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The development of Fructus corni quality standard considering the effects of processing 被引量:2
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作者 Xingchu Gong Junlin Guo +1 位作者 Jingjing Pan Zhenfeng Wu 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2021年第1期77-84,共8页
The quality standards for Fructus Comi have been established based on the effects of the manufacturing processes.Three critical process parameters(CPPs)of extraction,filtration,and concentration to prepare Fructus Com... The quality standards for Fructus Comi have been established based on the effects of the manufacturing processes.Three critical process parameters(CPPs)of extraction,filtration,and concentration to prepare Fructus Comi concentrate were identified by Plackett-Burman design with a single batch of Fructus Corni,which were heating medium temperature,extraction time,and water addition.Morroniside yield,loganin yield,and dry matter yield were process critical quality attributes(CQAs).CPPs arranged with a Box-Behnken design were applied to treat different batches of Fructus Comi After constructing a model that included CPPs,material propertie s,and process CQAs,loganin content was found to be the critical material attribute(CMA).The design space was calculated with a probability method.According to the limits of process CQAs,the minimum content of loganin in Fructus Corni was calculated with an error propagation method,which was 6.92 mg·g^(-1).When the content of loganin in Fructus Corni reaches up to 6.92 mg·g^(-1),the material is considered high-quality and is most suitable for the process.High-quality material can be used for production of Fructus Comi concentrate.This method can also be used to set material quality standards for other Chinese medicines. 展开更多
关键词 Material quality standard Critical process parameters Control strategy LOGANIN formulated granules
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Effect Comparison of different formulation of Dang-Gui-Bu-Xu-Tang on myelosuppression mouse 被引量:9
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作者 Suchun Yan Yiqiang Xie +2 位作者 Bide Zhu Yingguang Han Wei Guo 《Asian Pacific Journal of Tropical Medicine》 SCIE CAS 2011年第7期556-559,共4页
Objective: To compare effect of different formulation of Dang-Gui-Bu-Xu-Tang(DCBXT) on myelosuppression mouse. Methods: HPLC was used to measure active ingredients of two DCBXT formulations. Hemopoesic function of bon... Objective: To compare effect of different formulation of Dang-Gui-Bu-Xu-Tang(DCBXT) on myelosuppression mouse. Methods: HPLC was used to measure active ingredients of two DCBXT formulations. Hemopoesic function of bone marrow was measured by hemopoietic progenitor cell culture and peipheral blood count. And hemopoietic factors in bone marrow were tested by ELISA. Results: The content level of astragaloside A in granule formulation was higher than that in decoction and the content ratio of active ingredient was close to 5 : 1. Two DGBXD formulations could significantly improve amount of peripheral blood cells, and bone marrow cells of bone marrow suppression mice (P < 0.05). DGBXD granule formulation significantly increased the colony quantity of all progenitor cell lines and amount of G(2)/M and S phase cells (P < 0.05). It also significantly decreased amount of G(0)/G(1) phase cells in the bone marrow and was more effective (P < 0.05). Conclusions: DGBXT decoction and the granule formulation all can improve the hematopoietic function of bone marrow suppression mouse. They can improve quantities of peripheral blood and nucleated bone marrow cells, and yield of the hematopoietic stem/progenitor cells in vitro colony; balance the expression of cytokine (EPO, TPO and GM-CSF) in bone marrow microenvirement. They can also facilitate hematopoietic stem/progenitor cells to enter the cell cycle. And the effect of granule formulation is more satisfactory. 展开更多
关键词 DGBXT granule formulation MYELOSUPPRESSION Hematopoietic regulation HCMV
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