The 2018 Joint International Congress of ILTS,ELITA and LICAGE were held in Lisbon,Portugal on May 23–26,2018.The exciting and innovative program brought together 1144 experts in liver transplantation(LT)such as surg...The 2018 Joint International Congress of ILTS,ELITA and LICAGE were held in Lisbon,Portugal on May 23–26,2018.The exciting and innovative program brought together 1144 experts in liver transplantation(LT)such as surgeons,physicians or basic scientists from 61 countries.The presentations included 110 invited speakers,181 oral presentations,and 545 posters.This editorial highlights some of the most innovative and impactful presentations in展开更多
<b>Objective:</b> The objective is to<span "=""> compare a regular ovitrap versus an innovated larvitrap for monitoring <i>Aedes</i> spp. populations. <b>Materials an...<b>Objective:</b> The objective is to<span "=""> compare a regular ovitrap versus an innovated larvitrap for monitoring <i>Aedes</i> spp. populations. <b>Materials and Methods</b></span><b>:</b><span "=""> A total of 20 regular ovitraps and 20 innovated larvitraps were placed in pairs in 20 houses from the 5 de Febrero neighborhood in Tapachula, Chiapas, Mexico. The innovation consisted in the incorporation of a valve in the lower part of a half tire to drain the contents in a 2 L collection container. The evaluation was carried out during five weeks, collecting eggs and larvae from the ovitraps and innovated larvitraps, respectively. Positivity indexes and insectary production of adult <i>Aedes</i> spp. mosquitoes were compared by collection type. <b>Results</b></span><b>:</b><span "=""> Average positivity index for the five weeks period were 60% for ovitraps and 91.25% for innovated larvitraps. During the five weeks, 4043 <i>Ae.</i> <i>aegypti</i> and 703 <i>Ae.</i> <i>albopictus</i> adult mosquitoes were produced in the insectary from the eggs collected from ovitraps, while from innovated larvitraps were 9014 <i>Ae.</i> <i>aegypti</i>, 1205 <i>Ae.</i> <i>albopictus</i>, and 15 <i>Culex</i> spp. <b>Conclusion</b></span><b>:</b><span "=""> Collection by the innovated larvitrap was more efficient, collecting 3.56 times more <i>Ae.</i> <i>aegypti</i> than with ovitraps, using approximately the same effort in time for replacing the filter paper from traditional 1 L ovitraps. Since the logistics for the storage and placement of larvitraps may still be a disadvantage in comparison with ovitraps, their use could be specifically intended in sentinel sites for mosquito population monitoring for entomological surveillance purposes.展开更多
Senior corporate managers＇ innovation ability and spirit are very important in the growth process of corporate business development. This paper focuses on the innovation capacities of the senior corporate managers of...Senior corporate managers＇ innovation ability and spirit are very important in the growth process of corporate business development. This paper focuses on the innovation capacities of the senior corporate managers of listed companies in China and the complex relationship between firm performance and the operating environment to study and analyze the management and development of Chinese enterprises. Through relevant theoretical analysis and development of research hypotheses using the A-shares in Shanghai and Shenzhen listed companies announced in 2007 and 2008, the authors design an empirical model. The study found that in Chinese listed companies, the higher the innovation spirit of senior corporate managers, the better their business performances; the stronger the dynamic and complexity of the operating environment, the more the corporate managers＇ innovation ability will be developed.展开更多
We have recently developed a systematic method for the study on the inheritance of resistance to sheath blight. The key of the system is an innovated method of inoculation and investigation along with the employment o...We have recently developed a systematic method for the study on the inheritance of resistance to sheath blight. The key of the system is an innovated method of inoculation and investigation along with the employment of the permanent population. This paper reported the procedure of the system and the result of its verification.展开更多
In 2008, two governmental committees presented their conclusions on strengthening the role of the private building sector in building control. In 2011, three new studies were commissioned by the government to address ...In 2008, two governmental committees presented their conclusions on strengthening the role of the private building sector in building control. In 2011, three new studies were commissioned by the government to address perceived problems. One of them was an integral study, executed by ERB （Foundation Expertcentre Regulations in Building）, RIGO （Research Institute for Real Estate） and TNO （Research Institute for Applied Technologies）, to innovate the whole building regulations system. It led to proposals to redefine responsibility and liability for all parties. This study states that by an effort of yearly ￡100 million, unnecessary costs up to ￡l billion can be avoided and a real quality push will take place in the building and real estate markets. The goals to reach are to minimize the administrative burden for the building owner and to enforce the construction industry to build conforming to the regulations. This paper discusses the ERB study and the given proposals. The ERB study demonstrated that a quality push is needed which potential will lead to less costs for building owners. It also shows that proven solutions, part of the regulations, might be of help for all parties involved.展开更多
TOWARDS the end of last year, a Chinese magazine released a list of the country’s buzzwords of 2006. It was no surprise that ＂Innovation＂ ranked third. That year witnessed a nationwide campaign of sci-tech innova...TOWARDS the end of last year, a Chinese magazine released a list of the country’s buzzwords of 2006. It was no surprise that ＂Innovation＂ ranked third. That year witnessed a nationwide campaign of sci-tech innovation that reached unprecedented heat. And this time, the flames spread inland, to places like the frontier province of Yunnan.展开更多
This study analyses the role played by organizational ambidexterity and open innovation in innovation outputs,considering business units with different levels of technological intensity(medium-high and high tech,and m...This study analyses the role played by organizational ambidexterity and open innovation in innovation outputs,considering business units with different levels of technological intensity(medium-high and high tech,and medium-low and low tech)for countries with different inno-vation profiles.The countries considered in this paper are i)Estonia and Slovenia as innovation followers;i)Slovakia,Hungary,Spain,Czech Republic,Italy,Portugal,Norway,and Croatia as moderate innovators;and ii)Bulgaria,Lithuania and Romania as modest innovators.In the empirical approach,the research hypotheses arise from the literature review and are tested using secondary data collected from the Community Innovation Survey(CIS)201o.The conceptual model is tested using the logistic regression method,which indicates suitable accuracy and reliability for empirical testing purposes.The evidence reveals that for innovation followers,ambidexterity has a greater influence on the practice of eco-innovation,marketing innovation,and product innovation.For moderate innovators,ambidexterity has a greater influence on the practice of product innovation,process innovation,and eco-innovation.Concerning modest in-novators,ambidexterity has a greater influence on the practice of product innovation,process innovation,and eco-innovation.With regard to open innovation,for innovation followers,this has a negative influence on product innovation in medium-high and high-tech companies.For moderate innovators,open innovation has a greater influence in process,organizational,and eco-innovation.In the case of modest innovators,open innovation is more significant for innovation outputs in product,organizational,and marketing innovation.Size is not always positively related to innovation outputs.展开更多
The Porter Hypothesis,proposed by Michael E.Porter,suggests that stringent environmental regulations can enhance corporate innovation and competitiveness,challenging the traditional view that regulations increase busi...The Porter Hypothesis,proposed by Michael E.Porter,suggests that stringent environmental regulations can enhance corporate innovation and competitiveness,challenging the traditional view that regulations increase business costs.It argues that regulations motivate firms to innovate,leading to improved productivity,cost reductions,and new market opportunities.However,there are proponents and critics in academia regarding the hypothesis.Supporters claim regulations change corporate behavior,reducing agency costs and boosting research and development.Critics argue that if win-win situations exist,businesses would naturally pursue them without regulatory incentives.Key challenges in proving or refuting the hypothesis include its various versions,the difficulty in quantifying innovation and competitiveness,the complex interplay between regulation,innovation,and competitiveness,and the varying impacts across industries and regions.Additionally,the effects may require a long time to manifest,and the hypothesis’s applicability is influenced by evolving environmental policies and market environments.Despite mixed empirical findings,the Porter Hypothesis provides a valuable framework for understanding the relationships among environmental regulation,innovation,and competitiveness,but its validation requires a more comprehensive assessment.展开更多
The pursuit of improved quality of life standards has significantly influenced the contemporary mining model in the 21st century.This era is witnessing an unprecedented transformation driven by pressing concerns relat...The pursuit of improved quality of life standards has significantly influenced the contemporary mining model in the 21st century.This era is witnessing an unprecedented transformation driven by pressing concerns related to sustainability,climate change,the just energy transition,dynamic operating environments,and complex social challenges.Such transitions present both opportunities and obstacles.The aim of this study is to provide an extensive literature review on energy transition to identify the challenges and strategies associated with navigating transformations in energy systems.Understanding these transformations is particularly critical in the face of the severe consequences of global warming,where an accelerated energy transition is viewed as a universal remedy.Adopting a socio-technological systems perspective,specifically through the application of Actor Network Theory(ANT),this research provides a theoretical foundation while categorising challenges into five distinct domains and outlining strategies across these different dimensions.These insights are specifically tailored for emerging market countries to effectively navigate energy transition while fostering the development of resilient societies.Furthermore,our findings highlight that energy transition encompasses more than a mere technological shift;it entails fundamental changes in various systemic socio-economic imperatives.Through focusing on the role of social structures in transitions,this study makes a significant and innovative contribution to ANT,which has historically been criticised for its limited acknowledgement of social structures.Consequently,we propose an emerging market energy transition framework,which not only addresses technological aspects,but also integrates social considerations.This framework paves the way for future research and exploration of energy transition dynamics.The outcomes of this study offer valuable insights to policymakers,researchers,and practitioners engaged in the mining industry,enabling them to comprehend the multifaceted challenges involved and providing practical strategies for effective resolution.Through incorporating the social dimension into the analysis,we enhance the understanding of the complex nature of energy system transformations,facilitating a more holistic approach towards achieving sustainable and resilient energy transitions in emerging markets and beyond.展开更多
Metabolic dysfunction-associated steatotic liver disease(MASLD),once known as non-alcoholic fatty liver disease(NAFLD),represents a spectrum of liver disorders characterized by lipid accumulation within hepatocytes.Th...Metabolic dysfunction-associated steatotic liver disease(MASLD),once known as non-alcoholic fatty liver disease(NAFLD),represents a spectrum of liver disorders characterized by lipid accumulation within hepatocytes.The redefinition of NAFLD in 2023 marked a significant reposition in terminology,emphasizing a broader understanding of liver steatosis and its associated risks.MASLD is now recognized as a major risk factor for liver cirrhosis,hepatocellular carcinoma,and systemic complications such as cardiovascular diseases or systemic inflammation.Diagnostic challenges arise,particularly in identifying MASLD in lean individuals,necessitating updated diagnostic protocols and investing in non-invasive diagnostic tools.Therapeutically,there is an urgent need for effective treatments targeting MASLD,with emerging pharmacological options focusing on,among others,carbohydrate and lipid metabolism.Additionally,understanding the roles of bile acid metabolism,the microbiome,and dietary interventions in MASLD pathogenesis and management holds promise for innovative therapeutic approaches.There is a strong need to emphasize the importance of collaborative efforts in understanding,diagnosing,and managing MASLD to improve physicians’approaches and patient outcomes.展开更多
The exploration of the way"mass entrepreneurship and innovation"(MEI)education influences students'aspirations to become entrepreneurs has grown into an important area of analysis in studies related to h...The exploration of the way"mass entrepreneurship and innovation"(MEI)education influences students'aspirations to become entrepreneurs has grown into an important area of analysis in studies related to higher education.This research intends to examine the consequences of MEI education on students'tendency towards entrepreneurship,and to put forward methods for augmenting the teaching of innovation and entrepreneurship in private higher educational establishments.To achieve this objective,questionnaires and semi-structured interviews were employed in the study,which involved a total of 197 students and five education experts.The statistical analysis of the questionnaire data revealed that MEI education was positively related to students'entrepreneurial intentions,and that both entrepreneurial experience and family entrepreneurial background played moderating roles in this relationship.The interview findings indicated that private universities could enhance educational reforms by designing talent training programs,developing diversified curricula,and developing more professional entrepreneurial platforms to encourage students'entrepreneurial intentions.This study offers fresh insights for improving and perfecting the mechanism of innovation and entrepreneurship education in private universities.展开更多
The optimization of government subsidies to enhance the efficiency of coal companies’green transformation constitutes a critical component in the pursuit of global sustainability.We investigate the influence mechanis...The optimization of government subsidies to enhance the efficiency of coal companies’green transformation constitutes a critical component in the pursuit of global sustainability.We investigate the influence mechanism of government subsidies on the green transformation using data from the listed coal companies in China from 2007 to 2022.According to our findings and hypothesis testing,previous government subsidies did not have a significant direct impact on coal companies’green transformation.Nevertheless,government subsidies can help coal companies transition to greener practices by promoting innovative green initiatives.Furthermore,we confirmed an indirect route:that government subsidies enable the adoption of low-carbon initiatives,which in turn could facilitate the transition of coal companies towards green practices.In addition,we discovered that the coal company’s digitization will improve this indirect route.Thus,we propose increasing the effectiveness of government subsidies in facilitating coal companies’transition to green practices by focusing on technological advancements and enhancing company digitalization.展开更多
The world is facing dramatic challenges related to environmental sustainability at an accelerating pace.In this context,the field of economic geography(EG)has been playing an important role in understanding both the s...The world is facing dramatic challenges related to environmental sustainability at an accelerating pace.In this context,the field of economic geography(EG)has been playing an important role in understanding both the socioeconomic and technological dimensions of these challenges,as it deals with a variety of complementary notions and perspectives.Departing from this lens,our aim is to explore a conceptual framework that can help us to understand environmental changes relating to multi-dimensional territorial development,notably in eco-nomic contexts where inequality is high,and stratification based on hierarchies regulate social and economic life.Based on the territory concept,we propose the original notion of a hierarchical regional innovation system(HRIS)that emphasises the pervasive role of hierarchies(powers)in regional innovation systems and illustrate its value with evidence and case studies from extant literature on sustainability transitions.The HRIS can help us understand and promote development paths considering the contribution of inclusive eco-innovations(another original conceptual amalgam).Through some empirical cases from other studies in low-carbon transitions,we show the application of the HRIS(and inclusive eco-innovation)framework.In conclusion,we provide incen-tives to explore new regional innovation systems,alongside the HRIS,adapted to different regions worldwide and centred on the inclusiveness of people and places.展开更多
As the world continues to search for innovative therapeutic solutions,the field of natural medicines has emerged as a vibrant area of research.The potential of natural products to treat a wide range of diseases,couple...As the world continues to search for innovative therapeutic solutions,the field of natural medicines has emerged as a vibrant area of research.The potential of natural products to treat a wide range of diseases,coupled with the relatively low sideeffects of such products,has captured the attention of scientists,clinicians,and the general public alike.This Special Issue on Natural Medicine aims to present the latest advancements in this exciting field,highlighting both fundamental research and clinical applications.The collection of articles in this Special Issue covers a broad spectrum of topics,ranging from medicinal chemistry to biological mechanisms,and from the study of single botanic compounds to complex plant formulas.We are particularly pleased to include a comprehensive review by Yi Wang et al.on the bioactivities,mechanisms,production,and potential application of bile acids in preventing and treating infectious diseases.This review not only summarizes the current landscape of bile acids research but also highlights several promising compounds for future investigations,such as the recent interest in ursodeoxycholic acid.In a related topic,Shishan Yu’s team has developed artificial bear bile using synthetic chemistry and enzyme engineering,providing a sustainable substitute for natural bear bile.This innovation meets medical needs while addressing animal welfare issues,representing a notable progression in the field.展开更多
Al is revolutionizing the current paradigm of pharmaceutical research,addressing the challenges encountered at all stages of the process.Al driven drug discovery is based on biomedical big data and new algorithms to i...Al is revolutionizing the current paradigm of pharmaceutical research,addressing the challenges encountered at all stages of the process.Al driven drug discovery is based on biomedical big data and new algorithms to identify drug targets,screen and optimize active compounds,analyze drug properties,and facilitate drug production and quality control.On this basis,we are organize this special issue entitled“Innovative Pharmaceutical Research Driven by Al”,to collect Research articles,Review papers,and Short communications,facilitating pharmaceutical research.展开更多
Firms are embedded in complex networks,where diverse ideas combine and generate new ideas.Shareholders of firms are of-ten seen as critical external resources that have significant influence on firm innovation.The cur...Firms are embedded in complex networks,where diverse ideas combine and generate new ideas.Shareholders of firms are of-ten seen as critical external resources that have significant influence on firm innovation.The current literature tends to focus on the rela-tionship between firms and their shareholders,while paying less attention to the connections between firms with the same shareholders.This article identifies two types of network spillover effects,intra-city network effect and inter-city network effect,by visualizing the co-ownership networks in China’s electric vehicle(EV)industry.We find that firms with the same shareholders,which are defined as co-owned EV firms,are more innovative than non-co-owned ones.Furthermore,there are two dominant types of firm co-ownership ties formed by corporate and financial institution shareholders.While corporate shareholders help exploiting local tacit knowledge,financial institutions are more active in bridging inter-city connections.The conclusion is confirmed at both firm and city levels.This paper theor-izes the firm co-ownership network as a new form of institutional proximity and tested the result empirically.For policy consideration,we have emphasized the importance of building formal or informal inter-firm network,and the government should further enhance the knowledge flow channel by institutional construction.展开更多
Since its inception,Animal Models and Experimental Medicine(AMEM)has received 632 articles in total from 52 countries and regions includ-ing China,Iran,the United States,India,Nigeria,Israel,Germany,Iraq,Italy,Japan,A...Since its inception,Animal Models and Experimental Medicine(AMEM)has received 632 articles in total from 52 countries and regions includ-ing China,Iran,the United States,India,Nigeria,Israel,Germany,Iraq,Italy,Japan,Australia,Bangladesh,Belgium,Brazil,and Canada,among others.AMEM has become an important international exchange plat-form for innovative research achievements in the field of laboratory animal science and basic medicine.展开更多
The continued expansion of the world population,increasingly inconsistent climate and shrinking agricultural resources present major challenges to crop breeding.Fortunately,the increasing ability to discover and manip...The continued expansion of the world population,increasingly inconsistent climate and shrinking agricultural resources present major challenges to crop breeding.Fortunately,the increasing ability to discover and manipulate genes creates new opportunities to develop more productive and resilient cultivars.Many genes have been described in papers as being beneficial for yield increase.However,few of them have been translated into increased yield on farms.In contrast,commercial breeders are facing gene decidophobia,i.e.,puzzled about which gene to choose for breeding among the many identified,a huge chasm between gene discovery and cultivar innovation.The purpose of this paper is to draw attention to the shortfalls in current gene discovery research and to emphasise the need to align with cultivar innovation.The methodology dictates that genetic studies not only focus on gene discovery but also pay good attention to the genetic backgrounds,experimental validation in relevant environments,appropriate crop management,and data reusability.The close of the gaps should accelerate the application of molecular study in breeding and contribute to future global food security.展开更多
This paper presents a systematic methodology for analyzing and optimizing an innovative antenna mount designed for phased array antennas, implemented through a novel 2-PSS&1-RR circular-rail parallel mechanism. In...This paper presents a systematic methodology for analyzing and optimizing an innovative antenna mount designed for phased array antennas, implemented through a novel 2-PSS&1-RR circular-rail parallel mechanism. Initially, a comparative motion analysis between the 3D model of the mount and its full-scale prototype is conducted to validate effectiveness. Given the inherent complexity, a kinematic mapping model is established between the mount and the crank-slider linkage, providing a guiding framework for subsequent analysis and optimization. Guided by this model, feasible inverse and forward solutions are derived, enabling precise identification of stiffness singularities. The concept of singularity distance is thus introduced to reflect the structural stiffness of the mount. Subsequently, also guided by the mapping model, a heuristic algorithm incorporating two backtracking procedures is developed to reduce the mount's mass. Additionally, a parametric finite-element model is employed to explore the relation between singularity distance and structural stiffness. The results indicate a significant reduction(about 16%) in the antenna mount's mass through the developed algorithm, while highlighting the singularity distance as an effective stiffness indicator for this type of antenna mount.展开更多
基金supported by grants from China Postdoctoral Science Foundation(2017M610374)National Natural Science Foundation of China(81470891)+2 种基金Science and Technology Bureau of Zhejiang Province,China(2016C33145)Innovative Research Groups of the National Natural Science Foundation of China(81421062)the Fundamental Research Funds for the Central Universities(2018FZA7003)
文摘The 2018 Joint International Congress of ILTS,ELITA and LICAGE were held in Lisbon,Portugal on May 23–26,2018.The exciting and innovative program brought together 1144 experts in liver transplantation(LT)such as surgeons,physicians or basic scientists from 61 countries.The presentations included 110 invited speakers,181 oral presentations,and 545 posters.This editorial highlights some of the most innovative and impactful presentations in
文摘<b>Objective:</b> The objective is to<span "=""> compare a regular ovitrap versus an innovated larvitrap for monitoring <i>Aedes</i> spp. populations. <b>Materials and Methods</b></span><b>:</b><span "=""> A total of 20 regular ovitraps and 20 innovated larvitraps were placed in pairs in 20 houses from the 5 de Febrero neighborhood in Tapachula, Chiapas, Mexico. The innovation consisted in the incorporation of a valve in the lower part of a half tire to drain the contents in a 2 L collection container. The evaluation was carried out during five weeks, collecting eggs and larvae from the ovitraps and innovated larvitraps, respectively. Positivity indexes and insectary production of adult <i>Aedes</i> spp. mosquitoes were compared by collection type. <b>Results</b></span><b>:</b><span "=""> Average positivity index for the five weeks period were 60% for ovitraps and 91.25% for innovated larvitraps. During the five weeks, 4043 <i>Ae.</i> <i>aegypti</i> and 703 <i>Ae.</i> <i>albopictus</i> adult mosquitoes were produced in the insectary from the eggs collected from ovitraps, while from innovated larvitraps were 9014 <i>Ae.</i> <i>aegypti</i>, 1205 <i>Ae.</i> <i>albopictus</i>, and 15 <i>Culex</i> spp. <b>Conclusion</b></span><b>:</b><span "=""> Collection by the innovated larvitrap was more efficient, collecting 3.56 times more <i>Ae.</i> <i>aegypti</i> than with ovitraps, using approximately the same effort in time for replacing the filter paper from traditional 1 L ovitraps. Since the logistics for the storage and placement of larvitraps may still be a disadvantage in comparison with ovitraps, their use could be specifically intended in sentinel sites for mosquito population monitoring for entomological surveillance purposes.
文摘Senior corporate managers＇ innovation ability and spirit are very important in the growth process of corporate business development. This paper focuses on the innovation capacities of the senior corporate managers of listed companies in China and the complex relationship between firm performance and the operating environment to study and analyze the management and development of Chinese enterprises. Through relevant theoretical analysis and development of research hypotheses using the A-shares in Shanghai and Shenzhen listed companies announced in 2007 and 2008, the authors design an empirical model. The study found that in Chinese listed companies, the higher the innovation spirit of senior corporate managers, the better their business performances; the stronger the dynamic and complexity of the operating environment, the more the corporate managers＇ innovation ability will be developed.
文摘We have recently developed a systematic method for the study on the inheritance of resistance to sheath blight. The key of the system is an innovated method of inoculation and investigation along with the employment of the permanent population. This paper reported the procedure of the system and the result of its verification.
文摘In 2008, two governmental committees presented their conclusions on strengthening the role of the private building sector in building control. In 2011, three new studies were commissioned by the government to address perceived problems. One of them was an integral study, executed by ERB （Foundation Expertcentre Regulations in Building）, RIGO （Research Institute for Real Estate） and TNO （Research Institute for Applied Technologies）, to innovate the whole building regulations system. It led to proposals to redefine responsibility and liability for all parties. This study states that by an effort of yearly ￡100 million, unnecessary costs up to ￡l billion can be avoided and a real quality push will take place in the building and real estate markets. The goals to reach are to minimize the administrative burden for the building owner and to enforce the construction industry to build conforming to the regulations. This paper discusses the ERB study and the given proposals. The ERB study demonstrated that a quality push is needed which potential will lead to less costs for building owners. It also shows that proven solutions, part of the regulations, might be of help for all parties involved.
文摘TOWARDS the end of last year, a Chinese magazine released a list of the country’s buzzwords of 2006. It was no surprise that ＂Innovation＂ ranked third. That year witnessed a nationwide campaign of sci-tech innovation that reached unprecedented heat. And this time, the flames spread inland, to places like the frontier province of Yunnan.
基金supported by The Portuguese Foundation for Science and Technology(Grants and NECE-UIDB/04630/2020)which provided financial support for this study.NECE and this work are supported by FCT-Fundacao para a Ciencia e Tecnologia,I.P.by project reference UIDB/04630/2020 and D0I identifier 10.54499/UIDP/04630/2020.
文摘This study analyses the role played by organizational ambidexterity and open innovation in innovation outputs,considering business units with different levels of technological intensity(medium-high and high tech,and medium-low and low tech)for countries with different inno-vation profiles.The countries considered in this paper are i)Estonia and Slovenia as innovation followers;i)Slovakia,Hungary,Spain,Czech Republic,Italy,Portugal,Norway,and Croatia as moderate innovators;and ii)Bulgaria,Lithuania and Romania as modest innovators.In the empirical approach,the research hypotheses arise from the literature review and are tested using secondary data collected from the Community Innovation Survey(CIS)201o.The conceptual model is tested using the logistic regression method,which indicates suitable accuracy and reliability for empirical testing purposes.The evidence reveals that for innovation followers,ambidexterity has a greater influence on the practice of eco-innovation,marketing innovation,and product innovation.For moderate innovators,ambidexterity has a greater influence on the practice of product innovation,process innovation,and eco-innovation.Concerning modest in-novators,ambidexterity has a greater influence on the practice of product innovation,process innovation,and eco-innovation.With regard to open innovation,for innovation followers,this has a negative influence on product innovation in medium-high and high-tech companies.For moderate innovators,open innovation has a greater influence in process,organizational,and eco-innovation.In the case of modest innovators,open innovation is more significant for innovation outputs in product,organizational,and marketing innovation.Size is not always positively related to innovation outputs.
文摘The Porter Hypothesis,proposed by Michael E.Porter,suggests that stringent environmental regulations can enhance corporate innovation and competitiveness,challenging the traditional view that regulations increase business costs.It argues that regulations motivate firms to innovate,leading to improved productivity,cost reductions,and new market opportunities.However,there are proponents and critics in academia regarding the hypothesis.Supporters claim regulations change corporate behavior,reducing agency costs and boosting research and development.Critics argue that if win-win situations exist,businesses would naturally pursue them without regulatory incentives.Key challenges in proving or refuting the hypothesis include its various versions,the difficulty in quantifying innovation and competitiveness,the complex interplay between regulation,innovation,and competitiveness,and the varying impacts across industries and regions.Additionally,the effects may require a long time to manifest,and the hypothesis’s applicability is influenced by evolving environmental policies and market environments.Despite mixed empirical findings,the Porter Hypothesis provides a valuable framework for understanding the relationships among environmental regulation,innovation,and competitiveness,but its validation requires a more comprehensive assessment.
基金University of the Witwatersrand Additional funding is from the DSI-National Research Foundation(NRF)Thuthuka Grant(Grant UID:121973)and DSI-NRF CIMERA.
文摘The pursuit of improved quality of life standards has significantly influenced the contemporary mining model in the 21st century.This era is witnessing an unprecedented transformation driven by pressing concerns related to sustainability,climate change,the just energy transition,dynamic operating environments,and complex social challenges.Such transitions present both opportunities and obstacles.The aim of this study is to provide an extensive literature review on energy transition to identify the challenges and strategies associated with navigating transformations in energy systems.Understanding these transformations is particularly critical in the face of the severe consequences of global warming,where an accelerated energy transition is viewed as a universal remedy.Adopting a socio-technological systems perspective,specifically through the application of Actor Network Theory(ANT),this research provides a theoretical foundation while categorising challenges into five distinct domains and outlining strategies across these different dimensions.These insights are specifically tailored for emerging market countries to effectively navigate energy transition while fostering the development of resilient societies.Furthermore,our findings highlight that energy transition encompasses more than a mere technological shift;it entails fundamental changes in various systemic socio-economic imperatives.Through focusing on the role of social structures in transitions,this study makes a significant and innovative contribution to ANT,which has historically been criticised for its limited acknowledgement of social structures.Consequently,we propose an emerging market energy transition framework,which not only addresses technological aspects,but also integrates social considerations.This framework paves the way for future research and exploration of energy transition dynamics.The outcomes of this study offer valuable insights to policymakers,researchers,and practitioners engaged in the mining industry,enabling them to comprehend the multifaceted challenges involved and providing practical strategies for effective resolution.Through incorporating the social dimension into the analysis,we enhance the understanding of the complex nature of energy system transformations,facilitating a more holistic approach towards achieving sustainable and resilient energy transitions in emerging markets and beyond.
文摘Metabolic dysfunction-associated steatotic liver disease(MASLD),once known as non-alcoholic fatty liver disease(NAFLD),represents a spectrum of liver disorders characterized by lipid accumulation within hepatocytes.The redefinition of NAFLD in 2023 marked a significant reposition in terminology,emphasizing a broader understanding of liver steatosis and its associated risks.MASLD is now recognized as a major risk factor for liver cirrhosis,hepatocellular carcinoma,and systemic complications such as cardiovascular diseases or systemic inflammation.Diagnostic challenges arise,particularly in identifying MASLD in lean individuals,necessitating updated diagnostic protocols and investing in non-invasive diagnostic tools.Therapeutically,there is an urgent need for effective treatments targeting MASLD,with emerging pharmacological options focusing on,among others,carbohydrate and lipid metabolism.Additionally,understanding the roles of bile acid metabolism,the microbiome,and dietary interventions in MASLD pathogenesis and management holds promise for innovative therapeutic approaches.There is a strong need to emphasize the importance of collaborative efforts in understanding,diagnosing,and managing MASLD to improve physicians’approaches and patient outcomes.
文摘The exploration of the way"mass entrepreneurship and innovation"(MEI)education influences students'aspirations to become entrepreneurs has grown into an important area of analysis in studies related to higher education.This research intends to examine the consequences of MEI education on students'tendency towards entrepreneurship,and to put forward methods for augmenting the teaching of innovation and entrepreneurship in private higher educational establishments.To achieve this objective,questionnaires and semi-structured interviews were employed in the study,which involved a total of 197 students and five education experts.The statistical analysis of the questionnaire data revealed that MEI education was positively related to students'entrepreneurial intentions,and that both entrepreneurial experience and family entrepreneurial background played moderating roles in this relationship.The interview findings indicated that private universities could enhance educational reforms by designing talent training programs,developing diversified curricula,and developing more professional entrepreneurial platforms to encourage students'entrepreneurial intentions.This study offers fresh insights for improving and perfecting the mechanism of innovation and entrepreneurship education in private universities.
基金supported by the China National Natural Sciences Fund Project(Nos.71874190 and 72403233)Jiangsu Provincial Department of Science and Technology Program(Innovation Support Program Soft Science Research)(No.BR2023016-4)+2 种基金China Postdoctoral Science Foundation(No.2024M753503)Key Projects Funded by Jiangsu Social Science Fund(No.21GLA003)The Ministry of Education of Humanities and Social Science Project.
文摘The optimization of government subsidies to enhance the efficiency of coal companies’green transformation constitutes a critical component in the pursuit of global sustainability.We investigate the influence mechanism of government subsidies on the green transformation using data from the listed coal companies in China from 2007 to 2022.According to our findings and hypothesis testing,previous government subsidies did not have a significant direct impact on coal companies’green transformation.Nevertheless,government subsidies can help coal companies transition to greener practices by promoting innovative green initiatives.Furthermore,we confirmed an indirect route:that government subsidies enable the adoption of low-carbon initiatives,which in turn could facilitate the transition of coal companies towards green practices.In addition,we discovered that the coal company’s digitization will improve this indirect route.Thus,we propose increasing the effectiveness of government subsidies in facilitating coal companies’transition to green practices by focusing on technological advancements and enhancing company digitalization.
基金support from the Centre of Studies in Geography and Spatial Planning(CEGOT)funded by national funds through the Foundation for Science and Technology(FCT)under the reference UIDB/04084/2020.
文摘The world is facing dramatic challenges related to environmental sustainability at an accelerating pace.In this context,the field of economic geography(EG)has been playing an important role in understanding both the socioeconomic and technological dimensions of these challenges,as it deals with a variety of complementary notions and perspectives.Departing from this lens,our aim is to explore a conceptual framework that can help us to understand environmental changes relating to multi-dimensional territorial development,notably in eco-nomic contexts where inequality is high,and stratification based on hierarchies regulate social and economic life.Based on the territory concept,we propose the original notion of a hierarchical regional innovation system(HRIS)that emphasises the pervasive role of hierarchies(powers)in regional innovation systems and illustrate its value with evidence and case studies from extant literature on sustainability transitions.The HRIS can help us understand and promote development paths considering the contribution of inclusive eco-innovations(another original conceptual amalgam).Through some empirical cases from other studies in low-carbon transitions,we show the application of the HRIS(and inclusive eco-innovation)framework.In conclusion,we provide incen-tives to explore new regional innovation systems,alongside the HRIS,adapted to different regions worldwide and centred on the inclusiveness of people and places.
文摘As the world continues to search for innovative therapeutic solutions,the field of natural medicines has emerged as a vibrant area of research.The potential of natural products to treat a wide range of diseases,coupled with the relatively low sideeffects of such products,has captured the attention of scientists,clinicians,and the general public alike.This Special Issue on Natural Medicine aims to present the latest advancements in this exciting field,highlighting both fundamental research and clinical applications.The collection of articles in this Special Issue covers a broad spectrum of topics,ranging from medicinal chemistry to biological mechanisms,and from the study of single botanic compounds to complex plant formulas.We are particularly pleased to include a comprehensive review by Yi Wang et al.on the bioactivities,mechanisms,production,and potential application of bile acids in preventing and treating infectious diseases.This review not only summarizes the current landscape of bile acids research but also highlights several promising compounds for future investigations,such as the recent interest in ursodeoxycholic acid.In a related topic,Shishan Yu’s team has developed artificial bear bile using synthetic chemistry and enzyme engineering,providing a sustainable substitute for natural bear bile.This innovation meets medical needs while addressing animal welfare issues,representing a notable progression in the field.
文摘Al is revolutionizing the current paradigm of pharmaceutical research,addressing the challenges encountered at all stages of the process.Al driven drug discovery is based on biomedical big data and new algorithms to identify drug targets,screen and optimize active compounds,analyze drug properties,and facilitate drug production and quality control.On this basis,we are organize this special issue entitled“Innovative Pharmaceutical Research Driven by Al”,to collect Research articles,Review papers,and Short communications,facilitating pharmaceutical research.
基金Under the auspices of Natural Science Foundation of China(No.42122006,41971154)。
文摘Firms are embedded in complex networks,where diverse ideas combine and generate new ideas.Shareholders of firms are of-ten seen as critical external resources that have significant influence on firm innovation.The current literature tends to focus on the rela-tionship between firms and their shareholders,while paying less attention to the connections between firms with the same shareholders.This article identifies two types of network spillover effects,intra-city network effect and inter-city network effect,by visualizing the co-ownership networks in China’s electric vehicle(EV)industry.We find that firms with the same shareholders,which are defined as co-owned EV firms,are more innovative than non-co-owned ones.Furthermore,there are two dominant types of firm co-ownership ties formed by corporate and financial institution shareholders.While corporate shareholders help exploiting local tacit knowledge,financial institutions are more active in bridging inter-city connections.The conclusion is confirmed at both firm and city levels.This paper theor-izes the firm co-ownership network as a new form of institutional proximity and tested the result empirically.For policy consideration,we have emphasized the importance of building formal or informal inter-firm network,and the government should further enhance the knowledge flow channel by institutional construction.
文摘Since its inception,Animal Models and Experimental Medicine(AMEM)has received 632 articles in total from 52 countries and regions includ-ing China,Iran,the United States,India,Nigeria,Israel,Germany,Iraq,Italy,Japan,Australia,Bangladesh,Belgium,Brazil,and Canada,among others.AMEM has become an important international exchange plat-form for innovative research achievements in the field of laboratory animal science and basic medicine.
基金supported by the Sichuan province Science&Technology Department Crops Breeding Project(2021YFYZ0002)。
文摘The continued expansion of the world population,increasingly inconsistent climate and shrinking agricultural resources present major challenges to crop breeding.Fortunately,the increasing ability to discover and manipulate genes creates new opportunities to develop more productive and resilient cultivars.Many genes have been described in papers as being beneficial for yield increase.However,few of them have been translated into increased yield on farms.In contrast,commercial breeders are facing gene decidophobia,i.e.,puzzled about which gene to choose for breeding among the many identified,a huge chasm between gene discovery and cultivar innovation.The purpose of this paper is to draw attention to the shortfalls in current gene discovery research and to emphasise the need to align with cultivar innovation.The methodology dictates that genetic studies not only focus on gene discovery but also pay good attention to the genetic backgrounds,experimental validation in relevant environments,appropriate crop management,and data reusability.The close of the gaps should accelerate the application of molecular study in breeding and contribute to future global food security.
基金financed by the National Key Research and Development Program of China,High efficiency space satellite charging system based on microwave wireless energy transfer technology(Grant No.2021YFB3900304)。
文摘This paper presents a systematic methodology for analyzing and optimizing an innovative antenna mount designed for phased array antennas, implemented through a novel 2-PSS&1-RR circular-rail parallel mechanism. Initially, a comparative motion analysis between the 3D model of the mount and its full-scale prototype is conducted to validate effectiveness. Given the inherent complexity, a kinematic mapping model is established between the mount and the crank-slider linkage, providing a guiding framework for subsequent analysis and optimization. Guided by this model, feasible inverse and forward solutions are derived, enabling precise identification of stiffness singularities. The concept of singularity distance is thus introduced to reflect the structural stiffness of the mount. Subsequently, also guided by the mapping model, a heuristic algorithm incorporating two backtracking procedures is developed to reduce the mount's mass. Additionally, a parametric finite-element model is employed to explore the relation between singularity distance and structural stiffness. The results indicate a significant reduction(about 16%) in the antenna mount's mass through the developed algorithm, while highlighting the singularity distance as an effective stiffness indicator for this type of antenna mount.
