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Highly Sensitive Detection of Deoxyribonucleic Acid Hybridization Using Au-Gated AlInN/GaN High Electron Mobility Transistor-Based Sensors
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作者 Xiang-Mi Zhan Mei-Lan Ha +7 位作者 Quan Wang Wei Li Hong-Ling Xiao Chun Feng Li-Juan Jiang Cui-Mei Wang Xiao-Liang Wang Zhan-Guo Wang 《Chinese Physics Letters》 SCIE CAS CSCD 2017年第4期75-78,共4页
Gallium nitride- (GaN) based high electron mobility transistors (HEMTs) provide a good platform for biological detection. In this work, both Au-gated AlInN/GaN HEMT and AlGaN/GaN HEMT biosensors are fabricated for... Gallium nitride- (GaN) based high electron mobility transistors (HEMTs) provide a good platform for biological detection. In this work, both Au-gated AlInN/GaN HEMT and AlGaN/GaN HEMT biosensors are fabricated for the detection of deoxyribonucleic acid (DNA) hybridization. The Au-gated AIInN/GaN HEMT biosensor exhibits higher sensitivity in comparison with the AlGaN/GaN HEMT biosensor. For the former, the drain-source current (VDS = 0.5 V) shows a clear decrease of 69μA upon the introduction of 1μmolL^-1 (μM) complimentary DNA to the probe DNA at the sensor area, while for the latter it is only 38 μA. This current reduction is a notable indication of the hybridization. The high sensitivity can be attributed to the thinner barrier of the AlInN/GaN heterostructure, which makes the two-dimensional electron gas channel more susceptible to a slight change of the surface charge. 展开更多
关键词 GAN In highly Sensitive detection of Deoxyribonucleic Acid Hybridization Using Au-Gated AlInN/GaN high Electron Mobility Transistor-Based Sensors
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Highly sensitive detection of NT-proBNP by molecular motor 被引量:1
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作者 Jie Zhang Yao-Gen Shu 《Genes & Diseases》 SCIE 2017年第1期37-40,共4页
FoF1-ATPase is an active rotary motor,and generates three-ATP for each rotation.At saturated substrate concentration,the motor can achieve about 103 r.p.m,which means one motor can generate about 105 ATP molecules dur... FoF1-ATPase is an active rotary motor,and generates three-ATP for each rotation.At saturated substrate concentration,the motor can achieve about 103 r.p.m,which means one motor can generate about 105 ATP molecules during 30 min.Here,we constituted a novel nanodevice with a molecular rotary motor and a“battery”,FoF1-ATPase and chromatophore,and presented a novel method of sandwich type rotary biosensor based on εsubunit with one target-to-one motor,in which one target corresponds 105 ATP molecules as detection signals during 30 min.The target such as NT-proBNP detection demonstrated that this novel nanodevice has potential to be developed into an ultrasensitive biosensor to detect low expressed targets. 展开更多
关键词 Active nanodevice FoF1-ATPase highly sensitive detection Molecular motor NT-PROBNP
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Detection of low-concentration EGFR with a highly sensitive optofluidic resonator
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作者 Jianfeng Shang Hailang Dai +1 位作者 Yun Zou Xianfeng Chen 《Chinese Optics Letters》 SCIE EI CAS CSCD 2017年第9期90-93,共4页
A hollow-core metal-cladding waveguide(HCMW) optofluidic resonator that works based on a free-space coupling technique is designed. An HCMW can excite ultra-high-order modes(UOMs) at the coupled angle, which can b... A hollow-core metal-cladding waveguide(HCMW) optofluidic resonator that works based on a free-space coupling technique is designed. An HCMW can excite ultra-high-order modes(UOMs) at the coupled angle, which can be used as an optofluidic resonator to detect alterations of the epidermal growth factor receptor(EGFR)concentration. Theoretical analysis shows that the UOMs excited in the HCMW have a highly sensitive response to the refractive index(RI) variation of the guiding layer. An EGFR solution with a 0.2 ng/mL alteration is detected, and the RI variation caused by the concentration alteration is about 2.5 × 10^(-3). 展开更多
关键词 detection of low-concentration EGFR with a highly sensitive optofluidic resonator
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