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An Improved Method of Simultaneous Determination of Four Bioactive Compounds in Evodiae Fructus Using Ionic Liquids as Mobile Phase Additives in High Performance Liquid Chromatography 被引量:1
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作者 BIAN Min TIAN Ling YAO Cheng 《Chemical Research in Chinese Universities》 SCIE CAS CSCD 2017年第4期552-558,共7页
There are many compounds with different structures and chemical properties in Evodiae Fructus. It is hard to simultaneously determine the bioactive compounds by high performance liquid chromatography(HPLC). A new me... There are many compounds with different structures and chemical properties in Evodiae Fructus. It is hard to simultaneously determine the bioactive compounds by high performance liquid chromatography(HPLC). A new method was proposed for four bioactive compounds(synephrine, limonoids, evodiamine and rutecarpine) to be separated completely and determined accurately using ionic liquids(ILs) as mobile phase additives. The mechanism and the effect of the ILs for changing the chromatographic behaviors of the four compounds were studied by systemati- cally changing the pH value of mobile phase, the types and concentrations of ILs as well as the concentrations of phosphate buffer. The chromatographic behaviors of the analytes with a mobile phase containing ILs complied with the stoichiometric displacement model for retention(SDM-R). All results demonstrate the dual nature of ionic liquids, which are competitive adsorption and ion-pair agent. Meanwhile, excellent linearity was observed for all the com- pounds with correlation coefficients between 0.9992 and 0.9998. The limit of detection and the limit of quantification of the four compounds varied from 0.47μg/mL to 0.87 μg/mL and from 1.79 μg/mL to 2.44μg/mL, respectively. Three kinds of Evodiae Fructus processed through different methods were analyzed via the method. The result shows that the contents of evodiamine and rutecarpine as the two main active compounds by processing with vinegar and salt are obviously higher than those of the raw products. 展开更多
关键词 Evodiae Fructus Ionic liquid mobile phase additive High performance liquid chromatography(HPLC) Processed Evodiae Fructus
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Recent Advances on Chiral Mobile Phase Additives: A Critical Review 被引量:1
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作者 Yuan Li Xiao-Ning Jin +2 位作者 Yue Cheng Xiao-Fei Ma Yong Wang 《Journal of Analysis and Testing》 EI 2022年第2期129-162,共34页
Chirality is one of the fundamental attributes of nature, which exists in different or even completely opposite metabolic,toxicological and pharmacological properties in organisms. Consequently, obtaining enantiomeric... Chirality is one of the fundamental attributes of nature, which exists in different or even completely opposite metabolic,toxicological and pharmacological properties in organisms. Consequently, obtaining enantiomerically pure drugs or optically active intermediates is highly desired in many fields like medicine, food and biochemistry. Thereby, it also promoted the development of various enantiomer selective separation techniques. Among the many chiral separation methods, chiral mobile phase additives(CMPAs) are widely used in various chromatographic techniques due to their simple operation,good versatility and low price. There have been a number of reviews on the research progress of CMPAs in last 2 decades,but they only reviewed the application of CMPAs in one specific chromatographic technique. Therefore, to provide a more comprehensive illustration of CMPAs in separation technology, their applications in high-performance liquid chromatography, capillary electrophoresis, countercurrent chromatography, nano-liquid chromatography were summarized and their advantages and disadvantages were briefly introduced in this critical review. The application of molecular simulation in the study of chiral separation mechanism was briefly summarized. We expect that it will provide researchers with the latest developments in this field and potential inspirations. 展开更多
关键词 Chiral mobile phase additives High-performance liquid chromatography(HPLC) Capillary electrophoresis(CE) Countercurrent chromatography(CCC) Nano-liquid chromatography(Nano-LC)
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Enantiomeric separations of four basic drugs containing N-alkyl groups by a RP-HPLC system using SBE-β-CD as chiral mobile phase additive 被引量:2
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作者 Min Huang Wen-Jing Chen +11 位作者 Ying Zhou Ru Feng Jie Fu Jing-Yi Ma Xiang-Shan Tan Chi-Yu He Qi-Ming Zhang Wen-Yi He Yu-Lin Deng Yu-Kui Zhang Xian-Feng Zhang Yan Wang 《Chinese Chemical Letters》 SCIE CAS CSCD 2013年第9期840-844,共5页
The chiral separations of four pharmaceutical racemates which contain N-alkyl groups were satisfactorily resolved using SBE-β-CD as a chiral mobile phase additive (CMPA) in a RP-HPLC system (the resolution is 2.70... The chiral separations of four pharmaceutical racemates which contain N-alkyl groups were satisfactorily resolved using SBE-β-CD as a chiral mobile phase additive (CMPA) in a RP-HPLC system (the resolution is 2.701 for ondansetron hydrochloride, 1.996 for sulpiride, 1.293 for clenbuterol hydrochloride and 0.816 for omeprazole). In addition, the effects of different parameters such as CD type and CD concentration were investigated. The separation mechanism arises through the combination of several potential interactions, including electrostatic interactions as well as hydrogen bonding interactions and hydrophobic inclusion interactions, which allow for the SBE-β-CD-drug complexation with strong stereoselectivity and stability. The resolution also relates to the number and location of N atoms in the enantiomers. This method will be applicable to the isolation of various types of biologically imoortant enantiomers containing N-alkyl groups. 展开更多
关键词 Chiral separation Chiral mobile phase additive (CMPA)SBE-β-CDN-Alkyl group
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Novel additives for the separation of organic acids by ion-pair chromatography
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作者 Zhong, Ying Ying Zhou, Wen Fang +2 位作者 Hu, Zhen Zhen Chen, Mei Lan Zhu, Yan 《Chinese Chemical Letters》 SCIE CAS CSCD 2010年第4期453-456,共4页
This paper proposes the use of novel surfactant additives for the separation of organic acids by ion-pair chromatography and studies the influences of surfactants on the chromatographic separation behaviors.Researches... This paper proposes the use of novel surfactant additives for the separation of organic acids by ion-pair chromatography and studies the influences of surfactants on the chromatographic separation behaviors.Researches have been carried out on both silica gel matrix and polymer supporters in order to compare the two ordinary kinds of stationary phases,and the phenomenon is similar. Separation is based on differences in the stabilities of analyte-additive complexes in solution.Retention times of analytes can ... 展开更多
关键词 Organic acids Ion-pair chromatography SURFACTANT mobile phase additives
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