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6种除草剂“安全剂”对咪唑乙烟酸的解毒效果评价 被引量:4
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作者 黄春艳 李静 +4 位作者 王宇 陈铁保 黄元炬 丛林 朴德万 《农药》 CAS 北大核心 2008年第9期682-685,共4页
以玉米做生测试材进行盆栽试验,研究萘二甲酐、对甲氧苯并呋喃、N-对氮苯磺酰基唑烷酮和农药降解菌单菌剂、复菌剂及有机处理复合剂6种除草剂"安全剂"对咪唑乙烟酸土壤残留的解毒效果。结果表明:咪唑乙烟酸有效成分用量为25... 以玉米做生测试材进行盆栽试验,研究萘二甲酐、对甲氧苯并呋喃、N-对氮苯磺酰基唑烷酮和农药降解菌单菌剂、复菌剂及有机处理复合剂6种除草剂"安全剂"对咪唑乙烟酸土壤残留的解毒效果。结果表明:咪唑乙烟酸有效成分用量为25、50、75ga.i./hm2,分别加入6种"安全剂"后,玉米的株高、鲜重和叶片数均高于无安全剂对照,筛选出了解毒效果较好的化学"安全剂"萘二甲酐及农药降解菌单菌剂和复菌剂。 展开更多
关键词 “安全剂” 咪唑乙烟酸 解毒效果
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Study on Safe Dosage of Imazethapyr for an Imazethapyr Resistant Millet Variety and Its Effect on Weed Control 被引量:3
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作者 张婷 师志刚 +4 位作者 陈媛 夏雪岩 相金英 耿光涛 程汝宏 《Agricultural Science & Technology》 CAS 2013年第6期911-914,共4页
[Objective] This study aimed to investigate the safe dosage of imazethapyr for an imazethapyr resistant millet variety and its effect on weed control. [Method] The Imazethapyr resistant millet "M1508" was used as th... [Objective] This study aimed to investigate the safe dosage of imazethapyr for an imazethapyr resistant millet variety and its effect on weed control. [Method] The Imazethapyr resistant millet "M1508" was used as the experimental material and the experiment was arranged in a split plot design with two factors: herbicide application time and herbicide dosage. Application time was taken as the main plot with six treatments: A1 (preemergence treatment), A2 (postemergence treatment on the 3rd d), A3 (postemergence treatment on the 6th d), A4 (postemergence treatment on the 9th d), A5 (postemergence treatment on the 12th d), A6 (postemergence treatment on the 15th d); spraying dosage(B) with nine treatments: B1 (0 ml/hm2 , taking water as control), B2 (750 ml/hm2 ), B3 (1 125 ml/hm2 ), B4 (1 500 ml/hm2 ), B5 (2 250 ml/hm2 ), B6 (3 000 ml/hm2 ), B7 (4 500 ml/hm2 ), B8 (6 000 ml/hm2), B9 (7 500 ml/hm2 ); water was added at 675 kg/hm2 . [Result] Imazethapyr showed a good herbicidal effect, and the imazethapyr resistant new variety M1508 also had a high drug resistance; the dosage range of 750 -7 500 ml/hm2 was safe for millet; considering the weed control efficacy, the yield and weeding cost comprehensively, postemergence treatment on the 6th day at 1 500 -2 250 ml/hm2 was the best for herbicide application. [Conclusion] Matched chemical weeding techniques to imazethapyr resistant millet varieties were preliminarily identified, and the efficacy of imazethapyr on weed control and its security on millet were investigated, providing references for the application and promotion of imazethapyr resistant millet varieties. 展开更多
关键词 IMAZETHAPYR HERBICIDE MILLET Security Efficacy
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Research Status of Amide Herbicides and Their Safeners 被引量:1
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作者 胡南 李玉 胡利锋 《Agricultural Science & Technology》 CAS 2016年第6期1379-1382,1478,共5页
The widespread use of chemical herbicides especially amide herbicides has promoted the innovation of chemical weeding in farmland, but amide herbicides have brought invisible chemical injuries to crops in addition to ... The widespread use of chemical herbicides especially amide herbicides has promoted the innovation of chemical weeding in farmland, but amide herbicides have brought invisible chemical injuries to crops in addition to weeding. Herbi-cidesafeners should be applied at the same time with herbicides to ensure herbi- cides will not injure crops while controlling weeds. The research and application of safeners is of great significance to resolving or alleviating the negative effects of herbicides on crop growth. The overview, mechanism, applied research progress and existing problems of amide herbicides and their safenars are summarized. 展开更多
关键词 Amide herbicides Safeners PROGRESS
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Is the Potential Interconnection between Antibiotic Susceptibility and Disinfectant Resistance a Threat to Food Safety?
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作者 周倩 唐梦君 +6 位作者 张静 张小燕 唐修君 陈大伟 顾荣 陆俊贤 高玉时 《Agricultural Science & Technology》 CAS 2017年第6期1033-1037,共5页
The prevalence of antibiotic susceptibility and disinfectant resistance in bacterial pathogens causes a serious problem not only to food safety but also to public health, which directly or indirectly leads to treatmen... The prevalence of antibiotic susceptibility and disinfectant resistance in bacterial pathogens causes a serious problem not only to food safety but also to public health, which directly or indirectly leads to treatment and disinfection failures. In this review, multidrug resistance, the mechanism of disinfectant resistance, the methods for detecting disinfectant resistance and the cross-resistance between an- tibiotics and disinfectants are summarized. More efforts should be devoted to explor- ing the professional guidance of using antibiotics and disinfectants, and to develop- ing the comprehensive detection with genetic and molecular methods is highly ex- pected. 展开更多
关键词 Food safety BACTERIA Antibiotic susceptibility Disinfectant resistance
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Efficacy and safety of novel anticoagulants in the elderly 被引量:3
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作者 Nikolaos Karamichalakis Stamatis Georgopoulos +4 位作者 Konstantinos Vlachos Ioarmis Liatakis Michael Efremidis Antonios Sideris Konstantinos P Letsas 《Journal of Geriatric Cardiology》 SCIE CAS CSCD 2016年第8期718-723,共6页
Atrial fibrillation and venous thromboembolism (VTE) are common disorders associated with maleficent thrombotic events, particularly in the elderly patients. Polypharmacy, co-morbidities, and altered pharmacokinetic... Atrial fibrillation and venous thromboembolism (VTE) are common disorders associated with maleficent thrombotic events, particularly in the elderly patients. Polypharmacy, co-morbidities, and altered pharmacokinetics, often present in these patients, render the use of antico-agulants quite challenging. Novel oral anticoagulants (NOACs) have recently emerged as alternatives to Vitamin K Antagonists (VKAs) and are gradually increasing their popularity mainly because of their fewer drug and food interactions and ease of use. Their effectiveness and safety has been weU-established in the general population but the balance between benefit and harm in the elderly is still unclear. Routine use in these patients is uncommon. Accumulating data have shown that the benefit of NOACs is consistent among all age groups, featuring equal or greater efficacy in preventing thrombotic events. Excess bleedings were lower with NOACs in comparison to VKAs, but bleeding patterns were disparate among them and head to head comparison is not available. The present review highlights on the efficacy and safety of novel anticoagulants in the elderly population. 展开更多
关键词 Atrial fibrillation EFFICACY Novel oral anticoagulants SAFETY Venous thromboembolism
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Traditional Chinese medicine compounds for the treatment of functional dyspepsia:an updated meta-analysis of randomized,double-blind,placebo-controlled trials 被引量:7
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作者 LUO Xiaoying YANG Yang +4 位作者 MAO Xinyong SONG Gengqing LIU Qian JIANG Tianyuan WEI Wei 《Digital Chinese Medicine》 2021年第4期273-289,共17页
Objective To evaluate the efficacy and safety of traditional Chinese medicine(TCM)compounds for the treatment of functional dyspepsia(FD).Methods The Pub Med,Embase,Cochrane Library,Web of Science,Chinese Biomedical D... Objective To evaluate the efficacy and safety of traditional Chinese medicine(TCM)compounds for the treatment of functional dyspepsia(FD).Methods The Pub Med,Embase,Cochrane Library,Web of Science,Chinese Biomedical Database(CBM),Wanfang Data,China National Knowledge Infrastructure(CNKI),and China Science and Technology Journal Database(VIP)were searched to collect randomized,double-blind,and placebo-controlled trials of FD treated with TCM compounds.The search duration was from the establishment of the database to March 2,2021.After two researchers independently screened the literature,extracted the data,and evaluated the bias risk included in the study,they used Rev Man 5.4 software for meta-analysis.Results A total of 23 clinical trials were included,including 2898 patients.Meta-analysis showed that the overall remission rate of FD treated with TCM compounds was significantly higher than that of placebo(73.8%vs.46.2%)[RR=1.50,95%CI(1.29,1.76),P<0.00001].Among the single symptoms,TCM compounds were superior to the placebo in improving epigastric pain[MD=﹣0.99,95%CI(﹣1.37,﹣0.61),P<0.00001],epigastric burning sensation[MD=﹣0.32,95%CI(﹣0.59,﹣0.05),P=0.02],postprandial fullness discomfort[MD=﹣1.59,95%CI(﹣1.96,﹣1.21),P<0.00001],and early satiety symptoms[MD=﹣0.93,95%CI(﹣1.32,﹣0.54),P<0.00001].Compared with the placebo,TCM compounds treatment can obviously improve TCM syndrome in patients with FD[MD=﹣5.58,95%CI(﹣7.55,﹣3.61),P<0.00001],gastric emptying rate[MD=12.22,95%CI(8.90,15.55),P<0.00001],and helped to improve patients’quality of life[MD=11.27,95%CI(0.10,22.43),P=0.05].No severe adverse events were reported between the two groups[RR=1.34,95%CI(0.91,1.96),P=0.14].Conclusion Our results showed that TCM compounds treatment could significantly alleviate FD symptoms,improve gastric emptying in FD patients,and help to improve their quality of life.No severe adverse reactions have been reported in clinical applications.Due to the limitation of the quantity and quality of the included studies,the above conclusions need to be verified by more high-quality studies. 展开更多
关键词 Functional dyspepsia Traditional Chinese medicine compounds PLACEBO EFFECTIVENESS Security
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Efficacy and safety of thalidomide in patients with hepatocellular carcinoma 被引量:21
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作者 Hsueh-Erh Chiou Tsang-En Wang +1 位作者 Ying-Yue Wang Hui-Wen Liu 《World Journal of Gastroenterology》 SCIE CAS CSCD 2006年第43期6955-6960,共6页
AIM: To evaluate which patients with hepatocellular carcinoma (HCC) are most likely to respond to thalidomide treatment. METHODS: From July 2002 to July 2004, patients with HCC who received thalidomide treatment, were... AIM: To evaluate which patients with hepatocellular carcinoma (HCC) are most likely to respond to thalidomide treatment. METHODS: From July 2002 to July 2004, patients with HCC who received thalidomide treatment, were enrolled. We extracted relevant data from the patients’ medical records, including history and type of hepatitis, comorbidity, serum α-fetoprotein (α-FP) level, volumetric changes in tumor, length of survival, and the dose, duration, side effects of thalidomide treatment. The tumor response was evaluated. On the basis of these data, the patients were divided into two groups: those with either partial response or stable disease (PR + SD group) and those with progressive disease (PD group). RESULTS: Two of 42 (5%) patients had a partial tumor response after treatment with thalidomide, 200 mg/d, and 9 (21%) had stable disease. Patients in the PR + SD group all had cirrhosis. Comparing patients with and without cirrhosis, the former were more likely to respond to thalidomide therapy (PR + SD: 100% vs PD: 64.5%, P = 0.041 < 0.05). Thalidomide was significantly more likely to be effective in tumors smaller than 5 cm (PR + SD: 63.6% vs PD: 25.8%, P = 0.034 < 0.05). Compared with patients with progressive disease (PD), patients in the PR + SD group had a higher total dose of thalidomide (13 669.4 ± 8446.0 mg vs 22 022.7 ± 11 461.4 mg, P = 0.023 < 0.05) and a longer survival (181.0 ± 107.1 d vs 304.4 ± 167.1 d, P = 0.047 < 0.05). Patients with comorbid disease had a significantly greater incidence of adverse reactions than those without (93.8% vs 60.0%, P = 0.021 < 0.05). The average number of adverse reactions in each person with a comorbid condition was twice as high as in those without other diseases (2.2 ± 1.3 vs 1.1 ± 1.2; P = 0.022 < 0.05). CONCLUSION: Thalidomide therapy is most likely to beeffective in patients with early stage small HCC, espe- cially in those with other underlying diseases. A low dose (200 mg/d) of thalidomide is recommended to continue the treatment long enough to make it more effective. 展开更多
关键词 THALIDOMIDE Hepatocellular carcinoma Antiangiogenic agents Adverse events
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Herbicide Safeners Increase Waxy Maize Tolerance to Nicosulfuron and Affect Weed Control
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作者 Lanlan Sun Renhai Wu +2 位作者 Wangcang Su Zenggui Gao Chuantao Lu 《Journal of Agricultural Science and Technology(A)》 2016年第6期386-393,共8页
Safeners are an important tool used to ensure the safe using of herbicide. This research was conducted to determine the effects of nicosulfuron alone and in combination with herbicide safeners on waxy maize (Zea mays... Safeners are an important tool used to ensure the safe using of herbicide. This research was conducted to determine the effects of nicosulfuron alone and in combination with herbicide safeners on waxy maize (Zea mays L. var. ceratina Kulesh) injury, as well as on barnyard grass (Echinochioa crus-galli) and large crabgrass control (Digitaria sanguinalis L. Scop). Whole-plant experiments were conducted under laboratory condition, by using post emergence treatment with safeners and nicosulfuron. The results showed that the herbicide safeners isoxadifen-ethyl (IE) and cyprosulfamide (CS) were more effective in reducing waxy maize injury from nicosulfuron than fenchlorazole-ethyl (FE), cloquintocet-mexyl (CM) and mefenpyr-diethyl (MD). Whole-plant dose-response experiments showed that nicosulfuron in combination with IE or CS increased its herbicidal activities against barnyard grass and large crabgrass. To confirm the result, a mixture of IE or CS and nicosulfuron were sprayed on waxy maize in the field, by using a backpack plot sprayer with a flat-fan nozzle. The mixture led to lower phytotoxicity than nicosulfuron alone. The mixture tested did not affect the maize grain weight. The results showed that IE and CS could enhance crop safety and extend the use of nicosulfuron on waxy maize. 展开更多
关键词 Cyprosulfamide Digitaria sanguinalis Echinochioa crus-galli isoxadifen-ethyl phytotoxicity.
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Application of the High Molecular Water-keeping Compound Sodium Polyacrylate in Agriculture 被引量:1
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作者 Li Qingfeng,Liu Delin,Jin Longxin,and Wu Lijun Hunan Institute of Atomic Energy Application in Agriculture,Changsha 410125,China 《Hunan Agricultural Science & Technology Newsletter》 2001年第4期24-26,共3页
The properties of the high molecular water-absorbing compound sodium polyacrylate (SP) and its application in agriculture are reviewed;and its safety in application is also introduced.
关键词 sodium polyacrykte high molecular water-absorbing material agricultural application
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Isolation, Characterization and Bio-Control Activities of Bacillus Subtilis from the Fermented Soybean in Cambodia
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作者 Ek Sopheap Yasuhiro Inatsu +1 位作者 Huon Thavrak Buntong Borarin 《Journal of Food Science and Engineering》 2018年第4期171-188,共18页
The objective of this study was to isolate Bacillus subtilis produced Bacteriocin from Khmer traditional fermented soybean to control the growth of pathogenic bacteria from 120 SIENG samples from 9 different loca... The objective of this study was to isolate Bacillus subtilis produced Bacteriocin from Khmer traditional fermented soybean to control the growth of pathogenic bacteria from 120 SIENG samples from 9 different local open markets in Phnom Penh, 1 local open market and 2 local producers in Kandal province in Cambodia. 119 out of 120 samples were positive with Bacillus subtilis strains. Fifteen of these isolated strains exhibited antimicrobial activity to Lactobacillus plantarum by agar well diffusion assay and one of them (CeM6-7 strain) exhibited strongest antimicrobial activity. The filtered supernatant of this strain also suppressed the growth of several Gram-positive pathogens (such as Staphylococcus aureus) or lactic acid bacteria in broth. The filtrate could also suppress the growth of L. plantarum inoculated into soymilk. Antimicrobial B. subtilis strain CeM6-7 is thought to be applicable for making a starter culture to produce much safe fermented soybean foods by suppressing the growth of naturally contaminated B. cereus or S. aureus during production. In addition, the use of this starter culture may contribute to prevent spoilage or quality loss of soybean products caused by the over growth lactic acid bacteria or other Gram-positive bacteria. 展开更多
关键词 B. subtilis fermented soybean BACTERIOCIN food poisoning spoilage bacterial.
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Antibiotic susceptibility of strains in Chinese medical probiotic products
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作者 唐欢 袁静 +1 位作者 谢彩虹 魏泓 《Journal of Medical Colleges of PLA(China)》 CAS 2007年第3期149-152,共4页
Objective: To investigate the susceptibility of strains separated from probiotic products for medical purpose to 14 antimicrobial agents. Methods:The single aerobic strains were isolated from these products respecti... Objective: To investigate the susceptibility of strains separated from probiotic products for medical purpose to 14 antimicrobial agents. Methods:The single aerobic strains were isolated from these products respectively and disc agar diffusion assay was proceeded to determine the susceptibility. Results: Probiotics tested in the study mostly showed multiresistant to the agents. Lactobacillus acidophilus LAP, LAB, Lactobacillus bulgaricus LBJ and Streptococcus therrnophilus STJ were resistant to vancomycin. Conclusion: Drug resistance exists in most of commercial probiotics. The evaluation and monitoring of safety of probiotic products for medical purpose should be paid great attention. 展开更多
关键词 PROBIOTICS antimicrobial resistan drug safety
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Visible light induced TiO_2 pillared MMT photocatalyst coupling-doped with S and N
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作者 周安宁 陈有梅 于占江 《Journal of Coal Science & Engineering(China)》 2008年第3期517-519,共3页
Visible light induced titanium dioxide (TiO2) pillared montmorillonite clay (MMT) photocatalyst coupling-doped with S and N elements was prepared by the two-step ad- sorption method.The photocatalyst was characterized... Visible light induced titanium dioxide (TiO2) pillared montmorillonite clay (MMT) photocatalyst coupling-doped with S and N elements was prepared by the two-step ad- sorption method.The photocatalyst was characterized by X-ray photoelectron spectros- copy (XPS) and ultraviolet-visible (UV-vis) absorption spectroscopy.The photocatalysic ef- ficacy of the prepared photocatalyst for degrading gaseous formaldehyde was evaluated under visible light irradiation.The degrading rate of gaseous formaldehyde is nearly 85% in 300 min visible light irradiation.The results demonstrate that the much higher visible light photocatalytic activity of the photocatalyst is due to the synergistic effects of coupling- doping of S and N elements to TiO2,extensive specific surface area of MMT and quantum sized efficacy between layers of MMT. 展开更多
关键词 visible light pillared MMT PHOTOCATALYST coupling-doping gaseous formaldehyde
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Analysis and Countermeasures Research of Beijing Country Fair
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作者 Danshu Qi 《International Journal of Technology Management》 2014年第6期94-96,共3页
Organic vegetables, does not use pesticides, synthetic fertilizers, herbicides, growth regulators in production process and refers to organisms and products got from genetic engineering. It follows the laws of nature ... Organic vegetables, does not use pesticides, synthetic fertilizers, herbicides, growth regulators in production process and refers to organisms and products got from genetic engineering. It follows the laws of nature and ecological principles, adopts a series of sustainable development of agricultural technology, to coordinate planting balanced, and stable agricultural ecosystems, and through the identification of organic certification, it will be recognized and awarded organic certification. Beijing Country Fair launched by a group of consumer volunteers concerned about ecological agriculture and rural issues, aiming to build a platform for farmers engaged in organic agriculture and consumers can communicate directly, exchange. It can help consumers find safe, assured products, but also help farmers to broaden market channels and encourage more farmers to engage in organic farming, thereby reducing environmental pollution produced by fertilizer and pesticide, safeguarding food security, and practicing fair trade. 展开更多
关键词 Countermeastues BEIJING Cotmtry Fair Organic vegetables.
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Heat and Radiation Generation during Hydrogenation of CH Compound
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作者 T. Mizuno 《Journal of Environmental Science and Engineering》 2011年第8期1017-1025,共9页
Securing new sources of energy has become a major concern, because fossil fuels are expected to be depleted within several decades. In some of the major wars of the 20th century, control of oil was either a proximate ... Securing new sources of energy has become a major concern, because fossil fuels are expected to be depleted within several decades. In some of the major wars of the 20th century, control of oil was either a proximate cause or a decisive factor in the outcome. Especially in Japan and Germany, a great deal of research was devoted to making liquid fuels from coal. In one such experiment, a large amount of excess heat was observed. The present study was devoted to replicating and controlling that excess heat effect. The reactant is phenanthrene, a heavy oil fraction, which is subjected to high pressure and high heat in the presence of a metal catalyst. This results in the production of excess heat and strong penetrating electromagnetic radiation. After the reaction, an analysis of residual gas reveals a variety of hydrocarbons, but it seems unlikely that these products can explain the excess heat. Most of them form endothermically, and furthermore heat production reached 60 W. Overall heat production exceeded any conceivable chemical reaction by two orders of magnitude. 展开更多
关键词 Heat generation HYDROGEN carbon catalyzer
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Study on Weed Control and Safety of Tembotrione-Atrazine Tank Mixture in Spring Maize Fields
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作者 SHAO Jia-li SUN Jin-jun DUAN Gui-fang 《Agricultural Science & Technology》 CAS 2022年第1期28-31,38,共5页
This study aimed to explore the effect of 5% tembotrione oil dispersion(OD)-38% atrazine suspension concentrate(SC) tank mixture on the weeds in spring maize fields and the safety of the mixture. To be specific, rando... This study aimed to explore the effect of 5% tembotrione oil dispersion(OD)-38% atrazine suspension concentrate(SC) tank mixture on the weeds in spring maize fields and the safety of the mixture. To be specific, randomized block design was adopted for the field experiments. The results showed that the application of tankmixture of 5% tembotrione OD at 90 g a.i./hm^(2)and 38% atrazine SC at 570 g a.i./hm^(2)and the mixture of 5% tembotrione OD at 90 g a.i./hm^(2)and 38% atrazine SC at 1140 g a.i./hm^(2)respectively controlled 94.7%~96.3% and 94.0%~96.3% of the grass weeds, 94.7%~96.0% and 93.7%~95.7% fresh weight of grass weeds, 95.3%~96.3%and 93.3%~97.3% of broadleaf weeds, and 94.7%~96.0% and 93.3%~96.3% fresh weight of broadleaf weeds. The efficacy was better than that of the 5% tembotrione alone and the control herbicide and no phytotoxicity of the mixtures was identified.The tank mixture of tembotrione and atrazine should be promoted in the spring maize field for weed control and the recommended dosages were 90 g a.i./hm^(2)for 5%tembotrione and 570 g a.i./hm^(2)for 38% atrazine. 展开更多
关键词 5%Tembotrione OD 38%Atrazine SC MAIZE Weed control Crop safety
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Understanding the Safety, Health and Environmental (SHE) Challenges of Xenobiotics and Their Remedial Approaches
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作者 M.S. Tango A.B. Chhetri E. Vost 《Journal of Environmental Science and Engineering》 2011年第8期992-1002,共11页
With the use of over 100,000 industrially produced chemicals, there have been several concerns on human health and environment. Most of these chemicals are exposed into the natural environment during the life cycles o... With the use of over 100,000 industrially produced chemicals, there have been several concerns on human health and environment. Most of these chemicals are exposed into the natural environment during the life cycles of their production, transportation, storage, consumption, and as by-products and wastes. The rising rates of cancer, obesity, and infertility suggests that there are compounds recently introduced to the environment that have altered the chemistry of the human body, and it is only with the monitoring of xenobiotics such as Bisphenol A (BPA), nonyphenols, estrogen (natural and synthetic) and other endocrine-disrupting compounds (EDCs) that patterns and links could be drawn. This paper investigates the safety, environmental and health (SHE) impacts caused by BPA, nonyphenols and estrogens. Derived from petroleum, bisphenol A is used in manufacturing plastic consumer products, including certain water bottles, in dental sealants for children's teeth, and in resins used to line tin cans. Nonyphenol is one of the by-products of alkylphenolpolyethoxilates which is widely used as nonionic surfactants. Synthetic estrogen used for birth control pills as well as natural estrogen excreted by women through urine enters the domestic wastewater streams. These compounds are considered to be EDCs and have severe SHE concerns. In this paper, the challenges of entry of these compounds (xenobiotics) into nature, health and environmental issues and their remediation have been reviewed in detail. 展开更多
关键词 Industrially produced chemicals bisphenol A nonyphenols endocrine-disrupting compounds (EDCs) remedial measures xenobiotics.
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Repeated exposure to moxa-burning smoke: its acute and chronic toxicities in rats 被引量:5
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作者 Han Li Liu Changxi +10 位作者 Liu Ping Hu Hai Yang Jia Cai Hong Lim Minyee Zhu Maoxiang Pan Xiujie Huang Jian Cui Yingxue Lao Lixing Zhao Baixiao 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2018年第1期67-75,共9页
OBJECTIVE: To assess toxicities of the air in Chinese medicine clinics polluted by moxa-burning smoke due to moxibustion-derived burning products (MBP). METHODS: Both acute and chronic toxicity studies were conduc... OBJECTIVE: To assess toxicities of the air in Chinese medicine clinics polluted by moxa-burning smoke due to moxibustion-derived burning products (MBP). METHODS: Both acute and chronic toxicity studies were conducted. For the acute toxicity study, five groups of Wistar rats (n = 16/group, male: female = 1 : 1) were exposed to five different concentrations (95%, 90%, 85%, 80% and 75%, respectively) of MBP for 2 h. For the chronic toxicity study, another three groups of male rats (n = 21/group) were ex- posed to MBP in three concentrations (10%, 40% and 70%, respectively) and one control group ex- posed to clean air 20 min/d for 144 d. Routine ex- aminations were performed and analyzed by analy- sis of variance and dose-response relationship. RESULTS: In the acute toxicity study, the number of dead rats in the 95%, 90%, 85%, 80% and 75% groups were 16, 13, 7, 6 LDS0 of 86.274% after or and 3, respectively, with during the 2 h exposure. In the chronic toxicity study, MBP exposure induced a decline in activity of the rats. Rats in the 10% group showed no signs of toxicity, while those in the 40% MBP group showed toxicity effects on the body weights (P 〈 0.05) and lung. Rats in the 70% MBP group also presented with reversible damage in the blood coagulation system (P 〈 0.05). CONCLUSION: Exposure to 10% MBP, which is equivalent to 27.45 mg/m^3 was under the critical threshold for male rats'safety. Exposure to MBP above that limit induced lung damage. MBP in clinics need to be reduced to a safe level with enhanced ventilation. 展开更多
关键词 SMOKE MOXIBUSTION Environmental exposure Toxicity tests
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Efficacy and safety of chiglitazar,a novel peroxisome proliferatoractivated receptor pan-agonist,in patients with type 2 diabetes:a randomized,double-blind,placebo-controlled,phase 3 trial(CMAP) 被引量:19
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作者 Linong Ji Weihong Song +29 位作者 Hui Fang Wei Li Jianlin Geng Yangang Wang Lian Guo Hanqing Cai Tao Yang Hongmei Li Gangyi Yang Qifu Li Kuanzhi Liu Shuying Li Yanjun Liu Fuyan Shi Xinsheng Li Xin Gao Haoming Tian Qiuhe Ji Qing Su Zhiguang Zhou Wenbo Wang Zunhai Zhou Xuejun Li Yancheng Xu Zhiqiang Ning Haixiang Cao Desi Pan He Yao Xianping Lu Weiping Jia 《Science Bulletin》 SCIE EI CSCD 2021年第15期1571-1580,M0004,共11页
Chiglitazar(Carfloglitazar)is a novel non-thiazolidinedione(TZD)structured peroxisome proliferatoractivated receptor(PPAR)pan-agonist that has shown promising effects on glycemic control and lipid regulation in patien... Chiglitazar(Carfloglitazar)is a novel non-thiazolidinedione(TZD)structured peroxisome proliferatoractivated receptor(PPAR)pan-agonist that has shown promising effects on glycemic control and lipid regulation in patients with type 2 diabetes in previous clinical studies.This randomized phase 3 trial aimed to compare the efficacy and safety of chiglitazar with placebo in patients with type 2 diabetes with insufficient glycemic control by strict diet and exercise alone.Eligible patients were randomly assigned to receive chiglitazar 32 mg(n=167),chiglitazar 48 mg(n=166),or placebo(n=202)once daily.The primary endpoint was the change in glycosylated hemoglobin A_(1c)(HbA_(1c))at week 24 with superiority of chiglitazar over placebo.The results showed that both chiglitazar 32 and 48 mg resulted in significant and clinically meaningful reductions in HbA_(1c),and placebo-adjusted estimated treatment differences at week 24 for chiglitazar 32 and 48 mg were-0.87%(95%confidential interval(CI):-1.10 to-0.65;P<0.0001)and-1.05%(95%CI:-1.29 to-0.81;P<0.0001),respectively.Secondary efficacy parameters including glycemic control,insulin sensitivity and triglyceride reduction were also significantly improved in the chiglitazar groups.The overall frequency of adverse events and study discontinuation attributable to adverse events were similar among the groups.Low incidences of mild edema and body weight gain were reported in the chiglitazar dose groups.The results from this phase 3 trial demonstrated that the PPAR pan-agonist chiglitazar possesses an overall good efficacy and safety profile in patients with type 2 diabetes inadequately controlled with lifestyle interventions,thereby providing adequate supporting evidence for using this PPAR pan-agonist as a treatment option for type 2 diabetes. 展开更多
关键词 Chiglitazar Carfloglitazar PPAR pan-agonist
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Clinical efficacy and safety of Gandouling plus low-dose D-penicillamine for treatment of Wilson's disease with neurological symptoms 被引量:3
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作者 Zhang Jing Li Liangyong +1 位作者 Chen Huaizhen Yang Wenming 《Journal of Traditional Chinese Medicine》 SCIE CAS CSCD 2018年第1期89-94,共6页
OBJECTIVE: To investigate the effect and safety of Gandouling plus low-dose D-penicillamine for treating patients with Wilson's disease (WD) who have neurological symptoms. METHODS: WD patients with neurological ... OBJECTIVE: To investigate the effect and safety of Gandouling plus low-dose D-penicillamine for treating patients with Wilson's disease (WD) who have neurological symptoms. METHODS: WD patients with neurological symptoms were divided into two groups: a treatment group (n = 53) and a control group (n = 50). The treatment group received anti-copper therapy with a combination of Gandouling and low-dose D-peni- cillamine (10 mglkg), whereas the control group was with conventional dose D-penicillamine (20 rag/ kg) monotherapy. The clinical efficacies, adverse re- actions, and results of the various hematological and biochemical investigations were recorded and analyzed statistically. RESULTS: Overall, 98.11% of the WD patients treated with the combined therapy experienced alleviation of their neurological condition (paralleled by a significantly improved Global Assessment Scale score or remained stable). Their white blood cell and platelet counts stabilized, and their liver function was improved or remained stable. The combined therapy also obviously promoted improved 24-h urinary copper excretion. Only 15.09% of the WD patients with the combined therapy experienced adverse reactions, including neurological deterioration in one case (1.89%) and hepatic worsening in one case (1.89%), which was less frequent than that in the control group given conventional-dose D-penicillamine monotherapy. CONCLUSION: Treating WD patients with neurological symptoms using Gandouling plus low-close D-penicillamine is effective and safe. 展开更多
关键词 Hepatolenticular degeneration Penicillaminate Neurologic manifestations Gandouling
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Simulating Experimental Investigation on the Safety of Nuclear Heating Reactor in Loss-of-Coolant Accidents
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作者 Zhanjie Xu(Institute of Nuclear Energy Technology, Tsinghua University, Beijing, 100084, China) 《Journal of Thermal Science》 SCIE EI CAS CSCD 1996年第4期285-291,共7页
The 5MW low temperature nuclear heating reactor (NHR-5) is a new and advanced type of nuclear reactor developed by Institute of Nuclear Energy Technology (INET) of Tsinghua University of China in 1989. Its main loop i... The 5MW low temperature nuclear heating reactor (NHR-5) is a new and advanced type of nuclear reactor developed by Institute of Nuclear Energy Technology (INET) of Tsinghua University of China in 1989. Its main loop is a thermal-hydraulic system with natural circulation. This paper studies the safety of NHR under the condition of loss-of-coolant accidents (LOCAs) by means of simulant experiments. First, the background and necessity of the experiments are presented, then the experimental system, including the thermal-hydraulic system and the data collection system, and similarity criteria are introduced. UP to now, the discharge experiments with the residual heating power (20% rated heating power) have been carried out on the experimental system. The system parameters including circulation flow rate, system pressure, system temperature, void fraction, discharge mass and so on have been recorded and analyzed. Based on the results of the experiments, the conclusions are shown as folios: on the whole, the reactor is safe under the condition of LOCAs, but the thermal vacillations resulting from the vibration of the circulation flow rate are disadvantageous to the internal parts of the reactor core. 展开更多
关键词 nuclear heating reactor natural circulation LOCA safety.
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