<strong>Background:</strong><span style="font-family:""><span style="font-family:Verdana;"> Recently, among child disability disorders nervous system diseases are preva...<strong>Background:</strong><span style="font-family:""><span style="font-family:Verdana;"> Recently, among child disability disorders nervous system diseases are prevailing 19.5%, while mental disorders are 14.3% and congenital malformations 21%. In most cases, children’s neurological disability is associated with pathology during the perinatal period, while 24% of patients have a cerebral impairment. Premature newborns perished 30 to 35 times more often than in-time newborns, and perinatal mortality in case of premature pregnancies is 30 to 40 times higher than in term delivery. </span><b><span style="font-family:Verdana;">Aim:</span></b><span style="font-family:Verdana;"> This article is studying catamnestic observation of premature newborns with nervous sys</span><span style="font-family:Verdana;">tem injury and with perinatal pathology in Kyrgyzstan for the period</span><span style="font-family:Verdana;"> 2020-2021. Preterm newborns’ anthropometric characteristics and main diagnoses associated with diseases in the gestational period were shown. </span><b><span style="font-family:Verdana;">Methods: </span></b><span style="font-family:Verdana;">A comprehensive clinical and laboratory examination including premature newborns health dynamic monitoring with gestational age from 28 to 36 weeks, who were treated in the neonatal pathology department of the Regional Maternity Hospital in Osh for the period from 2020-2021 were carried out. Literature review analysis from PubMed database, MEDLINE, EMBASE, Science Direct, Google Scholar, and clinical trials performed. </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">after clinical examination, it was revealed that pregnancy and childbirth in all mothers of the studied group passed with complications.</span><b> </b><span style="font-family:Verdana;">In mothers of the studying group, the most common pathologies during pregnancy were chronic fetal hypoxia 49 (58.4%), acute respiratory infections 28 (33.4%), the threat of termination of pregnancy 20 (23.9%), preeclampsia 16 (19.11%), sexually transmitted infections 9 (10.8%), pyelonephritis 14 (16.7%), polyhydramnios 9 (10.8%), 71 children (84.6%) were born with asphyxiation and 25 children extracted by cesarean section with varying degrees of severity.</span><b><span style="font-family:Verdana;"> Conclusions: </span></b><span style="font-family:Verdana;">Depending on the severity of the perinatal lesion of the nervous system and pathological factor effects, it is very important to start early habilitation measures with preterm newborns who are at risk of developmental delay deviations, and to exit disabling disorders.</span></span>展开更多
Parkinson’s disease (PD) is a debilitating neurological disorder that affects <span>the aged population globally. This study aimed to explore how oral- and in</span>traperitoneal-rotenone-induced PD alter...Parkinson’s disease (PD) is a debilitating neurological disorder that affects <span>the aged population globally. This study aimed to explore how oral- and in</span>traperitoneal-rotenone-induced PD alters brain urea levels, histopathology, and key Parkinsonism<span>-related genes in the striatum. Hematoxylin and eosin staining was performed for histopathology assessment and real-time polymerase chain reaction was performed for gene expression. Rotenone 3 mg/kg body weight (Rot-3-ip) for 21 days and rotenone 50 mg/kg body weight (Rot-50-po) for 28 days significantly (p < 0.05) altered alpha-synuclein and tyrosine hydroxylase protein expression and <i>Snca</i>, <i>Becn</i>1 and <i>Prkaa</i>1 gene expression in the striatum. Lewy bodies were visible in both Rot-3-ip and Rot-50-po rat brains. There were </span><span>contrasting features in brain and liver histopathology between the oral and</span><span> intraperitoneal rotenone treatment groups. However, there was no significant (p < 0.05) difference in the brain urea levels between intraperitoneal and oral rotenone treatment groups. The propagation of PD through oral and intraperitoneal rotenone</span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:"">can have different impacts on the pathological sequence of events based on the molecular approach.展开更多
文摘<strong>Background:</strong><span style="font-family:""><span style="font-family:Verdana;"> Recently, among child disability disorders nervous system diseases are prevailing 19.5%, while mental disorders are 14.3% and congenital malformations 21%. In most cases, children’s neurological disability is associated with pathology during the perinatal period, while 24% of patients have a cerebral impairment. Premature newborns perished 30 to 35 times more often than in-time newborns, and perinatal mortality in case of premature pregnancies is 30 to 40 times higher than in term delivery. </span><b><span style="font-family:Verdana;">Aim:</span></b><span style="font-family:Verdana;"> This article is studying catamnestic observation of premature newborns with nervous sys</span><span style="font-family:Verdana;">tem injury and with perinatal pathology in Kyrgyzstan for the period</span><span style="font-family:Verdana;"> 2020-2021. Preterm newborns’ anthropometric characteristics and main diagnoses associated with diseases in the gestational period were shown. </span><b><span style="font-family:Verdana;">Methods: </span></b><span style="font-family:Verdana;">A comprehensive clinical and laboratory examination including premature newborns health dynamic monitoring with gestational age from 28 to 36 weeks, who were treated in the neonatal pathology department of the Regional Maternity Hospital in Osh for the period from 2020-2021 were carried out. Literature review analysis from PubMed database, MEDLINE, EMBASE, Science Direct, Google Scholar, and clinical trials performed. </span><b><span style="font-family:Verdana;">Results: </span></b><span style="font-family:Verdana;">after clinical examination, it was revealed that pregnancy and childbirth in all mothers of the studied group passed with complications.</span><b> </b><span style="font-family:Verdana;">In mothers of the studying group, the most common pathologies during pregnancy were chronic fetal hypoxia 49 (58.4%), acute respiratory infections 28 (33.4%), the threat of termination of pregnancy 20 (23.9%), preeclampsia 16 (19.11%), sexually transmitted infections 9 (10.8%), pyelonephritis 14 (16.7%), polyhydramnios 9 (10.8%), 71 children (84.6%) were born with asphyxiation and 25 children extracted by cesarean section with varying degrees of severity.</span><b><span style="font-family:Verdana;"> Conclusions: </span></b><span style="font-family:Verdana;">Depending on the severity of the perinatal lesion of the nervous system and pathological factor effects, it is very important to start early habilitation measures with preterm newborns who are at risk of developmental delay deviations, and to exit disabling disorders.</span></span>
文摘Parkinson’s disease (PD) is a debilitating neurological disorder that affects <span>the aged population globally. This study aimed to explore how oral- and in</span>traperitoneal-rotenone-induced PD alters brain urea levels, histopathology, and key Parkinsonism<span>-related genes in the striatum. Hematoxylin and eosin staining was performed for histopathology assessment and real-time polymerase chain reaction was performed for gene expression. Rotenone 3 mg/kg body weight (Rot-3-ip) for 21 days and rotenone 50 mg/kg body weight (Rot-50-po) for 28 days significantly (p < 0.05) altered alpha-synuclein and tyrosine hydroxylase protein expression and <i>Snca</i>, <i>Becn</i>1 and <i>Prkaa</i>1 gene expression in the striatum. Lewy bodies were visible in both Rot-3-ip and Rot-50-po rat brains. There were </span><span>contrasting features in brain and liver histopathology between the oral and</span><span> intraperitoneal rotenone treatment groups. However, there was no significant (p < 0.05) difference in the brain urea levels between intraperitoneal and oral rotenone treatment groups. The propagation of PD through oral and intraperitoneal rotenone</span></span></span><span><span><span style="font-family:""> </span></span></span><span><span><span style="font-family:"">can have different impacts on the pathological sequence of events based on the molecular approach.
