Aim Toshorten integral design period of electric vehicles Methods The electric vehicle simulation program(EVSP), a modular user-friendly program which is written in Borland C++ OWL for Windows was developed. Results ...Aim Toshorten integral design period of electric vehicles Methods The electric vehicle simulation program(EVSP), a modular user-friendly program which is written in Borland C++ OWL for Windows was developed. Results EVSP allows simulating the dynamic and the economy performance of electric vehicles.EVSP provides many kinds of data input module,a large components library of electric vehicles and several kinds of speed cycle with these library,it is easily to develop a new concept of different drive trains or even to compare or improve the existing electric vehicles. The paper simulated the performance of YW6120DD Electric Bus, and analyzed the test results comparing with simulation results Conclusion The simulation results indicate that the EVSP may contribute to the developments of electric vehicles in general and the definition of the optimal match management in the drive train in particular.展开更多
The systematical and scalable frameworks were provided for estimating the blocking probabilities under asynchronous traffic in optical burst switching(OBS) nodes with limited wavelength conversion capability(LWCC) . T...The systematical and scalable frameworks were provided for estimating the blocking probabilities under asynchronous traffic in optical burst switching(OBS) nodes with limited wavelength conversion capability(LWCC) . The relevant system architectures of limited range and limited number of wavelength converters(WCs) deployed by a share-per-fiber(SPF) mode were developed,and the novel theoretical analysis of node blocking probability was derived by combining the calculation of discouraged arrival rate in a birth-death process and two-dimensional Markov chain model of SPF. The simulation results on single node performance verify the accuracy and effectiveness of the analysis models. Under most scenarios,it is difficult to distinguish the plots generated by the analysis and simulation. As the conversion degree increases,the accuracy of the analysis model worsens slightly. However,the utmost error on burst loss probability is far less than one order of magnitude and hence,still allows for an accurate estimate. Some results are of actual significance to the construction of next-generation commercial OBS backbones.展开更多
The growing interest in skeletal muscle regeneration is associated with the opening of new therapeutic strategies for muscle injury after trauma, as well as several muscular degenerative pathologies, including dystrop...The growing interest in skeletal muscle regeneration is associated with the opening of new therapeutic strategies for muscle injury after trauma, as well as several muscular degenerative pathologies, including dystrophies, muscu- lar atrophy, and cachexia. Studies focused on the ability of extracellular factors to promote myogenesis are therefore highly promising. We now report that an adipocyte-derived factor, globular adiponectin （gAd）, is able to induce mus- cle gene expression and cell differentiation, gAd, besides its well-known ability to regulate several metabolic func- tions in muscle, including glucose uptake and consumption and fatty acid catabolism, is able to block cell cycle entry of myoblasts, to induce the expression of specific skeletal muscle markers such as myosin heavy chain or caveolin-3, as well as to provoke cell fusion into multinucleated syncytia and, finally, muscle fibre formation, gAd exerts its pro- differentiative activity through redox-dependent activation of p38, Akt and 5＇-AMP-activated protein kinase path- ways. Interestingly, differentiating myoblasts are autocrine for adiponectin, and the mimicking of pro-inflammatory settings or exposure to oxidative stress strongly increases the production of the hormone from differentiating cells. These data suggest a novel function of adiponectin, directly coordinating the myogenic differentiation program and serving an autocrine function during skeletal myogenesis.展开更多
A measurement campaign has been conducted at 2.35 GHz with a bandwidth of 50 MHz to ob- tain the statistics and evaluate the capacity of the backhaul link. Based on the measured channel im- pulse response, the channel...A measurement campaign has been conducted at 2.35 GHz with a bandwidth of 50 MHz to ob- tain the statistics and evaluate the capacity of the backhaul link. Based on the measured channel im- pulse response, the channel gain, the eigenvalue statistics and the capacity are investigated. The distribution and corresponding parameters for describing the eigenvalue dispersion, the maximum and minimum eigenvalues are given. It is found that the backhaul link is relatively stable, which shows small variance of the channel gain. In spite of the fact that there are not many scatterers in the backhaul link, the channel rank can be enhanced by using dual-polarized antennas. Thus, the backhaul link can provide enough capacity.展开更多
AIM： To investigate a potential role of S100A4 in esoph- agus squamous cell carcinoma metastasis （ESCCs）.METHODS： Expression of $100A4 and E-cadherin were analyzed in frozen sections from ESCCs （metastasis, n = 2...AIM： To investigate a potential role of S100A4 in esoph- agus squamous cell carcinoma metastasis （ESCCs）.METHODS： Expression of $100A4 and E-cadherin were analyzed in frozen sections from ESCCs （metastasis, n = 28; non-metastasis, n = 20） by reverse transcrip- tion-polymerase chain reaction, quantitative polymerase chain reaction and immunohistochemistry. To explore the influence of $100A4 on esophageal cancer invasion and metastasis, $100A4 was overexpressed or silenced by $100A4 siRNA in TE-13 or Eca-109 cells/n vitro and /n vivo.展开更多
AIM: To investigate whether the side population (SP) cells possess cancer stem cell-like characteristics in vitro and the role of SP cells in tumorigenic process in gastric cancer. METHODS: We analyzed the presence of...AIM: To investigate whether the side population (SP) cells possess cancer stem cell-like characteristics in vitro and the role of SP cells in tumorigenic process in gastric cancer. METHODS: We analyzed the presence of SP cells indifferent human gastric carcinoma cell lines, and then isolated and identified the SP cells from the KATO Ⅲ human gastric cancer cell line by flow cytometry. The clonogenic ability and self-renewal were evaluated by clone and sphere formation assays. The related genes were determined by reverse transcription polymerase chain reaction. To compare tumorigenic ability, SP and non-side population (NSP) cells from the KATO Ⅲ human gastric cancer cell line were subcutaneously injected into nude mice. RESULTS: SP cells from the total population accounted for 0.57% in KATO Ⅲ, 1.04% in Hs-746T, and 0.02% in AGS (CRL-1739). SP cells could grow clonally and have self-renewal capability in conditioned media. The expression of ABCG2, MDRI, Bmi-1 and Oct-4 was different between SP and NSP cells. However, there was no apparent difference between SP and NSP cells when they were injected into nude mice. CONCLUSION: SP cells have some cancer stem celllike characteristics in vitro and can be used for studying the tumorigenic process in gastric cancer.展开更多
Each secretion （See） machinery minimally consists of three integral inner membrane pro- teins SecYEG. In order to know the distribution pattern of the Sec complex in Streptococcus mutans, we explored the subcellular...Each secretion （See） machinery minimally consists of three integral inner membrane pro- teins SecYEG. In order to know the distribution pattern of the Sec complex in Streptococcus mutans, we explored the subcellular localization of SecY. The anti-secY antibody was examined on Western blots to evaluate specificity. An indirect post-embedding immunogold method was used to determine the subcellular localization of the SecY in the cytoplasmic membrane of the Streptococcus mutans GS-5. lmmunoblotting experiments showed that the anti-seeY antibody specifically recognized a single band of about 47.8 kDa. Immunogold electron microscopy image of section with anti-secY antibody revealed a single intense focus of gold particles at a discrete location on the cytoplasmic membrane of the Streptococcus mutans GS-5. SecY clustered to an asymmetric microdomain, which indicated for the first time that See complex presented a unisite on the cytoplasmic membrane of Streptococcus mutans.展开更多
From the five-force model application in enterprises, this paper analyzes the five-force model in the development of cruise industry in shanghai which is based on the background of supply-side structural reform. As a ...From the five-force model application in enterprises, this paper analyzes the five-force model in the development of cruise industry in shanghai which is based on the background of supply-side structural reform. As a result, getting the answer of the cruise industry of corresponding relationship with the access capability of potential competitors, the bargaining capability of suppliers and buyers, the replacing capability of substitutes, industry competitors existing competition ability. From these relations, it summarizes the cruise industry core competitive advantages, such as high quality service, high differentiation of user experience and so on. At last, through the corresponding analyze of the strategy, providing useful advice for the sustainable development of cruise industry.展开更多
To provide a risk-sharing mechanism that encourages a component supplier and a manufacturer to expand their production capacity of components and products, many researches on SCM suggested that it is better for the SC...To provide a risk-sharing mechanism that encourages a component supplier and a manufacturer to expand their production capacity of components and products, many researches on SCM suggested that it is better for the SC players to connect a long-term contract with flexible preconditions before doing the decision-making of production capacity. With considering of the uncertainty of demand and integrity problems between SC players, it is difficult to set reasonable preconditions. As a result, under-investment problems still occur frequently. In this paper, after we had discussed the decision-making of production capacity with the preconditions by analyzing the character of the players, we verified the under-investment problem of the supply chain. In order to clarify the optimum preconditions to alleviate the under-investment problem, we also analyzed the relations between preconditions and supply capacity of the whole supply chain. In the last part of this paper, we proposed a method of preconditions setting in such uncertain situations.展开更多
This study aims to investigate and explore the relationship between vertical integration and the firm＇s innovativeness in food supply chain. For doing so, a two-stage least-squares model was used. It encompassed inst...This study aims to investigate and explore the relationship between vertical integration and the firm＇s innovativeness in food supply chain. For doing so, a two-stage least-squares model was used. It encompassed instrumental variables that attempt to describe the effective determinants of firm＇s vertical integration willingness. Results based on data concerning a set of 130 food-manufacturing firms, highlighted that vertical integration of a firm is strongly affected by internal incentives such as innovation rate and firm size. Moreover, it is simultaneously influenced by the economies of scale and some structure incentives. To conclude, results indicate globally that important and statistically significant differences exist across the studied firms and the small effective ones which acquire a high level of vertical integration.展开更多
The research performed analysis on differences of physiological property and yield of Tiejing No. 11 by different nitrogen fertilization patterns. The results indicated that while the nitrogen of basal: tillering: pan...The research performed analysis on differences of physiological property and yield of Tiejing No. 11 by different nitrogen fertilization patterns. The results indicated that while the nitrogen of basal: tillering: panicle was 6 ∶3∶1, the higher amount of nitrogen improved the chlorophyll content, photosynthetic capacity, effective panicle, grain weight and yield; the medium nitrogen level had advantage under the ratio 4:3:3; nitrogen application at lategrowth stage was suitable for low or medium nitrogen level,which could increase photosynthetic capacity and optimize the yield components and increase yield; under the same ratio for basic tiller and ear fertilizer, the increase of nitrogen could improve total nitrogen uptake and protein content, decrease nitrogen physiological efficiency and milled rice and tasting, but nitrogen recovery and harvest index changes had difference; as application at late growth stage in same nitrogen rate, total nitrogen uptake and protein content increased, nitrogen physiological efficiency and milled rice and amylose content and tasting decreased, nitrogen recovery and harvest index increased under low or medium nitrogen level and decreased under high nitrogen level. Nitrogen application 210 kg/hm^2 and the ratio 4 ∶3 ∶3 of basal:tillering: panicle made the yield increase by 2.8%-11.3%, and this is the optimal mode of nitrogen fertilizer application.展开更多
文摘Aim Toshorten integral design period of electric vehicles Methods The electric vehicle simulation program(EVSP), a modular user-friendly program which is written in Borland C++ OWL for Windows was developed. Results EVSP allows simulating the dynamic and the economy performance of electric vehicles.EVSP provides many kinds of data input module,a large components library of electric vehicles and several kinds of speed cycle with these library,it is easily to develop a new concept of different drive trains or even to compare or improve the existing electric vehicles. The paper simulated the performance of YW6120DD Electric Bus, and analyzed the test results comparing with simulation results Conclusion The simulation results indicate that the EVSP may contribute to the developments of electric vehicles in general and the definition of the optimal match management in the drive train in particular.
基金Project(60632010) supported by the National Natural Science Foundation of China
文摘The systematical and scalable frameworks were provided for estimating the blocking probabilities under asynchronous traffic in optical burst switching(OBS) nodes with limited wavelength conversion capability(LWCC) . The relevant system architectures of limited range and limited number of wavelength converters(WCs) deployed by a share-per-fiber(SPF) mode were developed,and the novel theoretical analysis of node blocking probability was derived by combining the calculation of discouraged arrival rate in a birth-death process and two-dimensional Markov chain model of SPF. The simulation results on single node performance verify the accuracy and effectiveness of the analysis models. Under most scenarios,it is difficult to distinguish the plots generated by the analysis and simulation. As the conversion degree increases,the accuracy of the analysis model worsens slightly. However,the utmost error on burst loss probability is far less than one order of magnitude and hence,still allows for an accurate estimate. Some results are of actual significance to the construction of next-generation commercial OBS backbones.
文摘The growing interest in skeletal muscle regeneration is associated with the opening of new therapeutic strategies for muscle injury after trauma, as well as several muscular degenerative pathologies, including dystrophies, muscu- lar atrophy, and cachexia. Studies focused on the ability of extracellular factors to promote myogenesis are therefore highly promising. We now report that an adipocyte-derived factor, globular adiponectin （gAd）, is able to induce mus- cle gene expression and cell differentiation, gAd, besides its well-known ability to regulate several metabolic func- tions in muscle, including glucose uptake and consumption and fatty acid catabolism, is able to block cell cycle entry of myoblasts, to induce the expression of specific skeletal muscle markers such as myosin heavy chain or caveolin-3, as well as to provoke cell fusion into multinucleated syncytia and, finally, muscle fibre formation, gAd exerts its pro- differentiative activity through redox-dependent activation of p38, Akt and 5＇-AMP-activated protein kinase path- ways. Interestingly, differentiating myoblasts are autocrine for adiponectin, and the mimicking of pro-inflammatory settings or exposure to oxidative stress strongly increases the production of the hormone from differentiating cells. These data suggest a novel function of adiponectin, directly coordinating the myogenic differentiation program and serving an autocrine function during skeletal myogenesis.
文摘A measurement campaign has been conducted at 2.35 GHz with a bandwidth of 50 MHz to ob- tain the statistics and evaluate the capacity of the backhaul link. Based on the measured channel im- pulse response, the channel gain, the eigenvalue statistics and the capacity are investigated. The distribution and corresponding parameters for describing the eigenvalue dispersion, the maximum and minimum eigenvalues are given. It is found that the backhaul link is relatively stable, which shows small variance of the channel gain. In spite of the fact that there are not many scatterers in the backhaul link, the channel rank can be enhanced by using dual-polarized antennas. Thus, the backhaul link can provide enough capacity.
文摘AIM： To investigate a potential role of S100A4 in esoph- agus squamous cell carcinoma metastasis （ESCCs）.METHODS： Expression of $100A4 and E-cadherin were analyzed in frozen sections from ESCCs （metastasis, n = 28; non-metastasis, n = 20） by reverse transcrip- tion-polymerase chain reaction, quantitative polymerase chain reaction and immunohistochemistry. To explore the influence of $100A4 on esophageal cancer invasion and metastasis, $100A4 was overexpressed or silenced by $100A4 siRNA in TE-13 or Eca-109 cells/n vitro and /n vivo.
文摘AIM: To investigate whether the side population (SP) cells possess cancer stem cell-like characteristics in vitro and the role of SP cells in tumorigenic process in gastric cancer. METHODS: We analyzed the presence of SP cells indifferent human gastric carcinoma cell lines, and then isolated and identified the SP cells from the KATO Ⅲ human gastric cancer cell line by flow cytometry. The clonogenic ability and self-renewal were evaluated by clone and sphere formation assays. The related genes were determined by reverse transcription polymerase chain reaction. To compare tumorigenic ability, SP and non-side population (NSP) cells from the KATO Ⅲ human gastric cancer cell line were subcutaneously injected into nude mice. RESULTS: SP cells from the total population accounted for 0.57% in KATO Ⅲ, 1.04% in Hs-746T, and 0.02% in AGS (CRL-1739). SP cells could grow clonally and have self-renewal capability in conditioned media. The expression of ABCG2, MDRI, Bmi-1 and Oct-4 was different between SP and NSP cells. However, there was no apparent difference between SP and NSP cells when they were injected into nude mice. CONCLUSION: SP cells have some cancer stem celllike characteristics in vitro and can be used for studying the tumorigenic process in gastric cancer.
基金This work was supported by National Natural Science Foundation of China(30670115).
文摘Each secretion （See） machinery minimally consists of three integral inner membrane pro- teins SecYEG. In order to know the distribution pattern of the Sec complex in Streptococcus mutans, we explored the subcellular localization of SecY. The anti-secY antibody was examined on Western blots to evaluate specificity. An indirect post-embedding immunogold method was used to determine the subcellular localization of the SecY in the cytoplasmic membrane of the Streptococcus mutans GS-5. lmmunoblotting experiments showed that the anti-seeY antibody specifically recognized a single band of about 47.8 kDa. Immunogold electron microscopy image of section with anti-secY antibody revealed a single intense focus of gold particles at a discrete location on the cytoplasmic membrane of the Streptococcus mutans GS-5. SecY clustered to an asymmetric microdomain, which indicated for the first time that See complex presented a unisite on the cytoplasmic membrane of Streptococcus mutans.
文摘From the five-force model application in enterprises, this paper analyzes the five-force model in the development of cruise industry in shanghai which is based on the background of supply-side structural reform. As a result, getting the answer of the cruise industry of corresponding relationship with the access capability of potential competitors, the bargaining capability of suppliers and buyers, the replacing capability of substitutes, industry competitors existing competition ability. From these relations, it summarizes the cruise industry core competitive advantages, such as high quality service, high differentiation of user experience and so on. At last, through the corresponding analyze of the strategy, providing useful advice for the sustainable development of cruise industry.
文摘To provide a risk-sharing mechanism that encourages a component supplier and a manufacturer to expand their production capacity of components and products, many researches on SCM suggested that it is better for the SC players to connect a long-term contract with flexible preconditions before doing the decision-making of production capacity. With considering of the uncertainty of demand and integrity problems between SC players, it is difficult to set reasonable preconditions. As a result, under-investment problems still occur frequently. In this paper, after we had discussed the decision-making of production capacity with the preconditions by analyzing the character of the players, we verified the under-investment problem of the supply chain. In order to clarify the optimum preconditions to alleviate the under-investment problem, we also analyzed the relations between preconditions and supply capacity of the whole supply chain. In the last part of this paper, we proposed a method of preconditions setting in such uncertain situations.
文摘This study aims to investigate and explore the relationship between vertical integration and the firm＇s innovativeness in food supply chain. For doing so, a two-stage least-squares model was used. It encompassed instrumental variables that attempt to describe the effective determinants of firm＇s vertical integration willingness. Results based on data concerning a set of 130 food-manufacturing firms, highlighted that vertical integration of a firm is strongly affected by internal incentives such as innovation rate and firm size. Moreover, it is simultaneously influenced by the economies of scale and some structure incentives. To conclude, results indicate globally that important and statistically significant differences exist across the studied firms and the small effective ones which acquire a high level of vertical integration.
基金Supported by National System of Modern Agriculture Industrial Technology(CARS-01-37)Rice Innovation Team of Liaoning Province of National System of Modern Agriculture Industrial Technology([2013]271)Key Agriculture and Achievements Specialization Planning Program of Liaoning Province(2014020004-101-3)
文摘The research performed analysis on differences of physiological property and yield of Tiejing No. 11 by different nitrogen fertilization patterns. The results indicated that while the nitrogen of basal: tillering: panicle was 6 ∶3∶1, the higher amount of nitrogen improved the chlorophyll content, photosynthetic capacity, effective panicle, grain weight and yield; the medium nitrogen level had advantage under the ratio 4:3:3; nitrogen application at lategrowth stage was suitable for low or medium nitrogen level,which could increase photosynthetic capacity and optimize the yield components and increase yield; under the same ratio for basic tiller and ear fertilizer, the increase of nitrogen could improve total nitrogen uptake and protein content, decrease nitrogen physiological efficiency and milled rice and tasting, but nitrogen recovery and harvest index changes had difference; as application at late growth stage in same nitrogen rate, total nitrogen uptake and protein content increased, nitrogen physiological efficiency and milled rice and amylose content and tasting decreased, nitrogen recovery and harvest index increased under low or medium nitrogen level and decreased under high nitrogen level. Nitrogen application 210 kg/hm^2 and the ratio 4 ∶3 ∶3 of basal:tillering: panicle made the yield increase by 2.8%-11.3%, and this is the optimal mode of nitrogen fertilizer application.
