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血清HA、PCⅢ、Ⅳ-C和LN水平对诊断肝纤维化的临床意义
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作者 薛志宏 惠玉芬 +1 位作者 李静 师延东 《延安大学学报(医学科学版)》 2004年第4期35-36,共2页
为探讨血清 HA、PCⅢ、Ⅳ-C、和 LN 水平对诊断肝纤维化的临床价值,对180例慢性肝病患者分别采用 RIA 测定血清HA、PCⅢ、Ⅳ-C 和 LN 水平。结果表明,血清 HA、PCⅢ、Ⅳ-C、和 LN 水平在慢性肝炎中度、重度及肝硬化患者明显高于对照组(P... 为探讨血清 HA、PCⅢ、Ⅳ-C、和 LN 水平对诊断肝纤维化的临床价值,对180例慢性肝病患者分别采用 RIA 测定血清HA、PCⅢ、Ⅳ-C 和 LN 水平。结果表明,血清 HA、PCⅢ、Ⅳ-C、和 LN 水平在慢性肝炎中度、重度及肝硬化患者明显高于对照组(P<0.05),且随着肝脏炎症和纤维化程度的加重而升高。结论是血清 HA、PCⅢ、Ⅳ-C 和 LN 水平可反映肝纤维化程度,四项联合检测是判断肝纤维化和早期肝硬化的无创伤性的、相对灵敏的指标。 展开更多
关键词 慢性肝病 肝纤维化 透明质酸 ⅳ-型胶原 层粘连蛋白
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Pilot Study of Molecular Mechanism on Vasculogenic Mimicry in Bi-directional Differentiated Malignant Tumors 被引量:2
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作者 孙保存 张诗武 +2 位作者 赵秀兰 张丹芳 郝希山 《The Chinese-German Journal of Clinical Oncology》 CAS 2005年第1期50-52,68,共4页
Objective: To investigate the role of collagen IV and PAS positive substancesecreted by tumor cells in vasculogenic mimicry (VM) and the effects of VM on tumor cells expressingVEGF. Methods: 158 cases of bi-direction ... Objective: To investigate the role of collagen IV and PAS positive substancesecreted by tumor cells in vasculogenic mimicry (VM) and the effects of VM on tumor cells expressingVEGF. Methods: 158 cases of bi-direction differential malignant tumor specimens withparaffin-embedded were enrolled into our study and made tissue microarray which were dual-stainedwith CD31-PAS and stained with collagen IV. The difference of the areas and distribution withpattern surrounded by between CD31 and PAS positive respectively were identified via grid-counting,as well as the difference of VEGF expression with VE absent and present. Results: The basementmembrane of VM was both PAS and collagen IV positive. VEGF expression in the bi-directiondifferential malignant tumor was higher VM-absent than VM-present and the difference wasstatistically significance in malignant melanoma and alveolar rhabdomyosarcoma (P 【 0.05).Conclusion: PAS positive substance and collagen IV compose the wall of VE and VE could provide theoxygen and nutrition for tumor growth and progression. 展开更多
关键词 bi-direction differential malignant tumor vasculogenic mimicry dual-staining tissue microarray
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恩替卡韦联合复方甘草酸苷治疗乙型肝炎肝硬化对患者肝功能及血清HA、Ⅳ-C、PC-Ⅲ水平的影响 被引量:18
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作者 何慧霞 刘丽 王蕾 《中国实用医刊》 2020年第1期90-93,共4页
目的 探讨恩替卡韦联合复方甘草酸苷治疗乙型肝炎肝硬化对患者肝功能及血清透明质酸(HA)、Ⅳ型胶原(Ⅳ-C)、Ⅲ型前胶原(PC-Ⅲ)水平的影响.方法 选取2017年1月至2018年12月郑州市第三人民医院收治的86例乙型肝炎肝硬化患者为研究对象,采... 目的 探讨恩替卡韦联合复方甘草酸苷治疗乙型肝炎肝硬化对患者肝功能及血清透明质酸(HA)、Ⅳ型胶原(Ⅳ-C)、Ⅲ型前胶原(PC-Ⅲ)水平的影响.方法 选取2017年1月至2018年12月郑州市第三人民医院收治的86例乙型肝炎肝硬化患者为研究对象,采用随机数字表法分为观察组和对照组,每组43例.对照组给予恩替卡韦治疗,观察组在此基础上加用复方甘草酸苷进行治疗.比较两组疗效,分析两组患者肝功能、血清纤维化指标及免疫功能指标的变化情况,记录两组不良反应发生情况.结果 观察组治疗有效率为95.35%(41/43),高于对照组的79.07%(34/43),P<0.05.治疗后,两组白蛋白(ALB)水平均升高,天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、总胆红素(TBiL)水平均降低,且观察组治疗后ALB水平高于对照组,AST、ALT、TBiL水平低于对照组(P<0.05).治疗后,两组层粘连蛋白(LN)、HA、PC-Ⅲ、Ⅳ-C水平均降低,且观察组治疗后LN、HA、PC-Ⅲ、IV-C水平均低于对照组(P均<0.05).治疗后,两组CD4+、CD4+/CD8+均升高,CD8+均降低,且观察组治疗后CD4+、CD4+/CD8+均高于对照组,CD8+低于对照组(P<0.05).两组均未出现明显不良反应.结论 恩替卡韦联合复方甘草酸苷治疗乙型肝炎肝硬化患者疗效确切,可显著改善患者肝功能及免疫功能状态,缓解肝纤维化,安全有效. 展开更多
关键词 恩替卡韦 复方甘草酸苷 肝炎肝硬化 肝功能 透明质酸 ⅳ-型胶原
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Effects of Electroacupuncture on Serum Indexes of Rats with Hepatic Fibrosis
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作者 闵友江 马晓芃 +5 位作者 赵天平 吴焕淦 安彩萍 杨玲 杨珊 崔学军 《Journal of Acupuncture and Tuina Science》 2008年第3期145-149,共5页
Objective: To observe the effects of electroacupuncture on the histopathological changes and serum indexes of rats' liver, and to investigate the mechanism of electroacupuncture in treating hepatic fibrosis of rats.... Objective: To observe the effects of electroacupuncture on the histopathological changes and serum indexes of rats' liver, and to investigate the mechanism of electroacupuncture in treating hepatic fibrosis of rats. Methods: The rat model of hepatic fibrosis was induced with carbon tetrachloride. Then, the rats were divided into electroacupuncture group, medicine group, and model group. The collagen of liver, and serum hyaluronic acid (HA), laminin (LN), procollagen Ⅲ (PⅢNP), and collagen Ⅳ (C-Ⅳ) were detected with morphologic methods and radioimmunoassay. Results: Compared with normal rats, the collagen was hyperplasia in the liver tissue, and the contents of the serum HA, LN, and PⅢ NP were higher in the model group. The collagen area of liver tissue, and the contents of the serum HA, and LN were lower in rats treated with electroacupuncture than model rats. The contents of serum of PⅢ NP, and C-Ⅳ changed little. Conclusion: Electroacupuncture had some effects of prevention and treatment, and the mechanism may relate to the effects of electroacupuncture in protecting liver cells, inhibiting synthesis of extracellular matrix, and promoting the breakup of collagen. 展开更多
关键词 ELECTROACUPUNCTURE Hpatic Fbrosis Hyaluronic Acid LAMININ Precollagen Collagen RATS
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