Static secure techniques, such as firewall, hierarchy filtering, distributed disposing,layer management, autonomy agent, secure communication, were introduced in distributed intrusion detection. The self-protection ag...Static secure techniques, such as firewall, hierarchy filtering, distributed disposing,layer management, autonomy agent, secure communication, were introduced in distributed intrusion detection. The self-protection agents were designed, which have the distributed architecture,cooperate with the agents in intrusion detection in a loose-coupled manner, protect the security of intrusion detection system, and respond to the intrusion actively. A prototype self-protection agent was implemented by using the packet filter in operation system kernel. The results show that all the hosts with the part of network-based intrusion detection system and the whole intrusion detection system are invisible from the outside and network scanning, and cannot apperceive the existence of network-based intrusion detection system. The communication between every part is secure. In the low layer, the packet streams are controlled to avoid the buffer leaks exist ing in some system service process and back-door programs, so as to prevent users from misusing and vicious attack like Trojan Horse effectively.展开更多
Based on large numbers of experiments, together with some theoretic support such as equations related to the experiment, thermodynamic principles and so on, one useful and reasonable self-protecting boron formulation ...Based on large numbers of experiments, together with some theoretic support such as equations related to the experiment, thermodynamic principles and so on, one useful and reasonable self-protecting boron formulation is got to reinforce the muzzle shunt rail gun rail. The preliminary friction and abrasion test results show that the formulation is acceptable and the abrasion resistance of the steel rail enhances to some extent after the surface reinforcement.展开更多
Erythrocyte membrane(EM)-camouflaged chemotherapeutic delivery nanovehicles hold promise for solid tumor therapy because of their excellent biostability and biocompatibility. However, it is accompanied with insufficie...Erythrocyte membrane(EM)-camouflaged chemotherapeutic delivery nanovehicles hold promise for solid tumor therapy because of their excellent biostability and biocompatibility. However, it is accompanied with insufficient targeting effect and deficient pharmacokinetic behavior due to the lack of a regulated biointerface to navigate and overcome biological transportation obstacles in solid tumor therapy.Herein, an anti-epidermal growth factor receptor(EGFR) aptamer(EApt) modified and EM-cloaked chemotherapeutic nanomissile delivery system was constructed. The anchored-EApt acting as a specific EGFR suppressor promotes to inhibit the overexpression of EGFR and initiate the cell apoptosis. Importantly, the resulting PLGA-DOX@EM-EApt orchestrated the bioactivity of each component and provided synergistic cell apoptosis and antitumor effects by precisely suppressing EGFR expression levels and delivering DOX. The in vitro and in vivo experimental results confirmed that the immune escape and active targeting behaviors of PLGA-DOX@EM-EApt could significantly promote its drug retention and tumor inhibition abilities. Our findings propose a novel strategy using the biointerface functionalization technique, demonstrating a promising therapeutic platform via a biomimetic drug delivery system for precise solid tumor recognition and synergistic therapy.展开更多
This paper mainly studies the optimal investment problem of defined contribution(DC)pension under the self-protection and minimum security.First,we apply Ito?theorem to obtain the differential equation of the real sto...This paper mainly studies the optimal investment problem of defined contribution(DC)pension under the self-protection and minimum security.First,we apply Ito?theorem to obtain the differential equation of the real stock price after discounting inflation.Then,under the constraint of external guarantee of DC pension terminal wealth,self-protection is introduced to study the maximization of the expected utility of terminal wealth at retirement time and any time before retirement.The explicit solution of the optimal investment strategy of DC pension at retirement time and any time before retirement should be derived by martingale method.Finally,the influence of selfprotection on the optimal investment strategy of DC pension is numerically analyzed.展开更多
Among the factors which restrict the large-scale utilization of magnesium-based hydride as a hydrogen storage medium,the high operating temperature,slow kinetics,and air stability in particular are key obstacles.In th...Among the factors which restrict the large-scale utilization of magnesium-based hydride as a hydrogen storage medium,the high operating temperature,slow kinetics,and air stability in particular are key obstacles.In this work,a novel method,namely hydriding combustion synthesis plus short-term mechanical milling followed by air exposure,was proposed to synthesize air stable and autocatalytic magnesium nickel hydride(Mg2NiH4),which shows excellent hydrogen absorption/desorption kinetics,capacity retention and oxidation resistance.The short-term-milled Mg2NiH4 can desorb 2.97 wt.%hydrogen within 500 s at 230℃.Even after exposure under air atmosphere for 67 days,it can still desorb 2.88 wt.%hydrogen within 500 s at 230℃.The experimental and theoretical results both indicated that the surface of as-milled Mg2NiH4 was easy to be oxidized under air atmosphere.However,the in-situ formed Ni during air exposure of Mg2NiH4 improved the hydrogen desorption kinetics,and the formed surface passivation layer maintained the hydrogen storage capacity and avoided further poisoning,which we called autocatalytic and self-protective effect.Such a novel dual effect modified the reaction activity and oxidation resistance of the air-exposed Mg2NiH4.Our findings provide useful insights into the design and preparation of air stable metal-based hydride for large-scale utilization and long-term storage.展开更多
文摘Static secure techniques, such as firewall, hierarchy filtering, distributed disposing,layer management, autonomy agent, secure communication, were introduced in distributed intrusion detection. The self-protection agents were designed, which have the distributed architecture,cooperate with the agents in intrusion detection in a loose-coupled manner, protect the security of intrusion detection system, and respond to the intrusion actively. A prototype self-protection agent was implemented by using the packet filter in operation system kernel. The results show that all the hosts with the part of network-based intrusion detection system and the whole intrusion detection system are invisible from the outside and network scanning, and cannot apperceive the existence of network-based intrusion detection system. The communication between every part is secure. In the low layer, the packet streams are controlled to avoid the buffer leaks exist ing in some system service process and back-door programs, so as to prevent users from misusing and vicious attack like Trojan Horse effectively.
文摘Based on large numbers of experiments, together with some theoretic support such as equations related to the experiment, thermodynamic principles and so on, one useful and reasonable self-protecting boron formulation is got to reinforce the muzzle shunt rail gun rail. The preliminary friction and abrasion test results show that the formulation is acceptable and the abrasion resistance of the steel rail enhances to some extent after the surface reinforcement.
基金supported by the National Natural Science Foundation of China (Nos. 82073807 and 81973277)the WorldClass Universities (Disciplines)the Characteristic Development Guidance Funds for the Central Universities,China (No. PY3A012)。
文摘Erythrocyte membrane(EM)-camouflaged chemotherapeutic delivery nanovehicles hold promise for solid tumor therapy because of their excellent biostability and biocompatibility. However, it is accompanied with insufficient targeting effect and deficient pharmacokinetic behavior due to the lack of a regulated biointerface to navigate and overcome biological transportation obstacles in solid tumor therapy.Herein, an anti-epidermal growth factor receptor(EGFR) aptamer(EApt) modified and EM-cloaked chemotherapeutic nanomissile delivery system was constructed. The anchored-EApt acting as a specific EGFR suppressor promotes to inhibit the overexpression of EGFR and initiate the cell apoptosis. Importantly, the resulting PLGA-DOX@EM-EApt orchestrated the bioactivity of each component and provided synergistic cell apoptosis and antitumor effects by precisely suppressing EGFR expression levels and delivering DOX. The in vitro and in vivo experimental results confirmed that the immune escape and active targeting behaviors of PLGA-DOX@EM-EApt could significantly promote its drug retention and tumor inhibition abilities. Our findings propose a novel strategy using the biointerface functionalization technique, demonstrating a promising therapeutic platform via a biomimetic drug delivery system for precise solid tumor recognition and synergistic therapy.
基金Supported by the National Social Science Foundation of China(20BTJ048)Anhui University Humanities and Social Science Research Major Project(SK2021ZD0043)。
文摘This paper mainly studies the optimal investment problem of defined contribution(DC)pension under the self-protection and minimum security.First,we apply Ito?theorem to obtain the differential equation of the real stock price after discounting inflation.Then,under the constraint of external guarantee of DC pension terminal wealth,self-protection is introduced to study the maximization of the expected utility of terminal wealth at retirement time and any time before retirement.The explicit solution of the optimal investment strategy of DC pension at retirement time and any time before retirement should be derived by martingale method.Finally,the influence of selfprotection on the optimal investment strategy of DC pension is numerically analyzed.
基金the National Natural Science Foundation of China(Nos.51771092,52071177,and 21975125)Six Talent Peaks Project in Jiangsu Province(No.2018-XNY-020)the Priority Academic Program Development(PAPD)of Jiangsu Higher Education Institutions.
文摘Among the factors which restrict the large-scale utilization of magnesium-based hydride as a hydrogen storage medium,the high operating temperature,slow kinetics,and air stability in particular are key obstacles.In this work,a novel method,namely hydriding combustion synthesis plus short-term mechanical milling followed by air exposure,was proposed to synthesize air stable and autocatalytic magnesium nickel hydride(Mg2NiH4),which shows excellent hydrogen absorption/desorption kinetics,capacity retention and oxidation resistance.The short-term-milled Mg2NiH4 can desorb 2.97 wt.%hydrogen within 500 s at 230℃.Even after exposure under air atmosphere for 67 days,it can still desorb 2.88 wt.%hydrogen within 500 s at 230℃.The experimental and theoretical results both indicated that the surface of as-milled Mg2NiH4 was easy to be oxidized under air atmosphere.However,the in-situ formed Ni during air exposure of Mg2NiH4 improved the hydrogen desorption kinetics,and the formed surface passivation layer maintained the hydrogen storage capacity and avoided further poisoning,which we called autocatalytic and self-protective effect.Such a novel dual effect modified the reaction activity and oxidation resistance of the air-exposed Mg2NiH4.Our findings provide useful insights into the design and preparation of air stable metal-based hydride for large-scale utilization and long-term storage.
