The complex and volatile international landscape has significantly impacted global grain supply security. This study uses a complex network analysis model to examine the evolution and trends of the global major grain ...The complex and volatile international landscape has significantly impacted global grain supply security. This study uses a complex network analysis model to examine the evolution and trends of the global major grain trade from 1990 to 2020, focusing on network topology, centrality ranking, and community structure. There are three major findings. First, the global major grain trade network has expanded in scale, with a growing emphasis on diversification and balance. During the study period, the United States, Canada, China, and Brazil were the core nodes of the network. Grain-exporting countries were mainly situated in Asia, the Americas, and Europe, and importing countries in Asia, Africa, and Europe. Second, a significant increase in the number of high centrality countries with high export capacity occurred, benefiting from natural advantages such as fertile land and favorable climates. Third, the main global grain trade network is divided into four communities, with the Americas-Europe community being the largest and most widespread. The formation of the community pattern was influenced by geographic proximity, driven by the core exporting countries. Therefore, the world needs to enhance the existing trade model, promote the multi-polarization of the grain trade network, and establish a global vision for the future community. Countries and regions should participate actively in global grain trade security governance and institutional reform, expand trade links with other countries, and optimize import and export policies to reduce trade risks.展开更多
“The Government Work Report noted that‘development of the New International Land-Sea Trade Corridor will be accelerated’,”stated Wei Zhaohui,member of the Standing Committee of the 14th National Committee of the C...“The Government Work Report noted that‘development of the New International Land-Sea Trade Corridor will be accelerated’,”stated Wei Zhaohui,member of the Standing Committee of the 14th National Committee of the Chinese People’s Political Consultative Conference(CPPCC)and director-general of the Guangxi International Expo Affairs Bureau,in an interview after the Second Session of the 14th National People’s Congress on March 5.展开更多
From the perspective of group standards, the dynamics of the cosmetic industry in the past few years were briefly reviewed and analyzed, including the number of group standards published, types of group standards, gro...From the perspective of group standards, the dynamics of the cosmetic industry in the past few years were briefly reviewed and analyzed, including the number of group standards published, types of group standards, groups, and geographical distribution of the groups. The large number of participating groups and the wide range of geographical distribution indicated that group standards could play a positive role in the sustained and positive development of cosmetic industry. The future development of cosmetic industry was also prospected。展开更多
Technical barriers to trade,as a non-tariff barrier,have an increasing impact on the international market.As a major province in toy exports,Zhejiang Province’s toy export trade is therefore greatly hindered.This art...Technical barriers to trade,as a non-tariff barrier,have an increasing impact on the international market.As a major province in toy exports,Zhejiang Province’s toy export trade is therefore greatly hindered.This article aims to explore the impact of technical trade barriers on toy exports in Zhejiang Province and analyze countermeasures.Through literature review and some empirical analysis,it is found that technical trade barriers have greatly promoted the development of Zhejiang’s toy industry;however,they have also subjected it to impacts and pressures such as cost and technology.In response to the impact of technical trade barriers on toy exports,this article proposes corresponding countermeasures to avoid such barriers:firstly,establish a quality management system that complies with export product regulations to ensure that the products produced can meet international requirements and standards;secondly,reduce dependence on overseas markets;then enhance one’s own technology,and strengthen product innovation,in order to enhance the international competitiveness of the product and oneself;in addition,we should also explore diversified markets and expand the sales channels and coverage of our products.展开更多
Background:Agarwood,primarily derived from the Aquilaria and Gyrinops genera,holds significant economic importance.However,there is a lack of comprehensive investigations providing guidance to importing nations regard...Background:Agarwood,primarily derived from the Aquilaria and Gyrinops genera,holds significant economic importance.However,there is a lack of comprehensive investigations providing guidance to importing nations regarding cultivation quantities and expected yields of Agarwood from distinct species.This study aims to address this gap by exploring the historical context and trade evolution of Agarwood,highlighting its global importance,and the challenges associated with securing accurate species information.Method:On-site visits to Agarwood cultivation sites were conducted to gain a nuanced understanding of Aquilaria species and their cultivation requirements.Additionally,a thorough analysis of global export and import data for Agarwood products over the last decade was undertaken.Results:China Mainland emerged as the leading exporter of Agarwood,averaging an annual export value of USD 1 million.India’s substantial exports challenge the prevailing notion of limited Agarwood production within its borders.Hong Kong and Singapore are pivotal distribution hubs,while Hong Kong and Taipei feature prominently as import destinations.Our analysis uncovers anomalies in the representation of Agarwood producers from 2001 to 2008,suggesting potential misclassification of Aquilaria Agarwood as Gyrinops in global export information.These findings underscore the urgency of investigating classification and reporting practices in the Agarwood trade.Furthermore,A.filaria emerges as a notable source,while A.malaccensis is decline in prominence.Conclusion:This study provides crucial insights for policymakers,stakeholders,and industry players seeking to make informed decisions in the Agarwood trade landscape.The results highlight the need for accurate species identification,classification,and reporting practices to ensure sustainable cultivation and trade of Agarwood.展开更多
Shandong is a significant province for foreign trade in China;however,it still faces shortcomings in the development of its service trade,as outlined below.Firstly,the scale of service trade is limited.Shandong’s ser...Shandong is a significant province for foreign trade in China;however,it still faces shortcomings in the development of its service trade,as outlined below.Firstly,the scale of service trade is limited.Shandong’s service trade volume ranked sixth in China in 2022,lagging considerably behind Shanghai,Guangdong,Beijing,Zhejiang,and Jiangsu.Secondly,the proportion of service trade in Shandong compared to the overall national services trade volume falls below the national average,with the per capita scale even lower than the national average.Thirdly,Shandong’s service trade accounts for less than 10% of the province’s foreign trade,which is 3 percentage points below the national average.The insufficient development of Shandong’s service trade is mainly attributed to the weak performance of its own service industry and the limited scale of attracting foreign services investment.Accelerating the development of producer services in Shandong,promoting the intelligent upgrading of consumer services,and continuously promoting reform and opening up in the service sector will be conducive to achieving high-quality development of services trade in Shandong.展开更多
In order to explore and foster innovation in international exchange and cooperation,this study focuses on the background of the construction of the Hainan Free Trade Port.It delves into the current development status,...In order to explore and foster innovation in international exchange and cooperation,this study focuses on the background of the construction of the Hainan Free Trade Port.It delves into the current development status,characteristic demands,and potential challenges of its international exchange and cooperation mechanisms.Through a comprehensive analysis of relevant cases,survey questionnaires,and literature,this study aims to provide feasible innovative models and recommendations to promote the sustained development of the Hainan Free Trade Port in the field of international exchange and cooperation,injecting new vitality into China’s economic globalization.This exploration contributes to a deeper understanding of the development of free trade ports and provides insights and references for other countries and regions.展开更多
Society is currently transitioning from the era of informatization and digitization to the era of intelligence.Advanced technologies such as artificial intelligence,the Internet of Things,and big data are permeating e...Society is currently transitioning from the era of informatization and digitization to the era of intelligence.Advanced technologies such as artificial intelligence,the Internet of Things,and big data are permeating every aspect of production and life.This penetration presents a rare opportunity for the development of digital trade and catalyzes innovation in traditional trade patterns.This paper first analyzes the inevitability of digital trade development in Northeast Asia.Secondly,it delves into the challenges faced by digital trade development and explores in-depth the promotion strategy for digital trade’s impact on the economic development of the Northeast Asia region,providing insights from various perspectives for reference.展开更多
As science and technology continue to develop,power equipment has become an indispensable part of industrial production and daily life.Whether it is the precise automation machinery utilized on production lines or the...As science and technology continue to develop,power equipment has become an indispensable part of industrial production and daily life.Whether it is the precise automation machinery utilized on production lines or the convenient electrical appliances found in households,their functionality relies heavily on electrical technology.Nonetheless,without stringent safety and performance assurances,these devices could potentially endanger lives and property.Thus,this paper explores the development strategy for establishing a standardized system within the electrical testing service industry,aiming to ensure safety and reliability.展开更多
Both farmers and traders benefit from trade networking, which is crucial for the local economy. Therefore, it is crucial to understand how these networks operate, and how they can be managed more effectively. Througho...Both farmers and traders benefit from trade networking, which is crucial for the local economy. Therefore, it is crucial to understand how these networks operate, and how they can be managed more effectively. Throughout this study, we examine the economic networks formed between farmers and traders through the trade of food products. These networks are analyzed from the perspective of their structure and the factors that influence their development. Using data from 18 farmers and 15 traders, we applied exponential random graph models. The results of our study showed that connectivity, Popularity Spread, activity spread, good transportation systems, and high yields all affected the development of networks. Therefore, farmers’ productivity and high market demand can contribute to local food-crop trade. The network was not affected by reciprocity, open markets, proximity to locations, or trade experience of actors. Policy makers should consider these five factors when formulating policies for local food-crop trade. Additionally, local actors should be encouraged to use these factors to improve their network development. However, it is important to note that these factors alone cannot guarantee success. Policy makers and actors must also consider other factors such as legal frameworks, economic policies, and resource availability. Our approach can be used in future research to determine how traders and farmers can enhance productivity and profit in West Africa. This study addresses a research gap by examining factors influencing local food trade in a developing country.展开更多
Monitoring of host cell proteins(HCPs)during the manufacturing of monoclonal antibodies(mAb)has become a critical requirement to provide effective and safe drug products.Enzyme-linked immunosorbent assays are still th...Monitoring of host cell proteins(HCPs)during the manufacturing of monoclonal antibodies(mAb)has become a critical requirement to provide effective and safe drug products.Enzyme-linked immunosorbent assays are still the gold standard methods for the quantification of protein impurities.However,this technique has several limitations and does,among others,not enable the precise identification of proteins.In this context,mass spectrometry(MS)became an alternative and orthogonal method that delivers qualitative and quantitative information on all identified HCPs.However,in order to be routinely implemented in biopharmaceutical companies,liquid chromatography-MS based methods still need to be standardized to provide highest sensitivity and robust and accurate quantification.Here,we present a promising MS-based analytical workflow coupling the use of an innovative quantification standard,the HCP Profiler solution,with a spectral library-based data-independent acquisition(DIA)method and strict data validation criteria.The performances of the HCP Profiler solution were compared to more conventional standard protein spikes and the DIA approach was benchmarked against a classical datadependent acquisition on a series of samples produced at various stages of the manufacturing process.While we also explored spectral library-free DIA interpretation,the spectral library-based approach still showed highest accuracy and reproducibility(coefficients of variation<10%)with a sensitivity down to the sub-ng/mg mAb level.Thus,this workflow is today mature to be used as a robust and straightforward method to support mAb manufacturing process developments and drug products quality control.展开更多
Financing of the African Integrated High-Speed Railway Network (AIHSRN) through Standard Gauge Railway (SGR) Projects is very expensive. As a result, most of the African countries seek financial supports from the Inte...Financing of the African Integrated High-Speed Railway Network (AIHSRN) through Standard Gauge Railway (SGR) Projects is very expensive. As a result, most of the African countries seek financial supports from the International Financial Institutions (IFIs). However, conditions provided by the IFIs through the Performance Standards (PS) of the International Financial Corporation (IFC) increase cost of the projects and thus, it becomes a burden to most of the African countries. This study aimed to explore the causes of IFC-PS through the SGR Projects that escalate costs and how to address them. The Tanzania SGR Lot 1 Project that covered 205 km from Dar es Salaam to Morogoro was selected as a case study. The methods used for data collection involved literature review, focus group discussions and interviews. The results and findings show a gap between the IFC-PS and the National Laws and Regulations that escalates costs of the projects if funds from the IFIs were to be secured. To bridge the gap, it is recommended that the African countries should engage into negotiations with the IFIs to agree to waive IFC-PS conditions that escalate costs provided they are adequately covered in the national laws and regulations;engagement of locally established national and regional financial institutions;and the responsible government institutions in the African countries should sit together for assessment and review of the IFC-PS against the national laws and regulations.展开更多
Entering 2023,direct investment from overseas enterprises and institutions has been shifting towards the service industry,which is now one of the most popular sectors for foreign investment.At a recent seminar themed...Entering 2023,direct investment from overseas enterprises and institutions has been shifting towards the service industry,which is now one of the most popular sectors for foreign investment.At a recent seminar themed“Benchmarking International Standards and Promoting Trade Facilitation”,Mr.Yu Bo,Managing Partner of integrated business consulting of PwC China,said in an interview that:“Expanding high-level opening-up of the service industry requires more active exploration into aligning with new international economic and trade rules,which can be done by early and pilot implementation in some areas.”展开更多
The foreign trade industry in China had a good start in general this year,thanks to the rapid growth in cross-border e-commerce.The 2022 China Cross Border E-Commerce Market Data Report was released at the cross-borde...The foreign trade industry in China had a good start in general this year,thanks to the rapid growth in cross-border e-commerce.The 2022 China Cross Border E-Commerce Market Data Report was released at the cross-border e-commerce roundtable meeting held on March 30th this year,indicating that cross-border e-commerce made a contribution of 37.32%to China’s total import and export trade value in goods(RMB 42.07 trillion)in 2022.展开更多
At a recent regular press conference of the CCPIT,the CCPIT Research Institute released the EU Business Environment Report 2022/2023.The report shows that in 2022,China-EU relations have remained stable,with a g...At a recent regular press conference of the CCPIT,the CCPIT Research Institute released the EU Business Environment Report 2022/2023.The report shows that in 2022,China-EU relations have remained stable,with a good momentum behind bilateral trade and investment cooperation.The bilateral cooperation has huge potential and brings about many opportunities.展开更多
2022 was extraordinary.The COVID-19 pandemic together with downward consumption,put the macro economy under greater pressure.However,against complex and severe situations at home and abroad,China remained the world’s...2022 was extraordinary.The COVID-19 pandemic together with downward consumption,put the macro economy under greater pressure.However,against complex and severe situations at home and abroad,China remained the world’s second largest economy in 2022,and the total value of imports and exports exceeded RMB 40 trillion for the first time,making a new record and meaning China has been the leading goods trading country across the world for six consecutive years.All these figures demonstrated the strong resilience of China’s foreign trade.In the same year,the 20th CPC National Congress was held successfully,injecting more certainty for the future development of China.展开更多
On August 30,the CCPIT held the monthly press conference.Sun Xiao,spokesperson of the CCPIT,made response to topics like overseas expansion of companies,further optimization of business environment and the first China...On August 30,the CCPIT held the monthly press conference.Sun Xiao,spokesperson of the CCPIT,made response to topics like overseas expansion of companies,further optimization of business environment and the first China International Supply Chain Expo.The enthusiasm for participating and hosting exhibitions overseas remains undiminished According to Sun Xiao,in July 2023,the CCPIT and its sub-branches issued a total of 546,200 certificates of origin,ATA documents and commer-cial certificates,an increase of 12.82%compared to the previous year.展开更多
As the first national exhibition held in China for Northeast Asian participants this year,the 14th China-Northeast Asia Expo kicked off on August 23rd as scheduled.Themed“Joint Development of Northeast Asia,in Cooper...As the first national exhibition held in China for Northeast Asian participants this year,the 14th China-Northeast Asia Expo kicked off on August 23rd as scheduled.Themed“Joint Development of Northeast Asia,in Cooperation for the Future”,the Expo organized forums and exhibitions,and built new platforms to set up new prospects.展开更多
The present study aims to analyze the growing Sino-Brazilian trade relationship and how China has contributed to the commodity price boom in the recent period.Throughout the article,it was possible to identify that th...The present study aims to analyze the growing Sino-Brazilian trade relationship and how China has contributed to the commodity price boom in the recent period.Throughout the article,it was possible to identify that the export and import agenda between countries differs in terms of number of products and technological intensity,so that imported products are capital intensive,while exported products are predominantly commodities.The text is divided into two main sections,firstly addressing the literature review on the commodities boom and highlighting the“China effect”.The second section analyzes trade between the countries,so that the trade relationship has followed an increasing trajectory since 2003.As of 2009,China has become Brazil’s main trading partner,surpassing historical partners such as the United States and Argentina.展开更多
Starting from the effects of diseases and pests on tea quality,tea industry and export trade,the status quo and control of tea diseases and pests,assurance and traceability of tea quality safety,tea industry and expor...Starting from the effects of diseases and pests on tea quality,tea industry and export trade,the status quo and control of tea diseases and pests,assurance and traceability of tea quality safety,tea industry and export trade development are analyzed in detail,and green prevention and control measures against tea diseases and pests are put forward combined with the status quo of tea in China.展开更多
基金funded by the National Natural Science Foundation of China(42271313)the Chinese Academy of Agricultural Sciences Innovation Project(CAAS-ASTIP2021-AII)the Central Public-interest Scientific Institution Basal Research Fund,China(JBYW-AII-2022-06,JBYWAII-2022-40)。
文摘The complex and volatile international landscape has significantly impacted global grain supply security. This study uses a complex network analysis model to examine the evolution and trends of the global major grain trade from 1990 to 2020, focusing on network topology, centrality ranking, and community structure. There are three major findings. First, the global major grain trade network has expanded in scale, with a growing emphasis on diversification and balance. During the study period, the United States, Canada, China, and Brazil were the core nodes of the network. Grain-exporting countries were mainly situated in Asia, the Americas, and Europe, and importing countries in Asia, Africa, and Europe. Second, a significant increase in the number of high centrality countries with high export capacity occurred, benefiting from natural advantages such as fertile land and favorable climates. Third, the main global grain trade network is divided into four communities, with the Americas-Europe community being the largest and most widespread. The formation of the community pattern was influenced by geographic proximity, driven by the core exporting countries. Therefore, the world needs to enhance the existing trade model, promote the multi-polarization of the grain trade network, and establish a global vision for the future community. Countries and regions should participate actively in global grain trade security governance and institutional reform, expand trade links with other countries, and optimize import and export policies to reduce trade risks.
文摘“The Government Work Report noted that‘development of the New International Land-Sea Trade Corridor will be accelerated’,”stated Wei Zhaohui,member of the Standing Committee of the 14th National Committee of the Chinese People’s Political Consultative Conference(CPPCC)and director-general of the Guangxi International Expo Affairs Bureau,in an interview after the Second Session of the 14th National People’s Congress on March 5.
文摘From the perspective of group standards, the dynamics of the cosmetic industry in the past few years were briefly reviewed and analyzed, including the number of group standards published, types of group standards, groups, and geographical distribution of the groups. The large number of participating groups and the wide range of geographical distribution indicated that group standards could play a positive role in the sustained and positive development of cosmetic industry. The future development of cosmetic industry was also prospected。
基金Research on the Development of Cross Border E-commerce and High Quality Economic Development in Guangdong Province(Project Number:2022HSXS068).
文摘Technical barriers to trade,as a non-tariff barrier,have an increasing impact on the international market.As a major province in toy exports,Zhejiang Province’s toy export trade is therefore greatly hindered.This article aims to explore the impact of technical trade barriers on toy exports in Zhejiang Province and analyze countermeasures.Through literature review and some empirical analysis,it is found that technical trade barriers have greatly promoted the development of Zhejiang’s toy industry;however,they have also subjected it to impacts and pressures such as cost and technology.In response to the impact of technical trade barriers on toy exports,this article proposes corresponding countermeasures to avoid such barriers:firstly,establish a quality management system that complies with export product regulations to ensure that the products produced can meet international requirements and standards;secondly,reduce dependence on overseas markets;then enhance one’s own technology,and strengthen product innovation,in order to enhance the international competitiveness of the product and oneself;in addition,we should also explore diversified markets and expand the sales channels and coverage of our products.
基金Jiangxi Province Double Thousand Talent-Leader of Natural Science Project(jxsq2023101038)Jiangxi Province Urgently Overseas Talent Project(2022BCJ25027)+1 种基金The Key Research Projects in Jiangxi Province(20223BBH8007&20232BBG70014)Innovation Team Project in Key Areas of Jiujiang City Base and Talent Plan(S2022TDJS029).
文摘Background:Agarwood,primarily derived from the Aquilaria and Gyrinops genera,holds significant economic importance.However,there is a lack of comprehensive investigations providing guidance to importing nations regarding cultivation quantities and expected yields of Agarwood from distinct species.This study aims to address this gap by exploring the historical context and trade evolution of Agarwood,highlighting its global importance,and the challenges associated with securing accurate species information.Method:On-site visits to Agarwood cultivation sites were conducted to gain a nuanced understanding of Aquilaria species and their cultivation requirements.Additionally,a thorough analysis of global export and import data for Agarwood products over the last decade was undertaken.Results:China Mainland emerged as the leading exporter of Agarwood,averaging an annual export value of USD 1 million.India’s substantial exports challenge the prevailing notion of limited Agarwood production within its borders.Hong Kong and Singapore are pivotal distribution hubs,while Hong Kong and Taipei feature prominently as import destinations.Our analysis uncovers anomalies in the representation of Agarwood producers from 2001 to 2008,suggesting potential misclassification of Aquilaria Agarwood as Gyrinops in global export information.These findings underscore the urgency of investigating classification and reporting practices in the Agarwood trade.Furthermore,A.filaria emerges as a notable source,while A.malaccensis is decline in prominence.Conclusion:This study provides crucial insights for policymakers,stakeholders,and industry players seeking to make informed decisions in the Agarwood trade landscape.The results highlight the need for accurate species identification,classification,and reporting practices to ensure sustainable cultivation and trade of Agarwood.
文摘Shandong is a significant province for foreign trade in China;however,it still faces shortcomings in the development of its service trade,as outlined below.Firstly,the scale of service trade is limited.Shandong’s service trade volume ranked sixth in China in 2022,lagging considerably behind Shanghai,Guangdong,Beijing,Zhejiang,and Jiangsu.Secondly,the proportion of service trade in Shandong compared to the overall national services trade volume falls below the national average,with the per capita scale even lower than the national average.Thirdly,Shandong’s service trade accounts for less than 10% of the province’s foreign trade,which is 3 percentage points below the national average.The insufficient development of Shandong’s service trade is mainly attributed to the weak performance of its own service industry and the limited scale of attracting foreign services investment.Accelerating the development of producer services in Shandong,promoting the intelligent upgrading of consumer services,and continuously promoting reform and opening up in the service sector will be conducive to achieving high-quality development of services trade in Shandong.
文摘In order to explore and foster innovation in international exchange and cooperation,this study focuses on the background of the construction of the Hainan Free Trade Port.It delves into the current development status,characteristic demands,and potential challenges of its international exchange and cooperation mechanisms.Through a comprehensive analysis of relevant cases,survey questionnaires,and literature,this study aims to provide feasible innovative models and recommendations to promote the sustained development of the Hainan Free Trade Port in the field of international exchange and cooperation,injecting new vitality into China’s economic globalization.This exploration contributes to a deeper understanding of the development of free trade ports and provides insights and references for other countries and regions.
文摘Society is currently transitioning from the era of informatization and digitization to the era of intelligence.Advanced technologies such as artificial intelligence,the Internet of Things,and big data are permeating every aspect of production and life.This penetration presents a rare opportunity for the development of digital trade and catalyzes innovation in traditional trade patterns.This paper first analyzes the inevitability of digital trade development in Northeast Asia.Secondly,it delves into the challenges faced by digital trade development and explores in-depth the promotion strategy for digital trade’s impact on the economic development of the Northeast Asia region,providing insights from various perspectives for reference.
基金Tianshui City Science and Technology Support Plan Project:2023-FZJHK-2813。
文摘As science and technology continue to develop,power equipment has become an indispensable part of industrial production and daily life.Whether it is the precise automation machinery utilized on production lines or the convenient electrical appliances found in households,their functionality relies heavily on electrical technology.Nonetheless,without stringent safety and performance assurances,these devices could potentially endanger lives and property.Thus,this paper explores the development strategy for establishing a standardized system within the electrical testing service industry,aiming to ensure safety and reliability.
文摘Both farmers and traders benefit from trade networking, which is crucial for the local economy. Therefore, it is crucial to understand how these networks operate, and how they can be managed more effectively. Throughout this study, we examine the economic networks formed between farmers and traders through the trade of food products. These networks are analyzed from the perspective of their structure and the factors that influence their development. Using data from 18 farmers and 15 traders, we applied exponential random graph models. The results of our study showed that connectivity, Popularity Spread, activity spread, good transportation systems, and high yields all affected the development of networks. Therefore, farmers’ productivity and high market demand can contribute to local food-crop trade. The network was not affected by reciprocity, open markets, proximity to locations, or trade experience of actors. Policy makers should consider these five factors when formulating policies for local food-crop trade. Additionally, local actors should be encouraged to use these factors to improve their network development. However, it is important to note that these factors alone cannot guarantee success. Policy makers and actors must also consider other factors such as legal frameworks, economic policies, and resource availability. Our approach can be used in future research to determine how traders and farmers can enhance productivity and profit in West Africa. This study addresses a research gap by examining factors influencing local food trade in a developing country.
基金supported by the“Association Nationale de la Recherche et de la Technologie”and UCB Pharma S.A.(Belgium and France)via the CIFRE fellowship of Steve Hessmannsupported by the“Agence Nationale de la Recherche”via the French Proteomic Infrastructure ProFI FR2048(ANR-10-INBS-08-03).
文摘Monitoring of host cell proteins(HCPs)during the manufacturing of monoclonal antibodies(mAb)has become a critical requirement to provide effective and safe drug products.Enzyme-linked immunosorbent assays are still the gold standard methods for the quantification of protein impurities.However,this technique has several limitations and does,among others,not enable the precise identification of proteins.In this context,mass spectrometry(MS)became an alternative and orthogonal method that delivers qualitative and quantitative information on all identified HCPs.However,in order to be routinely implemented in biopharmaceutical companies,liquid chromatography-MS based methods still need to be standardized to provide highest sensitivity and robust and accurate quantification.Here,we present a promising MS-based analytical workflow coupling the use of an innovative quantification standard,the HCP Profiler solution,with a spectral library-based data-independent acquisition(DIA)method and strict data validation criteria.The performances of the HCP Profiler solution were compared to more conventional standard protein spikes and the DIA approach was benchmarked against a classical datadependent acquisition on a series of samples produced at various stages of the manufacturing process.While we also explored spectral library-free DIA interpretation,the spectral library-based approach still showed highest accuracy and reproducibility(coefficients of variation<10%)with a sensitivity down to the sub-ng/mg mAb level.Thus,this workflow is today mature to be used as a robust and straightforward method to support mAb manufacturing process developments and drug products quality control.
文摘Financing of the African Integrated High-Speed Railway Network (AIHSRN) through Standard Gauge Railway (SGR) Projects is very expensive. As a result, most of the African countries seek financial supports from the International Financial Institutions (IFIs). However, conditions provided by the IFIs through the Performance Standards (PS) of the International Financial Corporation (IFC) increase cost of the projects and thus, it becomes a burden to most of the African countries. This study aimed to explore the causes of IFC-PS through the SGR Projects that escalate costs and how to address them. The Tanzania SGR Lot 1 Project that covered 205 km from Dar es Salaam to Morogoro was selected as a case study. The methods used for data collection involved literature review, focus group discussions and interviews. The results and findings show a gap between the IFC-PS and the National Laws and Regulations that escalates costs of the projects if funds from the IFIs were to be secured. To bridge the gap, it is recommended that the African countries should engage into negotiations with the IFIs to agree to waive IFC-PS conditions that escalate costs provided they are adequately covered in the national laws and regulations;engagement of locally established national and regional financial institutions;and the responsible government institutions in the African countries should sit together for assessment and review of the IFC-PS against the national laws and regulations.
文摘Entering 2023,direct investment from overseas enterprises and institutions has been shifting towards the service industry,which is now one of the most popular sectors for foreign investment.At a recent seminar themed“Benchmarking International Standards and Promoting Trade Facilitation”,Mr.Yu Bo,Managing Partner of integrated business consulting of PwC China,said in an interview that:“Expanding high-level opening-up of the service industry requires more active exploration into aligning with new international economic and trade rules,which can be done by early and pilot implementation in some areas.”
文摘The foreign trade industry in China had a good start in general this year,thanks to the rapid growth in cross-border e-commerce.The 2022 China Cross Border E-Commerce Market Data Report was released at the cross-border e-commerce roundtable meeting held on March 30th this year,indicating that cross-border e-commerce made a contribution of 37.32%to China’s total import and export trade value in goods(RMB 42.07 trillion)in 2022.
文摘At a recent regular press conference of the CCPIT,the CCPIT Research Institute released the EU Business Environment Report 2022/2023.The report shows that in 2022,China-EU relations have remained stable,with a good momentum behind bilateral trade and investment cooperation.The bilateral cooperation has huge potential and brings about many opportunities.
文摘2022 was extraordinary.The COVID-19 pandemic together with downward consumption,put the macro economy under greater pressure.However,against complex and severe situations at home and abroad,China remained the world’s second largest economy in 2022,and the total value of imports and exports exceeded RMB 40 trillion for the first time,making a new record and meaning China has been the leading goods trading country across the world for six consecutive years.All these figures demonstrated the strong resilience of China’s foreign trade.In the same year,the 20th CPC National Congress was held successfully,injecting more certainty for the future development of China.
文摘On August 30,the CCPIT held the monthly press conference.Sun Xiao,spokesperson of the CCPIT,made response to topics like overseas expansion of companies,further optimization of business environment and the first China International Supply Chain Expo.The enthusiasm for participating and hosting exhibitions overseas remains undiminished According to Sun Xiao,in July 2023,the CCPIT and its sub-branches issued a total of 546,200 certificates of origin,ATA documents and commer-cial certificates,an increase of 12.82%compared to the previous year.
文摘As the first national exhibition held in China for Northeast Asian participants this year,the 14th China-Northeast Asia Expo kicked off on August 23rd as scheduled.Themed“Joint Development of Northeast Asia,in Cooperation for the Future”,the Expo organized forums and exhibitions,and built new platforms to set up new prospects.
文摘The present study aims to analyze the growing Sino-Brazilian trade relationship and how China has contributed to the commodity price boom in the recent period.Throughout the article,it was possible to identify that the export and import agenda between countries differs in terms of number of products and technological intensity,so that imported products are capital intensive,while exported products are predominantly commodities.The text is divided into two main sections,firstly addressing the literature review on the commodities boom and highlighting the“China effect”.The second section analyzes trade between the countries,so that the trade relationship has followed an increasing trajectory since 2003.As of 2009,China has become Brazil’s main trading partner,surpassing historical partners such as the United States and Argentina.
基金Supported by Humanities and Sociology Research Project for Colleges and Universities of Guizhou Province(2022ZC016).
文摘Starting from the effects of diseases and pests on tea quality,tea industry and export trade,the status quo and control of tea diseases and pests,assurance and traceability of tea quality safety,tea industry and export trade development are analyzed in detail,and green prevention and control measures against tea diseases and pests are put forward combined with the status quo of tea in China.
