With the growth of capacity of high voltage direct current(HVDC) transmission lines,the ratings of thyristor valves,which are one of the most critical equipments,are getting higher and higher.Verification of performan...With the growth of capacity of high voltage direct current(HVDC) transmission lines,the ratings of thyristor valves,which are one of the most critical equipments,are getting higher and higher.Verification of performance of thyristor valves particularly designed for HVDC project plays an important role in the handover of products between the manufacturer and the client.Conventional test facilities based on philosophy of direct test cannot meet the requirements for modern thyristor valves.New test facilities with high ratings are necessarily built based on philosophy of synthetic test.Over the conventional direct test circuit,the later is an economical and feasible solution with less financial investment and higher test capability.However,the equivalency between the synthetic test and the direct test should be analyzed technically in order to make sure that the condition of verification test in a synthetic test circuit should satisfy the actual operation condition of thyristor valves existing in a real HVDC project,just as in a direct test circuit.Equivalency analysis is focused in this paper,covering the scope of thyristor valves' steady state,and transient state.On the basis of the results achieved,a synthetic test circuit of 6 500 A/50 kV for operational tests of thyristor valves used for up to UHVDC project has newly been set up and already put into service in Xi'an High Voltage Apparatus Research Institute Co.,Ltd.(XIHARI),China.Some of the results have been adopted also by a new national standard of China.展开更多
Dear Editor:Kosta et al.;first ever reported the development of biologic electronic components viz resistance R,capacitance C,diode D and transistor T using human tissues and human skin.In our early study;,we have dem...Dear Editor:Kosta et al.;first ever reported the development of biologic electronic components viz resistance R,capacitance C,diode D and transistor T using human tissues and human skin.In our early study;,we have demonstrated the feasibility of liquid medium（synthetic blood plasma）to develop bio-transistor,bio-resistor,and bio-capacitor and combined them to form an amplifier using the metallic harness(the interconnecting展开更多
Thyristor valve is one of the key equipments for ultra high voltage direct current(UHVDC) power transmission projects.Before being installed on site,they need to be tested in a laboratory in order to verify their oper...Thyristor valve is one of the key equipments for ultra high voltage direct current(UHVDC) power transmission projects.Before being installed on site,they need to be tested in a laboratory in order to verify their operational performance to satisfy the technical specification of project related.Test facilities for operational tests of thyristor valves are supposed to enable to undertake more severe electrical stresses than those being applied in the thyristor valves under test(test objects).On the other hand,the stresses applied into the test objects are neither higher nor lower than specified by the specification,because inappropriate stresses applied would result in incorrect evaluation of performance on the test objects,more seriously,would cuase the damage of test objects with expensive cost losing.Generally,the process of operational tests is complicated and performed in a complex synthetic test circuit(hereafter as STC),where there are a lot of sensors used for measuring,monitoring and protection on line to ensure that the test circuit functions in good condition.Therefore,the measuring systems embedded play a core role in STC,acting like "eyes".Based on the first project of building up a STC in China,experience of planning measuring systems is summarized so as to be referenced by related engineers.展开更多
Background:Microfluidic systems have advantages such as a high throughput,small reaction volume,and precise control of the cellular position and environment.These advantages have allowed microfluidics to be widely use...Background:Microfluidic systems have advantages such as a high throughput,small reaction volume,and precise control of the cellular position and environment.These advantages have allowed microfluidics to be widely used in several fields of synthetic biology in recent years.Results'.In this article,we reviewed the microfluidic-based methods for synthetic biology from two aspects:the construction of synthetic gene circuits and the analysis of synthetic gene systems.We used some examples to illuminate the progresses and challenges in the steps of synthetic gene circuits construction and approaches of gene expression analysis with microfluidic systems.Conclusion:Comparing to traditional methods,microfluidic tools promise great advantages in the synthetic genetic circuit building and analysis process.Moreover,new microfluidic systems together with the mathematical modeling of synthetic circuits or consortiums are desirable to perform complex genetic circuit construction and understand the natural gene regulation in cells and population interactions better.展开更多
Background： Recently, optogenetics based on genetically encoded photosensitive proteins has emerged as an innovative technology platform to revolutionize manipulation of cellular behavior through fight stimulation. I...Background： Recently, optogenetics based on genetically encoded photosensitive proteins has emerged as an innovative technology platform to revolutionize manipulation of cellular behavior through fight stimulation. It has enabled user defined control of various cellular behaviors with spatiotemporal precision and minimal invasiveness, creating unprecedented opportunities for biomedical applications. Results： This article reviews current advances in optogenetic networks designed for the treatment of human diseases. We highlight the advantages of these optogenetic networks, as well as emerging questions and future perspectives. Conclusions： Various optogenetic systems have been engineered to control biological processes at all levels using light and applied for numerous diseases, such as metabolic disorders, cancer, and immune diseases. Continued development of optogenetic modules will be necessary to precisely control of gene expression magnitude towards clinical medical practice in the context of real-world problems.展开更多
Airborne diseases including SARS,bird flu,and the ongoing Coronavirus Disease 2019(COVID-19)have stimulated the demand for developing novel bioassay methods competent for early-stage diagnosis and large-scale screenin...Airborne diseases including SARS,bird flu,and the ongoing Coronavirus Disease 2019(COVID-19)have stimulated the demand for developing novel bioassay methods competent for early-stage diagnosis and large-scale screening.Here,we briefly summarize the state-of-the-art methods for the detection of infectious pathogens and discuss key challenges.We highlight the trend for next-generation technologies benefiting from multidisciplinary advances in microfabrication,nanotechnology and synthetic biology,which allow sensitive,rapid yet inexpensive pathogen assays with portable intelligent device.展开更多
基金Project Supported by National Development and Reform Commission(No.[2006]2709)
文摘With the growth of capacity of high voltage direct current(HVDC) transmission lines,the ratings of thyristor valves,which are one of the most critical equipments,are getting higher and higher.Verification of performance of thyristor valves particularly designed for HVDC project plays an important role in the handover of products between the manufacturer and the client.Conventional test facilities based on philosophy of direct test cannot meet the requirements for modern thyristor valves.New test facilities with high ratings are necessarily built based on philosophy of synthetic test.Over the conventional direct test circuit,the later is an economical and feasible solution with less financial investment and higher test capability.However,the equivalency between the synthetic test and the direct test should be analyzed technically in order to make sure that the condition of verification test in a synthetic test circuit should satisfy the actual operation condition of thyristor valves existing in a real HVDC project,just as in a direct test circuit.Equivalency analysis is focused in this paper,covering the scope of thyristor valves' steady state,and transient state.On the basis of the results achieved,a synthetic test circuit of 6 500 A/50 kV for operational tests of thyristor valves used for up to UHVDC project has newly been set up and already put into service in Xi'an High Voltage Apparatus Research Institute Co.,Ltd.(XIHARI),China.Some of the results have been adopted also by a new national standard of China.
文摘Dear Editor:Kosta et al.;first ever reported the development of biologic electronic components viz resistance R,capacitance C,diode D and transistor T using human tissues and human skin.In our early study;,we have demonstrated the feasibility of liquid medium（synthetic blood plasma）to develop bio-transistor,bio-resistor,and bio-capacitor and combined them to form an amplifier using the metallic harness(the interconnecting
基金Project Supported by National Development and Reform Commission(No.[2006]2709)
文摘Thyristor valve is one of the key equipments for ultra high voltage direct current(UHVDC) power transmission projects.Before being installed on site,they need to be tested in a laboratory in order to verify their operational performance to satisfy the technical specification of project related.Test facilities for operational tests of thyristor valves are supposed to enable to undertake more severe electrical stresses than those being applied in the thyristor valves under test(test objects).On the other hand,the stresses applied into the test objects are neither higher nor lower than specified by the specification,because inappropriate stresses applied would result in incorrect evaluation of performance on the test objects,more seriously,would cuase the damage of test objects with expensive cost losing.Generally,the process of operational tests is complicated and performed in a complex synthetic test circuit(hereafter as STC),where there are a lot of sensors used for measuring,monitoring and protection on line to ensure that the test circuit functions in good condition.Therefore,the measuring systems embedded play a core role in STC,acting like "eyes".Based on the first project of building up a STC in China,experience of planning measuring systems is summarized so as to be referenced by related engineers.
基金This study was supported the National Key Research and Development Project(SQ2018YFA090070-03 and 2020YFA0906900)the National Natural Science Foundation of China(Nos.11974002 and 11674010).
文摘Background:Microfluidic systems have advantages such as a high throughput,small reaction volume,and precise control of the cellular position and environment.These advantages have allowed microfluidics to be widely used in several fields of synthetic biology in recent years.Results'.In this article,we reviewed the microfluidic-based methods for synthetic biology from two aspects:the construction of synthetic gene circuits and the analysis of synthetic gene systems.We used some examples to illuminate the progresses and challenges in the steps of synthetic gene circuits construction and approaches of gene expression analysis with microfluidic systems.Conclusion:Comparing to traditional methods,microfluidic tools promise great advantages in the synthetic genetic circuit building and analysis process.Moreover,new microfluidic systems together with the mathematical modeling of synthetic circuits or consortiums are desirable to perform complex genetic circuit construction and understand the natural gene regulation in cells and population interactions better.
文摘Background： Recently, optogenetics based on genetically encoded photosensitive proteins has emerged as an innovative technology platform to revolutionize manipulation of cellular behavior through fight stimulation. It has enabled user defined control of various cellular behaviors with spatiotemporal precision and minimal invasiveness, creating unprecedented opportunities for biomedical applications. Results： This article reviews current advances in optogenetic networks designed for the treatment of human diseases. We highlight the advantages of these optogenetic networks, as well as emerging questions and future perspectives. Conclusions： Various optogenetic systems have been engineered to control biological processes at all levels using light and applied for numerous diseases, such as metabolic disorders, cancer, and immune diseases. Continued development of optogenetic modules will be necessary to precisely control of gene expression magnitude towards clinical medical practice in the context of real-world problems.
基金This work was financially supported by the National Natural Science Foundation of China(21991134,91953106)Science Foundation of the Shanghai Municipal Science and Technology Commission(19JC1410300,21dz2210100)。
文摘Airborne diseases including SARS,bird flu,and the ongoing Coronavirus Disease 2019(COVID-19)have stimulated the demand for developing novel bioassay methods competent for early-stage diagnosis and large-scale screening.Here,we briefly summarize the state-of-the-art methods for the detection of infectious pathogens and discuss key challenges.We highlight the trend for next-generation technologies benefiting from multidisciplinary advances in microfabrication,nanotechnology and synthetic biology,which allow sensitive,rapid yet inexpensive pathogen assays with portable intelligent device.
