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聚乳酸类生物可降解塑料概述 被引量:31
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作者 李洪权 全大萍 +1 位作者 廖凯荣 卢泽俭 《化工新型材料》 CAS CSCD 1999年第8期3-6,共4页
介绍了现有聚乳酸类生物降解塑料的发展现状。
关键词 丙互 聚乳酸 降解塑料 生物降解
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Sequencing of hepatitis C virus cDNA with polymerase chain reaction directed sequencing *
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作者 魏来 王宇 +1 位作者 陈红松 陶其敏 《World Journal of Gastroenterology》 SCIE CAS CSCD 1997年第1期18+15-17,15-17,共4页
AIM To explore a rapid and easy sequencing method for hepatitis C virus (HCV) genome, and establish a new sequencing method in China. METHODS Polymerase Chain Reaction (PCR) was combined with DNA sequencing techn... AIM To explore a rapid and easy sequencing method for hepatitis C virus (HCV) genome, and establish a new sequencing method in China. METHODS Polymerase Chain Reaction (PCR) was combined with DNA sequencing technique. PCR products were purified by agarose gel electrophoresis, polyacrylamide gel electrophoresis (PAGE), Polyethylene glycol (PEG) respectively. Then in the presence of a 5′ labeling PCR primer, purified PCR products were directly sequenced. By this method, HCV NS5b cDNA from two HCV infected individuals (HC 42 and HC 49) were sequenced. 展开更多
关键词 Hepatitis C virus DNA viral DNA complementary Polymerase chain reaction Sequence analysis DNA Mutation
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Optimizing hepatitis C virus treatment through pharmacist interventions: Identification and management of drug-drug interactions 被引量:5
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作者 Jacob A Langness Matthew Nguyen +2 位作者 Amanda Wieland Gregory T Everson Jennifer J Kiser 《World Journal of Gastroenterology》 SCIE CAS 2017年第9期1618-1626,共9页
To quantify drug-drug-interactions (DDIs) encountered in patients prescribed hepatitis C virus (HCV) treatment, the interventions made, and the time spent in this process.METHODSAs standard of care, a clinical pharmac... To quantify drug-drug-interactions (DDIs) encountered in patients prescribed hepatitis C virus (HCV) treatment, the interventions made, and the time spent in this process.METHODSAs standard of care, a clinical pharmacist screened for DDIs in patients prescribed direct acting antiviral (DAA) HCV treatment between November 2013 and July 2015 at the University of Colorado Hepatology Clinic. HCV regimens prescribed included ledipasvir/sofosbuvir (LDV/SOF), paritaprevir/ritonavir/ombitasvir/dasabuvir (OBV/PTV/r + DSV), simeprevir/sofosbuvir (SIM/SOF), and sofosbuvir/ribavirin (SOF/RBV). This retrospective analysis reviewed the work completed by the clinical pharmacist in order to measure the aims identified for the study. The number and type of DDIs identified were summarized with descriptive statistics.RESULTSSix hundred and sixty four patients (83.4% Caucasian, 57% male, average 56.7 years old) were identified; 369 for LDV/SOF, 48 for OBV/PTV/r + DSV, 114 for SIM/SOF, and 133 for SOF/RBV. Fifty-one point five per cent of patients were cirrhotic. Overall, 5217 medications were reviewed (7.86 medications per patient) and 781 interactions identified (1.18 interactions per patient). The number of interactions were fewest for SOF/RBV (0.17 interactions per patient) and highest for OBV/PTV/r + DSV (2.48 interactions per patient). LDV/SOF and SIM/SOF had similar number of interactions (1.28 and 1.48 interactions per patient, respectively). Gastric acid modifiers and vitamin/herbal supplements commonly caused interactions with LDV/SOF. Hypertensive agents, analgesics, and psychiatric medications frequently caused interactions with OBV/PTV/r + DSV and SIM/SOF. To manage these interactions, the pharmacists most often recommended discontinuing the medication (28.9%), increasing monitoring for toxicities (24.1%), or separating administration times (18.2%). The pharmacist chart review for each patient usually took approximately 30 min, with additional time for more complex patients.CONCLUSIONDDIs are common with HCV medications and management can require medication adjustments and increased monitoring. An interdisciplinary team including a clinical pharmacist can optimize patient care. 展开更多
关键词 Clinical pharmacist Drug-drug interaction Hepatitis C virus treatment
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Interpenetrating polymers supported on microporous polypropylene membranes for the transport of chromium ions 被引量:2
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作者 Yesid Tapiero Julio Sánchez BernabéL.Rivas 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2017年第7期938-946,共9页
Modifying polypropylene membranes with interpenetrating polymer networks(IPNs) through the incorporation of poly(glycidyl methacrylate-N-methyl-D-glucamine)(P(GMA-NMG)) was performed by in situ synthesis via radical p... Modifying polypropylene membranes with interpenetrating polymer networks(IPNs) through the incorporation of poly(glycidyl methacrylate-N-methyl-D-glucamine)(P(GMA-NMG)) was performed by in situ synthesis via radical polymerization. The surface of the polypropylene membrane was activated by hydrophilic grafted polyelectrolyte, and then, pressure injection was used for the impregnation of the reactive solution in the membrane.Two types of pore-filled membranes were synthesized, chelating interpenetrating homopolymer networks of P(GMA-NMG), and chelating-ion exchange interpenetrating polymer networks(e.g., P(GMA-NMG)/P(AA),P(GMA-NMG)/P(AMPSA), and P(GMA-NMG)/P(Cl VBTA)). After their synthesis, the modified polypropylene membranes were characterized using techniques such as the electrokinetic potential, SEM, FT-IR, and Donnan dialysis to corroborate the chromium ion transport. The P(GMA-NMG) and complex network membranes exhibited a hydrophilic character with a water-uptake capacity between 20% and 35% and a percentage of modification between 4.0% and 7.0% in comparison with the behavior of the unmodified polypropylene membrane.Hexavalent chromium ions were efficiently transported from the food chamber at p H 9.0 when the 65.2%MTA1 P(Cl VBTA) homopolymer IPN membrane and 48.5% MTAG P(GMA-NMG)/P(Cl VBTA) IPN membrane were used. Similarly, hexavalent chromium ions were removed from the food chamber at pH 3.0 when MTAG(63.30%) and MTA1(35.68%) were used in 1 mol·L^(-1)Na Cl solution as the extraction reagent. 展开更多
关键词 POLYPROPYLENE N-methyI-D-glucamine Ion exchange Donnan dialysis Interpenetrating polymer networks CHROMIUM
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Interactions of 1-hexyl-3-methylimidazolium Bromide with Acetone 被引量:1
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作者 Cui-ping Zhai Jian-ji Wang +2 位作者 Xiao-peng Xuan Han-qing Wang Miao Chen 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 北大核心 2006年第5期447-450,共4页
^1H and ^13C NMR chemical shifts were determined to investigate the interactions of acetone with a room temperature ionic liquid 1-hexyl-3- methylimidazolium bromide [C6mim]Br at various mole fractions. Changes in che... ^1H and ^13C NMR chemical shifts were determined to investigate the interactions of acetone with a room temperature ionic liquid 1-hexyl-3- methylimidazolium bromide [C6mim]Br at various mole fractions. Changes in chemical shifts of hydrogen nuclei and of carbon nuclei with the acetone concentration indicated the formation of hydrogen bond between anion of the ionic liquid and methyl protons of acetone. The NMR results were in good agreement with the ab initio computational results. 展开更多
关键词 ^1H and ^13C NMIR Chemical shift 1-hexyl-3-methylimidazolium bromide ionic liquid ACETONE Interaction
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Salt Effect on the Liquid-Liquid Equilibrium of (Water + Propionic Acid + Cyclohexanol) System at T=(298.2,303.2,and 308.2) K 被引量:1
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作者 Bahram Ghalami-Choobar Ali Ghanadzadeh and Shahram Kousarimehr 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2011年第4期565-569,共5页
Effects of salt and temperature on the liquid phase equilibrium of the(water + propionic acid + cyclohexanol) system were investigated.The liquid-liquid equilibrium data in the presence of KCl for various salt ionic s... Effects of salt and temperature on the liquid phase equilibrium of the(water + propionic acid + cyclohexanol) system were investigated.The liquid-liquid equilibrium data in the presence of KCl for various salt ionic strength of 0.5,1.0,1.5,2.0,and 2.5 mol·dm3 and in absence of the salt at T=(298.2,303.2,and 308.2)K were determined.The experimental results were correlated based on the Othmer-Tobias equation and Pitzer ion-interaction model.Thermodynamic properties such as distribution coefficients and activity coefficients of propionic acid in water + cyclohexanol were determined.In addition,the separation factor,S,of the chosen solvent was obtained for the investigated system. 展开更多
关键词 liquid-liquid equilibrium salt effect propionic acid distribution coefficient
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Screening of genes of proteins interacting with p7 protein of hepatitis C virus from human liver cDNA library by yeast two-hybrid system 被引量:2
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作者 Yan-Ping Huang Shu-Lin Zhang +11 位作者 Jun Cheng Lin Wang Jiang Guo Yan Liu Yuan Yang Li-Ying Zhang Gui-Qin Bai Xue Song Gao Dong Ji Shu-Mei Lin Yan-Wei Zhong Qing Shao 《World Journal of Gastroenterology》 SCIE CAS CSCD 2005年第30期4709-4714,共6页
AIM: To investigate the biological function of p7 protein and to look for proteins interacting with p7 protein in hepatocytes. METHODS: We constructed p7 protein bait plasmid by cloning the gene of p7 protein into p... AIM: To investigate the biological function of p7 protein and to look for proteins interacting with p7 protein in hepatocytes. METHODS: We constructed p7 protein bait plasmid by cloning the gene of p7 protein into pGBKTT, then transformed it into yeast AH109 (a type). The transformed yeast was mated with yeast Y187 (α type) containing liver cDNA library plasmid, pACT2 in 2×YPDA medium. Diploid yeast was plated on synthetic dropout nutrient medium (SD/- Trp-Leu-His-Ade) containing x-α-gal for selection and screening. After extracting and sequencing of plasmids from blue colonies, we performed sequence analysis by bioinformatics. RESULTS: Fifty colonies were selected and sequenced. Among them, one colony was Homo sapiens signal sequence receptor, seven colonies were Homo sapiens H19, seven colonies were immunoglobulin superfamily containing leucine-rich repeat, three colonies were spermatid peri-nuclear RNA binding proteins, two colonies were membrane-spanning 4-domains, 24 colonies were cancer-associated antigens, four colonies were nudeoporin 214 ku and two colonies were CLL-associated antigens. CONCLUSION: The successful cloning of gene of protein interacting with p7 protein paves a way for the study of the physiological function of p7 protein and its assodated protein. 展开更多
关键词 Hepatitis C virus p7 protein Interacting proteins Yeast two-hybrid system
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Laser Light Scattering Study on Aggregation of Cellulose Diacetate in Acetone 被引量:1
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作者 Ding-hai Xie Xu-hua Li +1 位作者 Xi-ling Fang Chun-feng Ma 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 2014年第3期256-258,共3页
We have investigated the properties of cellulose diacetate in solution by using laser light scattering. The cellulose diacetate molecules can form micelles and micellar clusters in acetone besides the individual chain... We have investigated the properties of cellulose diacetate in solution by using laser light scattering. The cellulose diacetate molecules can form micelles and micellar clusters in acetone besides the individual chains. As the concentration increases, the average hydrodynamic radius (Rh) linearly increases, whereas the ratio of gyration radius to hydrodynamic radins 〈Rg〉/〈Rh〉 linearly decreases. It indicates that the micelles associate and form micellar clusters due to the intermolecular interactions. 展开更多
关键词 Cellulose diacetate Laser light scattering Multi-aggregation form structure
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Theoretical Investigating Mechanisms of Drug-Resistance Generated by Mutation-Induced Changes in Influenza Viruses 被引量:1
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作者 Song Luo Xiaoyu Zhao +1 位作者 Yihui Wang Lili Duan 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 2021年第6期785-796,I0003,I0061-I0067,共20页
Influenza A(A/H_(x)N_(y))is a significant public health concern due to its high infectiousness and mortality.Neuraminidase,which interacts with sialic acid(SIA)in host cells,has become an essential target since its hi... Influenza A(A/H_(x)N_(y))is a significant public health concern due to its high infectiousness and mortality.Neuraminidase,which interacts with sialic acid(SIA)in host cells,has become an essential target since its highly conserved catalytic center structure,while resistance mutations have already generated.Here,a detailed investigation of the drug resistance mechanism caused by mutations was performed for subtype N9(A/H7N9).Molecular dynamics simulation and alanine-scanning-interaction-entropy method(ASIE)were used to explore the critical differences between N9 and Zanamivir(ZMR)before and after R294K mutation.The results showed that the mutation caused the hydrogen bond between Arg294 and ZMR to break,then the hydrogen bonding network was disrupted,leading to weakened binding ability and resistance.While in wild type(A/H7N9^(WT)),this hydrogen bond was initially stable.Meanwhile,N9 derived from A/H11N9 was obtained as an R292K mutation.Then the relative binding free energy of N9 with five inhibitors(SIA,DAN,ZMR,G28,and G39)was predicted,basically consistent with experimental values,indicating that the calculated results were reliable by ASIE.In addition,Arg292 and Tyr406 were hot spots in the A/H11N9^(WT)-drugs.However,Lys292 was not observed as a favorable contributing residue in A/H11N9^(R292K),which may promote resistance.In comparison,Tyr406 remained the hotspot feature when SIA,ZMR,and G28 binding to A/H11N9^(R292K).Combining the two groups,we speculate that the resistance was mainly caused by the disruption of the hydrogen bonding network and the transformation of hotspots.This study could guide novel drug delivery of drug-resistant mutations in the treatment of A/H_(x)N9. 展开更多
关键词 N9 Drug resistance Alanine-scanning-interaction-entropy method Binding free energy
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Relationship between the pathogenesis of sarcoidosis and hepatitis C
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作者 Sevtap Sipahi Demirkok 《World Journal of Gastroenterology》 SCIE CAS CSCD 2007年第12期1883-1884,共2页
TO THE EDITORI read the article by Kim et al with great interest. This is a rare case of systemic sarcoidosis in a patient with chronic hepatitis C without treatment for neither sarcoidosis nor hepatitis C. In this ca... TO THE EDITORI read the article by Kim et al with great interest. This is a rare case of systemic sarcoidosis in a patient with chronic hepatitis C without treatment for neither sarcoidosis nor hepatitis C. In this case, spontaneous resolution of sarcoidosis was noted while hepatitis activities were aggravating. The authors suggest that this relationship mentioned above was not a fortuitous coincidence and these two diseases share a common pathogenesis due to the fact that interferon-induced immune activation is an important mechanism of viral replication suppression in chronic hepatitis C, hepatitis activities may be suppressed when chronic hepatitis C is combined with active sarcoidosis. 展开更多
关键词 SARCOIDOSIS Hepatitis C Tmmunopathogenesis
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Ultrasonic study on molecular interactions in binary mixtures of formamide with 1-propanol or 2-propanol
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作者 Manju Rani Suman Gahlyan +1 位作者 Ankur Gaur Sanjeev Maken 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2015年第4期689-698,共10页
Ultrasonic speeds have been measured at 298.15 K and 308.15 K for mixtures of formamide + 1 -propanol or 2-propanol. For an equimolar mixture, excess molar compressibility follows the sequence of l-propanol 〉 2-prop... Ultrasonic speeds have been measured at 298.15 K and 308.15 K for mixtures of formamide + 1 -propanol or 2-propanol. For an equimolar mixture, excess molar compressibility follows the sequence of l-propanol 〉 2-propanol. The ultrasonic speed data are correlated by various correlations such as Nomoto's relation, van Dael's mixing relation and impedance dependence relation, and analyzed in terms of Jacobson's free length theory and Schaaffs collision factor theory. Excess isentropic compressibility is calculated from ex- perimental ultrasonic speed data and previously reported excess volume data. The excess molar ultrasonic speed and isentropic compressibility values are fitted to Redlich-Kister polynomial equation. Other proper- ties such as molecular association, available volume, free volume, and intermolecular free length are also calculated. The excess isentropic compressibility data are also interpreted in terms of graph theoretical ap- proach. The calculated isentropic compressibility values are well consistent with the experimental data. It is found that the interaction between formamide and propanol increases when hydroxyl group attached to a carbon atom has more -CH3 groups. 展开更多
关键词 Ultrasonic speedGraph theoretical approachFormamidePropanollntermolecular interaction
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Interplay among cellular polarization,lipoprotein metabolism and hepatitis C virus entry
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作者 Ignacio Benedicto Francisca Molina-Jiménez +2 位作者 Ricardo Moreno-Otero Manuel López-Cabrera Pedro L Majano 《World Journal of Gastroenterology》 SCIE CAS CSCD 2011年第22期2683-2690,共8页
Hepatitis C virus (HCV) infects more than three million new individuals worldwide each year. In a high percent age of patients, acute infections become chronic, eventually progressing to fibrosis, cirrhosis, and hepat... Hepatitis C virus (HCV) infects more than three million new individuals worldwide each year. In a high percent age of patients, acute infections become chronic, eventually progressing to fibrosis, cirrhosis, and hepatocellular carcinoma. Given the lack of effective prophylactic or therapeutic vaccines, and the limited sustained virological response rates to current therapies, new approaches are needed to prevent, control, and clear HCV infection.Entry into the host cell, being the first step of the viral cycle, is a potential target for the design of new antiviral compounds. Despite the recent discovery of the tight junction-associated proteins claudin-1 and occludin as HCV co-receptors, which is an important step towards the understanding of HCV entry, the precise mechanisms are still largely unknown. In addition, increasing evidence indicates that tools that are broadly employed to study HCV infection do not accurately reflect the real process in terms of viral particle composition and host cell phenotype. Thus, systems that more closely mimic natural infection are urgently required to elucidate the mechanisms of HCV entry, which will in turn help to design antiviral strategies against this part of the infection process. 展开更多
关键词 Cellular polarization Tight junctions Lipoprotein metabolism Hepatitis C virus
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Molecular Dynamics Study of Interaction between Acrylamide Copolymers and Alumina Crystal 被引量:3
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作者 Feng-he Wang Feng-yun Wang Xue-dong Gong 《Chinese Journal of Chemical Physics》 SCIE CAS CSCD 2012年第5期571-576,I0003,I0004,共8页
Four acrylamide polymer flocculants, anionic polyacrylamide P(AA-co-AM), cationic poly- acrylamide P(DMB-co-AM), nonionic polyacrylamide P(AM), and hydrophobical polyacry- lamide P(OA-co-AM) have been prepared... Four acrylamide polymer flocculants, anionic polyacrylamide P(AA-co-AM), cationic poly- acrylamide P(DMB-co-AM), nonionic polyacrylamide P(AM), and hydrophobical polyacry- lamide P(OA-co-AM) have been prepared by copolymerizing with acrylic acid, cationic monomer dimethylethyl (acryloxyethyl) ammonium bromide (DMB) and hydrophobical monomer octadecyl acrylate with acrylamide. The interactions between the flocculants with the (012) surface of alumina crystal (A1203) have been simulated by molecular dynamics method. All the polymers can bind tightly with A1203 crystal, the interaction between the O of polymers and A1 of the (012) surface of A1203 is significantly strong. The order of binding energy is as follows: P(DMB-co-AM)〉P(OA-co-AM)〉P(AA-co-AM)〉P(AM), implying a better flocculation performance of P(DMB-co-AM) than the others. Analy- sis indicates that binding energy is mainly determined by Coulomb interaction. Bonds are found between the O atoms of the polymers and the A1 atoms of A1203. The poly- mers' structures deform when they combine with A1203 crystal, but the deformation en- ergies are low and far less than non-bonding energies. Flocculation experiments in sus- pension medium of l%Kaolin show a transmittancy of 90.8% for 6 mg/L P(DMB-co-AM) and 73.0% for P(AM). The sequence of flocculation performance of four polymers is P(DMB-co-AM)〉P(OA-co-AM)〉P(AA-co-AM)〉P(AM), which is in excellent agreement with the simulation results of binding energy. 展开更多
关键词 Molecular dynamics simulation Acrylamide copolymer Binding energy Floc-culation
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Study on the interaction between palladium(II)-chlorpromazine hydrochloride and sodium tungstate by the resonance Rayleigh scattering, second-order scattering and frequency doubling scattering spectra and its analytical application 被引量:1
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作者 CHEN PeiLi LIU ShaoPu +2 位作者 LIU ZhongFang HU XiaoLi LI CuiXia 《Science China Chemistry》 SCIE EI CAS 2011年第3期506-514,共9页
The interaction between palladium(II)-chlorpromazine hydrochloride and sodium tungstate was investigated by ultravioletvisible absorption,resonance Rayleigh scattering(RRS),second-order scattering(SOS)and frequency do... The interaction between palladium(II)-chlorpromazine hydrochloride and sodium tungstate was investigated by ultravioletvisible absorption,resonance Rayleigh scattering(RRS),second-order scattering(SOS)and frequency doubling scattering (FDS)spectroscopy.In pH 5.3 Britton-Robinson(BR)buffer medium,chlorpromazine hydrochloride(CPZ)reacted with Pd(II) to form 2:1 cationic chelate,which further reacted with Na2WO4 to form a 1:1 ternary ion-association complex ([Pd(CPZ)2]·WO4).As a result,the signal intensities of RRS,SOS and FDS were enhanced greatly,and the enhancements of scattering were proportional to the CPZ concentration in a certain range.Their maximum wavelengths were located at 310 nm, 570 nm and 391 nm,respectively and the detection limits(3)were 1.6 ng/mL(RRS method),3.2 ng/mL(SOS method)and 5.6 ng/mL(FDS method).The optimum reaction conditions,the influences of coexisting substances and analytical application were mainly investigated by RRS method due to its highest sensitivity.A highly sensitive,simple,rapid and new method had been proposed to determine CPZ in the pharmaceutical form and residue of CPZ in pork.In addition,the Gibbs free energy change(△Gf)of ion-association reaction was computed by using B3LYP/3-21g*/LanL2dz method.The formation of ion-association and the reasons for the enhancement of RRS were also discussed. 展开更多
关键词 resonance Rayleigh scattering second-order scattering frequency doubling scattering chlorpromazine hydrochloride palladium(II) Na2WO4
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Electrochemically sensitive supra-crosslink and its corresponding hydrogel 被引量:5
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作者 DU Ping CHEN GuoSong JIANG Ming 《Science China Chemistry》 SCIE EI CAS 2012年第5期836-843,共8页
In this work, through inclusion complexation between cyclodextrin (CD) host and ferrocene (Fc) guest, a monomer with double bond was incorporated to the surface of CdS quantum dot (QD). The obtained supra-structure co... In this work, through inclusion complexation between cyclodextrin (CD) host and ferrocene (Fc) guest, a monomer with double bond was incorporated to the surface of CdS quantum dot (QD). The obtained supra-structure could act as a supra-crosslink (Fc-SCL) in its copolymerizing with N,N-dimethylacrylamide (DMA) leading to a hybrid supramolecular hydrogel (Fc-Gel). Fc-SCL inherited satisfactory electrochemical activity from Fc. When the weight percentage of Fc-SCL in Fc-Gel was increased, an apparent increase of elastic modulus (G ′) was observed. Furthermore, Fc-Gel also exhibited good fluorescent properties. It was also demonstrated that the inclusion complexation of CD and Fc played a crucial role in constructing the hydrogel; therefore, this Fc-Gel was an organic-inorganic hybrid hydrogel induced by supramolecular interaction. 展开更多
关键词 supramolecular hydrogel electrochemical activity supra-crosslink inclusion complexation CYCLODEXTRIN
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An Investigation of ~4He+^(12)C and ~4He+^(16)O Reactions Using the Cluster Model
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作者 A.H.Al-Ghamdi Awad A.Ibraheem M.El-Azab Farid 《Communications in Theoretical Physics》 SCIE CAS CSCD 2012年第7期135-140,共6页
The α-target semimicroscopic single folding potentials have been derived by folding a composite (repul-sive and attractive) effective α-α interaction with the α-cluster distribution density in the target nuclei. T... The α-target semimicroscopic single folding potentials have been derived by folding a composite (repul-sive and attractive) effective α-α interaction with the α-cluster distribution density in the target nuclei. The obtained potentials are considered as the real part of the nuclear optical model potentials, while the imaginary parts are phe-nomenologicaly expressed using the Woods-Saxon form. Nine sets of measured experimental data of the 4He+12C and 4 He+16O elastic rainbow scattering over the energy range 80-240 MeV are analyzed using the obtained potentials. The data are successfully reproduced using the extracted potentials. The resulted reaction cross sections are also investigated and compared with the available corresponding data. 展开更多
关键词 optical model elastic scattering folding potential cluster model
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Stable and low-resistance polydopamine methacrylamide-polyacrylamide hydrogel for brain-computer interface 被引量:4
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作者 Lanlan Liu Yafeng Liu +4 位作者 Ruitao Tang Jun Ai Yinji Ma Ying Chen Xue Feng 《Science China Materials》 SCIE EI CAS CSCD 2022年第8期2298-2308,共11页
Signal drift and performance instability of brain-computer interface devices induced by the interface failure between rigid metal electrodes and soft human skin hinder the precise data acquisition of electroencephalog... Signal drift and performance instability of brain-computer interface devices induced by the interface failure between rigid metal electrodes and soft human skin hinder the precise data acquisition of electroencephalogram(EEG).Thus,it is desirable to achieve a robust interface for brain-computer interface devices.Here,a kind of polydopamine methacrylamide-polyacrylamide(PDMA-PAAM)hydrogel is developed.To improve the adhesion,dopamine is introduced into the polyacrylamide hydrogel,through the amino and catechol groups of dopamine in an organic-inorganic interface to build a covalent and non-covalent interaction.A strong attachment and an effective modulus transition system can be formed between the metal electrodes and human skin,so that the peeling force between the PDMAPAAM hydrogel and the porcine skin can reach 22 N m^(-1).In addition,the stable conductivity and long-term operating life of the PDMA-PAAM hydrogel for more than 60 days at room temperature are achieved by adding sodium chloride(NaCl)and glycerol,respectively.The PDMA-PAAM hydrogel membrane fabricated in this work is integrated onto a flexible Au electrode applied in a brain-computer interface.In comparison,the collected EEG signal intensity and waveform are consistent with that of the commercial counterparts.And obviously,the flexible electrode with PDMA-PAAM hydrogel membrane is demonstrated to enable a more stable and userfriendly interface. 展开更多
关键词 flexible electronics DOPAMINE HYDROGELS braincomputer interface ELECTROENCEPHALOGRAM
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