The aim of this study was to evaluate the factors influencing the inactivation effect of intense pulsed light(IPL)on Aeromonas salmonicida grown on chicken meat and skin,and to further develop prediction models of ina...The aim of this study was to evaluate the factors influencing the inactivation effect of intense pulsed light(IPL)on Aeromonas salmonicida grown on chicken meat and skin,and to further develop prediction models of inactivation.In this work,chicken meat and skin inoculated with meat-borne A.salmonicida isolates were subjected to IPL treatments under different conditions.The results showed that IPL had obvious bactericidal effect in the chicken skin and thickness groups when the treatment voltage and time were 7 V combined with 5 s.In addition,the lethality curves of A.salmonicida were fitted under IPL conditions of 3.5-7.5 V.The comparison of statistical parameters revealed that the Weibull model could best fit the mortality curves and could accurately predict the mortality dynamic of A.salmonicida grown on chicken skin.And further a secondary model between the scale factor b and the treatment voltage in Weibull model was established using linear equations,which determined that the secondary model could accurately predict the inactivation of A.salmonicida.This study provides a theoretical basis for future prediction models of Aeromonas,and also provides new ideas for sterilization approaches of meat-borne Aeromonas.展开更多
AIM:To investigate the efficacy and mechanisms of indirect intense pulsed light(IPL)irradiation on meibomian gland dysfunction(MGD).METHODS:A total of 60 MGD patients was included in this prospective randomized contro...AIM:To investigate the efficacy and mechanisms of indirect intense pulsed light(IPL)irradiation on meibomian gland dysfunction(MGD).METHODS:A total of 60 MGD patients was included in this prospective randomized controlled trial.Patients were randomly assigned 1:1 into two groups(3-mm group and 10-mm group)in which IPL was applied at distances from the lower eyelid margin of 3 and 10 mm,respectively.Both groups received three times treatment with 3-week interval.Meibomian gland yield secretion score(MGYSS),standard patient evaluation of eye dryness(SPEED)questionnaire,tear break-up time(TBUT),corneal fluorescein staining(CFS),and in vivo confocal microscopy were performed at baseline and after every treatment.RESULTS:After three IPL treatments,both groups had significant improvement in MGYSS(both P<0.05).The noninferiority test showed that improvement in 10-mm group was not inferior to that in 3-mm group(P<0.001).In both groups,temporal regions of both upper and lower eyelids showed significant improvement in MGYSS.Scores of SPEED questionnaire in both groups declined significantly(both P<0.001)and changes of SPEED had no difference between two groups(P=0.57).Density of central corneal subepithelial nerves and TBUTs showed no statistically significant changes.The 3-mm group had improvement on corneal fluorescein staining(P=0.048)and meibomian gland morphology(acini wall thickness P=0.003,hyperreflective points P=0.024)while the 10-mm group had not.CONCLUSION:The efficacy of IPL indirect irradiation in improving meibomian gland secretion and alleviating dry eye symptoms remains unchanged with increase in treatment distance.IPL may primarily act on the functional improvement of the meibomian glands and corneal nerves.展开更多
Objective To evaluate the effect of intense pulsed light(IPL)in the treatment of chronic hordeolum.Methods Patients with chronic hordeolum who underwent IPL treatment were enrolled in this study.According to the sever...Objective To evaluate the effect of intense pulsed light(IPL)in the treatment of chronic hordeolum.Methods Patients with chronic hordeolum who underwent IPL treatment were enrolled in this study.According to the severity of hordeolum,the patients were treated with IPL 3 to 5 times.Patients’satisfaction and visual analog scale scores for ocular discomfort symptoms before and after treatment were collected.The number,congestion,long diameter,short diameter and area of nodules were also recorded and measured.Finally,eyelid margin signs,meibum quality,meibomian gland expressibility,meibomian gland dropout,tear meniscus height,and corneal fluorescein staining were scored.Results 20 patients were enrolled in this study.The eyelid margins were congestive and swollen,with blunt rounding or irregularity.The meibum was cloudy or toothpaste-like.The meibomian gland expressibility,meibomian gland dropout and tear meniscus height were reduced.The cornea showed scattered fluorescein staining.After treatment,score of visual analog scale,congestion and size of nodules were significantly reduced.Eyelid margin signs,meibum quality,meibomian gland expressibility,tear meniscus height and corneal fluorescein staining scores were improved.Meibomian gland dropout had no significant change.No side effects occurred during treatment.Conclusions IPL is beneficial for the treatment of chronic hordeolum.展开更多
Background:Ocular surface disease in glaucoma patients is a significant ocular co-morbidity that can affect 40%to 59%of these patients worldwide.The current study was aimed at evaluating the potential clinical benefit...Background:Ocular surface disease in glaucoma patients is a significant ocular co-morbidity that can affect 40%to 59%of these patients worldwide.The current study was aimed at evaluating the potential clinical benefit of an intense pulsed light(IPL)-based treatment in glaucomatous patients with ocular surface disease due to prolonged hypotensive eyedrop treatments.To our knowledge,this is the first series analyzing the therapeutic effect of this treatment option in this type of patients.Methods:This non-comparative prospective case series study enrolled a total of 30 glaucoma patients ranging in age from 57 to 94 years old and treated with hypotensive eyedrops for years with dry eye symptomatology.All patients received four sessions of IPL treatment using the Optima IPL system(Lumenis,Yokneam,Israel)adjusted to the official optimized Lumenis setting.Changes in symptomatology,corneal staining,conjunctival hyperemia,non-invasive break-up time(NIBUT),tear osmolarity,tear meniscus height(TMH),meiboscore and meibomian gland expressibility was analyzed after treatment.Results:Statistically significant reductions were observed after IPL treatment in the symptomatology scores measured with different questionnaires[ocular surface disease index(OSDI),standard patient evaluation of eye dryness(SPEED)and symptom assessment questionnaire in dry eye(SANDE)]as well as with the visual analogue scale(P<0.001).Mean change in OSDI was−15.0±11.3.A significant reduction was found after treatment in the corneal staining score(P<0.001).A significant reduction was found in tear film meniscus height(P=0.012),as well as in tear film osmolarity(P=0.001).A significant reduction was also found in meibomian gland expressibility(P=0.003),changing the percentage of grade 3 eyes from 44.4%before IPL to 17.2%after treatment.Conclusions:IPL therapy combined with meibomian gland expression(MGX)seems to be an effective option to improve symptomatology in glaucomatous patients with ocular surface disease due to prolonged hypotensive eyedrop treatments,with an additional improvement in clinical signs,such as tear osmolarity and corneal staining.展开更多
The development of simple and high-throughput approaches to yield solid-state nanopores on large surface membranes may facilitate the prevalence of nanopore analysis technology and in-vitro diagnosis using portable de...The development of simple and high-throughput approaches to yield solid-state nanopores on large surface membranes may facilitate the prevalence of nanopore analysis technology and in-vitro diagnosis using portable devices.However,solidstate nanopores are typically realized by complex and highend nanofabrication equipments.Here,we present a method to achieve nanopores on polymer membranes using,silver nanoparticles(AgNPs)as templates and intense pulsed light(IPL)as a heating source.The density and size of nanopores are controllable by adjusting the spin coating rate,the concentration of nanoparticle suspension,and the size of nanoparticles(NPs).The temperature of the AgNPs can rapidly reach 1132 K under instant heating of photothermal effect through light irradiation in 2 ms,resulting in localized melting and decomposition of an underneath polycarbonate(PC)membrane to yield nanopores with sizes ranging from 10 to 270 nm.After removing the nanoparticle residues,the flexible membrane with nanopores can be integrated into a flow cell to achieve a nanopore sensor that has been used to measure the translocation behaviors of bovine serum albumin(BSA).The results have demonstrated the capability of the sensor in protein denaturation identification.This low-cost and highthroughput technique to fabricate solid-state nanopores on flexible polymeric membranes may facilitate the development of more nanopore-based flexible sensors that can be integrated with other flexible components for wearable diagnosis.展开更多
Traumatic scarring is one of the most common complications after soft tissue injury caused by burns and trauma,which affects tens of millions of people worldwide every year.Traumatic scars diminish the quality of life...Traumatic scarring is one of the most common complications after soft tissue injury caused by burns and trauma,which affects tens of millions of people worldwide every year.Traumatic scars diminish the quality of life due to disfigurement,symptoms of pain and itch,and restricted motion.The pathogenesis and pathophysiology of traumatic scar remain elusive.The management for traumatic scars is comprised of surgical and non-surgical interventions such as pressure therapy,silicone,corticosteroid,and radiotherapy,which are chosen by clinicians based on the physical examinations of scars.Recently,great progress in treating traumatic scars has been achieved by the development of novel technologies including laser,intense pulsed light(IPL),radiofrequency,and ultrasound.The aim of this review article was to summarize the advances of these technologies for traumatic scars intervention.展开更多
Objective: To observe the clinical therapeutic effect of acupuncture plus intensive pulse light irradiation on chloasma. Methods: Ninety-six cases of chloasma were randomly divided into two groups, the control group o...Objective: To observe the clinical therapeutic effect of acupuncture plus intensive pulse light irradiation on chloasma. Methods: Ninety-six cases of chloasma were randomly divided into two groups, the control group of 46 cases treated by simple acupuncture and the treatment group of 50 cases treated by acupuncture and intensive pulse light irradiation. Results: The total effective rate was 89.1% and 98.0% in the control group and treatment group respectively, with a significant difference between the two groups (P<0.05). Conclusion: For chloasma, the effect of treatment with acupuncture plus intensive pulse light irradiation is superior to that with simple acupuncture.展开更多
Although perovskite solar cells(PSCs)have achieved a high power conversion efficiency(PCE)within a short period of development,the high-temperature sintering of the constituent electron-selective layers(ESLs)impedes t...Although perovskite solar cells(PSCs)have achieved a high power conversion efficiency(PCE)within a short period of development,the high-temperature sintering of the constituent electron-selective layers(ESLs)impedes the commercialization.In this report,we demonstrate the effectiveness of an intensepulsed-light(IPL)treatment for the rapid and damage-free sintering of amorphous-SnO_(2)ESLs for use in PSCs.The IPL treatment of amorphous-SnO_(2)substantially reduced the amount of surface hydroxyl groups,modified the surface energy,and enabled the growth of a low-stress perovskite layer with large grain sizes,all of which enhanced the photovoltaic properties and led to the proper alignment of band structures for efficient PSCs.Through comprehensive optimization of the IPL conditions,a PCE of 17.68%was achieved from the MAPb I3 planar PSC based on an amorphous-SnO_(2)IPL treated for a few tens of seconds,which was significantly increased compared with a PCE(7.06%)of nontreated SnO_(2)based counterpart.In addition,the PCE of the IPL-treated SnO_(2)based PSC is comparable to the best PCE(18.16%)of PSCs fabricated with SnO_(2)ESL annealed for three hours at 185℃.Because of its ultrafast sintering time and tendency to not damage SnO_(2)ESLs,the new IPL process is expected to open new opportunities for the commercialization of PSCs.展开更多
Objective We investigated the efficacy and safety of 1064 nm Nd： YAG laser, intense pulsed light （IPL）, and lauromacrogol injection in the treatment of hemangioma, in order to evaluate the value of color Doppler u...Objective We investigated the efficacy and safety of 1064 nm Nd： YAG laser, intense pulsed light （IPL）, and lauromacrogol injection in the treatment of hemangioma, in order to evaluate the value of color Doppler ultrasound guidance in choosing the optimal treatment modality. Methods Infantile patients who were clinical diagnosed as hemangiomas were randomly divided into group A, who had color Doppler ultrasound examinations before the treatment, and group B who had the treatment without ultrasound evaluation. Patients in the group A were assigned into subgroups according to the depth of lesion by sonography： group A-1 for those who had a lesion depth 〈1.2 mm, and took intense pulsed light therapy; group A-2 for those who had a lesion depth ≥1.2mm and 〈 3 mm, and took long pulse 1064 nm Nd：YAG laser therapy; group A-3 for those who had a lesion depth ≥3mm and 〈5 mm, and were treated by IPL combined with long pulse 1064 nm Nd：YAG laser treatment; Group A-4 for those who had a lesion depth ≥5 mm, and took lauromacrogol injection therapy. Patients in the group B took long pulse 1064 nm Nd：YAG laser treatment without preoperative ultrasound evaluation. The efficacy and adverse reactions of the treatments between the groups were evaluated and compared statistically. Results Totally 113 patients with 128 skin lesions were enrolled in this study, 85 in the group A （mean age 6.8±7.9 months） and 28 in the group B （mean age 6.9±9.9 months）. The mean depth of hemangioma was 3.3±1.1 mm in the group A, ranging from 0.5-7.8 mm, with 0.8±0.4 mm, 2.2±0.4 mm, 4.2±0.6 mm and 6.2±0.7 mm in group A1, A2, A3 and A4, respectively. The cure rates and effective rates in the group A were significantly higher than those in the group B （cure rates： 64.5% vs 56.3%, U=3.378, P=0.045; effective rates： 89.5% vs 78.1%, U=4.163, P=0.041）. The adverse effect rates of the group A （vesicle 20.0%, pigmentation 46.9%, scarring 17.7%） were lower than those of the group B （vesicle 21.9%, pigmentation 60.4%, scarring 25.0%）. Incidences of pigmentation and scarring were statistically significantly different （U=3.884, P=0.034, and U=4.016, P=0.032 respectively） between the two groups. Conclusion With the guidance of color Doppler ultrasound, the efficacy and safety of long pulse 1064 nmNd：YAG laser, intense pulsed light, and lauromacrogol injection in the treatment of infantile hemangioma have better outcomes compared to laser treatment alone without preoperative ultrasound examination.展开更多
AIM:To establish a new inflammatory animal model of meibomian gland dysfunction(MGD)in C57BL/6 mice.METHODS:C57BL/6 mice were randomly divided into complete Freund’s adjuvant(CFA)group(14 animals,14 eyes),naphthazoli...AIM:To establish a new inflammatory animal model of meibomian gland dysfunction(MGD)in C57BL/6 mice.METHODS:C57BL/6 mice were randomly divided into complete Freund’s adjuvant(CFA)group(14 animals,14 eyes),naphthazolin hydrochloride(NH)group(14 animals,14 eyes)and control group(14 animals,14 eyes).In CFA group,CFA was used in eyelid conjunctiva injection;in NH group,NH eye drops were used twice a day;control group was injected with equal dose of saline at the same time point and same site with animals in CFA group.The meibomian gland orifices score(MGOS)was evaluated on a scale of 0 to 3 in the middle five meibomian gland orifices of the upper and lower eyelid using slit lamp.After the successful induction of each animal model,intense pulsed light(IPL)was introduced on each mouse in CFA and NH group.Oil red O(ORO),hematoxylin and eosin(H&E)staining were performed before and after successful induction of CFA,NH and control group.RESULTS:At 12wk after CFA injection,inflammatory cell infiltration and fiber necrosis was observed,with acinar density and duct dilatation significantly lower compared with control group.In NH group,the meibomian gland acini were relatively smaller and deformed compared with control group,the number of meibomian gland acini was also slightly lower.No inflammatory cell or fiber necrosis was observed in NH group.After three times of IPL treatment(5/10 mice in each group,and the other 5 mice served as non-IPL control),MGOS was significantly lower in IPL-treated mice in NH group(P<0.01).After three times of IPL treatment,the MGOS of NH group was significantly lower than that in the CFA group(P<0.01).CONCLUSION:We develop a novel animal model that studies the role of inflammation in the development of MGD and IPL treatment.This model indicates that persistent inflammatory state may be the cause of MGD and weaken the therapeutic effect of IPL.展开更多
<strong>Introduction:</strong> Intense Pulsed Light (IPL) technology is well accepted in the medical aesthetic field for the treatment of various skin lesions, including pigmented and vascular lesions. The...<strong>Introduction:</strong> Intense Pulsed Light (IPL) technology is well accepted in the medical aesthetic field for the treatment of various skin lesions, including pigmented and vascular lesions. The light penetrates into the skin and is selectively absorbed by lesion chromophore. Absorbed energy is converted into heat, coagulating the lesion, which naturally fades following the treatment. The current article presents a retrospective efficacy evaluation of an IPL device with high peak power. <strong>Methods:</strong> Representative treatment results were collected from several clinics based on photographs taken at baseline and after treatments. Photos were evaluated and analyzed for aesthetic improvement of the various skin conditions in different facial and body areas. <strong>Results:</strong> Analysis included cases of pigmented and vascular lesions, textural lesions, and more specific conditions such as melasma and rosacea. The two evaluators’ scoring demonstrated improvement in all cases according to the Global Aesthetic Improvement Scale (GAIS) scale. <strong>Conclusion:</strong> The vast experience gathered from the market in treating various skin lesions supports the safety and efficacy of the investigated IPL device. The device’s particular specifications contribute to the successful results and ease of treatment for the practitioner and the patient.展开更多
A high peak power IPL system (Lumecca) was tested to determine the correlation between a high peak power and the successful treatment of pigmented and vascular lesions. Short pulse duration in the millisecond range an...A high peak power IPL system (Lumecca) was tested to determine the correlation between a high peak power and the successful treatment of pigmented and vascular lesions. Short pulse duration in the millisecond range and high peak power of 3.3 kW/cm<sup>2</sup> enabled selective and effective destruction, not only of pigment, but also of vessels in a comparable manner to a pulsed dye laser. Only one treatment session at a low fluence (8 - 16 J/cm<sup>2</sup>) was sufficient to achieve the desired results.展开更多
The meibomian gland is a unique sebaceous gland located in the eyelid.Its main function is to secrete lipids and form the lipid layer of the tear film to delay the evaporation of waterborne tears,increase the surface ...The meibomian gland is a unique sebaceous gland located in the eyelid.Its main function is to secrete lipids and form the lipid layer of the tear film to delay the evaporation of waterborne tears,increase the surface tension of the tear film,and to lubricate the contact area of the eyelid and eyeball.Abnormal secretion of the meibomian gland is known as meibomian gland dysfunction(MGD),which has become the most important cause of evaporative dry eye disease(DED).The clinical pathophysiological process and underlying molecular mechanisms of MGD are not clear.As serious side effects may occur with the long-term use of hormonotherapy and non-steroidal anti-inflammatory drugs(NSAIDs)for the treatment of MGD,meibomian gland physiotherapy is considered the most effective and safest therapy for MGD.This review summarizes the physical therapy modalities of western medicine(WM)and traditiond Chinese medicine(TCM)for the treatment of MGD to provide optimal treatments for these patients and to further lay a foundation for mechanistic studies of MGD.展开更多
The study of photonic sintering has gained interest based on the advantages of fast processing at room temperature.However,printed electronics made from photonic sintering with an intensive pulsed light(IPL)energy sou...The study of photonic sintering has gained interest based on the advantages of fast processing at room temperature.However,printed electronics made from photonic sintering with an intensive pulsed light(IPL)energy source exhibit more mechanical instability than those made from conventional thermal sintering processes.To solve the mechanical instability problems,we fabricated Ag flake hybrid pastes with a variety of concentrations of Ag flake(0,25,50,75,and 100 wt.%).All of the screen-printed hybrid Ag circuits were fabricated on polyimide substrates and were sintered at 3.5 MW.Surface porosity was analyzed using the Brunauer-Emmett-Teller method.An IPC(Packaging Electronic Circuits)sliding test was performed to analyze the flexibility of the screen-printed Ag flake hybrid circuits.The adhesion strength of the hybrid circuits was evaluated with a roll-type 90°peel test.The hybrid Ag printed circuit showed improvements in both the flexibility and adhesion strength with the addition of Ag flake.展开更多
基金supported by projects funded by grants from the Natural Science Foundation of Jiangsu Province in China(BK20221515)the National Natural Science Foundation of China(32172266)the Changzhou Science and Technology Support Program(CE20222002)。
文摘The aim of this study was to evaluate the factors influencing the inactivation effect of intense pulsed light(IPL)on Aeromonas salmonicida grown on chicken meat and skin,and to further develop prediction models of inactivation.In this work,chicken meat and skin inoculated with meat-borne A.salmonicida isolates were subjected to IPL treatments under different conditions.The results showed that IPL had obvious bactericidal effect in the chicken skin and thickness groups when the treatment voltage and time were 7 V combined with 5 s.In addition,the lethality curves of A.salmonicida were fitted under IPL conditions of 3.5-7.5 V.The comparison of statistical parameters revealed that the Weibull model could best fit the mortality curves and could accurately predict the mortality dynamic of A.salmonicida grown on chicken skin.And further a secondary model between the scale factor b and the treatment voltage in Weibull model was established using linear equations,which determined that the secondary model could accurately predict the inactivation of A.salmonicida.This study provides a theoretical basis for future prediction models of Aeromonas,and also provides new ideas for sterilization approaches of meat-borne Aeromonas.
基金Supported by the National Natural Science Foundation of China(No.81870629).
文摘AIM:To investigate the efficacy and mechanisms of indirect intense pulsed light(IPL)irradiation on meibomian gland dysfunction(MGD).METHODS:A total of 60 MGD patients was included in this prospective randomized controlled trial.Patients were randomly assigned 1:1 into two groups(3-mm group and 10-mm group)in which IPL was applied at distances from the lower eyelid margin of 3 and 10 mm,respectively.Both groups received three times treatment with 3-week interval.Meibomian gland yield secretion score(MGYSS),standard patient evaluation of eye dryness(SPEED)questionnaire,tear break-up time(TBUT),corneal fluorescein staining(CFS),and in vivo confocal microscopy were performed at baseline and after every treatment.RESULTS:After three IPL treatments,both groups had significant improvement in MGYSS(both P<0.05).The noninferiority test showed that improvement in 10-mm group was not inferior to that in 3-mm group(P<0.001).In both groups,temporal regions of both upper and lower eyelids showed significant improvement in MGYSS.Scores of SPEED questionnaire in both groups declined significantly(both P<0.001)and changes of SPEED had no difference between two groups(P=0.57).Density of central corneal subepithelial nerves and TBUTs showed no statistically significant changes.The 3-mm group had improvement on corneal fluorescein staining(P=0.048)and meibomian gland morphology(acini wall thickness P=0.003,hyperreflective points P=0.024)while the 10-mm group had not.CONCLUSION:The efficacy of IPL indirect irradiation in improving meibomian gland secretion and alleviating dry eye symptoms remains unchanged with increase in treatment distance.IPL may primarily act on the functional improvement of the meibomian glands and corneal nerves.
文摘Objective To evaluate the effect of intense pulsed light(IPL)in the treatment of chronic hordeolum.Methods Patients with chronic hordeolum who underwent IPL treatment were enrolled in this study.According to the severity of hordeolum,the patients were treated with IPL 3 to 5 times.Patients’satisfaction and visual analog scale scores for ocular discomfort symptoms before and after treatment were collected.The number,congestion,long diameter,short diameter and area of nodules were also recorded and measured.Finally,eyelid margin signs,meibum quality,meibomian gland expressibility,meibomian gland dropout,tear meniscus height,and corneal fluorescein staining were scored.Results 20 patients were enrolled in this study.The eyelid margins were congestive and swollen,with blunt rounding or irregularity.The meibum was cloudy or toothpaste-like.The meibomian gland expressibility,meibomian gland dropout and tear meniscus height were reduced.The cornea showed scattered fluorescein staining.After treatment,score of visual analog scale,congestion and size of nodules were significantly reduced.Eyelid margin signs,meibum quality,meibomian gland expressibility,tear meniscus height and corneal fluorescein staining scores were improved.Meibomian gland dropout had no significant change.No side effects occurred during treatment.Conclusions IPL is beneficial for the treatment of chronic hordeolum.
文摘Background:Ocular surface disease in glaucoma patients is a significant ocular co-morbidity that can affect 40%to 59%of these patients worldwide.The current study was aimed at evaluating the potential clinical benefit of an intense pulsed light(IPL)-based treatment in glaucomatous patients with ocular surface disease due to prolonged hypotensive eyedrop treatments.To our knowledge,this is the first series analyzing the therapeutic effect of this treatment option in this type of patients.Methods:This non-comparative prospective case series study enrolled a total of 30 glaucoma patients ranging in age from 57 to 94 years old and treated with hypotensive eyedrops for years with dry eye symptomatology.All patients received four sessions of IPL treatment using the Optima IPL system(Lumenis,Yokneam,Israel)adjusted to the official optimized Lumenis setting.Changes in symptomatology,corneal staining,conjunctival hyperemia,non-invasive break-up time(NIBUT),tear osmolarity,tear meniscus height(TMH),meiboscore and meibomian gland expressibility was analyzed after treatment.Results:Statistically significant reductions were observed after IPL treatment in the symptomatology scores measured with different questionnaires[ocular surface disease index(OSDI),standard patient evaluation of eye dryness(SPEED)and symptom assessment questionnaire in dry eye(SANDE)]as well as with the visual analogue scale(P<0.001).Mean change in OSDI was−15.0±11.3.A significant reduction was found after treatment in the corneal staining score(P<0.001).A significant reduction was found in tear film meniscus height(P=0.012),as well as in tear film osmolarity(P=0.001).A significant reduction was also found in meibomian gland expressibility(P=0.003),changing the percentage of grade 3 eyes from 44.4%before IPL to 17.2%after treatment.Conclusions:IPL therapy combined with meibomian gland expression(MGX)seems to be an effective option to improve symptomatology in glaucomatous patients with ocular surface disease due to prolonged hypotensive eyedrop treatments,with an additional improvement in clinical signs,such as tear osmolarity and corneal staining.
基金supported by National Natural Science Foundation of China under Grant No.52121002the Key Research and Development Program of Zhejiang Province under Grant No.2021C05005.
文摘The development of simple and high-throughput approaches to yield solid-state nanopores on large surface membranes may facilitate the prevalence of nanopore analysis technology and in-vitro diagnosis using portable devices.However,solidstate nanopores are typically realized by complex and highend nanofabrication equipments.Here,we present a method to achieve nanopores on polymer membranes using,silver nanoparticles(AgNPs)as templates and intense pulsed light(IPL)as a heating source.The density and size of nanopores are controllable by adjusting the spin coating rate,the concentration of nanoparticle suspension,and the size of nanoparticles(NPs).The temperature of the AgNPs can rapidly reach 1132 K under instant heating of photothermal effect through light irradiation in 2 ms,resulting in localized melting and decomposition of an underneath polycarbonate(PC)membrane to yield nanopores with sizes ranging from 10 to 270 nm.After removing the nanoparticle residues,the flexible membrane with nanopores can be integrated into a flow cell to achieve a nanopore sensor that has been used to measure the translocation behaviors of bovine serum albumin(BSA).The results have demonstrated the capability of the sensor in protein denaturation identification.This low-cost and highthroughput technique to fabricate solid-state nanopores on flexible polymeric membranes may facilitate the development of more nanopore-based flexible sensors that can be integrated with other flexible components for wearable diagnosis.
基金supported by the National Natural Science Foundation of China(No.81772118,81501656).
文摘Traumatic scarring is one of the most common complications after soft tissue injury caused by burns and trauma,which affects tens of millions of people worldwide every year.Traumatic scars diminish the quality of life due to disfigurement,symptoms of pain and itch,and restricted motion.The pathogenesis and pathophysiology of traumatic scar remain elusive.The management for traumatic scars is comprised of surgical and non-surgical interventions such as pressure therapy,silicone,corticosteroid,and radiotherapy,which are chosen by clinicians based on the physical examinations of scars.Recently,great progress in treating traumatic scars has been achieved by the development of novel technologies including laser,intense pulsed light(IPL),radiofrequency,and ultrasound.The aim of this review article was to summarize the advances of these technologies for traumatic scars intervention.
文摘Objective: To observe the clinical therapeutic effect of acupuncture plus intensive pulse light irradiation on chloasma. Methods: Ninety-six cases of chloasma were randomly divided into two groups, the control group of 46 cases treated by simple acupuncture and the treatment group of 50 cases treated by acupuncture and intensive pulse light irradiation. Results: The total effective rate was 89.1% and 98.0% in the control group and treatment group respectively, with a significant difference between the two groups (P<0.05). Conclusion: For chloasma, the effect of treatment with acupuncture plus intensive pulse light irradiation is superior to that with simple acupuncture.
基金supported by Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Science and ICT(2020R1F1A1068664)supported by the Defense Challengeable Future Technology Program of the Agency for Defense Development,Republic of Korea。
文摘Although perovskite solar cells(PSCs)have achieved a high power conversion efficiency(PCE)within a short period of development,the high-temperature sintering of the constituent electron-selective layers(ESLs)impedes the commercialization.In this report,we demonstrate the effectiveness of an intensepulsed-light(IPL)treatment for the rapid and damage-free sintering of amorphous-SnO_(2)ESLs for use in PSCs.The IPL treatment of amorphous-SnO_(2)substantially reduced the amount of surface hydroxyl groups,modified the surface energy,and enabled the growth of a low-stress perovskite layer with large grain sizes,all of which enhanced the photovoltaic properties and led to the proper alignment of band structures for efficient PSCs.Through comprehensive optimization of the IPL conditions,a PCE of 17.68%was achieved from the MAPb I3 planar PSC based on an amorphous-SnO_(2)IPL treated for a few tens of seconds,which was significantly increased compared with a PCE(7.06%)of nontreated SnO_(2)based counterpart.In addition,the PCE of the IPL-treated SnO_(2)based PSC is comparable to the best PCE(18.16%)of PSCs fabricated with SnO_(2)ESL annealed for three hours at 185℃.Because of its ultrafast sintering time and tendency to not damage SnO_(2)ESLs,the new IPL process is expected to open new opportunities for the commercialization of PSCs.
基金Supported by grants of the National Natural Science of China(No.81000700No.81573072)
文摘Objective We investigated the efficacy and safety of 1064 nm Nd： YAG laser, intense pulsed light （IPL）, and lauromacrogol injection in the treatment of hemangioma, in order to evaluate the value of color Doppler ultrasound guidance in choosing the optimal treatment modality. Methods Infantile patients who were clinical diagnosed as hemangiomas were randomly divided into group A, who had color Doppler ultrasound examinations before the treatment, and group B who had the treatment without ultrasound evaluation. Patients in the group A were assigned into subgroups according to the depth of lesion by sonography： group A-1 for those who had a lesion depth 〈1.2 mm, and took intense pulsed light therapy; group A-2 for those who had a lesion depth ≥1.2mm and 〈 3 mm, and took long pulse 1064 nm Nd：YAG laser therapy; group A-3 for those who had a lesion depth ≥3mm and 〈5 mm, and were treated by IPL combined with long pulse 1064 nm Nd：YAG laser treatment; Group A-4 for those who had a lesion depth ≥5 mm, and took lauromacrogol injection therapy. Patients in the group B took long pulse 1064 nm Nd：YAG laser treatment without preoperative ultrasound evaluation. The efficacy and adverse reactions of the treatments between the groups were evaluated and compared statistically. Results Totally 113 patients with 128 skin lesions were enrolled in this study, 85 in the group A （mean age 6.8±7.9 months） and 28 in the group B （mean age 6.9±9.9 months）. The mean depth of hemangioma was 3.3±1.1 mm in the group A, ranging from 0.5-7.8 mm, with 0.8±0.4 mm, 2.2±0.4 mm, 4.2±0.6 mm and 6.2±0.7 mm in group A1, A2, A3 and A4, respectively. The cure rates and effective rates in the group A were significantly higher than those in the group B （cure rates： 64.5% vs 56.3%, U=3.378, P=0.045; effective rates： 89.5% vs 78.1%, U=4.163, P=0.041）. The adverse effect rates of the group A （vesicle 20.0%, pigmentation 46.9%, scarring 17.7%） were lower than those of the group B （vesicle 21.9%, pigmentation 60.4%, scarring 25.0%）. Incidences of pigmentation and scarring were statistically significantly different （U=3.884, P=0.034, and U=4.016, P=0.032 respectively） between the two groups. Conclusion With the guidance of color Doppler ultrasound, the efficacy and safety of long pulse 1064 nmNd：YAG laser, intense pulsed light, and lauromacrogol injection in the treatment of infantile hemangioma have better outcomes compared to laser treatment alone without preoperative ultrasound examination.
基金Supported by National Natural Science Foundation of China(No.81700797)Science and Technology Commission of Shanghai Municipality(No.17411961800).
文摘AIM:To establish a new inflammatory animal model of meibomian gland dysfunction(MGD)in C57BL/6 mice.METHODS:C57BL/6 mice were randomly divided into complete Freund’s adjuvant(CFA)group(14 animals,14 eyes),naphthazolin hydrochloride(NH)group(14 animals,14 eyes)and control group(14 animals,14 eyes).In CFA group,CFA was used in eyelid conjunctiva injection;in NH group,NH eye drops were used twice a day;control group was injected with equal dose of saline at the same time point and same site with animals in CFA group.The meibomian gland orifices score(MGOS)was evaluated on a scale of 0 to 3 in the middle five meibomian gland orifices of the upper and lower eyelid using slit lamp.After the successful induction of each animal model,intense pulsed light(IPL)was introduced on each mouse in CFA and NH group.Oil red O(ORO),hematoxylin and eosin(H&E)staining were performed before and after successful induction of CFA,NH and control group.RESULTS:At 12wk after CFA injection,inflammatory cell infiltration and fiber necrosis was observed,with acinar density and duct dilatation significantly lower compared with control group.In NH group,the meibomian gland acini were relatively smaller and deformed compared with control group,the number of meibomian gland acini was also slightly lower.No inflammatory cell or fiber necrosis was observed in NH group.After three times of IPL treatment(5/10 mice in each group,and the other 5 mice served as non-IPL control),MGOS was significantly lower in IPL-treated mice in NH group(P<0.01).After three times of IPL treatment,the MGOS of NH group was significantly lower than that in the CFA group(P<0.01).CONCLUSION:We develop a novel animal model that studies the role of inflammation in the development of MGD and IPL treatment.This model indicates that persistent inflammatory state may be the cause of MGD and weaken the therapeutic effect of IPL.
文摘<strong>Introduction:</strong> Intense Pulsed Light (IPL) technology is well accepted in the medical aesthetic field for the treatment of various skin lesions, including pigmented and vascular lesions. The light penetrates into the skin and is selectively absorbed by lesion chromophore. Absorbed energy is converted into heat, coagulating the lesion, which naturally fades following the treatment. The current article presents a retrospective efficacy evaluation of an IPL device with high peak power. <strong>Methods:</strong> Representative treatment results were collected from several clinics based on photographs taken at baseline and after treatments. Photos were evaluated and analyzed for aesthetic improvement of the various skin conditions in different facial and body areas. <strong>Results:</strong> Analysis included cases of pigmented and vascular lesions, textural lesions, and more specific conditions such as melasma and rosacea. The two evaluators’ scoring demonstrated improvement in all cases according to the Global Aesthetic Improvement Scale (GAIS) scale. <strong>Conclusion:</strong> The vast experience gathered from the market in treating various skin lesions supports the safety and efficacy of the investigated IPL device. The device’s particular specifications contribute to the successful results and ease of treatment for the practitioner and the patient.
文摘A high peak power IPL system (Lumecca) was tested to determine the correlation between a high peak power and the successful treatment of pigmented and vascular lesions. Short pulse duration in the millisecond range and high peak power of 3.3 kW/cm<sup>2</sup> enabled selective and effective destruction, not only of pigment, but also of vessels in a comparable manner to a pulsed dye laser. Only one treatment session at a low fluence (8 - 16 J/cm<sup>2</sup>) was sufficient to achieve the desired results.
基金We thank for the funding support from the Research and Innovation Project of Graduate Students in Hunan Province(No.CX20190538)the First-class Open Fund for Integrated Chinese and Western Medicine(No.2018ZXYJH05)+1 种基金the Traditional Chinese Medicine First-Class Discipline Open Fund(No.2018ZYX57)the Construction Project of Hunan Engineering Technology Research Center for the Prevention and Treatment of Otorhinolaryngologic Diseases and Protection of Visual Function with Chinese Medicine(No.2018YGC02).
文摘The meibomian gland is a unique sebaceous gland located in the eyelid.Its main function is to secrete lipids and form the lipid layer of the tear film to delay the evaporation of waterborne tears,increase the surface tension of the tear film,and to lubricate the contact area of the eyelid and eyeball.Abnormal secretion of the meibomian gland is known as meibomian gland dysfunction(MGD),which has become the most important cause of evaporative dry eye disease(DED).The clinical pathophysiological process and underlying molecular mechanisms of MGD are not clear.As serious side effects may occur with the long-term use of hormonotherapy and non-steroidal anti-inflammatory drugs(NSAIDs)for the treatment of MGD,meibomian gland physiotherapy is considered the most effective and safest therapy for MGD.This review summarizes the physical therapy modalities of western medicine(WM)and traditiond Chinese medicine(TCM)for the treatment of MGD to provide optimal treatments for these patients and to further lay a foundation for mechanistic studies of MGD.
基金supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education(No.2019R1A6A1A03033215)supported by“Human Resources Program in Energy Technology”of the Korea Institute of Energy Technology Evaluation and Planning(KETEP),granted financial resource from the Ministry of Trade,Industry&Energy,Republic of Korea(No.20174030201800)。
文摘The study of photonic sintering has gained interest based on the advantages of fast processing at room temperature.However,printed electronics made from photonic sintering with an intensive pulsed light(IPL)energy source exhibit more mechanical instability than those made from conventional thermal sintering processes.To solve the mechanical instability problems,we fabricated Ag flake hybrid pastes with a variety of concentrations of Ag flake(0,25,50,75,and 100 wt.%).All of the screen-printed hybrid Ag circuits were fabricated on polyimide substrates and were sintered at 3.5 MW.Surface porosity was analyzed using the Brunauer-Emmett-Teller method.An IPC(Packaging Electronic Circuits)sliding test was performed to analyze the flexibility of the screen-printed Ag flake hybrid circuits.The adhesion strength of the hybrid circuits was evaluated with a roll-type 90°peel test.The hybrid Ag printed circuit showed improvements in both the flexibility and adhesion strength with the addition of Ag flake.
