Based on the MTLL lightning return stroke model,a two-dimensional cylindrical finite-difference time-domain( FDTD) model for underground horizontal electric field was established,and the effects of distance from light...Based on the MTLL lightning return stroke model,a two-dimensional cylindrical finite-difference time-domain( FDTD) model for underground horizontal electric field was established,and the effects of distance from lightning channel,depth,soil electrical conductivity and its distribution,and return stroke current on the characteristics of underground horizontal electric field were analyzed. The results showed that as long as the electrical conductivity of soil existed,the peak of underground horizontal electric field decreased with the increase in the horizontal distance from lightning channel. When the electrical conductivity of the upper soil was much smaller than that of the lower soil,the peak of corresponding horizontal electric field was larger than the electric field peak as the electrical conductivity of the upper soil was larger than that of the lower soil. When the electrical conductivity of the upper soil was less than that of the lower soil,the growth and decay of the horizontal electric field were faster than the growth and decay as the electrical conductivity of the upper soil was larger than that of the lower soil.展开更多
To resolve the impact of transient high frequency signals induced by lightning stroke on the travelling wave protection of transmission line, a novel identification algorithm is proposed. Using the characteristics of ...To resolve the impact of transient high frequency signals induced by lightning stroke on the travelling wave protection of transmission line, a novel identification algorithm is proposed. Using the characteristics of symmetric current wave-form induced by lightning stroke without causing fault and that of asymmetric current waveform generated by fault within a very short time interval, the waveform of transient current above and below time-axes are integrated respec-tively. First, through comparing the relative ratio of them with threshold value, the primary criterion identifying fault and lightning stroke is constructed;Secondly, to improve the reliability of discrimination between lightning stroke with and without causing fault, according to the difference of them, the secondary criterion is also defined. The simulation results and analysis demonstrate that the proposed integral criterions are valid and correct.展开更多
<b>Objective:</b> The objective is to investigate whether acupuncture can protect brain by regulating the expression of ICAM-5 mRNA in brain tissue. <b>Methods:</b> Male SD rats were used to co...<b>Objective:</b> The objective is to investigate whether acupuncture can protect brain by regulating the expression of ICAM-5 mRNA in brain tissue. <b>Methods:</b> Male SD rats were used to construct a middle cerebral artery occlusion reperfusion injury (Middle cerebral artery occlusion, MCAO) model, and the rats were randomly divided into 4 groups, namely the normal group (group A) and the sham operation group (group B), MCAO group (group C), MCAO + acupuncture group (group D);real-time fluorescent quantitative PCR (RT-qPCR) was used to detect the expression of ICAM-5 mRNA in the brain tissue of the ischemic area, and HE staining and TUNEL were used to detect the level of neuronal apoptosis to evaluate the therapeutic effect. <b>Results:</b> Acupuncture can improve neuronal morphology and reduce neuronal apoptosis in rats with ischemic stroke. RT-qPCR: compared with group A and group B, the expression level of ICAM-5 mRNA in the brain tissues of group C and group D decreased, while compared with group C, The expression of ICAM-5 mRNA in the brain tissue of group D was significantly up-regulated (P < 0.05). There was no statistical difference between group A and group B (P > 0.05). <b>Conclusion:</b> The effectiveness of acupuncture in the treatment of ischemic stroke may achieve neuroprotection by up-regulating the expression level of ICAM-5 mRNA.展开更多
Objective: To investigate the effects of safflower yellow pigment combined with cerebellin on neurological function in patients with ischemic stroke and analyze its possible mechanism. Methods: A total of 130 patients...Objective: To investigate the effects of safflower yellow pigment combined with cerebellin on neurological function in patients with ischemic stroke and analyze its possible mechanism. Methods: A total of 130 patients with ischemic stroke admitted to my hospital from May 2017 to August 2018 were enrolled. The patients were divided into the control group and the study group according to the random number table method, 65 cases in each group. The control group was treated with cerebroside carnosine. And the study group was treated with safflower yellow pigment on the basis of the control group. The changes of neurological function index, oxidative stress index, vascular endothelial function index and inflammatory factor were compared before and after treatment. Results: There were no significant differences in preoperative neurological parameters, oxidative stress, vascular endothelial function and inflammatory factors between the two groups (P>0.05). After treatment, the neurological function indexes S-100β and NSE were significantly lower in both groups, and NGF levels were significantly increased. The S-100β and NSE levels in the study group were (0.91±0.10) ng/L and (12.91±1.33) ng/L, respectively, which were significantly lower than control group. While the NGF level of the study group was (79.52±8.07) μg/L significantly higher than that of the control group (both P<0.05). The levels of Ox-LDL were significantly reduced and GSH-Px levels were significantly elevated in both groups after treatment. The level of oxidative stress index Ox-LDL was (563.51±57.10) μg/dL, which was significantly lower than that of the control group, and the GSH-Px level was (154.55±16.07) U/L, which was significantly higher than the control group (both P<0.05). The levels of vascular endothelial function NT-proBNP, TXB2 and ET-1 were significantly lower in the two groups after treatment. The NT-proBNP, TXB2 and ET-1 in the study group were (95.91±9.77) pg/mL, (245.69±25.06) pg/mL and (64.26±6.65) ng/L, respectively, which were significantly lower than the control group (both P<0.05). The levels of inflammatory factors MMP-9 and TNF-α were significantly lower in the two groups after treatment. The levels of MMP-9 and TNF-α in the study group were (60.64±6.12) ng/mL and (0.33±0.04) ng/mL, respectively, which were significantly lower than those in the control group (both P<0.05). Conclusion: Safflor yellow combined with cerebellin in the treatment of ischemic stroke has higher clinical efficacy and can significantly improve the neurological function of patients. The possible mechanism is related to the improvement of vascular endothelial function and stress response.展开更多
A case of villagers suffering lightning stroke around the tower of a mobile communication base station was investigated to analyze its reasons,and the countermeasures against lightning stroke were proposed. The result...A case of villagers suffering lightning stroke around the tower of a mobile communication base station was investigated to analyze its reasons,and the countermeasures against lightning stroke were proposed. The results show that the lightning stroke event is related to dispersed lightning stroke. To avoid the damage caused by lightning stroke,it is needed to equip a house in the dispersed lightning stroke zone with lightning protection system and spread lightning protection knowledge among the villagers.展开更多
Introduction Lightning can cause great destruction. According to the record in the northern China, more than 150 lightning strokes occur on a power system annually. High voltage (millions of volts) and large current (...Introduction Lightning can cause great destruction. According to the record in the northern China, more than 150 lightning strokes occur on a power system annually. High voltage (millions of volts) and large current (hundreds of -kA) associated with lightning, will damage property and even kill people and livestocks. It will be very dangerous if a lightning stroke strikes oil depot of power plant or substation. In addition, the high voltage induced by the electrostatic charge generated due to oil flowing will probably cause damage unless the electrification has been limited and drained off.展开更多
At present,ischemic stroke seriously affects people's life and health,and its occurrence,development and therapeutic effect are affected by many factors.With the deep research on ischemic cerebral apoplexy disease...At present,ischemic stroke seriously affects people's life and health,and its occurrence,development and therapeutic effect are affected by many factors.With the deep research on ischemic cerebral apoplexy disease,people have a deeper understanding of its virulence genes.The apolipoprotein E genotype is the research focus recently,its genetic type is not only involved in the occurrence and development of ischemic cerebral apoplexy,but also causes different therapeatic effects.In this paper,we reviewed the relationship between apolipoprotein E gene polymorphism and lipid metabolism and atherosclerosis in ischemic stroke,as well as the differences in the therapeutic effects of thrombolysis,thrombectomy and lipid-lowering among different genotypes.展开更多
Acute ischemic stroke is one of the common discases in Chinese,among which acute ischemic stroke with large vessel occlusion(AIS-LVO)has thc most serious complications and has the risk of death.Studies have shown that...Acute ischemic stroke is one of the common discases in Chinese,among which acute ischemic stroke with large vessel occlusion(AIS-LVO)has thc most serious complications and has the risk of death.Studies have shown that reperfusion is a first-line treatment for the effective rescue of ischemic brain tissue,usually mainly by mechanical|hrombectomy(MT),supplemented by intravenous thrombolysis.However,there are still complications after large blood vessel occlusion and MT.such as blecding and infection at the puncture point,vasospasm,vascular dissection,subarachnoid hemorrhage,hcmonhagic transfomation,reembolization,and massive cerebral infarction,ctc.The high risk factors and corresponding measures of complications after MT by revicwing the rescarch analysis.展开更多
BACKGROUND Mechanical thrombectomy is the most effective treatment for great cerebral artery embolization within a set time window.Typically,an arteriogram does not show the localization of the stent after release and...BACKGROUND Mechanical thrombectomy is the most effective treatment for great cerebral artery embolization within a set time window.Typically,an arteriogram does not show the localization of the stent after release and whether a thrombus is captured or not.Thus,improving the visualization of a stent in interventional therapy will be helpful for clinicians.AIM To analyze stent imaging findings to enhance clinicians’understanding of a special circumstance,wherein a Solitaire AB retrievable stent was visible during the imaging of a thrombus capture that improved the success rate of stent-based mechanical thrombectomy.METHODS This was a retrospective study with four acute ischemic stroke(AIS)patients who underwent stent-based mechanical thrombectomy.RESULTS Patient 1 was a 64-year-old man admitted after 5 h of confusion;angiography revealed basilar artery occlusion.We inserted a stent into the left posterior cerebral artery-P2 segment and visualized the expanded stent that successfully captured a thrombus.Patient 2 was a 74-year-old man admitted with confusion,which lasted approximately 3 h.Angiography revealed a left middle cerebral artery(MCA)-M1 segment occlusion.A stent was deployed in the distal M2 segment,and we could visualize the stent by capturing the thrombus.Patient 3 was a 74-year-old woman admitted after experiencing left hemiplegia for 3 h.We deployed a stent at the distal right MCAM2 segment,and the developing stent captured a large thrombus.Patient 4 was an 82-year-old man who presented with confusion for 3 h.A developing stent was placed in the distal left MCA-M1 segment,which captured a large thrombus and several fragmented thrombi.CONCLUSION To the best of our knowledge,this is the first report of stent imaging in patients with AIS.We demonstrated the usefulness and substantial potential of stent imaging in stent-based mechanical thrombectomy for AIS.展开更多
文摘Based on the MTLL lightning return stroke model,a two-dimensional cylindrical finite-difference time-domain( FDTD) model for underground horizontal electric field was established,and the effects of distance from lightning channel,depth,soil electrical conductivity and its distribution,and return stroke current on the characteristics of underground horizontal electric field were analyzed. The results showed that as long as the electrical conductivity of soil existed,the peak of underground horizontal electric field decreased with the increase in the horizontal distance from lightning channel. When the electrical conductivity of the upper soil was much smaller than that of the lower soil,the peak of corresponding horizontal electric field was larger than the electric field peak as the electrical conductivity of the upper soil was larger than that of the lower soil. When the electrical conductivity of the upper soil was less than that of the lower soil,the growth and decay of the horizontal electric field were faster than the growth and decay as the electrical conductivity of the upper soil was larger than that of the lower soil.
文摘To resolve the impact of transient high frequency signals induced by lightning stroke on the travelling wave protection of transmission line, a novel identification algorithm is proposed. Using the characteristics of symmetric current wave-form induced by lightning stroke without causing fault and that of asymmetric current waveform generated by fault within a very short time interval, the waveform of transient current above and below time-axes are integrated respec-tively. First, through comparing the relative ratio of them with threshold value, the primary criterion identifying fault and lightning stroke is constructed;Secondly, to improve the reliability of discrimination between lightning stroke with and without causing fault, according to the difference of them, the secondary criterion is also defined. The simulation results and analysis demonstrate that the proposed integral criterions are valid and correct.
文摘<b>Objective:</b> The objective is to investigate whether acupuncture can protect brain by regulating the expression of ICAM-5 mRNA in brain tissue. <b>Methods:</b> Male SD rats were used to construct a middle cerebral artery occlusion reperfusion injury (Middle cerebral artery occlusion, MCAO) model, and the rats were randomly divided into 4 groups, namely the normal group (group A) and the sham operation group (group B), MCAO group (group C), MCAO + acupuncture group (group D);real-time fluorescent quantitative PCR (RT-qPCR) was used to detect the expression of ICAM-5 mRNA in the brain tissue of the ischemic area, and HE staining and TUNEL were used to detect the level of neuronal apoptosis to evaluate the therapeutic effect. <b>Results:</b> Acupuncture can improve neuronal morphology and reduce neuronal apoptosis in rats with ischemic stroke. RT-qPCR: compared with group A and group B, the expression level of ICAM-5 mRNA in the brain tissues of group C and group D decreased, while compared with group C, The expression of ICAM-5 mRNA in the brain tissue of group D was significantly up-regulated (P < 0.05). There was no statistical difference between group A and group B (P > 0.05). <b>Conclusion:</b> The effectiveness of acupuncture in the treatment of ischemic stroke may achieve neuroprotection by up-regulating the expression level of ICAM-5 mRNA.
文摘Objective: To investigate the effects of safflower yellow pigment combined with cerebellin on neurological function in patients with ischemic stroke and analyze its possible mechanism. Methods: A total of 130 patients with ischemic stroke admitted to my hospital from May 2017 to August 2018 were enrolled. The patients were divided into the control group and the study group according to the random number table method, 65 cases in each group. The control group was treated with cerebroside carnosine. And the study group was treated with safflower yellow pigment on the basis of the control group. The changes of neurological function index, oxidative stress index, vascular endothelial function index and inflammatory factor were compared before and after treatment. Results: There were no significant differences in preoperative neurological parameters, oxidative stress, vascular endothelial function and inflammatory factors between the two groups (P>0.05). After treatment, the neurological function indexes S-100β and NSE were significantly lower in both groups, and NGF levels were significantly increased. The S-100β and NSE levels in the study group were (0.91±0.10) ng/L and (12.91±1.33) ng/L, respectively, which were significantly lower than control group. While the NGF level of the study group was (79.52±8.07) μg/L significantly higher than that of the control group (both P<0.05). The levels of Ox-LDL were significantly reduced and GSH-Px levels were significantly elevated in both groups after treatment. The level of oxidative stress index Ox-LDL was (563.51±57.10) μg/dL, which was significantly lower than that of the control group, and the GSH-Px level was (154.55±16.07) U/L, which was significantly higher than the control group (both P<0.05). The levels of vascular endothelial function NT-proBNP, TXB2 and ET-1 were significantly lower in the two groups after treatment. The NT-proBNP, TXB2 and ET-1 in the study group were (95.91±9.77) pg/mL, (245.69±25.06) pg/mL and (64.26±6.65) ng/L, respectively, which were significantly lower than the control group (both P<0.05). The levels of inflammatory factors MMP-9 and TNF-α were significantly lower in the two groups after treatment. The levels of MMP-9 and TNF-α in the study group were (60.64±6.12) ng/mL and (0.33±0.04) ng/mL, respectively, which were significantly lower than those in the control group (both P<0.05). Conclusion: Safflor yellow combined with cerebellin in the treatment of ischemic stroke has higher clinical efficacy and can significantly improve the neurological function of patients. The possible mechanism is related to the improvement of vascular endothelial function and stress response.
文摘A case of villagers suffering lightning stroke around the tower of a mobile communication base station was investigated to analyze its reasons,and the countermeasures against lightning stroke were proposed. The results show that the lightning stroke event is related to dispersed lightning stroke. To avoid the damage caused by lightning stroke,it is needed to equip a house in the dispersed lightning stroke zone with lightning protection system and spread lightning protection knowledge among the villagers.
文摘Introduction Lightning can cause great destruction. According to the record in the northern China, more than 150 lightning strokes occur on a power system annually. High voltage (millions of volts) and large current (hundreds of -kA) associated with lightning, will damage property and even kill people and livestocks. It will be very dangerous if a lightning stroke strikes oil depot of power plant or substation. In addition, the high voltage induced by the electrostatic charge generated due to oil flowing will probably cause damage unless the electrification has been limited and drained off.
基金Major Science and Technology Project of Hainan Province(ZDKJ202004)。
文摘At present,ischemic stroke seriously affects people's life and health,and its occurrence,development and therapeutic effect are affected by many factors.With the deep research on ischemic cerebral apoplexy disease,people have a deeper understanding of its virulence genes.The apolipoprotein E genotype is the research focus recently,its genetic type is not only involved in the occurrence and development of ischemic cerebral apoplexy,but also causes different therapeatic effects.In this paper,we reviewed the relationship between apolipoprotein E gene polymorphism and lipid metabolism and atherosclerosis in ischemic stroke,as well as the differences in the therapeutic effects of thrombolysis,thrombectomy and lipid-lowering among different genotypes.
基金High Level Talent Program of Hainan Natural Science Foundation(No.821RC680)。
文摘Acute ischemic stroke is one of the common discases in Chinese,among which acute ischemic stroke with large vessel occlusion(AIS-LVO)has thc most serious complications and has the risk of death.Studies have shown that reperfusion is a first-line treatment for the effective rescue of ischemic brain tissue,usually mainly by mechanical|hrombectomy(MT),supplemented by intravenous thrombolysis.However,there are still complications after large blood vessel occlusion and MT.such as blecding and infection at the puncture point,vasospasm,vascular dissection,subarachnoid hemorrhage,hcmonhagic transfomation,reembolization,and massive cerebral infarction,ctc.The high risk factors and corresponding measures of complications after MT by revicwing the rescarch analysis.
基金The Clinical Research Project of The First Affiliated Hospital of Shenzhen University,No.20223357030 and No.20223357021the“Double-First Class”Application Characteristic Discipline of Hunan Province(Pharmaceutical Science).
文摘BACKGROUND Mechanical thrombectomy is the most effective treatment for great cerebral artery embolization within a set time window.Typically,an arteriogram does not show the localization of the stent after release and whether a thrombus is captured or not.Thus,improving the visualization of a stent in interventional therapy will be helpful for clinicians.AIM To analyze stent imaging findings to enhance clinicians’understanding of a special circumstance,wherein a Solitaire AB retrievable stent was visible during the imaging of a thrombus capture that improved the success rate of stent-based mechanical thrombectomy.METHODS This was a retrospective study with four acute ischemic stroke(AIS)patients who underwent stent-based mechanical thrombectomy.RESULTS Patient 1 was a 64-year-old man admitted after 5 h of confusion;angiography revealed basilar artery occlusion.We inserted a stent into the left posterior cerebral artery-P2 segment and visualized the expanded stent that successfully captured a thrombus.Patient 2 was a 74-year-old man admitted with confusion,which lasted approximately 3 h.Angiography revealed a left middle cerebral artery(MCA)-M1 segment occlusion.A stent was deployed in the distal M2 segment,and we could visualize the stent by capturing the thrombus.Patient 3 was a 74-year-old woman admitted after experiencing left hemiplegia for 3 h.We deployed a stent at the distal right MCAM2 segment,and the developing stent captured a large thrombus.Patient 4 was an 82-year-old man who presented with confusion for 3 h.A developing stent was placed in the distal left MCA-M1 segment,which captured a large thrombus and several fragmented thrombi.CONCLUSION To the best of our knowledge,this is the first report of stent imaging in patients with AIS.We demonstrated the usefulness and substantial potential of stent imaging in stent-based mechanical thrombectomy for AIS.
文摘目的采用网络药理学方法探究益气活血方脑络欣通治疗缺血性脑卒中(ischemic stroke,IS)的作用机制,并通过分子对接技术进行初步验证。方法通过TCMSP、ETCM、化学专业数据库及文献筛选脑络欣通活性成分及作用靶点,通过OMIM、DisGeNET、GeneCards以及Drugbank数据库挖掘IS相关靶点;将交集靶点导入STRING平台和Cytoscape 3.8.2软件构建PPI网络并通过拓扑分析获得核心靶点,同时构建“中药—活性成分—核心靶点—疾病”可视化网络图;运用R软件进行GO功能及KEGG通路富集分析。最后借助Auto Dock Tools软件以及PyMOL软件进行分子对接和可视化。结果脑络欣通的潜在活性成分78个,治疗IS的潜在作用靶点200个,核心靶点包括STAT3、JUN、MAPK1、TP53等;作用较突出的活性成分包括槲皮素、β-谷甾醇、山柰酚、木犀草素等。进一步的生物功能分析获得150条信号通路,包括PI3K-AKT信号通路、HIF-1信号通路、FoxO信号通路等关键通路。分子对接结果表明关键活性成分与核心靶点之间存在分子结合位点,并有较强的结合活性。结论益气活血方脑络欣通可能是通过多成分、多靶点协同作用于氧化应激、炎症反应、细胞凋亡、自噬等生理病理环节,从而发挥治疗IS的作用。
