The purpose of this review is to discuss the advantages and limitations of taste sensors in the evaluation of the taste of palatability of different oral dosage forms. First, we consider some ways in which the palatab...The purpose of this review is to discuss the advantages and limitations of taste sensors in the evaluation of the taste of palatability of different oral dosage forms. First, we consider some ways in which the palatability of various pharmaceutical formulations including orally disintegrating tablets(ODTs) are tested using two different taste sensors. Second, we focus on the evaluation of palatability of ODTs. We compare the usefulness of three pieces of apparatus for estimating the disintegration time of ODTs. Finally, we compare the characteristics of the two taste sensors in the evaluation of palatability of various kinds of drug formulations.展开更多
To clarify the optimal water management in large-scale fields under high temperatures at the ripening period,effective water managements during this period for improvement of yield,appearance quality and palatability ...To clarify the optimal water management in large-scale fields under high temperatures at the ripening period,effective water managements during this period for improvement of yield,appearance quality and palatability were investigated.Compared with intermittent irrigation and flooded irrigation,the soil temperature with saturated irrigation remained low throughout the day,and the decrease rate of the bleeding rate of hills was the lowest.These results suggested that the saturated irrigation maintained root activity.For the three irrigation types,the number of spikelets per m2 and 1000-grain weight were similar,however,saturated irrigation resulted in significantly higher rice yield due to improvement in the percentage of ripened grains.The saturated irrigation produced a high percentage of perfect rice grains and thicker brown rice grain,furthermore,the palatability of cooked rice was excellent because protein content and hardness/adhesion ratio were both low.Thus,under high-temperature ripening conditions,soil temperature was lowered and root activity was maintained when applying saturated irrigation after heading time.The results indicated that saturated irrigation is an effective countermeasure against high-temperature ripening damage.展开更多
For veterinary medications administered per os, animal health companies strive to develop highly palatable dosage forms that are voluntarily accepted by animals to improve compliance and convenience. Achieving high pa...For veterinary medications administered per os, animal health companies strive to develop highly palatable dosage forms that are voluntarily accepted by animals to improve compliance and convenience. Achieving high palatability is often complex and difficult even without the presence of an active ingredient. This work compared acceptance and preference studies, as standardized methods are not established for informing formulation development or for more routine testing. Formulation development was followed by an acceptance study completed with laboratory Beagle dogs. One acceptance study and one preference study were completed in mixed breed dogs, also laboratory-housed, to gain wider representation of dog breed and age. Through these studies, we have evaluated both formulation parameters and palatability study conduct. In general, more complex palatants that have appealing taste, smell, and mouth feel enhance voluntary uptake. However, dosage forms that are too chewy may not be freely consumed even with complex palatants. The addition of aroma can entice dogs to prehend the tablet, as observed in one preference study. Preference studies in the veterinary pharmaceutical field identify the preferred first choice or first prehend, but not which product will be routinely voluntarily and fully consumed. Acceptance studies with cross-over treatment groups are used to quantify the full consumption of a dosage form when a dog is not given two choices at once. Since all dogs in acceptance studies are offered all treatment groups throughout the study, a comparison between degrees of consumption could suggest that one formulation might be preferred over another.展开更多
<span style="font-family:Verdana;">The purpose of this study was to evaluate the palatability of dry syrups for pediatric use by human gustatory sensation testing and the artificial taste sensor. The b...<span style="font-family:Verdana;">The purpose of this study was to evaluate the palatability of dry syrups for pediatric use by human gustatory sensation testing and the artificial taste sensor. The bitterness intensities of dry syrups mixed with various beverages were also evaluated using the taste sensor. Twenty dry-syrup formulations of antibacterial and anti-allergic drugs containing bitter active ingredients, frequently used in pediatric medicine in Japan, were selected for testing. The main factors influencing palatability were determined by factor analysis of data from human gustatory sensation testing using the semantic differential method. It was shown that the bitterness intensity of dry syrups in water could be predicted by the artificial taste sensor. The influence of different beverages (orange juice, milk </span><span style="font-family:Verdana;">or</span><span style="font-family:Verdana;"> cocoa) mixed with the dry syrups was evaluated using the artificial taste sensor.</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">Taste and texture were found to be the principal factors influencing the palatability of dry syrups. While the bitterness intensities of some dry syrups were increased by mixing with orange juice, the bitterness intensities of most dry syrups were decreased by mixing with milk or cocoa. This suggests that one or more constituents of milk or cocoa may reduce the bitterness intensities of dry syrups.</span>展开更多
The nutritive value of rangelands in Southern Darfur, Sudan could be improved by introduction and multiplication of nutritious forbs with the objective of increasing livestock production in the area. The present study...The nutritive value of rangelands in Southern Darfur, Sudan could be improved by introduction and multiplication of nutritious forbs with the objective of increasing livestock production in the area. The present study was conducted to evaluate the nutritive value and palatability of eleven range forbs collected at flowering stage from Gahzal Gawazat, Southern Darfur, Sudan using chemical analysis. The crude protein (CP) ranged from 6.8% in Oxygonum atriplicifolium with lowest digestible crude protein (DCP) 2.8% to 16.4% in Zornia diphylla with highest DCP 11.73%. The highest and the lowest crude fiber (CF) values were obtained in Commelina spp (56.4%) and Sesamum alatum (25.9%), respectively. NDF and DMI values were maximum and minimum for Zornia diphylla (44.9 and 2.67%) and Alysicarpus glumaceus (35.3 and 3.4%), respectively. The total digestible nutrients (TDN) ranged from 57.1% in Blepharis linariifolia to 69.3% in Tribulus terrestris with highest digestible energy (DE) in later while the lowest DE was obtained in Commelina spp (2.4%). The calculated in vitro organic matter digestibility (IVOMD) was highest for the Canavalia ensiformis (50.27%) and lowest value (43.17%) for Commelina spp. Zornia diphylla, Tribulus terrestris and Sesamum alatum showed highest nutritive value, while Alysicarpus glumaceus, Oldenlandia senegalensis and Chrozophora brocchiana showed highest palatability. It is concluded that these rangeland forbs are palatable and their CP and energy contents are sufficient to support different classes of livestock in South Darfur, Sudan.展开更多
There is an increased need for highly palatable oral dosage forms for dogs and cats, especially in the case of regular or chronic medications. To meet this need of easy application, the original Drontal®Plus t...There is an increased need for highly palatable oral dosage forms for dogs and cats, especially in the case of regular or chronic medications. To meet this need of easy application, the original Drontal®Plus tablet, a broad-spectrum anthelminthic, was optimized using a novel formula. A field study was conducted to evaluate the palatability of this new Drontal®Plus formula in comparison to a positive control product (Milbemax®Chewable Tablets) with a well-known high palatability. The study also aimed to get a palatability claim which necessitates the conduct of appropriate studies. 150 privately owned dogs of 38 pure or mixed breeds, six months to twelve years old, and with a weight range of 5 to 50 kg were included. The study was based on a cross-over design, and a standardized acceptance test was used to evaluate and compare the palatability of the two medications. In this study 88% of dogs voluntarily consumed Drontal®Plus Treat 10 kg, and 86.7% accepted Milbemax®Chewable Tablets. In the majority of cases (IVP: 98%, CP: 95%) the tablets were taken directly from the owner’s hand. The new Drontal®Plus tablet showed a high palatability compared to the Milbemax®Chewable Tablets when used in a household study design with privately owned dogs.展开更多
The intensity of the bitterness of catechins increases with increased concentration, but the taste palatability decreased in green tea extract. The aim of this study was to investigate whether a blend of tea leaf part...The intensity of the bitterness of catechins increases with increased concentration, but the taste palatability decreased in green tea extract. The aim of this study was to investigate whether a blend of tea leaf particles of various sizes would result in a good balance between catechin content and appreciable taste. The control is common tea (CT) with 6 - 10 mm long leaves. Blend tea (BT) was prepared by mixing 5 mm and 120 - 130 mm long tea leaves in a ratio of 3:2. The catechin content of hot water extracts was analyzed by HPLC, and the sensory test was conducted with 99 volunteers. In BT, the total catechin content was significantly higher than that in CT. The sensory test results revealed that BT was less bitter and had more preferable color than CT. More catechins were extracted from BT, but it tasted less bitter. Thus, the recalibration of the tea leaf particle size can result in good balance between catechin content and palatability.展开更多
Incidents of soft palate injury or laceration caused by unintended movement when holding a sharp object in the mouth in the pediatric population are usually rarely reported.Here we report a case of soft palate lacerat...Incidents of soft palate injury or laceration caused by unintended movement when holding a sharp object in the mouth in the pediatric population are usually rarely reported.Here we report a case of soft palate laceration in a child due to a lollypop stick tip.展开更多
Introduction: Cleft lip, palate and alveolar (CLPA) are congenital malformations of the face due to a defect in the fusion of embryonic buds during the first weeks of embryogenesis. These malformations affect the uppe...Introduction: Cleft lip, palate and alveolar (CLPA) are congenital malformations of the face due to a defect in the fusion of embryonic buds during the first weeks of embryogenesis. These malformations affect the upper lip, the alveolar bone and the palate. The incidence in Africa ranges from 1/2000 to 1/500 births. Their multidisciplinary management is long and costly. Thus, the help provided by humanitarian organisations during free care campaigns is welcome. Materials and Methods: This is a retrospective descriptive study conducted from August 2014 to July 2016 in the Maxillofacial Surgery and Stomatology Department of the Treichville University Hospital in Abidjan, Côte d’Ivoire. The objective was to describe the epidemiological, clinical and therapeutic aspects of CLPA during a humanitarian campaign for free care. Results: 51 cases of CLPA were operated on. Males were involved in 54.9% of the cases, i.e. a sex ratio of 1.2. The average age of the patients at the time of the operation was 3.44 years with extremes of 3 months and 52 years. Patients with low socioeconomic status represented 84.3% of the cases. Cleft lips (31.4%) and cleft palates (33.33%) predominated. For cleft lips, unilateral forms were the most frequent (73.5%) and the left side was most often affected (59.2%). The most common surgical techniques used were MILLARD cheiloplasty for cleft lips (79.36%) and Dorrance pushback for cleft palates (78.05%). The postoperative course was simple in the majority of cases (80.47%). Patients and/or parents were satisfied with the postoperative results in over 90% of cases. Discussion: Cleft lip and palate are common. Their management by humanitarian missions through mass campaigns allows us to receive a large number of patients affected by this pathology who are treated with a high satisfaction rate. Conclusion: The characteristics of cleft lip and palate in this study are in many respects identical to those described in the literature, but with some differences specific to Africa, notably the absence of antenatal diagnosis and the advanced age at the time of treatment.展开更多
Various surgical techniques and approaches have been described to repair cleft nose deformities. It is necessary to consider that since it is a congenital deformity, surgical management must consider the patient’s gr...Various surgical techniques and approaches have been described to repair cleft nose deformities. It is necessary to consider that since it is a congenital deformity, surgical management must consider the patient’s growth process, as well as the healing itself from the surgery. The present study aims to evaluate an alternative solution to secondary rhinology, aesthetic, and functional alterations to unilateral or bilateral cleft lift palate to minimize deformities and ensure good results. 11 patients were studied between 1995 to 2002, ten male and one female. In 8 cases, the patients had a history of cleft lip and palate on the left side, 2 patients with cleft lift palate on the right, and 1 patient with bilateral cleft lip and palate. 100% of the patients increased their naso-labial angle. This improved their appearance and structure, starting from a preoperative arithmetic mean of 39 degrees to a postoperative arithmetic mean of 96 degrees. Such intervention increased the naso-labial angle by 57 degrees. At the base of the nose, it was possible to improve the inclination of the alar line (line B) in 10 of the cases with a variation of 2 to 3 mm in relation to the perpendicular line A and only one case remained with the same inclination.展开更多
Hainan eldi’s deer is a precious species of deer in the tropic zone,it is regardedas the first—class animal under protection in China.Based on all-year-round observation on thedeer’s feeding habit in the reserve fr...Hainan eldi’s deer is a precious species of deer in the tropic zone,it is regardedas the first—class animal under protection in China.Based on all-year-round observation on thedeer’s feeding habit in the reserve from 1985 to 1988,we discovered that Hainan eldi’s deer is aeuryphangous herbivore.They take various herbs as their main food and have fairly strongselectivity for woody plants,especially tending to eat the tender parts of plants and some fruits andflowers.Like other species of deer,they also like to lick the alkaline soil.This paper reports the re-search and evaluation on the feeding and choosing food characteristics of Hainan eldi’s deer,and onthe palatability of the main plants in the reserve.展开更多
Pet owner compliance is essential for the success of veterinary healthcare strategies. As some parasites are zoonotic, consistent parasite control is an integral part of the One-Health strategy. Highly palatable formu...Pet owner compliance is essential for the success of veterinary healthcare strategies. As some parasites are zoonotic, consistent parasite control is an integral part of the One-Health strategy. Highly palatable formulations help ensure compliance, as they offer a positive experience for the dog and the owner. This study was conducted to ascertain if dogs exhibited a preference between two commercially available oral formulations of broad-spectrum endectoparasiticides, NexGard Spectra (afoxolaner and milbemycin oxime) and Simparica Trio (sarolaner, moxidectin and pyrantel). For four consecutive days, 100 healthy dogs were offered both products and consumption was recorded. If one product was more consumed than the other, it was defined as the preferred product. No adverse event was recorded throughout the study. A total of 358 chewable tablets were consumed over four study days;78.5% of dogs voluntarily consumed NexGard Spectra (281 chews), while 21.5% of dogs voluntarily consumed Simparica Trio (77 chews, <i>p</i> < 0.01). Among 75 dogs which demonstrated a preference for a product, significantly more dogs preferred NexGard Spectra (94.7%) compared to Simparica Trio (5.3%) (<i>p</i> < 2.2 × 10<sup>-16</sup>), resulting in a preference ratio of 17.75 to 1 for NexGard Spectra.展开更多
Bamboos are used extensively for a variety of purposes,and many new species have been introduced to the northwestern Himalaya.However,their potential as a fodder species has not been investigated.Six bamboo species,na...Bamboos are used extensively for a variety of purposes,and many new species have been introduced to the northwestern Himalaya.However,their potential as a fodder species has not been investigated.Six bamboo species,namely Dendrocalamus hamiltonii Gamble,Dendrocalamus asper(Schult.and Schult.f.)Backer ex K.Heyne,Melocanna baccifera(Roxb.)Kurz,Phyllostachys aurea Rivie′re and C.Rivie′re,Phyllostachys bambusoides Sieb and Zucc.and Phyllostachys pubescens(Pradelle)Mazel ex J.Houz.were evaluated for their nutritional value,relative palatability and best lopping time.Dry matter(DM),ether extract(EE),and crude fibre varied from(37.0-67.7)%,(4.7-7.6),and(22.1-37.9)%,respectively.Values of crude protein ranged from(12.2-17.1)%,total ash(TA)from(11.8-21.5)%,acid insoluble ash(AIA)from(0.3-0.5)%,nitrogen free extract from(31.1-40.8)%,carbohydrates from(57.0-69.0)%,organic matter(OM)from(78.5-88.2)%,calcium from(1.7-2.3)%,phosphorus from(0.4-0.8)%,potassium from,(0.9-1.6)%,magnesium from(0.5-0.9)%,sodium from(603.7-1072.7)×10^-6 and vitamin A from(21.1-30.5)×10^-2 mg/g,respectively.D.hamiltonii had maximum values for DM,EE,TA and AIA.OM and vitamin A were highest in M.baccifera.CF and carbohydrates were maximized in P.aurea and CP in P.pubescens.All the values obtained for different bamboo species were less than maximum tolerable concentration of common feed resources of the region thereby indicating their suitability for nutrition and palatability.The contents of anti-nutritional factors,namely hydrocyanic acid and tannin ranged from(33.8-61.7)×10^-2 mg/g and(0.7-1.9)%,respectively.P.pubescens was the best species from a palatability point of view and has maximum crude protein content(17.2%),Ca(2.3%)and lowest tannin content(0.7%).The relative palatability of introduced bamboo species followed trend:P.pubescens(97.6%)[D.hamiltonii(92.5%)[P.bambusoides(81.2%)[D.asper(76.9%)[M.baccifera(75.9%)[P.aurea(73.4%).The optimum months for lopping these species for green leaves are November and December,as the nutritional value declines sharply thereafter.展开更多
It is well known that the taste of sweet solutions produces a morphine-like analgesia in both rats and human infants, and under certain conditions, possibly in human adults. To further explore whether ingestion analge...It is well known that the taste of sweet solutions produces a morphine-like analgesia in both rats and human infants, and under certain conditions, possibly in human adults. To further explore whether ingestion analgesia persists into human adulthood, the present study was the first to utilize contact heat, a method of pain induction used commonly in both behavioural and pharmacological studies with laboratory animals. Left arms of 120 university undergraduates were exposed to a hot-plate, with pain responsivity assessed both before and after consuming either nothing (control group), or foods that they rated previously as unpalatable (e.g., black olives), neutral (e.g., rice cakes), or palatable (e.g., chocolate-chip cookies). Pain responsivity was assessed with four pain measures: pain threshold, pain tolerance, and visual analogue scale (VAS) ratings of pain intensity and unpleasantness. Between-groups comparisons in 2 separate experiments revealed that women (but not men) who consumed a palatable food showed increased pain tolerance, relative to the nothing, unpalatable, or neutral groups. Collectively, these data support our previous findings that “palatability-induced analgesia” exists in human adults, at least in females. Moreover, the findings support contact heat as a suitable method for assessing ingestion analgesia to experimental pain with human adults.展开更多
Nepal produces large quantity of mandarin (Citrus reticulata Blanco) annually but faces big losses due to improper postharvest treatments. The experiment was carried out during 2012-2013 with the objective of assessin...Nepal produces large quantity of mandarin (Citrus reticulata Blanco) annually but faces big losses due to improper postharvest treatments. The experiment was carried out during 2012-2013 with the objective of assessing the effect of different postharvest treatments on quality and shelf life of mandarin. The postharvest treatments were: wax emulsion at 10%, bavistin at 0.1%, wax at 10% with bavistin at 0.1%, calcium chloride at 1%, Jeevatu at 5% along with untreated fruits as a control. The experiment was conducted for four weeks of storage at ambient condition in Nepal Agricultural Research Council, Khumaltar, Kathmandu. Wax in combination with bavistin was found as the most effective in reducing the physiological loss in weight, whereas bavistin proved to reduce decay loss up to four weeks of storage. The fruits treated with wax alone and with combination of bavistin retained maximum firmness, juice percentage, vitamin C and palatability rating during the storage. The minimum total soluble solid and maximum titrable acidity were recorded in the fruits treated with wax plus bavistin. The present findings indicate that mandarin can be stored up to four weeks when treated with wax as well as wax with bavistin in the condition with 14°C - 18°C temperature and 45% - 73% relative humidity.展开更多
Fleas and ticks are major ectoparasites of dogs globally. Their control is based on regular treatments with ectoparasiticides, which represent the most im<span>portant part of veterinary drugs </span><s...Fleas and ticks are major ectoparasites of dogs globally. Their control is based on regular treatments with ectoparasiticides, which represent the most im<span>portant part of veterinary drugs </span><span style="font-family:;" "="">worth</span><span style="font-family:;" "=""> around 3 billion Euros per year. In </span><span style="font-family:;" "="">many <span>parts of the world, dogs are also at risk of infection by endoparasites like</span> <span>heartworm, eyeworm, and lungworm. In these areas, endectoparasiticide</span> formulations are used to prevent the risk of ecto- and endoparasite infections. <span>Since 2014, oral formulations of insecticidal-acaricidal drugs have been</span> launched, followed by endectoparasiticide formulation</span><span style="font-family:;" "="">s</span><span style="font-family:;" "="">. These oral formulations facilitate the treatment by the owners and are now </span><span style="font-family:;" "="">the </span><span style="font-family:;" "="">market leader</span><span style="font-family:;" "="">s</span><span style="font-family:;" "="">. Intense work has been done during their development to enhance their palatability through their consistence (hard to soft) and their flavors. Palatable oral formulations facilitate the dog-owner relationship and help ensur</span><span style="font-family:;" "="">ing</span><span style="font-family:;" "=""> compli<span>ance. The most </span><span>recent palatable formulations include isoxazoline as the ecto</span></span><span style="font-family:;" "="">-</span><span style="font-family:;" "="">parasiticide mole</span><span style="font-family:;" "="">cule. They also include anthelmintics (milbemycin oxime or moxidectin +</span><span style="font-family:;" "=""> pyrantel) to provide control of parasitic nematodes. Being very similar in term</span><span style="font-family:;" "="">s</span><span style="font-family:;" "=""> of spectrum of ac<span>tivity, any differences in palatability may be a key differentiating factor for the</span> owners. The present study was <span>conducted to verify if dogs </span><span>exhibited a preference between two endectoparasiticide oral formulations,</span> Nex<span>Gard Spectra</span></span><sup><span><span style="color:#4F4F4F;font-family:-apple-system, "font-size:16px;white-space:normal;background-color:#FFFFFF;">®</span></span></sup><span style="font-family:;" "=""> (afoxolaner and milbemycin oxime) and</span><span style="font-family:;" "=""> Credelio</span><sup><span><span style="color:#4F4F4F;font-family:-apple-system, "font-size:16px;white-space:normal;background-color:#FFFFFF;">®</span></span></sup><span style="font-family:;" "=""> Plus (lotilaner and milbemycin oxime). For four consecutive days, 100 dogs were offered the <span>choice between both products and consumption was recorded. If one prod</span>uct was more consumed than the other, it was defined as the preferred <span>product. </span></span><span style="font-family:;" "="">A </span><span style="font-family:;" "="">total of 375 chewable tablets were consumed over the four days, with a significantly higher consumption (p <</span><span style="font-family:;" "=""> 0</span><span style="font-family:;" "="">.0001) for NexGard Spectra</span><sup><span><span style="color:#4F4F4F;font-family:-apple-system, "font-size:16px;white-space:normal;background-color:#FFFFFF;">®</span></span></sup><span style="font-family:;" "=""> (272 <span>chews, 72.5%) compared to Credelio</span></span><sup><span><span style="color:#4F4F4F;font-family:-apple-system, "font-size:16px;white-space:normal;background-color:#FFFFFF;">®</span></span></sup><span style="font-family:;" "=""> Plus (103 chews, 27.5%). Seventy-six dogs showed a preference for a product amongst whom 68 preferred NexGard </span><span style="font-family:;" "="">Spectra</span><sup><span><span style="color:#4F4F4F;font-family:-apple-system, "font-size:16px;white-space:normal;background-color:#FFFFFF;">®</span></span></sup><span style="font-family:;" "=""> (89.5%) and 8 preferred Credelio</span><sup><span><span style="color:#4F4F4F;font-family:-apple-system, "font-size:16px;white-space:normal;background-color:#FFFFFF;">®</span></span></sup><span style="font-family:;" "=""> Plus</span><span style="font-family:;" "=""> (10.5%), resulting in a preference ratio of 8.5 to 1 for NexGard </span><span style="font-family:;" "="">Spectra</span><sup><span><span style="color:#4F4F4F;font-family:-apple-system, "font-size:16px;white-space:normal;background-color:#FFFFFF;">®</span></span></sup><span style="font-family:;" "=""> (</span><span style="font-family:;" "="">p <</span><span style="font-family:;" "=""> 0</span><span style="font-family:;" "="">.0001)</span><span style="font-family:;" "="">.</span>展开更多
文摘The purpose of this review is to discuss the advantages and limitations of taste sensors in the evaluation of the taste of palatability of different oral dosage forms. First, we consider some ways in which the palatability of various pharmaceutical formulations including orally disintegrating tablets(ODTs) are tested using two different taste sensors. Second, we focus on the evaluation of palatability of ODTs. We compare the usefulness of three pieces of apparatus for estimating the disintegration time of ODTs. Finally, we compare the characteristics of the two taste sensors in the evaluation of palatability of various kinds of drug formulations.
基金supported by the grants from the Project of the National Agriculture and Food Research Organization Bio-oriented Technology Research Advancement Institution in Japan(the Special Scheme to Create Dynamism in Agriculture,Forestry and Fisheries through Deploying Highly Advanced Technology)(Grant No.shoNavi1000)。
文摘To clarify the optimal water management in large-scale fields under high temperatures at the ripening period,effective water managements during this period for improvement of yield,appearance quality and palatability were investigated.Compared with intermittent irrigation and flooded irrigation,the soil temperature with saturated irrigation remained low throughout the day,and the decrease rate of the bleeding rate of hills was the lowest.These results suggested that the saturated irrigation maintained root activity.For the three irrigation types,the number of spikelets per m2 and 1000-grain weight were similar,however,saturated irrigation resulted in significantly higher rice yield due to improvement in the percentage of ripened grains.The saturated irrigation produced a high percentage of perfect rice grains and thicker brown rice grain,furthermore,the palatability of cooked rice was excellent because protein content and hardness/adhesion ratio were both low.Thus,under high-temperature ripening conditions,soil temperature was lowered and root activity was maintained when applying saturated irrigation after heading time.The results indicated that saturated irrigation is an effective countermeasure against high-temperature ripening damage.
文摘For veterinary medications administered per os, animal health companies strive to develop highly palatable dosage forms that are voluntarily accepted by animals to improve compliance and convenience. Achieving high palatability is often complex and difficult even without the presence of an active ingredient. This work compared acceptance and preference studies, as standardized methods are not established for informing formulation development or for more routine testing. Formulation development was followed by an acceptance study completed with laboratory Beagle dogs. One acceptance study and one preference study were completed in mixed breed dogs, also laboratory-housed, to gain wider representation of dog breed and age. Through these studies, we have evaluated both formulation parameters and palatability study conduct. In general, more complex palatants that have appealing taste, smell, and mouth feel enhance voluntary uptake. However, dosage forms that are too chewy may not be freely consumed even with complex palatants. The addition of aroma can entice dogs to prehend the tablet, as observed in one preference study. Preference studies in the veterinary pharmaceutical field identify the preferred first choice or first prehend, but not which product will be routinely voluntarily and fully consumed. Acceptance studies with cross-over treatment groups are used to quantify the full consumption of a dosage form when a dog is not given two choices at once. Since all dogs in acceptance studies are offered all treatment groups throughout the study, a comparison between degrees of consumption could suggest that one formulation might be preferred over another.
文摘<span style="font-family:Verdana;">The purpose of this study was to evaluate the palatability of dry syrups for pediatric use by human gustatory sensation testing and the artificial taste sensor. The bitterness intensities of dry syrups mixed with various beverages were also evaluated using the taste sensor. Twenty dry-syrup formulations of antibacterial and anti-allergic drugs containing bitter active ingredients, frequently used in pediatric medicine in Japan, were selected for testing. The main factors influencing palatability were determined by factor analysis of data from human gustatory sensation testing using the semantic differential method. It was shown that the bitterness intensity of dry syrups in water could be predicted by the artificial taste sensor. The influence of different beverages (orange juice, milk </span><span style="font-family:Verdana;">or</span><span style="font-family:Verdana;"> cocoa) mixed with the dry syrups was evaluated using the artificial taste sensor.</span><span style="font-family:;" "=""> </span><span style="font-family:Verdana;">Taste and texture were found to be the principal factors influencing the palatability of dry syrups. While the bitterness intensities of some dry syrups were increased by mixing with orange juice, the bitterness intensities of most dry syrups were decreased by mixing with milk or cocoa. This suggests that one or more constituents of milk or cocoa may reduce the bitterness intensities of dry syrups.</span>
文摘The nutritive value of rangelands in Southern Darfur, Sudan could be improved by introduction and multiplication of nutritious forbs with the objective of increasing livestock production in the area. The present study was conducted to evaluate the nutritive value and palatability of eleven range forbs collected at flowering stage from Gahzal Gawazat, Southern Darfur, Sudan using chemical analysis. The crude protein (CP) ranged from 6.8% in Oxygonum atriplicifolium with lowest digestible crude protein (DCP) 2.8% to 16.4% in Zornia diphylla with highest DCP 11.73%. The highest and the lowest crude fiber (CF) values were obtained in Commelina spp (56.4%) and Sesamum alatum (25.9%), respectively. NDF and DMI values were maximum and minimum for Zornia diphylla (44.9 and 2.67%) and Alysicarpus glumaceus (35.3 and 3.4%), respectively. The total digestible nutrients (TDN) ranged from 57.1% in Blepharis linariifolia to 69.3% in Tribulus terrestris with highest digestible energy (DE) in later while the lowest DE was obtained in Commelina spp (2.4%). The calculated in vitro organic matter digestibility (IVOMD) was highest for the Canavalia ensiformis (50.27%) and lowest value (43.17%) for Commelina spp. Zornia diphylla, Tribulus terrestris and Sesamum alatum showed highest nutritive value, while Alysicarpus glumaceus, Oldenlandia senegalensis and Chrozophora brocchiana showed highest palatability. It is concluded that these rangeland forbs are palatable and their CP and energy contents are sufficient to support different classes of livestock in South Darfur, Sudan.
文摘There is an increased need for highly palatable oral dosage forms for dogs and cats, especially in the case of regular or chronic medications. To meet this need of easy application, the original Drontal®Plus tablet, a broad-spectrum anthelminthic, was optimized using a novel formula. A field study was conducted to evaluate the palatability of this new Drontal®Plus formula in comparison to a positive control product (Milbemax®Chewable Tablets) with a well-known high palatability. The study also aimed to get a palatability claim which necessitates the conduct of appropriate studies. 150 privately owned dogs of 38 pure or mixed breeds, six months to twelve years old, and with a weight range of 5 to 50 kg were included. The study was based on a cross-over design, and a standardized acceptance test was used to evaluate and compare the palatability of the two medications. In this study 88% of dogs voluntarily consumed Drontal®Plus Treat 10 kg, and 86.7% accepted Milbemax®Chewable Tablets. In the majority of cases (IVP: 98%, CP: 95%) the tablets were taken directly from the owner’s hand. The new Drontal®Plus tablet showed a high palatability compared to the Milbemax®Chewable Tablets when used in a household study design with privately owned dogs.
文摘The intensity of the bitterness of catechins increases with increased concentration, but the taste palatability decreased in green tea extract. The aim of this study was to investigate whether a blend of tea leaf particles of various sizes would result in a good balance between catechin content and appreciable taste. The control is common tea (CT) with 6 - 10 mm long leaves. Blend tea (BT) was prepared by mixing 5 mm and 120 - 130 mm long tea leaves in a ratio of 3:2. The catechin content of hot water extracts was analyzed by HPLC, and the sensory test was conducted with 99 volunteers. In BT, the total catechin content was significantly higher than that in CT. The sensory test results revealed that BT was less bitter and had more preferable color than CT. More catechins were extracted from BT, but it tasted less bitter. Thus, the recalibration of the tea leaf particle size can result in good balance between catechin content and palatability.
文摘Incidents of soft palate injury or laceration caused by unintended movement when holding a sharp object in the mouth in the pediatric population are usually rarely reported.Here we report a case of soft palate laceration in a child due to a lollypop stick tip.
文摘Introduction: Cleft lip, palate and alveolar (CLPA) are congenital malformations of the face due to a defect in the fusion of embryonic buds during the first weeks of embryogenesis. These malformations affect the upper lip, the alveolar bone and the palate. The incidence in Africa ranges from 1/2000 to 1/500 births. Their multidisciplinary management is long and costly. Thus, the help provided by humanitarian organisations during free care campaigns is welcome. Materials and Methods: This is a retrospective descriptive study conducted from August 2014 to July 2016 in the Maxillofacial Surgery and Stomatology Department of the Treichville University Hospital in Abidjan, Côte d’Ivoire. The objective was to describe the epidemiological, clinical and therapeutic aspects of CLPA during a humanitarian campaign for free care. Results: 51 cases of CLPA were operated on. Males were involved in 54.9% of the cases, i.e. a sex ratio of 1.2. The average age of the patients at the time of the operation was 3.44 years with extremes of 3 months and 52 years. Patients with low socioeconomic status represented 84.3% of the cases. Cleft lips (31.4%) and cleft palates (33.33%) predominated. For cleft lips, unilateral forms were the most frequent (73.5%) and the left side was most often affected (59.2%). The most common surgical techniques used were MILLARD cheiloplasty for cleft lips (79.36%) and Dorrance pushback for cleft palates (78.05%). The postoperative course was simple in the majority of cases (80.47%). Patients and/or parents were satisfied with the postoperative results in over 90% of cases. Discussion: Cleft lip and palate are common. Their management by humanitarian missions through mass campaigns allows us to receive a large number of patients affected by this pathology who are treated with a high satisfaction rate. Conclusion: The characteristics of cleft lip and palate in this study are in many respects identical to those described in the literature, but with some differences specific to Africa, notably the absence of antenatal diagnosis and the advanced age at the time of treatment.
文摘Various surgical techniques and approaches have been described to repair cleft nose deformities. It is necessary to consider that since it is a congenital deformity, surgical management must consider the patient’s growth process, as well as the healing itself from the surgery. The present study aims to evaluate an alternative solution to secondary rhinology, aesthetic, and functional alterations to unilateral or bilateral cleft lift palate to minimize deformities and ensure good results. 11 patients were studied between 1995 to 2002, ten male and one female. In 8 cases, the patients had a history of cleft lip and palate on the left side, 2 patients with cleft lift palate on the right, and 1 patient with bilateral cleft lip and palate. 100% of the patients increased their naso-labial angle. This improved their appearance and structure, starting from a preoperative arithmetic mean of 39 degrees to a postoperative arithmetic mean of 96 degrees. Such intervention increased the naso-labial angle by 57 degrees. At the base of the nose, it was possible to improve the inclination of the alar line (line B) in 10 of the cases with a variation of 2 to 3 mm in relation to the perpendicular line A and only one case remained with the same inclination.
文摘Hainan eldi’s deer is a precious species of deer in the tropic zone,it is regardedas the first—class animal under protection in China.Based on all-year-round observation on thedeer’s feeding habit in the reserve from 1985 to 1988,we discovered that Hainan eldi’s deer is aeuryphangous herbivore.They take various herbs as their main food and have fairly strongselectivity for woody plants,especially tending to eat the tender parts of plants and some fruits andflowers.Like other species of deer,they also like to lick the alkaline soil.This paper reports the re-search and evaluation on the feeding and choosing food characteristics of Hainan eldi’s deer,and onthe palatability of the main plants in the reserve.
文摘Pet owner compliance is essential for the success of veterinary healthcare strategies. As some parasites are zoonotic, consistent parasite control is an integral part of the One-Health strategy. Highly palatable formulations help ensure compliance, as they offer a positive experience for the dog and the owner. This study was conducted to ascertain if dogs exhibited a preference between two commercially available oral formulations of broad-spectrum endectoparasiticides, NexGard Spectra (afoxolaner and milbemycin oxime) and Simparica Trio (sarolaner, moxidectin and pyrantel). For four consecutive days, 100 healthy dogs were offered both products and consumption was recorded. If one product was more consumed than the other, it was defined as the preferred product. No adverse event was recorded throughout the study. A total of 358 chewable tablets were consumed over four study days;78.5% of dogs voluntarily consumed NexGard Spectra (281 chews), while 21.5% of dogs voluntarily consumed Simparica Trio (77 chews, <i>p</i> < 0.01). Among 75 dogs which demonstrated a preference for a product, significantly more dogs preferred NexGard Spectra (94.7%) compared to Simparica Trio (5.3%) (<i>p</i> < 2.2 × 10<sup>-16</sup>), resulting in a preference ratio of 17.75 to 1 for NexGard Spectra.
基金supported by project from Department of Silviculture and Agroforestry,Dr.Y.S.Parmar University of Horticulture and Forestry,Solan,173 230,India
文摘Bamboos are used extensively for a variety of purposes,and many new species have been introduced to the northwestern Himalaya.However,their potential as a fodder species has not been investigated.Six bamboo species,namely Dendrocalamus hamiltonii Gamble,Dendrocalamus asper(Schult.and Schult.f.)Backer ex K.Heyne,Melocanna baccifera(Roxb.)Kurz,Phyllostachys aurea Rivie′re and C.Rivie′re,Phyllostachys bambusoides Sieb and Zucc.and Phyllostachys pubescens(Pradelle)Mazel ex J.Houz.were evaluated for their nutritional value,relative palatability and best lopping time.Dry matter(DM),ether extract(EE),and crude fibre varied from(37.0-67.7)%,(4.7-7.6),and(22.1-37.9)%,respectively.Values of crude protein ranged from(12.2-17.1)%,total ash(TA)from(11.8-21.5)%,acid insoluble ash(AIA)from(0.3-0.5)%,nitrogen free extract from(31.1-40.8)%,carbohydrates from(57.0-69.0)%,organic matter(OM)from(78.5-88.2)%,calcium from(1.7-2.3)%,phosphorus from(0.4-0.8)%,potassium from,(0.9-1.6)%,magnesium from(0.5-0.9)%,sodium from(603.7-1072.7)×10^-6 and vitamin A from(21.1-30.5)×10^-2 mg/g,respectively.D.hamiltonii had maximum values for DM,EE,TA and AIA.OM and vitamin A were highest in M.baccifera.CF and carbohydrates were maximized in P.aurea and CP in P.pubescens.All the values obtained for different bamboo species were less than maximum tolerable concentration of common feed resources of the region thereby indicating their suitability for nutrition and palatability.The contents of anti-nutritional factors,namely hydrocyanic acid and tannin ranged from(33.8-61.7)×10^-2 mg/g and(0.7-1.9)%,respectively.P.pubescens was the best species from a palatability point of view and has maximum crude protein content(17.2%),Ca(2.3%)and lowest tannin content(0.7%).The relative palatability of introduced bamboo species followed trend:P.pubescens(97.6%)[D.hamiltonii(92.5%)[P.bambusoides(81.2%)[D.asper(76.9%)[M.baccifera(75.9%)[P.aurea(73.4%).The optimum months for lopping these species for green leaves are November and December,as the nutritional value declines sharply thereafter.
文摘It is well known that the taste of sweet solutions produces a morphine-like analgesia in both rats and human infants, and under certain conditions, possibly in human adults. To further explore whether ingestion analgesia persists into human adulthood, the present study was the first to utilize contact heat, a method of pain induction used commonly in both behavioural and pharmacological studies with laboratory animals. Left arms of 120 university undergraduates were exposed to a hot-plate, with pain responsivity assessed both before and after consuming either nothing (control group), or foods that they rated previously as unpalatable (e.g., black olives), neutral (e.g., rice cakes), or palatable (e.g., chocolate-chip cookies). Pain responsivity was assessed with four pain measures: pain threshold, pain tolerance, and visual analogue scale (VAS) ratings of pain intensity and unpleasantness. Between-groups comparisons in 2 separate experiments revealed that women (but not men) who consumed a palatable food showed increased pain tolerance, relative to the nothing, unpalatable, or neutral groups. Collectively, these data support our previous findings that “palatability-induced analgesia” exists in human adults, at least in females. Moreover, the findings support contact heat as a suitable method for assessing ingestion analgesia to experimental pain with human adults.
文摘Nepal produces large quantity of mandarin (Citrus reticulata Blanco) annually but faces big losses due to improper postharvest treatments. The experiment was carried out during 2012-2013 with the objective of assessing the effect of different postharvest treatments on quality and shelf life of mandarin. The postharvest treatments were: wax emulsion at 10%, bavistin at 0.1%, wax at 10% with bavistin at 0.1%, calcium chloride at 1%, Jeevatu at 5% along with untreated fruits as a control. The experiment was conducted for four weeks of storage at ambient condition in Nepal Agricultural Research Council, Khumaltar, Kathmandu. Wax in combination with bavistin was found as the most effective in reducing the physiological loss in weight, whereas bavistin proved to reduce decay loss up to four weeks of storage. The fruits treated with wax alone and with combination of bavistin retained maximum firmness, juice percentage, vitamin C and palatability rating during the storage. The minimum total soluble solid and maximum titrable acidity were recorded in the fruits treated with wax plus bavistin. The present findings indicate that mandarin can be stored up to four weeks when treated with wax as well as wax with bavistin in the condition with 14°C - 18°C temperature and 45% - 73% relative humidity.
文摘Fleas and ticks are major ectoparasites of dogs globally. Their control is based on regular treatments with ectoparasiticides, which represent the most im<span>portant part of veterinary drugs </span><span style="font-family:;" "="">worth</span><span style="font-family:;" "=""> around 3 billion Euros per year. In </span><span style="font-family:;" "="">many <span>parts of the world, dogs are also at risk of infection by endoparasites like</span> <span>heartworm, eyeworm, and lungworm. In these areas, endectoparasiticide</span> formulations are used to prevent the risk of ecto- and endoparasite infections. <span>Since 2014, oral formulations of insecticidal-acaricidal drugs have been</span> launched, followed by endectoparasiticide formulation</span><span style="font-family:;" "="">s</span><span style="font-family:;" "="">. These oral formulations facilitate the treatment by the owners and are now </span><span style="font-family:;" "="">the </span><span style="font-family:;" "="">market leader</span><span style="font-family:;" "="">s</span><span style="font-family:;" "="">. Intense work has been done during their development to enhance their palatability through their consistence (hard to soft) and their flavors. Palatable oral formulations facilitate the dog-owner relationship and help ensur</span><span style="font-family:;" "="">ing</span><span style="font-family:;" "=""> compli<span>ance. The most </span><span>recent palatable formulations include isoxazoline as the ecto</span></span><span style="font-family:;" "="">-</span><span style="font-family:;" "="">parasiticide mole</span><span style="font-family:;" "="">cule. They also include anthelmintics (milbemycin oxime or moxidectin +</span><span style="font-family:;" "=""> pyrantel) to provide control of parasitic nematodes. Being very similar in term</span><span style="font-family:;" "="">s</span><span style="font-family:;" "=""> of spectrum of ac<span>tivity, any differences in palatability may be a key differentiating factor for the</span> owners. The present study was <span>conducted to verify if dogs </span><span>exhibited a preference between two endectoparasiticide oral formulations,</span> Nex<span>Gard Spectra</span></span><sup><span><span style="color:#4F4F4F;font-family:-apple-system, "font-size:16px;white-space:normal;background-color:#FFFFFF;">®</span></span></sup><span style="font-family:;" "=""> (afoxolaner and milbemycin oxime) and</span><span style="font-family:;" "=""> Credelio</span><sup><span><span style="color:#4F4F4F;font-family:-apple-system, "font-size:16px;white-space:normal;background-color:#FFFFFF;">®</span></span></sup><span style="font-family:;" "=""> Plus (lotilaner and milbemycin oxime). For four consecutive days, 100 dogs were offered the <span>choice between both products and consumption was recorded. If one prod</span>uct was more consumed than the other, it was defined as the preferred <span>product. </span></span><span style="font-family:;" "="">A </span><span style="font-family:;" "="">total of 375 chewable tablets were consumed over the four days, with a significantly higher consumption (p <</span><span style="font-family:;" "=""> 0</span><span style="font-family:;" "="">.0001) for NexGard Spectra</span><sup><span><span style="color:#4F4F4F;font-family:-apple-system, "font-size:16px;white-space:normal;background-color:#FFFFFF;">®</span></span></sup><span style="font-family:;" "=""> (272 <span>chews, 72.5%) compared to Credelio</span></span><sup><span><span style="color:#4F4F4F;font-family:-apple-system, "font-size:16px;white-space:normal;background-color:#FFFFFF;">®</span></span></sup><span style="font-family:;" "=""> Plus (103 chews, 27.5%). Seventy-six dogs showed a preference for a product amongst whom 68 preferred NexGard </span><span style="font-family:;" "="">Spectra</span><sup><span><span style="color:#4F4F4F;font-family:-apple-system, "font-size:16px;white-space:normal;background-color:#FFFFFF;">®</span></span></sup><span style="font-family:;" "=""> (89.5%) and 8 preferred Credelio</span><sup><span><span style="color:#4F4F4F;font-family:-apple-system, "font-size:16px;white-space:normal;background-color:#FFFFFF;">®</span></span></sup><span style="font-family:;" "=""> Plus</span><span style="font-family:;" "=""> (10.5%), resulting in a preference ratio of 8.5 to 1 for NexGard </span><span style="font-family:;" "="">Spectra</span><sup><span><span style="color:#4F4F4F;font-family:-apple-system, "font-size:16px;white-space:normal;background-color:#FFFFFF;">®</span></span></sup><span style="font-family:;" "=""> (</span><span style="font-family:;" "="">p <</span><span style="font-family:;" "=""> 0</span><span style="font-family:;" "="">.0001)</span><span style="font-family:;" "="">.</span>
