The robust magnesium surfaces with multi-functions are highly desirable,and the simple and scalable methods to construct such surfaces are urgently indispensable.Herein,we conducted a one-step spraying method to facil...The robust magnesium surfaces with multi-functions are highly desirable,and the simple and scalable methods to construct such surfaces are urgently indispensable.Herein,we conducted a one-step spraying method to facilely fabricate the robust coating with multi-functions on magnesium alloys.The as-sprayed magnesium alloys surface is superhydrophobic with a static water contact angle(WCA)of 157.0°and a roll-off angle of 6.0°.Such surface has excellent mechanical,chemical and thermal stabilities,even undergoing various physical and chemical damages,including sand impact(10 gmin^(-1),≥20 min),water impact(2 impacts s^(-1),≥180 min),abrasion(1.00 kPa,≥25 cycles),peeling(≥2.15 kPa),high temperature(200°C,≥24 h),strong acidic/salty/basic media(p H=113)and organic-solvent immersion(ethanol and n-hexane,≥24 h),demonstrating brilliant robustness.Notably,the surface displays multi-functions of corrosion protection,anti-fouling and heat insulation,which will undoubtedly promote the much wider applications of magnesium alloys.展开更多
Fiber-shaped supercapacitors(FSSCs)show great potential in portable and wearable electronics due to their unique advantages of high safety,environmental friendliness,high performances,outstanding flexibility and integ...Fiber-shaped supercapacitors(FSSCs)show great potential in portable and wearable electronics due to their unique advantages of high safety,environmental friendliness,high performances,outstanding flexibility and integrability.They can directly act as the power sources or be easily integrated with other flexible devices to constitute self-powered and sustainable energy suppliers,providing excellent adaptability to irregular surfaces.This review mainly summarizes the recently reported works of FSSCs including preparation methods of various fiber electrodes,construction strategies of FSSCs and multi-functional device integrations,exploration of reaction mechanisms and strategies to improve the electrochemical performance and provision of suggestions on further designing and optimization of FSSCs.Meanwhile,it shares our perspectives on challenges and opportunities in this field,shedding light on the development of high-performance fiber-shaped supercapacitors with multifunctions.展开更多
With the increasing demand for scalable and cost-effective electrochemical energy storage,aqueous zinc ion batteries(AZIBs)have a broad application prospect as an inexpensive,efficient,and naturally secure energy stor...With the increasing demand for scalable and cost-effective electrochemical energy storage,aqueous zinc ion batteries(AZIBs)have a broad application prospect as an inexpensive,efficient,and naturally secure energy storage device.However,the limitations suffered by AZIBs,including volume expansion and active materials dissolution of the cathode,electrochemical corrosion,irreversible side reactions,zinc dendrites of the anode,have seriously decelerated the civilianization process of AZIBs.Currently,polymers have tremendous superiority for application in AZIBs attributed to their exceptional chemical stability,tunable structure,high energy density and outstanding mechanical properties.Considering the expanding applications of AZIBs and the superiority of polymers,this comprehensive paper meticulously reviews the benefits of utilizing polymeric applied to cathodes and anodes,respectively.To begin with,with adjustable structure as an entry point,the correlation between polymer structure and the function of energy storage as well as optimization is deeply investigated in respect to the mechanism.Then,depending on the diversity of properties and structures,the development of polymers in AZIBs is summarized,including conductive polymers,redox polymers as well as carbon composite polymers for cathode and polyvinylidene fluoride-,carbonyl-,amino-,nitrile-based polymers for anode,and a comprehensive evaluation of the shortcomings of these strategies is provided.Finally,an outlook highlights some of the challenges posed by the application of polymers and offers insights into the potential future direction of polymers in AZIBs.It is designed to provide a thorough reference for researchers and developers working on polymer for AZIBs.展开更多
To fulfill the demands for higher quality,efficiency and flexibility in aviation industry,a multi-functional end effector is designed to automate the drilling and riveting processes in assembling carbon fiber reinforc...To fulfill the demands for higher quality,efficiency and flexibility in aviation industry,a multi-functional end effector is designed to automate the drilling and riveting processes in assembling carbon fiber reinforced polymer(CFRP)and aluminum components for a robotic aircraft assembly system.To meet the specific functional requirements for blind rivet installation on CFRP and aluminum materials,additional modules are incorporated on the end effector aside of the basic processing modules for drilling.And all of these processing modules allow for a onestep-drilling-countersinking process,hole inspection,automatic rivet feed,rivet geometry check,sealant application,rivet insertion and installation.Besides,to guarantee the better quality of the hole drilled and joints riveted,several online detection and adjustment measures are applied to this end effector,including the reference detection and perpendicular calibration,which could effectively ensure the positioning precision and perpendicular accuracy as demanded.Finally,the test result shows that this end effector is capable of producing each hole to a positioning precision within ±0.5 mm,aperpendicular accuracy within 0.3°,a diameter tolerance of H8,and a countersink depth tolerance of±0.01 mm.Moreover,it could drill and rivet up to three joints per minute,with acceptable shearing and tensile strength.展开更多
Folate receptor(FR)overexpression occurs in a variety of cancers,including pancreatic cancer.In addition,enhanced macropinocytosis exists in K-Ras mutant pancreatic cancer.Furthermore,the occurrence of intensive desmo...Folate receptor(FR)overexpression occurs in a variety of cancers,including pancreatic cancer.In addition,enhanced macropinocytosis exists in K-Ras mutant pancreatic cancer.Furthermore,the occurrence of intensive desmoplasia causes a hypoxic microenvironment in pancreatic cancer.In this study,a novel FR-directed,macropinocytosis-enhanced,and highly cytotoxic bioconjugate folate(F)-human serum albumin(HSA)-apoprotein of lidamycin(LDP)-active enediyne(AE)derived from lidamycin was designed and prepared.F-HSA-LDP-AE consisted of four moieties:F,HSA,LDP,and AE.F-HSA-LDP presented high binding efficiency with the FR and pancreatic cancer cells.Its uptake in wild-type cells was more extensive than in K-Ras mutant-type cells.By in vivo optical imaging,F-HSA-LDP displayed prominent tumor-specific biodistribution in pancreatic cancer xenograft-bearing mice,showing clear and lasting tumor localization for 360 h.In the MTT assay,F-HSA-LDP-AE demonstrated potent cytotoxicity in three types of pancreatic cancer cell lines.It also induced apoptosis and caused G2/M cell cycle arrest.F-HSALDP-AE markedly suppressed the tumor growth of AsPc-1 pancreatic cancer xenografts in athymic mice.At well-tolerated doses of 0.5 and 1 mg/kg,(i.v.,twice),the inhibition rates were 91.2%and 94.8%,respectively(P<0.01).The results of this study indicate that the F-HSA-LDP multi-functional bioconjugate might be effective for treating K-Ras mutant pancreatic cancer.展开更多
We propose a novel and efficient multi-functional optical fiber sensor system based on a dense wavelength division multiplexer(DWDM).This system consists of an optical fiber temperature sensor, an optical fiber strain...We propose a novel and efficient multi-functional optical fiber sensor system based on a dense wavelength division multiplexer(DWDM).This system consists of an optical fiber temperature sensor, an optical fiber strain sensor, and a 48-channel DWDM.This system can monitor temperature and strain changes at the same time.The ranges of these two sensors are from-20℃ to 100℃ and from-1000 με to 2000 με, respectively.The sensitivities of the temperature sensor and strain sensor are 0.03572 nm/℃ and 0.03808 nm/N, respectively.With the aid of a broadband source and spectrometer,different kinds and ranges of parameters in the environment can be monitored by using suitable sensors.展开更多
In order to meet increasing demand for higher productivity and flexibility, recently many kinds of multi-functional machine tools, which are capable of multiple machining functions or different kinds of machining proc...In order to meet increasing demand for higher productivity and flexibility, recently many kinds of multi-functional machine tools, which are capable of multiple machining functions or different kinds of machining processes on one machine, have been developed and widely used in manufacturing industries. In this study, a multi-functional turning lathe, which has two spindles and two turrets so that multiple turning operations and various machining processes could be performed simultaneously, has been developed. Furthermore, the equations of correlation between whole responses and cross responses of the two spindles have been derived to examine to what extent the two spindles affect each other’s vibrations.展开更多
We demonstrate a fiber-loop ring down multi-function sensors system, which can be used to measure refractive index and curvature simultaneously. Good agreement has been found between theoretical analyses and experimen...We demonstrate a fiber-loop ring down multi-function sensors system, which can be used to measure refractive index and curvature simultaneously. Good agreement has been found between theoretical analyses and experimental results. It has great potential for sensor applications.展开更多
This study presents a design of a multifunctional laparoscopic appendectomy device that includes three surgical instruments commonly used in laparoscopic appendicitis surgeries:endoloop,endobag and scissors.It collect...This study presents a design of a multifunctional laparoscopic appendectomy device that includes three surgical instruments commonly used in laparoscopic appendicitis surgeries:endoloop,endobag and scissors.It collects these three independent surgical tools in a single laparoscopic appendectomy device.These days there is a trend of moving to multi-functional surgery devices during minimally invasive surgery.The main reasons behind the minimal invasive surgery are to avoid changing the devices several times during the operation,to reduce the time spent in operation,to increase the efficiency of the operation,to facilitate the follow-up of the camera and devices,and to leave trocars to be used for other surgical instruments.The multi-functional appendectomy device that,we present here,provides these benefits.The standard trocar entries are appropriate for its usage.The presented multifunctional laparoscopic appendectomy device offers more practical use in comparison to individual devices.On the other hand,development of these multi-functional surgery devices can be directly enhanced to the robotic surgery devices.展开更多
The paper intfoduces a PC-DSP based real-time digital simulator which is portable in size and aimed at the closed-loop testing of various types of protective relays for their design and application. The simulator can ...The paper intfoduces a PC-DSP based real-time digital simulator which is portable in size and aimed at the closed-loop testing of various types of protective relays for their design and application. The simulator can be widely used in not only concerning utilities but also manufacturers and research / certification institutes because of its many functions. The hardware architecture and software implementation of the simulator are described. The main features and functions of the simulator are also展开更多
Timbre,as one of the essential elements of sound,plays an important role in determining sound properties,whereas its manipulation has been remaining challenging for passive mechanical systems due to the intrinsic disp...Timbre,as one of the essential elements of sound,plays an important role in determining sound properties,whereas its manipulation has been remaining challenging for passive mechanical systems due to the intrinsic dispersion nature of resonances.Here,we present a meta-silencer supporting intensive mode density as well as highly tunable intrinsic loss and offering a fresh pathway for designable timbre in broadband.Strong global coupling is induced by intensive mode density and delicately modulated with the guidance of the theoretical model,which efficiently suppresses the resonance dispersion and provides desirable frequency-selective wave-manipulation capacity for timbre tuning.As proof-of-concept demonstrations for our design concepts,we propose three meta-silencers with the designing targets of high-efficiency broadband sound attenuation,efficiency-controlled sound attenuation and designable timbre,respectively.The proposed meta-silencers all operate in a broadband frequency range from 500 to 3200 Hz and feature deep-subwavelength sizes around 50 mm.Our work opens up a fundamental avenue to manipulate the timbre with passive resonances-controlled acoustic metamaterials and may inspire the development of novel multifunctional devices in noise-control engineering,impedance engineering,and architectural acoustics.展开更多
In the complex countermeasure environment,the pulse description words(PDWs)of the same type of multi-function radar emitters are similar in multiple dimensions.Therefore,it is difficult for conventional methods to dei...In the complex countermeasure environment,the pulse description words(PDWs)of the same type of multi-function radar emitters are similar in multiple dimensions.Therefore,it is difficult for conventional methods to deinterleave such emitters.In order to solve this problem,a pulse deinterleaving method based on implicit features is proposed in this paper.The proposed method introduces long short-term memory(LSTM)neural networks and statistical analysis to mine new features from similar PDW features,that is,the variation law(implicit features)of pulse sequences of different radiation sources over time.The multi-function radar emitter is deinterleaved based on the pulse sequence variation law.Statistical results show that the proposed method not only achieves satisfactory performance,but also has good robustness.展开更多
With the development of medical level, specialized, refined and multidisciplinary collaborative therapy is the requirement and main development direction of neurosurgery. With the improvement of people’s medical awar...With the development of medical level, specialized, refined and multidisciplinary collaborative therapy is the requirement and main development direction of neurosurgery. With the improvement of people’s medical awareness, people cannot meet the simple surgical treatment, and there is a great demand for nursing treatment. At the same time, the demand for efficiency and convenience of medical nursing practice teaching continues to improve, and the multi-functional medical nursing training innovation platform has been paid more and more attention. The rapid development of material technology as well as digitalization has brought about a huge change, and we have created a multifunctional, spatially efficient and easy-to-transfer information platform for medical care training. A base box, placement drawer, platform board and display are used as the base module and the base module is filled with specific functional components. Lifting and lowering using motors and spiral base, moving using universal wheels. These devices together constitute the training platform. A survey of students and teachers was conducted through a questionnaire, and they all gave very good feedback that the multi-functional platform was very practical and useful. This platform effectively solves the drawbacks of the original training platform which is time-consuming, laborious and inconvenient, and is worthy of further promotion and research.展开更多
According to the investigation and study on the land use of different cemeteries in rural areas,the intensive land use of four cemeteries,including the public cemetery,traditional cemetery,vertical cemetery,and ecolog...According to the investigation and study on the land use of different cemeteries in rural areas,the intensive land use of four cemeteries,including the public cemetery,traditional cemetery,vertical cemetery,and ecological cemetery,was evaluated.According to the data analysis,it is suggested to choose right cemetery according the practical conditions of each area,to take full use the multiple functions of cemetery lands and improve the intensive use.展开更多
Eco-friendly electromagnetic wave absorbing materials with excellent thermal infrared stealth property,heat-insulating ability and compression resistance are highly attractive in practical applications.Meeting the afo...Eco-friendly electromagnetic wave absorbing materials with excellent thermal infrared stealth property,heat-insulating ability and compression resistance are highly attractive in practical applications.Meeting the aforesaid requirements simultaneously is a formidable challenge.Herein,ultra-light carbon aerogels were fabricated via fresh shaddock peel by facile freeze-drying method and calcination process,forming porous network architecture.With the heating platform temperature of 70℃,the upper surface temperatures of the as-prepared carbon aerogel present a slow upward trend.The color of the sample surface in thermal infrared images is similar to that of the surroundings.With the maximum compressive stress of 2.435 kPa,the carbon aerogels can provide favorable endurance.The shaddock peel-based carbon aerogels possess the minimum reflection loss value(RLmin)of−29.50 dB in X band.Meanwhile,the effective absorption bandwidth covers 5.80 GHz at a relatively thin thickness of only 1.7 mm.With the detection theta of 0°,the maximum radar cross-sectional(RCS)reduction values of 16.28 dB m^(2) can be achieved.Theoretical simulations of RCS have aroused extensive interest owing to their ingenious design and time-saving feature.This work paves the way for preparing multi-functional microwave absorbers derived from biomass raw materials under the guidance of RCS simulations.展开更多
Background: Forest ecosystems are increasingly seen as multi-functional production systems, which should provide,besides timber and economic benefits, also other ecosystem services related to biological diversity, rec...Background: Forest ecosystems are increasingly seen as multi-functional production systems, which should provide,besides timber and economic benefits, also other ecosystem services related to biological diversity, recreational uses and environmental functions of forests. This study analyzed the performance of even-aged rotation forest management(RFM)continuous cover forestry(CCF) and any-aged forestry(AAF) in the production of ecosystem services. AAF al ows both even-aged and uneven-aged management schedules. The ecosystem services included in the analyses were net present value, volume of harvested timber, cowberry and bilberry yields, scenic value of the forest, carbon balance and suitability of the forest to Siberian jay.Methods: Data envelopment analysis was used to derive numerical efficiency ratios for the three management systems.Efficiency ratio is the sum of weighted outputs(ecosystem services) divided by the sum of weighted inputs. The linear programing model proposed by Charnes, Cooper and Rhodes was used to derive the weights for calculating efficiency scores for the silvicultural systems.Results and conclusions: CCF provided more ecosystem services than RFM, and CCF was more efficient than RFM and AAF in the production of ecosystem services. Multi-objective management provided more ecosystem services(except harvested timber) than single-objective management that maximized economic profitability. The use of low discount rate(resulting in low cutting level and high growing stock volume) led to better supply of most ecosystems services than the use of high discount rate. RFM where NPV was maximized with high discount rate led to particularly poor provision of most ecosystem services. In CCF the provision of ecosystem services was less sensitive to changes in discount rate and management objective than in RFM.展开更多
In most multi-function phased array radar applications,multiple missions, including airspace searching and target tracking,are usually performed simultaneously by the digital beam-forming technique and the time dividi...In most multi-function phased array radar applications,multiple missions, including airspace searching and target tracking,are usually performed simultaneously by the digital beam-forming technique and the time dividing method. This paper presents a novel method to classify pulses of different missions from an interleaved pulse sequence emitted by the same radar, which is significant in radar electronic reconnaissance and electronic support measure. Firstly, two hypotheses, i.e., pulse relativity within the same mission and pulse independence among different missions, are proposed by analyzing the antenna pattern and the beam scheduling method of the phased array radar. Based on the above two hypotheses, an optimal model for pulse classification is exploited with pulse amplitude series, where the absolute-value sum of second order difference is taken as the optimal kernel to measure sequence smooth continuity. Finally, several pieces of sequences under different numbers of missions and tracking data rates are simulated for algorithm verification. The simulation results show that the long data length and the high data rate will increase classification efficiency due to the validity of the two hypotheses in sufficient pulse amplitude sequence.展开更多
A liquid metal reactor(LMR) loaded with a fuel compound of uranium and beryllium(U-Be alloy fuel),which was cooled by a lead-bismuth eutectic alloy(PbBi),has been applied in Russian Alfa-class nuclear submarines.Becau...A liquid metal reactor(LMR) loaded with a fuel compound of uranium and beryllium(U-Be alloy fuel),which was cooled by a lead-bismuth eutectic alloy(PbBi),has been applied in Russian Alfa-class nuclear submarines.Because of the large amount of beryllium in the core, the reaction between the beryllium atoms and neutrons could result in the accumulation of 3 He and 6 Li, which are called the "poisoned elements" owing to their large thermal neutron capture cross section. The accumulation of neutron absorber can affect the performance of a reactor. In this study, the Super Multi-functional Calculation Program(SuperMC) code, which was developed by Institute of Nuclear Energy Safety Technology of the Chinese Academy of Sciences(INEST, CAS), was adopted to illustrate the influence of beryllium on an LMR.展开更多
基金supported by the National Natural Science Foundation of China(21773019,21972012)the Graduate Research and Innovation Foundation of Chongqing(CYB18044)the sharing fund of Chongqing University s Large-scale Equipment
文摘The robust magnesium surfaces with multi-functions are highly desirable,and the simple and scalable methods to construct such surfaces are urgently indispensable.Herein,we conducted a one-step spraying method to facilely fabricate the robust coating with multi-functions on magnesium alloys.The as-sprayed magnesium alloys surface is superhydrophobic with a static water contact angle(WCA)of 157.0°and a roll-off angle of 6.0°.Such surface has excellent mechanical,chemical and thermal stabilities,even undergoing various physical and chemical damages,including sand impact(10 gmin^(-1),≥20 min),water impact(2 impacts s^(-1),≥180 min),abrasion(1.00 kPa,≥25 cycles),peeling(≥2.15 kPa),high temperature(200°C,≥24 h),strong acidic/salty/basic media(p H=113)and organic-solvent immersion(ethanol and n-hexane,≥24 h),demonstrating brilliant robustness.Notably,the surface displays multi-functions of corrosion protection,anti-fouling and heat insulation,which will undoubtedly promote the much wider applications of magnesium alloys.
基金upported by the National Natural Science Foundation of China(No.21875226)the Science Fund for Distinguished Young Scholars of Sichuan Province(No.2017JQ0036)the Chengdu Rongpiao Talent plan,the Sichuan'Ten-thousand Talents Program",the"QianYingBaiTuan"Plan of China Mianyang Science City,the Science Foundation of Institute of Chemical Materials(No.O11100301)the"Global Experts Recruitment"program.
文摘Fiber-shaped supercapacitors(FSSCs)show great potential in portable and wearable electronics due to their unique advantages of high safety,environmental friendliness,high performances,outstanding flexibility and integrability.They can directly act as the power sources or be easily integrated with other flexible devices to constitute self-powered and sustainable energy suppliers,providing excellent adaptability to irregular surfaces.This review mainly summarizes the recently reported works of FSSCs including preparation methods of various fiber electrodes,construction strategies of FSSCs and multi-functional device integrations,exploration of reaction mechanisms and strategies to improve the electrochemical performance and provision of suggestions on further designing and optimization of FSSCs.Meanwhile,it shares our perspectives on challenges and opportunities in this field,shedding light on the development of high-performance fiber-shaped supercapacitors with multifunctions.
基金financially supported by the National Natural Science Foundation of China(51872090,51772097,22304055)the Hebei Natural Science Fund for Distinguished Young Scholar(E2019209433)+4 种基金the Youth Talent Program of Hebei Provincial Education Department(BJ2018020)the Natural Science Foundation of Hebei Province(E2020209151,E2022209158,B2022209026,D2023209012)the Central Guiding Local Science and Technology Development Fund Project(236Z4409G)the Science and Technology Project of Hebei Education Department(SLRC2019028)the Science and Technology Planning Project of Tangshan City(22130227H)。
文摘With the increasing demand for scalable and cost-effective electrochemical energy storage,aqueous zinc ion batteries(AZIBs)have a broad application prospect as an inexpensive,efficient,and naturally secure energy storage device.However,the limitations suffered by AZIBs,including volume expansion and active materials dissolution of the cathode,electrochemical corrosion,irreversible side reactions,zinc dendrites of the anode,have seriously decelerated the civilianization process of AZIBs.Currently,polymers have tremendous superiority for application in AZIBs attributed to their exceptional chemical stability,tunable structure,high energy density and outstanding mechanical properties.Considering the expanding applications of AZIBs and the superiority of polymers,this comprehensive paper meticulously reviews the benefits of utilizing polymeric applied to cathodes and anodes,respectively.To begin with,with adjustable structure as an entry point,the correlation between polymer structure and the function of energy storage as well as optimization is deeply investigated in respect to the mechanism.Then,depending on the diversity of properties and structures,the development of polymers in AZIBs is summarized,including conductive polymers,redox polymers as well as carbon composite polymers for cathode and polyvinylidene fluoride-,carbonyl-,amino-,nitrile-based polymers for anode,and a comprehensive evaluation of the shortcomings of these strategies is provided.Finally,an outlook highlights some of the challenges posed by the application of polymers and offers insights into the potential future direction of polymers in AZIBs.It is designed to provide a thorough reference for researchers and developers working on polymer for AZIBs.
基金supported by the National Natural Science Foundations of China(Nos.5157051626,51475225)
文摘To fulfill the demands for higher quality,efficiency and flexibility in aviation industry,a multi-functional end effector is designed to automate the drilling and riveting processes in assembling carbon fiber reinforced polymer(CFRP)and aluminum components for a robotic aircraft assembly system.To meet the specific functional requirements for blind rivet installation on CFRP and aluminum materials,additional modules are incorporated on the end effector aside of the basic processing modules for drilling.And all of these processing modules allow for a onestep-drilling-countersinking process,hole inspection,automatic rivet feed,rivet geometry check,sealant application,rivet insertion and installation.Besides,to guarantee the better quality of the hole drilled and joints riveted,several online detection and adjustment measures are applied to this end effector,including the reference detection and perpendicular calibration,which could effectively ensure the positioning precision and perpendicular accuracy as demanded.Finally,the test result shows that this end effector is capable of producing each hole to a positioning precision within ±0.5 mm,aperpendicular accuracy within 0.3°,a diameter tolerance of H8,and a countersink depth tolerance of±0.01 mm.Moreover,it could drill and rivet up to three joints per minute,with acceptable shearing and tensile strength.
基金supported by grants from CAMS Innovation Fund for Medical Sciences(Grant No.:2021-I2M-1-026)Scientific Research Project of Tianjin Education Commission(Grant No.:2020KJ140)Tianjin Health Research Project(Grant No.:KJ20017)。
文摘Folate receptor(FR)overexpression occurs in a variety of cancers,including pancreatic cancer.In addition,enhanced macropinocytosis exists in K-Ras mutant pancreatic cancer.Furthermore,the occurrence of intensive desmoplasia causes a hypoxic microenvironment in pancreatic cancer.In this study,a novel FR-directed,macropinocytosis-enhanced,and highly cytotoxic bioconjugate folate(F)-human serum albumin(HSA)-apoprotein of lidamycin(LDP)-active enediyne(AE)derived from lidamycin was designed and prepared.F-HSA-LDP-AE consisted of four moieties:F,HSA,LDP,and AE.F-HSA-LDP presented high binding efficiency with the FR and pancreatic cancer cells.Its uptake in wild-type cells was more extensive than in K-Ras mutant-type cells.By in vivo optical imaging,F-HSA-LDP displayed prominent tumor-specific biodistribution in pancreatic cancer xenograft-bearing mice,showing clear and lasting tumor localization for 360 h.In the MTT assay,F-HSA-LDP-AE demonstrated potent cytotoxicity in three types of pancreatic cancer cell lines.It also induced apoptosis and caused G2/M cell cycle arrest.F-HSALDP-AE markedly suppressed the tumor growth of AsPc-1 pancreatic cancer xenografts in athymic mice.At well-tolerated doses of 0.5 and 1 mg/kg,(i.v.,twice),the inhibition rates were 91.2%and 94.8%,respectively(P<0.01).The results of this study indicate that the F-HSA-LDP multi-functional bioconjugate might be effective for treating K-Ras mutant pancreatic cancer.
基金Project supported by the National Key Research and Development Program of China(Grant No.2016YFB0402504)the National Natural Science Foundation of China(Grant Nos.61875069 and 61575076)+1 种基金Hong Kong Scholars Program,China(Grant No.XJ2016026)the Science and Technology Development Plan of Jilin Province,China(Grant Nos.20190302010GX and 20160520091JH)
文摘We propose a novel and efficient multi-functional optical fiber sensor system based on a dense wavelength division multiplexer(DWDM).This system consists of an optical fiber temperature sensor, an optical fiber strain sensor, and a 48-channel DWDM.This system can monitor temperature and strain changes at the same time.The ranges of these two sensors are from-20℃ to 100℃ and from-1000 με to 2000 με, respectively.The sensitivities of the temperature sensor and strain sensor are 0.03572 nm/℃ and 0.03808 nm/N, respectively.With the aid of a broadband source and spectrometer,different kinds and ranges of parameters in the environment can be monitored by using suitable sensors.
文摘In order to meet increasing demand for higher productivity and flexibility, recently many kinds of multi-functional machine tools, which are capable of multiple machining functions or different kinds of machining processes on one machine, have been developed and widely used in manufacturing industries. In this study, a multi-functional turning lathe, which has two spindles and two turrets so that multiple turning operations and various machining processes could be performed simultaneously, has been developed. Furthermore, the equations of correlation between whole responses and cross responses of the two spindles have been derived to examine to what extent the two spindles affect each other’s vibrations.
文摘We demonstrate a fiber-loop ring down multi-function sensors system, which can be used to measure refractive index and curvature simultaneously. Good agreement has been found between theoretical analyses and experimental results. It has great potential for sensor applications.
文摘This study presents a design of a multifunctional laparoscopic appendectomy device that includes three surgical instruments commonly used in laparoscopic appendicitis surgeries:endoloop,endobag and scissors.It collects these three independent surgical tools in a single laparoscopic appendectomy device.These days there is a trend of moving to multi-functional surgery devices during minimally invasive surgery.The main reasons behind the minimal invasive surgery are to avoid changing the devices several times during the operation,to reduce the time spent in operation,to increase the efficiency of the operation,to facilitate the follow-up of the camera and devices,and to leave trocars to be used for other surgical instruments.The multi-functional appendectomy device that,we present here,provides these benefits.The standard trocar entries are appropriate for its usage.The presented multifunctional laparoscopic appendectomy device offers more practical use in comparison to individual devices.On the other hand,development of these multi-functional surgery devices can be directly enhanced to the robotic surgery devices.
文摘The paper intfoduces a PC-DSP based real-time digital simulator which is portable in size and aimed at the closed-loop testing of various types of protective relays for their design and application. The simulator can be widely used in not only concerning utilities but also manufacturers and research / certification institutes because of its many functions. The hardware architecture and software implementation of the simulator are described. The main features and functions of the simulator are also
文摘Timbre,as one of the essential elements of sound,plays an important role in determining sound properties,whereas its manipulation has been remaining challenging for passive mechanical systems due to the intrinsic dispersion nature of resonances.Here,we present a meta-silencer supporting intensive mode density as well as highly tunable intrinsic loss and offering a fresh pathway for designable timbre in broadband.Strong global coupling is induced by intensive mode density and delicately modulated with the guidance of the theoretical model,which efficiently suppresses the resonance dispersion and provides desirable frequency-selective wave-manipulation capacity for timbre tuning.As proof-of-concept demonstrations for our design concepts,we propose three meta-silencers with the designing targets of high-efficiency broadband sound attenuation,efficiency-controlled sound attenuation and designable timbre,respectively.The proposed meta-silencers all operate in a broadband frequency range from 500 to 3200 Hz and feature deep-subwavelength sizes around 50 mm.Our work opens up a fundamental avenue to manipulate the timbre with passive resonances-controlled acoustic metamaterials and may inspire the development of novel multifunctional devices in noise-control engineering,impedance engineering,and architectural acoustics.
基金the National Major Research&Development project of China(2018YFE0206500)the National Natural Science Foundation of China(62071140)+1 种基金the Program of China International Scientific and Technological Cooperation(2015DFR10220)the Technology Foundation for Basic Enhancement Plan(2021-JCJQ-JJ-0301).
文摘In the complex countermeasure environment,the pulse description words(PDWs)of the same type of multi-function radar emitters are similar in multiple dimensions.Therefore,it is difficult for conventional methods to deinterleave such emitters.In order to solve this problem,a pulse deinterleaving method based on implicit features is proposed in this paper.The proposed method introduces long short-term memory(LSTM)neural networks and statistical analysis to mine new features from similar PDW features,that is,the variation law(implicit features)of pulse sequences of different radiation sources over time.The multi-function radar emitter is deinterleaved based on the pulse sequence variation law.Statistical results show that the proposed method not only achieves satisfactory performance,but also has good robustness.
文摘With the development of medical level, specialized, refined and multidisciplinary collaborative therapy is the requirement and main development direction of neurosurgery. With the improvement of people’s medical awareness, people cannot meet the simple surgical treatment, and there is a great demand for nursing treatment. At the same time, the demand for efficiency and convenience of medical nursing practice teaching continues to improve, and the multi-functional medical nursing training innovation platform has been paid more and more attention. The rapid development of material technology as well as digitalization has brought about a huge change, and we have created a multifunctional, spatially efficient and easy-to-transfer information platform for medical care training. A base box, placement drawer, platform board and display are used as the base module and the base module is filled with specific functional components. Lifting and lowering using motors and spiral base, moving using universal wheels. These devices together constitute the training platform. A survey of students and teachers was conducted through a questionnaire, and they all gave very good feedback that the multi-functional platform was very practical and useful. This platform effectively solves the drawbacks of the original training platform which is time-consuming, laborious and inconvenient, and is worthy of further promotion and research.
文摘According to the investigation and study on the land use of different cemeteries in rural areas,the intensive land use of four cemeteries,including the public cemetery,traditional cemetery,vertical cemetery,and ecological cemetery,was evaluated.According to the data analysis,it is suggested to choose right cemetery according the practical conditions of each area,to take full use the multiple functions of cemetery lands and improve the intensive use.
基金National Nature Science Foundation of China(No.51971111)Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX20_0190).
文摘Eco-friendly electromagnetic wave absorbing materials with excellent thermal infrared stealth property,heat-insulating ability and compression resistance are highly attractive in practical applications.Meeting the aforesaid requirements simultaneously is a formidable challenge.Herein,ultra-light carbon aerogels were fabricated via fresh shaddock peel by facile freeze-drying method and calcination process,forming porous network architecture.With the heating platform temperature of 70℃,the upper surface temperatures of the as-prepared carbon aerogel present a slow upward trend.The color of the sample surface in thermal infrared images is similar to that of the surroundings.With the maximum compressive stress of 2.435 kPa,the carbon aerogels can provide favorable endurance.The shaddock peel-based carbon aerogels possess the minimum reflection loss value(RLmin)of−29.50 dB in X band.Meanwhile,the effective absorption bandwidth covers 5.80 GHz at a relatively thin thickness of only 1.7 mm.With the detection theta of 0°,the maximum radar cross-sectional(RCS)reduction values of 16.28 dB m^(2) can be achieved.Theoretical simulations of RCS have aroused extensive interest owing to their ingenious design and time-saving feature.This work paves the way for preparing multi-functional microwave absorbers derived from biomass raw materials under the guidance of RCS simulations.
文摘Background: Forest ecosystems are increasingly seen as multi-functional production systems, which should provide,besides timber and economic benefits, also other ecosystem services related to biological diversity, recreational uses and environmental functions of forests. This study analyzed the performance of even-aged rotation forest management(RFM)continuous cover forestry(CCF) and any-aged forestry(AAF) in the production of ecosystem services. AAF al ows both even-aged and uneven-aged management schedules. The ecosystem services included in the analyses were net present value, volume of harvested timber, cowberry and bilberry yields, scenic value of the forest, carbon balance and suitability of the forest to Siberian jay.Methods: Data envelopment analysis was used to derive numerical efficiency ratios for the three management systems.Efficiency ratio is the sum of weighted outputs(ecosystem services) divided by the sum of weighted inputs. The linear programing model proposed by Charnes, Cooper and Rhodes was used to derive the weights for calculating efficiency scores for the silvicultural systems.Results and conclusions: CCF provided more ecosystem services than RFM, and CCF was more efficient than RFM and AAF in the production of ecosystem services. Multi-objective management provided more ecosystem services(except harvested timber) than single-objective management that maximized economic profitability. The use of low discount rate(resulting in low cutting level and high growing stock volume) led to better supply of most ecosystems services than the use of high discount rate. RFM where NPV was maximized with high discount rate led to particularly poor provision of most ecosystem services. In CCF the provision of ecosystem services was less sensitive to changes in discount rate and management objective than in RFM.
文摘In most multi-function phased array radar applications,multiple missions, including airspace searching and target tracking,are usually performed simultaneously by the digital beam-forming technique and the time dividing method. This paper presents a novel method to classify pulses of different missions from an interleaved pulse sequence emitted by the same radar, which is significant in radar electronic reconnaissance and electronic support measure. Firstly, two hypotheses, i.e., pulse relativity within the same mission and pulse independence among different missions, are proposed by analyzing the antenna pattern and the beam scheduling method of the phased array radar. Based on the above two hypotheses, an optimal model for pulse classification is exploited with pulse amplitude series, where the absolute-value sum of second order difference is taken as the optimal kernel to measure sequence smooth continuity. Finally, several pieces of sequences under different numbers of missions and tracking data rates are simulated for algorithm verification. The simulation results show that the long data length and the high data rate will increase classification efficiency due to the validity of the two hypotheses in sufficient pulse amplitude sequence.
基金supported by the Natural Science Foundation of Anhui Province of China(No.1608085ME107)
文摘A liquid metal reactor(LMR) loaded with a fuel compound of uranium and beryllium(U-Be alloy fuel),which was cooled by a lead-bismuth eutectic alloy(PbBi),has been applied in Russian Alfa-class nuclear submarines.Because of the large amount of beryllium in the core, the reaction between the beryllium atoms and neutrons could result in the accumulation of 3 He and 6 Li, which are called the "poisoned elements" owing to their large thermal neutron capture cross section. The accumulation of neutron absorber can affect the performance of a reactor. In this study, the Super Multi-functional Calculation Program(SuperMC) code, which was developed by Institute of Nuclear Energy Safety Technology of the Chinese Academy of Sciences(INEST, CAS), was adopted to illustrate the influence of beryllium on an LMR.