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Characteristics and dynamics of the Ganqiuchi rock avalanche triggered by a paleo-earthquake in the Northern Qinling Mountains
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作者 ZHOU Ze-Hua LYU Yan +4 位作者 SU Sheng-rui LIU Shi-jie ZHAO Hui LI Peng ZHOU Yang 《Journal of Mountain Science》 SCIE CSCD 2020年第5期1143-1160,共18页
Analyzing large prehistoric rock avalanches provides significant data for evaluating the disaster posed by these relatively infrequent but destructive geological events. This paper attempts to study the characteristic... Analyzing large prehistoric rock avalanches provides significant data for evaluating the disaster posed by these relatively infrequent but destructive geological events. This paper attempts to study the characteristics and dynamics of the Ganqiuchi granitic rock avalanche, in the middle of the northern margin of Qinling Mountains, 30 km to the south of Xi’an, Shaanxi Province, China. In plane view, this rock avalanche is characterized by source area, accumulation area and dammed lake area. Based on previous studies, historical records and regional geological data, the major trigger of the Ganqiuchi rock avalanche is considered to be a strong paleo-earthquake with tremendous energy. The in situ deposit block size distributions of the intact rock mass and the debris deposits are presented and analyzed by using a simple model for estimating the number of fragmentation cycles that the blocks underwent. The results show that the primary controlling factor of the fragmentation process is the pre-existing fractures, and there is a relationship between the potential energy and the fragmentation energy: the latter is approximately 20% of the former. Based on the dynamic discrete element technique, the study proposes a four-stage model for the dynamic course of the Ganqiuchi rock avalanche:(1) failing;(2) highspeed sliding;(3) collision with obstacles;(4) decelerated sliding, which has implication for hazard assessment of the potential rock avalanches in China and other countries with similar geological setting. 展开更多
关键词 Ganqiuchi rock avalanche Deposit block size distribution FRAGMENTATION Discrete element method rock avalanche dynamics
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Landslide dynamic process and parameter sensitivity analysis by discrete element method: the case of Turnoff Creek rock avalanche
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作者 An Hui-cong Ouyang Chao-jun +1 位作者 Zhao Chuan Zhao Wei 《Journal of Mountain Science》 SCIE CSCD 2020年第7期1581-1595,共15页
The great diversity and complexity of geological hazards in terms of flowing materials,environment,triggering mechanisms and physical processes during the flow bring great difficulties to the numerical parameter selec... The great diversity and complexity of geological hazards in terms of flowing materials,environment,triggering mechanisms and physical processes during the flow bring great difficulties to the numerical parameter selection for the discrete element method.In order to identity the significance of individual parameters on the landslides dynamic process and provide valuable contribution to the runout analysis of similar landslide,the dynamic process and associated microscopic mechanism of the Turnoff Creek rock avalanche in Canada are simulated.The present numerical results are compared with the field survey data and the results of depth-integrated continuum method.The final deposit range matches well with the field survey data.It is illustrated that the discrete element method is robust and feasible to capture the dynamic characteristics of large rock avalanche over a complex terrain.Besides,a new method to assess the landslide hazard level based on the discrete element method is proposed.According to the parameter sensitivity analysis,it is demonstrated that the basal friction coefficient and bond strength are essential to the final deposit while rolling coefficient and restitution coefficient have little effects on it. 展开更多
关键词 Discrete element method Contact model Numerical modeling rock avalanche Geological hazard assessment Parameter analysis
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Numerical investigation of effects of “baffles-deceleration strip” hybrid system on rock avalanches 被引量:1
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作者 BI Yu-zhang HE Si-ming +4 位作者 DU Yan-jun SHAN Jie YAN Shuai-xing WANG Dong-po SUN Xin-po 《Journal of Mountain Science》 SCIE CSCD 2019年第2期414-427,共14页
Arrays of baffles are usually installed in front of protection site to attenuate the flow energy of rock avalanches in mountainous areas. Optimization design is crucial for efficiency promotion in hazard energy dissip... Arrays of baffles are usually installed in front of protection site to attenuate the flow energy of rock avalanches in mountainous areas. Optimization design is crucial for efficiency promotion in hazard energy dissipation engineering. In this study, a deceleration strip was added in the baffles protection system to optimize the traditional baffles system. The effects of the "baffles-deceleration strip" hybrid protection system was discussed in detail with the nails number and nails angle. This study presents details of numerical experiments using the discreteelement method(DEM). The effect of the optimization of hybrid protection system(nail angle and nail number) were investigated specifically, especially the impact force that avalanches exerted on structures. The results show that the maximum impact forces and kinetic energy of the rock avalanches decreases with the increase of the number and angle of the nail. Moreover, the distance between the toe and the bearing structure(L_m) is also a key factor. The shorter the distance L_m(30 m) is, the higher the maximum impact force are. The longer the distance L_m(70 m) is, the lower the maximum impact force are. Under the same size of the nails, increasing the numbers can enhance the dissipation ability of the hybrid protection system. Meanwhile, increasing itsangle can also enhance the dissipation ability. There are three key ways for nails attenuate rock avalanches:(i) block the fine particles directly;(ii) form the particles bridge between nails and baffles;(iii) dissipate the coarse particles energy directly. The effect of segregation in rock avalanches is crucial for the energy dissipation mechanism, which is a key factor to optimize the traditional baffle system. 展开更多
关键词 rock avalancheS Baffles Hybrid system Energy DISSIPATION Impact force
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Discrete Element Modeling of Tangjiagou Two-Branch Rock Avalanche Triggered by the 2013 Lushan MW6.6 Earthquake,China 被引量:1
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作者 CAO Yanbo XU Chong NAN Yalin 《Earthquake Research in China》 CSCD 2020年第1期81-95,共15页
Two branches of Tangjiagou rock avalanche were triggered by Lushan earthquake in Sichuan Province,China on April 20th,2013.The rock avalanche has transported about 1500000 m3 of sandstone from the source area.Based on... Two branches of Tangjiagou rock avalanche were triggered by Lushan earthquake in Sichuan Province,China on April 20th,2013.The rock avalanche has transported about 1500000 m3 of sandstone from the source area.Based on discrete element modeling,this study simulates the deformation,failure and movement process of the rock avalanche.Under seismic loading,the mechanism and process of deformation,failure,and runout of the two branches are similar.In detail,the stress concentration occur firstly on the top of the mountain ridge,and accordingly,the tensile deformation appears.With the increase of seismic loading,the strain concentration zone extends in the forward and backward directions along the slipping surface,forming a locking segment.As a result,the slipping surface penetrates and the slide mass begin to slide down with high speed.Finally,the avalanche accumulates in the downstream and forms a small barrier lake.Modeling shows that a number of rocks on the surface exhibit patterns of horizontal throwing and vertical jumping under strong ground shaking.We suggest that the movement of the rock avalanche is a complicated process with multiple stages,including formation of the two branches,high-speed sliding,transformation into debris flows,further movement and collision,accumulation,and the final steady state.Topographic amplification effects are also revealed based on acceleration and velocity of special monitoring points.The horizontal and vertical runout distances of the surface materials are much greater than those of the internal materials.Besides,the sliding duration is also longer than that of the internal rock mass. 展开更多
关键词 Tangjiagou two-branch rock avalanche Lushan EARTHQUAKE Deformation and MOVEMENT process Discrete element modeling
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Model tests for surge height of rock avalanche–debris flows based on momentum balance
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作者 Haixin Zhao Lingkan Yao 《Journal of Modern Transportation》 2019年第4期334-340,共7页
Rock avalanche–debris flows triggered by earthquakes commonly take place in mountainous areas.When entering a body of water,due to good fluidity they can move for some time instead of halting in water.In this study,w... Rock avalanche–debris flows triggered by earthquakes commonly take place in mountainous areas.When entering a body of water,due to good fluidity they can move for some time instead of halting in water.In this study,we proposed a method for calculating the surge height of rock avalanche–debris flows based on momentum balance and designed a series of model tests to validate this method.The experimental variables include the initial water depth,landslide velocity,and landslide volume.According to the experimental results,we analyzed the maximum wave height in sliding zone based on momentum balance.In addition,we investigated the surge height and proposed the calculation method in propagating zone and running up zone.In this way,we can find out the surge height in different areas when a rock avalanche–debris flow impacts into the water,which could provide a basis for analyzing the burst of barrier lakes. 展开更多
关键词 SURGE rock avalanche–debris flow MOMENTUM balance Barrier lake
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Protective effect of retaining wall on rock avalanche:A case study of Nayong rock avalanche in China
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作者 WANG Zhongfu SHI Fengge +3 位作者 HE Siming ZHANG Xusheng WANG Jingying LIU Enlong 《Journal of Mountain Science》 SCIE 2024年第4期1215-1230,共16页
Rock avalanches are generally difficult to prevent and control due to their high velocities and the extensive destruction they cause.However,barrier structures constructed along the path of a rock avalanche can partia... Rock avalanches are generally difficult to prevent and control due to their high velocities and the extensive destruction they cause.However,barrier structures constructed along the path of a rock avalanche can partially mitigate the magnitudes and consequences of such catastrophic events.We selected a rock avalanche in Nayong County,Guizhou Province,China as a case to study the effect of the location and height of a retaining wall on the dynamic characteristics of rock avalanche by using both actual terrain-based laboratory-model tests and coupled PFC3D-FLAC3D numerical simulations.Our findings demonstrate that a retaining wall can largely block a rock avalanche and its protective efficacy is significantly influenced by the integrity of the retaining wall.Coupled numerical simulation can serve as a powerful tool for analyzing the interaction between a rock avalanche and a retaining wall,facilitating precise observations of its deformation and destruction.The impact-curve characteristics of the retaining wall depend upon whether or not the rock avalanche-induced destruction is taken into account.The location of the retaining wall exerts a greater influence on the outcome compared to the height and materials of the retaining wall,while implementing a stepped retaining-wall pattern in accordance with the terrain demonstrates optimal efficacy in controlling rock avalanche. 展开更多
关键词 rock avalanche Laboratory model test Retaining wall PFC^(3D) FLAC^(3D) Impact force
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Crown-Like Baffle System against Rock Avalanches:Energy Dissipation Mechanism and Numerical Verification
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作者 Yu Huang Hao Shi Bei Zhang 《Journal of Earth Science》 SCIE CAS CSCD 2023年第2期304-315,共12页
In mountainous areas,rock avalanches swarm downslope leading to large impact forces on structures.Baffle systems are usually set up in torrent channels to dissipate the flow energy and reduce the destructive effects.I... In mountainous areas,rock avalanches swarm downslope leading to large impact forces on structures.Baffle systems are usually set up in torrent channels to dissipate the flow energy and reduce the destructive effects.In this paper,a crown-like baffle system is proposed to better dissipate the flow energy.The energy dissipation mechanism of this system was investigated based on DEM.The results reveal more than 90%of the kinetic energy of the granular flow was dissipated by particleparticle interaction.Two effects,the impedance effect and the deflection effect,were identified.The influence of these effects leads to the formation and growth of cushions behind the baffles,and these cushions enhance the particle-particle interaction.Two crown-like baffle systems were compared with a conventional baffle system based on the typical avalanche model.The results reveal the cumulative residual kinetic energy of the crown-like baffle system with square baffles decreased by 18.75%with the same concrete consumption as the conventional baffle system.For the crown-like baffle system with triangular baffles,the cumulative residual kinetic energy decreased by 6.22%with 83.94%of the concrete consumption of the conventional baffle system.Hence,the proposed baffle system is more cost-effective compared with the conventional baffle system. 展开更多
关键词 rock avalanches new baffle system energy dissipation discrete element method engineering geology
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桃叶珊瑚苷调节RhoA/ROCK信号通路对胶质母细胞瘤细胞活力和上皮间质转化的影响
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作者 李娟 石海平 李维民 《天津中医药》 CAS 2024年第3期386-392,共7页
[目的]研究桃叶珊瑚苷(AU)对胶质母细胞瘤(GBM)细胞活力和上皮间质转化(EMT)的影响,并对其作用机制进行探讨。[方法]将U87细胞随机分为对照组、AU低浓度组、AU中浓度组、AU高浓度组、Y-27632组、AU高浓度+Y-27632组。细胞计数器试剂盒(C... [目的]研究桃叶珊瑚苷(AU)对胶质母细胞瘤(GBM)细胞活力和上皮间质转化(EMT)的影响,并对其作用机制进行探讨。[方法]将U87细胞随机分为对照组、AU低浓度组、AU中浓度组、AU高浓度组、Y-27632组、AU高浓度+Y-27632组。细胞计数器试剂盒(CCK-8)法检测细胞活力,流式细胞术检测细胞凋亡,Transwell小室实验检测细胞迁移和侵袭,蛋白免疫印迹法(Western Blot)检测基质金属蛋白酶(MMP)2、MMP9、波形蛋白(Vimentin)、上皮钙黏蛋白(E-cadherin)、神经钙黏蛋白(N-cadherin)、Ras同源基因家族成员A(RhoA)、Rho相关卷曲螺旋蛋白激酶(ROCK)1、ROCK2表达。构建GBM裸鼠模型,随机分为裸鼠对照组、AU组、Y-27632组、AU+Y-27632组,测量肿瘤质量与体积,免疫组化法检测移植瘤组织RhoA、ROCK1、ROCK2蛋白表达。[结果]GBM细胞活力随着AU浓度的升高而逐渐降低(P<0.05),选择U87作为后续实验细胞,选择10、25、50μmol/L浓度作为AU后续实验浓度。与对照组比较,AU低、中、高浓度组和Y-27632组细胞活力、迁移和侵袭细胞数、MMP2、MMP9、N-cadherin、Vimentin、RhoA、ROCK1、ROCK2表达显著下降,凋亡率、E-cadherin表达显著升高(P<0.05),其中高浓度AU和Y-27632组共同处理的细胞变化更显著(P<0.05)。AU和Y-27632均能抑制移植瘤质量和体积,降低RhoA/ROCK信号通路蛋白表达(P<0.05)。[结论]AU能抑制GBM细胞活力、迁移侵袭和EMT,促进细胞凋亡,其作用机制可能与抑制RhoA/ROCK信号通路有关。 展开更多
关键词 胶质母细胞瘤 细胞活力 上皮间质转化 桃叶珊瑚苷 RhoA/rock信号通路
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Characteristics and dynamic analysis of the February 2021 long-runout disaster chain triggered by massive rock and ice avalanche at Chamoli, Indian Himalaya
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作者 Tiantian Zhang Yueping Yin +5 位作者 Bin Li Xiaojie Liu Meng Wang Yang Gao Jiawei Wan Kaushal Raj Gnyawali 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2023年第2期296-308,共13页
A massive rock and ice avalanche occurred on the western slope of the Ronti Gad valley in the northern part of Chamoli,Indian Himalaya,on 7 February 7,2021.The avalanche on the high mountain slope at an elevation of 5... A massive rock and ice avalanche occurred on the western slope of the Ronti Gad valley in the northern part of Chamoli,Indian Himalaya,on 7 February 7,2021.The avalanche on the high mountain slope at an elevation of 5600 m above sea level triggered a long runout disaster chain,including rock mass avalanche,debris avalanche,and flood.The disaster chain had a horizontal travel distance of larger than 17,600 m and an elevation difference of 4300 m.In this study,the disaster characteristics and dynamic process were analyzed by multitemporal satellite imagery.The results show that the massive rock and ice avalanche was caused by four large expanding discontinuity planes.The disaster chain was divided into five zones by satellite images and field observation,including source zone,transition zone,dynamic entrainment zone,flow deposition zone,and flood zone.The entrainment effect and melting water were recognized as the main causes of the long-runout distance.Based on the seismic wave records and field videos,the time progress of the disaster was analyzed and the velocity of frontal debris at different stages was calculated.The total analyzed disaster duration was 1247 s,and the frontal debris velocity colliding with the second hydropower station was approximately 23 m/s.This study also carried out the numerical simulation of the disaster by rapid mass movement simulation(RAMMS).The numerical results reproduced the dynamic process of the debris avalanche,and the mechanism of long-runout avalanche was further verified by parametric study.Furthermore,this study discussed the potential causes of disaster and flood and the roles of satellite images and seismic networks in the monitoring and early-warning. 展开更多
关键词 rock and ice avalanche Disaster chain Long-runout ENTRAINMENT Flood
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艾灸联合保真汤加减治疗糖尿病肾病的疗效观察及对CT灌注参数、Rho/ROCK信号通路蛋白的影响
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作者 赵小艳 王俊杰 《上海针灸杂志》 CSCD 2024年第1期17-23,共7页
目的 观察艾灸联合保真汤加减治疗糖尿病肾病气阴两虚证的临床疗效及对CT灌注参数、Rho/ROCK信号通路蛋白的影响。方法 将146例糖尿病肾病气阴两虚证患者随机分为观察组(74例)和对照组(72例)。在对症治疗的基础上,对照组给予厄贝沙坦片... 目的 观察艾灸联合保真汤加减治疗糖尿病肾病气阴两虚证的临床疗效及对CT灌注参数、Rho/ROCK信号通路蛋白的影响。方法 将146例糖尿病肾病气阴两虚证患者随机分为观察组(74例)和对照组(72例)。在对症治疗的基础上,对照组给予厄贝沙坦片,观察组给予艾灸联合保真汤加减。观察两组中医主症积分、CT灌注参数[血尿素氮(blood urea nitrogen, BUN)、血肌酐(serum creatinine, SCr)、尿白蛋白排泄率(urinary albumin excretion rate, UAER)和24 h尿蛋白定量(24-hour urinary protein quantification, 24 h Upro)]、肾血流指标[舒张末期血流速度(end-diastolic velocity, EDV)、肾段动脉的收缩期峰值流速(peak-systolic velocity, PSV)、搏动指数(pulsatility index, PI)和阻力指数(resistive index, RI)]、血清炎性因子[肿瘤坏死因子-α(tumor necrosis factor-α, TNF-α)、白细胞介素-1β(interleukin-1β, IL-1β)、白细胞介素-6(interleukin-6, IL-6)和C反应蛋白(C-reactive protein, CRP)]水平及Rho/ROCK信号通路[Ras同源基因家族成员A(Ras homolog gene family member A, RhoA)、Rho关联含卷曲螺旋蛋白激酶Ⅰ(Rho-associated coiled-coil containing protein kinaseⅠ, ROCKI)、α-平滑肌肌动蛋白(α-smooth muscle actin, α-SMA)和钙黏附蛋白-E(E-cadherin, E-Cad)]蛋白水平,并比较两组临床疗效及不良反应。结果 观察组总有效率为97.3%(72/74),明显高于对照组的81.9%(59/72)(P<0.05)。观察组治疗后中医主症积分低于治疗前和对照组(P<0.05)。两组治疗后CT灌注参数降低(P<0.05),且观察组低于对照组(P<0.05)。观察组治疗后PSV、EDV较治疗前和对照组加快(P<0.05),RI、PI较治疗前和对照组降低(P<0.05)。观察组治疗后血清炎性因子水平较治疗前和对照组降低(P<0.05)。观察组治疗后Rho A、ROCKI、α-SMA蛋白水平较治疗前和对照组降低(P<0.05),E-Cad蛋白水平较治疗前和对照组升高(P<0.05)。观察组不良反应发生率为1.4%(1/74),低于对照组的19.4%(14/72)(P<0.05)。结论 在对症治疗的基础上,艾灸联合保真汤加减可明显提高糖尿病肾病气阴两虚证患者的治疗效果,其机制可能与改善CT灌注参数,调节血清Rho/ROCK信号通路蛋白相关。 展开更多
关键词 灸法 糖尿病并发症 糖尿病肾病 气阴两虚 Rho/rock信号通路蛋白
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黄芩苷通过ROS依赖性调节RhoA/ROCK通路保护氯化钴诱导心肌细胞损伤的实验研究
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作者 沈艳玲 刘承红 +3 位作者 王世魁 徐尧 张云波 顾申红 《海南医学院学报》 CAS 2024年第7期481-488,共8页
目的:本研究旨在探讨黄芩苷(Baicalin)对氯化钴(CoCl_(2))诱导H9c2心肌细胞缺氧损伤的作用机制。方法:采用CoCl_(2)建立心肌细胞缺氧损伤模型,并分别加入不同浓度的黄芩苷培养。将正常氧培养设置为对照组,CoCl_(2)培养H9c2心肌细胞设置... 目的:本研究旨在探讨黄芩苷(Baicalin)对氯化钴(CoCl_(2))诱导H9c2心肌细胞缺氧损伤的作用机制。方法:采用CoCl_(2)建立心肌细胞缺氧损伤模型,并分别加入不同浓度的黄芩苷培养。将正常氧培养设置为对照组,CoCl_(2)培养H9c2心肌细胞设置为CoCl_(2)组;Baicalin、Y27632(Rho激酶抑制剂)预处理的H9c2缺氧心肌细胞设置为CoCl_(2)+Baicalin组、CoCl_(2)+Y27632组、CoCl_(2)+Baicalin+Y27632组。通过细胞毒性检测试剂盒(CCK8)检测细胞活性;荧光探针测定细胞中活性氧(ROS)的表达;WST-8检测心肌细胞超氧化歧化酶(SOD)活力;TBA法测定丙二醇(MDA)浓度;同时采用WesternBlot方法分析RhoA、ROCK1、ROCK2、TNF-α、IL-1β蛋白表达情况。结果:处理H9c2细胞24 h后,1 000μmol/L的CoCl_(2)和75μmol/L黄芩苷对治疗心肌细胞缺氧损伤具有较好的细胞活力。CoCl_(2)组细胞活性明显低于对照组,加入黄芩苷后可显著提高细胞活性(P<0.05);与对照组相比,CoCl_(2)组心肌细胞可上调ROS、MDA表达,下调SOD活力,升高RhoA、ROCK1、ROCK2、TNF-α、IL-1β蛋白表达水平,加入Baicalin后可逆转上诉蛋白的表达水平;与CoCl_(2)组相比,CoCl_(2)+Baicalin可抑制ROS、MDA的表达,上调SOD含量,下调RhoA、ROCK1、ROCK2、TNF-α、IL-1β蛋白表达水平,而加入Y27632(Rho激酶抑制剂)后则可显著增强Baicalin带来的保护作用。结论:Baicalin可减轻CoCl_(2)诱导H9c2心肌细胞缺氧损伤的炎症、氧化应激反应,其机制与抑制ROS依赖性RhoA/ROCK通路有关。 展开更多
关键词 黄芩苷 RhoA/Rho相关激酶(rock)信号通路 缺氧损伤模型
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炎调方调控Rho/ROCK信号通路对脓毒症急性胃肠损伤小鼠肠上皮细胞凋亡的研究
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作者 陈乾 王帝 +5 位作者 张定一 贾赛蕾 王丽辉 曹玉净 李鲜 李燕红 《中国比较医学杂志》 CAS 2024年第2期16-24,共9页
目的探讨炎调方调控Rho/ROCK信号通路对脓毒症急性胃肠损伤小鼠肠上皮细胞凋亡的影响。方法取70只BALB/c小鼠随机分为空白组、假手术组和造模小鼠。除空白组、假手术组外,各组小鼠均采用盲肠结扎穿孔术(cecum ligation and puncture,CLP... 目的探讨炎调方调控Rho/ROCK信号通路对脓毒症急性胃肠损伤小鼠肠上皮细胞凋亡的影响。方法取70只BALB/c小鼠随机分为空白组、假手术组和造模小鼠。除空白组、假手术组外,各组小鼠均采用盲肠结扎穿孔术(cecum ligation and puncture,CLP)构建脓毒症急性胃肠损伤小鼠模型,将造模成功的小鼠随机分为模型组、炎调方低、中、高剂量组和ROCK抑制剂组。采用HE染色观察小鼠回肠组织病理学改变;ELISA法检测各组小鼠血清IL-1β、IL-6、TNF-α、IL-10水平;免疫组织化学检测观察PCNA、Ki-67的表达;蛋白印迹法检测回肠组织凋亡指标cleaved caspase3蛋白、Bax蛋白表达;RT-qPCR检测小鼠回肠组织ROCK mRNA、MLC mRNA表达。结果较空白组和假手术组相比,模型组小鼠的Chiu’s病理评分、促炎介质(IL-1β、IL-6、TNF-α)水平、cleaved caspase3蛋白、Bax蛋白、ROCK mRNA、MLC mRNA水平升高(P<0.05),而抑炎介质(IL-10)水平和回肠组织中PCNA、Ki-67表达降低(P<0.05)。与模型组比较,炎调方各组随着剂量增加,回肠组织病理学改变均得到不同程度改善,其Chiu’s病理评分、血清中IL-1β、IL-6、TNF-α水平、cleaved caspase3蛋白、Bax蛋白、ROCK mRNA、MLC mRNA的表达降低(P<0.05),而IL-10水平、回肠组织中PCNA、Ki-67表达升高(P<0.05)。结论炎调方可能通过调控Rho/ROCK信号通路抑制脓毒症急性胃肠损伤小鼠的肠上皮细胞凋亡,从而具有减轻肠道组织炎症反应,最终达到防止肠黏膜组织损伤的作用。 展开更多
关键词 脓毒症急性胃肠损伤 肠上皮细胞凋亡 RHO/rock信号通路 炎调方
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Numerical simulation for the initial state of avalanche in polydisperse particle systems
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作者 韩韧 李亭 +2 位作者 迟志鹏 杨晖 李然 《Chinese Physics B》 SCIE EI CAS CSCD 2024年第2期405-412,共8页
Numerical simulation is employed to investigate the initial state of avalanche in polydisperse particle systems.Nucleation and propagation processes are illustrated for pentadisperse and triadisperse particle systems,... Numerical simulation is employed to investigate the initial state of avalanche in polydisperse particle systems.Nucleation and propagation processes are illustrated for pentadisperse and triadisperse particle systems,respectively.In these processes,particles involved in the avalanche grow slowly in the early stage and explosively in the later stage,which is clearly different from the continuous and steady growth trend in the monodisperse system.By examining the avalanche propagation,the number growth of particles involved in the avalanche and the slope of the number growth,the initial state can be divided into three stages:T1(nucleation stage),T2(propagation stage),T3(overall avalanche stage).We focus on the characteristics of the avalanche in the T2 stage,and find that propagation distances increase almost linearly in both axial and radial directions in polydisperse systems.We also consider the distribution characteristics of the average coordination number and average velocity for the moving particles.The results support that the polydisperse particle systems are more stable in the T2 stage. 展开更多
关键词 avalanche initial state polydisperse particle systems PROPAGATION
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束缚应激通过激活Rho/ROCK通路诱导大鼠杏仁核血脑屏障的损伤
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作者 许光明 高安迪 丛斌 《南方医科大学学报》 CAS CSCD 2024年第3期411-419,共9页
目的探讨Rho/ROCK信号通路在束缚应激诱导大鼠杏仁核血脑屏障损伤过程中的作用及机制。方法选取60只SPF级雄性SD大鼠建立束缚应激模型,将大鼠分为4组:Control组(n=15,每日禁食水6 h);Stress组(n=15,每日束缚6 h);Stress+Fasudil组(n=15... 目的探讨Rho/ROCK信号通路在束缚应激诱导大鼠杏仁核血脑屏障损伤过程中的作用及机制。方法选取60只SPF级雄性SD大鼠建立束缚应激模型,将大鼠分为4组:Control组(n=15,每日禁食水6 h);Stress组(n=15,每日束缚6 h);Stress+Fasudil组(n=15,每日束缚6 h,束缚前0.5 h给予腹腔注射1 mg/100 g Fasudil溶液);Fasudil组(n=15,每日给予腹腔注射1 mg/100 g Fasudil溶液)。用高架十字迷宫实验(EPM)检测各组大鼠行为学变化,ELISA检测血清CORT和S100B水平,检测脑组织伊文思蓝(EB)的渗漏情况以评估渗透性的改变,免疫荧光法和Western blotting方法检测紧密连接蛋白Claudin-5、Occludin、ZO-1的表达变化,Pull-down实验和Western blotting检测Rho/ROCK通路的激活情况,透射电镜观察脑微血管内皮细胞超微结构的形态变化。结果与Control组相比,Stress组和Stress+Fasudil组大鼠表现出了明显的焦虑样行为;Stress组和Stress+Fasudil组血清CORT含量均显著高于Control组(P<0.001);与Control组和Stress+Fasudil组相比,Stress组EB渗漏含量和S100B含量均显著升高(P<0.05);Stress组紧密连接蛋白的表达显著低于Control组和Stress+Fasudil组(P<0.05);Pull-down实验和Western blot分析证实,Stress组RhoA-GTP(P<0.001)、ROCK2(P<0.001)、p-MLC2(P<0.05)的表达显著高于Control组和Stress+Fasudil组;脑微血管内皮细胞超微结构显示,Stress组呈现显著的形态学改变。结论束缚应激能够通过激活Rho/ROCK信号通路诱导大鼠杏仁核血脑屏障的损伤。 展开更多
关键词 束缚应激 血脑屏障 杏仁核 Rho/rock通路 紧密连接 渗透性
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Development and applications of the quasi‐dynamic triaxial apparatus for deep rocks
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作者 Jinzhi Luo Yanyan Cai +3 位作者 Jin Yu Jianzhi Zhang Yaoliang Zhu Yao Wei 《Deep Underground Science and Engineering》 2024年第1期70-90,共21页
The mechanical behaviors of deep rocks have always posed a challenge for the implementation and safe operation of major underground engineering projects.To this end,this study modified the existing mainstream rock mec... The mechanical behaviors of deep rocks have always posed a challenge for the implementation and safe operation of major underground engineering projects.To this end,this study modified the existing mainstream rock mechanics instruments equipped with a dynamic disturbance loading system and developed a second‐generation TFD‐2000/D triaxial instrument.The first‐generation device is equipped with an independent disturbance system and an advanced EDC‐580 all‐digital servo controller,which can apply disturbing load independently,implement the function of cyclic disturbance,and combine dynamic and static disturbances.The instrument was found to be reliable for use in analyzing the damage process of rocks in the disturbance test of marbles.The second‐generation instrument tackles three limitations of the first‐generation instrument:(i)it upgrades the strain measurement system and uses extensometers with linear variable differential transformers to accurately measure deformation;(ii)it uses the self‐balanced chamber to replace the Hoek–Franklin triaxial cell and auto‐balancing triaxial pressure chamber;and(iii)the loading rod is independently equipped with an EDC‐580 all‐digital servo controller,which measures precise loads.The experimental findings confirmed that the second‐generation instrument can be used for rock mechanics testing under cyclic disturbance loading,the disturbance–stress relaxation cycle,and the creep–fatigue cycle.In this sense,the second‐generation instrument can be a useful addition to deep rock mechanical instruments and provide a valuable reference. 展开更多
关键词 complex stress conditions deep rock disturbance loading modification of instrument rock mechanics
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Creep constitutive model considering nonlinear creep degradation of fractured rock
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作者 Wang Chunping Liu Jianfeng +3 位作者 Chen Liang Liu Jian Wang Lu Liao Yilin 《International Journal of Mining Science and Technology》 SCIE EI CAS CSCD 2024年第1期105-116,共12页
Stability analysis of underground constructions requires a model study of rock masses’ long-term performance. Creep tests under different stress conditions was conducted on intact granite and granite samples fracture... Stability analysis of underground constructions requires a model study of rock masses’ long-term performance. Creep tests under different stress conditions was conducted on intact granite and granite samples fractured at 30° and 45° angles. The experimental results indicate that the steady creep strain rates of intact and fractured rock present an exponential increase trend with the increase of stress level. A nonlinear creep model is developed based on the experimental results, in which the initial damage caused by fracture together with the damage caused by constant load have been taken into consideration. The fitting analysis results indicated that the model proposed is more accurate at identifying the full creep regions in fractured granite, especially the accelerated stage of creep deformation. The least-square fit error of the proposed creep model is significantly lower than that of Nishihara model by almost an order of magnitude. An analysis of the effects of elastic modulus, viscosity coefficient, and damage factors on fractured rock strain rate and creep strain is conducted. If no consideration is given to the effects of the damage, the proposed nonlinear creep model can degenerate into to the classical Nishihara model. 展开更多
关键词 Fractured rock DAMAGE CREEP Beishan granite Geological disposal
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Topographic seismic effects and avalanche hazard:A case study of Mount Siella(L’Aquila,Central Italy)
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作者 Ferdinando TOTANI 《Journal of Mountain Science》 SCIE CSCD 2024年第2期662-675,共14页
In mountainous areas,snow avalanches could be triggered by the shaking produced by earthquakes.The forces induced by the earthquake can cause an irregular increase of shear strength load down the slope,for the presenc... In mountainous areas,snow avalanches could be triggered by the shaking produced by earthquakes.The forces induced by the earthquake can cause an irregular increase of shear strength load down the slope,for the presence of complex surface and buried morphologies.Topographic irregularities generate maximum effects of waves amplification linked to wavelengths comparable to the horizontal dimension of the topographic feature.For this reason,the selected time-histories represent an appropriate input for the two-dimensional numerical response analyses when a dynamic phenomenon produce the resonant motion of a whole mountain.This represents an important earthquake-induced hazard in snow-covered mountain areas with high probability of seismic events.Some valleys are located in regions with scare ground motion data and investments on infrastructures are not always accompanied by adequate protection against earthquake-induced avalanches.The paper points out a simple deterministic approach for selecting a set of real accelerograms applied to a real case of Siella Mountain(Central Italy)where a large avalanche destroying a tourist facility of Rigopiano resort on 18 January 2017.The selected time histories were used as input for the two-dimensional numerical model of the subsoil to evaluate the topographic seismic amplification in ridge and compare it with the results of other authors.These methods suggest that morphology-related inertial effects should be considered as an overload action on snow layers when controlling multi-hazard studies and spatial planning. 展开更多
关键词 Real accelerograms selection Deterministic approach Topographic amplification avalanche induced by earthquake 2D seismic response.
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Pulses in ground motions identified through surface partial matching and their impact on seismic rocking consequence
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作者 Tang Yuchuan Wang Jiankang Wu Gang 《Earthquake Engineering and Engineering Vibration》 SCIE EI CSCD 2024年第1期35-50,共16页
In seismology and earthquake engineering,it is fundamental to identify and characterize the pulse-like features in pulse-type ground motions.To capture the pulses that dominate structural responses,this study establis... In seismology and earthquake engineering,it is fundamental to identify and characterize the pulse-like features in pulse-type ground motions.To capture the pulses that dominate structural responses,this study establishes congruence and shift relationships between response spectrum surfaces.A similarity search between spectrum surfaces,supplemented with a similarity search in time series,has been applied to characterize the pulse-like features in pulse-type ground motions.The identified pulses are tested in predicting the rocking consequences of slender rectangular blocks under the original ground motions.Generally,the prediction is promising for the majority of the ground motions where the dominant pulse is correctly identified. 展开更多
关键词 velocity pulse ground motion surface similarity rockING OVERTURNING
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A detailed rock density model of the Hong Kong territories
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作者 Albertini Nsiah Ababio Robert Tenzer 《Geodesy and Geodynamics》 EI CSCD 2024年第1期75-81,共7页
We used the geological map and published rock density measurements to compile the digital rock density model for the Hong Kong territories.We then estimated the average density for the whole territory.According to our... We used the geological map and published rock density measurements to compile the digital rock density model for the Hong Kong territories.We then estimated the average density for the whole territory.According to our result,the rock density values in Hong Kong vary from 2101 to 2681 kg·m^(-3).These density values are typically smaller than the average density of 2670 kg·m^(-3),often adopted to represent the average density of the upper continental crust in physical geodesy and gravimetric geophysics applications.This finding reflects that the geological configuration in Hong Kong is mainly formed by light volcanic formations and lava flows with overlying sedimentary deposits at many locations,while the percentage of heavier metamorphic rocks is very low(less than 1%).This product will improve the accuracy of a detailed geoid model and orthometric heights. 展开更多
关键词 Density model rock types Gravimetric modeling Hong Kong
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Investigation of anisotropic strength criteria for layered rock mass
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作者 Shuling Huang Jinxin Zhang +4 位作者 Xiuli Ding Chuanqing Zhang Gang Han Guoqi Yu Lulu Qu 《Journal of Rock Mechanics and Geotechnical Engineering》 SCIE CSCD 2024年第4期1289-1304,共16页
Layered rock mass is a type of engineering rock mass with sound mechanical anisotropy,which is generally unfavorable to the stability of underground works.To investigate the strength anisotropy of layered rock,the Moh... Layered rock mass is a type of engineering rock mass with sound mechanical anisotropy,which is generally unfavorable to the stability of underground works.To investigate the strength anisotropy of layered rock,the Mohr-Coulomb and Hoek-Brown criteria are introduced to establish the two transverse isotropic strength criteria based on Jaeger's single weak plane theory and maximum axial strain theory,and parameter determination methods.Furthermore,the sensitivity of strength parameters(K 1,K 2,and K 3)that are used to characterize the anisotropy strength of non-sliding failure involved in the strength criteria and confining pressure are investigated.The results demonstrate that strength parameters K 1 and K 2 affect the strength of layered rock samples at all bedding angles except for the bedding angle of 90°and the angle range that can cause the shear sliding failure along the bedding plane.The strength of samples at any bedding angle decreases with increasing K 1,whereas the opposite is for K 2.Except for bedding angles of 0°and 90°and the bedding angle range that can cause the shear sliding along the bedding plane,K 3 has an impact on the strength of rock samples with other bedding angles that the specimens'strength increases with increase of K 3.In addition,the strength of the rock sample increases as confining pressure rises.Furthermore,the uniaxial and triaxial tests of chlorite schist samples were carried out to verify and evaluate the strength criteria proposed in the paper.It shows that the predicted strength is in good agreement with the experimental results.To test the applicability of the strength criterion,the strength data of several types of rock in the literature are compared.Finally,a comparison is made between the fitting effects of the two strength criteria and other available criteria for layered rocks. 展开更多
关键词 Layered rock Strength anisotropy Strength criterion Experimental verification
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