We evaluate an adaptive optimisation methodology,Bayesian optimisation(BO),for designing a minimum weight explosive reactive armour(ERA)for protection against a surrogate medium calibre kinetic energy(KE)long rod proj...We evaluate an adaptive optimisation methodology,Bayesian optimisation(BO),for designing a minimum weight explosive reactive armour(ERA)for protection against a surrogate medium calibre kinetic energy(KE)long rod projectile and surrogate shaped charge(SC)warhead.We perform the optimisation using a conventional BO methodology and compare it with a conventional trial-and-error approach from a human expert.A third approach,utilising a novel human-machine teaming framework for BO is also evaluated.Data for the optimisation is generated using numerical simulations that are demonstrated to provide reasonable qualitative agreement with reference experiments.The human-machine teaming methodology is shown to identify the optimum ERA design in the fewest number of evaluations,outperforming both the stand-alone human and stand-alone BO methodologies.From a design space of almost 1800 configurations the human-machine teaming approach identifies the minimum weight ERA design in 10 samples.展开更多
Explosive reactive armor(ERA)is currently being actively developed as a protective system for mobile devices against ballistic threats such as kinetic energy penetrators and shaped-charge jets.Considering mobility,the...Explosive reactive armor(ERA)is currently being actively developed as a protective system for mobile devices against ballistic threats such as kinetic energy penetrators and shaped-charge jets.Considering mobility,the aim is to design a protection system with a minimal amount of required mass.The efficiency of an ERA is sensitive to the impact position and the timing of the detonation.Therefore,different designs have to be tested for several impact scenarios to identify the best design.Since analytical models are not predicting the behavior of the ERA accurately enough and experiments,as well as numerical simulations,are too time-consuming,a data-driven model to estimate the displacements and deformation of plates of an ERA system is proposed here.The ground truth for the artificial neural network(ANN)is numerical simulation results that are validated with experiments.The ANN approximates the plate positions for different materials,plate sizes,and detonation point positions with sufficient accuracy in real-time.In a future investigation,the results from the model can be used to estimate the interaction of the ERA with a given threat.Then,a measure for the effectiveness of an ERA can be calculated.Finally,an optimal ERA can be designed and analyzed for any possible impact scenario in negligible time.展开更多
The experimental research on protection capability of the flying-whip multifunctional explosive reactive armor (ERA) was performed, in which the comparison experiment was made on the damage effect of the flying-whip&#...The experimental research on protection capability of the flying-whip multifunctional explosive reactive armor (ERA) was performed, in which the comparison experiment was made on the damage effect of the flying-whip's geometrical figuration, material property and driven velocity on the long-rod armor-piercing-projectile. The moving velocity of the flying-whip driven by different explosives and the pressure attenuation law of shock wave travelling in the back plate were measured respectively with the electric probe method and the manganin piezoresistive gauge technique. The following conclusions based on a great quantity of experimental data were drawn: compared with the sandwich ERA the flying-whip multifunctional ERA has very good protection function against the long-rod armor-piercing-projectile, the shaped charge warhead and the anti-armor tandem warhead. In addition, the composite plate made of the armor-steel and rubber plate can lessen the vibration and shock of the main armor caused by the explosion of the charge..展开更多
There are two interaction mechanisms between shaped charge jet and thin flying plate driven by explosion, that is, the intermittent and continuous disturbance. Determination of the transition criteria for the intermit...There are two interaction mechanisms between shaped charge jet and thin flying plate driven by explosion, that is, the intermittent and continuous disturbance. Determination of the transition criteria for the intermittent and continuous disturbance is of importance for the penetration calculation of the escaping jet and the design of ERA(explosive reactive armour). In this paper a new criteria was presented based on the analysis of interaction process, and the effects of NATO angle and thickness of flying plate on the disturbance frequency were discussed. It is shown that the critical shaped charge jet velocity increases with the plate thickness and NATO angle, especially increases drastically between 45° and 60°.展开更多
Stimuli-responsive delivery systems hold promise in cancer treatments.However,their application potential has been limited due to undesirable drug leaking during blood circulation and inefficient therapeutic efficacy ...Stimuli-responsive delivery systems hold promise in cancer treatments.However,their application potential has been limited due to undesirable drug leaking during blood circulation and inefficient therapeutic efficacy in tumors,resulting in undesirable therapeutic outcomes.Herein,we have developed a novel redox-sensitive pegylated phospholipid,termed as DOPE-SS-PEG,which can form a glutathione(GSH)-triggered precision explosive system(GPS)for simultaneously improving circulation stability,tumor specificity,and chemosensitivity,leading to explosive anticancer effects.GPS is constructed of liposomal doxorubicin(DOX)functionalized with DOPE-SS-PEG and MnO_(2) nanoparticles,which can protect liposome structure in the presence of serum GSH(20μM),whereas converts to cationic liposome in response to intracellular GSH(10 mM),thereby enhancing circulation stability,tumor specificity,endosomal escape,and cytoplasmic delivery.Importantly,GPS can not only generate oxygen to relieve hypoxia and consequently enhance chemosensitivity,but quench GSH antioxidability to elevate the accruement of intracellular reactive oxygen species(ROS),leading to an explosion of oxidative stress induced cell injury.Particularly,in vivo studies show that GPS selectively accumulates in tumor tissues,effectively inhibits tumor growth,exhibits minimal systemic adverse effects,and consequently prolongs the survival time of tumor-bearing mice.Therefore,GPS is a unique stimuli-responsive treatment with programmed and on-demand drug delivery,as well as explosive therapeutic efficacy,and provides an intelligent anticancer treatment.展开更多
文摘We evaluate an adaptive optimisation methodology,Bayesian optimisation(BO),for designing a minimum weight explosive reactive armour(ERA)for protection against a surrogate medium calibre kinetic energy(KE)long rod projectile and surrogate shaped charge(SC)warhead.We perform the optimisation using a conventional BO methodology and compare it with a conventional trial-and-error approach from a human expert.A third approach,utilising a novel human-machine teaming framework for BO is also evaluated.Data for the optimisation is generated using numerical simulations that are demonstrated to provide reasonable qualitative agreement with reference experiments.The human-machine teaming methodology is shown to identify the optimum ERA design in the fewest number of evaluations,outperforming both the stand-alone human and stand-alone BO methodologies.From a design space of almost 1800 configurations the human-machine teaming approach identifies the minimum weight ERA design in 10 samples.
文摘Explosive reactive armor(ERA)is currently being actively developed as a protective system for mobile devices against ballistic threats such as kinetic energy penetrators and shaped-charge jets.Considering mobility,the aim is to design a protection system with a minimal amount of required mass.The efficiency of an ERA is sensitive to the impact position and the timing of the detonation.Therefore,different designs have to be tested for several impact scenarios to identify the best design.Since analytical models are not predicting the behavior of the ERA accurately enough and experiments,as well as numerical simulations,are too time-consuming,a data-driven model to estimate the displacements and deformation of plates of an ERA system is proposed here.The ground truth for the artificial neural network(ANN)is numerical simulation results that are validated with experiments.The ANN approximates the plate positions for different materials,plate sizes,and detonation point positions with sufficient accuracy in real-time.In a future investigation,the results from the model can be used to estimate the interaction of the ERA with a given threat.Then,a measure for the effectiveness of an ERA can be calculated.Finally,an optimal ERA can be designed and analyzed for any possible impact scenario in negligible time.
文摘The experimental research on protection capability of the flying-whip multifunctional explosive reactive armor (ERA) was performed, in which the comparison experiment was made on the damage effect of the flying-whip's geometrical figuration, material property and driven velocity on the long-rod armor-piercing-projectile. The moving velocity of the flying-whip driven by different explosives and the pressure attenuation law of shock wave travelling in the back plate were measured respectively with the electric probe method and the manganin piezoresistive gauge technique. The following conclusions based on a great quantity of experimental data were drawn: compared with the sandwich ERA the flying-whip multifunctional ERA has very good protection function against the long-rod armor-piercing-projectile, the shaped charge warhead and the anti-armor tandem warhead. In addition, the composite plate made of the armor-steel and rubber plate can lessen the vibration and shock of the main armor caused by the explosion of the charge..
文摘There are two interaction mechanisms between shaped charge jet and thin flying plate driven by explosion, that is, the intermittent and continuous disturbance. Determination of the transition criteria for the intermittent and continuous disturbance is of importance for the penetration calculation of the escaping jet and the design of ERA(explosive reactive armour). In this paper a new criteria was presented based on the analysis of interaction process, and the effects of NATO angle and thickness of flying plate on the disturbance frequency were discussed. It is shown that the critical shaped charge jet velocity increases with the plate thickness and NATO angle, especially increases drastically between 45° and 60°.
基金This work were supported by the National Key Research and Development Program of China(No.2019YFA0802800)the National Key Research and Development Program of China(No.2018YFB1105400)+3 种基金the National Natural Science Foundation of China(No.21472090)the Natural Science Foundation of Jiangsu Province(No.BK20180334)the Fundamental Research Funds for Central Universities Nanjing University,the Scientific Research Foundation of Graduate School of Nanjing University(No.2018CL12)The Key Research and Development Program of Jiangsu Provincial Department of Science and Technology of China(No.BE2019002).
文摘Stimuli-responsive delivery systems hold promise in cancer treatments.However,their application potential has been limited due to undesirable drug leaking during blood circulation and inefficient therapeutic efficacy in tumors,resulting in undesirable therapeutic outcomes.Herein,we have developed a novel redox-sensitive pegylated phospholipid,termed as DOPE-SS-PEG,which can form a glutathione(GSH)-triggered precision explosive system(GPS)for simultaneously improving circulation stability,tumor specificity,and chemosensitivity,leading to explosive anticancer effects.GPS is constructed of liposomal doxorubicin(DOX)functionalized with DOPE-SS-PEG and MnO_(2) nanoparticles,which can protect liposome structure in the presence of serum GSH(20μM),whereas converts to cationic liposome in response to intracellular GSH(10 mM),thereby enhancing circulation stability,tumor specificity,endosomal escape,and cytoplasmic delivery.Importantly,GPS can not only generate oxygen to relieve hypoxia and consequently enhance chemosensitivity,but quench GSH antioxidability to elevate the accruement of intracellular reactive oxygen species(ROS),leading to an explosion of oxidative stress induced cell injury.Particularly,in vivo studies show that GPS selectively accumulates in tumor tissues,effectively inhibits tumor growth,exhibits minimal systemic adverse effects,and consequently prolongs the survival time of tumor-bearing mice.Therefore,GPS is a unique stimuli-responsive treatment with programmed and on-demand drug delivery,as well as explosive therapeutic efficacy,and provides an intelligent anticancer treatment.
