In this paper we prove the local well-posedness of strong solutions to a chemotaxisshallow water system with initial vacuum in a bounded domainΩ■R^(2)without the standard compatibility condition for the initial data...In this paper we prove the local well-posedness of strong solutions to a chemotaxisshallow water system with initial vacuum in a bounded domainΩ■R^(2)without the standard compatibility condition for the initial data.This improves some results obtained in[J.Differential Equations 261(2016),6758-6789].展开更多
This paper is concerned with the Cauchy problem of a seventh order dispersive equation. We prove local well-posedness with initial data in Sobolev spaces Hs（R） for negative indices of s〉-114 .
This article is concerned with the 3 D nonhomogeneous incompressible magnetohydrodynamics equations with a slip boundary conditions in bounded domain.We obtain weighted estimates of the velocity and magnetic field,and...This article is concerned with the 3 D nonhomogeneous incompressible magnetohydrodynamics equations with a slip boundary conditions in bounded domain.We obtain weighted estimates of the velocity and magnetic field,and address the issue of local existence and uniqueness of strong solutions with the weaker initial data which contains vacuum states.展开更多
In this paper,we consider a model of compressible isentropic two-fluid magneto-hydrodynamics without resistivity in a strip domain in three dimensional space.By exploiting the two-tier energy method developed in[Anal ...In this paper,we consider a model of compressible isentropic two-fluid magneto-hydrodynamics without resistivity in a strip domain in three dimensional space.By exploiting the two-tier energy method developed in[Anal PDE,2013,6:1429–1533],we prove the global well-posedness of the governing model around a uniform magnetic field which is non-parallel to the horizontal boundary.Moreover,we show that the solution converges to the steady state at an almost exponential rate as time goes to infinity.Compared to the work of Tan and Wang[SIAM J Math Anal,2018,50:1432–1470],we need to overcome the difficulties caused by particles.展开更多
We prove the local in time existence and a blow up criterion of solution in the Holder spaces for the inviscid Boussinesq system in RN,N ≥ 2, under the assumptions that the initial values θo,uo ∈ Cr, with 1 〈 r ≠ 2.
This paper undertakes a systematic treatment of the low regularity local well-posedness and ill-posedness theory in H3 and Hs for semilinear wave equations with polynomial nonlinearity in u and (?)u. This ill-posed re...This paper undertakes a systematic treatment of the low regularity local well-posedness and ill-posedness theory in H3 and Hs for semilinear wave equations with polynomial nonlinearity in u and (?)u. This ill-posed result concerns the focusing type equations with nonlinearity on u and (?)tu.展开更多
In this paper we prove the local well-posedness of strong solutions to the compressible nematic liquid crystals flow with vacuum in a bounded domainΩ■R3.
In this paper, we prove the local existence, uniqueness and stability of a supersonic shock for the supersonic isothermal incoming flow past a curved cone. Major difficulties include constructing an appropriate soluti...In this paper, we prove the local existence, uniqueness and stability of a supersonic shock for the supersonic isothermal incoming flow past a curved cone. Major difficulties include constructing an appropriate solution and treatincg the Neumann boundary conditions and local stability condition.展开更多
Let X be a complex Banach space and let B and C be two closed linear operators on X satisfying the condition D(B)?D(C),and let d∈L^(1)(R_(+))and 0≤β<α≤2.We characterize the well-posedness of the fractional int...Let X be a complex Banach space and let B and C be two closed linear operators on X satisfying the condition D(B)?D(C),and let d∈L^(1)(R_(+))and 0≤β<α≤2.We characterize the well-posedness of the fractional integro-differential equations D^(α)u(t)+CD^(β)u(t)=Bu(t)+∫_(-∞)td(t-s)Bu(s)ds+f(t),(0≤t≤2π)on periodic Lebesgue-Bochner spaces L^(p)(T;X)and periodic Besov spaces B_(p,q)^(s)(T;X).展开更多
In this paper, we consider the initial value problem for the incompressible generalized Phan-Thien-Tanner(GPTT) model. This model pertains to the dynamic properties of polymeric fluids. Under appropriate assumptions o...In this paper, we consider the initial value problem for the incompressible generalized Phan-Thien-Tanner(GPTT) model. This model pertains to the dynamic properties of polymeric fluids. Under appropriate assumptions on smooth function f, we find a particular solution to the GPTT model. In dimension three, we establish the global existence and the optimal time decay rates of strong solutions provided that the initial data is close to the particular solution. The results which are presented here are generalizations of the network viscoelastic models.展开更多
We consider the fourth-order nonlinear Schr?dinger equation(4NLS)(i?t+εΔ+Δ2)u=c1um+c2(?u)um-1+c3(?u)2um-2,and establish the conditional almost sure global well-posedness for random initial data in Hs(Rd)for s∈(sc-...We consider the fourth-order nonlinear Schr?dinger equation(4NLS)(i?t+εΔ+Δ2)u=c1um+c2(?u)um-1+c3(?u)2um-2,and establish the conditional almost sure global well-posedness for random initial data in Hs(Rd)for s∈(sc-1/2,sc],when d≥3 and m≥5,where sc:=d/2-2/(m-1)is the scaling critical regularity of 4NLS with the second order derivative nonlinearities.Our proof relies on the nonlinear estimates in a new M-norm and the stability theory in the probabilistic setting.Similar supercritical global well-posedness results also hold for d=2,m≥4 and d≥3,3≤m<5.展开更多
Background Copy number variants(CNV)hold significant functional and evolutionary importance.Numerous ongoing CNV studies aim to elucidate the etiology of human diseases and gain insights into the population structure ...Background Copy number variants(CNV)hold significant functional and evolutionary importance.Numerous ongoing CNV studies aim to elucidate the etiology of human diseases and gain insights into the population structure of livestock.High-density chips have enabled the detection of CNV with increased resolution,leading to the identification of even small CNV.This study aimed to identify CNV in local Italian chicken breeds and investigate their distribution across the genome.Results Copy number variants were mainly distributed across the first six chromosomes and primarily associated with loss type CNV.The majority of CNV in the investigated breeds were of types 0 and 1,and the minimum length of CNV was significantly larger than that reported in previous studies.Interestingly,a high proportion of the length of chromosome 16 was covered by copy number variation regions(CNVR),with the major histocompatibility complex being the likely cause.Among the genes identified within CNVR,only those present in at least five animals across breeds(n=95)were discussed to reduce the focus on redundant CNV.Some of these genes have been associated to functional traits in chickens.Notably,several CNVR on different chromosomes harbor genes related to muscle development,tissue-specific biological processes,heat stress resistance,and immune response.Quantitative trait loci(QTL)were also analyzed to investigate potential overlapping with the identified CNVR:54 out of the 95 gene-containing regions overlapped with 428 QTL associated to body weight and size,carcass characteristics,egg production,egg components,fat deposition,and feed intake.Conclusions The genomic phenomena reported in this study that can cause changes in the distribution of CNV within the genome over time and the comparison of these differences in CNVR of the local chicken breeds could help in preserving these genetic resources.展开更多
Four major studies(Checkmate577,Keynote-590,Checkmate649 and Attraction-4)of locally advanced esophageal cancer published in 2020 have established the importance of immunotherapy,represented by anti-programmed death p...Four major studies(Checkmate577,Keynote-590,Checkmate649 and Attraction-4)of locally advanced esophageal cancer published in 2020 have established the importance of immunotherapy,represented by anti-programmed death protein(PD)-1 in postoperative adjuvant treatment and advanced first-line treatment of locally advanced or advanced esophageal cancer and esophagogastric junction cancer,from the aspects of proof of concept,long-term survival,overall survival rate and progression-free survival.For unresectable or inoperable nonmetastatic esophageal cancer,concurrent radiotherapy and chemotherapy is the standard treatment recommended by various guidelines.Because its curative effect is still not ideal,it is necessary to explore radical radiotherapy and chemotherapy in the future,and it is considered to be promising to combine them with immunotherapeutic drugs such as anti-PD-1.This paper mainly discusses how to combine radical concurrent radiotherapy and chemotherapy with immunotherapy for unresectable local advanced esophageal cancer.展开更多
Early screening of diabetes retinopathy(DR)plays an important role in preventing irreversible blindness.Existing research has failed to fully explore effective DR lesion information in fundus maps.Besides,traditional ...Early screening of diabetes retinopathy(DR)plays an important role in preventing irreversible blindness.Existing research has failed to fully explore effective DR lesion information in fundus maps.Besides,traditional attention schemes have not considered the impact of lesion type differences on grading,resulting in unreasonable extraction of important lesion features.Therefore,this paper proposes a DR diagnosis scheme that integrates a multi-level patch attention generator(MPAG)and a lesion localization module(LLM).Firstly,MPAGis used to predict patches of different sizes and generate a weighted attention map based on the prediction score and the types of lesions contained in the patches,fully considering the impact of lesion type differences on grading,solving the problem that the attention maps of lesions cannot be further refined and then adapted to the final DR diagnosis task.Secondly,the LLM generates a global attention map based on localization.Finally,the weighted attention map and global attention map are weighted with the fundus map to fully explore effective DR lesion information and increase the attention of the classification network to lesion details.This paper demonstrates the effectiveness of the proposed method through extensive experiments on the public DDR dataset,obtaining an accuracy of 0.8064.展开更多
The subthalamic nucleus(STN)is considered the best target for deep brain stimulation treatments of Parkinson’s disease(PD).It is difficult to localize the STN due to its small size and deep location.Multichannel micr...The subthalamic nucleus(STN)is considered the best target for deep brain stimulation treatments of Parkinson’s disease(PD).It is difficult to localize the STN due to its small size and deep location.Multichannel microelectrode arrays(MEAs)can rapidly and precisely locate the STN,which is important for precise stimulation.In this paper,16-channel MEAs modified with multiwalled carbon nanotube/poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate)(MWCNT/PEDOT:PSS)nanocomposites were designed and fabricated,and the accurate and rapid identification of the STN in PD rats was performed using detection sites distributed at different brain depths.These results showed that nuclei in 6-hydroxydopamine hydrobromide(6-OHDA)-lesioned brains discharged more intensely than those in unlesioned brains.In addition,the MEA simultaneously acquired neural signals from both the STN and the upper or lower boundary nuclei of the STN.Moreover,higher values of spike firing rate,spike amplitude,local field potential(LFP)power,and beta oscillations were detected in the STN of the 6-OHDA-lesioned brain,and may therefore be biomarkers of STN localization.Compared with the STNs of unlesioned brains,the power spectral density of spikes and LFPs synchronously decreased in the delta band and increased in the beta band of 6-OHDA-lesioned brains.This may be a cause of sleep and motor disorders associated with PD.Overall,this work describes a new cellular-level localization and detection method and provides a tool for future studies of deep brain nuclei.展开更多
The flow field near a spur dike such as down flow and horseshoe vortex system(HVS)are susceptible to the topographic changes in the local scouring process,resulting in variation of the sediment transport with time.In ...The flow field near a spur dike such as down flow and horseshoe vortex system(HVS)are susceptible to the topographic changes in the local scouring process,resulting in variation of the sediment transport with time.In this study,large eddy simulations with fixed-bed at different scouring stages were conducted to investigate the changes in flow field.The results imply that the bed deformation leads to an increase in flow rate per unit area,which represent the capability of sediment transportation by water,in the scour hole.Moreover,the intensity of turbulent kinetic energy and bimodal motion near the sand bed induced by the HVS were also varied.However,the peak moments between the two sediment transport mechanisms were different.Hence,understanding the complex feedback mechanism between topography and flow field is essential for the local scour problem.展开更多
Due to their high reliability and cost-efficiency,submarine pipelines are widely used in offshore oil and gas resource engineering.Due to the interaction of waves,currents,seabed,and pipeline structures,the soil aroun...Due to their high reliability and cost-efficiency,submarine pipelines are widely used in offshore oil and gas resource engineering.Due to the interaction of waves,currents,seabed,and pipeline structures,the soil around submarine pipelines is prone to local scour,severely affecting their operational safety.With the Yellow River Delta as the research area and based on the renormalized group(RNG)k-εturbulence model and Stokes fifth-order wave theory,this study solves the Navier-Stokes(N-S)equation using the finite difference method.The volume of fluid(VOF)method is used to describe the fluid-free surface,and a threedimensional numerical model of currents and waves-submarine pipeline-silty sandy seabed is established.The rationality of the numerical model is verified using a self-built waveflow flume.On this basis,in this study,the local scour development and characteristics of submarine pipelines in the Yellow River Delta silty sandy seabed in the prototype environment are explored and the influence of the presence of pipelines on hydrodynamic features such as surrounding flow field,shear stress,and turbulence intensity is analyzed.The results indicate that(1)local scour around submarine pipelines can be divided into three stages:rapid scour,slow scour,and stable scour.The maximum scour depth occurs directly below the pipeline,and the shape of the scour pits is asymmetric.(2)As the water depth decreases and the pipeline suspension height increases,the scour becomes more intense.(3)When currents go through a pipeline,a clear stagnation point is formed in front of the pipeline,and the flow velocity is positively correlated with the depth of scour.This study can provide a valuable reference for the protection of submarine pipelines in this area.展开更多
Dose-dense chemotherapy is the preferred first-line therapy for triple-negative breast cancer(TNBC),a highly aggressive disease with a poor prognosis.This treatment uses the same drug doses as conventional chemotherap...Dose-dense chemotherapy is the preferred first-line therapy for triple-negative breast cancer(TNBC),a highly aggressive disease with a poor prognosis.This treatment uses the same drug doses as conventional chemotherapy but with shorter dosing intervals,allowing for promising clinical outcomes with intensive treatment.However,the frequent systemic administration used for this treatment results in systemic toxicity and low patient compliance,limiting therapeutic efficacy and clinical benefit.Here,we report local dose-dense chemotherapy to treat TNBC by implanting 3D printed devices with timeprogrammed pulsatile release profiles.The implantable device can control the time between drug releases based on its internal microstructure design,which can be used to control dose density.The device is made of biodegradable materials for clinical convenience and designed for minimally invasive implantation via a trocar.Dose density variation of local chemotherapy using programmable release enhances anti-cancer effects in vitro and in vivo.Under the same dose density conditions,device-based chemotherapy shows a higher anticancer effect and less toxic response than intratumoral injection.We demonstrate local chemotherapy utilizing the implantable device that simulates the drug dose,number of releases,and treatment duration of the dose-dense AC(doxorubicin and cyclophosphamide)regimen preferred for TNBC treatment.Dose density modulation inhibits tumor growth,metastasis,and the expression of drug resistance-related proteins,including p-glycoprotein and breast cancer resistance protein.To the best of our knowledge,local dose-dense chemotherapy has not been reported,and our strategy can be expected to be utilized as a novel alternative to conventional therapies and improve anti-cancer efficiency.展开更多
To improve the anti-jamming and interference mitigation ability of the UAV-aided communication systems, this paper investigates the channel selection optimization problem in face of both internal mutual interference a...To improve the anti-jamming and interference mitigation ability of the UAV-aided communication systems, this paper investigates the channel selection optimization problem in face of both internal mutual interference and external malicious jamming. A cooperative anti-jamming and interference mitigation method based on local altruistic is proposed to optimize UAVs’ channel selection. Specifically, a Stackelberg game is modeled to formulate the confrontation relationship between UAVs and the jammer. A local altruistic game is modeled with each UAV considering the utilities of both itself and other UAVs. A distributed cooperative anti-jamming and interference mitigation algorithm is proposed to obtain the Stackelberg equilibrium. Finally, the convergence of the proposed algorithm and the impact of the transmission power on the system loss value are analyzed, and the anti-jamming performance of the proposed algorithm can be improved by around 64% compared with the existing algorithms.展开更多
In this note we derive MHD boundary layer equations according to viscosity and resistivity coefficients. Especially, when these viscosity and resistivity coefficients are of different orders, it leads to degenerate MH...In this note we derive MHD boundary layer equations according to viscosity and resistivity coefficients. Especially, when these viscosity and resistivity coefficients are of different orders, it leads to degenerate MHD boundary layer equations. We prove these degenerate boundary layers are stable around a steady solution.展开更多
基金supported by NSFC(11971234)supported in part by NSFC(11671193)A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions。
文摘In this paper we prove the local well-posedness of strong solutions to a chemotaxisshallow water system with initial vacuum in a bounded domainΩ■R^(2)without the standard compatibility condition for the initial data.This improves some results obtained in[J.Differential Equations 261(2016),6758-6789].
基金supported by the National Natural Science Foundation of China(11171266)
文摘This paper is concerned with the Cauchy problem of a seventh order dispersive equation. We prove local well-posedness with initial data in Sobolev spaces Hs（R） for negative indices of s〉-114 .
基金This work was supported by Natural Science Foundation of China(11871412).
文摘This article is concerned with the 3 D nonhomogeneous incompressible magnetohydrodynamics equations with a slip boundary conditions in bounded domain.We obtain weighted estimates of the velocity and magnetic field,and address the issue of local existence and uniqueness of strong solutions with the weaker initial data which contains vacuum states.
基金supported by the National Natural Science Foundation of China(12101095)the Natural Science Foundation of Chongqing(CSTB2022NSCQ-MSX0949,2022NSCQ-MSX2878,CSTC2021jcyj-msxmX0224)+2 种基金the Science and Technology Research Program of Chongqing Municipal Education Commission(KJQN202100517,KJQN202300542,KJQN202100511)the Research Project of Chongqing Education Commission(CXQT21014)the grant of Chongqing Young Experts’Workshop.
文摘In this paper,we consider a model of compressible isentropic two-fluid magneto-hydrodynamics without resistivity in a strip domain in three dimensional space.By exploiting the two-tier energy method developed in[Anal PDE,2013,6:1429–1533],we prove the global well-posedness of the governing model around a uniform magnetic field which is non-parallel to the horizontal boundary.Moreover,we show that the solution converges to the steady state at an almost exponential rate as time goes to infinity.Compared to the work of Tan and Wang[SIAM J Math Anal,2018,50:1432–1470],we need to overcome the difficulties caused by particles.
文摘We prove the local in time existence and a blow up criterion of solution in the Holder spaces for the inviscid Boussinesq system in RN,N ≥ 2, under the assumptions that the initial values θo,uo ∈ Cr, with 1 〈 r ≠ 2.
基金Project supported by the National Natural Science Foundation of China (No.10271108).
文摘This paper undertakes a systematic treatment of the low regularity local well-posedness and ill-posedness theory in H3 and Hs for semilinear wave equations with polynomial nonlinearity in u and (?)u. This ill-posed result concerns the focusing type equations with nonlinearity on u and (?)tu.
基金Fan is supported by NSFC(Grant No.11971234).Li is supported by NSFC(Grant No.11671193)and A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions.
文摘In this paper we prove the local well-posedness of strong solutions to the compressible nematic liquid crystals flow with vacuum in a bounded domainΩ■R3.
基金supported by Scientific Research Fund of Nanjing Institute of Technology (Grant No.YKJ201339)National Natural Science Foundation of China (Grant Nos.11371189 and 11101190)the Priority Academic Program Development of Jiangsu Higher Education Institutions
文摘In this paper, we prove the local existence, uniqueness and stability of a supersonic shock for the supersonic isothermal incoming flow past a curved cone. Major difficulties include constructing an appropriate solution and treatincg the Neumann boundary conditions and local stability condition.
基金the NSF of China(12171266,12171062)the NSF of Chongqing(CSTB2022NSCQ-JQX0004)。
文摘Let X be a complex Banach space and let B and C be two closed linear operators on X satisfying the condition D(B)?D(C),and let d∈L^(1)(R_(+))and 0≤β<α≤2.We characterize the well-posedness of the fractional integro-differential equations D^(α)u(t)+CD^(β)u(t)=Bu(t)+∫_(-∞)td(t-s)Bu(s)ds+f(t),(0≤t≤2π)on periodic Lebesgue-Bochner spaces L^(p)(T;X)and periodic Besov spaces B_(p,q)^(s)(T;X).
基金Yuhui Chen was supported by the NNSF of China(12201655)Qinghe Yao was supported by the NNSF of China (11972384)+2 种基金the Guangdong Science and Technology Fund (2021B1515310001)Zheng-an Yao was supported by the NNSF of China (11971496)the National Key R&D Program of China (2020YFA0712500)。
文摘In this paper, we consider the initial value problem for the incompressible generalized Phan-Thien-Tanner(GPTT) model. This model pertains to the dynamic properties of polymeric fluids. Under appropriate assumptions on smooth function f, we find a particular solution to the GPTT model. In dimension three, we establish the global existence and the optimal time decay rates of strong solutions provided that the initial data is close to the particular solution. The results which are presented here are generalizations of the network viscoelastic models.
基金supported by the NationalNatural Science Foundation of China(12001236)the Natural Science Foundation of Guangdong Province(2020A1515110494)。
文摘We consider the fourth-order nonlinear Schr?dinger equation(4NLS)(i?t+εΔ+Δ2)u=c1um+c2(?u)um-1+c3(?u)2um-2,and establish the conditional almost sure global well-posedness for random initial data in Hs(Rd)for s∈(sc-1/2,sc],when d≥3 and m≥5,where sc:=d/2-2/(m-1)is the scaling critical regularity of 4NLS with the second order derivative nonlinearities.Our proof relies on the nonlinear estimates in a new M-norm and the stability theory in the probabilistic setting.Similar supercritical global well-posedness results also hold for d=2,m≥4 and d≥3,3≤m<5.
基金supported by the project“Protection of biodiversity of Italian poultry breeds—TuBAvI”,funded in the framework of the PSRN 2014–2020,submeasure 10.2“Support for sustainable conservation,use and development of genetic resources in agriculture”.
文摘Background Copy number variants(CNV)hold significant functional and evolutionary importance.Numerous ongoing CNV studies aim to elucidate the etiology of human diseases and gain insights into the population structure of livestock.High-density chips have enabled the detection of CNV with increased resolution,leading to the identification of even small CNV.This study aimed to identify CNV in local Italian chicken breeds and investigate their distribution across the genome.Results Copy number variants were mainly distributed across the first six chromosomes and primarily associated with loss type CNV.The majority of CNV in the investigated breeds were of types 0 and 1,and the minimum length of CNV was significantly larger than that reported in previous studies.Interestingly,a high proportion of the length of chromosome 16 was covered by copy number variation regions(CNVR),with the major histocompatibility complex being the likely cause.Among the genes identified within CNVR,only those present in at least five animals across breeds(n=95)were discussed to reduce the focus on redundant CNV.Some of these genes have been associated to functional traits in chickens.Notably,several CNVR on different chromosomes harbor genes related to muscle development,tissue-specific biological processes,heat stress resistance,and immune response.Quantitative trait loci(QTL)were also analyzed to investigate potential overlapping with the identified CNVR:54 out of the 95 gene-containing regions overlapped with 428 QTL associated to body weight and size,carcass characteristics,egg production,egg components,fat deposition,and feed intake.Conclusions The genomic phenomena reported in this study that can cause changes in the distribution of CNV within the genome over time and the comparison of these differences in CNVR of the local chicken breeds could help in preserving these genetic resources.
基金Supported by Natural Science Foundation of Fujian Province,No.2021J011259.
文摘Four major studies(Checkmate577,Keynote-590,Checkmate649 and Attraction-4)of locally advanced esophageal cancer published in 2020 have established the importance of immunotherapy,represented by anti-programmed death protein(PD)-1 in postoperative adjuvant treatment and advanced first-line treatment of locally advanced or advanced esophageal cancer and esophagogastric junction cancer,from the aspects of proof of concept,long-term survival,overall survival rate and progression-free survival.For unresectable or inoperable nonmetastatic esophageal cancer,concurrent radiotherapy and chemotherapy is the standard treatment recommended by various guidelines.Because its curative effect is still not ideal,it is necessary to explore radical radiotherapy and chemotherapy in the future,and it is considered to be promising to combine them with immunotherapeutic drugs such as anti-PD-1.This paper mainly discusses how to combine radical concurrent radiotherapy and chemotherapy with immunotherapy for unresectable local advanced esophageal cancer.
基金supported in part by the Research on the Application of Multimodal Artificial Intelligence in Diagnosis and Treatment of Type 2 Diabetes under Grant No.2020SK50910in part by the Hunan Provincial Natural Science Foundation of China under Grant 2023JJ60020.
文摘Early screening of diabetes retinopathy(DR)plays an important role in preventing irreversible blindness.Existing research has failed to fully explore effective DR lesion information in fundus maps.Besides,traditional attention schemes have not considered the impact of lesion type differences on grading,resulting in unreasonable extraction of important lesion features.Therefore,this paper proposes a DR diagnosis scheme that integrates a multi-level patch attention generator(MPAG)and a lesion localization module(LLM).Firstly,MPAGis used to predict patches of different sizes and generate a weighted attention map based on the prediction score and the types of lesions contained in the patches,fully considering the impact of lesion type differences on grading,solving the problem that the attention maps of lesions cannot be further refined and then adapted to the final DR diagnosis task.Secondly,the LLM generates a global attention map based on localization.Finally,the weighted attention map and global attention map are weighted with the fundus map to fully explore effective DR lesion information and increase the attention of the classification network to lesion details.This paper demonstrates the effectiveness of the proposed method through extensive experiments on the public DDR dataset,obtaining an accuracy of 0.8064.
基金funded by the National Natural Science Foundation of China(Nos.L2224042,T2293731,62121003,61960206012,61973292,62171434,61975206,and 61971400)the Frontier Interdisciplinary Project of the Chinese Academy of Sciences(No.XK2022XXC003)+2 种基金the National Key Research and Development Program of China(Nos.2022YFC2402501 and 2022YFB3205602)the Major Program of Scientific and Technical Innovation 2030(No.2021ZD02016030)the Scientific Instrument Developing Project of he Chinese Academy of Sciences(No.GJJSTD20210004).
文摘The subthalamic nucleus(STN)is considered the best target for deep brain stimulation treatments of Parkinson’s disease(PD).It is difficult to localize the STN due to its small size and deep location.Multichannel microelectrode arrays(MEAs)can rapidly and precisely locate the STN,which is important for precise stimulation.In this paper,16-channel MEAs modified with multiwalled carbon nanotube/poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate)(MWCNT/PEDOT:PSS)nanocomposites were designed and fabricated,and the accurate and rapid identification of the STN in PD rats was performed using detection sites distributed at different brain depths.These results showed that nuclei in 6-hydroxydopamine hydrobromide(6-OHDA)-lesioned brains discharged more intensely than those in unlesioned brains.In addition,the MEA simultaneously acquired neural signals from both the STN and the upper or lower boundary nuclei of the STN.Moreover,higher values of spike firing rate,spike amplitude,local field potential(LFP)power,and beta oscillations were detected in the STN of the 6-OHDA-lesioned brain,and may therefore be biomarkers of STN localization.Compared with the STNs of unlesioned brains,the power spectral density of spikes and LFPs synchronously decreased in the delta band and increased in the beta band of 6-OHDA-lesioned brains.This may be a cause of sleep and motor disorders associated with PD.Overall,this work describes a new cellular-level localization and detection method and provides a tool for future studies of deep brain nuclei.
基金supported by Shenzhen Science and Technology Program(Grant No.JCYJ20220818102012024)Hong Kong Research Grants Council(Grant Nos.T21–602/16-R and RGC R5037–18)。
文摘The flow field near a spur dike such as down flow and horseshoe vortex system(HVS)are susceptible to the topographic changes in the local scouring process,resulting in variation of the sediment transport with time.In this study,large eddy simulations with fixed-bed at different scouring stages were conducted to investigate the changes in flow field.The results imply that the bed deformation leads to an increase in flow rate per unit area,which represent the capability of sediment transportation by water,in the scour hole.Moreover,the intensity of turbulent kinetic energy and bimodal motion near the sand bed induced by the HVS were also varied.However,the peak moments between the two sediment transport mechanisms were different.Hence,understanding the complex feedback mechanism between topography and flow field is essential for the local scour problem.
基金China Postdoctoral Science Foundation,Grant/Award Number:2023M731999National Natural Science Foundation of China,Grant/Award Number:52301326。
文摘Due to their high reliability and cost-efficiency,submarine pipelines are widely used in offshore oil and gas resource engineering.Due to the interaction of waves,currents,seabed,and pipeline structures,the soil around submarine pipelines is prone to local scour,severely affecting their operational safety.With the Yellow River Delta as the research area and based on the renormalized group(RNG)k-εturbulence model and Stokes fifth-order wave theory,this study solves the Navier-Stokes(N-S)equation using the finite difference method.The volume of fluid(VOF)method is used to describe the fluid-free surface,and a threedimensional numerical model of currents and waves-submarine pipeline-silty sandy seabed is established.The rationality of the numerical model is verified using a self-built waveflow flume.On this basis,in this study,the local scour development and characteristics of submarine pipelines in the Yellow River Delta silty sandy seabed in the prototype environment are explored and the influence of the presence of pipelines on hydrodynamic features such as surrounding flow field,shear stress,and turbulence intensity is analyzed.The results indicate that(1)local scour around submarine pipelines can be divided into three stages:rapid scour,slow scour,and stable scour.The maximum scour depth occurs directly below the pipeline,and the shape of the scour pits is asymmetric.(2)As the water depth decreases and the pipeline suspension height increases,the scour becomes more intense.(3)When currents go through a pipeline,a clear stagnation point is formed in front of the pipeline,and the flow velocity is positively correlated with the depth of scour.This study can provide a valuable reference for the protection of submarine pipelines in this area.
基金supported by the National Research Foundation of Korea(NRF)grant funded by the Ministry of Science and ICT(MSIT)(No.2021R1A2C2012808)Technology Innovation Program(Alchemist Project)(No.20012378)funded by the Ministry of Trade,Industry&Energy(MOTIE),South Korea.
文摘Dose-dense chemotherapy is the preferred first-line therapy for triple-negative breast cancer(TNBC),a highly aggressive disease with a poor prognosis.This treatment uses the same drug doses as conventional chemotherapy but with shorter dosing intervals,allowing for promising clinical outcomes with intensive treatment.However,the frequent systemic administration used for this treatment results in systemic toxicity and low patient compliance,limiting therapeutic efficacy and clinical benefit.Here,we report local dose-dense chemotherapy to treat TNBC by implanting 3D printed devices with timeprogrammed pulsatile release profiles.The implantable device can control the time between drug releases based on its internal microstructure design,which can be used to control dose density.The device is made of biodegradable materials for clinical convenience and designed for minimally invasive implantation via a trocar.Dose density variation of local chemotherapy using programmable release enhances anti-cancer effects in vitro and in vivo.Under the same dose density conditions,device-based chemotherapy shows a higher anticancer effect and less toxic response than intratumoral injection.We demonstrate local chemotherapy utilizing the implantable device that simulates the drug dose,number of releases,and treatment duration of the dose-dense AC(doxorubicin and cyclophosphamide)regimen preferred for TNBC treatment.Dose density modulation inhibits tumor growth,metastasis,and the expression of drug resistance-related proteins,including p-glycoprotein and breast cancer resistance protein.To the best of our knowledge,local dose-dense chemotherapy has not been reported,and our strategy can be expected to be utilized as a novel alternative to conventional therapies and improve anti-cancer efficiency.
基金supported in part by the National Natural Science Foundation of China (No.62271253,61901523,62001381)Fundamental Research Funds for the Central Universities (No.NS2023018)+2 种基金the National Aerospace Science Foundation of China under Grant 2023Z021052002the open research fund of National Mobile Communications Research Laboratory,Southeast University (No.2023D09)Postgraduate Research & Practice Innovation Program of NUAA (No.xcxjh20220402)。
文摘To improve the anti-jamming and interference mitigation ability of the UAV-aided communication systems, this paper investigates the channel selection optimization problem in face of both internal mutual interference and external malicious jamming. A cooperative anti-jamming and interference mitigation method based on local altruistic is proposed to optimize UAVs’ channel selection. Specifically, a Stackelberg game is modeled to formulate the confrontation relationship between UAVs and the jammer. A local altruistic game is modeled with each UAV considering the utilities of both itself and other UAVs. A distributed cooperative anti-jamming and interference mitigation algorithm is proposed to obtain the Stackelberg equilibrium. Finally, the convergence of the proposed algorithm and the impact of the transmission power on the system loss value are analyzed, and the anti-jamming performance of the proposed algorithm can be improved by around 64% compared with the existing algorithms.
文摘In this note we derive MHD boundary layer equations according to viscosity and resistivity coefficients. Especially, when these viscosity and resistivity coefficients are of different orders, it leads to degenerate MHD boundary layer equations. We prove these degenerate boundary layers are stable around a steady solution.
