PDRG1 is a small oncogenic protein of 133 residues. In normal human tissues, the p53 and DNA damageregulated gene 1(PDRG1) gene exhibits maximal expression in the testis and minimal levels in the liver. Increased expr...PDRG1 is a small oncogenic protein of 133 residues. In normal human tissues, the p53 and DNA damageregulated gene 1(PDRG1) gene exhibits maximal expression in the testis and minimal levels in the liver. Increased expression has been detected in several tumor cells and in response to genotoxic stress. High-throughput studies identified the PDRG1 protein in a variety of macromolecular complexes involved in processes that are altered in cancer cells. For example, this oncogene has been found as part of the RNA polymerase Ⅱ complex, the splicing machinery and nutrient sensing machinery, although its role in these complexes remains unclear. More recently, the PDRG1 protein was found as an interaction target for the catalytic subunits of methionine adenosyltransferases. These enzymes synthesize S-adenosylmethionine, the methyl donor for, among others, epigenetic methylations that occur on the DNA and histones. In fact, downregulation of S-adenosylmethionine synthesis is the first functional effect directly ascribed to PDRG1. The existence of global DNA hypomethylation, together with increased PDRG1 expression, in many tumor cells highlights the importance of this interaction as one of the putative underlying causes for cell transformation. Here, we will review the accumulated knowledge on this oncogene, emphasizing the numerous aspects that remain to be explored.展开更多
Online customers execute transactions without inspecting products could expect to encounter risks of receiving products with unsatisfactory qualities,especially in food trans-actions.Thus quality supervision plays a k...Online customers execute transactions without inspecting products could expect to encounter risks of receiving products with unsatisfactory qualities,especially in food trans-actions.Thus quality supervision plays a key role in the establishment of trust as well as in the management of risk between online customers and sellers.Most papers in this field are in qualitative nature.In this paper,a quality supervision profit(QSP)model is formulated as a discrete-time optimal control problem.It is a quantitative approach,and it broadens the scope.of current research in the area.The quality efort level of online sellers(QELa)and the quality supervision level of the electronic intermediary(QSLm)are considered together with their cor-responding profit in the proposed model.The aim is to optimize an overall profit.A case study arising from Suichang's food traceability system(FTS)of farm produce online transaction is carried out in details.The results reveal that QELs,QSLm and the profit distribution coeffi-cient have a strong influence upon the profits of both sides.Finally,some concluding remarks,including potential further research topics,are given.展开更多
Robot technology is expected to reduce the burden of medical professionals, a concern in the super-aged society. The aim of this article is to determine the intermediary roles of Public Health Nurses (PHNs) in using C...Robot technology is expected to reduce the burden of medical professionals, a concern in the super-aged society. The aim of this article is to determine the intermediary roles of Public Health Nurses (PHNs) in using Communication Robots (CRs) in Community Health care. It is necessary to consider who will manage, and how to draw lines of responsibility when a problem occurs when using robots in the future. Regarding the mediator or intermediary role of PHNs in the use of CRs, PHNs are expected to be cognizant of varieties of robots for use with persons of diverse ages and health levels, as well as of robot performances. As one of the community healthcare workers who service the elderly living in the community, the role of PHNs as mediators or intermediaries is to pay attention to ethical and moral issues while working with CRs to manage the health of the community. Lack of understanding of the intermediary role might create possible ethico-moral issues in the future. Therefore, it is critical for PHNs to understand their role as intermediaries. In doing so, it is expected that older people at home will be able to live peaceful lives, as well as be physically and mentally healthy.展开更多
This paper intends to clarify the needs serendipity in creating new business. The authors will show that serendipity is capability method of finding potential needs and/or new markets. In economic society, potential n...This paper intends to clarify the needs serendipity in creating new business. The authors will show that serendipity is capability method of finding potential needs and/or new markets. In economic society, potential needs and/or new markets are only partially exposed, such as an iceberg. Serendipity is a capability that can expose the potential hidden part through accidental opportunity. Something more concrete can be formed from the exposed parts. The authors describe cases that demonstrate the usefulness of serendipity. In one case, a high-tech start-up had intended to use medical electronic equipment and/or industrial electronic equipment as the first application of their core technology. In these markets, they were competing with established major companies, so this start-up had difficulty entering these markets. However, a specific distributor found potential needs that were met by the start-up＇s products, and has created a new market by combining their core technology with social needs. The authors define serendipity capability by analyzing this case example and argue that serendipity can contribute to finding opportunities and solving social issues.展开更多
This article analyzes the relationship between financial intermediary development and economic fluctuation in thelast 50 wars in China. It was found that a steady and long-term relation existed between these two varia...This article analyzes the relationship between financial intermediary development and economic fluctuation in thelast 50 wars in China. It was found that a steady and long-term relation existed between these two variables, and that differentaspects of the development of the financial intermediary system had different effects on the economic fluctuation. The improve-ment of the intermediary’s efficiency can repress the economic fluctuation, but the increase of financial intermediaries canintensify the fluctuation. On that basis, some suggestions about the development of the financial intermediary are proposed inthis essay.展开更多
Background High dietary carbohydrates can spare protein in rainbow trout(Oncorhynchus mykiss)but may affect growth and health.Inulin,a prebiotic,could have nutritional and metabolic effects,along with anti-inflammator...Background High dietary carbohydrates can spare protein in rainbow trout(Oncorhynchus mykiss)but may affect growth and health.Inulin,a prebiotic,could have nutritional and metabolic effects,along with anti-inflammatory properties in teleosts,improving growth and welfare.We tested this hypothesis in rainbow trout by feeding them a 100%plant-based diet,which is a viable alternative to fishmeal and fish oil in aquaculture feeds.In a two-factor design,we examined the impact of inulin(2%)as well as the variation in the carbohydrates(CHO)/plant protein ratio on rainbow trout.We assessed the influence of these factors on zootechnical parameters,plasma metabolites,gut microbiota,production of short-chain fatty acids and lactic acid,as well as the expression of free-fatty acid receptor genes in the mid-intestine,intermediary liver metabolism,and immune markers in a 12-week feeding trial.Results The use of 2%inulin did not significantly change the fish intestinal microbiota,but interestingly,the high CHO/protein ratio group showed a change in intestinal microbiota and in particular the beta diversity,with 21 bacterial genera affected,including Ralstonia,Bacillus,and 11 lactic-acid producing bacteria.There were higher levels of butyric,and valeric acid in groups fed with high CHO/protein diet but not with inulin.The high CHO/protein group showed a decrease in the expression of pro-inflammatory cytokines(il1b,il8,and tnfa)in liver and a lower expression of the genes coding for tight-junction proteins in mid-intestine(tjp1a and tjp3).However,the 2%inulin did not modify the expression of plasma immune markers.Finally,inulin induced a negative effect on rainbow trout growth performance irrespective of the dietary carbohydrates.Conclusions With a 100%plant-based diet,inclusion of high levels of carbohydrates could be a promising way for fish nutrition in aquaculture through a protein sparing effect whereas the supplementation of 2%inulin does not appear to improve the use of CHO when combined with a 100%plant-based diet.展开更多
基金support by the Ministerio Educación y CienciaMinisterio de Economía y Competitividad of Spain(until June 2013)
文摘PDRG1 is a small oncogenic protein of 133 residues. In normal human tissues, the p53 and DNA damageregulated gene 1(PDRG1) gene exhibits maximal expression in the testis and minimal levels in the liver. Increased expression has been detected in several tumor cells and in response to genotoxic stress. High-throughput studies identified the PDRG1 protein in a variety of macromolecular complexes involved in processes that are altered in cancer cells. For example, this oncogene has been found as part of the RNA polymerase Ⅱ complex, the splicing machinery and nutrient sensing machinery, although its role in these complexes remains unclear. More recently, the PDRG1 protein was found as an interaction target for the catalytic subunits of methionine adenosyltransferases. These enzymes synthesize S-adenosylmethionine, the methyl donor for, among others, epigenetic methylations that occur on the DNA and histones. In fact, downregulation of S-adenosylmethionine synthesis is the first functional effect directly ascribed to PDRG1. The existence of global DNA hypomethylation, together with increased PDRG1 expression, in many tumor cells highlights the importance of this interaction as one of the putative underlying causes for cell transformation. Here, we will review the accumulated knowledge on this oncogene, emphasizing the numerous aspects that remain to be explored.
基金Supported by Zhejiang Provincial basic public welfare research project of China(LGN19C040001)。
文摘Online customers execute transactions without inspecting products could expect to encounter risks of receiving products with unsatisfactory qualities,especially in food trans-actions.Thus quality supervision plays a key role in the establishment of trust as well as in the management of risk between online customers and sellers.Most papers in this field are in qualitative nature.In this paper,a quality supervision profit(QSP)model is formulated as a discrete-time optimal control problem.It is a quantitative approach,and it broadens the scope.of current research in the area.The quality efort level of online sellers(QELa)and the quality supervision level of the electronic intermediary(QSLm)are considered together with their cor-responding profit in the proposed model.The aim is to optimize an overall profit.A case study arising from Suichang's food traceability system(FTS)of farm produce online transaction is carried out in details.The results reveal that QELs,QSLm and the profit distribution coeffi-cient have a strong influence upon the profits of both sides.Finally,some concluding remarks,including potential further research topics,are given.
文摘Robot technology is expected to reduce the burden of medical professionals, a concern in the super-aged society. The aim of this article is to determine the intermediary roles of Public Health Nurses (PHNs) in using Communication Robots (CRs) in Community Health care. It is necessary to consider who will manage, and how to draw lines of responsibility when a problem occurs when using robots in the future. Regarding the mediator or intermediary role of PHNs in the use of CRs, PHNs are expected to be cognizant of varieties of robots for use with persons of diverse ages and health levels, as well as of robot performances. As one of the community healthcare workers who service the elderly living in the community, the role of PHNs as mediators or intermediaries is to pay attention to ethical and moral issues while working with CRs to manage the health of the community. Lack of understanding of the intermediary role might create possible ethico-moral issues in the future. Therefore, it is critical for PHNs to understand their role as intermediaries. In doing so, it is expected that older people at home will be able to live peaceful lives, as well as be physically and mentally healthy.
文摘This paper intends to clarify the needs serendipity in creating new business. The authors will show that serendipity is capability method of finding potential needs and/or new markets. In economic society, potential needs and/or new markets are only partially exposed, such as an iceberg. Serendipity is a capability that can expose the potential hidden part through accidental opportunity. Something more concrete can be formed from the exposed parts. The authors describe cases that demonstrate the usefulness of serendipity. In one case, a high-tech start-up had intended to use medical electronic equipment and/or industrial electronic equipment as the first application of their core technology. In these markets, they were competing with established major companies, so this start-up had difficulty entering these markets. However, a specific distributor found potential needs that were met by the start-up＇s products, and has created a new market by combining their core technology with social needs. The authors define serendipity capability by analyzing this case example and argue that serendipity can contribute to finding opportunities and solving social issues.
文摘This article analyzes the relationship between financial intermediary development and economic fluctuation in thelast 50 wars in China. It was found that a steady and long-term relation existed between these two variables, and that differentaspects of the development of the financial intermediary system had different effects on the economic fluctuation. The improve-ment of the intermediary’s efficiency can repress the economic fluctuation, but the increase of financial intermediaries canintensify the fluctuation. On that basis, some suggestions about the development of the financial intermediary are proposed inthis essay.
基金funded by the CD40 (Departmental Council of the Landes)the “Universitéde Pau et Pays de l’Adour “(UPPA)
文摘Background High dietary carbohydrates can spare protein in rainbow trout(Oncorhynchus mykiss)but may affect growth and health.Inulin,a prebiotic,could have nutritional and metabolic effects,along with anti-inflammatory properties in teleosts,improving growth and welfare.We tested this hypothesis in rainbow trout by feeding them a 100%plant-based diet,which is a viable alternative to fishmeal and fish oil in aquaculture feeds.In a two-factor design,we examined the impact of inulin(2%)as well as the variation in the carbohydrates(CHO)/plant protein ratio on rainbow trout.We assessed the influence of these factors on zootechnical parameters,plasma metabolites,gut microbiota,production of short-chain fatty acids and lactic acid,as well as the expression of free-fatty acid receptor genes in the mid-intestine,intermediary liver metabolism,and immune markers in a 12-week feeding trial.Results The use of 2%inulin did not significantly change the fish intestinal microbiota,but interestingly,the high CHO/protein ratio group showed a change in intestinal microbiota and in particular the beta diversity,with 21 bacterial genera affected,including Ralstonia,Bacillus,and 11 lactic-acid producing bacteria.There were higher levels of butyric,and valeric acid in groups fed with high CHO/protein diet but not with inulin.The high CHO/protein group showed a decrease in the expression of pro-inflammatory cytokines(il1b,il8,and tnfa)in liver and a lower expression of the genes coding for tight-junction proteins in mid-intestine(tjp1a and tjp3).However,the 2%inulin did not modify the expression of plasma immune markers.Finally,inulin induced a negative effect on rainbow trout growth performance irrespective of the dietary carbohydrates.Conclusions With a 100%plant-based diet,inclusion of high levels of carbohydrates could be a promising way for fish nutrition in aquaculture through a protein sparing effect whereas the supplementation of 2%inulin does not appear to improve the use of CHO when combined with a 100%plant-based diet.
