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The bio-active components of the Mongolian medicine Horcha-6 and therapeutic mechanism in the rat migraine model
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作者 Ao Qier Naren Mandula +7 位作者 Qiburi Qiburi Manda Manda Tegexi Baiyin Xilinqiqige Bao Huricha Baigued Chang-Shan Wang Temuqile Temuqile De-Zhi Yang 《Traditional Medicine Research》 2024年第2期8-17,共10页
Background:The active components of Horcha-6 were identified using liquid chromatography with tandem mass spectrometry.Also,we investigated the potential mechanisms that explain why Horcha-6 may be effective in treati... Background:The active components of Horcha-6 were identified using liquid chromatography with tandem mass spectrometry.Also,we investigated the potential mechanisms that explain why Horcha-6 may be effective in treating migraines through the use of network pharmacology and a rat migraine model.Methods:After identifying the active components of Horcha-6,the corresponding genes of the active components’target were obtained from the Universal Protein database,and a“compound-target-disease”network was constructed using Cytoscape 3.9.0 software.For the in vivo experiments,nitroglycerin was injected intraperitoneally into rats to create a migraine model.Pre-treatment with Horcha-6 was administered orally for 14 days,and rats were subjected to migraine-related behavior tests.RNA sequencing was performed to identify the gene expression regulated by Horcha-6 in the trigeminal nerve.Results:A total of 903 chemical components of Horcha-6 have been collected in the liquid chromatography with tandem mass spectrometry.We discovered 55 of the Horcha-6 bio-active components that were evaluated based on their Percent Human Oral Absorption(≥30%)and DL values(≥0.185)on the traditional Chinese medicine systems pharmacology database.The“compound-target-disease”network contained 163 intersection targets with the migraine state.Gene Ontology analysis indicated that these components significantly regulated the immune response,vascular function,oxidative stress,etc.When Kyoto Encyclopedia of Genes and Genomes enrichment analysis was performed,we observed that most of the target genes were significantly enriched in the inflammation and neuro-related signaling pathway,toll-like receptor signaling pathway,neuroactive ligand-receptor interaction,etc.These predictions were further demonstrated via in vivo animal model experiments.The RNA sequencing results showed that 41 genes were down-regulated(P<0.05)and 86 genes were up-regulated(P<0.05)in the Horcha-6 treated group compared with the untreated group.Those genes were mainly involved in neuromodulation,vascular function,and hormone metabolism.Conclusion:The 55 bio-active components in Horcha-6 regulate inflammation,hormone metabolism,and neurotransmitters and have potential as a therapy to treat migraines. 展开更多
关键词 Horcha-6 bio-active components rat migraine model inflammation hormone metabolism NEUROTRANSMITTER
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A new production component method for natural gas development planning
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作者 Fanliao Wang Jiangchen Han +4 位作者 Shucheng Liu Yanqing Liu Kun Su Jing Du Liru Wang 《Energy Geoscience》 EI 2024年第1期283-292,共10页
Based on an analysis of the limitations of conventional production component methods for natural gas development planning,this study proposes a new one that uses life cycle models for the trend fitting and prediction ... Based on an analysis of the limitations of conventional production component methods for natural gas development planning,this study proposes a new one that uses life cycle models for the trend fitting and prediction of production.In this new method,the annual production of old and new wells is predicted by year first and then is summed up to yield the production for the planning period.It shows that the changes in the production of old wells in old blocks can be fitted and predicted using the vapor pressure model(VPM),with precision of 80%e95%,which is 6.6%e13.2%higher than that of other life cycle models.Furthermore,a new production prediction process and method for new wells have been established based on this life cycle model to predict the production of medium-to-shallow gas reservoirs in western Sichuan Basin,with predication error of production rate in 2021 and 2022 being 6%and 3%respectively.The new method can be used to guide the medium-and long-term planning or annual scheme preparation for gas development.It is also applicable to planning for large single gas blocks that require continuous infill drilling and adjustment to improve gas recovery. 展开更多
关键词 Production component method Production prediction Life cycle model Gas development planning Western Sichuan Basin
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A blast furnace fault monitoring algorithm with low false alarm rate:Ensemble of greedy dynamic principal component analysis-Gaussian mixture model 被引量:1
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作者 Xiongzhuo Zhu Dali Gao +1 位作者 Chong Yang Chunjie Yang 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2023年第5期151-161,共11页
The large blast furnace is essential equipment in the process of iron and steel manufacturing. Due to the complex operation process and frequent fluctuations of variables, conventional monitoring methods often bring f... The large blast furnace is essential equipment in the process of iron and steel manufacturing. Due to the complex operation process and frequent fluctuations of variables, conventional monitoring methods often bring false alarms. To address the above problem, an ensemble of greedy dynamic principal component analysis-Gaussian mixture model(EGDPCA-GMM) is proposed in this paper. First, PCA-GMM is introduced to deal with the collinearity and the non-Gaussian distribution of blast furnace data.Second, in order to explain the dynamics of data, the greedy algorithm is used to determine the extended variables and their corresponding time lags, so as to avoid introducing unnecessary noise. Then the bagging ensemble is adopted to cooperate with greedy extension to eliminate the randomness brought by the greedy algorithm and further reduce the false alarm rate(FAR) of monitoring results. Finally, the algorithm is applied to the blast furnace of a large iron and steel group in South China to verify performance.Compared with the basic algorithms, the proposed method achieves lowest FAR, while keeping missed alarm rate(MAR) remain stable. 展开更多
关键词 Chemical processes Principal component analysis Gaussian mixture model Process monitoring ENSEMBLE Process control
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Applications of Computer Aided Modeling Techniques to Complex ICE Components 被引量:1
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作者 左正兴 冯慧华 +1 位作者 廖日东 邹文胜 《Journal of Beijing Institute of Technology》 EI CAS 2000年第4期451-458,共8页
Design of internal combustion engine (ICE) components is one of the earliest and also the most active areas in which computer aided modeling techniques are applied. Computer aided modeling techniques could provide req... Design of internal combustion engine (ICE) components is one of the earliest and also the most active areas in which computer aided modeling techniques are applied. Computer aided modeling techniques could provide requisite information for follow up designing segments such as structural analysis, design of technological process and manufacturing etc, and thereby lead to the reduction of product design period and the quality and reliability improvement of ICE components. So the developing situations of ICE components' 2 D drafting, 3 D modeling of ICE, overall CAD of ICE as well as component design expert system etc. are surveyed, which are the typical applications of computer aided modeling techniques in ICE component design process, and some existent problems and tasks are pointed out so as to make some references for the further research work. 展开更多
关键词 internal combustion engine(ICE) components computer aided modeling CAD 3 D model
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EMPIRICAL BAYES TEST PROBLEMS OF VARIANCE COMPONENTS IN RANDOM EFFECTS MODEL 被引量:3
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作者 韦来生 张伟平 《Acta Mathematica Scientia》 SCIE CSCD 2005年第2期274-282,共9页
Bayes decision rule of variance components for one-way random effects model is derived and empirical Bayes (EB) decision rules are constructed by kernel estimation method. Under suitable conditions, it is shown that t... Bayes decision rule of variance components for one-way random effects model is derived and empirical Bayes (EB) decision rules are constructed by kernel estimation method. Under suitable conditions, it is shown that the proposed EB decision rules are asymptotically optimal with convergence rates near O(n-1/2). Finally, an example concerning the main result is given. 展开更多
关键词 Empirical Bayes test variance components random effects model convergence rates
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U-Net Models for Representing Wind Stress Anomalies over the Tropical Pacific and Their Integrations with an Intermediate Coupled Model for ENSO Studies 被引量:1
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作者 Shuangying Du Rong-Hua Zhang 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2024年第7期1403-1416,共14页
El Niño-Southern Oscillation(ENSO)is the strongest interannual climate mode influencing the coupled ocean-atmosphere system in the tropical Pacific,and numerous dynamical and statistical models have been develope... El Niño-Southern Oscillation(ENSO)is the strongest interannual climate mode influencing the coupled ocean-atmosphere system in the tropical Pacific,and numerous dynamical and statistical models have been developed to simulate and predict it.In some simplified coupled ocean-atmosphere models,the relationship between sea surface temperature(SST)anomalies and wind stress(τ)anomalies can be constructed by statistical methods,such as singular value decomposition(SVD).In recent years,the applications of artificial intelligence(AI)to climate modeling have shown promising prospects,and the integrations of AI-based models with dynamical models are active areas of research.This study constructs U-Net models for representing the relationship between SSTAs andτanomalies in the tropical Pacific;the UNet-derivedτmodel,denoted asτUNet,is then used to replace the original SVD-basedτmodel of an intermediate coupled model(ICM),forming a newly AI-integrated ICM,referred to as ICM-UNet.The simulation results obtained from ICM-UNet demonstrate their ability to represent the spatiotemporal variability of oceanic and atmospheric anomaly fields in the equatorial Pacific.In the ocean-only case study,theτUNet-derived wind stress anomaly fields are used to force the ocean component of the ICM,the results of which also indicate reasonable simulations of typical ENSO events.These results demonstrate the feasibility of integrating an AI-derived model with a physics-based dynamical model for ENSO modeling studies.Furthermore,the successful integration of the dynamical ocean models with the AI-based atmospheric wind model provides a novel approach to ocean-atmosphere interaction modeling studies. 展开更多
关键词 U-Net models wind stress anomalies ICM integration of AI and physical components
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SOFTWARE RELIABILITY MODEL FOR COMPONENT INTERACTION MODE 被引量:2
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作者 Wang Qiang Lu Yang +1 位作者 Xu Zijun Han Jianghong 《Journal of Electronics(China)》 2011年第4期632-642,共11页
With the rapid progress of component technology,the software development methodology of gathering a large number of components for designing complex software systems has matured.But,how to assess the application relia... With the rapid progress of component technology,the software development methodology of gathering a large number of components for designing complex software systems has matured.But,how to assess the application reliability accurately with the information of system architecture and the components reliabilities together has become a knotty problem.In this paper,the defects in formal description of software architecture and the limitations in existed model assumptions are both analyzed.Moreover,a new software reliability model called Component Interaction Mode(CIM) is proposed.With this model,the problem for existed component-based software reliability analysis models that cannot deal with the cases of component interaction with non-failure independent and non-random control transition is resolved.At last,the practice examples are presented to illustrate the effectiveness of this model. 展开更多
关键词 component CONNECTOR Software architecture Reliability model
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Local component based principal component analysis model for multimode process monitoring 被引量:4
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作者 Yuan Li Dongsheng Yang 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2021年第6期116-124,共9页
For plant-wide processes with multiple operating conditions,the multimode feature imposes some challenges to conventional monitoring techniques.Hence,to solve this problem,this paper provides a novel local component b... For plant-wide processes with multiple operating conditions,the multimode feature imposes some challenges to conventional monitoring techniques.Hence,to solve this problem,this paper provides a novel local component based principal component analysis(LCPCA)approach for monitoring the status of a multimode process.In LCPCA,the process prior knowledge of mode division is not required and it purely based on the process data.Firstly,LCPCA divides the processes data into multiple local components using finite Gaussian mixture model mixture(FGMM).Then,calculating the posterior probability is applied to determine each sample belonging to which local component.After that,the local component information(such as mean and standard deviation)is used to standardize each sample of local component.Finally,the standardized samples of each local component are combined to train PCA monitoring model.Based on the PCA monitoring model,two monitoring statistics T^(2) and SPE are used for monitoring multimode processes.Through a numerical example and the Tennessee Eastman(TE)process,the monitoring result demonstrates that LCPCA outperformed conventional PCA and LNS-PCA in the fault detection rate. 展开更多
关键词 Principal component analysis Finite Gaussian mixture model Process monitoring Tennessee Eastman(TE)process
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Leakage Rate Model of Urban Water Supply Networks Using Principal Component Regression Analysis 被引量:1
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作者 Zhiguang Niu Chong Wang +2 位作者 Ying Zhang Xiaoting Wei Xili Gao 《Transactions of Tianjin University》 EI CAS 2018年第2期172-181,共10页
To analyze the factors affecting the leakage rate of water distribution system, we built a macroscopic "leakage rate–leakage factors"(LRLF) model. In this model, we consider the pipe attributes(quality, dia... To analyze the factors affecting the leakage rate of water distribution system, we built a macroscopic "leakage rate–leakage factors"(LRLF) model. In this model, we consider the pipe attributes(quality, diameter,age), maintenance cost, valve replacement cost, and annual average pressure. Based on variable selection and principal component analysis results, we extracted three main principle components—the pipe attribute principal component(PAPC), operation management principal component, and water pressure principal component. Of these, we found PAPC to have the most influence. Using principal component regression, we established an LRLF model with no detectable serial correlations. The adjusted R2 and RMSE values of the model were 0.717 and 2.067, respectively.This model represents a potentially useful tool for controlling leakage rate from the macroscopic viewpoint. 展开更多
关键词 Water DISTRIBUTION system LEAKAGE RATE LEAKAGE influencing FACTOR QUANTITATIVE model Principal component regression
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Evaluation of Component Activities in C-Mn-Fe-Si with Model Self-SReM4 被引量:1
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作者 Zhang Xiaobing Jiang Guochang +1 位作者 Ding Weizhong Xu Kuangdi 《Journal of Iron and Steel Research International》 SCIE EI CAS CSCD 1998年第1期28-33,共6页
A sub-regular solution model SELFSReM4 used to evaluate activities of the components in a homogeneous region of a quaternary system has been developed in Shanghai Enhanced Lab of Ferrometallurgy. This paper introduces... A sub-regular solution model SELFSReM4 used to evaluate activities of the components in a homogeneous region of a quaternary system has been developed in Shanghai Enhanced Lab of Ferrometallurgy. This paper introduces the application of SELFSReM4 in evaluating activities of the components in C-Mn-Fe-Si system without SiC precipitation. 展开更多
关键词 sub-regular solution model component activity C-Mn-Si-Fe alloy
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Evaluation of Component Activity in Molten MnO-SiO_(2)-Al_(2)O_(3)-CaO System with Model SELF-SReM4 被引量:1
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作者 ZHANG Xiao-bing JIANG Guo-chang XU Kuang-di 《Journal of Iron and Steel Research International》 SCIE EI CAS CSCD 2000年第1期6-8,共3页
A sub-regular solution model SELF-SReM4 used to evaluate activity of the components in a homogeneous region of a quaternary system has been developed in Shanghai Enhanced Laboratory of Ferrometallurgy.The application ... A sub-regular solution model SELF-SReM4 used to evaluate activity of the components in a homogeneous region of a quaternary system has been developed in Shanghai Enhanced Laboratory of Ferrometallurgy.The application of SELF-SReM4 in C-Mn-Fe-Si system without the SiC formation has been introduced in previous paper.It’s application for molten slag of MnO-SiO2-Al2O3-CaO was introduced in this paper.They provide a basis for the prediction of the metal-slag equilibrium conditions. 展开更多
关键词 sub-regular solution model component activity m olten slag MnO-SiO2-Al2O3-CaO
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Nonlinear total least-squares variance component estimation for GM(1,1)model 被引量:2
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作者 Leyang Wang Jianqiang Sun Qiwen Wu 《Geodesy and Geodynamics》 CSCD 2021年第3期211-217,共7页
The solution of the grey model(GM(1,1)model)generally involves equal-precision observations,and the(co)variance matrix is established from the prior information.However,the data are generally available with unequal-pr... The solution of the grey model(GM(1,1)model)generally involves equal-precision observations,and the(co)variance matrix is established from the prior information.However,the data are generally available with unequal-precision measurements in reality.To deal with the errors of all observations for GM(1,1)model with errors-in-variables(EIV)structure,we exploit the total least-squares(TLS)algorithm to estimate the parameters of GM(1,1)model in this paper.Ignoring that the effect of the improper prior stochastic model and the homologous observations may degrade the accuracy of parameter estimation,we further present a nonlinear total least-squares variance component estimation approach for GM(1,1)model,which resorts to the minimum norm quadratic unbiased estimation(MINQUE).The practical and simulative experiments indicate that the presented approach has significant merits in improving the predictive accuracy in comparison with control methods. 展开更多
关键词 GM(1 1)model Minimum norm quadratic unbiased estimation(MINQUE) Total least-squares(TLS) Unequal-precision measurement Variance component estimation(VCE)
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Real-time lane departure warning system based on principal component analysis of grayscale distribution and risk evaluation model 被引量:4
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作者 张伟伟 宋晓琳 张桂香 《Journal of Central South University》 SCIE EI CAS 2014年第4期1633-1642,共10页
A technology for unintended lane departure warning was proposed. As crucial information, lane boundaries were detected based on principal component analysis of grayscale distribution in search bars of given number and... A technology for unintended lane departure warning was proposed. As crucial information, lane boundaries were detected based on principal component analysis of grayscale distribution in search bars of given number and then each search bar was tracked using Kalman filter between frames. The lane detection performance was evaluated and demonstrated in ways of receiver operating characteristic, dice similarity coefficient and real-time performance. For lane departure detection, a lane departure risk evaluation model based on lasting time and frequency was effectively executed on the ARM-based platform. Experimental results indicate that the algorithm generates satisfactory lane detection results under different traffic and lighting conditions, and the proposed warning mechanism sends effective warning signals, avoiding most false warning. 展开更多
关键词 lane departure warning system lane detection lane tracking principal component analysis risk evaluation model ARM-based real-time system
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Application of synthetic principal component analysis model to mine area farmland heavy metal pollution assessment 被引量:1
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作者 王从陆 吴超 王卫军 《Journal of Coal Science & Engineering(China)》 2008年第1期109-113,共5页
Referring to GB5618-1995 about heavy metal pollution,and using statistical analysis SPSS,the major pollutants of mine area farmland heavy metal pollution were identified by variable clustering analysis.Assessment and ... Referring to GB5618-1995 about heavy metal pollution,and using statistical analysis SPSS,the major pollutants of mine area farmland heavy metal pollution were identified by variable clustering analysis.Assessment and classification were done to the mine area farmland heavy metal pollution situation by synthetic principal components analysis (PCA).The results show that variable clustering analysis is efficient to identify the principal components of mine area farmland heavy metal pollution.Sort and clustering were done to the synthetic principal components scores of soil sample,which is given by synthetic principal components analysis.Data structure of soil heavy metal contaminations relationships and pollution level of different soil samples are discovered.The results of mine area farmland heavy metal pollution quality assessed and classified with synthetic component scores reflect the influence of both the major and compound heavy metal pol- lutants.Identification and assessment results of mine area farmland heavy metal pollution can provide reference and guide to propose control measures of mine area farmland heavy metal pollution and focus on the key treatment region. 展开更多
关键词 synthetic principal components analysis model heavy metal pollution mineregional soils
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Fault diagnosis method for an Aeroengine Based on Independent Component Analysis and the Discrete Hidden Markov Model 被引量:1
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作者 MA Jian-cang ZENG Yuan 《International Journal of Plant Engineering and Management》 2009年第4期193-201,共9页
The vibration signals of an aeroengine are a very important information source for fault diagnosis and condition monitoring. Considering the nonstationarity and low repeatability of the vibration signals, it is necess... The vibration signals of an aeroengine are a very important information source for fault diagnosis and condition monitoring. Considering the nonstationarity and low repeatability of the vibration signals, it is necessary to find a corresponding method for feature extraction and fault recognition. In this paper, based on Independent Component Analysis (ICA) and the Discrete Hidden Markov Model (DHMM), a new fault diagnosis approach named ICA-DHMM is proposed. In this method, ICA separates the source signals from the mixed vibration signals and then extracts features from them, DHMM works as a classifier to recognize the conditions of the aeroengine. Compared with the DHMM, which use the amplitude spectrum of mixed signals as feature parameters, experimental results show this method has higher diagnosis accuracy. 展开更多
关键词 independent component analysis (ICA) feature extraction discrete hidden Markov model DHMM) AEROENGINE fault diagnosis
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Estimation on principal component of multi-collinearity Gauss-Markov model based on minimum description length
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作者 SHI Yu-feng~(1, 2) (1. Shandong University of Technology, Zibo 255049, China 2. Key Laboratory of Geospace Environment and Geodesy, Ministry of Education, Wuhan University, Wuhan 430079, China) 《中国有色金属学会会刊:英文版》 CSCD 2005年第S1期153-155,共3页
Gauss-Markov model is frequently used in data analysis; the analysis and estimation of its parameters is always a hot issue. Based on the information theory and from the viewpoint of optimal information on description... Gauss-Markov model is frequently used in data analysis; the analysis and estimation of its parameters is always a hot issue. Based on the information theory and from the viewpoint of optimal information on description—minimum description length, this paper discusses a case: where there is multi-collinearity in the coefficient matrix, principal component estimation is used to estimate and select the original parameters, so as to reduce its multi-collinearity and improve its credibility. From the viewpoint of minimum description length, this paper discusses the approach of selecting principal components and uses this approach to solve a practical problem. 展开更多
关键词 minimum DESCRIPTION LENGTH Gauss-Markov model multi-collinearity principal component ESTIMATION
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Novel Sum-of-Sinusoids Simulation Channel Modeling for 6G Multiple-Input Multiple-Output Vehicle-to-Everything Communications
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作者 Hao Jiang Hongming Zhang Ting Liu 《China Communications》 SCIE CSCD 2024年第1期242-259,共18页
In this paper,a statistical cluster-based simulation channel model with a finite number of sinusoids is proposed for depicting the multiple-input multiple-output(MIMO)communications in vehicleto-everything(V2X)environ... In this paper,a statistical cluster-based simulation channel model with a finite number of sinusoids is proposed for depicting the multiple-input multiple-output(MIMO)communications in vehicleto-everything(V2X)environments.In the proposed sum-of-sinusoids(SoS)channel model,the waves that emerge from the transmitter undergo line-of-sight(LoS)and non-line-of-sight(NLoS)propagation to the receiver,which makes the model suitable for describing numerous V2X wireless communication scenarios for sixth-generation(6G).We derive expressions for the real and imaginary parts of the complex channel impulse response(CIR),which characterize the physical propagation characteristics of V2X wireless channels.The statistical properties of the real and imaginary parts of the complex CIRs,i.e.,autocorrelation functions(ACFs),Doppler power spectral densities(PSDs),cross-correlation functions(CCFs),and variances of ACFs and CCFs,are derived and discussed.Simulation results are generated and match those predicted by the underlying theory,demonstrating the accuracy of our derivation and analysis.The proposed framework and underlying theory arise as an efficient tool to investigate the statistical properties of 6G MIMO V2X communication systems. 展开更多
关键词 complex CIRs LoS and NLoS propagation components MIMO V2X communication environments SoS simulation channel model statistical properties
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Education Knowledge System Combination Model Based on the Components
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作者 CHEN Lei LI Dehua +1 位作者 LI Xiaojian WU Chunxiang 《Wuhan University Journal of Natural Sciences》 CAS 2007年第6期1013-1018,共6页
Resources are the base and core of education information, but current web education resources have no structure and it is still difficult to reuse them and make them can be self assembled and developed continually. Ac... Resources are the base and core of education information, but current web education resources have no structure and it is still difficult to reuse them and make them can be self assembled and developed continually. According to the knowledge structure of course and text, the relation among knowledge points, knowledge units from three levels of media material, we can build education resource components, and build TKCM (Teaching Knowledge Combination Model) based on resource components. Builders can build and assemble knowledge system structure and make knowledge units can be self assembled, thus we can develop and consummate them continually. Users can make knowledge units can be self assembled and renewed, and build education knowledge system to satisfy users' demand under the form of education knowledge system. 展开更多
关键词 knowledge unit components education knowledge system knowledge combination model
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A fault injection model-oriented testing strategy for component security
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作者 陈锦富 卢炎生 +1 位作者 张卫 谢晓东 《Journal of Central South University》 SCIE EI CAS 2009年第2期258-264,共7页
A fault injection model-oriented testing strategy was proposed for detecting component vulnerabilities.A fault injection model was defined,and the faults were injected into the tested component based on the fault inje... A fault injection model-oriented testing strategy was proposed for detecting component vulnerabilities.A fault injection model was defined,and the faults were injected into the tested component based on the fault injection model to trigger security exceptions.The testing process could be recorded by the monitoring mechanism of the strategy,and the monitoring information was written into the security log.The component vulnerabilities could be detected by the detecting algorithm through analyzing the security log.Lastly,some experiments were done in an integration testing platform to verify the applicability of the strategy.The experimental results show that the strategy is effective and operable.The detecting rate is more than 90%for vulnerability components. 展开更多
关键词 component testing component security fault injection model testing strategy detecting algorithm
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Stochastic Four-State Mechanochemical Model of F_1-ATPase
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作者 吴魏霞 展永 +2 位作者 赵同军 韩英荣 陈娅斐 《Communications in Theoretical Physics》 SCIE CAS CSCD 2010年第10期630-634,共5页
F_1-ATPase, a part of ATP synthase, can synthesize and hydrolyze ATP moleculars in which the centralγ-subunit rotates inside the α_3β_3 cylinder.A stochastic four-state mechanochemical coupling model of F_1-ATPase ... F_1-ATPase, a part of ATP synthase, can synthesize and hydrolyze ATP moleculars in which the centralγ-subunit rotates inside the α_3β_3 cylinder.A stochastic four-state mechanochemical coupling model of F_1-ATPase isstudied with the aid of the master equation.In this model, the ATP hydrolysis and synthesis are dependent on ATP,ADP, and Pi concentrations.The effects of ATP concentration, ADP concentration, and the external torque on theoccupation probability of binding-state, the rotation rate and the diffusion coefficient of F_1-ATPase are investigated.Moreover, the results from this model are compared with experiments.The mechanochemical mechanism F_1-ATPase isqualitatively explained by the model. 展开更多
关键词 F1-ATPase four-state mechanochemical model hydrolysis reaction the master equation
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