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Comparison of two statistical methods for handling missing values of quantitative data in Bayesian N-of-1 trials: a simulation study
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作者 Jing-Bo Zhai Tian-Ci Guo Wei-Jie Yu 《Medical Data Mining》 2024年第1期10-15,共6页
Background:Missing data are frequently occurred in clinical studies.Due to the development of precision medicine,there is an increased interest in N-of-1 trial.Bayesian models are one of main statistical methods for a... Background:Missing data are frequently occurred in clinical studies.Due to the development of precision medicine,there is an increased interest in N-of-1 trial.Bayesian models are one of main statistical methods for analyzing the data of N-of-1 trials.This simulation study aimed to compare two statistical methods for handling missing values of quantitative data in Bayesian N-of-1 trials.Methods:The simulated data of N-of-1 trials with different coefficients of autocorrelation,effect sizes and missing ratios are obtained by SAS 9.1 system.The missing values are filled with mean filling and regression filling respectively in the condition of different coefficients of autocorrelation,effect sizes and missing ratios by SPSS 25.0 software.Bayesian models are built to estimate the posterior means by Winbugs 14 software.Results:When the missing ratio is relatively small,e.g.5%,missing values have relatively little effect on the results.Therapeutic effects may be underestimated when the coefficient of autocorrelation increases and no filling is used.However,it may be overestimated when mean or regression filling is used,and the results after mean filling are closer to the actual effect than regression filling.In the case of moderate missing ratio,the estimated effect after mean filling is closer to the actual effect compared to regression filling.When a large missing ratio(20%)occurs,data missing can lead to significantly underestimate the effect.In this case,the estimated effect after regression filling is closer to the actual effect compared to mean filling.Conclusion:Data missing can affect the estimated therapeutic effects using Bayesian models in N-of-1 trials.The present study suggests that mean filling can be used under situation of missing ratio≤10%.Otherwise,regression filling may be preferable. 展开更多
关键词 N-of-1 trial BAYESIAN missing data simulation study
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Computer simulation studies of pulsed Doppler signals from vortices
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作者 CHEN Sizhong ,WANG Yuanyuan, WANG Weiqi (Electronic Engineering Department, Fudan University Shanghai 200433) 《Chinese Journal of Acoustics》 2001年第3期266-274,共9页
A computer simulation method for pulsed Doppler signals from vortices was pro- posed to generate simulated vortex Doppler signals under various given circumstances. The relative waveforms, such as the maximum frequenc... A computer simulation method for pulsed Doppler signals from vortices was pro- posed to generate simulated vortex Doppler signals under various given circumstances. The relative waveforms, such as the maximum frequency waveform, the mean frequency waveform and the bandwidth waveform, were obtained using the short time Fourier analysis of those simulated signals. The relations were studied between several spectrum parameters obtained from these waveforms and given simulation conditions, such as the position and the size of the sample volume, the distance between two vortices, the free stream velocity and the maximum tangent velocity of the vortex. The sensitive parameters were found to detect vortices using the pulsed Doppler techniques. 展开更多
关键词 Computer simulation studies of pulsed Doppler signals from vortices LENGTH
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Indoor Simulation Study on Nutrient Release of Fishponds Sediment 被引量:2
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作者 杜旭彤 谢骏 +2 位作者 王广军 余德光 赵旭斌 《Agricultural Science & Technology》 CAS 2009年第3期127-130,138,共5页
[Objective] The study aimed to research the nutrients release of ponds sediment.[Method] The sediments which from a new pond(A) and an old one (B) these analyses used to carry out indoor experiment under the anaerobic... [Objective] The study aimed to research the nutrients release of ponds sediment.[Method] The sediments which from a new pond(A) and an old one (B) these analyses used to carry out indoor experiment under the anaerobic dark condition for researching on nutrient release. The N(nitrogenous) and P(phosphorous) release were analyzed every two days.[Result] At the prophase, the N release in B was bigger than that in A, while the decline sediment release in A was gentle.[Conclusion] There was no accumulation of organic compound during the breeding time. The NH4-N was the main form of N release; and the P release was correlated with N release, while PO4-P was the main form of P release. 展开更多
关键词 SEDIMENT Nutrient release Indoor simulation study Oxidation reduction potential (ORP)
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Simulation study on factors influencing the entrainment behavior of liquid steel as bubbles pass through the steel/slag interface 被引量:3
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作者 Xiang Li Yan-ping Bao +1 位作者 Min Wang Lu Lin 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS CSCD 2016年第5期511-519,共9页
In this study, a water/silicone oil interface was used to simulate the steel/slag interface in a converter. A high-speed camera was used to record the entrainment process of droplets when air bubbles were passed throu... In this study, a water/silicone oil interface was used to simulate the steel/slag interface in a converter. A high-speed camera was used to record the entrainment process of droplets when air bubbles were passed through the water/silicone oil interface. Motion parameters of the bubbles and droplets were obtained using particle kinematic analysis software, and the entrainment rate of the droplets was calculated. It was found that the entrainment rate decreased from 29.5% to 0 when the viscosity of the silicone oil was increased from 60 mPa.s to 820 mPa.s in the case of bubbles with a 5 mm equivalent diameter passing through the water/silicone oil interface. The results indicate that in- creasing the viscosity of the silicone oil is conducive to reducing the entrainment rate. The entrainment rate increased from 0 to 136.3% in the case of silicone oil with a viscosity of 60 mPa.s when the equivalent diameter of the bubbles was increased from 3 mm to 7 ram. We there- fore conclude that small bubbles are also conductive to reducing the entrainment rate. The force analysis results for the water colmnn indicate that the entrainment rate of droplets is affected by the velocity of the bubble passing through the water/silicone oil interface and that the en- trainment rate decreases with the bubble velocity. 展开更多
关键词 STEELMAKING BUBBLES INTERFACES ENTRAINMENT influencing factors simulation studies
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Study on Numerical Simulation of Mold Filling and Heat Transfer in Die Casting Process 被引量:17
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作者 Liangrong JIA, Shoumei XIONG and Baicheng LIU (Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China) 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2000年第3期269-272,共4页
A 3-D mathematical model considering turbulence phenomena has been established based on a computational fluid dynamics technique, so called 3-D SOLA-VOF (Solution Algorithm-Volume of Fluid), to simulate the fluid flow... A 3-D mathematical model considering turbulence phenomena has been established based on a computational fluid dynamics technique, so called 3-D SOLA-VOF (Solution Algorithm-Volume of Fluid), to simulate the fluid flow of mold filling process of die casting. In addition, the mathematical model for simulating the heat transfer in die casting process has also been established. The computation program has been developed by the authors with the finite difference method (FDM) recently. As verification, the mold filling process of a S-shaped die casting has been simulated and the simulation results coincide with that of the benchmark test. Finally, as a practical application, the gating design of a motorcycle component was modified by the mold filling simulation and the dies design of another motorcycle component was optimized by the heat transfer simulation. All the optimized designs were verified by the production practice. 展开更多
关键词 Study on Numerical simulation of Mold Filling and Heat Transfer in Die Casting Process MOLD simulation
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Effect of Valence Band Tail Width on the Open Circuit Voltage of P3HT:PCBM Bulk Heterojunction Solar Cell:AMPS-1D Simulation Study 被引量:5
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作者 Bushra Mohamed Omer 《Chinese Physics Letters》 SCIE CAS CSCD 2015年第8期216-220,共5页
The effect of the valence band tail width on the open circuit voltage of P3HT:PCBM bulk heterojunction solar cell is investigated by using the AMPS-1D computer program. An effective medium model with exponential vale... The effect of the valence band tail width on the open circuit voltage of P3HT:PCBM bulk heterojunction solar cell is investigated by using the AMPS-1D computer program. An effective medium model with exponential valence and conduction band tail states is used to simulate the photovoltaic cell. The simulation result shows that the open circuit voltage depends Iinearly on the logarithm of the generation rate and the slope depends on the width of the valence band tail. The open circuit voltage decreases with the increasing width of the band tail. The dark and light ideality factors increase with the width of the valence band tail. 展开更多
关键词 Effect of Valence Band Tail Width on the Open Circuit Voltage of P3HT:PCBM Bulk Heterojunction Solar Cell:AMPS-1D simulation Study HT
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Using agent-based simulation to assess diseaseprevention measures during pandemics 被引量:1
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作者 Yunhe Tong Christopher King Yanghui Hu 《Chinese Physics B》 SCIE EI CAS CSCD 2021年第9期643-651,共9页
Despite the growing interest in macroscopic epidemiological models to deal with threats posed by pandemics such as COVID-19,little has been done regarding the assessment of disease spread in day-to-day life,especially... Despite the growing interest in macroscopic epidemiological models to deal with threats posed by pandemics such as COVID-19,little has been done regarding the assessment of disease spread in day-to-day life,especially within buildings such as supermarkets where people must obtain necessities at the risk of exposure to disease.Here,we propose an integrated customer shopping simulator including both shopper movement and choice behavior,using a force-based and discrete choice model,respectively.By a simple extension to the force-based model,we implement the following preventive measures currently taken by supermarkets;social distancing and one-way systems,and different customer habits,assessing them based on the average individual disease exposure and the time taken to complete shopping(shopping efficiency).Results show that maintaining social distance is an effective way to reduce exposure,but at the cost of shopping efficiency.We find that the one-way system is the optimal strategy for reducing exposure while minimizing the impact on shopping efficiency.Customers should also visit supermarkets less frequently,but buy more when they do,if they wish to minimize their exposure.We hope that this work demonstrates the potential of pedestrian dynamics simulations in assessing preventative measures during pandemics,particularly if it is validated using empirical data. 展开更多
关键词 pedestrian dynamics occupant exposure COVID-19 simulation study
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Study and Application of Mold Filling Simulation of Shaped Castings 被引量:5
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作者 Baicheng LIU Wei QIU +1 位作者 Houfa SHEN Zhiqiang GAO (Dept. of Mechanical Engineering, Tsinghua University Beijing 100084, China) 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 1997年第2期107-112,共6页
In this paper, an algorithm for simulating fluid flow and heat transfer for mold filling of shaped castings is presented. The main features of the algorithm include: 1) a simple but practical technique based on VOF me... In this paper, an algorithm for simulating fluid flow and heat transfer for mold filling of shaped castings is presented. The main features of the algorithm include: 1) a simple but practical technique based on VOF method to determine free surface, 2) an explicit scheme of enthalpy to solve the energy equation more efficiently, and 3) an effective treatment to modify the flux deviation due to pressure iteration. In order to verify these methods, well controlled experiments have been repeatedly done with both water analog and gray iron pouring experiments to record the flow patterns and temperature variations. The calculated results are in accordance with the experimental ones. For the applications, the simulated initial temperature distribution right after mold filling was used to analyse subsequent solidification and to predict shrinkage defects. Actual castings were poured and tested in a foundry plant. The reuslts show that the defects predication with considering fluid flow effects is more precise than that without considering the effects. 展开更多
关键词 simulation Study and Application of Mold Filling simulation of Shaped Castings MOLD
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Dynamic Simulation and Valve Structure Optimization of an Electro-Hydraulic Clutch Shift Control System in an Automatic Transmission 被引量:1
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作者 韩笑 刘艳芳 +1 位作者 徐向阳 唐树晗 《Journal of Donghua University(English Edition)》 EI CAS 2015年第5期842-850,共9页
The electro-hydraulic clutch control system controls the transferred torque of gear-shifting clutches in clutch-to-clutch transmissions. A nonlinear dynamic model of an electro-hydraulic clutch shift control system is... The electro-hydraulic clutch control system controls the transferred torque of gear-shifting clutches in clutch-to-clutch transmissions. A nonlinear dynamic model of an electro-hydraulic clutch shift control system is presented. The mechanical and fluid subsystems of all valves are investigated, including their interactions. Model validation of the electro-hydraulic valve system is performed by comparing the simulated and measured pressure curves. The dynamic characteristics of the electro-hydraulic clutch shift control system with different supply pressures and different fluid temperatures are simulated and evaluated. It is found that pipes which are often ignored between the electro-hydraulic valve system and the clutch piston,have strong influence on clutch piston chamber pressures. In order to satisfy the required time and reduce the fluctuation of the clutch piston chamber pressures,the orifices' diameters and valve structure are optimized. 展开更多
关键词 clutch shift control system hydraulic valve dynamic characteristic simulation study
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A Study on Numerical Simulation of Core-Shooting Process 被引量:1
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作者 Junjiao WU, Yi GUI and Wenzhen LI Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China 《Journal of Materials Science & Technology》 SCIE EI CAS CSCD 2001年第6期625-628,共4页
In order to evaluate the main factors influencing the core-shooting process and to optimize the design of core boxes, the fluid-particle (air-sand) model has been built based on the two-phase flow theory. The fluid ph... In order to evaluate the main factors influencing the core-shooting process and to optimize the design of core boxes, the fluid-particle (air-sand) model has been built based on the two-phase flow theory. The fluid phase, air, and the particulate phase, sand granules, have been treated as a continuum. By using this model, it is possible to simulate the flow and compaction behavior of sand particles during the core-shooting process. To benchmark the calculated results, the shooting process has been recorded with a digital high speed camera, and the inlet condition of sand particles has also been achieved by using the camera. The preliminary results have showed that the calculation is in agreement with the testing results. 展开更多
关键词 A Study on Numerical simulation of Core-Shooting Process CORE simulation
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Impact of Temperature Variation on Performance of Carbon Nanotube Field-Effect Transistor-Based on Chaotic Oscillator:A Quantum Simulation Study
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作者 Van Ha Nguyen Hanjung Song 《Chinese Physics Letters》 SCIE CAS CSCD 2015年第3期141-144,共4页
We evaluate the impact of temperature on the output behavior of a carbon nanotube field effect transistor (CNFET) based chaotic generator. The sources cause the variations in both current-voltage characteristics of ... We evaluate the impact of temperature on the output behavior of a carbon nanotube field effect transistor (CNFET) based chaotic generator. The sources cause the variations in both current-voltage characteristics of the CNFET device and an overall chaotic circuit is pointed out. To verify the effect of temperature variation on the output dynamics of the chaotic circuit, a simulation is performed by employing the CNFET compact model of Wong et al. in HSPICE with a temperature range from -100℃ to 100℃. The obtained results with time series, frequency spectra, and bifurcation diagram from the simulation demonstrate that temperature plays a significant role in the output dynamics of the CNFET-based chaotic circuit. Thus, temperature-related issues should be taken into account while designing a high-quality chaotic generator with high stability. 展开更多
关键词 CN Impact of Temperature Variation on Performance of Carbon Nanotube Field-Effect Transistor-Based on Chaotic Oscillator:A Quantum simulation Study HSPICE MOSFET
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Simulation Study on the ITB Formation during LHCD in JT-60U
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作者 崔正英 Osamu Naito +3 位作者 Takeshi Fukudai Hiroshi Shirai Yoshitaka Ikeda Kenkichi Ushigusa 《Plasma Science and Technology》 SCIE EI CAS CSCD 2002年第2期1197-1206,共10页
A transport simulation has been done by using a i.5D time dependent transportcode to reproduce a formation of the ITB on electron temperature Profile during the long pu1seLHCD in JT-60U tokamak. The transport coeffici... A transport simulation has been done by using a i.5D time dependent transportcode to reproduce a formation of the ITB on electron temperature Profile during the long pu1seLHCD in JT-60U tokamak. The transport coefficients were assumed to reduce with a reversedmagnetic shear and the LH driven current profile was evaluated by fitting dynamic change inthe measured current profile. The gradual increase in the central electron temperature could beexplained by the change in the current profile during LHCD in the present simulation model. Theestimated LH-driven current profile by the transport code analysis shows a finite current densityat the plasma center. Analysis of transport simulation suggests some mechanisms for broadeningthe LH-driven current profile at the central region of the plasma. 展开更多
关键词 LHCD simulation Study on the ITB Formation during LHCD in JT-60U ITB
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Simulation Study on the Controllable Dielectrophoresis Parameters of Graphene
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作者 Jian-Long Ji Ya-Li Liu +7 位作者 Yang Ge Sheng-Dong Xie Xi Zhang Sheng-Bo Sang Ao-Qun Jian Qian-Qian Duan Qiang Zhang Wen-Dong Zhang 《Chinese Physics Letters》 SCIE CAS CSCD 2017年第4期71-74,共4页
The method of using dielectrophoresis (DEP) to assemble graphene between micro-electrodes has been proven to be simple and efficient. We present an optimization method for the kinetic formula of graphene DEP, and di... The method of using dielectrophoresis (DEP) to assemble graphene between micro-electrodes has been proven to be simple and efficient. We present an optimization method for the kinetic formula of graphene DEP, and discuss the simulation of the graphene assembly process based on the finite element method. The simulated results illustrate that the accelerated motion of graphene is in agreement with the distribution of the electric field squared gradient. We also conduct research on the controllable parameters of the DEP assembly such as the alternating current (AC) frequency, the shape of micro-electrodes, and the ratio of the gap between electrodes to the characteristic/geometric length of graphene (λ). The simulations based on the Clausius-Mossotti factor reveal that both graphene velocity and direction are influenced by the AC frequency. When graphene is close to the electrodes, the shape of micro-electrodes will exert great influence on the velocity of graphene. Also, λ has a great influence on the velocity of graphene. Generally, the velocity of graphene would be greater when λ is in the range of 0.4 0.6. The study is of a theoretical guiding significance in improving the precision and efficiency of the graphene DEP assembly. 展开更多
关键词 DEP simulation Study on the Controllable Dielectrophoresis Parameters of Graphene
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A simulation study on CO_2 assimilation and crop growth in agroforest ecosystems in the East China Plain
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《Journal of Environmental Sciences》 SCIE EI CAS CSCD 1997年第4期81-89,共9页
AsimulationstudyonCO2asimilationandcropgrowthinagroforestecosystemsintheEastChinaPlainZhouLin,WangHanjieEcoE... AsimulationstudyonCO2asimilationandcropgrowthinagroforestecosystemsintheEastChinaPlainZhouLin,WangHanjieEcoEnvironmentalRese... 展开更多
关键词 A simulation study on CO2 assimilation and crop growth in agroforest ecosystems in the East China Plain CO
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A Simulation Study on Boiler Fault Diagnosis Expert System
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作者 Li Tianduo, Yang Liming,Xu Lidong, Lu BoquanThermal Eng. Dept., Tsinghua University 《Electricity》 1996年第2期44-46,共3页
The boiler is one of the key parts of power station. Monitoring the operation of the boiler automatically, continuously and accurately is very important. In case of malfunctions, an expert system might be helpful to f... The boiler is one of the key parts of power station. Monitoring the operation of the boiler automatically, continuously and accurately is very important. In case of malfunctions, an expert system might be helpful to find the sources of faults, and thereafter will assist the operator to act correctly and to prevent the fault from further development.In this paper, a simulation study of an expert system, which can diagnose the running faults of boiler system, is conducted. Shallow and deep two-layer knowledge base structure is used in this two layers of knowledge base. So. this kind of expert system can overcome the disadvantages of the old types of expert systems, which are only able to deal with experience rules base.A simulator of power boiler is used for the research on fault diagnose expert system. This boiler simulator gives all necessary information for the diagnosis. The knowledge base of expert system is built in hierarchies, so the speed of reasoning may be invreased. After the reasoning the 展开更多
关键词 simulation A simulation Study on Boiler Fault Diagnosis Expert System
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The Effects of Axial-Flow Pump in Supporting of Regional Ischemic Left Ventricle: A Simulation Study
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作者 Bing Zhao and Jing Bai(Department of Electrical Engineering, The School of Life Science and Engineering,Tsinghua University, Beijing 100084, China) 《Chinese Journal of Biomedical Engineering(English Edition)》 1999年第3期46-47,共2页
关键词 simulation A simulation Study The Effects of Axial-Flow Pump in Supporting of Regional Ischemic Left Ventricle FLOW
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Numerical simulation study of Karst groundwater flow in Beisan area
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《Global Geology》 1998年第1期65-66,共2页
关键词 Numerical simulation study of Karst groundwater flow in Beisan area FLOW
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A Study on the Computer Numerical Simulation of Radial Keratotomy by Finite Element Method
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《Chinese Journal of Biomedical Engineering(English Edition)》 1999年第4期120-121,共2页
关键词 simulation A Study on the Computer Numerical simulation of Radial Keratotomy by Finite Element Method
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Optimizing ASReview Simulations:A generic Multiprocessing Solution for“Light-data'and“Heavy-data'Users
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作者 Sergei Romanov Abel Soares Siqueira +3 位作者 Jonathan de Bruin Jelle Teijema Laura Hofstee Rens van de Schoot 《Data Intelligence》 EI 2024年第2期320-343,共24页
Active learning can be used for optimizing and speeding up the screening phase of systematic reviews.Running simulation studies mimicking the screening process can be used to test the performance of different machine-... Active learning can be used for optimizing and speeding up the screening phase of systematic reviews.Running simulation studies mimicking the screening process can be used to test the performance of different machine-learning models or to study the impact of different training data.This paper presents an architecture design withamultiprocessing computational strategyforrunningmanysuch simulation studiesinparallel,using the ASReview Makita workflow generator and Kubernetes software for deployment with cloud technologies.We provide a technical explanation of the proposed cloud architecture and its usage.In addition to that,we conducted 1140 simulations investigating the computational time using various numbers of CPUs and RAM settings.Our analysis demonstrates the degree to which simulations can be accelerated with multiprocessing computing usage.The parallel computation strategy and the architecture design that was developed in the present paper can contribute to future research with more optimal simulation time and,at the same time,ensure the safe completion of the needed processes. 展开更多
关键词 Active learning Systematic review simulation study MULTIPROCESSING Cloud architecture
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Suggestion of global model for carob batch fermentation to produce bioethanol
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作者 Bilel Hadrich Nabil Kechaou 《Journal of Chemistry and Chemical Engineering》 2009年第8期44-49,63,共7页
Modelling of carob batch fermentation is established basing on mass transfer balances. The modelling treats the reaction kinetics of substrate (S), the micro-organisms (X) and the ethanol (E). Nine models are ta... Modelling of carob batch fermentation is established basing on mass transfer balances. The modelling treats the reaction kinetics of substrate (S), the micro-organisms (X) and the ethanol (E). Nine models are taken from the literature to describe specific organism growth rate and specific ethanol development rate. These models treat all types of fermentation. The Phisalapbong et al. model and the Ghose and Tyagi model show the best fit of the experimental data. This affirms that the batch fermentation of carob is conducted with substrate and/or ethanol inhibition. Some simulations and relationships (X = f(S), E = f(S)) are obtained from the Phisalaphong et al. model. Those simulations show a lot of important and useful results of carob batch fermentation process. 展开更多
关键词 kinetics and mechanisms of reactions mathematical modelling modelling and simulation studies
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