期刊文献+
共找到26篇文章
< 1 2 >
每页显示 20 50 100
Fixed-Dose Combination (FDC) Formulation of Quinine Sulphate-Doxycycline (Qidox) for Malaria Therapy
1
作者 Widyati Widyati Timbul Partogi H. Simorangkir +3 位作者 Syahrul Tuba Taufiq Riyadi Yuda Prasetya Nugraha William Ratna Prawira 《Journal of Biosciences and Medicines》 CAS 2023年第1期184-194,共11页
Background: One of the deadliest parasite infections is malaria. A combination of quinine sulphate and doxycycline is another therapeutic option for malaria that is resistant to chloroquine and is anticipated to be ab... Background: One of the deadliest parasite infections is malaria. A combination of quinine sulphate and doxycycline is another therapeutic option for malaria that is resistant to chloroquine and is anticipated to be able to both combat the issue of anti-malarial medication resistance as well as the compliance to malaria therapy that is still raging in certain locations of Indonesia. Aim: This study will focus on evaluating the possibility of interaction between quinine sulphate and doxycycline followed by formulating the fixed-dose combination of both active pharmaceutical ingredients. Method: The study was designed as a laboratory experiment and applied some examinations. The examination from the organoleptic test of active pharmaceutical ingredients powder, crystallography analysis, and physical analysis of fixed-dose tablet including hardness, friability, and disintegration time testing. Result: The crystallography study reported there was no physical interaction found between quinine sulphate and doxycycline. The formula found excellent tablet printability with a composition of Quinine sulphate and doxycycline (Qidox). Conclusion: quinine sulphate with doxycycline can be combined into one tablet as Fixed-Dose Combination (FDC). 展开更多
关键词 MALARIA quinine Sulphate DOXYCYCLINE FDC
下载PDF
Identification, Characterization and Evaluation of Crystal Forms of Quinine Sulphate 被引量:3
2
作者 Maninder Karan Renu Chadha +1 位作者 Kunal Chadha Poonam Arora 《Pharmacology & Pharmacy》 2012年第2期129-138,共10页
Crystal engineering concept has been utilized to modify the physico-chemical parameters of a naturally occurring alkaloid, quinine sulphate, by exploring its H-bond interactions to generate different forms. Quinine su... Crystal engineering concept has been utilized to modify the physico-chemical parameters of a naturally occurring alkaloid, quinine sulphate, by exploring its H-bond interactions to generate different forms. Quinine sulphate is found to exist in four different crystal forms. The Forms I and II depict endo/exo events suggesting conversion of metastable low melting forms to higher melting and stable form indicated by sharp melting endotherms. The low melting form IL is found to be monotropically related to high melting Form IH while low melting Form IIL is enantiotropically related to high melting Form IIH. The Form III and IV showed broad endotherms accompanied by mass loss in TGA prior to melting indicating the existence of solvatomorphism. The solvent molecules are tightly bound in the crystal lattice of the drug molecules which is shown by high values of the binding energies of the solvents in these two forms. The enthalpy of solution was found to be endothermic for all the forms which followed the order: Form O > Form II > Form III > Form I > Form IV and is further related to the lattice energy suggesting Form II to be least crystalline. The solubility for Form II was found to be highest with maximum release rate in dissolution studies. The effectiveness of new polymorphic forms was confirmed by performing in vivo antimalarial activity against P. berghei infection. The studies have shown an increase in antimalarial activity of Form IV concluding a successful development of new polymorphic form. 展开更多
关键词 quinine Sulphate ENTHALPY POLYMORPHS SOLVATES CRYSTALS
下载PDF
Comparative study of chloroquine and quinine on malaria rodents and their effects on the mouse testis 被引量:1
3
作者 Esmail Abolghasemi Seyed Hassan Moosa-Kazemi +2 位作者 Maryam Davoudi Ahmad Reisi Mohammad Taghi Satvat 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2012年第4期311-314,共4页
Objective:To evaluate the effects of quinine and chloroquine against mole mice infected with Plasmodium berghei and their adverse effects on the mice testes.Methods:In this study,48 adult male mice,(20-23 g).aged 8 to... Objective:To evaluate the effects of quinine and chloroquine against mole mice infected with Plasmodium berghei and their adverse effects on the mice testes.Methods:In this study,48 adult male mice,(20-23 g).aged 8 to 12 weeks were divided into four groups.This study was carried out from December 2009 until May 2010 in the School of Public Health,Tehran University of Medical Sciences.Results:The results showed that 58.33%of mice treated with chloroquine were completely recovered.Parasitemia was 4%on day 8 when compared to that on day 0,whereas it was 9%on day 9.There was no orchitis found in this group.The mortality of mice after exposing to quinine on day 5 was 8.3%,whereas from day 10 to day 14 it was 91.7%.We found 73%orchitis occurred in quinine treated group.There was a significant difference between quinine and chloroquine effects on the parasite and also mice testes(P<0.05).Conclusions:In this study,It can be concluded that male mice have full resistance to the quinine.Quinine does not only make male mice recover completely,but also cause inflammation on mice testicles tissue. 展开更多
关键词 quinine CHLOROQUINE ORCHITIS PLASMODIUM BERGHEI
下载PDF
Benefits of Artesunate versus Quinine in the Treatment of Children with Severe Malaria at the National University Teaching Hospital of Cotonou 被引量:1
4
作者 Godonou Gratien Sagbo Laeticia Zohoun +5 位作者 Gilles Bognon Joseph Agossou Caroline Padonou Yévèdo Tohodjèdé Florence Alihonou Blaise Ayivi 《Open Journal of Pediatrics》 2017年第3期156-163,共8页
Introduction: Severe malaria is one of the leading causes of death in Sub-Saharan African countries, and artesunate is recommended as a first-line treatment by the Word Heath Organization (WHO.). Objective: Identify t... Introduction: Severe malaria is one of the leading causes of death in Sub-Saharan African countries, and artesunate is recommended as a first-line treatment by the Word Heath Organization (WHO.). Objective: Identify the advantages of artesunate compared with quinine in the treatment of severe malaria in children. Methods and patients: This study was a cross-sectional, descriptive and analytical study focused on children hospitalized for severe malaria in the CNHU who were treated with quinine or artesunate. Findings: The hospital-based frequency rate of severe malaria in pediatric patients was estimated to be 28.3% (n = 848). One hundred five children were treated with artesunate, and 743 were treated with quinine. The mean age of the children was 47 months old. The primary signs of severity were anemia (n = 776), neurological manifestations (n = 309) and hemolysis (n = 137). The average duration of treatment was 1.95 days for artesunate versus 2.45 days for quinine, and the difference was statistically significant (p = 0.001). The average length of stay (ALOS) in the hospital was 5 days for the artesunate group versus 5.75 days for the quinine group, and the difference was statistically significant (p < 0.001). Six of the children who received artesunate died, whereas 24 children who treated with quinine died. The total average cost of healthcare was 50,600 FCFA (77 euros) per child treated with artesunate versus 57,100 FCFA (87 euros) per child treated with quinine. Conclusion: The treatment of severe malaria with artesunate is superior to quinine-based treatment. 展开更多
关键词 SEVERE MALARIA quinine ARTESUNATE
下载PDF
Study on Adsorption Behavior of Au、Pd、Pt by Quinine Loded Resin With ICP-AES
5
作者 Liu Huai-zhi Jiang Zu-cheng +1 位作者 Wang Fu-yi Peng Tian-you 《Wuhan University Journal of Natural Sciences》 CAS 1999年第4期472-472,共1页
A new adsorbent QCR was prepared with quinine impregnated on cation exchange resin. It was found that QCR was stable in the solution of HCl(0.1~3.0 mol/L). Separation and preconcentration of noble metal ions (Au、Pd... A new adsorbent QCR was prepared with quinine impregnated on cation exchange resin. It was found that QCR was stable in the solution of HCl(0.1~3.0 mol/L). Separation and preconcentration of noble metal ions (Au、Pd、Pt) by QCR have been studied by Inductively Coupled Plasma Atomic Emission Spectronetry (ICP\|AES). More than 93% of noble metal ions were adsorbed by QCR in 0.1mol/L HCl; and the analyte could be eluted quantatively by using 2 g/L thiourea -0.1 mol/L HCl as the eluant. The adsorption selectivity to Au、Pd、Pt is good at the existence of some non\|noble ions. This method has been applied to the analysis of catalysts and anticancer drugs with satisfactory results.\; 展开更多
关键词 ICP-AES quinine ADSORBENT AU PD PT
下载PDF
NBO Analysis by ONIOM and DFT (B3LYP) Calculations of Intramolecular and Intermolecular Interactions of Artemisinin, Quinine and Thirteen Manzamenones with H2O or Alanine
6
作者 Atse Adepo Jacques Kone Soleymane +1 位作者 Diomande Sékou Et Bamba El-Hadji Sawaliho 《Journal of Materials Science and Chemical Engineering》 CAS 2022年第10期78-98,共21页
This work was undertaken to analyze intramolecular and intermolecular interactions of Manzamenones from natural bond orbitals (NBO method). For their use in the treatment of malaria, the results of these molecules are... This work was undertaken to analyze intramolecular and intermolecular interactions of Manzamenones from natural bond orbitals (NBO method). For their use in the treatment of malaria, the results of these molecules are compared to those of Artemisinin and Quinine. Manzamenones are a class of atypical fatty acids. They are isolated from a marine sponge of the genus Plakortis kenyensis. The analysis of intramolecular interactions compares the results of each molecule (Manzamenones, Artemisinin and Quinine) in the non-complexed state with those of its complex with a water molecule. Thus, for the same electron donors (i) and associated acceptors (j), the electron density (ED), stabilization energy E<sup>2</sup> related to the delocalization of i to j, the energies of the NBO orbitals ε<sub>i</sub> and ε<sub>j</sub> of the donor and acceptor, respectively, and element of the Fock matrix F<sub>i,j</sub> are determined and compared. The change in E<sup>2</sup> is used to deduce whether or not the molecule is stabilized after complex formation. These analyses allowed to match each Manzamenone to one of the two antimalarials. The intermolecular interactions were analyzed, for each molecule (Manzamenones, Artemisinin and Quinine), in two complexes. These complexes are obtained with a water molecule on the one hand and with an alanine molecule on the other hand. For these interactions, the electron donor and its electron density, the electron acceptor and its electron density as well as the donor—acceptor stabilization energy have been calculated. The ONIOM 2 method is used to study Manzamenones. Theoretical calculations were done using density functional theory (B3LYP) by combining one of the two function bases 6-31++G(d,p) and 6-31+G(d,p). 展开更多
关键词 Malaria Manzamenone ARTEMISININ quinine DFT NBO ONIOM Stability
下载PDF
Quality Control of Quinine in Pharmaceutical Forms Tablets Find East of the Democratic Republic of Congo
7
作者 Lucien Murhula Namegabe Mireille Tumusifu Kadhesi +2 位作者 Pacifique Murhula Hamuli Aladdin Ombeni Mahano Paul Brioen 《American Journal of Analytical Chemistry》 2019年第9期415-422,共8页
The present study focuses on the quality control of quinine in the compressed pharmaceutical forms circulating in eastern Democratic Republic of Congo. The analyses performed on the collected samples included disinteg... The present study focuses on the quality control of quinine in the compressed pharmaceutical forms circulating in eastern Democratic Republic of Congo. The analyses performed on the collected samples included disintegration of the tablets, identification of quinine in the formulations by color reaction methods and thin-layer chromatography. The quantitative analysis was performed by spectrophotometric and volumetric methods. The most significantly observed findings were abnormalities of release;underdosing, overdosing and absence of the active ingredient, Which brings us to the conclusion that more than 30% of the samples analyzed are of inferior quality and adulterated. 展开更多
关键词 QUALITY-CONTROL quinine TABLETS
下载PDF
Post-Quinine Bilious Hemoglobin Fever in an 8-Year-Old Child Monitored for Severe Malaria at the Yalosase Health Center, Isangi, DR Congo
8
作者 Dieudonné Lobela Bumba Issa Yakusu Issa +4 位作者 Bruce Wembolua Shinga Muyobela Kampunzu Gilbert Bokungu Isongibi Francy Baelongandi Folo Jacques Ossinga Bassandja 《Advances in Infectious Diseases》 2021年第1期1-5,共5页
It has been known since March 2013 that Artesunate is considered the gold standard treatment for severe malaria <a href="#ref1">[1]</a> <a href="#ref2">[2]</a> <a href=&q... It has been known since March 2013 that Artesunate is considered the gold standard treatment for severe malaria <a href="#ref1">[1]</a> <a href="#ref2">[2]</a> <a href="#ref3">[3]</a>. However, in our regions, the drug of choice available to treat patients with severe malaria remains quinine until today. However, frequent and sequential use of quinine is associated with the occurrence of hemoglobinuria <a href="#ref2">[2]</a>. We report a probable case of bilious hemoglobin fever (BHF) in an 8-year-old child. This was an 8-year-old child with a history of frequent and recent treatment with quinine, received in consultation for coca-cola urine emission with rapid diagnostic test (RDT) positive. In search of a particular terrain, the retroviral and syphilitic serologies were negative. Considering the context, the diagnosis of post-quinine hemoglobin bilious fever (BHF) was retained and the patient had progressed well after administration of artemisinin and its derivatives. The child was followed, on an outpatient basis, without any sequelae. It would therefore be prudent for the time being to avoid them in prophylaxis and self-medication. 展开更多
关键词 Bilious Hemoglobin Fever Severe Malaria quinine Isangi
下载PDF
Measurement and calculation of solubility of quinine in supercritical carbon dioxide
9
作者 Fatemeh Zabihi Mehrdad Mirzajanzadeh +1 位作者 Jingfu Jia Yaping Zhao 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2017年第5期641-645,共5页
Solubility of quinine in supercritical carbon dioxide(SCCO_2) was experimentally measured in the pressure range of 8 to 24 MPa, at three constant temperatures: 308.15 K, 318.15 K and 328.15 K. Measurement was carried ... Solubility of quinine in supercritical carbon dioxide(SCCO_2) was experimentally measured in the pressure range of 8 to 24 MPa, at three constant temperatures: 308.15 K, 318.15 K and 328.15 K. Measurement was carried out in a semi-dynamic system. Experimental data were correlated by iso-fugacity model(based on cubic equations of state, CEOS), Modified Mendez–Santiago–Teja(MST) and Modified Bartle semi-empirical models. Two cubic equations of state: Peng–Robinson(PR) and Dashtizadeh–Pazuki–Ghotbi–Taghikhani(DPTG) were adopted for calculation of equilibrium parameters in CEOS modeling. Interaction coefficients(k_(ij)& l_(ij)) of van der Waals(vdW) mixing rules were considered as the correlation parameters in CEOS-based modeling and their contribution to the accuracy of model was investigated. Average Absolute Relative Deviation(AARD) between correlated and experimental data was calculated and compared as the index of validity and accuracy for different modeling systems. In this basis it was realized that the semi-empirical equations especially Modified MST can accurately support the theoretical studies on phase equilibrium behavior of quinine–SCCO_2 media. Among the cubic equations of state DPGT within two-parametric vd W mixing rules provided the best data fitting and PR within one-parametric vd W mixing rules demonstrated the highest deviation respecting to the experimental data. Overall, in each individual modeling system the best fitting was observed on the data points attained at 318 K, which could be perhaps due to the moderate thermodynamic state of supercritical phase. 展开更多
关键词 Supercritical fluid Solubility Semi-empirical model Iso-fugacity quinine
下载PDF
New Method for Injectable Quinine Quality Assurance Control Using a Multi-Spectral Microscope
10
作者 A. Sow I. Traore +1 位作者 T. Diallo A. BA 《Optics and Photonics Journal》 2018年第3期66-74,共9页
Africa is the world region that is most affected by malaria. Among the therapies used, injectable quinine is considered to be one of the effective antimalarial drug, however non-quality assured antimalarials clearly h... Africa is the world region that is most affected by malaria. Among the therapies used, injectable quinine is considered to be one of the effective antimalarial drug, however non-quality assured antimalarials clearly have a strong market penetration across Africa. To overcome this problem, it becomes more and more necessary to set up quantitative and qualitative analysis system for antimalarial quality control. The objective of the present investigation is an attempt to use customized multispectral microscope equipped with UV-Visible lasers for injectable quinine quality assurance control routinely. For that, we have established the calibration curve of quinine solution concentration as a function of area under light intensity histogram crossing the solution. From this calibration curve, we can check the conformity of any injectable quinine according to the pharmacopoeia involved. The proposed technique is a promising alternative for drug quality control routinely. 展开更多
关键词 INJECTABLE quinine Area Under Curve MULTISPECTRAL MICROSCOPE ABSORBANCE
下载PDF
Quinine induced thrombotic microangiopathy and thrombocytopenia: A teaching hospital’s perspective
11
作者 Aaron J. Franke William Paul Skelton IV 《Advances in Generial Practice of Medicine》 2019年第1期9-12,共4页
Although quinine is an infrequently prescribed drug, with malaria treatment being its only FDA-approved indication, unwitting exposure via beverages (e.g., tonic water), over the counter herbal remedies and illegal re... Although quinine is an infrequently prescribed drug, with malaria treatment being its only FDA-approved indication, unwitting exposure via beverages (e.g., tonic water), over the counter herbal remedies and illegal recreation drugs still occur. We present a unique case of a female patient who denied any known prior history of quinine exposure, who after being prescribed quinine tablets for restless leg syndrome, developed an immune-related thrombotic microangiopathy with thrombocytopenia and subsequent multi-organ failure. It was later elucidated that her only known potential source of prior quinine exposure was a remote history of crackcocaine use. The patient survived this rare and severe inflammatory response with recovery of renal function and was able to discontinue dialysis. 展开更多
关键词 quinine TMA DRUG reaction DITMA THROMBOCYTOPENIA
下载PDF
Interactions of Aurein with Model Membranes and Antimalarials
12
作者 Anaif M. Alhewaitey Nsoki Phambu Naif M. Alhawiti 《American Journal of Analytical Chemistry》 CAS 2024年第2期72-98,共27页
Aurein is a cationic antimicrobial peptide, rich in phenylalanine residues. Although the peptide has been extensively studied, its mechanism of action is not fully understood and has not been established. This project... Aurein is a cationic antimicrobial peptide, rich in phenylalanine residues. Although the peptide has been extensively studied, its mechanism of action is not fully understood and has not been established. This project is focused on studying the interactions of aurein with model biological membranes and antimalarials using Fourier Transform Infrared (FTIR), fluorescence, dynamic light scattering (DLS), atomic force microscopy (AFM), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC) techniques. FTIR data revealed conformational changes to the secondary structure of the peptide in the presence of the model membranes. The strongest interactions of aurein were found with DOPC and lipid raft systems. Fluorescence data revealed some differences in the mechanism of interaction between aurein and lipid rafts. Topographical analysis was performed using atomic force microscopy (AFM). AFM images of the peptide with its lipid rafts showed a change in surface roughness suggesting a different mechanism of interaction. DLS data in agreement with FTIR confirmed that aurein interacts differently with the lipid rafts. The results gathered from this study provided new insights on the interaction of aurein. On the other hand, drug-drug interaction issues continue to present a major dilemma for the clinician caring for complex patients such as those infected with infectious disease. This study has examined the interaction of aurein with quinine, primaquine, and chloroquine. Significant interactions between aurein and antimalarials occured at a higher concentration of antimalarials. Interactions between aurein and anti-malarials reveal a strong interaction between aurein and primaquine. Interactions between aurein and quinine or chloroquine were found to be weak and negligible. FTIR, TGA, and DSC may be used in a complementary way to gain insights into the possible drug-drug interactions involving aurein. These studies are needed to initiate in vivo controlled interaction studies between antibiotics and antimalarials. 展开更多
关键词 Aurein Fluorescence DPPC SPM cholesterol DPPC-SPM-CHOL quinine ANTIMALARIALS
下载PDF
Efficacy and mechanism of a compound epirubicin plus quinine injection for the treatment of drug--resistant breast cancer
13
作者 刘磊 居瑞军 +4 位作者 谢红军 曾凡 张诚翔 赵炜煜 吕万良 《Journal of Chinese Pharmaceutical Sciences》 CAS CSCD 2015年第9期563-571,共9页
A single drug chemotherapy fails to eliminate residual cancer cells due to the existence of the multidrug resistance (MDR). In the present study, we aimed to develop a compound epirubicin plus quinine injection, to ... A single drug chemotherapy fails to eliminate residual cancer cells due to the existence of the multidrug resistance (MDR). In the present study, we aimed to develop a compound epirubicin plus quinine injection, to characterize the efficacy in treatment of the drug-resistant breast cancer, and to reveal the involved mechanisms. The HPLC-UV methods were developed for quantifications, and the evaluations were performed on the drug-resistant human breast cancer MCF-7/adr cells using a high content screening system. Results demonstrated that the compound epirubicin plus quinine injection was able to effectively block the drug efflux, exhibiting an evidently overall efficacy in treatment of the resistant breast cancer cells by direct killing effect and by apoptosis-inducing effect. In the formulation, quinine played multiple roles in blocking drug efflux and in inducing the apoptosis of the resistant breast cancer cells. The apoptosis signaling pathways were associated with a cascade of reactions by activating Caspase family and by inhibiting Bcl-2 family. In conclusion, the present study preliminarily revealed the efficacy and mechanism of the compound epirubicin plus quinine formulation in treatment of the drug-resistant breast cancer, and offered a potential strategy to overcome drug resistance in cancer treatments. 展开更多
关键词 Compound epirubicin plus quinine injection Blocking drug effiux Apoptosis Resistant breast cancer EFFICACY
原文传递
A fully bio-sourced adsorbent of heavy metals in water fabricated by immobilization of quinine on cellulose paper 被引量:1
14
作者 Ehu C.Aka Medy C.Nongbe +3 位作者 Tchirioua Ekou Lynda Ekou Vincent Coeffard Francois-Xavier Felpin 《Journal of Environmental Sciences》 SCIE EI CAS CSCD 2019年第10期174-183,共10页
The fabrication of a fully bio-sourced adsorbent of Cd(Ⅱ)by covalent immobilization of quinine on cellulose paper is described.The double bond of commercially available quinine was converted to a terminal alkyne func... The fabrication of a fully bio-sourced adsorbent of Cd(Ⅱ)by covalent immobilization of quinine on cellulose paper is described.The double bond of commercially available quinine was converted to a terminal alkyne function which was reacted with cellulose paper,chemically modified with azide functions,through a 1,3-dipolar cycloaddition,leading to Cell-Quin.The adsorption efficiency of Cell-Quin was investigated to determine the optimal pH,contact time and dose of adsorbent,ultimately leading to high levels of removal.The mechanism of adsorption of Cell-Quin was deeply rationalized through kinetic experiments and isotherm modeling.We also showed that Cell-Quin could adsorb other heavy metals such as Cu(Ⅱ),Pb(Ⅱ),Ni(Ⅱ)and Zn(Ⅱ). 展开更多
关键词 Cellulose paper quinine Heavy metal removal ADSORBENT
原文传递
TRANSFER MECHANISM OF QUININE DRUG ACROSS THE OIL/WATER (O/W) INTERFACE
15
作者 肖俊 聂利华 姚守拙 《Science China Chemistry》 SCIE EI CAS 1991年第1期42-53,共12页
The transfer phenomena of quinine drug at the aqueous 1,2- dichloroethane (DCE)interface have been studied by the current- scanning polarography. The relationships be-tween the wave height and pH of aqueous phase, con... The transfer phenomena of quinine drug at the aqueous 1,2- dichloroethane (DCE)interface have been studied by the current- scanning polarography. The relationships be-tween the wave height and pH of aqueous phase, concentration of quinine as well as therate of water drop are discussed. The effect of supporting electrolyte, buffer solution andthe nature of organic solvent on the polarographic wave is studied. The transfer char-acteristics of quinine in aqueous phase and in organic phase are compared, The mono- pro-tonated and diprotonated quinines can both transfer at the interface so as to produce twopolarographic waves. The transfer process of quinine at the interface is simultaneouslycontrolled by diffusion and reestablishment of the disturbed protonated equilibrium ofquinine. A further investigation is made by chronopotentiometry. On the basis of thetheoretical analysis, the formulae of the limiting current are derived and discussed. Thetheoretical results are in agreement with the experimental ones. The transfer mechanismof quinine is put forward. 展开更多
关键词 oil/water (O/W) INTERFACE ITIES kinetic current quinine DRUG current-scanning polarography
原文传递
Activating PPARy Increases NQO1 and γ-GCS Expression via Nrf2 in Thrombin-activated Microglia 被引量:4
16
作者 Hang HANG Li-kun WANG +2 位作者 Si-ying REN An-jun SONG Guo-feng WU 《Current Medical Science》 SCIE CAS 2020年第1期55-62,共8页
The present study aimed to explore the molecular mechanisms underlying the increase of nicotinamide adenine dinucleotide phosphate:quinine oxidoreductase 1(NQO1)and y-glutamylcysteine synthetase(γ-GCS)in brain tissue... The present study aimed to explore the molecular mechanisms underlying the increase of nicotinamide adenine dinucleotide phosphate:quinine oxidoreductase 1(NQO1)and y-glutamylcysteine synthetase(γ-GCS)in brain tissues after intracerebral hemorrhage(ICH).The microglial cells obtained from newborn rats were cultured and then randomly divided into the normal control group(NC group),model control group(MC group),rosiglitazone(RSG)intervention group(RSG group),retinoic-acid intervention group(RSG+RA group),and sulfbraphane group(RSG+SF group).The expression levels of NQO1,γ-GCS,and nuclear factor E2-related factor 2(Nrf2)were measured by real-time polymerase chain reaction(RT-PCR)and Western blotting,respectively.The results showed that the levels of NQO1,γ-GCS and Nrf2 were significantly increased in the MC group and the RSG group as compared with those in the NC group(P<0.01).They were found to be markedly decreased in the RSG+RA group and increased in the RSG+SF group when compared with those in the MC group or the RSG group(P<0.01).The RSG+SF group displayed the highest levels of NQO1,γ-GCS,and Nrf2 among the five groups.In conclusion,a medium dose of RSG increased the anti-oxidative ability of thrombinactivated microglia by increasing the expression of NQO1 and γ-GCS.The molecular mechanisms underlying the increase of NQO1 and γ-GCS in thrombin-activated microglia may be associated with the activation of Nrf2. 展开更多
关键词 ROSIGLITAZONE peroxisome proliferator-activated receptor y nuclear factor E2-related factor 2 nicotinamide adenine dinucleotide phosphate:quinine oxidoreductase γ-glutamylcysteine synthetase
下载PDF
Resolution pattern of jaundice among children presenting with severe malaria in rural South-West Nigeria 被引量:1
17
作者 Osonuga OA Osonuga A +1 位作者 Osonuga AA Osonuga IO 《Asian Pacific Journal of Tropical Biomedicine》 SCIE CAS 2012年第7期551-553,共3页
Objective:To compare the pattern of jaundice resolution among children with severe malaria treated with quinine and artemether.Methods:Thirty two children who fulfilled the inclusion criteria were recruited for the st... Objective:To compare the pattern of jaundice resolution among children with severe malaria treated with quinine and artemether.Methods:Thirty two children who fulfilled the inclusion criteria were recruited for the study from two hospitals with intensive care facilities.They were divided into two groups:'Q' and 'A',receiving quinine and artemether.respectively.Jaundice was assessed by clinical examination.Results:Sixteen out of 32 children recruited(representing50%) presented with jaundice on the dav of recruitment.The mean age was(7.00±2.56) years.On day 3,tour patients in 'A' and six patients in 'O' had jaundice.By day 7.no child had jaundice.Conclusion:The study has shown that hoth drugs resolve jaundice although artemether relatively resolves it faster by the third day. 展开更多
关键词 JAUNDICE quinine Artemether Severe malaria South-west NIGERIA
下载PDF
Application of Total Error Strategy in Validation of Affordable and Accessible UV-Visible Spectrophotometric Methods for Quality Control of Poor Medicines 被引量:1
18
作者 Jérémie Kindenge Mbinze Jean Nsangu Mpasi +8 位作者 Elza Maghe Sébastien Kobo Rodrigue Mwanda Guy Mulumba Jacquie Bolavie Bolande Trésor Menanzambi Bayebila Maguy Borive Amani Philippe Hubert Roland Djang’eing’a Marini 《American Journal of Analytical Chemistry》 2015年第2期106-117,共12页
In the framework of fighting against the poor quality medicines sold in developing countries using classical analytical methods easily accessible in those countries, four UV-Visible spectrophotometric methods for one ... In the framework of fighting against the poor quality medicines sold in developing countries using classical analytical methods easily accessible in those countries, four UV-Visible spectrophotometric methods for one antimalarial (quinine) and two antibiotics (amoxicillin and metronidazole) have been developed and validated according to the total error strategy using the accuracy profiles as a decision tool. The dosing range was 2 - 10 μg/mL (for quinine sulfate in tablet), 4 - 12 μg/mL (for quinine bichlorhydrate in oral drop-metronidazole benzaote in oral suspension) and 15 - 35 μg/mL (for amoxicillin trihydrate in capsule). The validated methods were then applied in determining the content of some analogous medicines sold in the Democratic Republic of Congo. Thus, the proposed UV-Visible spectrophotometric methods are simple and suitable to quantify quinine, amoxicillin and metronidazole in different pharmaceutical forms. 展开更多
关键词 POOR Quality MEDICINES UV-VISIBLE Spectrophotometric Methods quinine Amoxicillin METRONIDAZOLE VALIDATION Total Error Accuracy Profiles
下载PDF
ACUPUNCTURE TREATING 32 CASES OF MUSCULUS QUADRICEPS FEMORIS INJURY CAUSED BY QUINIMAX
19
作者 Ran Jinli Dept.of Acupuncture & Moxibustion,Beijing No.6 Hospital,100007,China 《World Journal of Acupuncture-Moxibustion》 1993年第4期13-14,23,共3页
Quinimax injection causes side effect characterized by pain and atrophy in mus-culus quadriceps femoris.Pain predominates in acute stage and corresponds to the Bi Syndrome,whileatrophy is seen in chronic stage,and ref... Quinimax injection causes side effect characterized by pain and atrophy in mus-culus quadriceps femoris.Pain predominates in acute stage and corresponds to the Bi Syndrome,whileatrophy is seen in chronic stage,and refers to the Wei Syndrome.The pain should be treated by acti-vating Qi and blood circulation.The atrophy should be treated on the principle of tonifying blood andnourishing tendons.The points of the stomach moridian are mostly selected for the treatment purposebecause they are abundant in Qi and blood.My try is successful.The cured rate is 61.76% and all 34diseased lower extremities are improved. 展开更多
关键词 MUSCULAR ATROPHY quinine injection ACUPUNCTURE therapy
下载PDF
The Epidemiological, Clinical, Paraclinical and Prognostic Aspects of Severe Malaria at the Regional Hospital of Thies
20
作者 Agbogbenkou Tévi Déla-dem Lawson Madoky Magatte Diop +5 位作者 Viviane Marie Pierre Cisse Stéphanie Akanni Adama Berthe Papa Souleymane Toure Bernard Marcel Diop Mamadou Mourtalla Ka 《Advances in Infectious Diseases》 2018年第3期162-171,共10页
Introduction: Malaria, the first parasitical endemic disease in the world, is a serious disease with 407,000 deaths in Africa in 2016. It is the main cause of morbidity and mortality in Senegal [1] [2]. Methods: Our r... Introduction: Malaria, the first parasitical endemic disease in the world, is a serious disease with 407,000 deaths in Africa in 2016. It is the main cause of morbidity and mortality in Senegal [1] [2]. Methods: Our retrospective study carried out from 1st January 2010 to 31 December 2013, at the department of internal medicine in the regional hospital of Thies was aimed at studying the epidemiological, clinical, paraclinical and prognostic profile of severe malaria in the autochthonous adults with 15 years and more. Results: Over this 3-year period, 57 patients were hospitalized in 1275 patients due to severe malaria that is to say a hospital prevalence of 4.47%. The average age was 64.21. A clear male predominance has been observed, around 61% (34/57) against 39% (23/57) with a sex ratio of 1.6. The highest malarial infestation rate was found at the end of the rainy season and at the beginning of the dry season (September to November). The clinical picture which predominates is the neurological affection which represented 33.3% of the cases. The different aspects of this neurological affection were of coma type, convulsion and prostration in 87%;21.7% and 8.6% respectively. The cerebral malaria was associated or not with other symptoms of severity that are anemia in 41.6%;icterus was represented in 21% of the cases, cardio-vascular collapse in 15.8% and hypoglycemia in 5.5% of the cases. The complications were observed during the hospitalization in 73.6% of the cases with the type of bacterial pneumonia (47.6%) and urinary infections (26.2%). The curative treatment was based on quinine salts through intravenous track in 100% of the case with a shift to the Artemisinin combination therapy (ACT) associated with intense care measures. In our study the whole lethality is 17%. Conclusion: The results of our study shows that the severe forms of malaria are still affecting our tropical endemic area, in spite of the prevention efforts made to fight against this plague. This research illustrates the difficulties to provide optimum medical care when combining antimalarial treatment and resuscitative measures in the decentralized reception facilities. 展开更多
关键词 MALARIA SEVERE MALARIA quinine ACT
下载PDF
上一页 1 2 下一页 到第
使用帮助 返回顶部