Objective: To investigate the effects of Yanghe Pingchuan Granules on airway remodeling in asthmatic rats, and to explore the mechanism of Interleukin-6/Janus kinase 2/ Signal transducing activator of transcription 3(...Objective: To investigate the effects of Yanghe Pingchuan Granules on airway remodeling in asthmatic rats, and to explore the mechanism of Interleukin-6/Janus kinase 2/ Signal transducing activator of transcription 3(IL-6/JAK2/STAT3) signal axis. Methods: We separated 42 healthy male SD rats into two groups, a control group (7) and a model group (35).The model group was sensitized with a combination of ovalbumin (OVA) and aluminum hydroxide for 2 weeks, while the control group was given an equal amount of physiological saline.After 2 weeks, the modeling group was randomly divided into Model group, Yanghe Pingchuan Granules high, medium and low dose groups and Dexamethasone group, each group consisted of 7 animals. After 4 weeks, OVA atomization and gavage were used for stimulation and treatment. Yanghe Pingchuan Granules high, middle and low groups were given 15.48, 7.74, 3.87 g∙kg-1 Yanghe Pingchuan Granules daily, dexamethasone group was given 0.0625 mg∙kg-1 dexamethasone daily, and the other groups were given the same amount of normal saline. HE, PAS and Masson staining were used to observe the lung histopathological changes in rats. The levels of interleukin-6, IL-23 and IL-17A were detected by ELISA. The expression levels of JAK-2, P-JAK2, STAT3 and P-STAT3 in lung tissues were detected by Western blot. Real-time quantitative polymerase chain reaction (qRT-PCR) was used to detect the mRNA expression levels of IL-6, JAK2 and STAT3 in rat lung tissue. Results: The lung tissue structure of the model group was severely damaged compared to the control group, accompanied by a great many of inflammatory cell infiltration, goblet cell hyperplasia, subepithelial collagen fiber deposition and airway epithelial thickening were more obvious. The expressions of IL-6, IL- 23 and IL-17A in serum were significantly increased (P<0.01), the protein expression levels of JAK-2, P-JAK2, STAT3 and P-STAT3 and the mRNA expression levels of IL-6, JAK2 and STAT3 in lung tissue were significantly increased (P<0.01);Compared with the model group, inflammatory cell infiltration, goblet cell proliferation, subepithelial collagen fiber deposition and airway epithelial thickening were significantly reduced in each administration group, and the expressions of IL-6, IL-23 and IL-17A in serum were significantly decreased (P< 0.01). The protein expression levels of JAK-2, P-JAK2, STAT3 and P-STAT3 and mRNA expression levels of IL-6, JAK2 and STAT3 in lung tissue were significantly decreased (P<0.01). Conclusion: Yanghe Pingchuan Granules can significantly alleviate airway remodeling in asthmatic rats, and its mechanism may be through inhibiting the IL-6/JAK2/STAT3 signal axis.展开更多
A three dimensional(3D)numerical wave flume is used to investigate carefully the ISWs(Internal solitary wave)forces acting on cylinders interacting with a stratified shear environment.Using the Large-Eddy Simulation(L...A three dimensional(3D)numerical wave flume is used to investigate carefully the ISWs(Internal solitary wave)forces acting on cylinders interacting with a stratified shear environment.Using the Large-Eddy Simulation(LES)approach and analyzing the distribution of shear stress and pressure along the surface of the cylinder,the differential pressure resistance and the viscous force are obtained.The method of multiple linear regression analysis is adopted and a comprehensive influence coefficient is determined accordingly to account for the dimensionless forces acting on the cylinder.Results show that the differential pressure resistance on a square cylinder is 1.5 times higher than that on a circular cylinder in the upper layer,while the differential pressure resistance on a square cylinder is 3.5 times larger than that on a circular cylinder in the lower layer.The viscous force is 1–2 orders of magnitude smaller than the differential pressure resistance,which means that the viscous force could be ignored.The comprehensive influence coefficient shows positive correlation with the relative wave height and negative correlation with upper and lower water depth ratio.展开更多
<b>Objective:</b> The objective is to investigate whether acupuncture can protect brain by regulating the expression of ICAM-5 mRNA in brain tissue. <b>Methods:</b> Male SD rats were used to co...<b>Objective:</b> The objective is to investigate whether acupuncture can protect brain by regulating the expression of ICAM-5 mRNA in brain tissue. <b>Methods:</b> Male SD rats were used to construct a middle cerebral artery occlusion reperfusion injury (Middle cerebral artery occlusion, MCAO) model, and the rats were randomly divided into 4 groups, namely the normal group (group A) and the sham operation group (group B), MCAO group (group C), MCAO + acupuncture group (group D);real-time fluorescent quantitative PCR (RT-qPCR) was used to detect the expression of ICAM-5 mRNA in the brain tissue of the ischemic area, and HE staining and TUNEL were used to detect the level of neuronal apoptosis to evaluate the therapeutic effect. <b>Results:</b> Acupuncture can improve neuronal morphology and reduce neuronal apoptosis in rats with ischemic stroke. RT-qPCR: compared with group A and group B, the expression level of ICAM-5 mRNA in the brain tissues of group C and group D decreased, while compared with group C, The expression of ICAM-5 mRNA in the brain tissue of group D was significantly up-regulated (P < 0.05). There was no statistical difference between group A and group B (P > 0.05). <b>Conclusion:</b> The effectiveness of acupuncture in the treatment of ischemic stroke may achieve neuroprotection by up-regulating the expression level of ICAM-5 mRNA.展开更多
[Objectives]To screen out the main effective components of Wulan Shisanwei Decoction in the treatment of hypertension complicated with hyperlipidemia based on the method of network pharmacology,predict the target and ...[Objectives]To screen out the main effective components of Wulan Shisanwei Decoction in the treatment of hypertension complicated with hyperlipidemia based on the method of network pharmacology,predict the target and explore the possible mechanism.[Methods]13 components of Wulan Shisanwei Decoction were searched on the TCMSP data platform,the corresponding active components were found and the corresponding targets were searched in Pubchem database.GeneCards database was used to screen the corresponding targets of hypertension and hyperlipidemia.The core target PPI network of Wulan Shisanwei Decoction in the treatment of hypertension complicated with hyperlipidemia was constructed by processing in STRING database.The effective data were imported into Cytoscape 3.8.0 to analyze the network topology parameters,and they were screened according to the degree value greater than the average value.Finally,the relevant information about the core target of Wulan Shisanwei Decoction in the treatment of hypertension complicated with hyperlipidemia was obtained.GO enrichment analysis and KEGG pathway analysis were carried out for core targets in DAVID database.The visualization map of"drug-component-target-disease"was drawn by Cytoscape 3.8.0.[Results]A total of 85 active components were obtained from Wulan Shisanwei Decoction,and there were 1532 corresponding targets.A total of 303 key targets were obtained by intersecting corresponding drug targets with disease targets.3178 biological processes were obtained by GO analysis(P<0.05)and 192 signaling pathways were obtained by KEGG enrichment analysis(P<0.05).[Conclusions]It was predicted that the main active components of Wulan Shisanwei Decoction in the treatment of hypertension complicated with hyperlipidemia were stigmasterol,acacetin,pectolinarigenin,isorhamnetin,alizarin,quercetin,nordamnacanthal,kaempferol,luteolin,glyceollin,kushenol,t,3-methylkempferol,ellagic acid,etc.20 core targets were selected in the treatment of hypertension complicated with hyperlipidemia:SRC,STAT3,HSP90AA1,MAPK1,MAPK3,PIK3R1,HRAS,GRB2,PIK3CA,AKT1,PTPN11,ESR1,LCK,EGFR,FYN,EP300,RELA,JUN,LYN,RHOA.These targets were involved in PI3K-Akt signaling pathway,lipid and atherosclerosis,proteoglycan in cancer,Ras signaling pathway,etc.to exert a response to oxidative stress,cellular response to chemical stress,peptidyl-tyrosine phosphorylation and peptide tyrosine modification,and can intervene in the early stage of the disease.It may be the potential mechanism of Wulan Shisanwei Decoction in the treatment of hypertension complicated with hyperlipidemia.展开更多
Scanning tunneling microscopy (STM ) has been first employed to study the surface relief accompanying bainite transformation in a Fe-2.17C-12.18Cr-0.31Si-0.26Mn (wt pct) steel. With the exclusive vertical resolution o...Scanning tunneling microscopy (STM ) has been first employed to study the surface relief accompanying bainite transformation in a Fe-2.17C-12.18Cr-0.31Si-0.26Mn (wt pct) steel. With the exclusive vertical resolution of STM, we observed that the surface relief associated with bainite is a group of surface reliefs related to subplates, subunits and sub-subunits. As a whole, the relief group is in a tent shape, not of invariant plane strain (IPS) type, which is obviously different from that of martensite, and implying that bainite is not formed by shear mechanism. The fine structure of bainite in Fe-1.0C-4Cr-2.0Si (wt pct) alloy has also been studied with STM and TEM. It is found that the bainite plate is composed of subplates, subunits and sub-subunits. On the basis of the fine structure inside a bainitic ferrite plate observed under STM, a sympathetic-ledgewise mechanism of bainite formation is展开更多
In this paper, the direct photooxidation mechanism of near-infrared absorbing benzothiazolone cyanine dye has been studied by VIS absorption spectroscopy and Electron Spin Resonance (ESR).The technique of spin trappin...In this paper, the direct photooxidation mechanism of near-infrared absorbing benzothiazolone cyanine dye has been studied by VIS absorption spectroscopy and Electron Spin Resonance (ESR).The technique of spin trapping has been successfully applied to the detection of the photoinduced formation of singlet oxygen (1O2) and superoxide (O2-). It was reveled that the singlet oxygen and superoxide anion all contributed to the photofading of cyanine dye.展开更多
By the Grignard reaction of 1, 1-di-deutero-1-bromobutane with phthalaldehydic acid 1’,1’-di-deutero-3-n-butyl phthalide was obtained which underwent a rearrangement reaction using AlCl3 as catalyst in CS2 to give 1...By the Grignard reaction of 1, 1-di-deutero-1-bromobutane with phthalaldehydic acid 1’,1’-di-deutero-3-n-butyl phthalide was obtained which underwent a rearrangement reaction using AlCl3 as catalyst in CS2 to give 1-methyl-5-carboxy-3. 4-di-deutero-tetrahydronaphthalene. The mechanism was proposed to be a series of consecutive 1.2-hydride transfers rather than a direct 1,4-hydride展开更多
The transfer of trivalent europium ion in a liquid surfactant membrane system is investigated in order toclarify the characteristics of liquid membrane separation process and the availability of this technique forreco...The transfer of trivalent europium ion in a liquid surfactant membrane system is investigated in order toclarify the characteristics of liquid membrane separation process and the availability of this technique forrecovering trivalent lanthanides and actinides.A layered structure model for the emulsion globule is sug-gested.The equations describing the relationship among the effective membrane thickness,the time andother factors are derived and verified experimentally.Results show that under certain conditions the decreas-ing concentration of europium ion in the external phase is proportional to the square root of the time,the acidity of the internal phase and the carrier concentration in the membrane phase.The membrane phase consists of kerosene（solvent）,Span-80（surfactant）and di-（2-ethylhexyl） phosphoricacid（HDEHP,carrier）.The internal phase is dilute nitric acid and the external phase is aqueous solu-tion containing Eu（NO3）3.The mass transfer rate of europium in this system is high and the recovery ofeuropium may be more than 99%.展开更多
The basic framework of price policies for promoting renewable power de- velopment in China is introduced. The background, concept and implementation of price policies, focused on wind power, biomass power and solar po...The basic framework of price policies for promoting renewable power de- velopment in China is introduced. The background, concept and implementation of price policies, focused on wind power, biomass power and solar power, are summarized in the article. The experiences and lessons of implementation of these price policies are analyzed. It is concluded that reasonable price policy is quite effective for promoting re- newable power development. According to the requirement of China's renewable power development, the suggestions for improving renewable power pricing mechanism and price incentive policies are proposed.展开更多
To study the mechanism of repair of pancreas following acute pancreatitis (AP).Methods NIH Swiss mice were randomized into the saline control group and AP group.AP was induced by intraperitoneal injection of 50 ug/kg ...To study the mechanism of repair of pancreas following acute pancreatitis (AP).Methods NIH Swiss mice were randomized into the saline control group and AP group.AP was induced by intraperitoneal injection of 50 ug/kg body weight cearulein for 4 times,once per hour.The cellular proliferation was detected using flow cytometry.Collagen Ⅰ was detected with immunohistochemistry.Protein zymography was used to evaluate the expression of matrix metalloproteinase-3 (MMP-3).Results In the AP group,the pancreatic lesions were the severest in 8 h and then recovered on the 7th d after induction of AP.Flow cytometry showed that there were three stages of cell proliferation after AP:the active proliferation in early stage,inhibition of proliferation in middle stage and high proliferation in the late stage.The expression level of collage Ⅰ and MMP-3 was markedly higher in the AP group than in the saline control group.Conclusion The pancreas can be repaired after AP.The regeneration mechanism includes intersitial fibrosis and acinar cell replication.7 refs,4 figs.展开更多
Objective: To use network pharmacology and molecular docking technology to explore material basis and molecular mechanism of Coix lacryma-jobi, Hedyotis diffusa, Curcuma zedoaria, and Salvia chinensis on the treatment...Objective: To use network pharmacology and molecular docking technology to explore material basis and molecular mechanism of Coix lacryma-jobi, Hedyotis diffusa, Curcuma zedoaria, and Salvia chinensis on the treatment of pre-cancerous stomach diseases. Our findings provide a theoretical foundation for further clinical research. Methods: We searched and screened the targets of four pharmaceutical components for activity against precancerous lesions of gastric cancer (PLGC) using the GeneCards and OMIM network databases. The Chinese medicine composition-target network was constructed using Cytoscape3.7.2 software, and the protein interoperability network of the four drugs for PLGC treatment was constructed using the string data platform. The core target was found by topological analysis. Finally, biopathic and enrichment analyses were carried out on the drug-disease intersection target. Results: A total of 19 active ingredients and 123 component targets were collected for four enterolytic drugs. For PLGC, 1487 targets were identified, and 64 targets were collected for pharmaceutical components and diseases. A topological analysis was performed with a value greater than the mean degree (29.0), and 64 key core targets were obtained (including TP53, EGFR, TNF, and VEGFA), and the key targets were screened for TP53, EGFR, TNF, and VEGFA, among others, through network topology and protein interoperability network analyses. GO functional enrichment analysis resulted in 1337 bio-process entries, 46 cell composition entries, and 74 molecular function entries. KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway enrichment analysis and screening resulted in 254 signaling pathways, including stomach cancer, breast cancer, prostate cancer, non-small cell lung cancer, and colon cancer. Conclusion: The four enterolysis drugs may be used to prevent and control PLGC by acting on TP53, EGFR, TNF, and VEGFA targets and relevant gastric cancer, inflammatory, and immune pathways.展开更多
Nanocrystalline E and η electron compounds and supersaturated solid solution of the Cu-Sn system have been prepared by mechanical alloying of elemental Cu and Sn powders. The atomie alloying and microstructure of the...Nanocrystalline E and η electron compounds and supersaturated solid solution of the Cu-Sn system have been prepared by mechanical alloying of elemental Cu and Sn powders. The atomie alloying and microstructure of the resultant alloys have been investigated by XRD, DSC and 119Sn Mossbauer spectroscopy. A little amount of SnO2 was detected by Mossbauer spectroscopy, although no trace of diffiaction peaks occurred in the XRD pattern. Thus the spectra for all the milled samples should be fitted using two quadrupole-splitting doublets: one corre sponding to SnO2, the other corresponding to the resultant alloys. The composition dependence of the hyperfine parameters has been eXtensively discussed and explained well with respect to oxidation, sudece effect resulting from grain refinement, coordination environment asymmetry and distortion caused or/and induced by mechanical alloying.展开更多
TPPR and XPS characterizations were combined to study the reaction mechanism of CO2reforming of methane to syngas over Co/γ-Al2O3 catalysts. CH4 shows a tendency to form surface carbons by deep dissociation at high t...TPPR and XPS characterizations were combined to study the reaction mechanism of CO2reforming of methane to syngas over Co/γ-Al2O3 catalysts. CH4 shows a tendency to form surface carbons by deep dissociation at high temperatures. CO2 dissociation reaction also occurs at >673K. It is believed that carbide carbons are active species to generate CO by rcacting with o atoms dissociated from CO2. In the reaction,Co(0) particles are responsible for dissociating CH4 to form active C. abstracting an O atom from CO2 molecule, and transferring O atom to C to form CO.展开更多
基金The Sixth Batch of Special Support Plans in Anhui Province(No.dlPtzjh20200050)Key Natural Science Research Project of Higher Education Institutions in Anhui Province(No.KJ2020A0426)。
文摘Objective: To investigate the effects of Yanghe Pingchuan Granules on airway remodeling in asthmatic rats, and to explore the mechanism of Interleukin-6/Janus kinase 2/ Signal transducing activator of transcription 3(IL-6/JAK2/STAT3) signal axis. Methods: We separated 42 healthy male SD rats into two groups, a control group (7) and a model group (35).The model group was sensitized with a combination of ovalbumin (OVA) and aluminum hydroxide for 2 weeks, while the control group was given an equal amount of physiological saline.After 2 weeks, the modeling group was randomly divided into Model group, Yanghe Pingchuan Granules high, medium and low dose groups and Dexamethasone group, each group consisted of 7 animals. After 4 weeks, OVA atomization and gavage were used for stimulation and treatment. Yanghe Pingchuan Granules high, middle and low groups were given 15.48, 7.74, 3.87 g∙kg-1 Yanghe Pingchuan Granules daily, dexamethasone group was given 0.0625 mg∙kg-1 dexamethasone daily, and the other groups were given the same amount of normal saline. HE, PAS and Masson staining were used to observe the lung histopathological changes in rats. The levels of interleukin-6, IL-23 and IL-17A were detected by ELISA. The expression levels of JAK-2, P-JAK2, STAT3 and P-STAT3 in lung tissues were detected by Western blot. Real-time quantitative polymerase chain reaction (qRT-PCR) was used to detect the mRNA expression levels of IL-6, JAK2 and STAT3 in rat lung tissue. Results: The lung tissue structure of the model group was severely damaged compared to the control group, accompanied by a great many of inflammatory cell infiltration, goblet cell hyperplasia, subepithelial collagen fiber deposition and airway epithelial thickening were more obvious. The expressions of IL-6, IL- 23 and IL-17A in serum were significantly increased (P<0.01), the protein expression levels of JAK-2, P-JAK2, STAT3 and P-STAT3 and the mRNA expression levels of IL-6, JAK2 and STAT3 in lung tissue were significantly increased (P<0.01);Compared with the model group, inflammatory cell infiltration, goblet cell proliferation, subepithelial collagen fiber deposition and airway epithelial thickening were significantly reduced in each administration group, and the expressions of IL-6, IL-23 and IL-17A in serum were significantly decreased (P< 0.01). The protein expression levels of JAK-2, P-JAK2, STAT3 and P-STAT3 and mRNA expression levels of IL-6, JAK2 and STAT3 in lung tissue were significantly decreased (P<0.01). Conclusion: Yanghe Pingchuan Granules can significantly alleviate airway remodeling in asthmatic rats, and its mechanism may be through inhibiting the IL-6/JAK2/STAT3 signal axis.
基金the Jiangxi Natural Science Foundation of China[Grant No.20202BABL214050]the Sci-tech Program by Jiangxi Provincial Education Department of China[Grant No.GJJ190942].
文摘A three dimensional(3D)numerical wave flume is used to investigate carefully the ISWs(Internal solitary wave)forces acting on cylinders interacting with a stratified shear environment.Using the Large-Eddy Simulation(LES)approach and analyzing the distribution of shear stress and pressure along the surface of the cylinder,the differential pressure resistance and the viscous force are obtained.The method of multiple linear regression analysis is adopted and a comprehensive influence coefficient is determined accordingly to account for the dimensionless forces acting on the cylinder.Results show that the differential pressure resistance on a square cylinder is 1.5 times higher than that on a circular cylinder in the upper layer,while the differential pressure resistance on a square cylinder is 3.5 times larger than that on a circular cylinder in the lower layer.The viscous force is 1–2 orders of magnitude smaller than the differential pressure resistance,which means that the viscous force could be ignored.The comprehensive influence coefficient shows positive correlation with the relative wave height and negative correlation with upper and lower water depth ratio.
文摘<b>Objective:</b> The objective is to investigate whether acupuncture can protect brain by regulating the expression of ICAM-5 mRNA in brain tissue. <b>Methods:</b> Male SD rats were used to construct a middle cerebral artery occlusion reperfusion injury (Middle cerebral artery occlusion, MCAO) model, and the rats were randomly divided into 4 groups, namely the normal group (group A) and the sham operation group (group B), MCAO group (group C), MCAO + acupuncture group (group D);real-time fluorescent quantitative PCR (RT-qPCR) was used to detect the expression of ICAM-5 mRNA in the brain tissue of the ischemic area, and HE staining and TUNEL were used to detect the level of neuronal apoptosis to evaluate the therapeutic effect. <b>Results:</b> Acupuncture can improve neuronal morphology and reduce neuronal apoptosis in rats with ischemic stroke. RT-qPCR: compared with group A and group B, the expression level of ICAM-5 mRNA in the brain tissues of group C and group D decreased, while compared with group C, The expression of ICAM-5 mRNA in the brain tissue of group D was significantly up-regulated (P < 0.05). There was no statistical difference between group A and group B (P > 0.05). <b>Conclusion:</b> The effectiveness of acupuncture in the treatment of ischemic stroke may achieve neuroprotection by up-regulating the expression level of ICAM-5 mRNA.
文摘[Objectives]To screen out the main effective components of Wulan Shisanwei Decoction in the treatment of hypertension complicated with hyperlipidemia based on the method of network pharmacology,predict the target and explore the possible mechanism.[Methods]13 components of Wulan Shisanwei Decoction were searched on the TCMSP data platform,the corresponding active components were found and the corresponding targets were searched in Pubchem database.GeneCards database was used to screen the corresponding targets of hypertension and hyperlipidemia.The core target PPI network of Wulan Shisanwei Decoction in the treatment of hypertension complicated with hyperlipidemia was constructed by processing in STRING database.The effective data were imported into Cytoscape 3.8.0 to analyze the network topology parameters,and they were screened according to the degree value greater than the average value.Finally,the relevant information about the core target of Wulan Shisanwei Decoction in the treatment of hypertension complicated with hyperlipidemia was obtained.GO enrichment analysis and KEGG pathway analysis were carried out for core targets in DAVID database.The visualization map of"drug-component-target-disease"was drawn by Cytoscape 3.8.0.[Results]A total of 85 active components were obtained from Wulan Shisanwei Decoction,and there were 1532 corresponding targets.A total of 303 key targets were obtained by intersecting corresponding drug targets with disease targets.3178 biological processes were obtained by GO analysis(P<0.05)and 192 signaling pathways were obtained by KEGG enrichment analysis(P<0.05).[Conclusions]It was predicted that the main active components of Wulan Shisanwei Decoction in the treatment of hypertension complicated with hyperlipidemia were stigmasterol,acacetin,pectolinarigenin,isorhamnetin,alizarin,quercetin,nordamnacanthal,kaempferol,luteolin,glyceollin,kushenol,t,3-methylkempferol,ellagic acid,etc.20 core targets were selected in the treatment of hypertension complicated with hyperlipidemia:SRC,STAT3,HSP90AA1,MAPK1,MAPK3,PIK3R1,HRAS,GRB2,PIK3CA,AKT1,PTPN11,ESR1,LCK,EGFR,FYN,EP300,RELA,JUN,LYN,RHOA.These targets were involved in PI3K-Akt signaling pathway,lipid and atherosclerosis,proteoglycan in cancer,Ras signaling pathway,etc.to exert a response to oxidative stress,cellular response to chemical stress,peptidyl-tyrosine phosphorylation and peptide tyrosine modification,and can intervene in the early stage of the disease.It may be the potential mechanism of Wulan Shisanwei Decoction in the treatment of hypertension complicated with hyperlipidemia.
文摘Scanning tunneling microscopy (STM ) has been first employed to study the surface relief accompanying bainite transformation in a Fe-2.17C-12.18Cr-0.31Si-0.26Mn (wt pct) steel. With the exclusive vertical resolution of STM, we observed that the surface relief associated with bainite is a group of surface reliefs related to subplates, subunits and sub-subunits. As a whole, the relief group is in a tent shape, not of invariant plane strain (IPS) type, which is obviously different from that of martensite, and implying that bainite is not formed by shear mechanism. The fine structure of bainite in Fe-1.0C-4Cr-2.0Si (wt pct) alloy has also been studied with STM and TEM. It is found that the bainite plate is composed of subplates, subunits and sub-subunits. On the basis of the fine structure inside a bainitic ferrite plate observed under STM, a sympathetic-ledgewise mechanism of bainite formation is
文摘In this paper, the direct photooxidation mechanism of near-infrared absorbing benzothiazolone cyanine dye has been studied by VIS absorption spectroscopy and Electron Spin Resonance (ESR).The technique of spin trapping has been successfully applied to the detection of the photoinduced formation of singlet oxygen (1O2) and superoxide (O2-). It was reveled that the singlet oxygen and superoxide anion all contributed to the photofading of cyanine dye.
文摘By the Grignard reaction of 1, 1-di-deutero-1-bromobutane with phthalaldehydic acid 1’,1’-di-deutero-3-n-butyl phthalide was obtained which underwent a rearrangement reaction using AlCl3 as catalyst in CS2 to give 1-methyl-5-carboxy-3. 4-di-deutero-tetrahydronaphthalene. The mechanism was proposed to be a series of consecutive 1.2-hydride transfers rather than a direct 1,4-hydride
文摘The transfer of trivalent europium ion in a liquid surfactant membrane system is investigated in order toclarify the characteristics of liquid membrane separation process and the availability of this technique forrecovering trivalent lanthanides and actinides.A layered structure model for the emulsion globule is sug-gested.The equations describing the relationship among the effective membrane thickness,the time andother factors are derived and verified experimentally.Results show that under certain conditions the decreas-ing concentration of europium ion in the external phase is proportional to the square root of the time,the acidity of the internal phase and the carrier concentration in the membrane phase.The membrane phase consists of kerosene（solvent）,Span-80（surfactant）and di-（2-ethylhexyl） phosphoricacid（HDEHP,carrier）.The internal phase is dilute nitric acid and the external phase is aqueous solu-tion containing Eu（NO3）3.The mass transfer rate of europium in this system is high and the recovery ofeuropium may be more than 99%.
文摘The basic framework of price policies for promoting renewable power de- velopment in China is introduced. The background, concept and implementation of price policies, focused on wind power, biomass power and solar power, are summarized in the article. The experiences and lessons of implementation of these price policies are analyzed. It is concluded that reasonable price policy is quite effective for promoting re- newable power development. According to the requirement of China's renewable power development, the suggestions for improving renewable power pricing mechanism and price incentive policies are proposed.
文摘To study the mechanism of repair of pancreas following acute pancreatitis (AP).Methods NIH Swiss mice were randomized into the saline control group and AP group.AP was induced by intraperitoneal injection of 50 ug/kg body weight cearulein for 4 times,once per hour.The cellular proliferation was detected using flow cytometry.Collagen Ⅰ was detected with immunohistochemistry.Protein zymography was used to evaluate the expression of matrix metalloproteinase-3 (MMP-3).Results In the AP group,the pancreatic lesions were the severest in 8 h and then recovered on the 7th d after induction of AP.Flow cytometry showed that there were three stages of cell proliferation after AP:the active proliferation in early stage,inhibition of proliferation in middle stage and high proliferation in the late stage.The expression level of collage Ⅰ and MMP-3 was markedly higher in the AP group than in the saline control group.Conclusion The pancreas can be repaired after AP.The regeneration mechanism includes intersitial fibrosis and acinar cell replication.7 refs,4 figs.
文摘Objective: To use network pharmacology and molecular docking technology to explore material basis and molecular mechanism of Coix lacryma-jobi, Hedyotis diffusa, Curcuma zedoaria, and Salvia chinensis on the treatment of pre-cancerous stomach diseases. Our findings provide a theoretical foundation for further clinical research. Methods: We searched and screened the targets of four pharmaceutical components for activity against precancerous lesions of gastric cancer (PLGC) using the GeneCards and OMIM network databases. The Chinese medicine composition-target network was constructed using Cytoscape3.7.2 software, and the protein interoperability network of the four drugs for PLGC treatment was constructed using the string data platform. The core target was found by topological analysis. Finally, biopathic and enrichment analyses were carried out on the drug-disease intersection target. Results: A total of 19 active ingredients and 123 component targets were collected for four enterolytic drugs. For PLGC, 1487 targets were identified, and 64 targets were collected for pharmaceutical components and diseases. A topological analysis was performed with a value greater than the mean degree (29.0), and 64 key core targets were obtained (including TP53, EGFR, TNF, and VEGFA), and the key targets were screened for TP53, EGFR, TNF, and VEGFA, among others, through network topology and protein interoperability network analyses. GO functional enrichment analysis resulted in 1337 bio-process entries, 46 cell composition entries, and 74 molecular function entries. KEGG (Kyoto Encyclopedia of Genes and Genomes) pathway enrichment analysis and screening resulted in 254 signaling pathways, including stomach cancer, breast cancer, prostate cancer, non-small cell lung cancer, and colon cancer. Conclusion: The four enterolysis drugs may be used to prevent and control PLGC by acting on TP53, EGFR, TNF, and VEGFA targets and relevant gastric cancer, inflammatory, and immune pathways.
文摘Nanocrystalline E and η electron compounds and supersaturated solid solution of the Cu-Sn system have been prepared by mechanical alloying of elemental Cu and Sn powders. The atomie alloying and microstructure of the resultant alloys have been investigated by XRD, DSC and 119Sn Mossbauer spectroscopy. A little amount of SnO2 was detected by Mossbauer spectroscopy, although no trace of diffiaction peaks occurred in the XRD pattern. Thus the spectra for all the milled samples should be fitted using two quadrupole-splitting doublets: one corre sponding to SnO2, the other corresponding to the resultant alloys. The composition dependence of the hyperfine parameters has been eXtensively discussed and explained well with respect to oxidation, sudece effect resulting from grain refinement, coordination environment asymmetry and distortion caused or/and induced by mechanical alloying.
文摘TPPR and XPS characterizations were combined to study the reaction mechanism of CO2reforming of methane to syngas over Co/γ-Al2O3 catalysts. CH4 shows a tendency to form surface carbons by deep dissociation at high temperatures. CO2 dissociation reaction also occurs at >673K. It is believed that carbide carbons are active species to generate CO by rcacting with o atoms dissociated from CO2. In the reaction,Co(0) particles are responsible for dissociating CH4 to form active C. abstracting an O atom from CO2 molecule, and transferring O atom to C to form CO.
