The traditional teaching methods of one-way cultivation of students can no longer meet the requirements of talent cultivation at this stage.The issue of how to promote students from passive acceptance to the independe...The traditional teaching methods of one-way cultivation of students can no longer meet the requirements of talent cultivation at this stage.The issue of how to promote students from passive acceptance to the independent cognitive understanding stage(i.e.deep learning)has become the focus of geography teaching.Therefore,under the guidance of deep learning theory,this paper takes the“landforms”knowledge unit of the Humanistic Education Edition as an example,improves the classroom teaching means through the unit teaching mode,reconstructs the“landforms”teaching unit,and explores the specific teaching of high school geography unit based on deep learning.This study provides a good example and guidelines for high school geography teaching and learning.展开更多
Small-molecule drugs are essential for maintaining human health. The objective of this study is to identify a molecule that can inhibit the Factor Xa protein and be easily procured. An optimization-based de novo drug ...Small-molecule drugs are essential for maintaining human health. The objective of this study is to identify a molecule that can inhibit the Factor Xa protein and be easily procured. An optimization-based de novo drug design framework, Drug CAMD, that integrates a deep learning model with a mixed-integer nonlinear programming model is used for designing drug candidates. Within this framework, a virtual chemical library is specifically tailored to inhibit Factor Xa. To further filter and narrow down the lead compounds from the designed compounds, comprehensive approaches involving molecular docking,binding pose metadynamics(BPMD), binding free energy calculations, and enzyme activity inhibition analysis are utilized. To maximize efficiency in terms of time and resources, molecules for in vitro activity testing are initially selected from commercially available portions of customized virtual chemical libraries. In vitro studies assessing inhibitor activities have confirmed that the compound EN300-331859shows potential Factor Xa inhibition, with an IC_(50)value of 34.57 μmol·L^(-1). Through in silico molecular docking and BPMD, the most plausible binding pose for the EN300-331859-Factor Xa complex are identified. The estimated binding free energy values correlate well with the results obtained from biological assays. Consequently, EN300-331859 is identified as a novel and effective sub-micromolar inhibitor of Factor Xa.展开更多
基于现代会议管理的需求,设计和实现一种C/S和B/S混合部署的会议管理系统。包括会议管理服务中心和若干个会议现场,会议管理服务中心包括数据服务器、应用服务器、Web服务器、通信网关和出口路由器;会议现场包括若干个便携式电脑、RFID(...基于现代会议管理的需求,设计和实现一种C/S和B/S混合部署的会议管理系统。包括会议管理服务中心和若干个会议现场,会议管理服务中心包括数据服务器、应用服务器、Web服务器、通信网关和出口路由器;会议现场包括若干个便携式电脑、RFID(Radio Frequency Identification)读卡器、二维码阅读器、信息显示发布设备、现场WLAN设备及用户终端。使用RIA(Rich Internet Application)技术优化了B/S界面,应用RFID对会议过程中的细节进行监控,借助SAAS(Software as a Service)模式实现会议管理按需配置和快速部署。该系统显著提高了会议管理效率。展开更多
Deep shale gas reservoirs being developed by SINOPEC are characterized by significant buried depths, high rock strengths, high temperatures and pressures, multiple layers, low ROPs, prolonged drilling time and prohibi...Deep shale gas reservoirs being developed by SINOPEC are characterized by significant buried depths, high rock strengths, high temperatures and pressures, multiple layers, low ROPs, prolonged drilling time and prohibitoryhigh costs. All of these factors may negatively affect the economic and effective development of shale gas. Under such circumstances, existing drilling techniques for deep shale gas around the world have been reviewed to highlight technical challenges in deep shale gas drilling in China. With consideration to the previous drilling operations of SINOPEC for deep shale gas, technical solutions for deep shale gas drilling have been proposed with regard to the optimization of casing programs, enhanced drilling, trajectory control, high-density oil-based drilling fluid, cementation for deep shale gas development and other aspects. Some of these research findings have been deployed with great successes in Pingqiao, Jiangdong Block in the 2nd Phase of Fuling Project, Dingshan Block and other blocks with deep shale gas development. Among them, Well JY-74-2HF has had a drilling time of only 54.25d, whereas Well JY-187-2HF has a TVD up to 4024.14m. Relevant research results may provide valuable guidance and references for the optimization of drilling programs andthe enhancement ofdrilling ef^ciency for deep shale gas development.展开更多
文摘The traditional teaching methods of one-way cultivation of students can no longer meet the requirements of talent cultivation at this stage.The issue of how to promote students from passive acceptance to the independent cognitive understanding stage(i.e.deep learning)has become the focus of geography teaching.Therefore,under the guidance of deep learning theory,this paper takes the“landforms”knowledge unit of the Humanistic Education Edition as an example,improves the classroom teaching means through the unit teaching mode,reconstructs the“landforms”teaching unit,and explores the specific teaching of high school geography unit based on deep learning.This study provides a good example and guidelines for high school geography teaching and learning.
基金financial supports of the National Natural Science Foundation of China (22078041, 22278053,22208042)Dalian High-level Talents Innovation Support Program (2023RQ059)“the Fundamental Research Funds for the Central Universities (DUT20JC41, DUT22YG218)”。
文摘Small-molecule drugs are essential for maintaining human health. The objective of this study is to identify a molecule that can inhibit the Factor Xa protein and be easily procured. An optimization-based de novo drug design framework, Drug CAMD, that integrates a deep learning model with a mixed-integer nonlinear programming model is used for designing drug candidates. Within this framework, a virtual chemical library is specifically tailored to inhibit Factor Xa. To further filter and narrow down the lead compounds from the designed compounds, comprehensive approaches involving molecular docking,binding pose metadynamics(BPMD), binding free energy calculations, and enzyme activity inhibition analysis are utilized. To maximize efficiency in terms of time and resources, molecules for in vitro activity testing are initially selected from commercially available portions of customized virtual chemical libraries. In vitro studies assessing inhibitor activities have confirmed that the compound EN300-331859shows potential Factor Xa inhibition, with an IC_(50)value of 34.57 μmol·L^(-1). Through in silico molecular docking and BPMD, the most plausible binding pose for the EN300-331859-Factor Xa complex are identified. The estimated binding free energy values correlate well with the results obtained from biological assays. Consequently, EN300-331859 is identified as a novel and effective sub-micromolar inhibitor of Factor Xa.
文摘基于现代会议管理的需求,设计和实现一种C/S和B/S混合部署的会议管理系统。包括会议管理服务中心和若干个会议现场,会议管理服务中心包括数据服务器、应用服务器、Web服务器、通信网关和出口路由器;会议现场包括若干个便携式电脑、RFID(Radio Frequency Identification)读卡器、二维码阅读器、信息显示发布设备、现场WLAN设备及用户终端。使用RIA(Rich Internet Application)技术优化了B/S界面,应用RFID对会议过程中的细节进行监控,借助SAAS(Software as a Service)模式实现会议管理按需配置和快速部署。该系统显著提高了会议管理效率。
文摘Deep shale gas reservoirs being developed by SINOPEC are characterized by significant buried depths, high rock strengths, high temperatures and pressures, multiple layers, low ROPs, prolonged drilling time and prohibitoryhigh costs. All of these factors may negatively affect the economic and effective development of shale gas. Under such circumstances, existing drilling techniques for deep shale gas around the world have been reviewed to highlight technical challenges in deep shale gas drilling in China. With consideration to the previous drilling operations of SINOPEC for deep shale gas, technical solutions for deep shale gas drilling have been proposed with regard to the optimization of casing programs, enhanced drilling, trajectory control, high-density oil-based drilling fluid, cementation for deep shale gas development and other aspects. Some of these research findings have been deployed with great successes in Pingqiao, Jiangdong Block in the 2nd Phase of Fuling Project, Dingshan Block and other blocks with deep shale gas development. Among them, Well JY-74-2HF has had a drilling time of only 54.25d, whereas Well JY-187-2HF has a TVD up to 4024.14m. Relevant research results may provide valuable guidance and references for the optimization of drilling programs andthe enhancement ofdrilling ef^ciency for deep shale gas development.
