The paper posits that kin sociality and eusociality are derived from the handicap-care principles based on the need-based care to the handicappers from the caregivers for the self-interest of the caregivers. In this p...The paper posits that kin sociality and eusociality are derived from the handicap-care principles based on the need-based care to the handicappers from the caregivers for the self-interest of the caregivers. In this paper, handicap is defined as the difficulty to survive and reproduce independently. Kin sociality is derived from the childhood handicap-care principle where the children are the handicapped children who receive the care from the kin caregivers in the inclusive kin group to survive. The caregiver gives care for its self-interest to reproduce its gene. The individual’s gene of kin sociality contains the handicapped childhood and the caregiving adulthood. Eusociality is derived from the adulthood handicap-care principle where responsible adults are the handicapped adults who give care and receive care at the same time in the interdependent eusocial group to survive and reproduce its gene. Queen bees reproduce, but must receive care from worker bees that work but must rely on queen bees to reproduce. A caregiver gives care for its self-interest to survive and reproduce its gene. The individual’s gene of eusociality contains the handicapped childhood-adulthood and the caregiving adulthood. The chronological sequence of the sociality evolution is individual sociality without handicap, kin sociality with handicapped childhood, and eusociality with handicapped adulthood. Eusociality in humans is derived from bipedalism and the mixed habitat. The chronological sequence of the eusocial human evolution is 1) the eusocial early hominins with bipedalism and the mixed habitat, 2) the eusocial early Homo species with bipedalism, the larger brain, and the open habitat, 3) the eusocial late Homo species with bipedalism, the largest brain, and the unstable habitat, and 4) extended eusocial Homo sapiens with bipedalism, the shrinking brain, omnipresent imagination, and the harsh habitat. The omnipresence of imagination in human culture converts eusociality into extended eusociality with both perception and omnipresent imagination.展开更多
Despite almost half a century of research for theory of mind, its evolutionary origin is largely unknown. This paper proposes that the evolutionary origin of theory of mind starts from the beginning of the human evolu...Despite almost half a century of research for theory of mind, its evolutionary origin is largely unknown. This paper proposes that the evolutionary origin of theory of mind starts from the beginning of the human evolution to form hominins through bipedalism and the mixed habitat. The feet of the early hominins were still adapted for grasping trees rather than walking for long distances and running fast on the ground. The early hominins lived in the mixed habitat of grassy woodland with patches of denser forest, and freshwater springs. The difficulty of walking in the mixed habitat leads to division of labor for the home specialist group (small children, old people, and mothers with small children, and pregnant women) in the safe forest area and the exploration specialist group (young people without the care of small children) in the dangerous open area. The different tasks, attitudes, and mentalities in different specialist groups produce theory of mind as the ability to attribute different mental states to different specialist groups. (Uniformity of mind instead of theory of mind is for generalists without division of labor). The early Homo species with the open habitat developed theory of mind for hunter specialist group and gatherer specialist group. The middle Homo species with complex stone tools developed theory of mind for the cooperative specialist groups in the large production of complex stone tools. The late Homo species with complex social interaction developed theory of mind for mind reading to enhance cooperation and to detect cheaters in complex social interaction. For religion, the unusually harsh Upper Paleolithic Period developed theory of mind for imaginary specialists in terms of supernatural power, guidance, and comfort. Therefore, the three general types of theory of mind are for specialists in division of labor, mind reading in complex social interaction, and imaginary specialists in imaginary division of labor under harsh conditions. Self-awareness in the mirror self-recognition test is also explained.展开更多
If you judge the progress of humanity by Homer Simpson, Paris Hilton, and Girls Gone Wild videos, you might conclude that our evolution has stalled-or even shifted into reverse. Not so, scientists say.……
In order to reveal variation and revolution of NP genes of human avian H5 N1 influenza virus strains, the NP gene of a human avian H5 N1 influenza virus strain in Guangdong was sequenced and the global NP genes of str...In order to reveal variation and revolution of NP genes of human avian H5 N1 influenza virus strains, the NP gene of a human avian H5 N1 influenza virus strain in Guangdong was sequenced and the global NP genes of strains were retrieved. The sequences were analyzed by DNAStar 5.0, and the evolutionary speed was studied with reference to the epidemiological data. It was found that NP genes of 45 strains during 1997-2006 were homologically classified into three groups： strains in 1997-1998, strains in 2004-2005 and strains from 2003 to 2006. There were 35 substitutions in NPs in all strains accounting for a ratio of 7.03% （35/498）. An additional glycoprotein domain （NGT430-432） was found in NP genes in the strains of 2003-2006, the mutation of N370S in GD-01-06 resulted in occurrence of one more glycoprotein domain （NES368-370）. In the synonymous variation, Ks values in NP were 2.03 × 10^-5-2.55 × 10^-5 Nt/d and K. values in NP were 1.58 × 10^-6-3.10 × 10^-6 Nt/d. There didn＇t exist obviously selective pressure. An additional glycoprotein domain in every strain of 2003-2006 and one more in strain GD-01-06 might change the antigenicity of human avian H5 N1 influenza virus. The variation on human avian H5 N1 influenza strains occurred frequently in the natural world, which would result in high probability of human-human transmission along with the natural evolution of the virus.展开更多
Kallikrein 8 （KLK8） is a serine protease functioning in the central nervous system, and essential in many aspects of neuronal activities. Sequence comparison and gene expression analysis among diverse primate specie...Kallikrein 8 （KLK8） is a serine protease functioning in the central nervous system, and essential in many aspects of neuronal activities. Sequence comparison and gene expression analysis among diverse primate species identified a human-specific splice form of KLK8 （type II） with preferential expression in the human brain, which may contribute to the origin of human cognition. To gain insights into the physiological and biochemical role of this novel form, we conducted functional analyses of human type II KLK8. Our results show that type II KLK8 is abundantly expressed in human embryonic stem cells and in embryo brain samples, suggesting a potential role in embryogenesis. There are dramatic expression variations in different individuals and brain regions, which is a reflection of its dynamic role in neural activities. Furthermore, the transcription start site （TSS） of KLK8 is tissue-specific, with a brain-specific TSS found in humans indicating functional specialization. Our in vitro biochemical assay shows that there is a type II-specific intermediate protein form, although the processed end-point enzymes are the same for both type 1 and type II KLK8, suggesting that the emergence of type II KLK8 in the human brain likciy leads to functional modifications of KLK8.展开更多
The successful retrieval of ancient mitochondrial DNA(mtDNA)from Neanderthals provides powerful experimental evidence that clarifies the arguments between the out-of-Africa and multiregional models of evolution.Howeve...The successful retrieval of ancient mitochondrial DNA(mtDNA)from Neanderthals provides powerful experimental evidence that clarifies the arguments between the out-of-Africa and multiregional models of evolution.However,the lack of nuclear DNA from Neanderthal fossils and mtDNA of early modern human fossils dating back to approximately the same time in the Pleistocene constitutes a limitation that may compromise the significance of mtDNA phylogenetic analysis.In this report,we introduce a mitochromic analysis using Neanderthal mtDNA as a foreign transgene and humans as a naturally occurring transgenic species.Forty Neanderthal mtDNA retrievable nuclear fragments were identified by blasting human genome data with Neanderthal mtDNA.Five of the 40 fragments exhibited higher correlation with Neanderthal mtDNA than those with modern human mtDNA.Furthermore,these five nuclear fragments harbor Neanderthal mtDNA-unique haplotypes.Based on the 98%+identity between Neanderthal and modern human mtDNA when compared by groups,we suggest that some of the modern human nuclear fragments retrieved using Neanderthal mtDNA may aid in decoding Neanderthal genetic information,and also may simultaneously demonstrate a close genetic evolutionary relationship between modern humans and Neanderthals.展开更多
The speed,capacity,and strength of artificial intelligence units(AIs)could pose a selfinflicted danger to humanity’s control of its own civilization.In this analysis,three biologically-based components of sentience t...The speed,capacity,and strength of artificial intelligence units(AIs)could pose a selfinflicted danger to humanity’s control of its own civilization.In this analysis,three biologically-based components of sentience that emerged in the course of human evolution are examined:cultural capacity,moral capacity,and religious capacity.The question is posed as to whether some measure of these capacities can be digitized and installed in AIs and so afford protection from their dominance.Theory on the emergence of moral capacity suggests it is most likely to be amenable to digitization and therefore installation in AIs.If so,transfer of that capacity,in creating commonalities between human and AI,may help to protect humanity from being destroyed.We hypothesize that religious thinking and culturally elaborated theological creativity could,in not being easily transferred,afford even more protection by constructing impenetrable barriers between humans and AIs,along real/counterfactual lines.Difficulties in digitizing and installing the three capacities at the foundation of sentience are examined within current discussions of“superalignment”of superintelligent AIs.Human values articulate differently for the three capacities,with different problems and capacities for supervision of superintelligent AIs.展开更多
Aims The Nihewan Basin of North China,considered the cradle of Eastern civilization,contains a set of late Cenozoic strata and artifacts used by Homo ereettvs in the early Pleistocene(〜1.66 Ma to 780 ka)and the crania...Aims The Nihewan Basin of North China,considered the cradle of Eastern civilization,contains a set of late Cenozoic strata and artifacts used by Homo ereettvs in the early Pleistocene(〜1.66 Ma to 780 ka)and the cranial bones and teeth of early H.sapiens from the late middle Pleistocene(~370 to 260 ka).Palynological studies provide an opportunity to explore the living environment of early humans.Methods Ralynological samples from the Hutouliang Section(-603-587 ka)of the Xiaodukou Formation of the Nihewan Basin were treated by heavy liquid flotation.Based on the palynological assemblages from the section,vegetation and climate in the Nihewan Basin were reconstructed.Important Findings The dynamic vegetation changed from temperate needle-and broad-leaved mixed forest-steppe(mainly Picea,Abies,Betula,luglans,Artemisia and Chenopodiaceae)to conifer forest(mainly Pinus,Picea and Abies),which saw the replacement of H.erectus by early H.sapiens.The comparison of the Nihewan Basin with other human sites around the world during the same period reveals that early humans preferred to live in caves,accompanied by relatively open steppe or forest-steppe environments,inhabited by numerous mammals.Therefore,it is inferred that the emergence of dense conifer forest and the disappearance of open steppe environments in the Nihewan Basin at approximately 603-587 ka provide new evidence that early humans followed most mammals to steppe or forest-steppe environments and thus left the Nihewan Basin.These new findings not only enrich our knowledge of early human behavior,such as their diet,migration and settlement,but also fill in gaps in paleovegetation and paleoenvironmental research in the Nihewan Basin during the middle Pleistocene(780-400 ka).展开更多
The prevalence of mobile devices has spurred human mobility to be applied in mobile networking and communications by using network science, in which the temporal evolution of a network topology is of great importance ...The prevalence of mobile devices has spurred human mobility to be applied in mobile networking and communications by using network science, in which the temporal evolution of a network topology is of great importance for protocol design and performance analysis. This paper focuses on link generation in a temporal evolution network. Based on observations revealing the strong correlation between the connection patterns of different time periods, a link generation potential based on historical connections is proposed in this paper, aiming to provide a method for making topological predictions with less randomness. Using MIT Reality dataset, an evaluation of the accuracy of the proposed method was conducted. The experimental results demonstrate the proposal's adequacy in terms of its accuracy.展开更多
The origin of modern humans is one of the fundamental scientific questions that has been widely debated in the international academic community.Since the 1980s,the discussion on this issue has formed two opposing camp...The origin of modern humans is one of the fundamental scientific questions that has been widely debated in the international academic community.Since the 1980s,the discussion on this issue has formed two opposing camps:the""Out of Africa"hypothesis and the"Multiregional Evolution"hypothesis.With the continuous accumulation of new materials and rapid technological advancements in the new century,there have been significant adjustments in the debate over the origin models of modern humans,with materials from the East Asia playing an increasingly important role.This article reviews the major hypotheses and models regarding the origin of modern humans and the evolution of modern behavior,tracing their sources,history,and development.It also provides a comprehensive overview of some of the latest archaeological discoveries and research progress.Furthermore,it discusses the motives and directions for adjusting the models of modern human origins and behavioral evolution,emphasizing the importance of considering a vast amount of archaeological evidence in the discussion of various models and reflecting on the cultural implications of"modernity".The article calls for increased investment in research on the origin of modern humans in China and emphasizes the need to provide a solid Eastern perspective for discussing modern human origin models.展开更多
Clinical translational science:Clinical translational science(CTS)is a new discipline bridging laboratory discoveries and clinical applications.It is normally funded by research grants instead of investment major phar...Clinical translational science:Clinical translational science(CTS)is a new discipline bridging laboratory discoveries and clinical applications.It is normally funded by research grants instead of investment major pharmaceutical companies.It is patient-and populationor community-oriented.Repair of the human展开更多
Increasing Chinese urbanization and industrialization has prompted greater attention to the study of human settlement and the human-land relationship in the fields of geography, architecture, and urban planning. We us...Increasing Chinese urbanization and industrialization has prompted greater attention to the study of human settlement and the human-land relationship in the fields of geography, architecture, and urban planning. We used bibliometric methods and statistical software to review 180 articles on human settlement in 16 Chinese geographical journals. We found that Chinese geographical human settlement research is characterized by the following：（1） Most research focuses on human settlement extension, valuation indicators, models for urban and rural settlements, theoretical exploration and the planning practices of single-factor, human settlement and complex, geographical livability in macro-scale, urban settlement differentiation and ideal patterns in medium scale, the comprehensive evaluation of settlement environment, and the planning of community units in micro-scale, community settlements; socio-cultural investigation and warnings about advancing human settlement.（2） No progress has been made in synthesizing and integrating method systems. PSR models and DPSIR models are used for targeting mechanisms, while the standard settlement evaluation system was composed of physical ＆ economic indicators by questionnaire surveys. On the other hand, spatial clustering based on GIS has been a frequent focus in recent years. Pioneering research on human settlement and theoretical systems within the context of China＇s urbanization and industrialization will provide guidance on the sustainability of Chinese cities and regions. The following five aspects require greater attention：（1） Natural suitability research on human settlement, and a survey of human settlement demands to reflect the range of different demands concerning ecologically suitable settlements in urban environments, the corresponding valuation indicators, systems, and evolution, and the impact of the residents＇ socio-economic attributes.（2） Spatial-temporal evaluation and sustainability research on urban and rural human settlement at various scales, focusing on evolution and spatial differen-tiation at various scales such as city clusters and comparisons between cities, within the cities and communities.（3） Development of theory and technology for human settlement evolution research, including detection technology and methods, data mining measures, and forecasting and emulation of regional and urban human settlement evolution processes, mechanisms and patterns.（4） Research on the control of human settlement that focuses on optimization, patterns, and policies for effective management and development.（5） Estimating the human settlement system service value and establishing suitable human settlement systems, including social, economic, cultural and ecological service values.展开更多
Next-generation RNA sequencing has been successfully used for identification of transcript assembly,evaluation of gene expression levels,and detection of post-transcriptional modifications.Despite these large-scale st...Next-generation RNA sequencing has been successfully used for identification of transcript assembly,evaluation of gene expression levels,and detection of post-transcriptional modifications.Despite these large-scale studies,additional comprehensive RNA-seq data from different subregions of the human brain are required to fully evaluate the evolutionary patterns experienced by the human brain transcriptome.Here,we provide a total of 6.5 billion RNA-seq reads fromdifferent subregions of the human brain.A significant correlation was observed between the levels of alternative splicing and RNA editing,which might be explained by a competition between the molecularmachineries responsible for the splicing and editing of RNA.Younghuman protein-coding genesdemonstrate biased expression to the neocortical and non-neocortical regions during evolution on the lineage leading to humans.Wealso found that a significantly greater number of young human protein-coding genes are expressed in the putamen,a tissue that was also observed to have the highest level of RNA-editing activity.The putamen,which previously received little attention,plays an important role in cognitive ability,and our data suggest a potential contribution of the putamen to human evolution.展开更多
文摘The paper posits that kin sociality and eusociality are derived from the handicap-care principles based on the need-based care to the handicappers from the caregivers for the self-interest of the caregivers. In this paper, handicap is defined as the difficulty to survive and reproduce independently. Kin sociality is derived from the childhood handicap-care principle where the children are the handicapped children who receive the care from the kin caregivers in the inclusive kin group to survive. The caregiver gives care for its self-interest to reproduce its gene. The individual’s gene of kin sociality contains the handicapped childhood and the caregiving adulthood. Eusociality is derived from the adulthood handicap-care principle where responsible adults are the handicapped adults who give care and receive care at the same time in the interdependent eusocial group to survive and reproduce its gene. Queen bees reproduce, but must receive care from worker bees that work but must rely on queen bees to reproduce. A caregiver gives care for its self-interest to survive and reproduce its gene. The individual’s gene of eusociality contains the handicapped childhood-adulthood and the caregiving adulthood. The chronological sequence of the sociality evolution is individual sociality without handicap, kin sociality with handicapped childhood, and eusociality with handicapped adulthood. Eusociality in humans is derived from bipedalism and the mixed habitat. The chronological sequence of the eusocial human evolution is 1) the eusocial early hominins with bipedalism and the mixed habitat, 2) the eusocial early Homo species with bipedalism, the larger brain, and the open habitat, 3) the eusocial late Homo species with bipedalism, the largest brain, and the unstable habitat, and 4) extended eusocial Homo sapiens with bipedalism, the shrinking brain, omnipresent imagination, and the harsh habitat. The omnipresence of imagination in human culture converts eusociality into extended eusociality with both perception and omnipresent imagination.
文摘Despite almost half a century of research for theory of mind, its evolutionary origin is largely unknown. This paper proposes that the evolutionary origin of theory of mind starts from the beginning of the human evolution to form hominins through bipedalism and the mixed habitat. The feet of the early hominins were still adapted for grasping trees rather than walking for long distances and running fast on the ground. The early hominins lived in the mixed habitat of grassy woodland with patches of denser forest, and freshwater springs. The difficulty of walking in the mixed habitat leads to division of labor for the home specialist group (small children, old people, and mothers with small children, and pregnant women) in the safe forest area and the exploration specialist group (young people without the care of small children) in the dangerous open area. The different tasks, attitudes, and mentalities in different specialist groups produce theory of mind as the ability to attribute different mental states to different specialist groups. (Uniformity of mind instead of theory of mind is for generalists without division of labor). The early Homo species with the open habitat developed theory of mind for hunter specialist group and gatherer specialist group. The middle Homo species with complex stone tools developed theory of mind for the cooperative specialist groups in the large production of complex stone tools. The late Homo species with complex social interaction developed theory of mind for mind reading to enhance cooperation and to detect cheaters in complex social interaction. For religion, the unusually harsh Upper Paleolithic Period developed theory of mind for imaginary specialists in terms of supernatural power, guidance, and comfort. Therefore, the three general types of theory of mind are for specialists in division of labor, mind reading in complex social interaction, and imaginary specialists in imaginary division of labor under harsh conditions. Self-awareness in the mirror self-recognition test is also explained.
文摘 If you judge the progress of humanity by Homer Simpson, Paris Hilton, and Girls Gone Wild videos, you might conclude that our evolution has stalled-or even shifted into reverse. Not so, scientists say.……
文摘In order to reveal variation and revolution of NP genes of human avian H5 N1 influenza virus strains, the NP gene of a human avian H5 N1 influenza virus strain in Guangdong was sequenced and the global NP genes of strains were retrieved. The sequences were analyzed by DNAStar 5.0, and the evolutionary speed was studied with reference to the epidemiological data. It was found that NP genes of 45 strains during 1997-2006 were homologically classified into three groups： strains in 1997-1998, strains in 2004-2005 and strains from 2003 to 2006. There were 35 substitutions in NPs in all strains accounting for a ratio of 7.03% （35/498）. An additional glycoprotein domain （NGT430-432） was found in NP genes in the strains of 2003-2006, the mutation of N370S in GD-01-06 resulted in occurrence of one more glycoprotein domain （NES368-370）. In the synonymous variation, Ks values in NP were 2.03 × 10^-5-2.55 × 10^-5 Nt/d and K. values in NP were 1.58 × 10^-6-3.10 × 10^-6 Nt/d. There didn＇t exist obviously selective pressure. An additional glycoprotein domain in every strain of 2003-2006 and one more in strain GD-01-06 might change the antigenicity of human avian H5 N1 influenza virus. The variation on human avian H5 N1 influenza strains occurred frequently in the natural world, which would result in high probability of human-human transmission along with the natural evolution of the virus.
文摘Kallikrein 8 （KLK8） is a serine protease functioning in the central nervous system, and essential in many aspects of neuronal activities. Sequence comparison and gene expression analysis among diverse primate species identified a human-specific splice form of KLK8 （type II） with preferential expression in the human brain, which may contribute to the origin of human cognition. To gain insights into the physiological and biochemical role of this novel form, we conducted functional analyses of human type II KLK8. Our results show that type II KLK8 is abundantly expressed in human embryonic stem cells and in embryo brain samples, suggesting a potential role in embryogenesis. There are dramatic expression variations in different individuals and brain regions, which is a reflection of its dynamic role in neural activities. Furthermore, the transcription start site （TSS） of KLK8 is tissue-specific, with a brain-specific TSS found in humans indicating functional specialization. Our in vitro biochemical assay shows that there is a type II-specific intermediate protein form, although the processed end-point enzymes are the same for both type 1 and type II KLK8, suggesting that the emergence of type II KLK8 in the human brain likciy leads to functional modifications of KLK8.
文摘The successful retrieval of ancient mitochondrial DNA(mtDNA)from Neanderthals provides powerful experimental evidence that clarifies the arguments between the out-of-Africa and multiregional models of evolution.However,the lack of nuclear DNA from Neanderthal fossils and mtDNA of early modern human fossils dating back to approximately the same time in the Pleistocene constitutes a limitation that may compromise the significance of mtDNA phylogenetic analysis.In this report,we introduce a mitochromic analysis using Neanderthal mtDNA as a foreign transgene and humans as a naturally occurring transgenic species.Forty Neanderthal mtDNA retrievable nuclear fragments were identified by blasting human genome data with Neanderthal mtDNA.Five of the 40 fragments exhibited higher correlation with Neanderthal mtDNA than those with modern human mtDNA.Furthermore,these five nuclear fragments harbor Neanderthal mtDNA-unique haplotypes.Based on the 98%+identity between Neanderthal and modern human mtDNA when compared by groups,we suggest that some of the modern human nuclear fragments retrieved using Neanderthal mtDNA may aid in decoding Neanderthal genetic information,and also may simultaneously demonstrate a close genetic evolutionary relationship between modern humans and Neanderthals.
文摘The speed,capacity,and strength of artificial intelligence units(AIs)could pose a selfinflicted danger to humanity’s control of its own civilization.In this analysis,three biologically-based components of sentience that emerged in the course of human evolution are examined:cultural capacity,moral capacity,and religious capacity.The question is posed as to whether some measure of these capacities can be digitized and installed in AIs and so afford protection from their dominance.Theory on the emergence of moral capacity suggests it is most likely to be amenable to digitization and therefore installation in AIs.If so,transfer of that capacity,in creating commonalities between human and AI,may help to protect humanity from being destroyed.We hypothesize that religious thinking and culturally elaborated theological creativity could,in not being easily transferred,afford even more protection by constructing impenetrable barriers between humans and AIs,along real/counterfactual lines.Difficulties in digitizing and installing the three capacities at the foundation of sentience are examined within current discussions of“superalignment”of superintelligent AIs.Human values articulate differently for the three capacities,with different problems and capacities for supervision of superintelligent AIs.
基金This work was supported by the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB26000000).
文摘Aims The Nihewan Basin of North China,considered the cradle of Eastern civilization,contains a set of late Cenozoic strata and artifacts used by Homo ereettvs in the early Pleistocene(〜1.66 Ma to 780 ka)and the cranial bones and teeth of early H.sapiens from the late middle Pleistocene(~370 to 260 ka).Palynological studies provide an opportunity to explore the living environment of early humans.Methods Ralynological samples from the Hutouliang Section(-603-587 ka)of the Xiaodukou Formation of the Nihewan Basin were treated by heavy liquid flotation.Based on the palynological assemblages from the section,vegetation and climate in the Nihewan Basin were reconstructed.Important Findings The dynamic vegetation changed from temperate needle-and broad-leaved mixed forest-steppe(mainly Picea,Abies,Betula,luglans,Artemisia and Chenopodiaceae)to conifer forest(mainly Pinus,Picea and Abies),which saw the replacement of H.erectus by early H.sapiens.The comparison of the Nihewan Basin with other human sites around the world during the same period reveals that early humans preferred to live in caves,accompanied by relatively open steppe or forest-steppe environments,inhabited by numerous mammals.Therefore,it is inferred that the emergence of dense conifer forest and the disappearance of open steppe environments in the Nihewan Basin at approximately 603-587 ka provide new evidence that early humans followed most mammals to steppe or forest-steppe environments and thus left the Nihewan Basin.These new findings not only enrich our knowledge of early human behavior,such as their diet,migration and settlement,but also fill in gaps in paleovegetation and paleoenvironmental research in the Nihewan Basin during the middle Pleistocene(780-400 ka).
基金supported by the National Natural Science Foundation of China(Grant No.61300183)the National Science Fund for Distinguished Young Scholars in China(Grant No.61425012)
文摘The prevalence of mobile devices has spurred human mobility to be applied in mobile networking and communications by using network science, in which the temporal evolution of a network topology is of great importance for protocol design and performance analysis. This paper focuses on link generation in a temporal evolution network. Based on observations revealing the strong correlation between the connection patterns of different time periods, a link generation potential based on historical connections is proposed in this paper, aiming to provide a method for making topological predictions with less randomness. Using MIT Reality dataset, an evaluation of the accuracy of the proposed method was conducted. The experimental results demonstrate the proposal's adequacy in terms of its accuracy.
基金This research was supported by the National Social Science Fund of China(21@WTKO01&19AKG001)the Fundamental Research Funds for the Central Universities(2022QNYL03)"The Roots of Chinese civilization of Zhengzhou University"(XKZDJC202006).
文摘The origin of modern humans is one of the fundamental scientific questions that has been widely debated in the international academic community.Since the 1980s,the discussion on this issue has formed two opposing camps:the""Out of Africa"hypothesis and the"Multiregional Evolution"hypothesis.With the continuous accumulation of new materials and rapid technological advancements in the new century,there have been significant adjustments in the debate over the origin models of modern humans,with materials from the East Asia playing an increasingly important role.This article reviews the major hypotheses and models regarding the origin of modern humans and the evolution of modern behavior,tracing their sources,history,and development.It also provides a comprehensive overview of some of the latest archaeological discoveries and research progress.Furthermore,it discusses the motives and directions for adjusting the models of modern human origins and behavioral evolution,emphasizing the importance of considering a vast amount of archaeological evidence in the discussion of various models and reflecting on the cultural implications of"modernity".The article calls for increased investment in research on the origin of modern humans in China and emphasizes the need to provide a solid Eastern perspective for discussing modern human origin models.
文摘Clinical translational science:Clinical translational science(CTS)is a new discipline bridging laboratory discoveries and clinical applications.It is normally funded by research grants instead of investment major pharmaceutical companies.It is patient-and populationor community-oriented.Repair of the human
基金National Natural Science Foundation of China,No.41230632,No.41301110,No.41501119 Zhejiang Provincial Natural Science Foundation of China,No.LY16D010008,No.Y14D010007
文摘Increasing Chinese urbanization and industrialization has prompted greater attention to the study of human settlement and the human-land relationship in the fields of geography, architecture, and urban planning. We used bibliometric methods and statistical software to review 180 articles on human settlement in 16 Chinese geographical journals. We found that Chinese geographical human settlement research is characterized by the following：（1） Most research focuses on human settlement extension, valuation indicators, models for urban and rural settlements, theoretical exploration and the planning practices of single-factor, human settlement and complex, geographical livability in macro-scale, urban settlement differentiation and ideal patterns in medium scale, the comprehensive evaluation of settlement environment, and the planning of community units in micro-scale, community settlements; socio-cultural investigation and warnings about advancing human settlement.（2） No progress has been made in synthesizing and integrating method systems. PSR models and DPSIR models are used for targeting mechanisms, while the standard settlement evaluation system was composed of physical ＆ economic indicators by questionnaire surveys. On the other hand, spatial clustering based on GIS has been a frequent focus in recent years. Pioneering research on human settlement and theoretical systems within the context of China＇s urbanization and industrialization will provide guidance on the sustainability of Chinese cities and regions. The following five aspects require greater attention：（1） Natural suitability research on human settlement, and a survey of human settlement demands to reflect the range of different demands concerning ecologically suitable settlements in urban environments, the corresponding valuation indicators, systems, and evolution, and the impact of the residents＇ socio-economic attributes.（2） Spatial-temporal evaluation and sustainability research on urban and rural human settlement at various scales, focusing on evolution and spatial differen-tiation at various scales such as city clusters and comparisons between cities, within the cities and communities.（3） Development of theory and technology for human settlement evolution research, including detection technology and methods, data mining measures, and forecasting and emulation of regional and urban human settlement evolution processes, mechanisms and patterns.（4） Research on the control of human settlement that focuses on optimization, patterns, and policies for effective management and development.（5） Estimating the human settlement system service value and establishing suitable human settlement systems, including social, economic, cultural and ecological service values.
基金supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences(XDB13000000)the National Natural Science Foundation of China(31271339,31301042).
文摘Next-generation RNA sequencing has been successfully used for identification of transcript assembly,evaluation of gene expression levels,and detection of post-transcriptional modifications.Despite these large-scale studies,additional comprehensive RNA-seq data from different subregions of the human brain are required to fully evaluate the evolutionary patterns experienced by the human brain transcriptome.Here,we provide a total of 6.5 billion RNA-seq reads fromdifferent subregions of the human brain.A significant correlation was observed between the levels of alternative splicing and RNA editing,which might be explained by a competition between the molecularmachineries responsible for the splicing and editing of RNA.Younghuman protein-coding genesdemonstrate biased expression to the neocortical and non-neocortical regions during evolution on the lineage leading to humans.Wealso found that a significantly greater number of young human protein-coding genes are expressed in the putamen,a tissue that was also observed to have the highest level of RNA-editing activity.The putamen,which previously received little attention,plays an important role in cognitive ability,and our data suggest a potential contribution of the putamen to human evolution.
