A systematic geological and geochemical study was conducted for the granitoids of different periods in the western Kunlun orogenic belt. The study indicates that the granitoids belong to tholeiitic, calc-alkaline, hig...A systematic geological and geochemical study was conducted for the granitoids of different periods in the western Kunlun orogenic belt. The study indicates that the granitoids belong to tholeiitic, calc-alkaline, high-K calc-alkaline, alkaline and shoshonitic series, and that there are 5 genetic types, i.e., I-, S-, M-, A- and SH-type, of which SH-type is first put forward in this paper, which corresponds to shoshonitic granitoids.展开更多
As a typical Palaeozoic island arc system, the eastern Tianshan area, Xinjiang, is different from eastern China but similar to the Meso-Cenozoic island arc metallogenic provinces along the coast of the Pacific Ocean i...As a typical Palaeozoic island arc system, the eastern Tianshan area, Xinjiang, is different from eastern China but similar to the Meso-Cenozoic island arc metallogenic provinces along the coast of the Pacific Ocean in metallogenic environment, geology and geochemistry. Three types of gold deposits, ductile shear zone-hosted gold deposits (Kanggur ), magmatic hydrothermal gold deposits (Jinwozi) and volcanic- or subvolcanic-hosted gold deposits (Xitan and Mazhuangshan), have been identified in this area. Regionally, gold deposits are structurally controlled by the Kanggur Tag ductile shear zone, Shaquanzi fault, Hongliuhe fault and Yamansu fault. Generally, gold mineralization occurs in the transition zones from volcanic rocks to sedimentary rocks. The horizon bearing well-developed jasper is an important indicator for gold mineralization. Each of the three types of gold deposits has its distinctive metallogenic background and geological-geochemical characteristics.展开更多
Objective:To characterize the semen of three genetic types of boars(local,improved and Large White)reared in Benin.Methods:Semen of local,improved and Large White boars reared in Benin were collected using the gloved ...Objective:To characterize the semen of three genetic types of boars(local,improved and Large White)reared in Benin.Methods:Semen of local,improved and Large White boars reared in Benin were collected using the gloved hand method and analyzed to determine volume,pH,concentration,mobility,motility,and morphology.The effect of the genetic type of boar on semen characteristics was aslo studied.Results:Duration of ejaculation and semen volume of Large White boar were significantly higher than those of local and improved boars(P<0.05).The semen of improved boars had a higher motility score than that of Large White and local boars(P<0.001).The semen of local boars was more concentrated in the spermatozoa than that of improved and Large White boars(P<0.05).The proportion of spermatozoa of improved boars with normal morphology(93.6%)was significantly higher than that of local(82.2%)and Large White boars(81.6%)(P<0.001).The proportion of spermatozoa with folded tails in the semen of Large White boars(9.2%)was significantly higher than that observed in improved(1.8%)and local(5.0%)boars(P<0.001).The proportion of spermatozoa with proximal cytoplasmic droplets in semen of improved boars(2.7%)was significantly lower than that in Large White(6.8%)and local(9.7%)boars(P<0.001).The local(1.5%)and Large White boars(1.1%)showed more spermatozoa with distal cytoplasmic droplets in their semen compared to the improved boars(0.4%).Conclusions:The semen characteristics of pigs reared in Benin vary from one genetic type to another.Each genetic type has a strong point.The Large White boar produces larger semen,the local boar produces more concentrated semen and the improved boar produces spermatozoa that are morphologically better.The semen of these three genetic types can be used in artificial insemination but the improved boar's semen is more recommended.展开更多
The Jiyang Depression is an important oil and gas production zone in the Bohai Bay Basin.Through a systematic investigation of the gas components and stable carbon isotopes,the genetic types of natural gas found in th...The Jiyang Depression is an important oil and gas production zone in the Bohai Bay Basin.Through a systematic investigation of the gas components and stable carbon isotopes,the genetic types of natural gas found in the Jiyang Depression were determined,that is,biogas,oilassociated gas,coal-derived gas,high-mature oil-related gas,and mantle-derived carbon dioxide(CO_(2)).From the results,natural gas in the Jiyang Depression can be divided into four groups.Group I,which is distributed in the northwest area,is the only typical oil-associated gas.Group II,distributed in the northeast area,is dominated by oil-associated gas,and involves biogas,coal-derived gas,and high-mature oil-related gas.Group Ⅲ,distributed in the southeast area,has all genetic types of gas that are dominated by oil-associated gas and have mantle-derived CO_(2).Group IV,distributed in the southwest area,is dominated by biogas and involves coal-derived gas and oil-associated gas.The differences in each group illustrate the lateral distribution of the natural gas types is characterized by the eastern and southern areas being more complex than the western and northern areas,the vertical distribution of gas reservoirs has no obvious evolutionary law.The main controlling factor analysis of the spatiotemporal changes of the gas reservoirs revealed that the synergy of geochemical characteristics,thermal evolution of the Shahejie Formation and Carboniferous-Permian source rocks,and sealing properties of various faults are jointly responsible for determining the gas reservoir spatiotemporal changes.展开更多
Type 1 diabetes(T1D)is an autoimmune disease that usually strikes early in life,but can affect individuals at almost any age.It is caused by autoreactive T cells that destroy insulin-producing beta cells in the pancre...Type 1 diabetes(T1D)is an autoimmune disease that usually strikes early in life,but can affect individuals at almost any age.It is caused by autoreactive T cells that destroy insulin-producing beta cells in the pancreas.Epidemiological studies estimate a prevalence of 1 in 300 children in the United States with an increasing incidence of 2%-5%annually worldwide.The daily responsibility,clinical management,and vigilance required to maintain blood sugar levels within normal range and avoid acute complications(hypoglycemic episodes and diabetic ketoacidosis)and long term micro-and macro-vascular complications significantly affects quality of life and public health care costs.Given the expansive impact of T1D,research work has accelerated and T1D has been intensively investigated with the focus to better understand,manage and cure this condition.Many advances have been made in the past decades in this regard,but key questions remain as to why certain people develop T1D,but not others,with the glaring example of discordant disease incidence among monozygotic twins.In this review,we discuss the field’s current understanding of its pathophysiology and the role of genetics and environment on the development of T1D.We examine the potential implications of these findings with an emphasis on T1D inheritance patterns,twin studies,and disease prevention.Through a better understanding of this process,interventions can be developed to prevent or halt it at early stages.展开更多
The highest-level interference essence against virus and turnour genetic engineering medicine is a new type created in the 1980s. Compared with chemical medicines, the interference essence has a special effect in the ...The highest-level interference essence against virus and turnour genetic engineering medicine is a new type created in the 1980s. Compared with chemical medicines, the interference essence has a special effect in the treatment of viruses and tumours. The human a, type genetic engineering interference essense is prepared by the Institute of Viruses of the Chinese Academy of Preventive Medical Sciences, the Shanghai Vaccine展开更多
In recent years,a series of highly saturated leakage-type gas hydrates have been discovered in the western Qiongdongnan Basin(QDNB),South China Sea.Based on the molecular compositional and isotopic characteristics of ...In recent years,a series of highly saturated leakage-type gas hydrates have been discovered in the western Qiongdongnan Basin(QDNB),South China Sea.Based on the molecular compositional and isotopic characteristics of the gas samples relevant to the gas hydrates collected from the two leakage-type gas hydrate accumulations in the GMGS5 and GMGS6 drilling zones,a detailed geochemical gas-to-gas correlation was conducted in this study,in order to further understand the geochemical characteristics and possible hydrocarbon sources of these gas hydrates.The natural gas relevant to the gas hydrates in the GMGS5 block is characterized by wet gas(67.96%<%C_(1)<98.58%,C_(1)/C_(1+)<0.9)and significant molecular and carbon isotope fractionation within the depth profile,whereas the gas samples from the GMGS6 block exhibit the characteristics of dry gas(99.25%<%C_(1)<99.81%,C_(1)/C_(1+)>0.9)and lack molecular and carbon isotope fractionation.Approximately 40%‒60%of the methane within the gas hydrate is of microbial origin,while the C^(2+)gas components are typical coal-type gas that are derived from thermogenic source rocks or deeply-buried natural gas fields.In addition,typical in situ primary microbial methane(−80.6‰<δ^(13)C-C_(1)<−67.7‰)was discovered in well W b,which was applied to estimate the contribution of the microbial gas to the gas hydrates.The gas-to-gas correlation results show that the hydrate gases within the two leakage-type gas hydrate accumulations in the GMGS5 and GMGS6 blocks are geochemically different,suggesting that they may have been derived from different source kitchens.Our results further indicate that the deeply-buried thermogenic gas significantly contributed to the shallowly-buried gas hydrates in the western QDNB and multiple effective thermogenic source kitchens provided the hydrocarbon gas in the gas hydrate accumulations.展开更多
The northern Xinjiang region is one of the most significant iron metallogenic provinces in China.Iron deposits are found mainly within three regions:the Altay,western Tianshan,and eastern Tianshan orogenic belts.Previ...The northern Xinjiang region is one of the most significant iron metallogenic provinces in China.Iron deposits are found mainly within three regions:the Altay,western Tianshan,and eastern Tianshan orogenic belts.Previous studies have elaborated on the genesis of Fe deposits in the Altay orogenic belt and western Tianshan.However,the geological characteristics and mineralization history of iron deposits in the eastern Tianshan are still poorly understood.In this paper I describe the geological characteristics of iron deposits in the eastern Tianshan,and discuss their genetic types as well as metallogenic-tectonic settings,Iron deposits are preferentially distributed in central and southern parts of the eastern Tianshan.The known iron deposits in the eastern Tianshan show characteristics of magmatic Fe-Ti-V(e.g.,Weiya and Niumaoquan),sedimentary-metamorphic type(e.g.,Tianhu),and iron skarn(e.g.,Hongyuntan).In addition to the abovementioned iron deposits,many iron deposits in the eastern Tianshan are hosted in submarine volcanic rocks with well-developed skarn mineral assemblages.Their geological characteristics and magnetite compositions suggest that they may belong to distal skarns.SIMS zircon U-Pb analyses suggest that the Fe-Ti oxide ores from Niumaoquan and Weiya deposits were formed at 307.7±1.3 Ma and 242.7±1.9 Ma,respectively.Combined with available isotopic age data,the timing of Fe mineralization in the eastern Tianshan can be divided into four broad intervals:Early Ordovician-Early Silurian(476-438 Ma),Carboniferous(335-303 Ma),Early Permian(295-282 Ma),and Triassic(ca.243 Ma).Each of these episodes corresponds to a period of subduction,post-collision,and intraplate tectonics during the Paleozoic and Mesozoic time.展开更多
Based on the cores from 47 wells and logging data of 130 wells,the main types of sand bodies in the shallow water delta of the Chang 8_(2) sub-member in the Triassic Yanchang Formation,Longdong Area,Ordos Basin were c...Based on the cores from 47 wells and logging data of 130 wells,the main types of sand bodies in the shallow water delta of the Chang 8_(2) sub-member in the Triassic Yanchang Formation,Longdong Area,Ordos Basin were comprehensively analyzed,the distribution characteristics of sand bodies more than 20 m thick were identified,and the genetic types of the thick sand bodies were sorted out.In this region,thick-bed sand bodies can be divided into two types according to the shape and position:type 1 is the sand body in wide strip and is distributed between the average high water mark and the average low water mark;type 2 is distributed on both sides of the average low water mark and is in irregular lump shape.Based on the principle of the volume distribution of sediments and the change rule of accommodation space,the genetic models of two types of thick-bed sand bodies in the Chang 8_(2) sub-member are superimposed distributary channel sand bodies in high accommodation space and superimposed composite sand bodies in low accommodation space.展开更多
The Mediator co-activator complex is a highly conserved,multisubunit protein complex required for gene transcription by RNA polymerase Ⅱ(RNAPⅡ)in all eukaryotes(Allen and Taatjes,2015).This complex,which consists of...The Mediator co-activator complex is a highly conserved,multisubunit protein complex required for gene transcription by RNA polymerase Ⅱ(RNAPⅡ)in all eukaryotes(Allen and Taatjes,2015).This complex,which consists of at least 30 polypeptides,can be divided into four structurally distinct sub-modules including the head,middle,tail,and cyclin-dependent kinase 8(CDK8)展开更多
基金supported by the Key Project(No.9502010)of the former Chinese Ministry of Geology and Mineral Resources.
文摘A systematic geological and geochemical study was conducted for the granitoids of different periods in the western Kunlun orogenic belt. The study indicates that the granitoids belong to tholeiitic, calc-alkaline, high-K calc-alkaline, alkaline and shoshonitic series, and that there are 5 genetic types, i.e., I-, S-, M-, A- and SH-type, of which SH-type is first put forward in this paper, which corresponds to shoshonitic granitoids.
文摘As a typical Palaeozoic island arc system, the eastern Tianshan area, Xinjiang, is different from eastern China but similar to the Meso-Cenozoic island arc metallogenic provinces along the coast of the Pacific Ocean in metallogenic environment, geology and geochemistry. Three types of gold deposits, ductile shear zone-hosted gold deposits (Kanggur ), magmatic hydrothermal gold deposits (Jinwozi) and volcanic- or subvolcanic-hosted gold deposits (Xitan and Mazhuangshan), have been identified in this area. Regionally, gold deposits are structurally controlled by the Kanggur Tag ductile shear zone, Shaquanzi fault, Hongliuhe fault and Yamansu fault. Generally, gold mineralization occurs in the transition zones from volcanic rocks to sedimentary rocks. The horizon bearing well-developed jasper is an important indicator for gold mineralization. Each of the three types of gold deposits has its distinctive metallogenic background and geological-geochemical characteristics.
基金supported by the“Académie de Recherche et d’Enseignement Supérieur(ARES)de la Commission de la Coopération au Développement(CUD)”of Belgium for its support to the realization of this work through Research and Development Project(PRD)titled“Professionalisation of swine value chain actors in the Ouémé and Plateau regions,Benin.”
文摘Objective:To characterize the semen of three genetic types of boars(local,improved and Large White)reared in Benin.Methods:Semen of local,improved and Large White boars reared in Benin were collected using the gloved hand method and analyzed to determine volume,pH,concentration,mobility,motility,and morphology.The effect of the genetic type of boar on semen characteristics was aslo studied.Results:Duration of ejaculation and semen volume of Large White boar were significantly higher than those of local and improved boars(P<0.05).The semen of improved boars had a higher motility score than that of Large White and local boars(P<0.001).The semen of local boars was more concentrated in the spermatozoa than that of improved and Large White boars(P<0.05).The proportion of spermatozoa of improved boars with normal morphology(93.6%)was significantly higher than that of local(82.2%)and Large White boars(81.6%)(P<0.001).The proportion of spermatozoa with folded tails in the semen of Large White boars(9.2%)was significantly higher than that observed in improved(1.8%)and local(5.0%)boars(P<0.001).The proportion of spermatozoa with proximal cytoplasmic droplets in semen of improved boars(2.7%)was significantly lower than that in Large White(6.8%)and local(9.7%)boars(P<0.001).The local(1.5%)and Large White boars(1.1%)showed more spermatozoa with distal cytoplasmic droplets in their semen compared to the improved boars(0.4%).Conclusions:The semen characteristics of pigs reared in Benin vary from one genetic type to another.Each genetic type has a strong point.The Large White boar produces larger semen,the local boar produces more concentrated semen and the improved boar produces spermatozoa that are morphologically better.The semen of these three genetic types can be used in artificial insemination but the improved boar's semen is more recommended.
基金supported by the National Natural Science Foundation of China(Grant Nos.42072172 and 41772120)the Shandong Province Natural Science Fund for Distinguished Young Scholars(No.JQ201311)the Graduate Scientific and Technological Innovation Project Financially Supported by Shandong University of Science and Technology(No.SDKDYC190313).
文摘The Jiyang Depression is an important oil and gas production zone in the Bohai Bay Basin.Through a systematic investigation of the gas components and stable carbon isotopes,the genetic types of natural gas found in the Jiyang Depression were determined,that is,biogas,oilassociated gas,coal-derived gas,high-mature oil-related gas,and mantle-derived carbon dioxide(CO_(2)).From the results,natural gas in the Jiyang Depression can be divided into four groups.Group I,which is distributed in the northwest area,is the only typical oil-associated gas.Group II,distributed in the northeast area,is dominated by oil-associated gas,and involves biogas,coal-derived gas,and high-mature oil-related gas.Group Ⅲ,distributed in the southeast area,has all genetic types of gas that are dominated by oil-associated gas and have mantle-derived CO_(2).Group IV,distributed in the southwest area,is dominated by biogas and involves coal-derived gas and oil-associated gas.The differences in each group illustrate the lateral distribution of the natural gas types is characterized by the eastern and southern areas being more complex than the western and northern areas,the vertical distribution of gas reservoirs has no obvious evolutionary law.The main controlling factor analysis of the spatiotemporal changes of the gas reservoirs revealed that the synergy of geochemical characteristics,thermal evolution of the Shahejie Formation and Carboniferous-Permian source rocks,and sealing properties of various faults are jointly responsible for determining the gas reservoir spatiotemporal changes.
文摘Type 1 diabetes(T1D)is an autoimmune disease that usually strikes early in life,but can affect individuals at almost any age.It is caused by autoreactive T cells that destroy insulin-producing beta cells in the pancreas.Epidemiological studies estimate a prevalence of 1 in 300 children in the United States with an increasing incidence of 2%-5%annually worldwide.The daily responsibility,clinical management,and vigilance required to maintain blood sugar levels within normal range and avoid acute complications(hypoglycemic episodes and diabetic ketoacidosis)and long term micro-and macro-vascular complications significantly affects quality of life and public health care costs.Given the expansive impact of T1D,research work has accelerated and T1D has been intensively investigated with the focus to better understand,manage and cure this condition.Many advances have been made in the past decades in this regard,but key questions remain as to why certain people develop T1D,but not others,with the glaring example of discordant disease incidence among monozygotic twins.In this review,we discuss the field’s current understanding of its pathophysiology and the role of genetics and environment on the development of T1D.We examine the potential implications of these findings with an emphasis on T1D inheritance patterns,twin studies,and disease prevention.Through a better understanding of this process,interventions can be developed to prevent or halt it at early stages.
文摘The highest-level interference essence against virus and turnour genetic engineering medicine is a new type created in the 1980s. Compared with chemical medicines, the interference essence has a special effect in the treatment of viruses and tumours. The human a, type genetic engineering interference essense is prepared by the Institute of Viruses of the Chinese Academy of Preventive Medical Sciences, the Shanghai Vaccine
基金funded by the Key Special Project for Introduced Talents Team of the Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)(Grant No.GML2019ZD0102)the Chinese Geological Survey Project(Grant No.DD20190230 and DD20220224)。
文摘In recent years,a series of highly saturated leakage-type gas hydrates have been discovered in the western Qiongdongnan Basin(QDNB),South China Sea.Based on the molecular compositional and isotopic characteristics of the gas samples relevant to the gas hydrates collected from the two leakage-type gas hydrate accumulations in the GMGS5 and GMGS6 drilling zones,a detailed geochemical gas-to-gas correlation was conducted in this study,in order to further understand the geochemical characteristics and possible hydrocarbon sources of these gas hydrates.The natural gas relevant to the gas hydrates in the GMGS5 block is characterized by wet gas(67.96%<%C_(1)<98.58%,C_(1)/C_(1+)<0.9)and significant molecular and carbon isotope fractionation within the depth profile,whereas the gas samples from the GMGS6 block exhibit the characteristics of dry gas(99.25%<%C_(1)<99.81%,C_(1)/C_(1+)>0.9)and lack molecular and carbon isotope fractionation.Approximately 40%‒60%of the methane within the gas hydrate is of microbial origin,while the C^(2+)gas components are typical coal-type gas that are derived from thermogenic source rocks or deeply-buried natural gas fields.In addition,typical in situ primary microbial methane(−80.6‰<δ^(13)C-C_(1)<−67.7‰)was discovered in well W b,which was applied to estimate the contribution of the microbial gas to the gas hydrates.The gas-to-gas correlation results show that the hydrate gases within the two leakage-type gas hydrate accumulations in the GMGS5 and GMGS6 blocks are geochemically different,suggesting that they may have been derived from different source kitchens.Our results further indicate that the deeply-buried thermogenic gas significantly contributed to the shallowly-buried gas hydrates in the western QDNB and multiple effective thermogenic source kitchens provided the hydrocarbon gas in the gas hydrate accumulations.
基金This research was jointly supported by the National Key R&D Program of China(Nos.2018YFC0603801 and 2018YFC0604004)National Natural Science Foundation of China(Nos.41903042 and 41530206)+1 种基金China Postdoctoral Science Foundation(Nos.2016LH0003 and 2017M610984)open fund of the Key Lab of Mineralogy and Metallogeny,Guangzhou Institute of Geochemistry,Chinese Academy of Sciences(No.KLMM20170202).
文摘The northern Xinjiang region is one of the most significant iron metallogenic provinces in China.Iron deposits are found mainly within three regions:the Altay,western Tianshan,and eastern Tianshan orogenic belts.Previous studies have elaborated on the genesis of Fe deposits in the Altay orogenic belt and western Tianshan.However,the geological characteristics and mineralization history of iron deposits in the eastern Tianshan are still poorly understood.In this paper I describe the geological characteristics of iron deposits in the eastern Tianshan,and discuss their genetic types as well as metallogenic-tectonic settings,Iron deposits are preferentially distributed in central and southern parts of the eastern Tianshan.The known iron deposits in the eastern Tianshan show characteristics of magmatic Fe-Ti-V(e.g.,Weiya and Niumaoquan),sedimentary-metamorphic type(e.g.,Tianhu),and iron skarn(e.g.,Hongyuntan).In addition to the abovementioned iron deposits,many iron deposits in the eastern Tianshan are hosted in submarine volcanic rocks with well-developed skarn mineral assemblages.Their geological characteristics and magnetite compositions suggest that they may belong to distal skarns.SIMS zircon U-Pb analyses suggest that the Fe-Ti oxide ores from Niumaoquan and Weiya deposits were formed at 307.7±1.3 Ma and 242.7±1.9 Ma,respectively.Combined with available isotopic age data,the timing of Fe mineralization in the eastern Tianshan can be divided into four broad intervals:Early Ordovician-Early Silurian(476-438 Ma),Carboniferous(335-303 Ma),Early Permian(295-282 Ma),and Triassic(ca.243 Ma).Each of these episodes corresponds to a period of subduction,post-collision,and intraplate tectonics during the Paleozoic and Mesozoic time.
基金Supported by the National Basic Research Program of China (973 Program)(2014CB239000)China Petroleum Scientific Research and Technology Development Project (YJXK2019-16)。
文摘Based on the cores from 47 wells and logging data of 130 wells,the main types of sand bodies in the shallow water delta of the Chang 8_(2) sub-member in the Triassic Yanchang Formation,Longdong Area,Ordos Basin were comprehensively analyzed,the distribution characteristics of sand bodies more than 20 m thick were identified,and the genetic types of the thick sand bodies were sorted out.In this region,thick-bed sand bodies can be divided into two types according to the shape and position:type 1 is the sand body in wide strip and is distributed between the average high water mark and the average low water mark;type 2 is distributed on both sides of the average low water mark and is in irregular lump shape.Based on the principle of the volume distribution of sediments and the change rule of accommodation space,the genetic models of two types of thick-bed sand bodies in the Chang 8_(2) sub-member are superimposed distributary channel sand bodies in high accommodation space and superimposed composite sand bodies in low accommodation space.
基金partially supported by the National Institutes of Health(R21CA185833 and R01GM113242 to H.S.)the National Natural Science Foundation of China(Nos.81660041 and 81260021 to L.D.)the Education Department of Jiangxi Province(GJJ150219to X.T.)
文摘The Mediator co-activator complex is a highly conserved,multisubunit protein complex required for gene transcription by RNA polymerase Ⅱ(RNAPⅡ)in all eukaryotes(Allen and Taatjes,2015).This complex,which consists of at least 30 polypeptides,can be divided into four structurally distinct sub-modules including the head,middle,tail,and cyclin-dependent kinase 8(CDK8)
