期刊文献+
共找到5篇文章
< 1 >
每页显示 20 50 100
Association between the Neutrophil-to-lymphocyte Ratio and New-onset Subclinical Macrovascular and Microvascular Diseases in the Chinese Population
1
作者 WANG Jia Lu CAO Qiu Yu +12 位作者 XIN Zhuo Jun LIU Shan Shan XU Min WANG Tian Ge LU Jie Li CHEN Yu Hong WANG Shuang Yuan ZHAO Zhi Yun XU Yu NING Guang WANG Wei Qing BI Yu Fang LI Mian 《Biomedical and Environmental Sciences》 SCIE CAS CSCD 2022年第1期4-12,共9页
Objective The association between neutrophil-to-lymphocyte ratio(NLR)with subclinical macrovascular and microvascular diseases has been less investigated.We sought to examine the association between NLR and new-onset ... Objective The association between neutrophil-to-lymphocyte ratio(NLR)with subclinical macrovascular and microvascular diseases has been less investigated.We sought to examine the association between NLR and new-onset subclinical macrovascular and microvascular abnormalities in the Chinese population.Methods From a community cohort,we included 6,430 adults aged≥40 years without subclinical macrovascular and microvascular diseases at baseline.We measured subclinical macrovascular and microvascular abnormalities separately using the ankle-brachial index(ABI),brachial-ankle pulse wave velocity(baPWV),and albuminuria.Results During a mean follow-up of 4.3 years,110 participants developed incident abnormal ABI,746 participants developed incident elevated baPWV,and 503 participants developed incident albuminuria.Poisson regression analysis indicated that NLR was significantly associated with an increased risk of newonset abnormal ABI,elevated baPWV,and albuminuria.Compared to overweight/obese participants,we found a much stronger association between NLR and subclinical vascular abnormalities in participants with normal weight.Furthermore,we found an interaction between the NLR and body mass index(BMI)on the risk of new-onset abnormal ABI(P for interaction:0.01).Conclusion NLR was associated with subclinical macrovascular and microvascular diseases in the Chinese population.Furthermore,in participants with normal weight,the association between NLR and subclinical vascular abnormalities was much stronger. 展开更多
关键词 Neutrophil-to-lymphocyte ratio Subclinical macrovascular and microvascular diseases Body mass index Prospective cohort study
下载PDF
Concepts and opportunities for repair in cerebral microvascular disease and white matter stroke
2
作者 Guanxi Xiao Jason D.Hinman 《Neural Regeneration Research》 SCIE CAS CSCD 2016年第9期1398-1400,共3页
Diffuse changes in white matter resulting from cerebral microvascular disease contribute to cognitive impairment (Jokinen et al., 2011), declines in global functionality (Inzitari et al., 2009), and even death (D... Diffuse changes in white matter resulting from cerebral microvascular disease contribute to cognitive impairment (Jokinen et al., 2011), declines in global functionality (Inzitari et al., 2009), and even death (Debette and Markus, 2010). Twenty years ago, estimations of the clinical incidence of ce- rebral microvascular disease approached 11 million per year in the US alone (Leary and Saver, 2003). More recent estima- tions suggest the prevalence of diffuse white matter disease and silent brain infarction approaches 20% and increases dramatically in the presence of cardiovascular risk factors (Fanning et al., 2014). 展开更多
关键词 Concepts and opportunities for repair in cerebral microvascular disease and white matter stroke
下载PDF
Pericyte and microvascular diseases
3
作者 刘中砚 杨镇 《China Medical Abstracts》 2006年第1期73-77,共5页
Pericytes are perivascular cells of microcirculation, which construct the barrier between the microcircula-tion and interstitial fluid with endothelial cell and basement membrane. Contractility and other multifunction... Pericytes are perivascular cells of microcirculation, which construct the barrier between the microcircula-tion and interstitial fluid with endothelial cell and basement membrane. Contractility and other multifunctional activities of pericytes are now being elucidated. Pericytes are pluripotential cells (i. e. as a source of other cell types)and take part in many biological and pathological procedures, such as vascularization, vascular remodeling , microvessel permeability and wound healing, etc. The functional interaction of pericytes with endothelial cells (EC) is now being established. The disfunction and population alteration of pericytes are characterized in many microvascular diseases, such as diabetic retinopa-thy, vascularization of tumors, hypertension,etc. 展开更多
关键词 PERICYTE microvascular diseases portal hypertension
下载PDF
ATP Stress Myocardial Contrast Echocardiography Assessment of Coronary Microvascular Disease with Spasmodic Characteristics: A Case Report
4
作者 Xuebing Liu Chunmei Li 《Cardiology Discovery》 2023年第3期221-225,共5页
Here, a patient with chest pain and <50% stenosis on coronary angiography, where ATP stress myocardial contrast echocardiography (MCE) revealed that coronary flow reserve was reduced to 1.71 was presented. Perfusio... Here, a patient with chest pain and <50% stenosis on coronary angiography, where ATP stress myocardial contrast echocardiography (MCE) revealed that coronary flow reserve was reduced to 1.71 was presented. Perfusion delay occurred in the left ventricular wall of the apex of the heart before ATP stress, and the perfusion delay area was significantly reduced at peak stress. Similar to the characteristics of "reverse redistribution" of radionuclide myocardium perfusion in coronary vasospasm, the delayed perfusion area in the recovery period was larger than that detected before stress. Together with increased spectral resistance of the distal segment of left anterior descending coronary artery and chest pain, these findings indicated coronary microvascular disease with spasmodic characteristics in this patient. The perfusion characteristics on ATP stress determined by MCE and changes in coronary spectrum have value for the diagnosis and treatment of coronary microvascular disease with spasmodic characteristics. 展开更多
关键词 ECHOCARDIOGRAPHY STRESS Myocardial contrast echocardiography Coronary microvascular disease SPASM Coronary artery blood flow reserve Case report
原文传递
Diabetes and cognitive decline:Challenges and future direction
5
作者 Norhamidar Ab-Hamid Norsuhana Omar +1 位作者 Che Aishah Nazariah Ismail Idris Long 《World Journal of Diabetes》 SCIE 2023年第6期795-807,共13页
There is growing evidence that diabetes can induce cognitive decline and dementia.It is a slow,progressive cognitive decline that can occur in any age group,but is seen more frequently in older individuals.Symptoms re... There is growing evidence that diabetes can induce cognitive decline and dementia.It is a slow,progressive cognitive decline that can occur in any age group,but is seen more frequently in older individuals.Symptoms related to cognitive decline are worsened by chronic metabolic syndrome.Animal models are frequently utilized to elucidate the mechanisms of cognitive decline in diabetes and to assess potential drugs for therapy and prevention.This review addresses the common factors and pathophysiology involved in diabetes-related cognitive decline and outlines the various animal models used to study this condition. 展开更多
关键词 Diabetes mellitus Insulin signaling Macrovascular disease microvascular disease Animal models Cognitive decline PATHOPHYSIOLOGY
下载PDF
上一页 1 下一页 到第
使用帮助 返回顶部