BACKGROUND Intracranial and extracranial artery stenosis is associated with cerebral infarction.Vascular calcification and atherosclerosis are the main causes of stenosis and major risk factors for cardiovascular and ...BACKGROUND Intracranial and extracranial artery stenosis is associated with cerebral infarction.Vascular calcification and atherosclerosis are the main causes of stenosis and major risk factors for cardiovascular and cerebrovascular events in patients with type 2 diabetes mellitus(T2DM).Bone turnover biomarkers(BTMs)are associated with vascular calcification,atherosclerosis,glucose,and lipid metabolism.AIM To investigate the association of circulating BTM levels with severe intracranial and extracranial artery stenosis in patients with T2DM.METHODS For this cross-sectional study including 257 T2DM patients,levels of the BTMs serum osteocalcin(OC),C-terminal cross-linked telopeptide of type I collagen(CTX),and procollagen type I N-peptide were measured by electrical chemiluminescent immunoassay,and artery stenosis was assessed by color Doppler and transcranial Doppler.Patients were grouped according to the existence and location(intracranial vs.extracranial)of artery stenosis.Correlations between BTM levels,previous stroke,stenosis location,and glucose and lipid metabolism were analyzed.RESULTS T2DM patients with severe artery stenosis had a higher frequency of previous stroke and levels of all three tested BTMs(all P<0.05)than patients without.Some differences in OC and CTX levels were observed according to the location of artery stenosis.Significant associations were also observed between BTM levels and some glucose and lipid homeostasis parameters.On multivariate logistic regression analysis,all BTMs were significant predictors of artery stenosis in T2DM patients with and without adjustment for confounding factors(all P<0.001),and receiver operating characteristic curve analysis demonstrated the ability of BTM levels to predict artery stenosis in T2DM patients.CONCLUSION BTM levels were found to be independent risk factors for severe intracranial and extracranial artery stenosis and were differentially associated with glucose and lipid metabolism in patients with T2DM.Therefore,BTMs may be promising biomarkers and potential therapeutic targets for artery stenosis.展开更多
背景与目的肺癌易发生骨转移,I型胶原羧基端肽β特殊序列(β isomer of C-terminal telopeptide of type I collagen,β-CTX)和骨源性碱性磷酸酶(bone-specific alkaline phosphates,BAP)在骨质代谢中是重要的生化标记物,本研究旨在探...背景与目的肺癌易发生骨转移,I型胶原羧基端肽β特殊序列(β isomer of C-terminal telopeptide of type I collagen,β-CTX)和骨源性碱性磷酸酶(bone-specific alkaline phosphates,BAP)在骨质代谢中是重要的生化标记物,本研究旨在探讨骨代谢生化指标和肺癌骨转移进展程度的相关性,有助于早期判断是否有肺癌骨转移的发生。方法天津市人民医院2009年7月-2012年7月共收治92例肺癌并发生骨转移患者,全部病例其原发灶均经细胞学检查证实,骨转移灶的数目及类型经ECT结合X线片、CT证实,采用ELISA方法检测血β-CTX、BAP的浓度水平。结果收集的92例肺癌伴骨转移的患者中,转移灶<3处为58例,≥3处为34例;溶骨型68例,成骨型9例,混合型15例。血β-CTX、BAP水平在不同的骨转移数目组间差异有统计学意义(P<0.05),β-CTX在肺癌溶骨型骨转移患者中具有较高的敏感性。结论骨代谢生化指标β-CTX、BAP对肺癌骨转移具有辅助诊断意义,是判断转移进展程度的良好指标。展开更多
AIM:To investigate the postprandial response of bone turnover markers in patients with Crohn’s disease(CD).METHODS:Fifty nine patients with CD aged 38±14years,and 45 healthy individuals matched for age and body ...AIM:To investigate the postprandial response of bone turnover markers in patients with Crohn’s disease(CD).METHODS:Fifty nine patients with CD aged 38±14years,and 45 healthy individuals matched for age and body mass index were included in the study.All participants underwent an oral glucose tolerance test(OGTT)after an overnight fast and serum levels of the bone resorption marker C-terminal crosslinking telopeptide of type?Ⅰ?collagen(CTX-Ⅰ)and the bone formation marker procollagen type?Ⅰ?N propeptide were measured.Activity of the disease was assessed by calculation of the Crohn’s disease activity index(CDAI).RESULTS:Serum CTX-I was significantly higher in patients compared to controls(CTX-I:453±21 pg/mL vs 365±25 pg/mL,P=0.008),and values were significantly correlated with the activity of the disease(r=0.435,P=0.001).Results from OGTT-induced suppression of CTX-I showed two different trends.Patients with more active disease(assessed as CDAI>150)had a more excessive suppression of CTX-I compared to controls(55%vs 43%P<0.001),while patients on remission(assessed as CDAI<150)demonstrated an attenuated CTX-I suppression(30%vs 43%P<0.001).In line with this,CTX-I suppression after oral glucose load was significantly correlated with the activity of the disease(r=0.913,P<0.001).CONCLUSION:The physiological skeletal response of postprandial suppression of bone resorption is maintained in patients with CD and is strongly dependent to the activity of the disease.展开更多
目的探讨高剂量维生素D补充剂治疗前、后骨质疏松症患者骨代谢标志物水平变化及意义。方法骨质疏松症患者100例,随机分为对照组和维生素D组各50例,对照组口服钙尔奇D 600mg/d;维生素D组在对照组基础上口服维生素D滴剂,1滴/d;2组均连续治...目的探讨高剂量维生素D补充剂治疗前、后骨质疏松症患者骨代谢标志物水平变化及意义。方法骨质疏松症患者100例,随机分为对照组和维生素D组各50例,对照组口服钙尔奇D 600mg/d;维生素D组在对照组基础上口服维生素D滴剂,1滴/d;2组均连续治疗6个月。分别于治疗前,治疗3、6个月时检测2组L_(2-4)、股骨颈及大转子骨密度(bone mineral density,BMD),采用电化学发光法检测血清Ⅰ型胶原羧基端肽β特殊序列(βisomer of C-terminal telopeptide of typeⅠcollagen,β-CTX)和Ⅰ型前胶原氨基端肽(procollagenⅠN-terminal peptide,PⅠNP)水平,并进行比较。结果维生素D组、对照组治疗前BMD在L_(2-4)[(0.683±0.006)、(0.681±0.007)g/cm^2]、股骨颈[(0.559±0.009)、(0.555±0.021)g/cm^2]、大转子[(0.421±0.011)、(0.418±0.011)g/cm^2]比较差异均无统计学意义(P>0.05);治疗6个月时维生素D组BMD在L_(2-4)、肢骨颈、大转子[(0.784±0.172)、(0.679±0.007)、(0.507±0.091)g/cm^2],对照组BMD在L_(2-4)、肢骨颈、大转子[(0.701±0.080)、(0.611±0.163)、(0.457±0.079)g/cm^2]均高于治疗前,且维生素D组高于对照组(P<0.05);2组治疗3个月时L_(2-4)、股骨颈、大转子BMD与治疗前比较差异均无统计学意义(P>0.05);维生素D组治疗前血清β-CTX[(0.74±0.05)μg/L]、PⅠNP[(42.10±3.50)μg/L]与对照组[(0.76±0.12)、(42.40±3.60)μg/L]比较差异无统计学意义(P>0.05);维生素D组及对照组治疗3个月β-CTX[(0.57±0.11)、(0.63±0.14)μg/L]、PⅠNP[(30.20±6.50)、(36.90±10.30)μg/L],治疗6个月β-CTX[(0.33±0.12)、(0.54±0.11)μg/L]、PⅠNP[(24.50±0.90)、(29.60±2.40)μg/L]均低于治疗前(P<0.05),且维生素D组低于对照组(P<0.05)。结论骨质疏松症患者应用高剂量维生素D补充剂治疗可增加BMD,降低血清PⅠNP、β-CTX水平,有助于延缓骨吸收,减少骨量丢失。展开更多
基金Supported by Beijing Municipal Hospital Management Center“Cultivation Plan”,No.PX2022032.
文摘BACKGROUND Intracranial and extracranial artery stenosis is associated with cerebral infarction.Vascular calcification and atherosclerosis are the main causes of stenosis and major risk factors for cardiovascular and cerebrovascular events in patients with type 2 diabetes mellitus(T2DM).Bone turnover biomarkers(BTMs)are associated with vascular calcification,atherosclerosis,glucose,and lipid metabolism.AIM To investigate the association of circulating BTM levels with severe intracranial and extracranial artery stenosis in patients with T2DM.METHODS For this cross-sectional study including 257 T2DM patients,levels of the BTMs serum osteocalcin(OC),C-terminal cross-linked telopeptide of type I collagen(CTX),and procollagen type I N-peptide were measured by electrical chemiluminescent immunoassay,and artery stenosis was assessed by color Doppler and transcranial Doppler.Patients were grouped according to the existence and location(intracranial vs.extracranial)of artery stenosis.Correlations between BTM levels,previous stroke,stenosis location,and glucose and lipid metabolism were analyzed.RESULTS T2DM patients with severe artery stenosis had a higher frequency of previous stroke and levels of all three tested BTMs(all P<0.05)than patients without.Some differences in OC and CTX levels were observed according to the location of artery stenosis.Significant associations were also observed between BTM levels and some glucose and lipid homeostasis parameters.On multivariate logistic regression analysis,all BTMs were significant predictors of artery stenosis in T2DM patients with and without adjustment for confounding factors(all P<0.001),and receiver operating characteristic curve analysis demonstrated the ability of BTM levels to predict artery stenosis in T2DM patients.CONCLUSION BTM levels were found to be independent risk factors for severe intracranial and extracranial artery stenosis and were differentially associated with glucose and lipid metabolism in patients with T2DM.Therefore,BTMs may be promising biomarkers and potential therapeutic targets for artery stenosis.
文摘背景与目的肺癌易发生骨转移,I型胶原羧基端肽β特殊序列(β isomer of C-terminal telopeptide of type I collagen,β-CTX)和骨源性碱性磷酸酶(bone-specific alkaline phosphates,BAP)在骨质代谢中是重要的生化标记物,本研究旨在探讨骨代谢生化指标和肺癌骨转移进展程度的相关性,有助于早期判断是否有肺癌骨转移的发生。方法天津市人民医院2009年7月-2012年7月共收治92例肺癌并发生骨转移患者,全部病例其原发灶均经细胞学检查证实,骨转移灶的数目及类型经ECT结合X线片、CT证实,采用ELISA方法检测血β-CTX、BAP的浓度水平。结果收集的92例肺癌伴骨转移的患者中,转移灶<3处为58例,≥3处为34例;溶骨型68例,成骨型9例,混合型15例。血β-CTX、BAP水平在不同的骨转移数目组间差异有统计学意义(P<0.05),β-CTX在肺癌溶骨型骨转移患者中具有较高的敏感性。结论骨代谢生化指标β-CTX、BAP对肺癌骨转移具有辅助诊断意义,是判断转移进展程度的良好指标。
文摘AIM:To investigate the postprandial response of bone turnover markers in patients with Crohn’s disease(CD).METHODS:Fifty nine patients with CD aged 38±14years,and 45 healthy individuals matched for age and body mass index were included in the study.All participants underwent an oral glucose tolerance test(OGTT)after an overnight fast and serum levels of the bone resorption marker C-terminal crosslinking telopeptide of type?Ⅰ?collagen(CTX-Ⅰ)and the bone formation marker procollagen type?Ⅰ?N propeptide were measured.Activity of the disease was assessed by calculation of the Crohn’s disease activity index(CDAI).RESULTS:Serum CTX-I was significantly higher in patients compared to controls(CTX-I:453±21 pg/mL vs 365±25 pg/mL,P=0.008),and values were significantly correlated with the activity of the disease(r=0.435,P=0.001).Results from OGTT-induced suppression of CTX-I showed two different trends.Patients with more active disease(assessed as CDAI>150)had a more excessive suppression of CTX-I compared to controls(55%vs 43%P<0.001),while patients on remission(assessed as CDAI<150)demonstrated an attenuated CTX-I suppression(30%vs 43%P<0.001).In line with this,CTX-I suppression after oral glucose load was significantly correlated with the activity of the disease(r=0.913,P<0.001).CONCLUSION:The physiological skeletal response of postprandial suppression of bone resorption is maintained in patients with CD and is strongly dependent to the activity of the disease.
文摘目的探讨高剂量维生素D补充剂治疗前、后骨质疏松症患者骨代谢标志物水平变化及意义。方法骨质疏松症患者100例,随机分为对照组和维生素D组各50例,对照组口服钙尔奇D 600mg/d;维生素D组在对照组基础上口服维生素D滴剂,1滴/d;2组均连续治疗6个月。分别于治疗前,治疗3、6个月时检测2组L_(2-4)、股骨颈及大转子骨密度(bone mineral density,BMD),采用电化学发光法检测血清Ⅰ型胶原羧基端肽β特殊序列(βisomer of C-terminal telopeptide of typeⅠcollagen,β-CTX)和Ⅰ型前胶原氨基端肽(procollagenⅠN-terminal peptide,PⅠNP)水平,并进行比较。结果维生素D组、对照组治疗前BMD在L_(2-4)[(0.683±0.006)、(0.681±0.007)g/cm^2]、股骨颈[(0.559±0.009)、(0.555±0.021)g/cm^2]、大转子[(0.421±0.011)、(0.418±0.011)g/cm^2]比较差异均无统计学意义(P>0.05);治疗6个月时维生素D组BMD在L_(2-4)、肢骨颈、大转子[(0.784±0.172)、(0.679±0.007)、(0.507±0.091)g/cm^2],对照组BMD在L_(2-4)、肢骨颈、大转子[(0.701±0.080)、(0.611±0.163)、(0.457±0.079)g/cm^2]均高于治疗前,且维生素D组高于对照组(P<0.05);2组治疗3个月时L_(2-4)、股骨颈、大转子BMD与治疗前比较差异均无统计学意义(P>0.05);维生素D组治疗前血清β-CTX[(0.74±0.05)μg/L]、PⅠNP[(42.10±3.50)μg/L]与对照组[(0.76±0.12)、(42.40±3.60)μg/L]比较差异无统计学意义(P>0.05);维生素D组及对照组治疗3个月β-CTX[(0.57±0.11)、(0.63±0.14)μg/L]、PⅠNP[(30.20±6.50)、(36.90±10.30)μg/L],治疗6个月β-CTX[(0.33±0.12)、(0.54±0.11)μg/L]、PⅠNP[(24.50±0.90)、(29.60±2.40)μg/L]均低于治疗前(P<0.05),且维生素D组低于对照组(P<0.05)。结论骨质疏松症患者应用高剂量维生素D补充剂治疗可增加BMD,降低血清PⅠNP、β-CTX水平,有助于延缓骨吸收,减少骨量丢失。
