Breast cancer is the second leading cancer in the world. <span style="font-family:Verdana;">The long-term</span><span style="font-family:Verdana;"> exposure </span><span ...Breast cancer is the second leading cancer in the world. <span style="font-family:Verdana;">The long-term</span><span style="font-family:Verdana;"> exposure </span><span style="font-family:Verdana;">of</span><span style="font-family:Verdana;"> some metallic compounds induces different forms of cancer, including breast cancer. Trace elements are essential metals for the physiological functions of the cell on a molecular level and also contribute </span><span style="font-family:Verdana;">in</span> <span style="font-family:Verdana;">treatment</span><span style="font-family:Verdana;"> of many diseases. </span><span style="font-family:Verdana;">The aim of study was</span><span style="font-family:Verdana;"> to compare the level of essential trace elements, sodium, potassium, calcium, iron, and zinc in breast cancer patients with normal healthy adult women. Total forty-five patients (age range from 25</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">-</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">73 years) were included in this study and divided into three groups according to three different stages of breast cancer including tumor-II, tumor-III </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> tumor-IV. Blood was collected from all participants after taking history, clinical data </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> taking consent. However, about fifteen non-cancer healthy women in </span><span style="font-family:Verdana;">age</span><span style="font-family:Verdana;"> range from 26</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">-</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">69 years were subjected to this study. The elemental concentrations were determined through atomic absorption spectrophotometer </span><span style="font-family:Verdana;">subsequent to</span><span style="font-family:Verdana;"> microwave-induced acid digestion. The results of Na, K, Zn, Fe, Ca, were observed </span></span><span style="font-family:Verdana;">to </span><span style="font-family:Verdana;">decrease in blood samples of breast cancer patients as compared to non-cancer subjects. The results are reliable with other numerous literature reported studies, the efficiency, and deficiency of these trace metals may contribute </span><span style="font-family:Verdana;">an </span><span style="font-family:Verdana;">important</span><span style="font-family:Verdana;"> role in the progress of breast cancer.</span>展开更多
September 2017 Contents Preface Ensuring People’s Right to Health Based on China’s Conditions Continuous Improvement of Health Environment and Conditions Public Health Service Capability Improving Steadily Great Imp...September 2017 Contents Preface Ensuring People’s Right to Health Based on China’s Conditions Continuous Improvement of Health Environment and Conditions Public Health Service Capability Improving Steadily Great Improvement in the Quality of Medical and Health Services Improvement of the National Medical Security展开更多
Workers of the Lakhra coal mining Sindh Pakistan were affected by a multi-factorial exposure of heavy metals. The prevalence of lead (Pb) exposures in work-related symptoms among workers of indoor and outdoor mining o...Workers of the Lakhra coal mining Sindh Pakistan were affected by a multi-factorial exposure of heavy metals. The prevalence of lead (Pb) exposures in work-related symptoms among workers of indoor and outdoor mining of Lakhra coal mining was evaluated in detail. The biological samples (scalp hair and blood) of 270 workers of Lakhra coal mining {official and control subjects} (indoor and outdoor) 18 to 55 years age group and 70 referent subjects of same age-groups were examined. The biological samples (blood and scalp hair) of workers of Lakhra coal mining and referent subjects were analyzed for calcium (Ca) and lead (Pb). Flame atomic absorption spectrometry was applied for the determination of the Ca in digested samples of studied subjects by the microwave oven whereas, the Pb contents were measured by electrothermal atomic absorption spectrometry. The validity of the methodology was checked by using the certified human hair material (BCR 397) and lyophilized human blood (Clincheck). The results indicated the higher contents of Pb in biological samples of indoor and outdoor mining workers than referents. However, the levels of Ca were found to be lower in indoor and outdoor mining workers than those of referents. It can be concluded that immediate action should be taken by recommended authorities to improve the ventilation and hygiene practices inside the industries, mines, and other workplaces.展开更多
Purpose: It is well known that trace elements and heavy metals play a significant role in human health and disease. These elements play an important role in different metabolic pathways of cells and tissues. Trace ele...Purpose: It is well known that trace elements and heavy metals play a significant role in human health and disease. These elements play an important role in different metabolic pathways of cells and tissues. Trace element deficiency or excess is implicated in the development or progression of some cancers. We present a study which investigates serum/ plasma levels of trace-heavy elements in metastatic colon cancer patients and healthy subjects. Methods: Blood samples were collected from 29 healthy subjects and 40 patients with metastatic colon cancer in Oncology Department of Medical School of Yuzuncu Yil University. In both groups, the serum levels of copper (Cu), magnesium (Mg), lead (Pb), chromium (Cr), zinc (Zn) selenium (Se), manganese (Mn), and cadmium (Cd) were determined. Results: Higher levels of Cu, Mg, Pb, Cr, Zn, Mn and Cd were seen in patients with metastatic colon cancer compared to healthy subjects and these findings were statistically significant (p 0.05). Se levels were noted to be lower in patients with colon cancer in comparison to healthy subjects and this finding was also statistically significant (p 0.05). Conclusions: According to our findings there was significant diffence in trace elements and heavy metals levels between healthy subjects and metastatic colon cancer patients. Therefore heavy metal and trace elements may have prognostic significance in complex disorders including colon cancer. However, further comprehensive studies are needed in order to advance our understanding of the relationship between heavy metal and trace elements and their role in cancers.展开更多
<strong>Background:</strong> Recently, Coronavirus Disease 2019 (COVID-19) has been affected by the extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has developed important global health a...<strong>Background:</strong> Recently, Coronavirus Disease 2019 (COVID-19) has been affected by the extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has developed important global health anxiety. At this time, the treatment options for this disease are only moderately successful. Smoking has been related to COVID-19 and its mortality, and it has the potential to affect bacteriological and viral conversion, clinical effects, and treatment outcomes. <strong>Methods:</strong> The aim of this study was to determine the relationship between critical essential trace {zinc (Zn), iron (Fe), and copper (Cu)} and toxic {cadmium (Cd) and nickel (Ni)} elements in human biological samples such as scalp hair, serum, saliva, blood, nasal fluid, and sputum of smoking and nonsmoking male COVID-19 patients (n = 139, age range 25 - 38 years) from Hyderabad, Pakistan. For comparative purposes, the biological specimens of referent persons (n = 83), pulmonary Tuberculosis (T.B) patients (n = 67), Pneumonia (n = 56) of the same age groups were also be analyzed. Microwave oven mediated digestion method was employed, and digestion of samples was carried out with the help of 2:1 mixture solution of HNO<sub>3</sub> (65%) and H<sub>2</sub>O<sub>2</sub> (30%). Atomic absorption spectrometry was employed for the determination of elemental concentrations from the microwave oven employed digested samples. <strong>Results:</strong> The found average of essential elements (Zn, Fe, and Cu) in biological specimens of smoker and nonsmoker male COVID-19, T.B, and Pneumonia patients was found to lower, whilst cadmium and nickel were found to be higher when compared with samples from referents (p < 0.001). <strong>Conclusions:</strong> Improved elemental (Cu, Fe, Zn) concentrations may also decrease the risk of bacterial co-infection by enhancing the mucociliary clearance and respiratory epithelial barrier function, in addition to providing direct antibacterial effects against <i>S. pneumoniae</i>. Our findings also suggest that higher Cd and Ni concentrations are linked to cigarette smoking, which could lead to COVID-19 and other lung-infected diseased recurrences. However, further clinical and experimental research is required.展开更多
文摘Breast cancer is the second leading cancer in the world. <span style="font-family:Verdana;">The long-term</span><span style="font-family:Verdana;"> exposure </span><span style="font-family:Verdana;">of</span><span style="font-family:Verdana;"> some metallic compounds induces different forms of cancer, including breast cancer. Trace elements are essential metals for the physiological functions of the cell on a molecular level and also contribute </span><span style="font-family:Verdana;">in</span> <span style="font-family:Verdana;">treatment</span><span style="font-family:Verdana;"> of many diseases. </span><span style="font-family:Verdana;">The aim of study was</span><span style="font-family:Verdana;"> to compare the level of essential trace elements, sodium, potassium, calcium, iron, and zinc in breast cancer patients with normal healthy adult women. Total forty-five patients (age range from 25</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">-</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">73 years) were included in this study and divided into three groups according to three different stages of breast cancer including tumor-II, tumor-III </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> tumor-IV. Blood was collected from all participants after taking history, clinical data </span><span style="font-family:Verdana;">and</span><span style="font-family:Verdana;"> taking consent. However, about fifteen non-cancer healthy women in </span><span style="font-family:Verdana;">age</span><span style="font-family:Verdana;"> range from 26</span></span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">-</span><span style="font-family:;" "=""> </span><span style="font-family:;" "=""><span style="font-family:Verdana;">69 years were subjected to this study. The elemental concentrations were determined through atomic absorption spectrophotometer </span><span style="font-family:Verdana;">subsequent to</span><span style="font-family:Verdana;"> microwave-induced acid digestion. The results of Na, K, Zn, Fe, Ca, were observed </span></span><span style="font-family:Verdana;">to </span><span style="font-family:Verdana;">decrease in blood samples of breast cancer patients as compared to non-cancer subjects. The results are reliable with other numerous literature reported studies, the efficiency, and deficiency of these trace metals may contribute </span><span style="font-family:Verdana;">an </span><span style="font-family:Verdana;">important</span><span style="font-family:Verdana;"> role in the progress of breast cancer.</span>
文摘September 2017 Contents Preface Ensuring People’s Right to Health Based on China’s Conditions Continuous Improvement of Health Environment and Conditions Public Health Service Capability Improving Steadily Great Improvement in the Quality of Medical and Health Services Improvement of the National Medical Security
文摘Workers of the Lakhra coal mining Sindh Pakistan were affected by a multi-factorial exposure of heavy metals. The prevalence of lead (Pb) exposures in work-related symptoms among workers of indoor and outdoor mining of Lakhra coal mining was evaluated in detail. The biological samples (scalp hair and blood) of 270 workers of Lakhra coal mining {official and control subjects} (indoor and outdoor) 18 to 55 years age group and 70 referent subjects of same age-groups were examined. The biological samples (blood and scalp hair) of workers of Lakhra coal mining and referent subjects were analyzed for calcium (Ca) and lead (Pb). Flame atomic absorption spectrometry was applied for the determination of the Ca in digested samples of studied subjects by the microwave oven whereas, the Pb contents were measured by electrothermal atomic absorption spectrometry. The validity of the methodology was checked by using the certified human hair material (BCR 397) and lyophilized human blood (Clincheck). The results indicated the higher contents of Pb in biological samples of indoor and outdoor mining workers than referents. However, the levels of Ca were found to be lower in indoor and outdoor mining workers than those of referents. It can be concluded that immediate action should be taken by recommended authorities to improve the ventilation and hygiene practices inside the industries, mines, and other workplaces.
文摘Purpose: It is well known that trace elements and heavy metals play a significant role in human health and disease. These elements play an important role in different metabolic pathways of cells and tissues. Trace element deficiency or excess is implicated in the development or progression of some cancers. We present a study which investigates serum/ plasma levels of trace-heavy elements in metastatic colon cancer patients and healthy subjects. Methods: Blood samples were collected from 29 healthy subjects and 40 patients with metastatic colon cancer in Oncology Department of Medical School of Yuzuncu Yil University. In both groups, the serum levels of copper (Cu), magnesium (Mg), lead (Pb), chromium (Cr), zinc (Zn) selenium (Se), manganese (Mn), and cadmium (Cd) were determined. Results: Higher levels of Cu, Mg, Pb, Cr, Zn, Mn and Cd were seen in patients with metastatic colon cancer compared to healthy subjects and these findings were statistically significant (p 0.05). Se levels were noted to be lower in patients with colon cancer in comparison to healthy subjects and this finding was also statistically significant (p 0.05). Conclusions: According to our findings there was significant diffence in trace elements and heavy metals levels between healthy subjects and metastatic colon cancer patients. Therefore heavy metal and trace elements may have prognostic significance in complex disorders including colon cancer. However, further comprehensive studies are needed in order to advance our understanding of the relationship between heavy metal and trace elements and their role in cancers.
文摘<strong>Background:</strong> Recently, Coronavirus Disease 2019 (COVID-19) has been affected by the extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has developed important global health anxiety. At this time, the treatment options for this disease are only moderately successful. Smoking has been related to COVID-19 and its mortality, and it has the potential to affect bacteriological and viral conversion, clinical effects, and treatment outcomes. <strong>Methods:</strong> The aim of this study was to determine the relationship between critical essential trace {zinc (Zn), iron (Fe), and copper (Cu)} and toxic {cadmium (Cd) and nickel (Ni)} elements in human biological samples such as scalp hair, serum, saliva, blood, nasal fluid, and sputum of smoking and nonsmoking male COVID-19 patients (n = 139, age range 25 - 38 years) from Hyderabad, Pakistan. For comparative purposes, the biological specimens of referent persons (n = 83), pulmonary Tuberculosis (T.B) patients (n = 67), Pneumonia (n = 56) of the same age groups were also be analyzed. Microwave oven mediated digestion method was employed, and digestion of samples was carried out with the help of 2:1 mixture solution of HNO<sub>3</sub> (65%) and H<sub>2</sub>O<sub>2</sub> (30%). Atomic absorption spectrometry was employed for the determination of elemental concentrations from the microwave oven employed digested samples. <strong>Results:</strong> The found average of essential elements (Zn, Fe, and Cu) in biological specimens of smoker and nonsmoker male COVID-19, T.B, and Pneumonia patients was found to lower, whilst cadmium and nickel were found to be higher when compared with samples from referents (p < 0.001). <strong>Conclusions:</strong> Improved elemental (Cu, Fe, Zn) concentrations may also decrease the risk of bacterial co-infection by enhancing the mucociliary clearance and respiratory epithelial barrier function, in addition to providing direct antibacterial effects against <i>S. pneumoniae</i>. Our findings also suggest that higher Cd and Ni concentrations are linked to cigarette smoking, which could lead to COVID-19 and other lung-infected diseased recurrences. However, further clinical and experimental research is required.
