This study aims to evaluate the therapeutic effects of laser acupuncture(LA)on articular cartilage degradation at the early stage of postmenopausal osteoarthritis(PMOA)by an ultrasound biomicroscopic technology.Twenty...This study aims to evaluate the therapeutic effects of laser acupuncture(LA)on articular cartilage degradation at the early stage of postmenopausal osteoarthritis(PMOA)by an ultrasound biomicroscopic technology.Twentyone healthy female Sprague-Dawley rats were randomly and evenly divided into three groups-sham,ovariectomized(OVX)and OVXþLA groups.Only the peri-ovarian fatty tissue of the sham rats was exteriorized.The animals in the OVX and OVXþLA groups underwent bilateral ovariectomy to create a menopause model.On day 8 after the ovariectomy,the 2-week LA therapy at acupoints Guanyuan(CV-4),Sanyinjiao(SP-6),and Zusanli(ST36)was performed in the OVXþLA group,while the sham and OVX groups had a sham treatment.All the animals were sacrificed on day 22.The cartilage tissues in the left knee joint were examined by ultrasound and histology.Compared with the sham group,the significantly degenerate alterations(p<0.01)in ultrasound roughness index(URI),reflection coefficient(RC1)and cartilage thickness were found in the OVX group,while the values of these parameters were significantly recovered(p<0.01)in the OVXþLA group.The LA treatment enhanced proteoglycans(PGs)content with a significant reduce of the modified Mankin score(p<0.01).The acoustic assessment strongly correlated with the histologic evaluation.The results showed that LA treatment could alleviate the postmenopause-induced cartilage degradation and promote tissue repair.LA has potential to be a simple and safe non-pharmacological countermeasure against PMOA for geriatric patient population.The ultrasound biomicroscopic technology could be a quantitative evaluation tool of the structural and morphological responses of articular cartilage to LA intervention.展开更多
Photobiomodulation(PBM)therapy is a therapeutic method that can produce a range of physiological effects in cells and tissues using certain wavelengths.The reparative benefits of PBM therapy include wound healing,bone...Photobiomodulation(PBM)therapy is a therapeutic method that can produce a range of physiological effects in cells and tissues using certain wavelengths.The reparative benefits of PBM therapy include wound healing,bone regeneration,pain reduction,and the mitigation of inflammation.Advances in the development of laser instruments,including the use of high-intensity lasers in physiotherapy,have recently led to controllable photothermal and photomechanical treatments that enable therapeutic effects to be obtained without damaging tissue.The combination of PBM therapy with acupuncture may provide new perspectives for investigating the underlying therapeutic mechanisms of acupuncture and promote its widespread application.展开更多
Objective To observe the clinical therapeutic effect of laser acupuncture on type 2 diabetes mellitus(T2DM)of qi and yin deficiency type.Methods Laser acupuncture was used to treat 32 patients of T2DM.Acupoint selecti...Objective To observe the clinical therapeutic effect of laser acupuncture on type 2 diabetes mellitus(T2DM)of qi and yin deficiency type.Methods Laser acupuncture was used to treat 32 patients of T2DM.Acupoint selection:Fèishū(肺俞BL13),Píshū(脾俞BL20),Shènshū(肾俞BL23),Wǎnxiàshū(胃脘下俞EX-B3),Sānyīnjiāo(三阴交SP6)and Zúsānlĭ足三里(ST36).It took 20 min in each treatment,five treatments a week.There were 2 days of interval in 2 weeks of treatment.Before and after treatment,the changes in fasting plasma glucose(FPG),postprandial 2 h glucose(2hPG),fasting insulin(FINS),glycosylated albumin(GA),insulin resistance index(HOMA-IR)and the symptom score of traditional Chinese medicine(TCM)were observed in the patients.The therapeutic effect was evaluated.Results Of 32 cases,8 cases were remarkably effective,18 cases effective and 6 cases failed.The total effective rate was 81.3%.At the end of treatment course,the level of every indicator after treatment was significantly lower than that before treatment(all P<0.01).Conclusion Laser acupuncture achieves the significant therapeutic effect on T2DM of qi and yin deficiency and this therapy deserves to be promoted in clinical application.展开更多
基金the Special Funds of Guang Dong Universities for Talents(2050205)the Guangdong Science and Technology Program(grant no.2016A020216017)。
文摘This study aims to evaluate the therapeutic effects of laser acupuncture(LA)on articular cartilage degradation at the early stage of postmenopausal osteoarthritis(PMOA)by an ultrasound biomicroscopic technology.Twentyone healthy female Sprague-Dawley rats were randomly and evenly divided into three groups-sham,ovariectomized(OVX)and OVXþLA groups.Only the peri-ovarian fatty tissue of the sham rats was exteriorized.The animals in the OVX and OVXþLA groups underwent bilateral ovariectomy to create a menopause model.On day 8 after the ovariectomy,the 2-week LA therapy at acupoints Guanyuan(CV-4),Sanyinjiao(SP-6),and Zusanli(ST36)was performed in the OVXþLA group,while the sham and OVX groups had a sham treatment.All the animals were sacrificed on day 22.The cartilage tissues in the left knee joint were examined by ultrasound and histology.Compared with the sham group,the significantly degenerate alterations(p<0.01)in ultrasound roughness index(URI),reflection coefficient(RC1)and cartilage thickness were found in the OVX group,while the values of these parameters were significantly recovered(p<0.01)in the OVXþLA group.The LA treatment enhanced proteoglycans(PGs)content with a significant reduce of the modified Mankin score(p<0.01).The acoustic assessment strongly correlated with the histologic evaluation.The results showed that LA treatment could alleviate the postmenopause-induced cartilage degradation and promote tissue repair.LA has potential to be a simple and safe non-pharmacological countermeasure against PMOA for geriatric patient population.The ultrasound biomicroscopic technology could be a quantitative evaluation tool of the structural and morphological responses of articular cartilage to LA intervention.
基金financially supported by Beijing Municipal Administration of Hospitals Incubating Program,Code:PZ2021001。
文摘Photobiomodulation(PBM)therapy is a therapeutic method that can produce a range of physiological effects in cells and tissues using certain wavelengths.The reparative benefits of PBM therapy include wound healing,bone regeneration,pain reduction,and the mitigation of inflammation.Advances in the development of laser instruments,including the use of high-intensity lasers in physiotherapy,have recently led to controllable photothermal and photomechanical treatments that enable therapeutic effects to be obtained without damaging tissue.The combination of PBM therapy with acupuncture may provide new perspectives for investigating the underlying therapeutic mechanisms of acupuncture and promote its widespread application.
基金Supported by Second Batch of Jiangsu Province Veteran Inheritance Studio Construction Project:2016607Third Batch of Jiangsu Province Chinese Medicine Clinical Outstanding Talent Research Project:Jiangsu TCM Science&Education[2017]No.18。
文摘Objective To observe the clinical therapeutic effect of laser acupuncture on type 2 diabetes mellitus(T2DM)of qi and yin deficiency type.Methods Laser acupuncture was used to treat 32 patients of T2DM.Acupoint selection:Fèishū(肺俞BL13),Píshū(脾俞BL20),Shènshū(肾俞BL23),Wǎnxiàshū(胃脘下俞EX-B3),Sānyīnjiāo(三阴交SP6)and Zúsānlĭ足三里(ST36).It took 20 min in each treatment,five treatments a week.There were 2 days of interval in 2 weeks of treatment.Before and after treatment,the changes in fasting plasma glucose(FPG),postprandial 2 h glucose(2hPG),fasting insulin(FINS),glycosylated albumin(GA),insulin resistance index(HOMA-IR)and the symptom score of traditional Chinese medicine(TCM)were observed in the patients.The therapeutic effect was evaluated.Results Of 32 cases,8 cases were remarkably effective,18 cases effective and 6 cases failed.The total effective rate was 81.3%.At the end of treatment course,the level of every indicator after treatment was significantly lower than that before treatment(all P<0.01).Conclusion Laser acupuncture achieves the significant therapeutic effect on T2DM of qi and yin deficiency and this therapy deserves to be promoted in clinical application.
