In this work,the selected icebreaker model experiment is performed in a towing tank.We focus on the influence of seawater salinity on ship ice resistance in the ice floe field and the innovative ice model and ship mod...In this work,the selected icebreaker model experiment is performed in a towing tank.We focus on the influence of seawater salinity on ship ice resistance in the ice floe field and the innovative ice model and ship model test technology,including the similitude rule of ship model tests,test principles,and validation with full-scale ship data.A formula for calculating the relationship between the temperature and salinity of the water is constructed,which can be used to simulate the role of seawater in freshwater ice pools.On this basis,the effect of salinity on the resistance of ships sailing in broken ice fields is studied.A technique in which artificial ice made of polyethylene spheres is used to simulate ice resistance is proposed.With a series of ship model experiments in spherical and triangular ice fields,the effects of salinity and velocity on the ice resistance test of the ship model are analyzed.A relationship of the ice resistance of the ship model to the spherical ice field and the triangular ice field is proposed.The conversion results are consistent with onsite data of the full-size ship,which verifies the method of converting the test results of the ship model to the prototype.展开更多
Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor dysfunction.To date,no effective treatment exists as the exact causative mechanism rem...Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor dysfunction.To date,no effective treatment exists as the exact causative mechanism remains unknown.Therefore,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic targets.Since most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets astrocytes.These experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum disorders.In this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model choices.In addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.展开更多
This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer(GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment z...This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer(GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment zone.An experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs,and a calculation method based on the conjugate beam method was proposed.The composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab specimens.Two methods,epoxy resin bonding,and stud connection,were used to connect the composite slabs with the steel beams.The experimental findings showed that the specimen connected with epoxy resin exhibited two moments redistribution phenomena during the loading process:concrete cracking and steel bar yielding at the internal support.In contrast,the composite slab connected with steel beams by studs exhibited only one-moment redistribution phenomenon throughout the loading process.As the concrete at the internal support cracked,the bending moment decreased in the internal support section and increased in the midspan section.When the steel bars yielded,the bending moment further decreased in the internal support section and increased in the mid-span section.Since GFRP profiles do not experience cracking,there was no significant decrease in the bending moment of the mid-span section.All test specimens experienced compressive failure of concrete at the mid-span section.Calculation results showed good agreement between the calculated and experimental values of bending moments in the mid-span section and internal support section.The proposed model can effectively predict the moment redistribution behavior of continuous GFRP-concrete composite slabs.展开更多
Animal adaptation to environmental challenges is a complex process involving intricate interactions between the host genotype and gut microbiome composition.The gut microbiome,highly responsive to external environment...Animal adaptation to environmental challenges is a complex process involving intricate interactions between the host genotype and gut microbiome composition.The gut microbiome,highly responsive to external environmental factors,plays a crucial role in host adaptability and may facilitate local adaptation within species.Concurrently,the genetic background of host populations influences gut microbiome composition,highlighting the bidirectional relationship between host and microbiome.Despite this,our understanding of gut microbiome plasticity and its role in host adaptability remains limited,particularly in reptiles.To clarify this issue,we conducted a reciprocal translocation experiment with gravid females of the Qinghai toad-headed lizards(Phrynocephalus vlangalii)between high-altitude(2?600 m a.s.l.)and superhigh-altitude(3?600 m a.s.l.)environments on Dangjin Mountain of the Qinghai-Xizang Plateau,China.One year later,we assessed the phenotypes and gut microbiomes of their offspring.Results revealed significant plasticity in gut microbiome diversity and structure in response to contrasting elevations.Highaltitude conditions increased diversity,and maternal effects appeared to enable high-altitude lizards to maintain elevated diversity when exposed to superhigh-altitude environments.Additionally,superhigh-altitude lizards displayed distinct gut microbiome structures with notable host specificity,potentially linked to their lower growth rates.Overall,these findings underscore the importance of the gut microbiome in facilitating reptilian adaptation to rapid environmental changes across altitudinal gradients.Furthermore,this study provides critical insights into microbial mechanisms underpinning local adaptation and adaptative plasticity,offering a foundation for future research on host-microbiome interactions in evolutionary and ecological contexts.展开更多
The recent upsurge in metro construction emphasizes the necessity of understanding the mechanical performance of metro shield tunnel subjected to the influence of ground fissures.In this study,a largescale experiment,...The recent upsurge in metro construction emphasizes the necessity of understanding the mechanical performance of metro shield tunnel subjected to the influence of ground fissures.In this study,a largescale experiment,in combination with numerical simulation,was conducted to investigate the influence of ground fissures on a metro shield tunnel.The results indicate that the lining contact pressure at the vault increases in the hanging wall while decreases in the footwall,resulting in a two-dimensional stress state of vertical shear and axial tension-compression,and simultaneous vertical dislocation and axial tilt for the segments around the ground fissure.In addition,the damage to curved bolts includes tensile yield,flexural yield,and shear twist,leading to obvious concrete lining damage,particularly at the vault,arch bottom,and hance,indicating that the joints in these positions are weak areas.The shield tunnel orthogonal to the ground fissure ultimately experiences shear failure,suggesting that the maximum actual dislocation of ground fissure that the structure can withstand is approximately 20 cm,and five segment rings in the hanging wall and six segment rings in the footwall also need to be reinforced.This study could provide a reference for metro design in ground fissure sites.展开更多
A spice formulation study in Burkina Faso was carried out using local ingredients for the benefit of households. The objective of this study was to propose some spice formulations based on local ingredients in order t...A spice formulation study in Burkina Faso was carried out using local ingredients for the benefit of households. The objective of this study was to propose some spice formulations based on local ingredients in order to reduce the use of chemical spices in the preparation of different dishes. The Design of Experiments (DOE) methodology was used for the formulation of the spices and their physicochemical, nutritional and sensory characteristics were evaluated by standardized and standard methods. The results obtained showed lipid contents (g/100 g DM) ranging from 10.41 ± 0.26 to 15.64 ± 0.68, total sugars from 4.39 ± 0.32 to 5.46 ± 0.31, protein from 3.65 ± 0.17 to 12.04 ± 0.35 and ash from 5.83 ± 0.01 to 7.02 ± 0.01. The polyphenol content ranged from 9.09 ± 1.60 to 11.33 ± 0.90, and the flavonoid content ranged from 0.65 ± 0.03 to 1.08 ± 0.13. The sensory analysis carried out showed that the spices have generally satisfactory organoleptic characteristics. These results constitute new information in the diet of populations and are an alternative to the chemical spices used in their cooking.展开更多
Most of the existing studies on tunnel blast wave are based on spherical or grouped charges,however,conventional weapons are mostly cylindrical rather than spherical.In order to analyze the impact of cylindrical charg...Most of the existing studies on tunnel blast wave are based on spherical or grouped charges,however,conventional weapons are mostly cylindrical rather than spherical.In order to analyze the impact of cylindrical charges on the tunnel blast wave loads and to develop a quantitative calculation method,this study carried out experimental and numerical research.Initially,external explosion experiments were conducted using both 35 kg spherical charges and cylindrical charges with aspect ratio of 4.8 at two different distances from the tunnel entrance.Comparative analysis of the blast wave parameters in the tunnel revealed that the explosive equivalent of the cylindrical charges was significantly higher than that of the spherical charges.To address this,an equivalent coefficient k based on the spherical charges was proposed for the cylindrical charges.Subsequently,numerical simulations were conducted for the experimental conditions,and the numerical simulation results match the experiments well.Through numerical calculations,the reliability of the equivalent coefficient k under the experimental conditions was verified,and comparison analysis indicated that the explosion energy of cylindrical charges spreads more radially,resulting in more explosion energy entering the tunnel,which is the fundamental reason for the increase in tunnel blast wave loads.Additionally,analyzing the explosion energy ratio entering the tunnel is an effective method for calculating the equivalent coefficient k.Finally,through more than one hundred sets of numerical calculation results,the impact of the proportional distance l and the ratio of charge mass to the tunnel cross-section dimension 4 on the equivalence coefficients k was investigated.An empirical formula for the equivalence coefficient k was derived through fitting,and the accuracy of the formula was validated through literature experimental results.The research findings of this paper will provide valuable guidance for the calculation of blast wave loads in tunnel.展开更多
In this study,the hydraulic behavior and sand transport efficiency of the siphon automatic sand discharge device were studied by software simulation tests.By simulating the actual situation,this study analyzed how fac...In this study,the hydraulic behavior and sand transport efficiency of the siphon automatic sand discharge device were studied by software simulation tests.By simulating the actual situation,this study analyzed how factors such as the difference in water level,sediment concentration,and pipeline layout affected the sediment discharge effect.The results show that the sediment discharge device can effectively discharge sediment under diverse operating conditions and show adaptability to different environmental conditions,which indicates that it is suitable for various types of reservoir environments.展开更多
The construction of the New Medical Sciences aims to cultivate interdisciplinary medical talents,placing higher demands on physiology experiment teaching.In light of the challenges of traditional teaching,such as outd...The construction of the New Medical Sciences aims to cultivate interdisciplinary medical talents,placing higher demands on physiology experiment teaching.In light of the challenges of traditional teaching,such as outdated content,a single assessment mechanism,low student engagement,and limited research experience among instructors,this study proposes a reform pathway centered on research competence development,supported by diversified evaluation methods and the deep integration of ideological and scenario-based teaching.By optimizing teaching content,introducing innovative projects,establishing a multidimensional assessment system,and strengthening faculty development,the proposed reforms effectively enhance students’Innovative ability and practical skills.This study provides theoretical insights and practical experience for training interdisciplinary medical professionals to meet the demands of the new era.展开更多
In comparison with conventional experimental teaching methods,the implementation of the Motic digital microscope mutual system in the experimental teaching of medicinal botany has been demonstrated to be a highly effi...In comparison with conventional experimental teaching methods,the implementation of the Motic digital microscope mutual system in the experimental teaching of medicinal botany has been demonstrated to be a highly efficacious approach to enhance the teaching level of experimental courses in medicinal botany.The implementation of a digital microscope mutual system in experimental teaching not only enhances students practical skills in laboratory operations but also increases classroom efficiency.Furthermore,it supports personalized development among students while fostering innovative thinking,independent learning capabilities,and analysis and problem-solving skills.Additionally,this approach contributes to the enhancement of students scientific literacy.展开更多
Cardiac injury initiates repair mechanisms and results in cardiac remodeling and fi-brosis,which appears to be a leading cause of cardiovascular diseases.Cardiac fi-brosis is characterized by the accumulation of extra...Cardiac injury initiates repair mechanisms and results in cardiac remodeling and fi-brosis,which appears to be a leading cause of cardiovascular diseases.Cardiac fi-brosis is characterized by the accumulation of extracellular matrix proteins,mainly collagen in the cardiac interstitium.Many experimental studies have demonstrated that fibrotic injury in the heart is reversible;therefore,it is vital to understand differ-ent molecular mechanisms that are involved in the initiation,progression,and resolu-tion of cardiac fibrosis to enable the development of antifibrotic agents.Of the many experimental models,one of the recent models that has gained renewed interest is isoproterenol(ISP)-induced cardiac fibrosis.ISP is a synthetic catecholamine,sympa-thomimetic,and nonselectiveβ-adrenergic receptor agonist.The overstimulated and sustained activation ofβ-adrenergic receptors has been reported to induce biochemi-cal and physiological alterations and ultimately result in cardiac remodeling.ISP has been used for decades to induce acute myocardial infarction.However,the use of low doses and chronic administration of ISP have been shown to induce cardiac fibrosis;this practice has increased in recent years.Intraperitoneal or subcutaneous ISP has been widely used in preclinical studies to induce cardiac remodeling manifested by fibrosis and hypertrophy.The induced oxidative stress with subsequent perturbations in cellular signaling cascades through triggering the release of free radicals is consid-ered the initiating mechanism of myocardial fibrosis.ISP is consistently used to induce fibrosis in laboratory animals and in cardiomyocytes isolated from animals.In recent years,numerous phytochemicals and synthetic molecules have been evaluated in ISP-induced cardiac fibrosis.The present review exclusively provides a comprehensive summary of the pathological biochemical,histological,and molecular mechanisms of ISP in inducing cardiac fibrosis and hypertrophy.It also summarizes the application of this experimental model in the therapeutic evaluation of natural as well as syn-thetic compounds to demonstrate their potential in mitigating myocardial fibrosis and hypertrophy.展开更多
Floating breakwaters(FBs)are commonly employed for the protection of coastal installations.In this work,a convextype floating breakwater(FB)is proposed,and its hydrodynamic characteristics are studied through systemat...Floating breakwaters(FBs)are commonly employed for the protection of coastal installations.In this work,a convextype floating breakwater(FB)is proposed,and its hydrodynamic characteristics are studied through systematic laboratory experiments.Two different deck widths and two different mooring systems are set in the experiment.The transmission coefficients,reflection coefficients,motion responses and mooring forces of convex-type FBs are obtained in experiments.The influences of the deck width and mooring system on the hydrodynamic characteristics of the proposed FB are analyzed and compared.The experimental results show that the reflection coefficient and mooring force of the convex-type FB with a cross-mooring system are significantly larger than those of the convextype FB with a parallel-mooring system.A convex-type FB with a larger deck width has a higher reflection coefficient.The convex-type FBs with cross-and parallel-mooring systems have similar surge and heave motions,but the cross-mooring results in small roll motion.In addition,reliable prediction formulas for the transmission coefficient of convex-type FBs with different mooring systems have been developed,which are important for engineering design.展开更多
This paper proposes a modification of the Forrestal-Warren perforation model aimed at extending its applicability range to intermediately-thick high-hardness armor steel plates.When impacted by armorpiercing projectil...This paper proposes a modification of the Forrestal-Warren perforation model aimed at extending its applicability range to intermediately-thick high-hardness armor steel plates.When impacted by armorpiercing projectiles,these plates tend to fail through adiabatic shear plugging which significantly reduces their ballistic resistance.To address this effect,an approach for determining effective thickness was defined and incorporated into the predictive model.Ballistic impact tests were performed to assess the modification's validity,in which ARMOX 500T steel plates were subjected to perpendicular impacts from 7.62×39 mm steel-cored rounds under various velocities.Frequent target failure by soft plugging was observed,as well as the brittle shatter of the hard steel core.Key properties of the recovered plugs including their mass,length and diameter were measured and reported along with the projectiles'residual velocities.Additionally,independent data from the open literature were included in the analysis for further validation.The original Forrestal-Warren model and the novel effective thickness modification were then used to establish the relationship between impact and residual velocities,as well as to determine the ballistic limit velocity.The comparison revealed that the proposed approach significantly improves the model's accuracy,showing a strong correlation with experimental data and reducing deviations to within a few percent.This enhancement highlights the potential of the effective thickness term,which could also be applied to other predictive models to extend their applicability range.Further exploration into other armor steels and impact conditions is recommended to assess the method's versatility.展开更多
Objective:To screen and identify the key active molecules,signaling pathways,and therapeutic targets of Shuxuening(SXN)injection for treating liver cirrhosis(LC)and to evaluate its therapeutic potential using a mouse ...Objective:To screen and identify the key active molecules,signaling pathways,and therapeutic targets of Shuxuening(SXN)injection for treating liver cirrhosis(LC)and to evaluate its therapeutic potential using a mouse model.Methods:Target genes of SXN and LC were retrieved from public databases,and enrichment analysis was performed.A proteineprotein interaction(PPI)network was constructed using the Search Tool for the Retrieval of Interacting Genes/Proteins(STRING),and hub genes were identified using Molecular Complex Detection(MCODE).LC was induced in rats and mice via intraperitoneal injections of diethylnitrosamine and carbon tetrachloride(CCl4)for 12 weeks.Starting at week 7,SXN was administered intraperitoneally to the mice in the treatment group.Serum and liver tissues of the mice were collected for the detection of indicators,pathological staining,and expression analysis of hub targets using quantitative real-time polymerase chain reaction(qRT-PCR).Results:We identified 368 overlapping genes(OLGs)between SXN and LC targets.These OLGs were subsequently used to build a PPI network and to screen for hub genes.Enrichment analysis showed that these genes were associated with cancer-related pathways,including phosphoinositide-3-kinase/Akt and mitogen-activated protein kinase signaling and various cellular processes,such as responses to chemicals and metabolic regulation.In vivo experiments demonstrated that SXN treatment significantly improved liver function and pathology in CCl4-induced LC mice by reducing inflammation and collagen deposition.Furthermore,qRT-PCR demonstrated that SXN regulated the expression of MAPK8,AR and CASP3 in the livers of LC mice.Conclusion:This study highlighted the therapeutic effects of SXN in alleviating LC using both bioinformatics and experimental methods.The observed effect was associated with modulation of hub gene expression,particularly MAPK8,and CASP3.展开更多
Viruses, notably airborne viruses, are difficult to collect and detect because of the low concentrations of environmental microorganisms. Bacteriophages are frequently used in air experiments as suitable surrogates fo...Viruses, notably airborne viruses, are difficult to collect and detect because of the low concentrations of environmental microorganisms. Bacteriophages are frequently used in air experiments as suitable surrogates for human and animal viruses^([1]). Bacteriophages are non-pathogenic, so they are safe for laboratory workers and do not require specialized biological protection measures.Bacteriophages can be prepared at high titers using simple and low-cost methods.展开更多
In the scenario of a steam generator tube rupture accident in a lead-cooled fast reactor,secondary circuit subcooled water under high pressure is injected into an ordinary-pressure primary vessel,where a molten lead-b...In the scenario of a steam generator tube rupture accident in a lead-cooled fast reactor,secondary circuit subcooled water under high pressure is injected into an ordinary-pressure primary vessel,where a molten lead-based alloy(typically pure lead or lead-bismuth eutectic(LBE))is used as the coolant.To clarify the pressure build-up characteristics under water-jet injection,this study conducted several experiments by injecting pressurized water into a molten LBE pool at Sun Yat-sen University.To obtain a further understanding,several new experimental parameters were adopted,including the melt temperature,water subcooling,injection pressure,injection duration,and nozzle diameter.Through detailed analyses,it was found that the pressure and temperature during the water-melt interaction exhibited a consistent variation trend with our previous water-droplet injection mode LBE experiment.Similarly,the existence of a steam explosion was confirmed,which typically results in a much stronger pressure build-up.For the non-explosion cases,increasing the injection pressure,melt-pool temperature,nozzle diameter,and water subcooling promoted pressure build-up in the melt pool.However,a limited enhancement effect was observed when increasing the injection duration,which may be owing to the continually rising pressure in the interaction vessel or the isolation effect of the generated steam cavity.Regardless of whether a steam explosion occurred,the calculated mechanical and kinetic energy conversion efficiencies of the melt were relatively small(not exceeding 4.1%and 0.7%,respectively).Moreover,the range of the conversion efficiency was similar to that of previous water-droplet experiments,although the upper limit of the jet mode was slightly lower.展开更多
Powered by advanced information technology,more and more complex systems are exhibiting characteristics of the cyber-physical-social systems(CPSS).In this context,computational experiments method has emerged as a nove...Powered by advanced information technology,more and more complex systems are exhibiting characteristics of the cyber-physical-social systems(CPSS).In this context,computational experiments method has emerged as a novel approach for the design,analysis,management,control,and integration of CPSS,which can realize the causal analysis of complex systems by means of“algorithmization”of“counterfactuals”.However,because CPSS involve human and social factors(e.g.,autonomy,initiative,and sociality),it is difficult for traditional design of experiment(DOE)methods to achieve the generative explanation of system emergence.To address this challenge,this paper proposes an integrated approach to the design of computational experiments,incorporating three key modules:1)Descriptive module:Determining the influencing factors and response variables of the system by means of the modeling of an artificial society;2)Interpretative module:Selecting factorial experimental design solution to identify the relationship between influencing factors and macro phenomena;3)Predictive module:Building a meta-model that is equivalent to artificial society to explore its operating laws.Finally,a case study of crowd-sourcing platforms is presented to illustrate the application process and effectiveness of the proposed approach,which can reveal the social impact of algorithmic behavior on“rider race”.展开更多
Fishing boats are usually anchored side by side in the harbor because of the small structural size and poor resistance to wind and waves.A series of physical model experiments are conducted to investigate the motion c...Fishing boats are usually anchored side by side in the harbor because of the small structural size and poor resistance to wind and waves.A series of physical model experiments are conducted to investigate the motion characteristics of multiple fishing boats that are moored together.A decay test in calm water is conducted to study the natural period and damping coefficients.Regular wave experiments are performed to analyze the roll motion response of each boat for four modes(different numbers of boats side-by-side).The results indicate that the“natural period”of each boat for the mode of multi-boats especially three or four boats,is slightly smaller than that of a single boat,whereas the damping coefficient is visibly larger than that of a single boat.The maximum roll angle of each boat does not appear at the same time under a 90°incident wave.Small roll motion energy is generated at low frequencies and high frequencies when multiple boats are moored together.The energy decreases with the increasing wave period.The roll motion responses of each boat in four modes exhibit different trends with the increasing wave frequency.The number of boats and boat position have significant effects on roll motion.展开更多
In recent years,rockburst have gained significant attention as a crucial topic in rock engineering.Strain andfault-slip rockburst are two common types that occur frequently and cause substantial damage.The objective o...In recent years,rockburst have gained significant attention as a crucial topic in rock engineering.Strain andfault-slip rockburst are two common types that occur frequently and cause substantial damage.The objective of thisreview is to conduct a comprehensive study on the experiments and failure mechanisms of strain and fault-slip rockburst.Firstly,the article analyzes the evolving trends in experimental research on rockburst in the past decade,highlightingmechanical properties and failure modes as the primary research focuses in understanding rockburst mechanisms.Subsequently,it provides an overview of the experimental techniques and methods employed for studying both types ofrockburst.Then,with a focus on the mechanical properties and failure modes,the article conducts an extensive analysisof the failure mechanisms associated with strain and fault-slip rockburst.By analyzing experimental data and observingthe failure characteristics of samples,it discusses the variations and common features exhibited by these two types ofrockburst under various test conditions.This analysis is of paramount importance in revealing the causes of rockburstformation and development,as well as in predicting rockburst trends and assessing associated risks.Lastly,thelimitations of current rockburst experiments and future research directions are discussed,followed by a comprehensivesummary of the entire article.展开更多
Accurate prediction of future rice yield needs the precise estimations of rice yield response to climate change factors,of which the most important one is the increasing carbon dioxide(CO_(2))concentrations.Estimates ...Accurate prediction of future rice yield needs the precise estimations of rice yield response to climate change factors,of which the most important one is the increasing carbon dioxide(CO_(2))concentrations.Estimates of CO_(2) fertilization effect(CFE)on rice,however,still had large uncertainties.Therefore,using the rice planting areas in East China as the study area,we firstly compared the rice yields and CFE predicted by four state-of-the-art crop models,and found that the CFE predicted by these models had significant differences.We then quantified the CFE on rice yield using the field-controlled experiment conducted at Danyang site at Jiangsu province.Using CFE measurements from a field experiment as benchmark,we have developed an experiment–model integration approach aiming to reduce this variation.This study thus highlights the large CFE uncertainties of current crop models and provides us with a method to reduce this uncertainty,which is beneficial for the accurate prediction of future global rice yield in the context of climate change.展开更多
基金financially supported by Jiangsu Province University(High Tech Ship)Collaborative Innovation Center(Grant No.XTCXKY20230008).
文摘In this work,the selected icebreaker model experiment is performed in a towing tank.We focus on the influence of seawater salinity on ship ice resistance in the ice floe field and the innovative ice model and ship model test technology,including the similitude rule of ship model tests,test principles,and validation with full-scale ship data.A formula for calculating the relationship between the temperature and salinity of the water is constructed,which can be used to simulate the role of seawater in freshwater ice pools.On this basis,the effect of salinity on the resistance of ships sailing in broken ice fields is studied.A technique in which artificial ice made of polyethylene spheres is used to simulate ice resistance is proposed.With a series of ship model experiments in spherical and triangular ice fields,the effects of salinity and velocity on the ice resistance test of the ship model are analyzed.A relationship of the ice resistance of the ship model to the spherical ice field and the triangular ice field is proposed.The conversion results are consistent with onsite data of the full-size ship,which verifies the method of converting the test results of the ship model to the prototype.
文摘Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor dysfunction.To date,no effective treatment exists as the exact causative mechanism remains unknown.Therefore,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic targets.Since most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets astrocytes.These experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum disorders.In this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model choices.In addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.
基金supported by National Natural Science Foundation of China(Project No.51878156,received by Wen-Wei Wang) and EPC Innovation Consulting Project for Longkou Nanshan LNG Phase I Receiving Terminal(Z2000LGENT0399,received by Wen-Wei Wang and ZhaoJun Zhang).
文摘This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer(GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment zone.An experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs,and a calculation method based on the conjugate beam method was proposed.The composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab specimens.Two methods,epoxy resin bonding,and stud connection,were used to connect the composite slabs with the steel beams.The experimental findings showed that the specimen connected with epoxy resin exhibited two moments redistribution phenomena during the loading process:concrete cracking and steel bar yielding at the internal support.In contrast,the composite slab connected with steel beams by studs exhibited only one-moment redistribution phenomenon throughout the loading process.As the concrete at the internal support cracked,the bending moment decreased in the internal support section and increased in the midspan section.When the steel bars yielded,the bending moment further decreased in the internal support section and increased in the mid-span section.Since GFRP profiles do not experience cracking,there was no significant decrease in the bending moment of the mid-span section.All test specimens experienced compressive failure of concrete at the mid-span section.Calculation results showed good agreement between the calculated and experimental values of bending moments in the mid-span section and internal support section.The proposed model can effectively predict the moment redistribution behavior of continuous GFRP-concrete composite slabs.
基金supported by the National Natural Science Foundation of China (31861143023,31872252)Strategic Priority Research Program of the Chinese Academy of Sciences (XDA20050201)。
文摘Animal adaptation to environmental challenges is a complex process involving intricate interactions between the host genotype and gut microbiome composition.The gut microbiome,highly responsive to external environmental factors,plays a crucial role in host adaptability and may facilitate local adaptation within species.Concurrently,the genetic background of host populations influences gut microbiome composition,highlighting the bidirectional relationship between host and microbiome.Despite this,our understanding of gut microbiome plasticity and its role in host adaptability remains limited,particularly in reptiles.To clarify this issue,we conducted a reciprocal translocation experiment with gravid females of the Qinghai toad-headed lizards(Phrynocephalus vlangalii)between high-altitude(2?600 m a.s.l.)and superhigh-altitude(3?600 m a.s.l.)environments on Dangjin Mountain of the Qinghai-Xizang Plateau,China.One year later,we assessed the phenotypes and gut microbiomes of their offspring.Results revealed significant plasticity in gut microbiome diversity and structure in response to contrasting elevations.Highaltitude conditions increased diversity,and maternal effects appeared to enable high-altitude lizards to maintain elevated diversity when exposed to superhigh-altitude environments.Additionally,superhigh-altitude lizards displayed distinct gut microbiome structures with notable host specificity,potentially linked to their lower growth rates.Overall,these findings underscore the importance of the gut microbiome in facilitating reptilian adaptation to rapid environmental changes across altitudinal gradients.Furthermore,this study provides critical insights into microbial mechanisms underpinning local adaptation and adaptative plasticity,offering a foundation for future research on host-microbiome interactions in evolutionary and ecological contexts.
基金supported by the National Key Research&Development Program of China(Grant No.2023YFC3008404)the Key Laboratory of Earth Fissures Geological Disaster,Ministry of Natural Resources,China(Grant Nos.EFGD20240609 and EFGD20240610).
文摘The recent upsurge in metro construction emphasizes the necessity of understanding the mechanical performance of metro shield tunnel subjected to the influence of ground fissures.In this study,a largescale experiment,in combination with numerical simulation,was conducted to investigate the influence of ground fissures on a metro shield tunnel.The results indicate that the lining contact pressure at the vault increases in the hanging wall while decreases in the footwall,resulting in a two-dimensional stress state of vertical shear and axial tension-compression,and simultaneous vertical dislocation and axial tilt for the segments around the ground fissure.In addition,the damage to curved bolts includes tensile yield,flexural yield,and shear twist,leading to obvious concrete lining damage,particularly at the vault,arch bottom,and hance,indicating that the joints in these positions are weak areas.The shield tunnel orthogonal to the ground fissure ultimately experiences shear failure,suggesting that the maximum actual dislocation of ground fissure that the structure can withstand is approximately 20 cm,and five segment rings in the hanging wall and six segment rings in the footwall also need to be reinforced.This study could provide a reference for metro design in ground fissure sites.
文摘A spice formulation study in Burkina Faso was carried out using local ingredients for the benefit of households. The objective of this study was to propose some spice formulations based on local ingredients in order to reduce the use of chemical spices in the preparation of different dishes. The Design of Experiments (DOE) methodology was used for the formulation of the spices and their physicochemical, nutritional and sensory characteristics were evaluated by standardized and standard methods. The results obtained showed lipid contents (g/100 g DM) ranging from 10.41 ± 0.26 to 15.64 ± 0.68, total sugars from 4.39 ± 0.32 to 5.46 ± 0.31, protein from 3.65 ± 0.17 to 12.04 ± 0.35 and ash from 5.83 ± 0.01 to 7.02 ± 0.01. The polyphenol content ranged from 9.09 ± 1.60 to 11.33 ± 0.90, and the flavonoid content ranged from 0.65 ± 0.03 to 1.08 ± 0.13. The sensory analysis carried out showed that the spices have generally satisfactory organoleptic characteristics. These results constitute new information in the diet of populations and are an alternative to the chemical spices used in their cooking.
文摘Most of the existing studies on tunnel blast wave are based on spherical or grouped charges,however,conventional weapons are mostly cylindrical rather than spherical.In order to analyze the impact of cylindrical charges on the tunnel blast wave loads and to develop a quantitative calculation method,this study carried out experimental and numerical research.Initially,external explosion experiments were conducted using both 35 kg spherical charges and cylindrical charges with aspect ratio of 4.8 at two different distances from the tunnel entrance.Comparative analysis of the blast wave parameters in the tunnel revealed that the explosive equivalent of the cylindrical charges was significantly higher than that of the spherical charges.To address this,an equivalent coefficient k based on the spherical charges was proposed for the cylindrical charges.Subsequently,numerical simulations were conducted for the experimental conditions,and the numerical simulation results match the experiments well.Through numerical calculations,the reliability of the equivalent coefficient k under the experimental conditions was verified,and comparison analysis indicated that the explosion energy of cylindrical charges spreads more radially,resulting in more explosion energy entering the tunnel,which is the fundamental reason for the increase in tunnel blast wave loads.Additionally,analyzing the explosion energy ratio entering the tunnel is an effective method for calculating the equivalent coefficient k.Finally,through more than one hundred sets of numerical calculation results,the impact of the proportional distance l and the ratio of charge mass to the tunnel cross-section dimension 4 on the equivalence coefficients k was investigated.An empirical formula for the equivalence coefficient k was derived through fitting,and the accuracy of the formula was validated through literature experimental results.The research findings of this paper will provide valuable guidance for the calculation of blast wave loads in tunnel.
基金Supported by the National Undergraduate Innovation Training Program(Project No.202211437036).
文摘In this study,the hydraulic behavior and sand transport efficiency of the siphon automatic sand discharge device were studied by software simulation tests.By simulating the actual situation,this study analyzed how factors such as the difference in water level,sediment concentration,and pipeline layout affected the sediment discharge effect.The results show that the sediment discharge device can effectively discharge sediment under diverse operating conditions and show adaptability to different environmental conditions,which indicates that it is suitable for various types of reservoir environments.
基金supported by the Key Teaching Reform and Practice Project of Pingdingshan University in 2023,titled“Research and Practice on Innovation and Entrepreneurship Pathways for Medical Students under the New Medical Discipline Framework”(Project No.2023-JYZD15)Additionally,this study received support from the Henan Province Higher Education Teaching Reform Research and Practice Project,titled“Research on the Integration Path of Medical Education and Innovation&Entrepreneurship Education under the‘Project-based+Mentorship System’Model”(Project No.2024SJGLX0495).
文摘The construction of the New Medical Sciences aims to cultivate interdisciplinary medical talents,placing higher demands on physiology experiment teaching.In light of the challenges of traditional teaching,such as outdated content,a single assessment mechanism,low student engagement,and limited research experience among instructors,this study proposes a reform pathway centered on research competence development,supported by diversified evaluation methods and the deep integration of ideological and scenario-based teaching.By optimizing teaching content,introducing innovative projects,establishing a multidimensional assessment system,and strengthening faculty development,the proposed reforms effectively enhance students’Innovative ability and practical skills.This study provides theoretical insights and practical experience for training interdisciplinary medical professionals to meet the demands of the new era.
基金Supported by Major Project of School-level Teaching Reform and Research of Guangxi University of Chinese Medicine(2022A006)。
文摘In comparison with conventional experimental teaching methods,the implementation of the Motic digital microscope mutual system in the experimental teaching of medicinal botany has been demonstrated to be a highly efficacious approach to enhance the teaching level of experimental courses in medicinal botany.The implementation of a digital microscope mutual system in experimental teaching not only enhances students practical skills in laboratory operations but also increases classroom efficiency.Furthermore,it supports personalized development among students while fostering innovative thinking,independent learning capabilities,and analysis and problem-solving skills.Additionally,this approach contributes to the enhancement of students scientific literacy.
基金United Arab Emirates University,Grant/Award Number:12R104 and 12R121。
文摘Cardiac injury initiates repair mechanisms and results in cardiac remodeling and fi-brosis,which appears to be a leading cause of cardiovascular diseases.Cardiac fi-brosis is characterized by the accumulation of extracellular matrix proteins,mainly collagen in the cardiac interstitium.Many experimental studies have demonstrated that fibrotic injury in the heart is reversible;therefore,it is vital to understand differ-ent molecular mechanisms that are involved in the initiation,progression,and resolu-tion of cardiac fibrosis to enable the development of antifibrotic agents.Of the many experimental models,one of the recent models that has gained renewed interest is isoproterenol(ISP)-induced cardiac fibrosis.ISP is a synthetic catecholamine,sympa-thomimetic,and nonselectiveβ-adrenergic receptor agonist.The overstimulated and sustained activation ofβ-adrenergic receptors has been reported to induce biochemi-cal and physiological alterations and ultimately result in cardiac remodeling.ISP has been used for decades to induce acute myocardial infarction.However,the use of low doses and chronic administration of ISP have been shown to induce cardiac fibrosis;this practice has increased in recent years.Intraperitoneal or subcutaneous ISP has been widely used in preclinical studies to induce cardiac remodeling manifested by fibrosis and hypertrophy.The induced oxidative stress with subsequent perturbations in cellular signaling cascades through triggering the release of free radicals is consid-ered the initiating mechanism of myocardial fibrosis.ISP is consistently used to induce fibrosis in laboratory animals and in cardiomyocytes isolated from animals.In recent years,numerous phytochemicals and synthetic molecules have been evaluated in ISP-induced cardiac fibrosis.The present review exclusively provides a comprehensive summary of the pathological biochemical,histological,and molecular mechanisms of ISP in inducing cardiac fibrosis and hypertrophy.It also summarizes the application of this experimental model in the therapeutic evaluation of natural as well as syn-thetic compounds to demonstrate their potential in mitigating myocardial fibrosis and hypertrophy.
基金financially supported by the National Natural Science Foundation of China(Grant No.52088102)New Cornerstone Science Foundation through the XPLORER PRIZE.
文摘Floating breakwaters(FBs)are commonly employed for the protection of coastal installations.In this work,a convextype floating breakwater(FB)is proposed,and its hydrodynamic characteristics are studied through systematic laboratory experiments.Two different deck widths and two different mooring systems are set in the experiment.The transmission coefficients,reflection coefficients,motion responses and mooring forces of convex-type FBs are obtained in experiments.The influences of the deck width and mooring system on the hydrodynamic characteristics of the proposed FB are analyzed and compared.The experimental results show that the reflection coefficient and mooring force of the convex-type FB with a cross-mooring system are significantly larger than those of the convextype FB with a parallel-mooring system.A convex-type FB with a larger deck width has a higher reflection coefficient.The convex-type FBs with cross-and parallel-mooring systems have similar surge and heave motions,but the cross-mooring results in small roll motion.In addition,reliable prediction formulas for the transmission coefficient of convex-type FBs with different mooring systems have been developed,which are important for engineering design.
基金supported by the Ministry of Science,Technological Development and Innovation of the Republic of Serbia,through the Contract no.451-03-65/2024e03/200105.
文摘This paper proposes a modification of the Forrestal-Warren perforation model aimed at extending its applicability range to intermediately-thick high-hardness armor steel plates.When impacted by armorpiercing projectiles,these plates tend to fail through adiabatic shear plugging which significantly reduces their ballistic resistance.To address this effect,an approach for determining effective thickness was defined and incorporated into the predictive model.Ballistic impact tests were performed to assess the modification's validity,in which ARMOX 500T steel plates were subjected to perpendicular impacts from 7.62×39 mm steel-cored rounds under various velocities.Frequent target failure by soft plugging was observed,as well as the brittle shatter of the hard steel core.Key properties of the recovered plugs including their mass,length and diameter were measured and reported along with the projectiles'residual velocities.Additionally,independent data from the open literature were included in the analysis for further validation.The original Forrestal-Warren model and the novel effective thickness modification were then used to establish the relationship between impact and residual velocities,as well as to determine the ballistic limit velocity.The comparison revealed that the proposed approach significantly improves the model's accuracy,showing a strong correlation with experimental data and reducing deviations to within a few percent.This enhancement highlights the potential of the effective thickness term,which could also be applied to other predictive models to extend their applicability range.Further exploration into other armor steels and impact conditions is recommended to assess the method's versatility.
基金Our study was funded by the Clinical Research Special Fund of Wu Jieping Medical Foundation(320.6750.2022-25-8)the Fundamental Research Funds for the Cornell University(2024-JYBXJSJJ042 and 2024-JYB-JBZD-058).
文摘Objective:To screen and identify the key active molecules,signaling pathways,and therapeutic targets of Shuxuening(SXN)injection for treating liver cirrhosis(LC)and to evaluate its therapeutic potential using a mouse model.Methods:Target genes of SXN and LC were retrieved from public databases,and enrichment analysis was performed.A proteineprotein interaction(PPI)network was constructed using the Search Tool for the Retrieval of Interacting Genes/Proteins(STRING),and hub genes were identified using Molecular Complex Detection(MCODE).LC was induced in rats and mice via intraperitoneal injections of diethylnitrosamine and carbon tetrachloride(CCl4)for 12 weeks.Starting at week 7,SXN was administered intraperitoneally to the mice in the treatment group.Serum and liver tissues of the mice were collected for the detection of indicators,pathological staining,and expression analysis of hub targets using quantitative real-time polymerase chain reaction(qRT-PCR).Results:We identified 368 overlapping genes(OLGs)between SXN and LC targets.These OLGs were subsequently used to build a PPI network and to screen for hub genes.Enrichment analysis showed that these genes were associated with cancer-related pathways,including phosphoinositide-3-kinase/Akt and mitogen-activated protein kinase signaling and various cellular processes,such as responses to chemicals and metabolic regulation.In vivo experiments demonstrated that SXN treatment significantly improved liver function and pathology in CCl4-induced LC mice by reducing inflammation and collagen deposition.Furthermore,qRT-PCR demonstrated that SXN regulated the expression of MAPK8,AR and CASP3 in the livers of LC mice.Conclusion:This study highlighted the therapeutic effects of SXN in alleviating LC using both bioinformatics and experimental methods.The observed effect was associated with modulation of hub gene expression,particularly MAPK8,and CASP3.
基金supported by Capital health development research project(Grant No.2022-2G-4232)。
文摘Viruses, notably airborne viruses, are difficult to collect and detect because of the low concentrations of environmental microorganisms. Bacteriophages are frequently used in air experiments as suitable surrogates for human and animal viruses^([1]). Bacteriophages are non-pathogenic, so they are safe for laboratory workers and do not require specialized biological protection measures.Bacteriophages can be prepared at high titers using simple and low-cost methods.
基金supported by Basic and Applied Basic research foundation of Guangdong province(Nos.2021A1515010343 and 2022A1515011582)the Science and Technology Program of Guangdong Province(Nos.2021A0505030026 and 2022A0505050029).
文摘In the scenario of a steam generator tube rupture accident in a lead-cooled fast reactor,secondary circuit subcooled water under high pressure is injected into an ordinary-pressure primary vessel,where a molten lead-based alloy(typically pure lead or lead-bismuth eutectic(LBE))is used as the coolant.To clarify the pressure build-up characteristics under water-jet injection,this study conducted several experiments by injecting pressurized water into a molten LBE pool at Sun Yat-sen University.To obtain a further understanding,several new experimental parameters were adopted,including the melt temperature,water subcooling,injection pressure,injection duration,and nozzle diameter.Through detailed analyses,it was found that the pressure and temperature during the water-melt interaction exhibited a consistent variation trend with our previous water-droplet injection mode LBE experiment.Similarly,the existence of a steam explosion was confirmed,which typically results in a much stronger pressure build-up.For the non-explosion cases,increasing the injection pressure,melt-pool temperature,nozzle diameter,and water subcooling promoted pressure build-up in the melt pool.However,a limited enhancement effect was observed when increasing the injection duration,which may be owing to the continually rising pressure in the interaction vessel or the isolation effect of the generated steam cavity.Regardless of whether a steam explosion occurred,the calculated mechanical and kinetic energy conversion efficiencies of the melt were relatively small(not exceeding 4.1%and 0.7%,respectively).Moreover,the range of the conversion efficiency was similar to that of previous water-droplet experiments,although the upper limit of the jet mode was slightly lower.
基金the National Key Research and Development Program of China(2021YFF0900800)the National Natural Science Foundation of China(61972276,62206116,62032016)+2 种基金the New Liberal Arts Reform and Practice Project of National Ministry of Education(2021170002)the Open Research Fund of the State Key Laboratory for Management and Control of Complex Systems(20210101)Tianjin University Talent Innovation Reward Program for Literature and Science Graduate Student(C1-2022-010)。
文摘Powered by advanced information technology,more and more complex systems are exhibiting characteristics of the cyber-physical-social systems(CPSS).In this context,computational experiments method has emerged as a novel approach for the design,analysis,management,control,and integration of CPSS,which can realize the causal analysis of complex systems by means of“algorithmization”of“counterfactuals”.However,because CPSS involve human and social factors(e.g.,autonomy,initiative,and sociality),it is difficult for traditional design of experiment(DOE)methods to achieve the generative explanation of system emergence.To address this challenge,this paper proposes an integrated approach to the design of computational experiments,incorporating three key modules:1)Descriptive module:Determining the influencing factors and response variables of the system by means of the modeling of an artificial society;2)Interpretative module:Selecting factorial experimental design solution to identify the relationship between influencing factors and macro phenomena;3)Predictive module:Building a meta-model that is equivalent to artificial society to explore its operating laws.Finally,a case study of crowd-sourcing platforms is presented to illustrate the application process and effectiveness of the proposed approach,which can reveal the social impact of algorithmic behavior on“rider race”.
基金financially supported by Central Public-interest Scientific Institution Basal Research Fund,CAFS(Grant Nos.2023TD88,2024HY-ZC005,and 2024XT0801).
文摘Fishing boats are usually anchored side by side in the harbor because of the small structural size and poor resistance to wind and waves.A series of physical model experiments are conducted to investigate the motion characteristics of multiple fishing boats that are moored together.A decay test in calm water is conducted to study the natural period and damping coefficients.Regular wave experiments are performed to analyze the roll motion response of each boat for four modes(different numbers of boats side-by-side).The results indicate that the“natural period”of each boat for the mode of multi-boats especially three or four boats,is slightly smaller than that of a single boat,whereas the damping coefficient is visibly larger than that of a single boat.The maximum roll angle of each boat does not appear at the same time under a 90°incident wave.Small roll motion energy is generated at low frequencies and high frequencies when multiple boats are moored together.The energy decreases with the increasing wave period.The roll motion responses of each boat in four modes exhibit different trends with the increasing wave frequency.The number of boats and boat position have significant effects on roll motion.
基金Project(52227901)supported by the National Natural Science Foundation of ChinaProject(2308085ME153)supported by the Anhui Provincial Natural Science Foundation,China+2 种基金Project(2022AH030088)supported by the University Natural Science Foundation of Anhui Province,ChinaProject(EC2022011)supported by the Foundation of Joint National-Local Engineering Research Centre for Safe and Precise Coal Mining,ChinaProject(GXXT-2022-020)supported by the University Synergy Innovation Program of Anhui Province,China。
文摘In recent years,rockburst have gained significant attention as a crucial topic in rock engineering.Strain andfault-slip rockburst are two common types that occur frequently and cause substantial damage.The objective of thisreview is to conduct a comprehensive study on the experiments and failure mechanisms of strain and fault-slip rockburst.Firstly,the article analyzes the evolving trends in experimental research on rockburst in the past decade,highlightingmechanical properties and failure modes as the primary research focuses in understanding rockburst mechanisms.Subsequently,it provides an overview of the experimental techniques and methods employed for studying both types ofrockburst.Then,with a focus on the mechanical properties and failure modes,the article conducts an extensive analysisof the failure mechanisms associated with strain and fault-slip rockburst.By analyzing experimental data and observingthe failure characteristics of samples,it discusses the variations and common features exhibited by these two types ofrockburst under various test conditions.This analysis is of paramount importance in revealing the causes of rockburstformation and development,as well as in predicting rockburst trends and assessing associated risks.Lastly,thelimitations of current rockburst experiments and future research directions are discussed,followed by a comprehensivesummary of the entire article.
基金supported by the National Natural Science Foundation of China (32322064,32101340)the Jiangsu Provincial Natural Science Foundation for Distinguished Young Scholars (BK20220083)+1 种基金the Carbon Peak and Carbon Neutralization Key Science and technology Program of Suzhou (ST202228)Songhan Wang acknowledges the Young Elite Scientists Sponsorship Program by China Association for Science and Technology (2021QNRC001).
文摘Accurate prediction of future rice yield needs the precise estimations of rice yield response to climate change factors,of which the most important one is the increasing carbon dioxide(CO_(2))concentrations.Estimates of CO_(2) fertilization effect(CFE)on rice,however,still had large uncertainties.Therefore,using the rice planting areas in East China as the study area,we firstly compared the rice yields and CFE predicted by four state-of-the-art crop models,and found that the CFE predicted by these models had significant differences.We then quantified the CFE on rice yield using the field-controlled experiment conducted at Danyang site at Jiangsu province.Using CFE measurements from a field experiment as benchmark,we have developed an experiment–model integration approach aiming to reduce this variation.This study thus highlights the large CFE uncertainties of current crop models and provides us with a method to reduce this uncertainty,which is beneficial for the accurate prediction of future global rice yield in the context of climate change.
