Objective: To study the composition of microecosystem in ostiomeatal complex (OMC) of adults and the changes via functional endoscopic sinus surgery. Methods: 220 adults with chronic sinusitis(20 as control) were clas...Objective: To study the composition of microecosystem in ostiomeatal complex (OMC) of adults and the changes via functional endoscopic sinus surgery. Methods: 220 adults with chronic sinusitis(20 as control) were classified into pre- and post-operative groups, and categorised according to its type of sinusitis. Swab specimens were taken from three different sites of ostiomeatal complex in each individual, and cultivations and identifications of aerobes, anaerobes and fungi were performed simultaneously. The microecosystem was analysed. Results: Cultured aerobes belonged to 30 species from 13 genera, anaerobes species, and fungi 3 major species, most of which have none or less virulence. The difference of mi-croecological status between type Ⅰ and Ⅱ was not significant (P > 0.05). Aerobic culture rates between preoperative group and control group had significance(P < 0.01);culture rate descended in postoperative group while the difference was not significant compared to preoperative group (P > 0. 05); difference of rate of same aerobic culture from three sites (RSAC) , which reflects the microecological integrity of OMC, between preoperative and control group was significant (P < 0.01), while was not between postoperative group and control one(P > 0. 05). Taking fungi into account, differences among all groups had no significance(P>0.05); anaerobes were rare in all groups. Conclusion: Being a microecosystem under normal condition, ostiomeatal complex is relatively clean and exists as a whole space. Chronic inflammations separate different parts of which from each other with multimicrobial existence.FESS reverses separation of the microecosystem and rebuild it as a whole again, thus promote the recovery.展开更多
背景高危型人乳头瘤病毒(high risk human papillomavirus,HR-HPV)感染并不一定会导致癌前病变或宫颈癌,阴道微生物多样性的改变可能是造成HPV持续感染继而发生宫颈病变的伴随因素。目的探讨阴道微生态改变与HRHPV感染的相关性,为宫颈...背景高危型人乳头瘤病毒(high risk human papillomavirus,HR-HPV)感染并不一定会导致癌前病变或宫颈癌,阴道微生物多样性的改变可能是造成HPV持续感染继而发生宫颈病变的伴随因素。目的探讨阴道微生态改变与HRHPV感染的相关性,为宫颈癌的防治提供参考。方法选取2021年10月-2022年3月就诊于解放军总医院第一医学中心妇产科门诊,同时行阴道分泌物微生态检测及人乳头瘤病毒基因分型检测的324例患者(年龄21~72岁)为研究对象,分析阴道微生态异常与HR-HPV感染的相关性。结果324例患者中HR-HPV阳性71例,阳性率21.91%(71/324);阴道微生态正常的178例中HR-HPV阳性43例,阳性率24.16%(43/178);阴道微生态异常的146例中HR-HPV阳性28例,阳性率19.18%(28/146)。阴道微生态异常结果中细菌性阴道病(bacterial vaginosis,BV)及BV中间型37例,HR-HPV阳性率40.54%(15/37);菌群抑制32例,HR-HPV阳性率18.75%(6/32);阴道菌群正常存在炎症反应77例,HR-HPV阳性率9.09%(7/77)。阴道微生态正常组与菌群抑制组HPV阳性率差异无统计学意义(P>0.05);与BV及BV中间型组、阴道菌群正常存在炎症反应组的HPV阳性率差异均有统计学意义(P<0.05)。Logistic回归分析显示,BV及BV中间型发生HR-HPV感染的概率更高(OR=2.240,P=0.030)、阴道菌群正常存在炎症反应者HR-HPV感染的概率更低(OR=0.329,P=0.009)。结论BV及单纯白细胞增多引起的阴道微生态改变与HR-HPV感染密切相关。展开更多
文摘Objective: To study the composition of microecosystem in ostiomeatal complex (OMC) of adults and the changes via functional endoscopic sinus surgery. Methods: 220 adults with chronic sinusitis(20 as control) were classified into pre- and post-operative groups, and categorised according to its type of sinusitis. Swab specimens were taken from three different sites of ostiomeatal complex in each individual, and cultivations and identifications of aerobes, anaerobes and fungi were performed simultaneously. The microecosystem was analysed. Results: Cultured aerobes belonged to 30 species from 13 genera, anaerobes species, and fungi 3 major species, most of which have none or less virulence. The difference of mi-croecological status between type Ⅰ and Ⅱ was not significant (P > 0.05). Aerobic culture rates between preoperative group and control group had significance(P < 0.01);culture rate descended in postoperative group while the difference was not significant compared to preoperative group (P > 0. 05); difference of rate of same aerobic culture from three sites (RSAC) , which reflects the microecological integrity of OMC, between preoperative and control group was significant (P < 0.01), while was not between postoperative group and control one(P > 0. 05). Taking fungi into account, differences among all groups had no significance(P>0.05); anaerobes were rare in all groups. Conclusion: Being a microecosystem under normal condition, ostiomeatal complex is relatively clean and exists as a whole space. Chronic inflammations separate different parts of which from each other with multimicrobial existence.FESS reverses separation of the microecosystem and rebuild it as a whole again, thus promote the recovery.
文摘背景高危型人乳头瘤病毒(high risk human papillomavirus,HR-HPV)感染并不一定会导致癌前病变或宫颈癌,阴道微生物多样性的改变可能是造成HPV持续感染继而发生宫颈病变的伴随因素。目的探讨阴道微生态改变与HRHPV感染的相关性,为宫颈癌的防治提供参考。方法选取2021年10月-2022年3月就诊于解放军总医院第一医学中心妇产科门诊,同时行阴道分泌物微生态检测及人乳头瘤病毒基因分型检测的324例患者(年龄21~72岁)为研究对象,分析阴道微生态异常与HR-HPV感染的相关性。结果324例患者中HR-HPV阳性71例,阳性率21.91%(71/324);阴道微生态正常的178例中HR-HPV阳性43例,阳性率24.16%(43/178);阴道微生态异常的146例中HR-HPV阳性28例,阳性率19.18%(28/146)。阴道微生态异常结果中细菌性阴道病(bacterial vaginosis,BV)及BV中间型37例,HR-HPV阳性率40.54%(15/37);菌群抑制32例,HR-HPV阳性率18.75%(6/32);阴道菌群正常存在炎症反应77例,HR-HPV阳性率9.09%(7/77)。阴道微生态正常组与菌群抑制组HPV阳性率差异无统计学意义(P>0.05);与BV及BV中间型组、阴道菌群正常存在炎症反应组的HPV阳性率差异均有统计学意义(P<0.05)。Logistic回归分析显示,BV及BV中间型发生HR-HPV感染的概率更高(OR=2.240,P=0.030)、阴道菌群正常存在炎症反应者HR-HPV感染的概率更低(OR=0.329,P=0.009)。结论BV及单纯白细胞增多引起的阴道微生态改变与HR-HPV感染密切相关。
