Gallbladder cancer(GBC)is a rare and lethal malignancy;however,it represents the most common type of biliary tract cancer.Patients with GBC are often diagnosed at an advanced stage,thus,unfortunately,losing the opport...Gallbladder cancer(GBC)is a rare and lethal malignancy;however,it represents the most common type of biliary tract cancer.Patients with GBC are often diagnosed at an advanced stage,thus,unfortunately,losing the opportunity for curative surgical intervention.This situation leads to lower quality of life and higher mortality rates.In recent years,the rapid development of endoscopic equipment and techniques has provided new avenues and possibilities for the early and minimally invasive diagnosis and treatment of GBC.This editorial comments on the article by Pavlidis et al.Building upon their work,we explore the new needs and corresponding models for managing GBC from the endoscopic diagnosis and treatment perspective.展开更多
The described structural model tries to answer some open questions such as: Why do quarks not exist in the open state? Where are the antiparticles from the Big Bang?
This paper focuses on the problems,opportunities,and challenges faced by software engineering education in the new era.We have studied the core ideas of the new model and reform,the specific measures implemented,and t...This paper focuses on the problems,opportunities,and challenges faced by software engineering education in the new era.We have studied the core ideas of the new model and reform,the specific measures implemented,and the challenges and solutions faced.The new model and reform must focus on cultivating practical abilities,introducing interdisciplinary knowledge,and strengthening innovation awareness and entrepreneurial spirit.The process of reform and innovation is carried out from the aspects of teaching methods,teaching means,and course performance evaluation in the teaching practice of software engineering courses.We adopt a method of“question guiding,simple and easy to understand,flexible and diverse,and emphasizing practical results”,optimizing the curriculum design,providing diverse learning opportunities,and establishing a platform for the industry-university-research cooperation.Our teaching philosophy is to adhere to the viewpoint of innovative teaching ideas,optimizing teaching methods and teaching means,and comprehensively improving the teaching quality and level of software engineering education.展开更多
The present study has obtained the new model of the reservoir filtration problem by taking into account the effect of wellbore storage and skin and by making use of the coupled equations of doubled porous media filtra...The present study has obtained the new model of the reservoir filtration problem by taking into account the effect of wellbore storage and skin and by making use of the coupled equations of doubled porous media filtration and consequently has got, through various forms of limits, the exact analytical solutions of the three common reservoirs (fissure, homogeneous and the two-layered) pressure distribution under the conditions of three boundaries, i.e., infinite boundary, sealed finite boundary and the finite boundary at constant pressures.展开更多
Objective Aeolian sediments on the Chinese Loess Plateau contain some of the best continental archives of palaeoclimate change in the Late Cenozoic. The consensus that alternating MS in loess-paleosols in China was du...Objective Aeolian sediments on the Chinese Loess Plateau contain some of the best continental archives of palaeoclimate change in the Late Cenozoic. The consensus that alternating MS in loess-paleosols in China was due to the strengthening and weakening of the East Asian palaeomonsoon provides an excellent climate record when correlated with global ice volume. Significantly, new basal dates from the red clay underlying the loess-paleosol sequence indicate that wind-blown dust began to accumulate on the Chinese Loess Plateau at least 22 million years ago. There are differences of opinion,展开更多
The principal assumptions about equivalence and energy distribution of the asdorption sites on solidsurfaces used by Langmuir for deriving the equation of monomolecular adsorption are generalized and anew physical ads...The principal assumptions about equivalence and energy distribution of the asdorption sites on solidsurfaces used by Langmuir for deriving the equation of monomolecular adsorption are generalized and anew physical adsorption model is proposed and tested with experimental data published in literature.Themodels of Langmuir,Freundlich,Temkin etc.are only the special cases.Assuming uniform density distributionof adsorption energy,the isotherm equation is given asn=K.1n[1+（bop）1/Mor n=K.1n[1+（boC）1/M]where n is the amount of adsorption per unit weight or area of solid p or C is tbe pressure of gas or the concen-tration of solution respectively.K,bo,M are constants with physical meanings as described in this paper.This equation can be used over wide range to quantitatively represent the five types of physical adsorptionclassified by Brunauer.展开更多
Vulvodynia is a prevalent form of chronic pain, most com- monly affecting the vaginal vestibule （vestibulodynia） （Pukall et al., 2016）. Women with vulvodynia describe intense pain in response to light touch of the...Vulvodynia is a prevalent form of chronic pain, most com- monly affecting the vaginal vestibule （vestibulodynia） （Pukall et al., 2016）. Women with vulvodynia describe intense pain in response to light touch of the affected region, such that sexual function and other activities can be severely limited. Medical costs associated with vulvodynia are high, exceeding $21 billion annually in the United States （Xie et al., 2012）. The high level of direct medical costs has been linked to high treatment failure rates. Many women with the disorder consult multiple practitioners and undergo multiple courses of treatment with limited benefit.展开更多
An analytical model of a ring with six yield hinges and two deformable arc segments is presented for. the prediction of the buckle propagation pressure and initiation pressure in offshore pipelines. The configuration ...An analytical model of a ring with six yield hinges and two deformable arc segments is presented for. the prediction of the buckle propagation pressure and initiation pressure in offshore pipelines. The configuration of a fully collapsed ring is considered as a real dumbbell shape with a line touch between two 'bells', instead of the dumbbell shape with a point touch of two diametrically opposite points. Calculations are performed assuming that the dominant effect on the plastic energy dissipation has the circumferential bending mode. For the linear strain-hardening materials it is found that theoretical predictions based on the above model for both propagation pressure and initiation nressure are in good agreement with experimental results of Kyriakides et al.展开更多
This paper establishes a new model for calculation of the standard entropies of solid binary oxides as follows: S_(29)=27.07×Φ_1+1.120×Φ_2+n_1×k×Φ, -22.19 e.u (R=0.9960) We have invesigated 103 ...This paper establishes a new model for calculation of the standard entropies of solid binary oxides as follows: S_(29)=27.07×Φ_1+1.120×Φ_2+n_1×k×Φ, -22.19 e.u (R=0.9960) We have invesigated 103 binary oxides. and found good agreemenl between estimated and experimental entropies.展开更多
How to extend the flexibility of the budget control to adapt for need of strategy management and management control is a difficult and very important problem. The purpose of this paper is to study tentatively this pro...How to extend the flexibility of the budget control to adapt for need of strategy management and management control is a difficult and very important problem. The purpose of this paper is to study tentatively this problem based on the extant results of controllability principle and budgeting in management control system of organization. In this paper, three main results are as follows： （1） To disclose that the controllability of an organization is one characteristic of the budgeting systems and the controllability is not impartial and not single personal action. （2） To discuss tentatively an improved budgeting system to improve the several weaknesses of traditional budgeting control that Otley （1999） summarized from the academic and practitioner literatures in order to improve the controllability of strategy management with budget flexibility. （3） To build the new model of flexible budget with three new features： it makes strategy objectives easily achievable and controllable; it makes controllers have a more strategic role; it can balance these multiple goals when they cannot be achieved simultaneously and external conditions are more demanding.展开更多
To cope with the current crisis and tensions full-filled China-US relationship, Chinese President Xi Jinping put forward the concept of building a new model of China-US big power relations, which the US agrees. Yet th...To cope with the current crisis and tensions full-filled China-US relationship, Chinese President Xi Jinping put forward the concept of building a new model of China-US big power relations, which the US agrees. Yet the new model won a heated discussion. In China this new model was evaluated positively and optimistically, while in the US it was perceived as a strategic challenge or even a threat. In the present article, the author proposes that this new model of China-US big power relations is more like a symbolic sign in foreign affairs rather than a strategic challenge or a threat or an effective and workable mechanism at this moment, and meanwhile analyses this view from diachronic and semiotic perspectives. The analyses reveal that the new model functions as a symbolic sign, signifying to the world that conceptually the two big powers have a good and harmonious relationship.展开更多
The Tianjin Mini-Automobile Factory is a main engine factory of the Tianjin Aotomoibile Industry (Group) Co. Ltd., and also a manufacturer of the Charade sedan cars of economy model. It is one of China’s four major s...The Tianjin Mini-Automobile Factory is a main engine factory of the Tianjin Aotomoibile Industry (Group) Co. Ltd., and also a manufacturer of the Charade sedan cars of economy model. It is one of China’s four major sedan car production bases. In 1995, it formed a production capacity of 150 thousand sedan cars. The Charade sedan cars still occupy 60 percent market share of the national taxi market. The Tianjin Mini-Automobile Factory now has a total staff of 3,914. It covers an ama of 429,000 square metres,展开更多
At the China International Food Packing Machinery Exhibition, the new model die set for PET plastic jet-mouldingmachine developed by the Zhejiang Province Taizhou Municipality Huangyan Sanyou Plastics Factory attracte...At the China International Food Packing Machinery Exhibition, the new model die set for PET plastic jet-mouldingmachine developed by the Zhejiang Province Taizhou Municipality Huangyan Sanyou Plastics Factory attracted the attention of numerous domestic and foreign clients. They rushed to the stand in great numbers for consultation and talks on ordering. According to the evaluation of the experts concerned, the die set is the most advanced one nationwide for PET plastic jet-moulding machinery.展开更多
This paper has researched on six kinds of the corporate DNA models, which have set up and analyzed its limitations, regarded the corporation as a vital organism, and put forward the judging standard for corporate DNA ...This paper has researched on six kinds of the corporate DNA models, which have set up and analyzed its limitations, regarded the corporation as a vital organism, and put forward the judging standard for corporate DNA by analogism. According to the standard, the components of the corporate DNA are judged and a new model has been established. The corporate DNA is composed of four DNA chains, which overlap and intercross in the model. Based on the new model, the concept of the corporate central dogma is put forward. The element and information transmission way of corporate information are discussed in the corporate central dogma.展开更多
Proposed by the Chinese Government,China and 16 Central and East European(CEE)countries jointly launched the framework of 16+1 cooperation in 2012.China has actively practiced the concept of openness,inclusiveness and...Proposed by the Chinese Government,China and 16 Central and East European(CEE)countries jointly launched the framework of 16+1 cooperation in 2012.China has actively practiced the concept of openness,inclusiveness and win-win cooperation,putting it into the framework of 16+1 cooperation and making new attempts in constructing a new model of international relations.Over the展开更多
As a significant inducement during the development of oil and gas,the role of remaining recoverable reserves is more observable especially in the later phase of development of oilfield.Depended on the production decli...As a significant inducement during the development of oil and gas,the role of remaining recoverable reserves is more observable especially in the later phase of development of oilfield.Depended on the production decline method in petroleum reservoir engineering,a new model of predicting recoverable and remaining recoverable reserves has been展开更多
BACKGROUND Circular RNAs(circRNAs)are involved in the pathogenesis of many diseases through competing endogenous RNA(ceRNA)regulatory mechanisms.AIM To investigate a circRNA-related ceRNA regulatory network and a new ...BACKGROUND Circular RNAs(circRNAs)are involved in the pathogenesis of many diseases through competing endogenous RNA(ceRNA)regulatory mechanisms.AIM To investigate a circRNA-related ceRNA regulatory network and a new predictive model by circRNA to understand the diagnostic mechanism of circRNAs in ulcerative colitis(UC).METHODS We obtained gene expression profiles of circRNAs,miRNAs,and mRNAs in UC from the Gene Expression Omnibus dataset.The circRNA-miRNA-mRNA network was constructed based on circRNA-miRNA and miRNA-mRNA interactions.Functional enrichment analysis was performed to identify the biological mechanisms involved in circRNAs.We identified the most relevant differential circRNAs for diagnosing UC and constructed a new predictive nomogram,whose efficacy was tested with the C-index,receiver operating characteristic curve(ROC),and decision curve analysis(DCA).RESULTS A circRNA-miRNA-mRNA regulatory network was obtained,containing 12 circRNAs,three miRNAs,and 38 mRNAs.Two optimal prognostic-related differentially expressed circRNAs,hsa_circ_0085323 and hsa_circ_0036906,were included to construct a predictive nomogram.The model showed good discrimination,with a C-index of 1(>0.9,high accuracy).ROC and DCA suggested that the nomogram had a beneficial diagnostic ability.CONCLUSION This novel predictive nomogram incorporating hsa_circ_0085323 and hsa_circ_0036906 can be conveniently used to predict the risk of UC.The circRNa-miRNA-mRNA network in UC could be more clinically significant.展开更多
Objective:To explore the impact of the construction of a clinical midwifery teaching faculty and the development of an evaluation system under the new nursing model on the current teaching quality.Methods:From July 20...Objective:To explore the impact of the construction of a clinical midwifery teaching faculty and the development of an evaluation system under the new nursing model on the current teaching quality.Methods:From July 2022 to March 2023,10 clinical teaching teachers and 20 midwifery interns from Beijing Anzhen Hospital affiliated with Capital Medical University were selected as the subjects of this study.The clinical teaching teachers and midwifery interns were divided into an observation group and a control group,with each group including 5 clinical teaching teachers and 10 midwifery interns.The observation group received daily management and evaluation under the new nursing model,while the control group received management and evaluation under the traditional nursing model.The teaching quality evaluation of clinical midwifery teaching teachers by midwifery interns,the exit exam scores of midwifery interns,and the scores of clinical teaching teachers’internship lectures and teaching rounds were compared between the two groups.Results:In the observation group,the scores for teaching attitude,teaching skills,and teaching management in the teaching quality evaluation of clinical midwifery teaching teachers were higher than those in the control group.The professional theory scores(91.28±3.64)and overall nursing comprehensive scores(92.56±4.38)of midwifery interns in the observation group were higher than those of midwifery interns in the control group(81.58±2.27 and 80.29±3.33,respectively).The scores for internship lectures(89.32±4.15)and teaching rounds(90.64±5.52)in the observation group were also significantly higher than those in the control group(80.46±3.28 and 81.24±4.38,respectively),and the differences were statistically significant(P<0.05).Conclusion:The management of the clinical midwifery teaching faculty under the new nursing model effectively improved the quality of clinical teaching.It significantly enhanced the teaching effectiveness of clinical teaching teachers and the proficiency of midwifery interns in clinical operations,making it worthy of promotion and use.展开更多
Clastic rock reservoir is the main reservoir type in the oil and gas field.Archie formula or various conductive models developed on the basis of Archie’s formula are usually used to interpret this kind of reservoir,a...Clastic rock reservoir is the main reservoir type in the oil and gas field.Archie formula or various conductive models developed on the basis of Archie’s formula are usually used to interpret this kind of reservoir,and the three-water model is widely used as well.However,there are many parameters in the threewater model,and some of them are difficult to determine.Most of the determination methods are based on the statistics of large amount of experimental data.In this study,the authors determine the value of the parameters of the new three-water model based on the nuclear magnetic data and the genetic optimization algorithm.The relative error between the resistivity calculated based on these parameters and the resistivity measured experimentally at 100%water content is 0.9024.The method studied in this paper can be easily applied without much experimental data.It can provide reference for other regions to determine the parameters of the new three-water model.展开更多
Study on crack propagation process of brittle rock is of most significance for cracking-arrest design and cracking-network optimization in rock engineering.Phase-field model(PFM)has advantages of simplicity and high c...Study on crack propagation process of brittle rock is of most significance for cracking-arrest design and cracking-network optimization in rock engineering.Phase-field model(PFM)has advantages of simplicity and high convergence over the common numerical methods(e.g.finite element method,discrete element method,and particle manifold method)in dealing with three-dimensional and multicrack problems.However,current PFMs are mainly used to simulate mode-I(tensile)crack propagation but difficult to effectively simulate mode-II(shear)crack propagation.In this paper,a new mixed-mode PFM is established to simulate both mode-I and mode-II crack propagation of brittle rock by distinguishing the volumetric elastic strain energy and deviatoric elastic strain energy in the total elastic strain energy and considering the effect of compressive stress on mode-II crack propagation.Numerical solution method of the new mixed-mode PFM is proposed based on the staggered solution method with self-programmed subroutines UMAT and HETVAL of ABAQUS software.Three examples calculated using different PFMs as well as test results are presented for comparison.The results show that compared with the conventional PFM(which only simulates the tensile wing crack but not mode-II crack propagation)and the modified mixed-mode PFM(which has difficulty in simulating the shear anti-wing crack),the new mixed-mode PFM can successfully simulate the whole trajectories of mixed-mode crack propagation(including the tensile wing crack,shear secondary crack,and shear anti-wing crack)and mode-II crack propagation,which are close to the test results.It can be further extended to simulate multicrack propagation of anisotropic rock under multi-field coupling loads.展开更多
基金the Education and Teaching Reform Project of the First Clinical College of Chongqing Medical University,No.CMER202305the Program for Youth Innovation in Future Medicine,Chongqing Medical University,No.W0138.
文摘Gallbladder cancer(GBC)is a rare and lethal malignancy;however,it represents the most common type of biliary tract cancer.Patients with GBC are often diagnosed at an advanced stage,thus,unfortunately,losing the opportunity for curative surgical intervention.This situation leads to lower quality of life and higher mortality rates.In recent years,the rapid development of endoscopic equipment and techniques has provided new avenues and possibilities for the early and minimally invasive diagnosis and treatment of GBC.This editorial comments on the article by Pavlidis et al.Building upon their work,we explore the new needs and corresponding models for managing GBC from the endoscopic diagnosis and treatment perspective.
文摘The described structural model tries to answer some open questions such as: Why do quarks not exist in the open state? Where are the antiparticles from the Big Bang?
基金supported in part by the postgraduate demonstration course of Guangdong Province Department of Education Programmed Trading(No.2023SFKC_022)the Computer Architecture First Class Course Project,South China Normal University-Baidu Pineapple Talent Training Practice Basethe 2023 Project of Computer Education Research Association of Chinese Universities(No.CERACU2023R02)。
文摘This paper focuses on the problems,opportunities,and challenges faced by software engineering education in the new era.We have studied the core ideas of the new model and reform,the specific measures implemented,and the challenges and solutions faced.The new model and reform must focus on cultivating practical abilities,introducing interdisciplinary knowledge,and strengthening innovation awareness and entrepreneurial spirit.The process of reform and innovation is carried out from the aspects of teaching methods,teaching means,and course performance evaluation in the teaching practice of software engineering courses.We adopt a method of“question guiding,simple and easy to understand,flexible and diverse,and emphasizing practical results”,optimizing the curriculum design,providing diverse learning opportunities,and establishing a platform for the industry-university-research cooperation.Our teaching philosophy is to adhere to the viewpoint of innovative teaching ideas,optimizing teaching methods and teaching means,and comprehensively improving the teaching quality and level of software engineering education.
文摘The present study has obtained the new model of the reservoir filtration problem by taking into account the effect of wellbore storage and skin and by making use of the coupled equations of doubled porous media filtration and consequently has got, through various forms of limits, the exact analytical solutions of the three common reservoirs (fissure, homogeneous and the two-layered) pressure distribution under the conditions of three boundaries, i.e., infinite boundary, sealed finite boundary and the finite boundary at constant pressures.
基金co-supported by the National Natural Science Foundation of China(grants No.41421002, 41372037,41372036,41372020 and 41002052)
文摘Objective Aeolian sediments on the Chinese Loess Plateau contain some of the best continental archives of palaeoclimate change in the Late Cenozoic. The consensus that alternating MS in loess-paleosols in China was due to the strengthening and weakening of the East Asian palaeomonsoon provides an excellent climate record when correlated with global ice volume. Significantly, new basal dates from the red clay underlying the loess-paleosol sequence indicate that wind-blown dust began to accumulate on the Chinese Loess Plateau at least 22 million years ago. There are differences of opinion,
文摘The principal assumptions about equivalence and energy distribution of the asdorption sites on solidsurfaces used by Langmuir for deriving the equation of monomolecular adsorption are generalized and anew physical adsorption model is proposed and tested with experimental data published in literature.Themodels of Langmuir,Freundlich,Temkin etc.are only the special cases.Assuming uniform density distributionof adsorption energy,the isotherm equation is given asn=K.1n[1+（bop）1/Mor n=K.1n[1+（boC）1/M]where n is the amount of adsorption per unit weight or area of solid p or C is tbe pressure of gas or the concen-tration of solution respectively.K,bo,M are constants with physical meanings as described in this paper.This equation can be used over wide range to quantitatively represent the five types of physical adsorptionclassified by Brunauer.
基金A project described in this work regarding innervation changes in the murine vagina in response to inflammation was supported by a grant from the Centre for Neuroscience,Flinders University,Australia
文摘Vulvodynia is a prevalent form of chronic pain, most com- monly affecting the vaginal vestibule （vestibulodynia） （Pukall et al., 2016）. Women with vulvodynia describe intense pain in response to light touch of the affected region, such that sexual function and other activities can be severely limited. Medical costs associated with vulvodynia are high, exceeding $21 billion annually in the United States （Xie et al., 2012）. The high level of direct medical costs has been linked to high treatment failure rates. Many women with the disorder consult multiple practitioners and undergo multiple courses of treatment with limited benefit.
基金Project supported by National Natural Science Foundation
文摘An analytical model of a ring with six yield hinges and two deformable arc segments is presented for. the prediction of the buckle propagation pressure and initiation pressure in offshore pipelines. The configuration of a fully collapsed ring is considered as a real dumbbell shape with a line touch between two 'bells', instead of the dumbbell shape with a point touch of two diametrically opposite points. Calculations are performed assuming that the dominant effect on the plastic energy dissipation has the circumferential bending mode. For the linear strain-hardening materials it is found that theoretical predictions based on the above model for both propagation pressure and initiation nressure are in good agreement with experimental results of Kyriakides et al.
文摘This paper establishes a new model for calculation of the standard entropies of solid binary oxides as follows: S_(29)=27.07×Φ_1+1.120×Φ_2+n_1×k×Φ, -22.19 e.u (R=0.9960) We have invesigated 103 binary oxides. and found good agreemenl between estimated and experimental entropies.
文摘How to extend the flexibility of the budget control to adapt for need of strategy management and management control is a difficult and very important problem. The purpose of this paper is to study tentatively this problem based on the extant results of controllability principle and budgeting in management control system of organization. In this paper, three main results are as follows： （1） To disclose that the controllability of an organization is one characteristic of the budgeting systems and the controllability is not impartial and not single personal action. （2） To discuss tentatively an improved budgeting system to improve the several weaknesses of traditional budgeting control that Otley （1999） summarized from the academic and practitioner literatures in order to improve the controllability of strategy management with budget flexibility. （3） To build the new model of flexible budget with three new features： it makes strategy objectives easily achievable and controllable; it makes controllers have a more strategic role; it can balance these multiple goals when they cannot be achieved simultaneously and external conditions are more demanding.
文摘To cope with the current crisis and tensions full-filled China-US relationship, Chinese President Xi Jinping put forward the concept of building a new model of China-US big power relations, which the US agrees. Yet the new model won a heated discussion. In China this new model was evaluated positively and optimistically, while in the US it was perceived as a strategic challenge or even a threat. In the present article, the author proposes that this new model of China-US big power relations is more like a symbolic sign in foreign affairs rather than a strategic challenge or a threat or an effective and workable mechanism at this moment, and meanwhile analyses this view from diachronic and semiotic perspectives. The analyses reveal that the new model functions as a symbolic sign, signifying to the world that conceptually the two big powers have a good and harmonious relationship.
文摘The Tianjin Mini-Automobile Factory is a main engine factory of the Tianjin Aotomoibile Industry (Group) Co. Ltd., and also a manufacturer of the Charade sedan cars of economy model. It is one of China’s four major sedan car production bases. In 1995, it formed a production capacity of 150 thousand sedan cars. The Charade sedan cars still occupy 60 percent market share of the national taxi market. The Tianjin Mini-Automobile Factory now has a total staff of 3,914. It covers an ama of 429,000 square metres,
文摘At the China International Food Packing Machinery Exhibition, the new model die set for PET plastic jet-mouldingmachine developed by the Zhejiang Province Taizhou Municipality Huangyan Sanyou Plastics Factory attracted the attention of numerous domestic and foreign clients. They rushed to the stand in great numbers for consultation and talks on ordering. According to the evaluation of the experts concerned, the die set is the most advanced one nationwide for PET plastic jet-moulding machinery.
文摘This paper has researched on six kinds of the corporate DNA models, which have set up and analyzed its limitations, regarded the corporation as a vital organism, and put forward the judging standard for corporate DNA by analogism. According to the standard, the components of the corporate DNA are judged and a new model has been established. The corporate DNA is composed of four DNA chains, which overlap and intercross in the model. Based on the new model, the concept of the corporate central dogma is put forward. The element and information transmission way of corporate information are discussed in the corporate central dogma.
文摘Proposed by the Chinese Government,China and 16 Central and East European(CEE)countries jointly launched the framework of 16+1 cooperation in 2012.China has actively practiced the concept of openness,inclusiveness and win-win cooperation,putting it into the framework of 16+1 cooperation and making new attempts in constructing a new model of international relations.Over the
文摘As a significant inducement during the development of oil and gas,the role of remaining recoverable reserves is more observable especially in the later phase of development of oilfield.Depended on the production decline method in petroleum reservoir engineering,a new model of predicting recoverable and remaining recoverable reserves has been
基金Supported by the National Natural Science Foundation of China,No.81774093,No.81904009,No.81974546 and No.82174182Key R&D Project of Hubei Province,No.2020BCB001.
文摘BACKGROUND Circular RNAs(circRNAs)are involved in the pathogenesis of many diseases through competing endogenous RNA(ceRNA)regulatory mechanisms.AIM To investigate a circRNA-related ceRNA regulatory network and a new predictive model by circRNA to understand the diagnostic mechanism of circRNAs in ulcerative colitis(UC).METHODS We obtained gene expression profiles of circRNAs,miRNAs,and mRNAs in UC from the Gene Expression Omnibus dataset.The circRNA-miRNA-mRNA network was constructed based on circRNA-miRNA and miRNA-mRNA interactions.Functional enrichment analysis was performed to identify the biological mechanisms involved in circRNAs.We identified the most relevant differential circRNAs for diagnosing UC and constructed a new predictive nomogram,whose efficacy was tested with the C-index,receiver operating characteristic curve(ROC),and decision curve analysis(DCA).RESULTS A circRNA-miRNA-mRNA regulatory network was obtained,containing 12 circRNAs,three miRNAs,and 38 mRNAs.Two optimal prognostic-related differentially expressed circRNAs,hsa_circ_0085323 and hsa_circ_0036906,were included to construct a predictive nomogram.The model showed good discrimination,with a C-index of 1(>0.9,high accuracy).ROC and DCA suggested that the nomogram had a beneficial diagnostic ability.CONCLUSION This novel predictive nomogram incorporating hsa_circ_0085323 and hsa_circ_0036906 can be conveniently used to predict the risk of UC.The circRNa-miRNA-mRNA network in UC could be more clinically significant.
基金Capital Medical University 2023 Education and Teaching Reform Research Project“Study on the Construction and Evaluation System of Clinical Midwifery Teaching Faculty under the New Nursing Model”(Project No.2023JYZ028)。
文摘Objective:To explore the impact of the construction of a clinical midwifery teaching faculty and the development of an evaluation system under the new nursing model on the current teaching quality.Methods:From July 2022 to March 2023,10 clinical teaching teachers and 20 midwifery interns from Beijing Anzhen Hospital affiliated with Capital Medical University were selected as the subjects of this study.The clinical teaching teachers and midwifery interns were divided into an observation group and a control group,with each group including 5 clinical teaching teachers and 10 midwifery interns.The observation group received daily management and evaluation under the new nursing model,while the control group received management and evaluation under the traditional nursing model.The teaching quality evaluation of clinical midwifery teaching teachers by midwifery interns,the exit exam scores of midwifery interns,and the scores of clinical teaching teachers’internship lectures and teaching rounds were compared between the two groups.Results:In the observation group,the scores for teaching attitude,teaching skills,and teaching management in the teaching quality evaluation of clinical midwifery teaching teachers were higher than those in the control group.The professional theory scores(91.28±3.64)and overall nursing comprehensive scores(92.56±4.38)of midwifery interns in the observation group were higher than those of midwifery interns in the control group(81.58±2.27 and 80.29±3.33,respectively).The scores for internship lectures(89.32±4.15)and teaching rounds(90.64±5.52)in the observation group were also significantly higher than those in the control group(80.46±3.28 and 81.24±4.38,respectively),and the differences were statistically significant(P<0.05).Conclusion:The management of the clinical midwifery teaching faculty under the new nursing model effectively improved the quality of clinical teaching.It significantly enhanced the teaching effectiveness of clinical teaching teachers and the proficiency of midwifery interns in clinical operations,making it worthy of promotion and use.
文摘Clastic rock reservoir is the main reservoir type in the oil and gas field.Archie formula or various conductive models developed on the basis of Archie’s formula are usually used to interpret this kind of reservoir,and the three-water model is widely used as well.However,there are many parameters in the threewater model,and some of them are difficult to determine.Most of the determination methods are based on the statistics of large amount of experimental data.In this study,the authors determine the value of the parameters of the new three-water model based on the nuclear magnetic data and the genetic optimization algorithm.The relative error between the resistivity calculated based on these parameters and the resistivity measured experimentally at 100%water content is 0.9024.The method studied in this paper can be easily applied without much experimental data.It can provide reference for other regions to determine the parameters of the new three-water model.
基金supports by National Natural Science Foundation of China(Grant Nos.51874351 and 52078495)Excellent Postdoctoral Innovative Talents Project of Hunan Province,China(Grant No.2020RC2001).
文摘Study on crack propagation process of brittle rock is of most significance for cracking-arrest design and cracking-network optimization in rock engineering.Phase-field model(PFM)has advantages of simplicity and high convergence over the common numerical methods(e.g.finite element method,discrete element method,and particle manifold method)in dealing with three-dimensional and multicrack problems.However,current PFMs are mainly used to simulate mode-I(tensile)crack propagation but difficult to effectively simulate mode-II(shear)crack propagation.In this paper,a new mixed-mode PFM is established to simulate both mode-I and mode-II crack propagation of brittle rock by distinguishing the volumetric elastic strain energy and deviatoric elastic strain energy in the total elastic strain energy and considering the effect of compressive stress on mode-II crack propagation.Numerical solution method of the new mixed-mode PFM is proposed based on the staggered solution method with self-programmed subroutines UMAT and HETVAL of ABAQUS software.Three examples calculated using different PFMs as well as test results are presented for comparison.The results show that compared with the conventional PFM(which only simulates the tensile wing crack but not mode-II crack propagation)and the modified mixed-mode PFM(which has difficulty in simulating the shear anti-wing crack),the new mixed-mode PFM can successfully simulate the whole trajectories of mixed-mode crack propagation(including the tensile wing crack,shear secondary crack,and shear anti-wing crack)and mode-II crack propagation,which are close to the test results.It can be further extended to simulate multicrack propagation of anisotropic rock under multi-field coupling loads.
