Objective:To evaluate the protective effect of ethanol extract of Mollugo nudicaulis(M.nudicaulis) against perchloroethylene-induced hepatotoxicity.Methods:The hepatoprotective activity of the ethanol extract of M.nud...Objective:To evaluate the protective effect of ethanol extract of Mollugo nudicaulis(M.nudicaulis) against perchloroethylene-induced hepatotoxicity.Methods:The hepatoprotective activity of the ethanol extract of M.nudicaulis(200 mg/kg body wt) was studied in percholoroethylene (1 000 mg/kg body wt) induced hepatotoxicity in Wistar albino rats.The serum levels of AST, ALT,ALP,bilirubin and the liver content of SOD,CAT,GPx,GST,CSH,vitamin C were assessed to evaluate the hepatoprotective and antioxidant activities of the extract.The activity of the extract was compared with silymarin,a standard reference drug.In addition,serum urea,uric acid and creatinine levels were measured to evaluate the kidney function.The histopathological examination of the liver tissues was observed to support the biochemical parameters.Results: The results revealed that the extract significantly(P【0.05) restored the serum levels of AST,ALT, ALP,bilinibin and significantly(P【0.05) increased the antioxidant enzymes SOD,CAT,GPx,GST, GSH,vitamin C in perchloroethylene-induced rats to its normalcy.The biochemical observations were suppoited by the histopathological studies of the liver tissues.Conclusions:The results led to the conclusion that M.nudicaulis possess hepatoprotective and antioxidant activites against perchloroethylene-induced hepatotoxicity in rats.展开更多
Chlorinated hydrocarbons are widely detected in groundwater, but conventional removal methodologies are not time-and-cost effective. With the development of iron reducing technology in recent years, research on nano-i...Chlorinated hydrocarbons are widely detected in groundwater, but conventional removal methodologies are not time-and-cost effective. With the development of iron reducing technology in recent years, research on nano-iron and nano-bimetal has become a hot spot. The paper presents the results of impact factors on perchloroethylene （PCE） removal by nano-Ni/Fe method. The data show that the reaction rate of unexposed nano-Ni/Fe is 4 times higher than exposed one; and temperature is one of the important controlling factors. Reaction rate constant KSA increases by 2-3 times with every 10℃ increment of temperature. Within a specific range, higher Ni/Fe ratio favors dechlorination process. When the Ni/Fe is 8%, the dechlorination process reaches the highest rate. Dissoved oxygen in the solution does not favor the degradation of chlorinated hydrocarbons.展开更多
文摘Objective:To evaluate the protective effect of ethanol extract of Mollugo nudicaulis(M.nudicaulis) against perchloroethylene-induced hepatotoxicity.Methods:The hepatoprotective activity of the ethanol extract of M.nudicaulis(200 mg/kg body wt) was studied in percholoroethylene (1 000 mg/kg body wt) induced hepatotoxicity in Wistar albino rats.The serum levels of AST, ALT,ALP,bilirubin and the liver content of SOD,CAT,GPx,GST,CSH,vitamin C were assessed to evaluate the hepatoprotective and antioxidant activities of the extract.The activity of the extract was compared with silymarin,a standard reference drug.In addition,serum urea,uric acid and creatinine levels were measured to evaluate the kidney function.The histopathological examination of the liver tissues was observed to support the biochemical parameters.Results: The results revealed that the extract significantly(P【0.05) restored the serum levels of AST,ALT, ALP,bilinibin and significantly(P【0.05) increased the antioxidant enzymes SOD,CAT,GPx,GST, GSH,vitamin C in perchloroethylene-induced rats to its normalcy.The biochemical observations were suppoited by the histopathological studies of the liver tissues.Conclusions:The results led to the conclusion that M.nudicaulis possess hepatoprotective and antioxidant activites against perchloroethylene-induced hepatotoxicity in rats.
基金the National Natural Science Foundation of China （40572146） the project （2002BA906A28-1B） from the Ministry of Science and Technology of China.
文摘Chlorinated hydrocarbons are widely detected in groundwater, but conventional removal methodologies are not time-and-cost effective. With the development of iron reducing technology in recent years, research on nano-iron and nano-bimetal has become a hot spot. The paper presents the results of impact factors on perchloroethylene （PCE） removal by nano-Ni/Fe method. The data show that the reaction rate of unexposed nano-Ni/Fe is 4 times higher than exposed one; and temperature is one of the important controlling factors. Reaction rate constant KSA increases by 2-3 times with every 10℃ increment of temperature. Within a specific range, higher Ni/Fe ratio favors dechlorination process. When the Ni/Fe is 8%, the dechlorination process reaches the highest rate. Dissoved oxygen in the solution does not favor the degradation of chlorinated hydrocarbons.
