lipid-lowering interventions on the disease.Methods:Two-sample Mendelian randomization analyses were conducted to evaluate the associations of high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,t...lipid-lowering interventions on the disease.Methods:Two-sample Mendelian randomization analyses were conducted to evaluate the associations of high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,triglycerides,apolipoprotein B and apolipoprotein A-I levels with risks for sepsis,and those of low-density lipoprotein cholesterol(HMGCR,PCSK9,NPC1L1),triglycerides(LPL,ANGPTL3,APOC3)and high-density lipoprotein cholesterol(CETP),apolipoprotein A-I(CETP),apolipoprotein B(HMGCR,PCSK9,NPC1L1,LPL,APOC3)with sepsis.Results:HMGCR-mediated low-density lipoprotein cholesterol and apolipoprotein B were associated with an increased risk of sepsis,with an odds ratio value of 1.4(95%confidence interval(CI):1.06-1.84,P=0.017)and 1.41(95%CI:1.01-1.98,P=0.046).CETP-mediated high-density lipoprotein cholesterol and apolipoprotein A-I were associated with a reduced risk of sepsis,with an odds ratio of 0.87(95%CI:0.82-0.92,P<0.01)respectively and 0.84(95%CI:0.78-0.9,P<0.01).Sensitivity analysis showed that the results were robust.Conclusion:HMG-CoA reductase inhibitors and CETP inhibitors may contribute to the prevention and treatment of sepsis.展开更多
Background Statins are lipid-lowering drugs that are used widely around the world to treat and prevent cardiovascular diseases. Rare, but potentially fatal, cases of rhabdomyolysis(RM) have linked to the use of statin...Background Statins are lipid-lowering drugs that are used widely around the world to treat and prevent cardiovascular diseases. Rare, but potentially fatal, cases of rhabdomyolysis(RM) have linked to the use of statins,especially in the presence of other risk factors. Methods We retrospectively analyzed the causes, clinical characteristics, treatments and prognosis of RM patients who were hospitalized between January 2005 and March2016 at the Guangdong General Hospital, China. A total of 16 patients were included in the study(12 males and four females, mean age 60.69 years). Amongst the patients, there were three cases of coronary heart disease, eight cases of dilated cardiomyopathy, six cases of atrial fibrillation, one case of pulmonary embolism, one case of aortic dissection, six cases of hypertension and one case of paroxysmal ventricular tachycardia. All patients had some degree of liver and kidney dysfunction, with low hemoglobin and myoglobinuria. Seven patients had a fever and four had relevant neurological signs. All patients had digestive disorders and muscle weakness or pain during their stay in hospital. All patients received renal replacement therapy and 13 were placed on a ventilator to support breathing. Nine patients were eventually improved but seven patients died despite treatment. Results All sixteen cases of RM were associated with lipid-lowering drugs, with 14 patients taking statins and two patients taking fibrates. Conclusions Statins were the main cause of RM in patients with poor prognosis and high mortality rate.展开更多
基金The 2022 Educational Teaching Reform and Research Project of Guangxi University of Traditional Chinese Medicine(2022C032).
文摘lipid-lowering interventions on the disease.Methods:Two-sample Mendelian randomization analyses were conducted to evaluate the associations of high-density lipoprotein cholesterol,low-density lipoprotein cholesterol,triglycerides,apolipoprotein B and apolipoprotein A-I levels with risks for sepsis,and those of low-density lipoprotein cholesterol(HMGCR,PCSK9,NPC1L1),triglycerides(LPL,ANGPTL3,APOC3)and high-density lipoprotein cholesterol(CETP),apolipoprotein A-I(CETP),apolipoprotein B(HMGCR,PCSK9,NPC1L1,LPL,APOC3)with sepsis.Results:HMGCR-mediated low-density lipoprotein cholesterol and apolipoprotein B were associated with an increased risk of sepsis,with an odds ratio value of 1.4(95%confidence interval(CI):1.06-1.84,P=0.017)and 1.41(95%CI:1.01-1.98,P=0.046).CETP-mediated high-density lipoprotein cholesterol and apolipoprotein A-I were associated with a reduced risk of sepsis,with an odds ratio of 0.87(95%CI:0.82-0.92,P<0.01)respectively and 0.84(95%CI:0.78-0.9,P<0.01).Sensitivity analysis showed that the results were robust.Conclusion:HMG-CoA reductase inhibitors and CETP inhibitors may contribute to the prevention and treatment of sepsis.
基金supported by the grants from Guangdong Natural Science Foundation(No.2015A030313660)the Technology Project Foundation of Guangzhou(No.2014y2-00140/No.1563000381)the Technology Project Foundation of Guangdong Province(No.2014B020212008/No.2007B031500010)
文摘Background Statins are lipid-lowering drugs that are used widely around the world to treat and prevent cardiovascular diseases. Rare, but potentially fatal, cases of rhabdomyolysis(RM) have linked to the use of statins,especially in the presence of other risk factors. Methods We retrospectively analyzed the causes, clinical characteristics, treatments and prognosis of RM patients who were hospitalized between January 2005 and March2016 at the Guangdong General Hospital, China. A total of 16 patients were included in the study(12 males and four females, mean age 60.69 years). Amongst the patients, there were three cases of coronary heart disease, eight cases of dilated cardiomyopathy, six cases of atrial fibrillation, one case of pulmonary embolism, one case of aortic dissection, six cases of hypertension and one case of paroxysmal ventricular tachycardia. All patients had some degree of liver and kidney dysfunction, with low hemoglobin and myoglobinuria. Seven patients had a fever and four had relevant neurological signs. All patients had digestive disorders and muscle weakness or pain during their stay in hospital. All patients received renal replacement therapy and 13 were placed on a ventilator to support breathing. Nine patients were eventually improved but seven patients died despite treatment. Results All sixteen cases of RM were associated with lipid-lowering drugs, with 14 patients taking statins and two patients taking fibrates. Conclusions Statins were the main cause of RM in patients with poor prognosis and high mortality rate.
