BACKGROUND Sebaceous carcinoma(SC),a malignancy primarily characterized by aggressive growth,affects cutaneous tissues of the periocular region.Extraocular SC is extremely rare,especially in the extremities,as evidenc...BACKGROUND Sebaceous carcinoma(SC),a malignancy primarily characterized by aggressive growth,affects cutaneous tissues of the periocular region.Extraocular SC is extremely rare,especially in the extremities,as evidenced by only a handful of reported cases.CASE SUMMARY A 65-year-old man presented with a rapidly enlarging swelling on the left inner thigh,which was initially misdiagnosed as a subcutaneous abscess.The lesion had appeared two months prior to admission.Clinical examination revealed a cauliflower-like swollen content,with an ulcerated and infected mass located on his left thigh.At the same time,we observed solitary nodular lesions in his lungs and brain,with biopsy pathology of the lung lesions found to be consistent with the mass in the thigh.The patient received chemotherapy comprising cis-platinum with fluorouracil,followed by targeted therapy with anlotinib hydrochloride and chemotherapy with vinorelbine,implantation of iodine-125 seeds in the thigh and pulmonary tumor.The initial stage intervention achieved partial remission.The efficacy of maintenance treatment was evaluated as stable disease after the first 5 cycles;however,the patient developed a new brain lesion after the sixth cycle of treatment,which resulted in progressive disease and he received whole brain gamma knife radiotherapy.CONCLUSION We analyzed the clinical presentation,imaging features,pathology and treatment of a rare case of lung,brain and lymph node metastasis of SC located in the thigh.It is evident that cis-platinum combined with fluorouracil,vinorelbine combined with anlotinib hydrochloride may be an effective therapeutic regimen in advanced SC.However,brain metastatic lesions should receive early radiotherapy.展开更多
AIM: To describe the histopathologic and clinical features of eyelid tumor cases from Tianjin Eye Hospital during 2002 to 2015. METHODS: In this retrospective study, a total of 2228 cases of eyelid tumors with patholo...AIM: To describe the histopathologic and clinical features of eyelid tumor cases from Tianjin Eye Hospital during 2002 to 2015. METHODS: In this retrospective study, a total of 2228 cases of eyelid tumors with pathologic diagnoses were enrolled. The eyelid tumors were classified into three groups according to tumor origin: epidermal, adnexal and miscellaneous, including melanocytic, neural and vascular lesions. Inflammatory tumor-like lesions were excluded. The clinical characteristics of the eyelid tumors were analyzed, including age, gender and lesion location. RESULTS: Most eyelid tumors were epidermal in origin(1080, 48.5%), followed by miscellaneous(885, 39.7%) and adnexal tumors(263, 11.8%). Among all the tumors, 292(13.1%) were malignant lesions, 1910(85.7%) benign and 26(1.1%) premalignant lesions. Most malignant tumors originated from epidermal cells(60.0%), followed by adnexal cells(34.6%). The most common malignant tumors were basal cell carcinomas(56.5%) followed by sebaceous carcinoma(34.6%), squamous cell carcinomas(3.8%) and lymphoma/plasmocytoma(1.7%). The benign and premalignant eyelid lesions mostly originated from epidermal cells(46.4%) followed by miscellaneous cell sources(45.2%), including melanocytic nevus(33.8%), seborrheic keratosis(13.7%), squamous cell papilloma(13.0%) and epidermal cysts(11.5%). CONCLUSION: Eyelid tumors are mostly epithelial in origin. Benign tumors are significantly more common than malignant tumors with an obvious female predominance, and the most frequent malignant tumor are basal cell carcinoma, sebaceous carcinoma and squamous cell carcinomas. The tumor clinical features varied among the different subtypes.展开更多
文摘BACKGROUND Sebaceous carcinoma(SC),a malignancy primarily characterized by aggressive growth,affects cutaneous tissues of the periocular region.Extraocular SC is extremely rare,especially in the extremities,as evidenced by only a handful of reported cases.CASE SUMMARY A 65-year-old man presented with a rapidly enlarging swelling on the left inner thigh,which was initially misdiagnosed as a subcutaneous abscess.The lesion had appeared two months prior to admission.Clinical examination revealed a cauliflower-like swollen content,with an ulcerated and infected mass located on his left thigh.At the same time,we observed solitary nodular lesions in his lungs and brain,with biopsy pathology of the lung lesions found to be consistent with the mass in the thigh.The patient received chemotherapy comprising cis-platinum with fluorouracil,followed by targeted therapy with anlotinib hydrochloride and chemotherapy with vinorelbine,implantation of iodine-125 seeds in the thigh and pulmonary tumor.The initial stage intervention achieved partial remission.The efficacy of maintenance treatment was evaluated as stable disease after the first 5 cycles;however,the patient developed a new brain lesion after the sixth cycle of treatment,which resulted in progressive disease and he received whole brain gamma knife radiotherapy.CONCLUSION We analyzed the clinical presentation,imaging features,pathology and treatment of a rare case of lung,brain and lymph node metastasis of SC located in the thigh.It is evident that cis-platinum combined with fluorouracil,vinorelbine combined with anlotinib hydrochloride may be an effective therapeutic regimen in advanced SC.However,brain metastatic lesions should receive early radiotherapy.
文摘AIM: To describe the histopathologic and clinical features of eyelid tumor cases from Tianjin Eye Hospital during 2002 to 2015. METHODS: In this retrospective study, a total of 2228 cases of eyelid tumors with pathologic diagnoses were enrolled. The eyelid tumors were classified into three groups according to tumor origin: epidermal, adnexal and miscellaneous, including melanocytic, neural and vascular lesions. Inflammatory tumor-like lesions were excluded. The clinical characteristics of the eyelid tumors were analyzed, including age, gender and lesion location. RESULTS: Most eyelid tumors were epidermal in origin(1080, 48.5%), followed by miscellaneous(885, 39.7%) and adnexal tumors(263, 11.8%). Among all the tumors, 292(13.1%) were malignant lesions, 1910(85.7%) benign and 26(1.1%) premalignant lesions. Most malignant tumors originated from epidermal cells(60.0%), followed by adnexal cells(34.6%). The most common malignant tumors were basal cell carcinomas(56.5%) followed by sebaceous carcinoma(34.6%), squamous cell carcinomas(3.8%) and lymphoma/plasmocytoma(1.7%). The benign and premalignant eyelid lesions mostly originated from epidermal cells(46.4%) followed by miscellaneous cell sources(45.2%), including melanocytic nevus(33.8%), seborrheic keratosis(13.7%), squamous cell papilloma(13.0%) and epidermal cysts(11.5%). CONCLUSION: Eyelid tumors are mostly epithelial in origin. Benign tumors are significantly more common than malignant tumors with an obvious female predominance, and the most frequent malignant tumor are basal cell carcinoma, sebaceous carcinoma and squamous cell carcinomas. The tumor clinical features varied among the different subtypes.
