Introduction: Canine mammary gland tumor is the most common type of neoplasia in non-ovariectomized bitches. Approximately 50% of tumors are malignant. Neoplasms originating from the mammary gland represent the most c...Introduction: Canine mammary gland tumor is the most common type of neoplasia in non-ovariectomized bitches. Approximately 50% of tumors are malignant. Neoplasms originating from the mammary gland represent the most common neoplastic disease in canines in Veterinary Medicine. Aim: Relate the expression of the receptor to progesterone (PR) with the tumor stage of canine mammary carcinoma. Material and Methods: Analytical-cross-sectional study, samples of paraffinized tumor tissue obtained from 30 canine patients with breast cancer were used. The expression of PR was performed by immunohistochemical labeling, using murine anti-PR (anti-PR Biocare brand). A descriptive analysis was carried out with the results using the SPSS program. Results: The predominant histological subtype of breast cancer was tubular carcinoma with 12 patients, followed by papillary cystic carcinoma with 6 patients, solid carcinoma 5, carcinosarcoma 4 and comedocarcinoma 3. There was a significant trend between breast cancer subtypes, histological grade G1. Among the histopathological findings, the degree of invasion is related to the presence of tumor cells in adjacent lymph nodes, which is why it is a prognostic indicator. The expression of PR in the tumor tissue samples it was 42.8% positive versus 57.14% negative, of which 75% correspond to G1, 8.3% to G2 and 16.6% to G3. With respect to the relationship of the expression of PR vs type of tumor, it was found that 50% correspond to tubular carcinoma, 33.3% to papillary cystic carcinoma, 8.3% to solid carcinoma and 8.3% to comedocarcinoma. Conclusion: The hormone receptor was negative in more than half of the patients and histological grade is significantly associated with tumor subtypes, this study emphasizes the need to introduce receptor testing into our routine clinical practice to offer the best treatment for breast cancer.展开更多
BACKGROUND Subchorionic hematoma(SCH)is a common complication in early pregnancy characterized by the accumulation of blood between the uterine wall and the chorionic membrane.SCH can lead to adverse pregnancy outcome...BACKGROUND Subchorionic hematoma(SCH)is a common complication in early pregnancy characterized by the accumulation of blood between the uterine wall and the chorionic membrane.SCH can lead to adverse pregnancy outcomes such as miscarriage,preterm birth,and other complications.Early detection and accurate assessment of SCH are crucial for appropriate management and improved pregnancy outcomes.AIM To evaluate the diagnostic efficacy of virtual organ computer-assisted analysis(VOCAL)in measuring the volume ratio of SCH to gestational sac(GS)combined with serum progesterone on early pregnancy outcomes in patients with SCH.METHODS A total of 153 patients with SCH in their first-trimester pregnancies between 6 and 11 wk were enrolled.All patients were followed up until a gestational age of 20 wk.The parameters of transvaginal two-dimensional ultrasound,including the circumference of SCH(Cs),surface area of SCH(Ss),circumference of GS(Cg),and surface area of GS(Sg),and the parameters of VOCAL with transvaginal three-dimensional ultrasound,including the three-dimensional volume of SCH(3DVs)and GS(3DVg),were recorded.The size of the SCH and its ratio to the GS size(Cs/Cg,Ss/Sg,3DVs/3DVg)were recorded and compared.RESULTS Compared with those in the normal pregnancy group,the adverse pregnancy group had higher Cs/Cg,Ss/Sg,and 3DVs/3DVg ratios(P<0.05).When 3DVs/3DVg was 0.220,the highest predictive performance predicted adverse pregnancy outcomes,resulting in an AUC of 0.767,and the sensitivity,specificity were 70.2%,75%respectively.VOCAL measuring 3DVs/3DVg combined with serum progesterone gave a diagnostic AUC of 0.824 for early pregnancy outcome in SCH patients,with a high sensitivity of 82.1%and a specificity of 72.1%,which showed a significant difference between AUC.CONCLUSION VOCAL-measured 3DVs/3DVg effectively quantifies the severity of SCH,while combined serum progesterone better predicts adverse pregnancy outcomes.展开更多
随着分布式清洁能源发电技术的发展,传统电力用户逐渐转变为电能产消者,并可采用合作联盟形式参与电力P2P(peer to peer)交易,促进分布式清洁能源就地消纳。该文通过从源端和传输端分别核算碳减排量的方法,构建一类考虑经济效益和环境...随着分布式清洁能源发电技术的发展,传统电力用户逐渐转变为电能产消者,并可采用合作联盟形式参与电力P2P(peer to peer)交易,促进分布式清洁能源就地消纳。该文通过从源端和传输端分别核算碳减排量的方法,构建一类考虑经济效益和环境效益的社会福利函数,研究分布式电能产消者通过合作联盟形式实现社会福利最大化的途径。设计一种依据产消者对联盟社会福利贡献值分配合作剩余的机制,激励产消者合作的积极性以维持联盟的稳定。算例分析表明:相较于P2G(peer-to-grid)交易和非合作P2P交易,产消者以合作联盟方式参与电力P2P交易的社会福利分别提升了62.62%、33.79%。因此,以市场化的方式组建合作联盟参与电力P2P交易并合理分配利益,可挖掘分布式清洁能源就地消纳的潜力,促进能源消费的绿色低碳转型。展开更多
目前电磁时间反演(electromagnetic time reversal,EMTR)多应用在单一线路故障定位,且现有判据在高阻抗接地情况下效果不理想。针对上述问题,基于EMTR故障定位原理和均匀传输线理论推导了传播过程中线路故障信号与测量信号的传递函数,...目前电磁时间反演(electromagnetic time reversal,EMTR)多应用在单一线路故障定位,且现有判据在高阻抗接地情况下效果不理想。针对上述问题,基于EMTR故障定位原理和均匀传输线理论推导了传播过程中线路故障信号与测量信号的传递函数,根据传递函数的相关性提出了P范数判据。利用ATP-EMTP搭建10 kV配电网线路,对比了2范数与P范数判据在复杂配电网中的定位性能,并验证了所提判据在混合配电网线路的适用性。最后,分析了配电网发生低阻抗及高阻抗接地故障下P范数判据的鲁棒性。仿真结果表明,该方法在过渡电阻高达3 kΩ的情况下能准确定位,且定位精度高,受噪声、故障类型和采样频率的影响小。展开更多
1958—1999年,在广东省佛山市南海区西樵镇一带发现了众多记录了史前人类活动的石器地点,石器中包括双肩石器和细石器。迄今为止,“西樵山遗址”被认定是4—7 ka B P的大型新石器时期采石场和加工场。2011—2022年,笔者经多次地质遗迹...1958—1999年,在广东省佛山市南海区西樵镇一带发现了众多记录了史前人类活动的石器地点,石器中包括双肩石器和细石器。迄今为止,“西樵山遗址”被认定是4—7 ka B P的大型新石器时期采石场和加工场。2011—2022年,笔者经多次地质遗迹和地质环境调查,在西樵山东南麓富贤村北面发现了良好的第四纪地层剖面。地质探槽剖面测量和地质年代学研究表明:富贤地点存在2套原始沉积地层:上部为第四纪全新世沼泽相地层,AMS14C校正年龄为5052—5409 a B P;下部为第四纪晚更新世冲积-洪积相地层,AMS14C校正年龄为38420—40502 a B P,OSL (光释光)年龄为41.977—43.796 ka B P;在晚更新世地层中发现2层含旧石器层,下部A1层主要石器类型有较大型刮削器、尖刃器、舌型刃器及小型石片工具,如各类刮削器、锯齿刃器、凹缺器、石刀、使用石片、石核等,包括带铤斧型小石刀;上部A2层明显出现更多石刀类型且常常附带修背和修铤工作,其中一件用于生产细小长石片的原始楔形石核引人关注。据平均沉积速率计算,下部A1石器层年龄为46.511—47.325 ka B P,上部A2石器层年龄为41.977—42.167 ka B P;距今大于5 ka的全新世沉积物中的石制品数量虽少,但器物类型仍具有明显继承性与发展性特点。本文的发现更新并延伸了西樵山国家地质公园和“西樵山文化”的内涵,首次突破了珠江三角洲地区有确切年代的晚更新世旧石器遗存的纪录,追踪到大约40—50 ka现代人在华南沿海的足迹,揭示了同期石器工业的面貌及其文化内涵的发展特征和演变。研究表明,在MIS3间冰段相对湿热时期以及MIS2相对干冷阶段,富贤地点的古人类面临环境变化的挑战而开启了新的生计模式,这对于揭示现代人对全球和区域环境变化的响应与适应的科学问题具有重要意义。展开更多
文摘Introduction: Canine mammary gland tumor is the most common type of neoplasia in non-ovariectomized bitches. Approximately 50% of tumors are malignant. Neoplasms originating from the mammary gland represent the most common neoplastic disease in canines in Veterinary Medicine. Aim: Relate the expression of the receptor to progesterone (PR) with the tumor stage of canine mammary carcinoma. Material and Methods: Analytical-cross-sectional study, samples of paraffinized tumor tissue obtained from 30 canine patients with breast cancer were used. The expression of PR was performed by immunohistochemical labeling, using murine anti-PR (anti-PR Biocare brand). A descriptive analysis was carried out with the results using the SPSS program. Results: The predominant histological subtype of breast cancer was tubular carcinoma with 12 patients, followed by papillary cystic carcinoma with 6 patients, solid carcinoma 5, carcinosarcoma 4 and comedocarcinoma 3. There was a significant trend between breast cancer subtypes, histological grade G1. Among the histopathological findings, the degree of invasion is related to the presence of tumor cells in adjacent lymph nodes, which is why it is a prognostic indicator. The expression of PR in the tumor tissue samples it was 42.8% positive versus 57.14% negative, of which 75% correspond to G1, 8.3% to G2 and 16.6% to G3. With respect to the relationship of the expression of PR vs type of tumor, it was found that 50% correspond to tubular carcinoma, 33.3% to papillary cystic carcinoma, 8.3% to solid carcinoma and 8.3% to comedocarcinoma. Conclusion: The hormone receptor was negative in more than half of the patients and histological grade is significantly associated with tumor subtypes, this study emphasizes the need to introduce receptor testing into our routine clinical practice to offer the best treatment for breast cancer.
文摘BACKGROUND Subchorionic hematoma(SCH)is a common complication in early pregnancy characterized by the accumulation of blood between the uterine wall and the chorionic membrane.SCH can lead to adverse pregnancy outcomes such as miscarriage,preterm birth,and other complications.Early detection and accurate assessment of SCH are crucial for appropriate management and improved pregnancy outcomes.AIM To evaluate the diagnostic efficacy of virtual organ computer-assisted analysis(VOCAL)in measuring the volume ratio of SCH to gestational sac(GS)combined with serum progesterone on early pregnancy outcomes in patients with SCH.METHODS A total of 153 patients with SCH in their first-trimester pregnancies between 6 and 11 wk were enrolled.All patients were followed up until a gestational age of 20 wk.The parameters of transvaginal two-dimensional ultrasound,including the circumference of SCH(Cs),surface area of SCH(Ss),circumference of GS(Cg),and surface area of GS(Sg),and the parameters of VOCAL with transvaginal three-dimensional ultrasound,including the three-dimensional volume of SCH(3DVs)and GS(3DVg),were recorded.The size of the SCH and its ratio to the GS size(Cs/Cg,Ss/Sg,3DVs/3DVg)were recorded and compared.RESULTS Compared with those in the normal pregnancy group,the adverse pregnancy group had higher Cs/Cg,Ss/Sg,and 3DVs/3DVg ratios(P<0.05).When 3DVs/3DVg was 0.220,the highest predictive performance predicted adverse pregnancy outcomes,resulting in an AUC of 0.767,and the sensitivity,specificity were 70.2%,75%respectively.VOCAL measuring 3DVs/3DVg combined with serum progesterone gave a diagnostic AUC of 0.824 for early pregnancy outcome in SCH patients,with a high sensitivity of 82.1%and a specificity of 72.1%,which showed a significant difference between AUC.CONCLUSION VOCAL-measured 3DVs/3DVg effectively quantifies the severity of SCH,while combined serum progesterone better predicts adverse pregnancy outcomes.
文摘随着分布式清洁能源发电技术的发展,传统电力用户逐渐转变为电能产消者,并可采用合作联盟形式参与电力P2P(peer to peer)交易,促进分布式清洁能源就地消纳。该文通过从源端和传输端分别核算碳减排量的方法,构建一类考虑经济效益和环境效益的社会福利函数,研究分布式电能产消者通过合作联盟形式实现社会福利最大化的途径。设计一种依据产消者对联盟社会福利贡献值分配合作剩余的机制,激励产消者合作的积极性以维持联盟的稳定。算例分析表明:相较于P2G(peer-to-grid)交易和非合作P2P交易,产消者以合作联盟方式参与电力P2P交易的社会福利分别提升了62.62%、33.79%。因此,以市场化的方式组建合作联盟参与电力P2P交易并合理分配利益,可挖掘分布式清洁能源就地消纳的潜力,促进能源消费的绿色低碳转型。
文摘目前电磁时间反演(electromagnetic time reversal,EMTR)多应用在单一线路故障定位,且现有判据在高阻抗接地情况下效果不理想。针对上述问题,基于EMTR故障定位原理和均匀传输线理论推导了传播过程中线路故障信号与测量信号的传递函数,根据传递函数的相关性提出了P范数判据。利用ATP-EMTP搭建10 kV配电网线路,对比了2范数与P范数判据在复杂配电网中的定位性能,并验证了所提判据在混合配电网线路的适用性。最后,分析了配电网发生低阻抗及高阻抗接地故障下P范数判据的鲁棒性。仿真结果表明,该方法在过渡电阻高达3 kΩ的情况下能准确定位,且定位精度高,受噪声、故障类型和采样频率的影响小。
文摘1958—1999年,在广东省佛山市南海区西樵镇一带发现了众多记录了史前人类活动的石器地点,石器中包括双肩石器和细石器。迄今为止,“西樵山遗址”被认定是4—7 ka B P的大型新石器时期采石场和加工场。2011—2022年,笔者经多次地质遗迹和地质环境调查,在西樵山东南麓富贤村北面发现了良好的第四纪地层剖面。地质探槽剖面测量和地质年代学研究表明:富贤地点存在2套原始沉积地层:上部为第四纪全新世沼泽相地层,AMS14C校正年龄为5052—5409 a B P;下部为第四纪晚更新世冲积-洪积相地层,AMS14C校正年龄为38420—40502 a B P,OSL (光释光)年龄为41.977—43.796 ka B P;在晚更新世地层中发现2层含旧石器层,下部A1层主要石器类型有较大型刮削器、尖刃器、舌型刃器及小型石片工具,如各类刮削器、锯齿刃器、凹缺器、石刀、使用石片、石核等,包括带铤斧型小石刀;上部A2层明显出现更多石刀类型且常常附带修背和修铤工作,其中一件用于生产细小长石片的原始楔形石核引人关注。据平均沉积速率计算,下部A1石器层年龄为46.511—47.325 ka B P,上部A2石器层年龄为41.977—42.167 ka B P;距今大于5 ka的全新世沉积物中的石制品数量虽少,但器物类型仍具有明显继承性与发展性特点。本文的发现更新并延伸了西樵山国家地质公园和“西樵山文化”的内涵,首次突破了珠江三角洲地区有确切年代的晚更新世旧石器遗存的纪录,追踪到大约40—50 ka现代人在华南沿海的足迹,揭示了同期石器工业的面貌及其文化内涵的发展特征和演变。研究表明,在MIS3间冰段相对湿热时期以及MIS2相对干冷阶段,富贤地点的古人类面临环境变化的挑战而开启了新的生计模式,这对于揭示现代人对全球和区域环境变化的响应与适应的科学问题具有重要意义。
