Generalized exponential distribution is a class of important distribution in lifedata analysis,especially in some skewed lifedata.The Parameter estimation problem for generalized exponential distribution model with gr...Generalized exponential distribution is a class of important distribution in lifedata analysis,especially in some skewed lifedata.The Parameter estimation problem for generalized exponential distribution model with grouped and right-censored data is considered.The maximum likelihood estimators are obtained using the EM algorithm.Some simulations are carried out to illustrate that the proposed algorithm is effective for the model.Finally,a set of medicine data is analyzed by generalized exponential distribution.展开更多
This paper considers the monotonic transformation model with an unspecified transformation function and an unknown error function, and gives its monotone rank estimation with length-biased and rightcensored data. The ...This paper considers the monotonic transformation model with an unspecified transformation function and an unknown error function, and gives its monotone rank estimation with length-biased and rightcensored data. The estimator is shown to be√n-consistent and asymptotically normal. Numerical simulation studies reveal good finite sample performance and the estimator is illustrated with the Oscar data set. The variance can be estimated by a resampling method via perturbing the U-statistics objective function repeatedly.展开更多
Length-biased data arise in many important fields, including epidemiological cohort studies, cancer screening trials and labor economics. Analysis of such data has attracted much attention in the literature. In this p...Length-biased data arise in many important fields, including epidemiological cohort studies, cancer screening trials and labor economics. Analysis of such data has attracted much attention in the literature. In this paper we propose a quantile regression approach for analyzing right-censored and length-biased data. We derive an inverse probability weighted estimating equation corresponding to the quantile regression to correct the bias due to length-bias sampling and informative censoring. This method can easily handle informative censoring induced by length-biased sampling. This is an appealing feature of our proposed method since it is generally difficult to obtain unbiased estimates of risk factors in the presence of length-bias and informative censoring. We establish the consistency and asymptotic distribution of the proposed estimator using empirical process techniques. A resampling method is adopted to estimate the variance of the estimator. We conduct simulation studies to evaluate its finite sample performance and use a real data set to illustrate the application of the proposed method.展开更多
Prevalent cohort studies frequently involve length-biased and right-censored data, a fact that has drawn considerable attention in survival analysis. In this article, we consider survival data arising from lengthbiase...Prevalent cohort studies frequently involve length-biased and right-censored data, a fact that has drawn considerable attention in survival analysis. In this article, we consider survival data arising from lengthbiased sampling, and propose a new semiparametric-model-based approach to estimate quantile differences of failure time. We establish the asymptotic properties of our new estimators theoretically under mild technical conditions, and propose a resampling method for estimating their asymptotic variance. We then conduct simulations to evaluate the empirical performance and efficiency of the proposed estimators, and demonstrate their application by a real data analysis.展开更多
This paper introduces a semi-parametric model with right-censored data and a monotone constraint on the nonparametrie part. The authors study the local linear estimators of the parametric coefficients and apply B-spli...This paper introduces a semi-parametric model with right-censored data and a monotone constraint on the nonparametrie part. The authors study the local linear estimators of the parametric coefficients and apply B-spline method to approximate the nonparametric part based on grouped data. The authors obtain the rates of convergence for parametric and nonparametric estimators. Moreover, the authors also prove that the nonparametric estimator is consistent at the boundary. At last, the authors investigate the finite sample performance of the estimation.展开更多
We analyze left-truncated and right-censored data using Cox proportional hazard models with long-term survivors. The estimators of covariate coefficients and the long-term survivor proportion are obtained by the parti...We analyze left-truncated and right-censored data using Cox proportional hazard models with long-term survivors. The estimators of covariate coefficients and the long-term survivor proportion are obtained by the partial likelihood method, and their asymptotic properties are also established. Simulation studies demonstrate the performance of the proposed estimators, and an application to a real dataset is provided.展开更多
We propose a new nonparametric method for assessing non-inferiority of an experimental therapy compared to a standard of care. The ratio μE/μR of true median survival times is the parameter of interest. This is of c...We propose a new nonparametric method for assessing non-inferiority of an experimental therapy compared to a standard of care. The ratio μE/μR of true median survival times is the parameter of interest. This is of considerable interest in clinical trials of generic drugs. We think of the ratio mE/mR of the sample medians as a point estimate of the ratioμE/μR. We use the Fieller-Hinkley distribution of the ratio of two normally distributed random variables to derive an unbiased level-α test of inferiority null hypothesis, which is stated in terms of the ratio μE/μR and a pre-specified fixed non-inferiority margin δ. We also explain how to assess equivalence and non-inferiority using bootstrap equivalent confidence intervals on the ratioμE/μR. The proposed new test does not require the censoring distributions for the two arms to be equal and it does not require the hazard rates to be proportional. If the proportional hazards assumption holds good, the proposed new test is more attractive. We also discuss sample size determination. We claim that our test procedure is simple and attains adequate power for moderate sample sizes. We extend the proposed test procedure to stratified analysis. We propose a “two one-sided tests” approach for assessing equivalence.展开更多
This paper studies the asymptotic normality of the Nelson-Aalen and the Kaplan-Meier estimators in a competing risks context in presence of independent right-censorship. To prove our results, we use Robelledo’s theor...This paper studies the asymptotic normality of the Nelson-Aalen and the Kaplan-Meier estimators in a competing risks context in presence of independent right-censorship. To prove our results, we use Robelledo’s theorem which makes it possible to apply the central limit theorem to certain types of particular martingales. From the results obtained, confidence bounds for the hazard and the survival functions are provided.展开更多
Yu et al. (2012) considered a certain dependent right censorship model. We show that this model is equivalent to the independent right censorship model, extending a result with continuity restriction in Williams and L...Yu et al. (2012) considered a certain dependent right censorship model. We show that this model is equivalent to the independent right censorship model, extending a result with continuity restriction in Williams and Lagakos (1977). Then the asymptotic normality of the product limit estimator under the dependent right censorship model follows from the existing results in the literature under the independent right censorship model, and thus partially solves an open problem in the literature.展开更多
Exclusive hypothesis testing is a new and special class of hypothesis testing.This kind of testing can be applied in survival analysis to understand the association between genomics information and clinical informatio...Exclusive hypothesis testing is a new and special class of hypothesis testing.This kind of testing can be applied in survival analysis to understand the association between genomics information and clinical information about the survival time.Besides,it is well known that Cox's proportional hazards model is the most commonly used model for regression analysis of failure time.In this paper,the authors consider doing the exclusive hypothesis testing for Cox's proportional hazards model with right-censored data.The authors propose the comprehensive test statistics to make decision,and show that the corresponding decision rule can control the asymptotic TypeⅠerrors and have good powers in theory.The numerical studies indicate that the proposed approach works well for practical situations and it is applied to a set of real data arising from Rotterdam Breast Cancer Data study that motivated this study.展开更多
The problem of hazard rate estimation under right-censored assumption has been investigated extensively.Integrated square error(ISE)of estimation is one of the most widely accepted measurements of the global performan...The problem of hazard rate estimation under right-censored assumption has been investigated extensively.Integrated square error(ISE)of estimation is one of the most widely accepted measurements of the global performance for nonparametric kernel estimation.But there are no results available for ISE of hazard rate estimation under right-censored model with censoring indicators missing at random(MAR)so far.This paper constructs an imputation estimator of the hazard rate function and establish asymptotic normality of the ISE for the kernel hazard rate estimator with censoring indicators MAR.At the same time,an asymptotic representation of the mean integrated square error(MISE)is also presented.The finite sample behavior of the estimator is investigated via one simple simulation.展开更多
文摘Generalized exponential distribution is a class of important distribution in lifedata analysis,especially in some skewed lifedata.The Parameter estimation problem for generalized exponential distribution model with grouped and right-censored data is considered.The maximum likelihood estimators are obtained using the EM algorithm.Some simulations are carried out to illustrate that the proposed algorithm is effective for the model.Finally,a set of medicine data is analyzed by generalized exponential distribution.
基金supported by Graduate Innovation Foundation of Shanghai University of Finance and Economics(Grant No.CXJJ2013-451)Cultivation Foundation of Excellent Doctor Degree Dissertation of Shanghai University of Finance and Economics(Grant No.YBPY201504)+4 种基金Program of Educational Department of Fujian Province(Grant Nos.JA14079 and JA12060)Natural Science Foundation of Fujian Province(Grant Nos.2014J01001 and 2012J01028)National Natural Science Foundation of China(Grant No.71271128)the State Key Program of National Natural Science Foundation of China(Grant No.71331006)National Center for Mathematics and Interdisciplinary Sciences,Key Laboratory of Random Complex Structures and Data Science,Chinese Academy of Sciences and Shanghai First-class Discipline A and Innovative Research Team of Shanghai University of Finance and Economics,Program for Changjiang Scholars Innovative Research Team of Ministry of Education(Grant No.IRT13077)
文摘This paper considers the monotonic transformation model with an unspecified transformation function and an unknown error function, and gives its monotone rank estimation with length-biased and rightcensored data. The estimator is shown to be√n-consistent and asymptotically normal. Numerical simulation studies reveal good finite sample performance and the estimator is illustrated with the Oscar data set. The variance can be estimated by a resampling method via perturbing the U-statistics objective function repeatedly.
基金National Natural Science Funds for Distinguished Young Scholar (No. 70825004)Creative Research Groups of China (No. 10721101)+1 种基金Shanghai University of Finance and Economics Project 211 Phase ⅢShanghai Leading Academic Discipline Project (No. B803)
文摘Length-biased data arise in many important fields, including epidemiological cohort studies, cancer screening trials and labor economics. Analysis of such data has attracted much attention in the literature. In this paper we propose a quantile regression approach for analyzing right-censored and length-biased data. We derive an inverse probability weighted estimating equation corresponding to the quantile regression to correct the bias due to length-bias sampling and informative censoring. This method can easily handle informative censoring induced by length-biased sampling. This is an appealing feature of our proposed method since it is generally difficult to obtain unbiased estimates of risk factors in the presence of length-bias and informative censoring. We establish the consistency and asymptotic distribution of the proposed estimator using empirical process techniques. A resampling method is adopted to estimate the variance of the estimator. We conduct simulation studies to evaluate its finite sample performance and use a real data set to illustrate the application of the proposed method.
基金supported by National Natural Science Foundation of China(Grant No.11401603)the Fundamental Research Funds for the Central Universities(Grant No.QL 18009)+2 种基金Discipline Foundation of Central University of Finance and Economics(Grant No.CUFESAM201811)supported by the State Key Program of National Natural Science Foundation of China(Grant No.71331006)the State Key Program in the Major Research Plan of National Natural Science Foundation of China(Grant No.91546202)
文摘Prevalent cohort studies frequently involve length-biased and right-censored data, a fact that has drawn considerable attention in survival analysis. In this article, we consider survival data arising from lengthbiased sampling, and propose a new semiparametric-model-based approach to estimate quantile differences of failure time. We establish the asymptotic properties of our new estimators theoretically under mild technical conditions, and propose a resampling method for estimating their asymptotic variance. We then conduct simulations to evaluate the empirical performance and efficiency of the proposed estimators, and demonstrate their application by a real data analysis.
基金supported by Fundamental Research Funds for the Central Universitiesthe Research Funds of Renmin University of China under Grant No.11XNK027
文摘This paper introduces a semi-parametric model with right-censored data and a monotone constraint on the nonparametrie part. The authors study the local linear estimators of the parametric coefficients and apply B-spline method to approximate the nonparametric part based on grouped data. The authors obtain the rates of convergence for parametric and nonparametric estimators. Moreover, the authors also prove that the nonparametric estimator is consistent at the boundary. At last, the authors investigate the finite sample performance of the estimation.
基金Natural Science Funds for Distinguished Young Scholar (No. 70825004)Creative Research Groups of China (No. 10721101)+2 种基金Shanghai University of Finance and Economics Project 211 Phase ⅢShanghai Leading Academic Discipline Project (No. B803)Zhou's work was supported by Graduate Creation Funds of Shanghai University of Finance and Economics(No. CXJJ-2011-436)
文摘We analyze left-truncated and right-censored data using Cox proportional hazard models with long-term survivors. The estimators of covariate coefficients and the long-term survivor proportion are obtained by the partial likelihood method, and their asymptotic properties are also established. Simulation studies demonstrate the performance of the proposed estimators, and an application to a real dataset is provided.
文摘We propose a new nonparametric method for assessing non-inferiority of an experimental therapy compared to a standard of care. The ratio μE/μR of true median survival times is the parameter of interest. This is of considerable interest in clinical trials of generic drugs. We think of the ratio mE/mR of the sample medians as a point estimate of the ratioμE/μR. We use the Fieller-Hinkley distribution of the ratio of two normally distributed random variables to derive an unbiased level-α test of inferiority null hypothesis, which is stated in terms of the ratio μE/μR and a pre-specified fixed non-inferiority margin δ. We also explain how to assess equivalence and non-inferiority using bootstrap equivalent confidence intervals on the ratioμE/μR. The proposed new test does not require the censoring distributions for the two arms to be equal and it does not require the hazard rates to be proportional. If the proportional hazards assumption holds good, the proposed new test is more attractive. We also discuss sample size determination. We claim that our test procedure is simple and attains adequate power for moderate sample sizes. We extend the proposed test procedure to stratified analysis. We propose a “two one-sided tests” approach for assessing equivalence.
文摘This paper studies the asymptotic normality of the Nelson-Aalen and the Kaplan-Meier estimators in a competing risks context in presence of independent right-censorship. To prove our results, we use Robelledo’s theorem which makes it possible to apply the central limit theorem to certain types of particular martingales. From the results obtained, confidence bounds for the hazard and the survival functions are provided.
文摘Yu et al. (2012) considered a certain dependent right censorship model. We show that this model is equivalent to the independent right censorship model, extending a result with continuity restriction in Williams and Lagakos (1977). Then the asymptotic normality of the product limit estimator under the dependent right censorship model follows from the existing results in the literature under the independent right censorship model, and thus partially solves an open problem in the literature.
基金supported by the National Natural Science Foundation of China under Grant Nos.11971064,12371262,and 12171374。
文摘Exclusive hypothesis testing is a new and special class of hypothesis testing.This kind of testing can be applied in survival analysis to understand the association between genomics information and clinical information about the survival time.Besides,it is well known that Cox's proportional hazards model is the most commonly used model for regression analysis of failure time.In this paper,the authors consider doing the exclusive hypothesis testing for Cox's proportional hazards model with right-censored data.The authors propose the comprehensive test statistics to make decision,and show that the corresponding decision rule can control the asymptotic TypeⅠerrors and have good powers in theory.The numerical studies indicate that the proposed approach works well for practical situations and it is applied to a set of real data arising from Rotterdam Breast Cancer Data study that motivated this study.
基金the China Postdoctoral Science Foundation under Grant No.2019M651422the National Natural Science Foundation of China under Grant Nos.71701127,11831008 and 11971171+3 种基金the National Social Science Foundation Key Program under Grant No.17ZDA091the 111 Project of China under Grant No.B14019the Natural Science Foundation of Shanghai under Grant Nos.17ZR1409000 and 20ZR1423000the Project of Humanities and Social Science Foundation of Ministry of Education under Grant No.20YJC910003。
文摘The problem of hazard rate estimation under right-censored assumption has been investigated extensively.Integrated square error(ISE)of estimation is one of the most widely accepted measurements of the global performance for nonparametric kernel estimation.But there are no results available for ISE of hazard rate estimation under right-censored model with censoring indicators missing at random(MAR)so far.This paper constructs an imputation estimator of the hazard rate function and establish asymptotic normality of the ISE for the kernel hazard rate estimator with censoring indicators MAR.At the same time,an asymptotic representation of the mean integrated square error(MISE)is also presented.The finite sample behavior of the estimator is investigated via one simple simulation.
