AIM: To investigate the effect of serum derived from rats treated with electroacupuncture at stomach meridian acupoints on the expression of epidermal growth factor receptor (EGFR) gene in gastric mucosal cells. METHO...AIM: To investigate the effect of serum derived from rats treated with electroacupuncture at stomach meridian acupoints on the expression of epidermal growth factor receptor (EGFR) gene in gastric mucosal cells. METHODS: The stress-induced gastric mucosal injury in rat model was established by water-immersion and restrained stress methods. 52 rats were randomly divided into: normal group (n = 8), model group (n = 8), model serum group (n = 12), stomach serum group (n = 12), and gallbladder serum group (n = 12). The gastric mucosal cells were separated by pronase-EDTA digestion method and incubated with serum. The EGFR gene expression in gastric mucosal cells was detected by reverse transcription-polymerase chain reaction (RT-PCR) method. RESULTS: Compared with normal group (0.6860 ± 0.0594), the serum derived from rats of the stomach group (1.2272 ± 0.0813, P = 0.00 < 0.01) and gallbladder group (0.9640 ± 0.0387, P = 0.00 < 0.01) had a tendency to enhance the EGFR gene expression in gastric mucosal cells. Such tendency existed in the model group (0.7104 ± 0.0457) but with no signifi cant difference (P = 0.495 > 0.05) and in model serum group (0.8516 ± 0.0409) with an extremely obvious difference (P = 0.001 < 0.01). Furthermore, the EGFR gene expression in stomach serum group was significantly higher than that in gallbladder serum group (P = 0.00 < 0.01). CONCLUSION: The present study shows that serumderived from rats treated with electroacupuncture at stomach meridian acupoints can distinctly increase the EGFR gene expression of gastric mucosal cells. Therefore, there is certain meridian specificity in the serum, which could provide a proof for the TCM theory “particular relation between meridian and internal organ”.展开更多
Objective： To assess the clinical therapeutic effect of acupuncture with meridian acupoints combined with three Anmian acupoints. Methods： Sixty subjects were randomly divided into two groups： the acupuncture with ...Objective： To assess the clinical therapeutic effect of acupuncture with meridian acupoints combined with three Anmian acupoints. Methods： Sixty subjects were randomly divided into two groups： the acupuncture with meridian acupoints group （Group A）, and the acupuncture with meridian acupoints and three Anmian acupoints group （Group B） with 30 cases in each group. After 4-week treatment, the clinical therapeutic effects and scores for the Pittsburgh Sleep Quality Index （PSQI）, depression index and anxiety index were assessed in the two groups before and after treatment. Results： The total effective rate of therapy was higher in Group B （93.3%） compared with that in the Group A （66.7%, P〈0.05）. When comparing after treatment with before treatment, there were significant differences in the PSQI score of sleep quality, time to sleep, sleep time, sleep disorders in Group A （P〈0.05） and significant differences in the PSQI score of sleep quality, time to sleep, sleep time, sleep disorders and daytime disorders in Group B （P〈0.01 or P〈0.05）. There were significant differences in total PSQI score between Group A and Group B （P〈0.05）. Both groups improved the depression and anxiety state of the patients, but acupuncture with meddian acupoints combined with three Anmian acupoints was more effective than meridian acupoints alone （P〈0.05）. Conclusion： Acupuncture with meridian acupoints combined with three Anmian acupoints can improve the sleeping quality of patients with insomnia.展开更多
Objective To explore the relationship between connexin 43 and acupoints and meridians. Methods we detected one major skin gap junction connexin （connexin43, Cx43） in meridians and acupoints, and studied the expressi...Objective To explore the relationship between connexin 43 and acupoints and meridians. Methods we detected one major skin gap junction connexin （connexin43, Cx43） in meridians and acupoints, and studied the expression of Cx43 in Zusanli （足三里 ST 36） acupoints compared with control non-acupoint regions in rats after acupuncture treatments. The expression of Cx43 was detected by using immunohisto- chemistry, immunoblotting, and RT-PCR for Cx43 protein and mRNA level. Results The results showed much more abundant Cx43 expression in some cells in the skin and subcutaneous tissue of rat at ST 36 acupoints and bladder and kidney meridians than that of in the controls. The mRNA and protein levels of Cx43 in acupoints were significantly higher than those of in the control points in non-acupuncture groups and even more so after acupuncture treatments. Conclusion Our research implied that connexins and gap junctions could have a close relationship to acupoints and meridians, and gap junctional intercellular communication might play an important role in the effect of acupuncture.展开更多
At present, the specificity of meridians and acupoints has been studied using functional brain imaging techniques from many standpoints, including meridians, acupoints, and sham acupoints, as well as different meridia...At present, the specificity of meridians and acupoints has been studied using functional brain imaging techniques from many standpoints, including meridians, acupoints, and sham acupoints, as well as different meridians and acupoints, coordination of acupoints, and factors influencing meridian and acupoint specificity Preliminary experimental data have demonstrated that acupuncture at meridians and acupoints is specific with regard to brain neural information. However, research findings are contradictory, which may be related to brain functional complexity, resolution of functional brain imaging techniques, and experimental design. Future studies should further improve study method, and should strictly control experimental conditions to better analyze experimental data and acquire more beneficial data. Because of its many advantages, the functional brain imaging technique is a promising method for studying meridian and acupoint specificity.展开更多
Objective: To observe the segmental distribution of afferent Electroacupuncture (EA) signals from acupoints of the Pericardium (PC) Meridian and try to analyze the relative specificity of running route of PC Meridian....Objective: To observe the segmental distribution of afferent Electroacupuncture (EA) signals from acupoints of the Pericardium (PC) Meridian and try to analyze the relative specificity of running route of PC Meridian.Methods: A total of 85 Wistar rats anesthetized with mixed solution of Chloralose (5 mg/100 g) and Urethane (42 mg/100g) were used in this study. Under microscopic observation, the micro-filaments of the distal end of the dorsal root were carefully separated after tearing the spinal pia mater to attach to a recording electrode. The reference electrode was placed beneath the skin of the incision. Two caudal and two rostral dorsal roots near the recorded one were cut off separately. Electrical activity of the isolated micro-filaments was observed before and after EA of "Daling" (PC 7) -"Jianshi" (PC 5), "Quze" (PC 3) of PC Meridian, "Yangchi"(TE 4)- "Zhigou" (TE 6), "Tianjing" (TE 10)-" Qin-glengyuan" (TE 11) of the Triple Energizer (TE) Meridian with electric current 1 mA and 2 mA and double pulses. Results: ① After EA (1 mA) of "Daling"(PC 7)-"Jianshi"(PC 5), the firing rates of 3 out of 10 (33.3%) micro-filaments in C5 segment, 5 out of 10 (50.0%) in C6, 7 out of 10 (70.0%) in 07, 3 out of 10 (30.0%) in C8 and 3 out of 13 (23. 1%) in T1 increased considerably；and after EA of "Quze" (PC 3), those of 3/10 of C5, 4/10 of C6, 6/10 of C7, 3/10 of C8, and 3/10 of T1 increased significantly. ② After EA (1 mA) of "Yangchi"(TE 4)- "Zhigou" (TE 6) and "Tianjing" (TE 10)- "Qinglengyuan" (TE 11). the firing rates of 2/10, 2/10 of micro-filaments In C5, 7/10, 3/10 of C6, 5/10 and 4/10 of C7, 1/10 and 1/10 of C8, and 2/13 and 1/10 of T1 increased significantly. It indicates that C7 dorsal root may play the first important role in conveying EA signals from PC Meridian acupoints to the spinal cord, while C6 and C7 may be mainly responsible for conveying EA signals from TE Meridian acupoints to the spinal cord. Conclusion: The peripheral afferent pathway for transmitting EA signals from PC Meridian acupoints probably has a relative specificity.展开更多
Objective:To stimulate tenderness points around knee joint in two metholds-corresponding acupoints selected from recent regions along meridians and anatomical structures,to compare the clinical efficacy of neddle knif...Objective:To stimulate tenderness points around knee joint in two metholds-corresponding acupoints selected from recent regions along meridians and anatomical structures,to compare the clinical efficacy of neddle knife of to cure early and middle stage knee osteoarthritis.Method:70 patients were randomly(Random Number Tables)divided into test group(acupoints selected from recent regions along meridians,n=35)and control group(anatomical structures,n=35),who were diagnosed as knee osteoarthritis.Observe the VAS(visual analogue scale),Lysholm,WOMAC(the Western Ontario and McMaster Unive rsities Osteoarthritis Index)and ROM(rang of motion)between two groups in first week,first month,third month after treatment.Recording the degree of improvement of knee joint’s pain,dysfunction and symptoms of osteoarthritis and rang of motion.Results:Within groups,the VAS,Lysholm,WOMAC and ROM were obviously different from pre-therapy scores in the third,sixth and twelfth week post-therapy(P<0.05).Between groups no significant difference were observed in the third week post-therapy about VAS,Lysholm,WOMAC scores(P>0.05).However,there were differences in the sixth,twelfth weeks post-therapy(P<0.05);compared with control group,the ROM of test group were difference in the third,sixth,twelfth weeks post-therapy(P<0.05).Conclusion:The clinical efficacy of stimulating corresponding acupoints tenderness points selected from recent regions along meridians to treat early and middle stage knee osteoarthritis was superior to anatomical structures,which can effectively relieve pain,dysfunction,symptoms of osteoarthritis of knee joint and rang of motion.展开更多
Objective To probe into whether an acupoint-like and meridian-like structure was existed in platyfish. Methods Adult platyfish was put in 30 μM 4-Di-2-ASP water solution for 3 h, then, in pipe water for 20min, afterw...Objective To probe into whether an acupoint-like and meridian-like structure was existed in platyfish. Methods Adult platyfish was put in 30 μM 4-Di-2-ASP water solution for 3 h, then, in pipe water for 20min, afterward, the fish was anesthetized in 10% aether water solution, and the fluorescent labeling was observed under fluorescent microscope with B-3A combination filter. Results The labels observed under the microscope were in round bright dot, a majority of dots were distributed separately and a part of them was in cluster （2- 5 dots/cluster） on various parts of the body in regular arrangement. The labels on the head were circularly distributed around the eye and two arches were formed posterior to the eye and in the inferior 3/4 quadrant. These two arches joined one arch in the anterior superior 1/4 quadrant. On the fish trunk, it was observed that the labels were distributed from the back to the abdomen along the longitudinal axis of the trunk, forming 6 lines, located on No. 2, 4, 6, 7, 8 and 9 scale rows successively on the dorsal part of fish. Each line was composed of 7 to 22 label clusters and 1 -5 labels were counted in each cluster. The labels were arranged as 3-4 lines on the tail. Conclusion 1） Acupoint-like and meridian-like structure was existed in platyfish. 2）The skin sensory organs of animal were not distributed evenly all over the body. Instead, a number of sensory organs were put together in cluster and a number of them were in linear distribution regularly along the long axis of the trunk, which was similar to the distribution of traditional meridians and acupoints.展开更多
Objective:To evaluate the clinical effect of meridian acupoint massage combined with curvature traction on sympathetic cervical spondylosis its influence on heart rate variability and norepinephrine concentration.Meth...Objective:To evaluate the clinical effect of meridian acupoint massage combined with curvature traction on sympathetic cervical spondylosis its influence on heart rate variability and norepinephrine concentration.Methods:80 patients with sympathetic cervical spondylosis were divided into the treatment group and control group randomly,with 40 patients in each group.Patients in the two groups were treated with massage on the basis of curvature traction.Among them,the treatment group was treated with meridian acupoint massage,while the control group was treated with routine massage.Each subject was treated once a day for 2 weeks.Before and after treatment,VAS,NRS,"20 score method",NDI,JOA,and Borden's method were used to evaluate the pain,sympathetic symptoms and cervical function of the two groups.At the same time,the changes of RR interval standard deviation and urine noradrenaline concentration were also observed.Finally the clinical efficacy of the two groups were evaluated.Results:The cure rate of the treatment group was 62.50%,while it was 40.00%in the control group,and the effective rate of the treatment group was 95.00%,the total effective rate of the control group was 80.00%,the treatment group was superior to the control group in both cure rate and total effective rate(P<0.05).During post-therapy,VAS score,NRS score,sympathetic symptom score,cervical physiological curvature,NDI score,and noradrenaline concentration in urine in both groups were lower than those of pre-treatment(P<0.01),JOA score and heart rate variability SDNN value were significantly higher(P<0.01),and the treatment group was superior to the control group(P<0.01).Conclusion:Meridian acupoint massage combined with curvature traction has a significant clinical effect on sympathetic cervical spondylosis,which is worth further promotion and application.展开更多
Objective:To help selecting appropriate meridians and acupoints in clinical practice and experimental study for Parkinson’s disease(PD),the rules of meridians and acupoints selection of acupuncture and moxibustion we...Objective:To help selecting appropriate meridians and acupoints in clinical practice and experimental study for Parkinson’s disease(PD),the rules of meridians and acupoints selection of acupuncture and moxibustion were analyzed in domestic and foreign clinical treatment for PD based on data mining techniques.Methods:Literature about PD treated by acupuncture and moxibustion in China and abroad was searched and selected from China National Knowledge Infrastructure and MEDLINE.Then the data from all eligible articles were extracted to establish the database of acupuncture-moxibustion for PD.The association rules of data mining techniques were used to analyze the rules of meridians and acupoints selection.Results:Totally,168 eligible articles were included and 184 acupoints were applied.The total frequency of acupoints application was 1,090 times.Those acupoints were mainly distributed in head and neck and extremities.Among all,Taichong(LR 3),Baihui(DU 20),Fengchi(GB 20),Hegu(LI 4)and Chorea-tremor Controlled Zone were the top five acupoints that had been used.Superior-inferior acupoints matching was utilized the most.As to involved meridians,Du Meridian,Dan(Gallbladder)Meridian,Dachang(Large Intestine)Meridian,and Gan(Liver)Meridian were the most popular meridians.Conclusions:The application of meridians and acupoints for PD treatment lay emphasis on the acupoints on the head,attach importance to extinguishing Gan wind,tonifying qi and blood,and nourishing sinews,and make good use of superior-inferior acupoints matching.展开更多
In the present paper, the author reports the results of acupuncture of Houding (GV 19) and other acupoints selected along the meridian for treating sciatica. A total of 92 sciatica patients were randomly divided into ...In the present paper, the author reports the results of acupuncture of Houding (GV 19) and other acupoints selected along the meridian for treating sciatica. A total of 92 sciatica patients were randomly divided into Houding group (n=62) and control group (n=30). In Houding group, patients were treated mainly with puncturing Houding (GV 19), combined with Huantiao (GB 30) when necessary. In control group, patients were treated with Huantiao (GB 30), Yanglingquan (GB 34) or Zhibian (BL 54), Weizhong (BL 40), Chengshan (BL 57), Kunlun (BL 60), etc. which were selected along the route of meridian. Results indicated that following 10 sessions of treatment, in Houing and control groups, of the 62 and 30 cases, 44 and 15 were basically cured, 18 and 10 were improved, 0 and 5 failed in the treatment, with the total effective rates being 100% and 83,3% respectively. The therapeutic effect of Houding (GV 19) is significantly superior to that of acupoints selected along the meridian.展开更多
The status quo of study on specificity of meridian acupoints is summarized in this article through retrieval of relative literatures published in the recent 10 years in databases such as CNKI and SCI. The result indic...The status quo of study on specificity of meridian acupoints is summarized in this article through retrieval of relative literatures published in the recent 10 years in databases such as CNKI and SCI. The result indicates that specificity, which is brought into play through the inner biological mechanism, can be found in meridian acupoint efficacy. However, problems still remain since studies at present are still not systematic, comprehensive and scientific. In the future, relative studies should be carried out on extensive diseases and disease models with modern scientific technologies and equipments, strict as well as scientific experimental designation and evaluation methods.展开更多
Objective To analyze and compare the features and strengths of different methods for calculating the biophysical properties of meridian points,and thus propose corresponding suggestions to fully achieve the research a...Objective To analyze and compare the features and strengths of different methods for calculating the biophysical properties of meridian points,and thus propose corresponding suggestions to fully achieve the research and application value of biophysical properties of meridian points.Methods We searched and collected the literature on the imbalance of biophysical properties of meridian points between January 1,2005 and March 1,2020 in China National Knowledge Infrastructure(CNKI),Wanfang Academic Journal Full-text Database(Wanfang),Chongqing VIP Database(CQVIP)and PubMed database,and then analyzed,compared,and summarized the applied methods for calculating the imbalance degree of the biophysical properties of meridian points.Results The current methods for calculating the imbalance degree of the biophysical properties of meridian points are diverse and can be summarized as the following three:direct comparison of the measured values of the left and right namesake points,difference method,and ratio method.The low uniformity of the calculation methods has limited the promotion and application of its research results.Conclusion In future research on the biophysical properties of meridian points,multidisciplinary cooperation in terms of imbalance degree calculation methods,detection instruments,and health data models is necessary to achieve more widely applicable scientific conclusions and more generalized experimental results.展开更多
The data relevant to acupoint names and indications were extracted from two key textbooks on acupuncture, namely, New Acupuncture and Meridians and Acupoints. Based on the complex network approach, the acupoint-sympto...The data relevant to acupoint names and indications were extracted from two key textbooks on acupuncture, namely, New Acupuncture and Meridians and Acupoints. Based on the complex network approach, the acupoint-symptom network was established and changes based on the acupoint number were analyzed to highlight the agreement and congruence between these two textbooks, including indication rules. Using topological data, the reasons for the differences were explained to provide specific ideas and methods for the structural development and standardization of the traditional acupuncture knowledge system. In this study, 386 acupoints, 773 symptoms, and 152,163 acupoint-matched pairs from New Acupuncture and 403 acupoints, 253 symptoms, and 28,755 acupoint-matched pairs from Meridians and Acupoints were included. The results highlighted that there are numerous differences in the acupoint-symptom network between these two textbooks. The model of New Acupuncture displays a more typical small-world effect, which may reflect the advantage of classification by symptoms. Furthermore, many of the variations in acupoint locations and indications between these two textbooks reflect the discipline's development over time.展开更多
基金Supported by the National Natural Science Foundation of China, No. 90209023 the State 973 Project, No. 2005CB523308
文摘AIM: To investigate the effect of serum derived from rats treated with electroacupuncture at stomach meridian acupoints on the expression of epidermal growth factor receptor (EGFR) gene in gastric mucosal cells. METHODS: The stress-induced gastric mucosal injury in rat model was established by water-immersion and restrained stress methods. 52 rats were randomly divided into: normal group (n = 8), model group (n = 8), model serum group (n = 12), stomach serum group (n = 12), and gallbladder serum group (n = 12). The gastric mucosal cells were separated by pronase-EDTA digestion method and incubated with serum. The EGFR gene expression in gastric mucosal cells was detected by reverse transcription-polymerase chain reaction (RT-PCR) method. RESULTS: Compared with normal group (0.6860 ± 0.0594), the serum derived from rats of the stomach group (1.2272 ± 0.0813, P = 0.00 < 0.01) and gallbladder group (0.9640 ± 0.0387, P = 0.00 < 0.01) had a tendency to enhance the EGFR gene expression in gastric mucosal cells. Such tendency existed in the model group (0.7104 ± 0.0457) but with no signifi cant difference (P = 0.495 > 0.05) and in model serum group (0.8516 ± 0.0409) with an extremely obvious difference (P = 0.001 < 0.01). Furthermore, the EGFR gene expression in stomach serum group was significantly higher than that in gallbladder serum group (P = 0.00 < 0.01). CONCLUSION: The present study shows that serumderived from rats treated with electroacupuncture at stomach meridian acupoints can distinctly increase the EGFR gene expression of gastric mucosal cells. Therefore, there is certain meridian specificity in the serum, which could provide a proof for the TCM theory “particular relation between meridian and internal organ”.
文摘Objective： To assess the clinical therapeutic effect of acupuncture with meridian acupoints combined with three Anmian acupoints. Methods： Sixty subjects were randomly divided into two groups： the acupuncture with meridian acupoints group （Group A）, and the acupuncture with meridian acupoints and three Anmian acupoints group （Group B） with 30 cases in each group. After 4-week treatment, the clinical therapeutic effects and scores for the Pittsburgh Sleep Quality Index （PSQI）, depression index and anxiety index were assessed in the two groups before and after treatment. Results： The total effective rate of therapy was higher in Group B （93.3%） compared with that in the Group A （66.7%, P〈0.05）. When comparing after treatment with before treatment, there were significant differences in the PSQI score of sleep quality, time to sleep, sleep time, sleep disorders in Group A （P〈0.05） and significant differences in the PSQI score of sleep quality, time to sleep, sleep time, sleep disorders and daytime disorders in Group B （P〈0.01 or P〈0.05）. There were significant differences in total PSQI score between Group A and Group B （P〈0.05）. Both groups improved the depression and anxiety state of the patients, but acupuncture with meddian acupoints combined with three Anmian acupoints was more effective than meridian acupoints alone （P〈0.05）. Conclusion： Acupuncture with meridian acupoints combined with three Anmian acupoints can improve the sleeping quality of patients with insomnia.
基金supported by grants from National Natural Science Foundation of China (No .90209009)National Basic Research Program(No .2006CB504502)~~
文摘Objective To explore the relationship between connexin 43 and acupoints and meridians. Methods we detected one major skin gap junction connexin （connexin43, Cx43） in meridians and acupoints, and studied the expression of Cx43 in Zusanli （足三里 ST 36） acupoints compared with control non-acupoint regions in rats after acupuncture treatments. The expression of Cx43 was detected by using immunohisto- chemistry, immunoblotting, and RT-PCR for Cx43 protein and mRNA level. Results The results showed much more abundant Cx43 expression in some cells in the skin and subcutaneous tissue of rat at ST 36 acupoints and bladder and kidney meridians than that of in the controls. The mRNA and protein levels of Cx43 in acupoints were significantly higher than those of in the control points in non-acupuncture groups and even more so after acupuncture treatments. Conclusion Our research implied that connexins and gap junctions could have a close relationship to acupoints and meridians, and gap junctional intercellular communication might play an important role in the effect of acupuncture.
基金Major State Basic Research Development Program of China (973 Program), No.2006CB504501
文摘At present, the specificity of meridians and acupoints has been studied using functional brain imaging techniques from many standpoints, including meridians, acupoints, and sham acupoints, as well as different meridians and acupoints, coordination of acupoints, and factors influencing meridian and acupoint specificity Preliminary experimental data have demonstrated that acupuncture at meridians and acupoints is specific with regard to brain neural information. However, research findings are contradictory, which may be related to brain functional complexity, resolution of functional brain imaging techniques, and experimental design. Future studies should further improve study method, and should strictly control experimental conditions to better analyze experimental data and acquire more beneficial data. Because of its many advantages, the functional brain imaging technique is a promising method for studying meridian and acupoint specificity.
文摘Objective: To observe the segmental distribution of afferent Electroacupuncture (EA) signals from acupoints of the Pericardium (PC) Meridian and try to analyze the relative specificity of running route of PC Meridian.Methods: A total of 85 Wistar rats anesthetized with mixed solution of Chloralose (5 mg/100 g) and Urethane (42 mg/100g) were used in this study. Under microscopic observation, the micro-filaments of the distal end of the dorsal root were carefully separated after tearing the spinal pia mater to attach to a recording electrode. The reference electrode was placed beneath the skin of the incision. Two caudal and two rostral dorsal roots near the recorded one were cut off separately. Electrical activity of the isolated micro-filaments was observed before and after EA of "Daling" (PC 7) -"Jianshi" (PC 5), "Quze" (PC 3) of PC Meridian, "Yangchi"(TE 4)- "Zhigou" (TE 6), "Tianjing" (TE 10)-" Qin-glengyuan" (TE 11) of the Triple Energizer (TE) Meridian with electric current 1 mA and 2 mA and double pulses. Results: ① After EA (1 mA) of "Daling"(PC 7)-"Jianshi"(PC 5), the firing rates of 3 out of 10 (33.3%) micro-filaments in C5 segment, 5 out of 10 (50.0%) in C6, 7 out of 10 (70.0%) in 07, 3 out of 10 (30.0%) in C8 and 3 out of 13 (23. 1%) in T1 increased considerably；and after EA of "Quze" (PC 3), those of 3/10 of C5, 4/10 of C6, 6/10 of C7, 3/10 of C8, and 3/10 of T1 increased significantly. ② After EA (1 mA) of "Yangchi"(TE 4)- "Zhigou" (TE 6) and "Tianjing" (TE 10)- "Qinglengyuan" (TE 11). the firing rates of 2/10, 2/10 of micro-filaments In C5, 7/10, 3/10 of C6, 5/10 and 4/10 of C7, 1/10 and 1/10 of C8, and 2/13 and 1/10 of T1 increased significantly. It indicates that C7 dorsal root may play the first important role in conveying EA signals from PC Meridian acupoints to the spinal cord, while C6 and C7 may be mainly responsible for conveying EA signals from TE Meridian acupoints to the spinal cord. Conclusion: The peripheral afferent pathway for transmitting EA signals from PC Meridian acupoints probably has a relative specificity.
基金Key Program of Beijing University of Traditional Chinese Medicine(No.2020-JYBZDGG-142-5)。
文摘Objective:To stimulate tenderness points around knee joint in two metholds-corresponding acupoints selected from recent regions along meridians and anatomical structures,to compare the clinical efficacy of neddle knife of to cure early and middle stage knee osteoarthritis.Method:70 patients were randomly(Random Number Tables)divided into test group(acupoints selected from recent regions along meridians,n=35)and control group(anatomical structures,n=35),who were diagnosed as knee osteoarthritis.Observe the VAS(visual analogue scale),Lysholm,WOMAC(the Western Ontario and McMaster Unive rsities Osteoarthritis Index)and ROM(rang of motion)between two groups in first week,first month,third month after treatment.Recording the degree of improvement of knee joint’s pain,dysfunction and symptoms of osteoarthritis and rang of motion.Results:Within groups,the VAS,Lysholm,WOMAC and ROM were obviously different from pre-therapy scores in the third,sixth and twelfth week post-therapy(P<0.05).Between groups no significant difference were observed in the third week post-therapy about VAS,Lysholm,WOMAC scores(P>0.05).However,there were differences in the sixth,twelfth weeks post-therapy(P<0.05);compared with control group,the ROM of test group were difference in the third,sixth,twelfth weeks post-therapy(P<0.05).Conclusion:The clinical efficacy of stimulating corresponding acupoints tenderness points selected from recent regions along meridians to treat early and middle stage knee osteoarthritis was superior to anatomical structures,which can effectively relieve pain,dysfunction,symptoms of osteoarthritis of knee joint and rang of motion.
文摘Objective To probe into whether an acupoint-like and meridian-like structure was existed in platyfish. Methods Adult platyfish was put in 30 μM 4-Di-2-ASP water solution for 3 h, then, in pipe water for 20min, afterward, the fish was anesthetized in 10% aether water solution, and the fluorescent labeling was observed under fluorescent microscope with B-3A combination filter. Results The labels observed under the microscope were in round bright dot, a majority of dots were distributed separately and a part of them was in cluster （2- 5 dots/cluster） on various parts of the body in regular arrangement. The labels on the head were circularly distributed around the eye and two arches were formed posterior to the eye and in the inferior 3/4 quadrant. These two arches joined one arch in the anterior superior 1/4 quadrant. On the fish trunk, it was observed that the labels were distributed from the back to the abdomen along the longitudinal axis of the trunk, forming 6 lines, located on No. 2, 4, 6, 7, 8 and 9 scale rows successively on the dorsal part of fish. Each line was composed of 7 to 22 label clusters and 1 -5 labels were counted in each cluster. The labels were arranged as 3-4 lines on the tail. Conclusion 1） Acupoint-like and meridian-like structure was existed in platyfish. 2）The skin sensory organs of animal were not distributed evenly all over the body. Instead, a number of sensory organs were put together in cluster and a number of them were in linear distribution regularly along the long axis of the trunk, which was similar to the distribution of traditional meridians and acupoints.
基金National Administration of Traditional Chinese Medicine Longjiang School of Medicine Inheritance Studio construction project(No.LPGZS2012-14)
文摘Objective:To evaluate the clinical effect of meridian acupoint massage combined with curvature traction on sympathetic cervical spondylosis its influence on heart rate variability and norepinephrine concentration.Methods:80 patients with sympathetic cervical spondylosis were divided into the treatment group and control group randomly,with 40 patients in each group.Patients in the two groups were treated with massage on the basis of curvature traction.Among them,the treatment group was treated with meridian acupoint massage,while the control group was treated with routine massage.Each subject was treated once a day for 2 weeks.Before and after treatment,VAS,NRS,"20 score method",NDI,JOA,and Borden's method were used to evaluate the pain,sympathetic symptoms and cervical function of the two groups.At the same time,the changes of RR interval standard deviation and urine noradrenaline concentration were also observed.Finally the clinical efficacy of the two groups were evaluated.Results:The cure rate of the treatment group was 62.50%,while it was 40.00%in the control group,and the effective rate of the treatment group was 95.00%,the total effective rate of the control group was 80.00%,the treatment group was superior to the control group in both cure rate and total effective rate(P<0.05).During post-therapy,VAS score,NRS score,sympathetic symptom score,cervical physiological curvature,NDI score,and noradrenaline concentration in urine in both groups were lower than those of pre-treatment(P<0.01),JOA score and heart rate variability SDNN value were significantly higher(P<0.01),and the treatment group was superior to the control group(P<0.01).Conclusion:Meridian acupoint massage combined with curvature traction has a significant clinical effect on sympathetic cervical spondylosis,which is worth further promotion and application.
基金Supported by Scientific Research Foundation for PostdoctorGuangzhou Postdoctoral International Training Program Funding Project+2 种基金HUANG Huang Academic Experiences Heritage Workshop(No.E43723)Science and Technology Special Project(No.yk2013b2n16)funded by Guangdong Provincial Hospital of Chinese Medicine2013 Famous Veteran Traditional Chinese Medicine Doctors Heritage Workshop Construction Program funded by State Administration of Traditional Chinese Medicine[No.2013(47)]。
文摘Objective:To help selecting appropriate meridians and acupoints in clinical practice and experimental study for Parkinson’s disease(PD),the rules of meridians and acupoints selection of acupuncture and moxibustion were analyzed in domestic and foreign clinical treatment for PD based on data mining techniques.Methods:Literature about PD treated by acupuncture and moxibustion in China and abroad was searched and selected from China National Knowledge Infrastructure and MEDLINE.Then the data from all eligible articles were extracted to establish the database of acupuncture-moxibustion for PD.The association rules of data mining techniques were used to analyze the rules of meridians and acupoints selection.Results:Totally,168 eligible articles were included and 184 acupoints were applied.The total frequency of acupoints application was 1,090 times.Those acupoints were mainly distributed in head and neck and extremities.Among all,Taichong(LR 3),Baihui(DU 20),Fengchi(GB 20),Hegu(LI 4)and Chorea-tremor Controlled Zone were the top five acupoints that had been used.Superior-inferior acupoints matching was utilized the most.As to involved meridians,Du Meridian,Dan(Gallbladder)Meridian,Dachang(Large Intestine)Meridian,and Gan(Liver)Meridian were the most popular meridians.Conclusions:The application of meridians and acupoints for PD treatment lay emphasis on the acupoints on the head,attach importance to extinguishing Gan wind,tonifying qi and blood,and nourishing sinews,and make good use of superior-inferior acupoints matching.
文摘In the present paper, the author reports the results of acupuncture of Houding (GV 19) and other acupoints selected along the meridian for treating sciatica. A total of 92 sciatica patients were randomly divided into Houding group (n=62) and control group (n=30). In Houding group, patients were treated mainly with puncturing Houding (GV 19), combined with Huantiao (GB 30) when necessary. In control group, patients were treated with Huantiao (GB 30), Yanglingquan (GB 34) or Zhibian (BL 54), Weizhong (BL 40), Chengshan (BL 57), Kunlun (BL 60), etc. which were selected along the route of meridian. Results indicated that following 10 sessions of treatment, in Houing and control groups, of the 62 and 30 cases, 44 and 15 were basically cured, 18 and 10 were improved, 0 and 5 failed in the treatment, with the total effective rates being 100% and 83,3% respectively. The therapeutic effect of Houding (GV 19) is significantly superior to that of acupoints selected along the meridian.
基金Supported by National Program on Key Basic Research Project (973 Program): 2010 CB 530506
文摘The status quo of study on specificity of meridian acupoints is summarized in this article through retrieval of relative literatures published in the recent 10 years in databases such as CNKI and SCI. The result indicates that specificity, which is brought into play through the inner biological mechanism, can be found in meridian acupoint efficacy. However, problems still remain since studies at present are still not systematic, comprehensive and scientific. In the future, relative studies should be carried out on extensive diseases and disease models with modern scientific technologies and equipments, strict as well as scientific experimental designation and evaluation methods.
文摘Objective To analyze and compare the features and strengths of different methods for calculating the biophysical properties of meridian points,and thus propose corresponding suggestions to fully achieve the research and application value of biophysical properties of meridian points.Methods We searched and collected the literature on the imbalance of biophysical properties of meridian points between January 1,2005 and March 1,2020 in China National Knowledge Infrastructure(CNKI),Wanfang Academic Journal Full-text Database(Wanfang),Chongqing VIP Database(CQVIP)and PubMed database,and then analyzed,compared,and summarized the applied methods for calculating the imbalance degree of the biophysical properties of meridian points.Results The current methods for calculating the imbalance degree of the biophysical properties of meridian points are diverse and can be summarized as the following three:direct comparison of the measured values of the left and right namesake points,difference method,and ratio method.The low uniformity of the calculation methods has limited the promotion and application of its research results.Conclusion In future research on the biophysical properties of meridian points,multidisciplinary cooperation in terms of imbalance degree calculation methods,detection instruments,and health data models is necessary to achieve more widely applicable scientific conclusions and more generalized experimental results.
基金Supported by the National College Students’innovation and entrepreneurship training program:201,910,315,018The Open Projects of the Discipline of Chinese Medicine of Nanjing University of Chinese Medicine Supported by the Subject of Academic priority discipline of Jiangsu Higher Education Institutions:ZYX03KF012the Scientific research project of Nanjing University of Chinese Medicine:XT202,001。
文摘The data relevant to acupoint names and indications were extracted from two key textbooks on acupuncture, namely, New Acupuncture and Meridians and Acupoints. Based on the complex network approach, the acupoint-symptom network was established and changes based on the acupoint number were analyzed to highlight the agreement and congruence between these two textbooks, including indication rules. Using topological data, the reasons for the differences were explained to provide specific ideas and methods for the structural development and standardization of the traditional acupuncture knowledge system. In this study, 386 acupoints, 773 symptoms, and 152,163 acupoint-matched pairs from New Acupuncture and 403 acupoints, 253 symptoms, and 28,755 acupoint-matched pairs from Meridians and Acupoints were included. The results highlighted that there are numerous differences in the acupoint-symptom network between these two textbooks. The model of New Acupuncture displays a more typical small-world effect, which may reflect the advantage of classification by symptoms. Furthermore, many of the variations in acupoint locations and indications between these two textbooks reflect the discipline's development over time.
