To study the influence of thickness on the magnetic properties of ReBCO(Re = Y, Gd, Sm, Nd, etc.) bulk superconductors, a single domain gadolinium barium copper oxide(GdBCO) bulk superconductor fabricated by the Re + ...To study the influence of thickness on the magnetic properties of ReBCO(Re = Y, Gd, Sm, Nd, etc.) bulk superconductors, a single domain gadolinium barium copper oxide(GdBCO) bulk superconductor fabricated by the Re + 011 top seeded infiltration growth(Re + 011 TSIG) method was continuously sliced along the bottom to obtain samples of different thickness. The levitation force and attractive force of these samples were tested at 77 K in the zero-field-cooled(ZFC)state. It is found that as the sample thickness decreases, the levitation force decreases gradually whereas the attractive force increases. This is related to the varied ability to resist the penetration of magnetic field occasioned by varying sample thickness, which are deeply revealed by combining with the characteristics of the non-ideal type-II superconductor. Further,the levitation force exhibits a trend of slow initial change followed by rapid change, which may be attributed to the growth of the sample. Measurement of the trapped field shows that a similar distribution of trapped field at the top and bottom surfaces can be achieved by removing some materials from the bottom of the bulk. These results provide a reference for meeting the actual requirements of ReBCO bulks of different thicknesses and greatly contribute to practical designs and applications.展开更多
Many physical experiments have shown that the domain switching in a ferroelectric material is a complicated evolution process of the domain wall with the variation of stress and electric field. According to this mecha...Many physical experiments have shown that the domain switching in a ferroelectric material is a complicated evolution process of the domain wall with the variation of stress and electric field. According to this mechanism, the volume fraction of the domain switching is introduced in the constitutive law of ferroelectric ceramic and used to study the nonlinear constitutive behavior of ferroelectric body in this paper. The principle of stationary total energy is put forward in which the basic unknown quantities are the displacement ui, electric displacement Di and volume fraction pI of the domain switching for the variant I. Mechanical field equation and a new domain switching criterion are obtained from the principle of stationary total energy. The domain switching criterion proposed in this paper is an expansion and development of the energy criterion. On the basis of the domain switching criterion, a set of linear algebraic equations for the volume fraction PI of domain switching is obtained, in which the coefficients of the linear algebraic equations only contain the unknown strain and electric fields. Then a single domain mechanical model is proposed in this paper. The poled ferroelectric specimen is considered as a transversely isotropic single domain. By using the partial experimental results, the hardening relation between the driving force of domain switching and the volume fraction of domain switching can be calibrated. Then the electromechanical response can be calculated on the basis of the calibrated hardening relation. The results involve the electric butterfly shaped curves of axial strain versus axial electric field, the hysteresis loops of electric displacement versus electric filed and the evo- lution process of the domain switching in the ferroelectric specimens under uniaxial coupled stress and electric field loading. The present theoretic prediction agrees reasonably with the experimental results given by Lynch.展开更多
Ebola virus(EBOV) belongs to the Filoviridae family and causes severe illnesses such as hemorrhagic fever with a high mortality rate up to 90%. Now two antibody drugs termed Inmazeb and Ebanga have been approved for t...Ebola virus(EBOV) belongs to the Filoviridae family and causes severe illnesses such as hemorrhagic fever with a high mortality rate up to 90%. Now two antibody drugs termed Inmazeb and Ebanga have been approved for treating EBOV infection. However, clinical studies have demonstrated that the mortality rate of the patients who received these two antibody drugs remains above 30%. Therefore, novel therapeutics with better efficacy is still desired. The isolated human IgG1 constant domain 2(CH2 domain) has been proposed as a scaffold for the development of C-based single domain antibodies(C-sd Abs) as therapeutic candidates against viral infections and other diseases. Here, we screened and identified a novel C-sd Ab termed M24 that targets EBOV glycoprotein(GP) from a C-sd Ab phage display library. M24 neutralizes the pseudotype EBOV with IC;of 0.8 nmol/L(12 ng/mL) and has modest neutralizing activity against authentic EBOV.Epitope determination, including molecular docking and site mutation analysis, discloses that M24 binds to the internal fusion loop(IFL) within GP2, a transmembrane subunit of GP. Interestingly, we found that the binding of M24 to GP at pH5.5 has dramatically decreased compared to the binding at pH 7.5, which may lead to weak efficacy in the neutralization of authentic EBOV. Since no sd Ab against EBOV infection has been reported to date, our results not only give a proof of concept that sd Abs could be utilized for the development of potential therapeutic candidates against EBOV infection, but also provide useful information for the discovery and improvement of anti-EBOV agents.展开更多
The magnetic anisotropy of Fe 25 Ni 75 nanocrystallites in the range of 10～20 nm was measured by the law of approach to saturation. The samples were prepared by mechanical alloying process, and the average ...The magnetic anisotropy of Fe 25 Ni 75 nanocrystallites in the range of 10～20 nm was measured by the law of approach to saturation. The samples were prepared by mechanical alloying process, and the average crystal size was determined by X ray diffraction. The effective magnetic anisotropy of these fine particles is found in an order of 10 6 erg/cm 3 that is much greater than that of normal crystal size of particles. The dependence of magnetic anisotropy on the particle size was studied. It has been demonstrated that the strain anisotropy occupies the most of the total magnetic anisotropy, and the internal strain is a critical factor for their magnetic properties.展开更多
An improved algorithm of Delaunay triangulation is proposed by expanding the scope from a convex polygon to an arbitrary polygon area in which holes can be contained in the subdivision procedure. The data structure of...An improved algorithm of Delaunay triangulation is proposed by expanding the scope from a convex polygon to an arbitrary polygon area in which holes can be contained in the subdivision procedure. The data structure of generated triangles and the exuviationslike method play a key role, and a single connectivity domain (SCD) without holes is constructed as the initial part of the algorithm. Meanwhile, some examples show that the method can be applied to the triangulation of the trimmed NURBS surface. The result of surface tessellation can be used in many applications such as NC machining, finite element analysis, rendering and mechanism interference detection.展开更多
Awide spectrum of Androgen insensitivity syndrome （AIS） occur due to mutations in the androgen receptor（AR）. The clinical presentation of AIS ranges from a typically male phenotype with decreased body hair and/ or...Awide spectrum of Androgen insensitivity syndrome （AIS） occur due to mutations in the androgen receptor（AR）. The clinical presentation of AIS ranges from a typically male phenotype with decreased body hair and/ or oligospermia to a typically female phenotype with primary amenorrhea and without pubic and axillary hair;展开更多
The fabrication of near-net-shaped objects of RE123 superconductors by 'infiltration processing' is discussed. Near-net-shape processing involves the infiltration of preshaped porous green bodies of either 211...The fabrication of near-net-shaped objects of RE123 superconductors by 'infiltration processing' is discussed. Near-net-shape processing involves the infiltration of preshaped porous green bodies of either 211 or yttria phases by liquids containing barium cuprates and copper oxides followed by a controlled peritectic solidification. The process yields poly- and also single-crystalline superconducting objects with a shrinkage of less than half of one percent of the green bodies. The preservation of the initial structure of the green bodies results in fabrication of RE 123 in a wide variety of dimensions and complex shapes. The demonstrated products include bulk components like cylinders, single domain thick films on a variety of substrates, freestanding fabrics and open porous superconducting foams. This paper presents a comprehensive description of the infiltration processing technique and the resulting microstructures of the superconducting bodies. The advantages of this technique and practical applications of the processed superconducting structures are highlighted.展开更多
基金supported by the National Natural Science Foundation of China (Grant No. 52072229)the Key-grant Project of the Ministry of Education of China (Grant No. 311033)+1 种基金the Fundamental Research Funds for the Central Universities (Grant No. GK201706001)the Teaching Reform and Innovation Project of Higher Education in Shanxi Province, China (Grant No. J2021719)。
文摘To study the influence of thickness on the magnetic properties of ReBCO(Re = Y, Gd, Sm, Nd, etc.) bulk superconductors, a single domain gadolinium barium copper oxide(GdBCO) bulk superconductor fabricated by the Re + 011 top seeded infiltration growth(Re + 011 TSIG) method was continuously sliced along the bottom to obtain samples of different thickness. The levitation force and attractive force of these samples were tested at 77 K in the zero-field-cooled(ZFC)state. It is found that as the sample thickness decreases, the levitation force decreases gradually whereas the attractive force increases. This is related to the varied ability to resist the penetration of magnetic field occasioned by varying sample thickness, which are deeply revealed by combining with the characteristics of the non-ideal type-II superconductor. Further,the levitation force exhibits a trend of slow initial change followed by rapid change, which may be attributed to the growth of the sample. Measurement of the trapped field shows that a similar distribution of trapped field at the top and bottom surfaces can be achieved by removing some materials from the bottom of the bulk. These results provide a reference for meeting the actual requirements of ReBCO bulks of different thicknesses and greatly contribute to practical designs and applications.
基金The project supported by the National Natural Science Foundation of China(10572138)
文摘Many physical experiments have shown that the domain switching in a ferroelectric material is a complicated evolution process of the domain wall with the variation of stress and electric field. According to this mechanism, the volume fraction of the domain switching is introduced in the constitutive law of ferroelectric ceramic and used to study the nonlinear constitutive behavior of ferroelectric body in this paper. The principle of stationary total energy is put forward in which the basic unknown quantities are the displacement ui, electric displacement Di and volume fraction pI of the domain switching for the variant I. Mechanical field equation and a new domain switching criterion are obtained from the principle of stationary total energy. The domain switching criterion proposed in this paper is an expansion and development of the energy criterion. On the basis of the domain switching criterion, a set of linear algebraic equations for the volume fraction PI of domain switching is obtained, in which the coefficients of the linear algebraic equations only contain the unknown strain and electric fields. Then a single domain mechanical model is proposed in this paper. The poled ferroelectric specimen is considered as a transversely isotropic single domain. By using the partial experimental results, the hardening relation between the driving force of domain switching and the volume fraction of domain switching can be calibrated. Then the electromechanical response can be calculated on the basis of the calibrated hardening relation. The results involve the electric butterfly shaped curves of axial strain versus axial electric field, the hysteresis loops of electric displacement versus electric filed and the evo- lution process of the domain switching in the ferroelectric specimens under uniaxial coupled stress and electric field loading. The present theoretic prediction agrees reasonably with the experimental results given by Lynch.
基金This work was jointly supported by the Advanced Customer Cultivation Project of Wuhan National Biosafety Laboratory,Chinese Academy of Sciences(2021ACCP-MS01,2019ACCP-ZD03)the Natural Science Foundation of Hubei Province of China(2019CFA076)the National Natural Science Foundation of China(31870926)。
文摘Ebola virus(EBOV) belongs to the Filoviridae family and causes severe illnesses such as hemorrhagic fever with a high mortality rate up to 90%. Now two antibody drugs termed Inmazeb and Ebanga have been approved for treating EBOV infection. However, clinical studies have demonstrated that the mortality rate of the patients who received these two antibody drugs remains above 30%. Therefore, novel therapeutics with better efficacy is still desired. The isolated human IgG1 constant domain 2(CH2 domain) has been proposed as a scaffold for the development of C-based single domain antibodies(C-sd Abs) as therapeutic candidates against viral infections and other diseases. Here, we screened and identified a novel C-sd Ab termed M24 that targets EBOV glycoprotein(GP) from a C-sd Ab phage display library. M24 neutralizes the pseudotype EBOV with IC;of 0.8 nmol/L(12 ng/mL) and has modest neutralizing activity against authentic EBOV.Epitope determination, including molecular docking and site mutation analysis, discloses that M24 binds to the internal fusion loop(IFL) within GP2, a transmembrane subunit of GP. Interestingly, we found that the binding of M24 to GP at pH5.5 has dramatically decreased compared to the binding at pH 7.5, which may lead to weak efficacy in the neutralization of authentic EBOV. Since no sd Ab against EBOV infection has been reported to date, our results not only give a proof of concept that sd Abs could be utilized for the development of potential therapeutic candidates against EBOV infection, but also provide useful information for the discovery and improvement of anti-EBOV agents.
文摘The magnetic anisotropy of Fe 25 Ni 75 nanocrystallites in the range of 10～20 nm was measured by the law of approach to saturation. The samples were prepared by mechanical alloying process, and the average crystal size was determined by X ray diffraction. The effective magnetic anisotropy of these fine particles is found in an order of 10 6 erg/cm 3 that is much greater than that of normal crystal size of particles. The dependence of magnetic anisotropy on the particle size was studied. It has been demonstrated that the strain anisotropy occupies the most of the total magnetic anisotropy, and the internal strain is a critical factor for their magnetic properties.
文摘An improved algorithm of Delaunay triangulation is proposed by expanding the scope from a convex polygon to an arbitrary polygon area in which holes can be contained in the subdivision procedure. The data structure of generated triangles and the exuviationslike method play a key role, and a single connectivity domain (SCD) without holes is constructed as the initial part of the algorithm. Meanwhile, some examples show that the method can be applied to the triangulation of the trimmed NURBS surface. The result of surface tessellation can be used in many applications such as NC machining, finite element analysis, rendering and mechanism interference detection.
文摘Awide spectrum of Androgen insensitivity syndrome （AIS） occur due to mutations in the androgen receptor（AR）. The clinical presentation of AIS ranges from a typically male phenotype with decreased body hair and/ or oligospermia to a typically female phenotype with primary amenorrhea and without pubic and axillary hair;
基金German Federal Ministry of Higher Education and Research(BMBF)(No.13N1571/l)
文摘The fabrication of near-net-shaped objects of RE123 superconductors by 'infiltration processing' is discussed. Near-net-shape processing involves the infiltration of preshaped porous green bodies of either 211 or yttria phases by liquids containing barium cuprates and copper oxides followed by a controlled peritectic solidification. The process yields poly- and also single-crystalline superconducting objects with a shrinkage of less than half of one percent of the green bodies. The preservation of the initial structure of the green bodies results in fabrication of RE 123 in a wide variety of dimensions and complex shapes. The demonstrated products include bulk components like cylinders, single domain thick films on a variety of substrates, freestanding fabrics and open porous superconducting foams. This paper presents a comprehensive description of the infiltration processing technique and the resulting microstructures of the superconducting bodies. The advantages of this technique and practical applications of the processed superconducting structures are highlighted.
