In this manuscript, we describe the novel method for preparing the microcapsules containing α-tocopherol oil droplets as the first core material, calcium chloride powder as the second core material and the fine water...In this manuscript, we describe the novel method for preparing the microcapsules containing α-tocopherol oil droplets as the first core material, calcium chloride powder as the second core material and the fine water droplets as the third core material by the interfacial condensation reaction between hydroxyl propyl methyl cellulose and tannic acid. The interfacial condensation reaction was performed between hydroxyl propyl methyl cellulose dissolved in the continuous water phase and tannic acid dissolved in the inner fine water droplets as the third core material. The calcium chloride powder as the second core material was dispersed in the α-tocopherol oil droplet as the first core material beforehand. The α-tocopherol oil containing the second and the third core materials was dispersed in the continuous water phase to form the [(S + W)/O/W] emulsion. The α-tocopherol oil as the first core material was microencapsulated satisfactorily and the contents of the second core material were increased with the concentration of stearic acid as the oil soluble stabilizer. The mechanical strength of microcapsules increased with the concentration of hydroxyl propyl methyl cellulose. Thermal energy could be released by breaking the microcapsules in water and by dissolving calcium chloride in the continuous water phase.展开更多
The surface of nano SiO 2 was modified by being encapsulated with hydroxy propyl methyl cellulose (HPMC), and then co grafted with acrylates. The grafting conditions, such as pH of the medium, and initiator conce...The surface of nano SiO 2 was modified by being encapsulated with hydroxy propyl methyl cellulose (HPMC), and then co grafted with acrylates. The grafting conditions, such as pH of the medium, and initiator concentration have been studied. The modified nano SiO 2 particles were characterized by TEM, DSC and FT IR spectra. TEM images show that the surface of the nano particles has been successfully modified by a thick layer of film like polymer in this way. The DSC results show that the decomposition temperature of modified nano particles of SiO 2 is 90 ℃ higher than that of grafted on polymer. According to the FT IR spectra, it is convinced that poly methyl methacrylate (PMMA) and poly acrylic butyl ester (PBA) were co grafted onto the surface of nano SiO 2.展开更多
Objective: To formulate and evaluate anti-asthmatic drug montelukast in mucoadhesive buccal patches. Methods:Buccal patches were formulated by using different hydrophilic polymers by solvent casting technique. Buccal ...Objective: To formulate and evaluate anti-asthmatic drug montelukast in mucoadhesive buccal patches. Methods:Buccal patches were formulated by using different hydrophilic polymers by solvent casting technique. Buccal patches were evaluated by seven physical appearances, in addition toin vitro drug release study. Results: All patches were uniform and translucent, and had smooth surface. In vitro release studies were conducted for montelukast buccal patches proved that release in the range of 75.26%-92.30% in 8 h. Emission of montelukast from all patches simulated zero order and diffusion mechanism. Finally it can be concluded that F3, F15 and F16 are the best formulation. Conclusions: The investigation concluded that patch of 5 mg of montelukast sodium were formulated by using sodium alginate with sodium carboxy methyl cellulose, hydroxy propyl methyl cellulose K100M with sodium carboxy methyl cellulose, and hydroxy propyl methyl cellulose K100M with sodium alginate (F3, F15 and F16 formulations) were the best formulations.展开更多
文摘In this manuscript, we describe the novel method for preparing the microcapsules containing α-tocopherol oil droplets as the first core material, calcium chloride powder as the second core material and the fine water droplets as the third core material by the interfacial condensation reaction between hydroxyl propyl methyl cellulose and tannic acid. The interfacial condensation reaction was performed between hydroxyl propyl methyl cellulose dissolved in the continuous water phase and tannic acid dissolved in the inner fine water droplets as the third core material. The calcium chloride powder as the second core material was dispersed in the α-tocopherol oil droplet as the first core material beforehand. The α-tocopherol oil containing the second and the third core materials was dispersed in the continuous water phase to form the [(S + W)/O/W] emulsion. The α-tocopherol oil as the first core material was microencapsulated satisfactorily and the contents of the second core material were increased with the concentration of stearic acid as the oil soluble stabilizer. The mechanical strength of microcapsules increased with the concentration of hydroxyl propyl methyl cellulose. Thermal energy could be released by breaking the microcapsules in water and by dissolving calcium chloride in the continuous water phase.
基金ProjectsupportedbytheNaturalScienceFoundationofAnhuiEducationalCommittee (No .2 0 0 1KJ0 96),theSpecialScienceResearchFoundationofAnhuiNormalUniversity (No .2000ZX10)andtheNaturalScienceImportantFoundationofAnhuiProvince (No .0 10 2 2 0 0 7)
文摘The surface of nano SiO 2 was modified by being encapsulated with hydroxy propyl methyl cellulose (HPMC), and then co grafted with acrylates. The grafting conditions, such as pH of the medium, and initiator concentration have been studied. The modified nano SiO 2 particles were characterized by TEM, DSC and FT IR spectra. TEM images show that the surface of the nano particles has been successfully modified by a thick layer of film like polymer in this way. The DSC results show that the decomposition temperature of modified nano particles of SiO 2 is 90 ℃ higher than that of grafted on polymer. According to the FT IR spectra, it is convinced that poly methyl methacrylate (PMMA) and poly acrylic butyl ester (PBA) were co grafted onto the surface of nano SiO 2.
文摘Objective: To formulate and evaluate anti-asthmatic drug montelukast in mucoadhesive buccal patches. Methods:Buccal patches were formulated by using different hydrophilic polymers by solvent casting technique. Buccal patches were evaluated by seven physical appearances, in addition toin vitro drug release study. Results: All patches were uniform and translucent, and had smooth surface. In vitro release studies were conducted for montelukast buccal patches proved that release in the range of 75.26%-92.30% in 8 h. Emission of montelukast from all patches simulated zero order and diffusion mechanism. Finally it can be concluded that F3, F15 and F16 are the best formulation. Conclusions: The investigation concluded that patch of 5 mg of montelukast sodium were formulated by using sodium alginate with sodium carboxy methyl cellulose, hydroxy propyl methyl cellulose K100M with sodium carboxy methyl cellulose, and hydroxy propyl methyl cellulose K100M with sodium alginate (F3, F15 and F16 formulations) were the best formulations.
