding to its promoter in a feedback manner.Conclusions:MND1,KLF6,and E2F1 form a positive feedback loop to regulate cell cycle and confer DDP resistance in LUAD.MND1 is crucial for malignant progression and may be a potential therapeutic target in LUAD patients.
